locus-tag	class	description
KBQ49_RS00090	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
KBQ49_RS00130	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KBQ49_RS00135	COG1404	Belongs to the peptidase S8 family
KBQ49_RS00170	COG1295	ribonuclease BN
KBQ49_RS00175	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KBQ49_RS00200	COG0521	Mo-molybdopterin cofactor biosynthetic process
KBQ49_RS00270	COG3537	Alpha-1,2-mannosidase
KBQ49_RS00295	COG1472	Belongs to the glycosyl hydrolase 3 family
KBQ49_RS00305	COG3525	Glycosyl hydrolase, family 20, catalytic domain
KBQ49_RS00310	COG1388	LysM domain
KBQ49_RS00310	COG3858	chitin binding
KBQ49_RS00325	COG0837	glucose binding
KBQ49_RS00335	COG1385	rRNA (uridine-N3-)-methyltransferase activity
KBQ49_RS00345	COG0494	nUDIX hydrolase
KBQ49_RS00350	COG1218	3'(2'),5'-bisphosphate nucleotidase
KBQ49_RS00355	COG3956	TIGRFAM MazG family protein
KBQ49_RS00360	COG1742	UPF0060 membrane protein
KBQ49_RS00365	COG0330	HflC and HflK could
KBQ49_RS00400	COG0697	spore germination
KBQ49_RS00425	COG2124	cytochrome p450
KBQ49_RS00430	COG2124	cytochrome p450
KBQ49_RS00435	COG1141	Ferredoxin
KBQ49_RS00440	COG1028	Short-chain dehydrogenase reductase Sdr
KBQ49_RS00445	COG2124	cytochrome p450
KBQ49_RS00450	COG0142	geranyltranstransferase activity
KBQ49_RS00455	COG1657	PFAM Prenyltransferase squalene oxidase
KBQ49_RS00465	COG1304	FMN binding
KBQ49_RS00470	COG1960	acyl-CoA dehydrogenase activity
KBQ49_RS00485	COG4206	TonB-dependent receptor
KBQ49_RS00495	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
KBQ49_RS00500	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KBQ49_RS00505	COG0463	Glycosyl transferase, family 2
KBQ49_RS00510	COG0517	IMP dehydrogenase activity
KBQ49_RS00515	COG2982	Protein involved in outer membrane biogenesis
KBQ49_RS00520	COG1272	protein, Hemolysin III
KBQ49_RS00525	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
KBQ49_RS00535	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
KBQ49_RS00540	COG0626	cystathionine gamma-synthase activity
KBQ49_RS00545	COG0460	homoserine dehydrogenase
KBQ49_RS00545	COG0527	aspartate kinase activity
KBQ49_RS00550	COG2267	carboxylic ester hydrolase activity
KBQ49_RS00560	COG1760	l-serine dehydratase
KBQ49_RS00575	COG3038	cytochrome b561
KBQ49_RS00595	COG2814	Major facilitator Superfamily
KBQ49_RS00600	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
KBQ49_RS00610	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KBQ49_RS00615	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KBQ49_RS00630	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
KBQ49_RS00690	COG0519	Catalyzes the synthesis of GMP from XMP
KBQ49_RS00705	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
KBQ49_RS00725	COG0840	transmembrane signaling receptor activity
KBQ49_RS00735	COG1113	amino acid transport
KBQ49_RS00755	COG2239	Acts as a magnesium transporter
KBQ49_RS00760	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
KBQ49_RS00765	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
KBQ49_RS00775	COG1660	Displays ATPase and GTPase activities
KBQ49_RS00785	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KBQ49_RS00800	COG1137	ATPase activity
KBQ49_RS00815	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
KBQ49_RS00860	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
KBQ49_RS00885	COG0628	permease
KBQ49_RS00895	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
KBQ49_RS00900	COG3178	'Phosphotransferase
KBQ49_RS00915	COG1555	photosystem II stabilization
KBQ49_RS00935	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
KBQ49_RS00940	COG1477	protein flavinylation
KBQ49_RS00965	COG4774	siderophore transport
KBQ49_RS00970	COG2146	nitrite reductase [NAD(P)H] activity
KBQ49_RS00980	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
KBQ49_RS00985	COG0719	Fe-S assembly protein
KBQ49_RS00990	COG0396	ATPase activity
KBQ49_RS00995	COG0719	Fe-S assembly protein
KBQ49_RS01010	COG0693	protein deglycase activity
KBQ49_RS01025	COG0739	heme binding
KBQ49_RS01040	COG1764	response to oxidative stress
KBQ49_RS01050	COG0384	phenazine biosynthesis protein PhzF
KBQ49_RS01055	COG0527	aspartate kinase activity
KBQ49_RS01080	COG0142	geranyltranstransferase activity
KBQ49_RS01085	COG0629	single-stranded DNA binding
KBQ49_RS01090	COG3550	peptidyl-serine autophosphorylation
KBQ49_RS01105	COG3104	oligopeptide transport
KBQ49_RS01110	COG1297	OPT oligopeptide transporter protein
KBQ49_RS01115	COG0823	Involved in the tonB-independent uptake of proteins
KBQ49_RS01115	COG1506	peptidase
KBQ49_RS01135	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KBQ49_RS01140	COG2879	small protein
KBQ49_RS01145	COG1966	Carbon starvation protein
KBQ49_RS01180	COG2211	Major facilitator Superfamily
KBQ49_RS01220	COG0835	chemotaxis
KBQ49_RS01225	COG0840	transmembrane signaling receptor activity
KBQ49_RS01230	COG0840	transmembrane signaling receptor activity
KBQ49_RS01235	COG0840	transmembrane signaling receptor activity
KBQ49_RS01240	COG0643	Histidine kinase
KBQ49_RS01240	COG2198	Histidine kinase
KBQ49_RS01265	COG3878	Protein conserved in bacteria
KBQ49_RS01270	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
KBQ49_RS01280	COG2205	protein histidine kinase activity
KBQ49_RS01290	COG4452	Inner membrane protein CreD
KBQ49_RS01320	COG0735	belongs to the Fur family
KBQ49_RS01355	COG1529	Aldehyde oxidase and xanthine dehydrogenase
KBQ49_RS01360	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
KBQ49_RS01365	COG2080	2 iron, 2 sulfur cluster binding
KBQ49_RS01465	COG1187	pseudouridine synthase activity
KBQ49_RS01490	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
KBQ49_RS01510	COG1132	(ABC) transporter
KBQ49_RS01530	COG0583	DNA-binding transcription factor activity
KBQ49_RS01570	COG1981	membrane
KBQ49_RS01595	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KBQ49_RS01600	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KBQ49_RS01610	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KBQ49_RS01615	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
KBQ49_RS01620	COG0750	zinc metalloprotease
KBQ49_RS01625	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
KBQ49_RS01630	COG0575	Belongs to the CDS family
KBQ49_RS01635	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
KBQ49_RS01645	COG0528	UMP kinase activity
KBQ49_RS01655	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
KBQ49_RS01695	COG0024	Methionine aminopeptidase
KBQ49_RS01710	COG1393	Belongs to the ArsC family
KBQ49_RS01715	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KBQ49_RS01725	COG0367	asparagine synthase
KBQ49_RS01760	COG1566	PFAM secretion protein HlyD family protein
KBQ49_RS01765	COG2814	Major facilitator Superfamily
KBQ49_RS01800	COG0557	exoribonuclease II activity
KBQ49_RS01810	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KBQ49_RS01820	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
KBQ49_RS01840	COG0704	Plays a role in the regulation of phosphate uptake
KBQ49_RS01850	COG0581	inorganic phosphate transmembrane transporter activity
KBQ49_RS01860	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
KBQ49_RS01865	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
KBQ49_RS01885	COG0659	secondary active sulfate transmembrane transporter activity
KBQ49_RS01890	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
KBQ49_RS01900	COG1024	Enoyl-CoA hydratase
KBQ49_RS01965	COG2205	protein histidine kinase activity
KBQ49_RS01965	COG0784	Response regulator, receiver
KBQ49_RS01965	COG5002	protein histidine kinase activity
KBQ49_RS01970	COG2733	membrane
KBQ49_RS01990	COG0686	Belongs to the AlaDH PNT family
KBQ49_RS01995	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
KBQ49_RS02000	COG1396	sequence-specific DNA binding
KBQ49_RS02000	COG1917	Cupin 2, conserved barrel domain protein
KBQ49_RS02005	COG1012	belongs to the aldehyde dehydrogenase family
KBQ49_RS02025	COG2223	nitrite transmembrane transporter activity
KBQ49_RS02035	COG0243	molybdopterin cofactor binding
KBQ49_RS02060	COG0477	Major facilitator Superfamily
KBQ49_RS02070	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KBQ49_RS02075	COG0174	glutamine synthetase
KBQ49_RS02080	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
KBQ49_RS02085	COG0174	glutamine synthetase
KBQ49_RS02095	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
KBQ49_RS02100	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
KBQ49_RS02120	COG3842	ATPase activity
KBQ49_RS02125	COG1176	ABC-type spermidine putrescine transport system, permease component I
KBQ49_RS02130	COG1177	transmembrane transport
KBQ49_RS02135	COG1012	belongs to the aldehyde dehydrogenase family
KBQ49_RS02150	COG4535	Mg2 and Co2 transporter CorC
KBQ49_RS02165	COG1702	phosphate starvation-inducible protein PhoH
KBQ49_RS02180	COG0741	lytic transglycosylase activity
KBQ49_RS02185	COG0723	plastoquinol--plastocyanin reductase activity
KBQ49_RS02190	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
KBQ49_RS02200	COG2857	Cytochrome c1
KBQ49_RS02205	COG0625	glutathione transferase activity
KBQ49_RS02210	COG2969	positive regulation of protein catabolic process
KBQ49_RS02250	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
KBQ49_RS02260	COG2095	MarC family integral membrane protein
KBQ49_RS02270	COG1611	Belongs to the LOG family
KBQ49_RS02275	COG3275	phosphorelay sensor kinase activity
KBQ49_RS02320	COG0556	nucleotide-excision repair
KBQ49_RS02430	COG2948	multi-organism process
KBQ49_RS02535	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
KBQ49_RS02545	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
KBQ49_RS02550	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
KBQ49_RS02600	COG0438	transferase activity, transferring glycosyl groups
KBQ49_RS02605	COG0438	transferase activity, transferring glycosyl groups
KBQ49_RS02615	COG0438	transferase activity, transferring glycosyl groups
KBQ49_RS02640	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
KBQ49_RS02650	COG1960	acyl-CoA dehydrogenase activity
KBQ49_RS02685	COG1570	exodeoxyribonuclease VII activity
KBQ49_RS02690	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
KBQ49_RS02695	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
KBQ49_RS02695	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
KBQ49_RS02700	COG0802	atpase or kinase
KBQ49_RS02705	COG0860	N-Acetylmuramoyl-L-alanine amidase
KBQ49_RS02710	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
KBQ49_RS02730	COG1028	Short-chain dehydrogenase reductase Sdr
KBQ49_RS02750	COG2081	HI0933 family
KBQ49_RS02755	COG4681	YaeQ
KBQ49_RS02760	COG0564	pseudouridine synthase activity
KBQ49_RS02770	COG0625	glutathione transferase activity
KBQ49_RS02775	COG0657	acetylesterase activity
KBQ49_RS02780	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
KBQ49_RS02805	COG0513	Belongs to the DEAD box helicase family
KBQ49_RS02810	COG0488	(ABC) transporter
KBQ49_RS02830	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
KBQ49_RS02840	COG1472	Belongs to the glycosyl hydrolase 3 family
KBQ49_RS02885	COG1846	Transcriptional regulator
KBQ49_RS02900	COG0386	Belongs to the glutathione peroxidase family
KBQ49_RS02980	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
KBQ49_RS02985	COG0084	hydrolase, TatD family'
KBQ49_RS03000	COG1960	acyl-CoA dehydrogenase activity
KBQ49_RS03010	COG0305	Participates in initiation and elongation during chromosome replication
KBQ49_RS03015	COG0415	Belongs to the DNA photolyase family
KBQ49_RS03030	COG0583	DNA-binding transcription factor activity
KBQ49_RS03045	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KBQ49_RS03085	COG1404	Belongs to the peptidase S8 family
KBQ49_RS03090	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
KBQ49_RS03095	COG2867	negative regulation of translational initiation
KBQ49_RS03105	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
KBQ49_RS03110	COG0735	belongs to the Fur family
KBQ49_RS03115	COG0497	DNA recombination
KBQ49_RS03120	COG1420	regulation of RNA biosynthetic process
KBQ49_RS03125	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
KBQ49_RS03130	COG0443	Heat shock 70 kDa protein
KBQ49_RS03135	COG0484	heat shock protein binding
KBQ49_RS03140	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
KBQ49_RS03145	COG1605	Chorismate mutase
KBQ49_RS03145	COG0287	Prephenate dehydrogenase
KBQ49_RS03155	COG1132	(ABC) transporter
KBQ49_RS03210	COG0567	Dehydrogenase, E1 component
KBQ49_RS03220	COG2850	peptidyl-arginine hydroxylation
KBQ49_RS03275	COG1131	(ABC) transporter
KBQ49_RS03280	COG1725	Transcriptional regulator
KBQ49_RS03290	COG0386	Belongs to the glutathione peroxidase family
KBQ49_RS03305	COG2900	Belongs to the SlyX family
KBQ49_RS03315	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
KBQ49_RS03315	COG2755	lipolytic protein G-D-S-L family
KBQ49_RS03325	COG0646	methionine synthase
KBQ49_RS03325	COG1410	methionine synthase
KBQ49_RS03330	COG0646	methionine synthase
KBQ49_RS03330	COG1410	methionine synthase
KBQ49_RS03335	COG2226	methyltransferase
KBQ49_RS03340	COG1960	acyl-CoA dehydrogenase activity
KBQ49_RS03385	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KBQ49_RS03395	COG2902	Dehydrogenase
KBQ49_RS03445	COG2925	Exonuclease
KBQ49_RS03455	COG3844	kynureninase activity
KBQ49_RS03470	COG0288	reversible hydration of carbon dioxide
KBQ49_RS03540	COG0316	Belongs to the HesB IscA family
KBQ49_RS03575	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KBQ49_RS03585	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
KBQ49_RS03595	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
KBQ49_RS03630	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
KBQ49_RS03645	COG1228	amidohydrolase
KBQ49_RS03660	COG4221	oxidoreductase activity
KBQ49_RS03700	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
KBQ49_RS03705	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
KBQ49_RS03710	COG0077	Prephenate dehydratase
KBQ49_RS03710	COG1605	Chorismate mutase
KBQ49_RS03735	COG0583	DNA-binding transcription factor activity
KBQ49_RS03780	COG0577	efflux transmembrane transporter activity
KBQ49_RS03780	COG1136	(ABC) transporter
KBQ49_RS03810	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KBQ49_RS03810	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KBQ49_RS03815	COG1105	Belongs to the carbohydrate kinase PfkB family
KBQ49_RS03820	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
KBQ49_RS03820	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
KBQ49_RS03825	COG1609	Transcriptional regulator
KBQ49_RS03835	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
KBQ49_RS03875	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KBQ49_RS03890	COG1253	flavin adenine dinucleotide binding
KBQ49_RS03900	COG0306	phosphate transporter
KBQ49_RS03925	COG0504	CTP synthase activity
KBQ49_RS03940	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
KBQ49_RS03945	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
KBQ49_RS03950	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
KBQ49_RS03965	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
KBQ49_RS03975	COG1238	metal cluster binding
KBQ49_RS03990	COG1534	Rna-binding protein
KBQ49_RS03995	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
KBQ49_RS04000	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KBQ49_RS04010	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
KBQ49_RS04015	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
KBQ49_RS04025	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
KBQ49_RS04030	COG1546	Belongs to the CinA family
KBQ49_RS04035	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
KBQ49_RS04040	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
KBQ49_RS04045	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
KBQ49_RS04050	COG2137	regulation of response to DNA damage stimulus
KBQ49_RS04110	COG1294	oxidase, subunit
KBQ49_RS04120	COG4988	ABC transporter
KBQ49_RS04125	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
KBQ49_RS04130	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
KBQ49_RS04180	COG4133	protoheme IX ABC transporter activity
KBQ49_RS04185	COG0436	Aminotransferase
KBQ49_RS04210	COG1187	pseudouridine synthase activity
KBQ49_RS04215	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
KBQ49_RS04220	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
KBQ49_RS04225	COG2350	Protein conserved in bacteria
KBQ49_RS04260	COG0395	ABC-type sugar transport system, permease component
KBQ49_RS04275	COG0129	dihydroxy-acid dehydratase activity
KBQ49_RS04290	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
KBQ49_RS04295	COG3842	ATPase activity
KBQ49_RS04300	COG0354	folic acid binding
KBQ49_RS04310	COG2009	succinate dehydrogenase
KBQ49_RS04315	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
KBQ49_RS04330	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
KBQ49_RS04340	COG4591	ABC-type transport system involved in lipoprotein release permease component
KBQ49_RS04360	COG0811	peptide transport
KBQ49_RS04370	COG1132	(ABC) transporter
KBQ49_RS04375	COG1663	tetraacyldisaccharide 4'-kinase activity
KBQ49_RS04385	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
KBQ49_RS04400	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
KBQ49_RS04410	COG0582	viral genome integration into host DNA
KBQ49_RS04415	COG0583	DNA-binding transcription factor activity
KBQ49_RS04620	COG2815	serine threonine protein kinase
KBQ49_RS04620	COG0515	serine threonine protein kinase
KBQ49_RS04630	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
KBQ49_RS04760	COG0270	DNA (cytosine-5-)-methyltransferase activity
KBQ49_RS04765	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
KBQ49_RS04770	COG0629	single-stranded DNA binding
KBQ49_RS04815	COG2207	Transcriptional regulator
KBQ49_RS04870	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
KBQ49_RS04875	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
KBQ49_RS04885	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KBQ49_RS04910	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KBQ49_RS04915	COG2258	MOSC domain
KBQ49_RS04925	COG0505	Belongs to the CarA family
KBQ49_RS04935	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
KBQ49_RS04940	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
KBQ49_RS04950	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
KBQ49_RS05040	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
KBQ49_RS05060	COG1024	Enoyl-CoA hydratase
KBQ49_RS05070	COG1024	Enoyl-CoA hydratase
KBQ49_RS05075	COG1024	Enoyl-CoA hydratase
KBQ49_RS05105	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KBQ49_RS05120	COG0346	lactoylglutathione lyase activity
KBQ49_RS05130	COG1304	FMN binding
KBQ49_RS05135	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
KBQ49_RS05140	COG1649	PFAM Uncharacterised BCR, COG1649
KBQ49_RS05210	COG0784	Response regulator, receiver
KBQ49_RS05210	COG2205	protein histidine kinase activity
KBQ49_RS05215	COG2183	response to ionizing radiation
KBQ49_RS05220	COG0784	Response regulator, receiver
KBQ49_RS05220	COG4191	Histidine kinase
KBQ49_RS05230	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KBQ49_RS05230	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
KBQ49_RS05250	COG3243	poly(R)-hydroxyalkanoic acid synthase
KBQ49_RS05260	COG1183	phosphatidylcholine synthase activity
KBQ49_RS05265	COG1028	Short-chain dehydrogenase reductase Sdr
KBQ49_RS05280	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
KBQ49_RS05290	COG0668	transmembrane transport
KBQ49_RS05295	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
KBQ49_RS05310	COG1914	H( )-stimulated, divalent metal cation uptake system
KBQ49_RS05320	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
KBQ49_RS05325	COG1501	Belongs to the glycosyl hydrolase 31 family
KBQ49_RS05380	COG0518	GMP synthase (glutamine-hydrolyzing) activity
KBQ49_RS05380	COG0519	Catalyzes the synthesis of GMP from XMP
KBQ49_RS05390	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
KBQ49_RS05405	COG0475	glutathione-regulated potassium exporter activity
KBQ49_RS05405	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
KBQ49_RS05410	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
KBQ49_RS05420	COG0746	molybdenum cofactor guanylyltransferase activity
KBQ49_RS05430	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
KBQ49_RS05440	COG1426	Protein conserved in bacteria
KBQ49_RS05450	COG0820	rRNA (adenine-C2-)-methyltransferase activity
KBQ49_RS05465	COG1250	3-hydroxyacyl-CoA dehydrogenase
KBQ49_RS05465	COG1024	Enoyl-CoA hydratase
KBQ49_RS05470	COG0183	Belongs to the thiolase family
KBQ49_RS05475	COG1210	Utp--glucose-1-phosphate uridylyltransferase
KBQ49_RS05485	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KBQ49_RS05490	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
KBQ49_RS05500	COG0776	regulation of translation
KBQ49_RS05505	COG0539	negative regulation of cytoplasmic translation
KBQ49_RS05510	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
KBQ49_RS05515	COG0257	Belongs to the bacterial ribosomal protein bL36 family
KBQ49_RS05525	COG2957	Belongs to the agmatine deiminase family
KBQ49_RS05530	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KBQ49_RS05550	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KBQ49_RS05570	COG0316	Belongs to the HesB IscA family
KBQ49_RS05570	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
KBQ49_RS05585	COG0428	transporter
KBQ49_RS05600	COG1530	ribonuclease E activity
KBQ49_RS05625	COG2801	Transposase and inactivated derivatives
KBQ49_RS05670	COG1022	Amp-dependent synthetase and ligase
KBQ49_RS05675	COG2801	Transposase and inactivated derivatives
KBQ49_RS05710	COG1132	(ABC) transporter
KBQ49_RS05730	COG0438	transferase activity, transferring glycosyl groups
KBQ49_RS05735	COG0438	transferase activity, transferring glycosyl groups
KBQ49_RS05755	COG4106	trans-aconitate 2-methyltransferase activity
KBQ49_RS05775	COG2244	polysaccharide biosynthetic process
KBQ49_RS05805	COG3038	cytochrome b561
KBQ49_RS05825	COG1595	DNA-templated transcription, initiation
KBQ49_RS05880	COG0038	chloride channel
KBQ49_RS05885	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
KBQ49_RS05905	COG1674	ftsk spoiiie
KBQ49_RS05910	COG0492	ferredoxin-NADP+ reductase activity
KBQ49_RS05930	COG0542	response to heat
KBQ49_RS05950	COG0482	sulfurtransferase activity
KBQ49_RS05955	COG2915	High frequency lysogenization protein hflD homolog
KBQ49_RS06015	COG0835	chemotaxis
KBQ49_RS06015	COG0784	Response regulator, receiver
KBQ49_RS06025	COG1558	bacterial-type flagellum-dependent cell motility
KBQ49_RS06035	COG1749	Flagellar hook protein flgE
KBQ49_RS06050	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
KBQ49_RS06065	COG4786	Flagellar basal body rod
KBQ49_RS06065	COG1256	bacterial-type flagellum assembly
KBQ49_RS06065	COG4786	Flagellar basal body rod
KBQ49_RS06065	COG1256	bacterial-type flagellum assembly
KBQ49_RS06070	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
KBQ49_RS06075	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
KBQ49_RS06080	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
KBQ49_RS06100	COG2197	response regulator
KBQ49_RS06105	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
KBQ49_RS06110	COG2201	protein-glutamate methylesterase activity
KBQ49_RS06130	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KBQ49_RS06135	COG1028	Short-chain dehydrogenase reductase Sdr
KBQ49_RS06140	COG1028	Short-chain dehydrogenase reductase Sdr
KBQ49_RS06190	COG1677	Flagellar hook-basal body complex protein FliE
KBQ49_RS06240	COG3190	flagellar
KBQ49_RS06250	COG1987	bacterial-type flagellum assembly
KBQ49_RS06255	COG1684	flagellar biosynthetic protein fliR
KBQ49_RS06300	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
KBQ49_RS06305	COG0643	Histidine kinase
KBQ49_RS06305	COG0784	Response regulator, receiver
KBQ49_RS06305	COG2198	Histidine kinase
KBQ49_RS06310	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
KBQ49_RS06320	COG1192	Involved in chromosome partitioning
KBQ49_RS06325	COG0835	chemotaxis
KBQ49_RS06335	COG0745	RESPONSE REGULATOR receiver
KBQ49_RS06350	COG0840	transmembrane signaling receptor activity
KBQ49_RS06355	COG0840	transmembrane signaling receptor activity
KBQ49_RS06360	COG0840	transmembrane signaling receptor activity
KBQ49_RS06365	COG0840	transmembrane signaling receptor activity
KBQ49_RS06375	COG0840	transmembrane signaling receptor activity
KBQ49_RS06385	COG0840	transmembrane signaling receptor activity
KBQ49_RS06390	COG0840	transmembrane signaling receptor activity
KBQ49_RS06395	COG0840	transmembrane signaling receptor activity
KBQ49_RS06405	COG0840	transmembrane signaling receptor activity
KBQ49_RS06415	COG0835	chemotaxis
KBQ49_RS06425	COG0840	transmembrane signaling receptor activity
KBQ49_RS06435	COG0840	transmembrane signaling receptor activity
KBQ49_RS06460	COG3706	GGDEF domain
KBQ49_RS06490	COG0318	PFAM AMP-dependent synthetase and ligase
KBQ49_RS06495	COG1024	Enoyl-CoA hydratase
KBQ49_RS06500	COG0784	Response regulator, receiver
KBQ49_RS06500	COG2198	Histidine kinase
KBQ49_RS06500	COG2205	protein histidine kinase activity
KBQ49_RS06535	COG0800	Aldolase
KBQ49_RS06550	COG3734	2-keto-3-deoxy-galactonokinase
KBQ49_RS06555	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
KBQ49_RS06565	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KBQ49_RS06575	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
KBQ49_RS06580	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
KBQ49_RS06595	COG0351	phosphomethylpyrimidine kinase
KBQ49_RS06615	COG0583	DNA-binding transcription factor activity
KBQ49_RS06620	COG1741	Belongs to the pirin family
KBQ49_RS06665	COG1024	Enoyl-CoA hydratase
KBQ49_RS06680	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
KBQ49_RS06700	COG0277	FAD linked oxidase domain protein
KBQ49_RS06705	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KBQ49_RS06720	COG0531	amino acid
KBQ49_RS06725	COG0531	amino acid
KBQ49_RS06735	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
KBQ49_RS06740	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
KBQ49_RS06760	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
KBQ49_RS06760	COG0140	phosphoribosyl-ATP diphosphatase activity
KBQ49_RS06775	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
KBQ49_RS06785	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KBQ49_RS06790	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
KBQ49_RS06795	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
KBQ49_RS06805	COG0124	histidyl-tRNA synthetase
KBQ49_RS06810	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KBQ49_RS06820	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
KBQ49_RS06830	COG2951	lytic endotransglycosylase activity
KBQ49_RS06840	COG0460	homoserine dehydrogenase
KBQ49_RS06840	COG0527	aspartate kinase activity
KBQ49_RS06850	COG1012	belongs to the aldehyde dehydrogenase family
KBQ49_RS06865	COG0167	dihydroorotate dehydrogenase activity
KBQ49_RS06870	COG0812	UDP-N-acetylmuramate dehydrogenase activity
KBQ49_RS06900	COG0671	phosphoesterase, PA-phosphatase related
KBQ49_RS06915	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
KBQ49_RS06950	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
KBQ49_RS06960	COG0617	tRNA 3'-terminal CCA addition
KBQ49_RS06980	COG0860	N-Acetylmuramoyl-L-alanine amidase
KBQ49_RS06985	COG0477	Major facilitator Superfamily
KBQ49_RS06990	COG2115	Belongs to the xylose isomerase family
KBQ49_RS06995	COG1070	Carbohydrate kinase
KBQ49_RS07005	COG1501	Belongs to the glycosyl hydrolase 31 family
KBQ49_RS07030	COG2801	Transposase and inactivated derivatives
KBQ49_RS07040	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
KBQ49_RS07060	COG0165	Argininosuccinate lyase
KBQ49_RS07065	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
KBQ49_RS07075	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
KBQ49_RS07080	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KBQ49_RS07085	COG0137	argininosuccinate synthase activity
KBQ49_RS07090	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
KBQ49_RS07105	COG2166	iron-sulfur cluster assembly
KBQ49_RS07135	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
KBQ49_RS07150	COG4677	pectinesterase activity
KBQ49_RS07180	COG0402	S-adenosylhomocysteine deaminase activity
KBQ49_RS07185	COG3548	integral membrane protein
KBQ49_RS07195	COG1509	lysine 2,3-aminomutase activity
KBQ49_RS07200	COG2203	Gaf domain
KBQ49_RS07200	COG3706	GGDEF domain
KBQ49_RS07200	COG4251	negative regulation of phosphorylation
KBQ49_RS07200	COG5001	Diguanylate cyclase
KBQ49_RS07230	COG1862	Preprotein translocase
KBQ49_RS07240	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
KBQ49_RS07250	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KBQ49_RS07265	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
KBQ49_RS07270	COG3291	Pkd domain containing protein
KBQ49_RS07275	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KBQ49_RS07280	COG0405	Gamma-glutamyltransferase
KBQ49_RS07285	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
KBQ49_RS07300	COG0742	ribosomal rna small subunit methyltransferase
KBQ49_RS07325	COG4771	TonB-dependent receptor
KBQ49_RS07335	COG3507	Belongs to the glycosyl hydrolase 43 family
KBQ49_RS07345	COG4206	TonB-dependent receptor
KBQ49_RS07370	COG0531	amino acid
KBQ49_RS07385	COG0006	proline dipeptidase activity
KBQ49_RS07395	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KBQ49_RS07410	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KBQ49_RS07415	COG3938	Belongs to the proline racemase family
KBQ49_RS07425	COG0552	protein localization to endoplasmic reticulum
KBQ49_RS07475	COG0835	chemotaxis
KBQ49_RS07480	COG0840	transmembrane signaling receptor activity
KBQ49_RS07485	COG0840	transmembrane signaling receptor activity
KBQ49_RS07505	COG3300	MHYT domain
KBQ49_RS07505	COG5001	Diguanylate cyclase
KBQ49_RS07515	COG1185	polyribonucleotide nucleotidyltransferase activity
KBQ49_RS07540	COG0195	Participates in both transcription termination and antitermination
KBQ49_RS07555	COG1007	ATP synthesis coupled electron transport
KBQ49_RS07595	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
KBQ49_RS07600	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
KBQ49_RS07605	COG0649	NAD binding
KBQ49_RS07610	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KBQ49_RS07620	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KBQ49_RS07650	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
KBQ49_RS07710	COG2890	protein-(glutamine-N5) methyltransferase activity
KBQ49_RS07720	COG0688	phosphatidylethanolamine metabolic process
KBQ49_RS07725	COG0741	lytic transglycosylase activity
KBQ49_RS07730	COG0433	COG0433 Predicted ATPase
KBQ49_RS07735	COG0494	nUDIX hydrolase
KBQ49_RS07750	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
KBQ49_RS07770	COG1714	RDD family
KBQ49_RS07775	COG0717	Belongs to the dCTP deaminase family
KBQ49_RS07780	COG0489	protein tyrosine kinase activity
KBQ49_RS07790	COG4771	TonB-dependent receptor
KBQ49_RS07800	COG4771	TonB-dependent receptor
KBQ49_RS07805	COG0457	Tetratricopeptide repeat
KBQ49_RS07820	COG3590	peptidase
KBQ49_RS07860	COG0697	spore germination
KBQ49_RS07880	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KBQ49_RS07885	COG2311	Membrane
KBQ49_RS07890	COG1047	Peptidyl-prolyl cis-trans
KBQ49_RS07895	COG0791	NLP P60 protein
KBQ49_RS07900	COG0791	NLP P60 protein
KBQ49_RS07910	COG1607	acyl-coa hydrolase
KBQ49_RS07920	COG1301	dicarboxylic acid transport
KBQ49_RS07925	COG1785	Belongs to the alkaline phosphatase family
KBQ49_RS07935	COG0037	tRNA processing
KBQ49_RS07940	COG1722	exodeoxyribonuclease VII activity
KBQ49_RS07945	COG0142	geranyltranstransferase activity
KBQ49_RS07955	COG1858	cytochrome C peroxidase
KBQ49_RS07980	COG0515	serine threonine protein kinase
KBQ49_RS07980	COG2815	serine threonine protein kinase
KBQ49_RS07985	COG0631	protein serine/threonine phosphatase activity
KBQ49_RS08080	COG0312	modulator of DNA gyrase
KBQ49_RS08090	COG0312	modulator of DNA gyrase
KBQ49_RS08110	COG2968	Membrane
KBQ49_RS08125	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
KBQ49_RS08140	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
KBQ49_RS08155	COG0495	leucyl-tRNA aminoacylation
KBQ49_RS08165	COG3118	belongs to the thioredoxin family
KBQ49_RS08180	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
KBQ49_RS08190	COG2040	homocysteine
KBQ49_RS08195	COG0833	amino acid
KBQ49_RS08205	COG0346	lactoylglutathione lyase activity
KBQ49_RS08225	COG2878	Part of a membrane complex involved in electron transport
KBQ49_RS08240	COG1595	DNA-templated transcription, initiation
KBQ49_RS08265	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
KBQ49_RS08285	COG0251	oxidation-reduction process
KBQ49_RS08295	COG0392	lysyltransferase activity
KBQ49_RS08295	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
KBQ49_RS08325	COG2814	Major facilitator Superfamily
KBQ49_RS08330	COG1902	pentaerythritol trinitrate reductase activity
KBQ49_RS08335	COG2824	Alkylphosphonate utilization operon protein PhnA
KBQ49_RS08340	COG1047	Peptidyl-prolyl cis-trans
KBQ49_RS08345	COG1077	Cell shape determining protein MreB Mrl
KBQ49_RS08380	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
KBQ49_RS08390	COG1451	nucleotide metabolic process
KBQ49_RS08410	COG0784	Response regulator, receiver
KBQ49_RS08410	COG2198	Histidine kinase
KBQ49_RS08410	COG2205	protein histidine kinase activity
KBQ49_RS08420	COG2186	Transcriptional regulator
KBQ49_RS08425	COG3250	beta-galactosidase activity
KBQ49_RS08490	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
KBQ49_RS08490	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
KBQ49_RS08490	COG1703	isobutyryl-CoA mutase activity
KBQ49_RS08520	COG0183	Belongs to the thiolase family
KBQ49_RS08530	COG0443	Heat shock 70 kDa protein
KBQ49_RS08560	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
KBQ49_RS08560	COG1793	dna ligase
KBQ49_RS08565	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
KBQ49_RS08565	COG1793	dna ligase
KBQ49_RS08570	COG1201	RNA secondary structure unwinding
KBQ49_RS08580	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KBQ49_RS08585	COG1278	Cold shock
KBQ49_RS08590	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
KBQ49_RS08595	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
KBQ49_RS08600	COG1472	Belongs to the glycosyl hydrolase 3 family
KBQ49_RS08610	COG2954	triphosphatase activity
KBQ49_RS08620	COG0745	RESPONSE REGULATOR receiver
KBQ49_RS08625	COG1381	Involved in DNA repair and RecF pathway recombination
KBQ49_RS08630	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
KBQ49_RS08645	COG0681	Belongs to the peptidase S26 family
KBQ49_RS08650	COG0481	GTPase activity
KBQ49_RS08655	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KBQ49_RS08670	COG1024	Enoyl-CoA hydratase
KBQ49_RS08670	COG1250	3-hydroxyacyl-CoA dehydrogenase
KBQ49_RS08690	COG2855	membrane
KBQ49_RS08705	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
KBQ49_RS08725	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
KBQ49_RS08735	COG0534	Mate efflux family protein
KBQ49_RS08740	COG0335	large ribosomal subunit rRNA binding
KBQ49_RS08745	COG0336	Belongs to the RNA methyltransferase TrmD family
KBQ49_RS08750	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
KBQ49_RS08755	COG0228	four-way junction DNA binding
KBQ49_RS08765	COG2070	2-Nitropropane dioxygenase
KBQ49_RS08770	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
KBQ49_RS08795	COG0475	glutathione-regulated potassium exporter activity
KBQ49_RS08805	COG0625	glutathione transferase activity
KBQ49_RS08810	COG1082	Xylose isomerase domain protein TIM barrel
KBQ49_RS08820	COG1172	Belongs to the binding-protein-dependent transport system permease family
KBQ49_RS08825	COG1172	Belongs to the binding-protein-dependent transport system permease family
KBQ49_RS08830	COG1129	ABC transporter
KBQ49_RS08835	COG1879	ABC-type sugar transport system periplasmic component
KBQ49_RS08840	COG1012	belongs to the aldehyde dehydrogenase family
KBQ49_RS08860	COG0129	dihydroxy-acid dehydratase activity
KBQ49_RS08890	COG2207	Transcriptional regulator
KBQ49_RS08935	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
KBQ49_RS08960	COG4794	Type iii secretion
KBQ49_RS08990	COG0745	RESPONSE REGULATOR receiver
KBQ49_RS09045	COG0156	8-amino-7-oxononanoate synthase activity
KBQ49_RS09055	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
KBQ49_RS09060	COG1845	cytochrome c oxidase, subunit III
KBQ49_RS09065	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
KBQ49_RS09090	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
KBQ49_RS09105	COG0196	riboflavin kinase activity
KBQ49_RS09115	COG0728	peptidoglycan biosynthetic process
KBQ49_RS09125	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
KBQ49_RS09130	COG0211	Belongs to the bacterial ribosomal protein bL27 family
KBQ49_RS09135	COG0261	This protein binds to 23S rRNA in the presence of protein L20
KBQ49_RS09140	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
KBQ49_RS09145	COG0824	Thioesterase
KBQ49_RS09155	COG1024	Enoyl-CoA hydratase
KBQ49_RS09160	COG1946	Acyl-CoA thioesterase
KBQ49_RS09220	COG1073	alpha beta
KBQ49_RS09245	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
KBQ49_RS09290	COG1643	Atp-dependent helicase
KBQ49_RS09295	COG0783	Belongs to the Dps family
KBQ49_RS09300	COG0514	ATP-dependent DNA helicase (RecQ)
KBQ49_RS09320	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
KBQ49_RS09325	COG0602	queuosine metabolic process
KBQ49_RS09335	COG2885	chlorophyll binding
KBQ49_RS09350	COG0848	biopolymer transport protein
KBQ49_RS09360	COG0824	Thioesterase
KBQ49_RS09365	COG2255	four-way junction helicase activity
KBQ49_RS09370	COG3158	transport of potassium into the cell
KBQ49_RS09375	COG0632	four-way junction helicase activity
KBQ49_RS09385	COG0217	transcriptional regulatory protein
KBQ49_RS09425	COG3142	Participates in the control of copper homeostasis
KBQ49_RS09430	COG1446	asparaginase
KBQ49_RS09480	COG2201	protein-glutamate methylesterase activity
KBQ49_RS09485	COG2198	Histidine kinase
KBQ49_RS09485	COG0784	Response regulator, receiver
KBQ49_RS09485	COG0643	Histidine kinase
KBQ49_RS09490	COG0840	transmembrane signaling receptor activity
KBQ49_RS09495	COG0835	chemotaxis
KBQ49_RS09510	COG0189	ligase activity
KBQ49_RS09530	COG1199	ATP-dependent helicase activity
KBQ49_RS09540	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KBQ49_RS09545	COG1216	Glycosyl transferase, family 2
KBQ49_RS09550	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
KBQ49_RS09570	COG4585	Histidine kinase
KBQ49_RS09580	COG0850	regulation of cytokinetic process
KBQ49_RS09585	COG2894	cell division
KBQ49_RS09590	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
KBQ49_RS09600	COG2205	protein histidine kinase activity
KBQ49_RS09605	COG0745	RESPONSE REGULATOR receiver
KBQ49_RS09615	COG2194	sulfuric ester hydrolase activity
KBQ49_RS09720	COG2814	Major facilitator Superfamily
KBQ49_RS09745	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
KBQ49_RS09745	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
KBQ49_RS09760	COG0753	catalase activity
KBQ49_RS09785	COG1063	alcohol dehydrogenase
KBQ49_RS09795	COG3459	Glycosyltransferase 36 associated
KBQ49_RS09905	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
KBQ49_RS09935	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
KBQ49_RS09945	COG0330	HflC and HflK could
KBQ49_RS09950	COG0330	HflC and HflK could
KBQ49_RS09955	COG0604	alcohol dehydrogenase
KBQ49_RS09980	COG0678	peroxiredoxin activity
KBQ49_RS09990	COG4953	penicillin-binding protein 1C
KBQ49_RS10010	COG2373	Large extracellular alpha-helical protein
KBQ49_RS10060	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
KBQ49_RS10075	COG0372	Belongs to the citrate synthase family
KBQ49_RS10100	COG2161	toxin-antitoxin pair type II binding
KBQ49_RS10105	COG4115	mRNA cleavage
KBQ49_RS10125	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
KBQ49_RS10130	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
KBQ49_RS10135	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
KBQ49_RS10145	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KBQ49_RS10150	COG1028	Short-chain dehydrogenase reductase Sdr
KBQ49_RS10155	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
KBQ49_RS10160	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KBQ49_RS10170	COG1399	metal-binding, possibly nucleic acid-binding protein
KBQ49_RS10195	COG0714	Associated with various cellular activities
KBQ49_RS10215	COG0537	adenosine 5'-monophosphoramidase activity
KBQ49_RS10245	COG0314	molybdopterin synthase activity
KBQ49_RS10250	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
KBQ49_RS10255	COG0315	cyclic pyranopterin monophosphate synthase activity
KBQ49_RS10265	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
KBQ49_RS10270	COG1234	tRNA 3'-trailer cleavage
KBQ49_RS10280	COG0859	PFAM glycosyl transferase family 9
KBQ49_RS10305	COG0631	protein serine/threonine phosphatase activity
KBQ49_RS10310	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
KBQ49_RS10315	COG0328	RNA-DNA hybrid ribonuclease activity
KBQ49_RS10325	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KBQ49_RS10330	COG3942	CHAP domain
KBQ49_RS10330	COG1388	LysM domain
KBQ49_RS10370	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
KBQ49_RS10380	COG0544	peptidyl-prolyl cis-trans isomerase activity
KBQ49_RS10420	COG0473	3-isopropylmalate dehydrogenase activity
KBQ49_RS10435	COG4783	chaperone-mediated protein folding
KBQ49_RS10450	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
KBQ49_RS10455	COG0248	Ppx GppA phosphatase
KBQ49_RS10460	COG0438	transferase activity, transferring glycosyl groups
KBQ49_RS10470	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KBQ49_RS10505	COG0285	dihydrofolate synthase activity
KBQ49_RS10510	COG0588	phosphoglycerate mutase activity
KBQ49_RS10530	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
KBQ49_RS10535	COG4208	sulfate ABC transporter
KBQ49_RS10540	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
KBQ49_RS10545	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
KBQ49_RS10550	COG0156	8-amino-7-oxononanoate synthase activity
KBQ49_RS10570	COG2885	chlorophyll binding
KBQ49_RS10590	COG0667	Aldo Keto reductase
KBQ49_RS10605	COG0446	pyridine nucleotide-disulphide oxidoreductase
KBQ49_RS10605	COG1902	pentaerythritol trinitrate reductase activity
KBQ49_RS10650	COG0625	glutathione transferase activity
KBQ49_RS10665	COG0039	L-malate dehydrogenase activity
KBQ49_RS10675	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
KBQ49_RS10680	COG1217	gtp-binding protein TYPA
KBQ49_RS10695	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
KBQ49_RS10705	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
KBQ49_RS10710	COG0203	ribosomal protein L17
KBQ49_RS10735	COG0201	protein transport
KBQ49_RS10745	COG1841	ribosomal large subunit assembly
KBQ49_RS10770	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
KBQ49_RS10775	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
KBQ49_RS10780	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
KBQ49_RS10790	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
KBQ49_RS10795	COG0255	Belongs to the universal ribosomal protein uL29 family
KBQ49_RS10820	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
KBQ49_RS10825	COG0089	rRNA binding
KBQ49_RS10830	COG0088	Forms part of the polypeptide exit tunnel
KBQ49_RS10840	COG0051	transcription antitermination factor activity, RNA binding
KBQ49_RS10845	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
KBQ49_RS10850	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
KBQ49_RS10865	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
KBQ49_RS10875	COG0222	ribosome binding
KBQ49_RS10890	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
KBQ49_RS10895	COG0250	Participates in transcription elongation, termination and antitermination
KBQ49_RS10900	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
KBQ49_RS10910	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
KBQ49_RS10930	COG0012	GTP binding
KBQ49_RS10935	COG0193	aminoacyl-tRNA hydrolase activity
KBQ49_RS10945	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
KBQ49_RS10955	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
KBQ49_RS10970	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
KBQ49_RS10975	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
KBQ49_RS11015	COG0488	(ABC) transporter
KBQ49_RS11100	COG4651	solute:proton antiporter activity
KBQ49_RS11100	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
KBQ49_RS11115	COG4772	TonB-dependent receptor
KBQ49_RS11125	COG4264	IucA IucC family
KBQ49_RS11130	COG2814	Major facilitator Superfamily
KBQ49_RS11135	COG4264	IucA IucC family
KBQ49_RS11140	COG0019	diaminopimelate decarboxylase activity
KBQ49_RS11165	COG0542	response to heat
KBQ49_RS11195	COG0454	-acetyltransferase
KBQ49_RS11220	COG3387	PFAM Glycoside hydrolase 15-related
KBQ49_RS11245	COG0564	pseudouridine synthase activity
KBQ49_RS11250	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
KBQ49_RS11260	COG1125	glycine betaine transport
KBQ49_RS11265	COG1174	glycine betaine transport
KBQ49_RS11280	COG1262	PFAM Formylglycine-generating sulfatase enzyme
KBQ49_RS11290	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KBQ49_RS11290	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
KBQ49_RS11295	COG4993	Dehydrogenase
KBQ49_RS11300	COG4993	Dehydrogenase
KBQ49_RS11335	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
KBQ49_RS11365	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
KBQ49_RS11380	COG0745	RESPONSE REGULATOR receiver
KBQ49_RS11390	COG0189	ligase activity
KBQ49_RS11400	COG3511	phospholipase C
KBQ49_RS11420	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
KBQ49_RS11435	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
KBQ49_RS11445	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
KBQ49_RS11450	COG0174	glutamine synthetase
KBQ49_RS11475	COG2022	thiamine diphosphate biosynthetic process
KBQ49_RS11485	COG3273	potassium ion transport
KBQ49_RS11485	COG0471	metal ion transport
KBQ49_RS11500	COG0179	Fumarylacetoacetate (FAA) hydrolase
KBQ49_RS11515	COG1609	Transcriptional regulator
KBQ49_RS11525	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KBQ49_RS11565	COG0840	transmembrane signaling receptor activity
KBQ49_RS11570	COG0529	Catalyzes the synthesis of activated sulfate
KBQ49_RS11570	COG2895	sulfate adenylyltransferase (ATP) activity
KBQ49_RS11575	COG0175	sulfate reduction
KBQ49_RS11585	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KBQ49_RS11590	COG0175	sulfate reduction
KBQ49_RS11620	COG1393	Belongs to the ArsC family
KBQ49_RS11640	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
KBQ49_RS11640	COG1648	precorrin-2 dehydrogenase activity
KBQ49_RS11655	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
KBQ49_RS11695	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
KBQ49_RS11700	COG3588	fructose-bisphosphate aldolase
KBQ49_RS11705	COG0469	pyruvate kinase activity
KBQ49_RS11760	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
KBQ49_RS11765	COG3047	cAMP biosynthetic process
KBQ49_RS11785	COG0640	Transcriptional regulator
KBQ49_RS11795	COG0725	ABC transporter, periplasmic molybdate-binding protein
KBQ49_RS11800	COG4149	molybdate abc transporter
KBQ49_RS11805	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
KBQ49_RS11830	COG1376	ErfK ybiS ycfS ynhG family protein
KBQ49_RS11835	COG0739	heme binding
KBQ49_RS11865	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
KBQ49_RS11870	COG1301	dicarboxylic acid transport
KBQ49_RS11900	COG0714	Associated with various cellular activities
KBQ49_RS11930	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
KBQ49_RS11945	COG0372	Belongs to the citrate synthase family
KBQ49_RS11950	COG0254	rRNA binding
KBQ49_RS11960	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
KBQ49_RS11970	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
KBQ49_RS11975	COG1758	RNA polymerase activity
KBQ49_RS11980	COG0194	GDP metabolic process
KBQ49_RS11985	COG1561	YicC-like family, N-terminal region
KBQ49_RS11990	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
KBQ49_RS11995	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
KBQ49_RS12000	COG0635	Involved in the biosynthesis of porphyrin-containing compound
KBQ49_RS12030	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
KBQ49_RS12095	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
KBQ49_RS12105	COG0494	nUDIX hydrolase
KBQ49_RS12155	COG0739	heme binding
KBQ49_RS12170	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
KBQ49_RS12180	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
KBQ49_RS12185	COG1181	Belongs to the D-alanine--D-alanine ligase family
KBQ49_RS12195	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
KBQ49_RS12210	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
KBQ49_RS12225	COG3116	cell division
KBQ49_RS12230	COG0275	rRNA processing
KBQ49_RS12235	COG2001	Belongs to the MraZ family
KBQ49_RS12270	COG0792	nuclease activity
KBQ49_RS12280	COG0277	FAD linked oxidase domain protein
KBQ49_RS12285	COG0745	RESPONSE REGULATOR receiver
KBQ49_RS12290	COG2205	protein histidine kinase activity
KBQ49_RS12300	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
KBQ49_RS12305	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
KBQ49_RS12335	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KBQ49_RS12340	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
KBQ49_RS12360	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KBQ49_RS12360	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KBQ49_RS12370	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
KBQ49_RS12390	COG0488	(ABC) transporter
KBQ49_RS12395	COG0242	peptide deformylase activity
KBQ49_RS12420	COG1215	transferase activity, transferring glycosyl groups
KBQ49_RS12430	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
KBQ49_RS12480	COG2188	Transcriptional regulator
KBQ49_RS12490	COG1450	Type ii and iii secretion system protein
KBQ49_RS12505	COG3166	PFAM Fimbrial assembly family protein
KBQ49_RS12510	COG3156	type II secretion system protein K
KBQ49_RS12515	COG4795	General secretion pathway protein
KBQ49_RS12520	COG2165	general secretion pathway protein
KBQ49_RS12525	COG4970	Tfp pilus assembly protein FimT
KBQ49_RS12530	COG2165	general secretion pathway protein
KBQ49_RS12535	COG1459	type II secretion system
KBQ49_RS12540	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
KBQ49_RS12545	COG1404	Belongs to the peptidase S8 family
KBQ49_RS12550	COG5295	Hep Hag repeat protein
KBQ49_RS12560	COG0840	transmembrane signaling receptor activity
KBQ49_RS12570	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
KBQ49_RS12575	COG4974	Belongs to the 'phage' integrase family
KBQ49_RS12600	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
KBQ49_RS12630	COG1183	phosphatidylcholine synthase activity
KBQ49_RS12640	COG0442	prolyl-tRNA aminoacylation
KBQ49_RS12655	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
KBQ49_RS12660	COG1127	ABC transporter
KBQ49_RS12665	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
KBQ49_RS12665	COG3218	ABC-type transport auxiliary lipoprotein component
KBQ49_RS12695	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
KBQ49_RS12700	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KBQ49_RS12705	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
KBQ49_RS12705	COG0662	Cupin 2, conserved barrel domain protein
KBQ49_RS12730	COG2086	electron transfer activity
KBQ49_RS12745	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
KBQ49_RS12745	COG0546	phosphoglycolate phosphatase activity
KBQ49_RS12750	COG0277	FAD linked oxidase domain protein
KBQ49_RS12755	COG0300	oxidoreductase activity
KBQ49_RS12760	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KBQ49_RS12820	COG0438	transferase activity, transferring glycosyl groups
KBQ49_RS12820	COG1216	Glycosyl transferase, family 2
KBQ49_RS12825	COG0438	transferase activity, transferring glycosyl groups
KBQ49_RS12825	COG1216	Glycosyl transferase, family 2
KBQ49_RS12830	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
KBQ49_RS12845	COG0626	cystathionine gamma-synthase activity
KBQ49_RS12875	COG0625	glutathione transferase activity
KBQ49_RS12890	COG0720	synthase
KBQ49_RS12900	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
KBQ49_RS12905	COG1956	GAF domain-containing protein
KBQ49_RS12915	COG4206	TonB-dependent receptor
KBQ49_RS12920	COG0546	phosphoglycolate phosphatase activity
KBQ49_RS12945	COG0339	signal peptide processing
KBQ49_RS12950	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KBQ49_RS12960	COG2217	Heavy metal translocating P-type atpase
KBQ49_RS12975	COG2132	Multicopper oxidase
KBQ49_RS12990	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
KBQ49_RS13000	COG1136	(ABC) transporter
KBQ49_RS13005	COG1136	(ABC) transporter
KBQ49_RS13005	COG0577	efflux transmembrane transporter activity
KBQ49_RS13010	COG0577	efflux transmembrane transporter activity
KBQ49_RS13010	COG1136	(ABC) transporter
KBQ49_RS13020	COG4191	Histidine kinase
KBQ49_RS13030	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
KBQ49_RS13050	COG0355	proton-transporting ATP synthase activity, rotational mechanism
KBQ49_RS13065	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
KBQ49_RS13075	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
KBQ49_RS13085	COG0356	it plays a direct role in the translocation of protons across the membrane
KBQ49_RS13100	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KBQ49_RS13105	COG0508	dehydrogenase complex catalyzes the overall conversion of
KBQ49_RS13140	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
KBQ49_RS13145	COG0697	spore germination
KBQ49_RS13150	COG1666	GTP binding
KBQ49_RS13160	COG1187	pseudouridine synthase activity
KBQ49_RS13185	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KBQ49_RS13185	COG2205	protein histidine kinase activity
KBQ49_RS13210	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KBQ49_RS13270	COG0842	Transport permease protein
KBQ49_RS13275	COG1131	(ABC) transporter
KBQ49_RS13280	COG0025	NhaP-type Na H and K H
KBQ49_RS13290	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
KBQ49_RS13295	COG1573	uracil-dna glycosylase
KBQ49_RS13310	COG3384	dioxygenase
KBQ49_RS13345	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KBQ49_RS13350	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KBQ49_RS13370	COG3706	GGDEF domain
KBQ49_RS13380	COG5001	Diguanylate cyclase
KBQ49_RS13410	COG4106	trans-aconitate 2-methyltransferase activity
KBQ49_RS13420	COG2076	Multidrug Resistance protein
KBQ49_RS13430	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
KBQ49_RS13460	COG3275	phosphorelay sensor kinase activity
KBQ49_RS13465	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
KBQ49_RS13485	COG0531	amino acid
KBQ49_RS13495	COG5297	Belongs to the glycosyl hydrolase family 6
KBQ49_RS13495	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
KBQ49_RS13510	COG0741	lytic transglycosylase activity
KBQ49_RS13525	COG2207	Transcriptional regulator
KBQ49_RS13535	COG0598	Magnesium transport protein CorA
KBQ49_RS13540	COG1113	amino acid transport
KBQ49_RS13545	COG0697	spore germination
KBQ49_RS13555	COG0583	DNA-binding transcription factor activity
KBQ49_RS13570	COG2267	carboxylic ester hydrolase activity
KBQ49_RS13720	COG0840	transmembrane signaling receptor activity
KBQ49_RS13735	COG2353	YceI-like domain
KBQ49_RS13760	COG0584	glycerophosphoryl diester phosphodiesterase
KBQ49_RS13775	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
KBQ49_RS13795	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
KBQ49_RS13800	COG0459	protein refolding
KBQ49_RS13820	COG1324	tolerance protein
KBQ49_RS13825	COG4232	protein-disulfide reductase activity
KBQ49_RS13830	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KBQ49_RS13840	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
KBQ49_RS13845	COG0511	ligase activity, forming carbon-carbon bonds
KBQ49_RS13850	COG0439	Biotin carboxylase
KBQ49_RS13885	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
KBQ49_RS13890	COG4589	Belongs to the CDS family
KBQ49_RS13915	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
KBQ49_RS13920	COG0138	bifunctional purine biosynthesis protein purh
KBQ49_RS13925	COG0151	Belongs to the GarS family
KBQ49_RS13930	COG1289	transmembrane transporter activity
KBQ49_RS13935	COG2814	Major facilitator Superfamily
KBQ49_RS13975	COG2816	NAD+ diphosphatase activity
KBQ49_RS14015	COG2906	2 iron, 2 sulfur cluster binding
KBQ49_RS14020	COG1051	belongs to the nudix hydrolase family
KBQ49_RS14045	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
KBQ49_RS14060	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
KBQ49_RS14065	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KBQ49_RS14070	COG0730	response to heat
KBQ49_RS14080	COG0134	indole-3-glycerol-phosphate synthase activity
KBQ49_RS14085	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
KBQ49_RS14105	COG1597	lipid kinase activity
KBQ49_RS14120	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
KBQ49_RS14135	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KBQ49_RS14140	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
KBQ49_RS14140	COG2111	Na H antiporter
KBQ49_RS14145	COG1006	Multisubunit Na H antiporter MnhC subunit
KBQ49_RS14150	COG0651	ATP synthesis coupled electron transport
KBQ49_RS14155	COG1863	multisubunit Na H antiporter MnhE subunit
KBQ49_RS14160	COG2212	antiporter activity
KBQ49_RS14165	COG1320	monovalent cation:proton antiporter activity
KBQ49_RS14170	COG0530	calcium, potassium:sodium antiporter activity
KBQ49_RS14185	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
KBQ49_RS14205	COG3104	oligopeptide transport
KBQ49_RS14225	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
KBQ49_RS14240	COG0508	dehydrogenase complex catalyzes the overall conversion of
KBQ49_RS14250	COG3227	Zinc metalloprotease (Elastase)
KBQ49_RS14255	COG0513	Belongs to the DEAD box helicase family
KBQ49_RS14290	COG2354	Protein conserved in bacteria
KBQ49_RS14310	COG3264	Mechanosensitive ion channel
KBQ49_RS14310	COG1196	nuclear chromosome segregation
KBQ49_RS14315	COG3321	synthase
KBQ49_RS14315	COG0604	alcohol dehydrogenase
KBQ49_RS14315	COG1028	Short-chain dehydrogenase reductase Sdr
KBQ49_RS14335	COG1595	DNA-templated transcription, initiation
KBQ49_RS14350	COG1802	Transcriptional regulator
KBQ49_RS14365	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
KBQ49_RS14395	COG1414	Transcriptional regulator
KBQ49_RS14400	COG0738	Major facilitator superfamily
KBQ49_RS14405	COG3254	rhamnose metabolic process
KBQ49_RS14415	COG4948	Mandelate Racemase Muconate Lactonizing
KBQ49_RS14420	COG0179	Fumarylacetoacetate (FAA) hydrolase
KBQ49_RS14425	COG1028	Short-chain dehydrogenase reductase Sdr
KBQ49_RS14455	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
KBQ49_RS14470	COG4807	Protein conserved in bacteria
KBQ49_RS14490	COG4773	Receptor
KBQ49_RS14505	COG0823	Involved in the tonB-independent uptake of proteins
KBQ49_RS14505	COG1506	peptidase
KBQ49_RS14585	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KBQ49_RS14610	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KBQ49_RS14615	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
KBQ49_RS14620	COG0753	catalase activity
KBQ49_RS14645	COG1136	(ABC) transporter
KBQ49_RS14650	COG0577	efflux transmembrane transporter activity
KBQ49_RS14670	COG0697	spore germination
KBQ49_RS14685	COG0180	Tryptophanyl-tRNA synthetase
KBQ49_RS14720	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
KBQ49_RS14725	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
KBQ49_RS14725	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
KBQ49_RS14735	COG3228	Belongs to the MtfA family
KBQ49_RS14765	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KBQ49_RS14790	COG2084	Dehydrogenase
KBQ49_RS14795	COG1902	pentaerythritol trinitrate reductase activity
KBQ49_RS14805	COG2814	Major facilitator Superfamily
KBQ49_RS14810	COG0583	DNA-binding transcription factor activity
KBQ49_RS14825	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KBQ49_RS14830	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KBQ49_RS14840	COG1764	response to oxidative stress
KBQ49_RS14845	COG1846	Transcriptional regulator
KBQ49_RS14850	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
KBQ49_RS14860	COG0697	spore germination
KBQ49_RS14865	COG0523	cobalamin synthesis protein
KBQ49_RS14875	COG1742	UPF0060 membrane protein
KBQ49_RS14885	COG3245	cytochrome
KBQ49_RS14895	COG1960	acyl-CoA dehydrogenase activity
KBQ49_RS14900	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
KBQ49_RS14920	COG1278	Cold shock
KBQ49_RS14935	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
KBQ49_RS14940	COG3387	PFAM Glycoside hydrolase 15-related
KBQ49_RS14945	COG0745	RESPONSE REGULATOR receiver
KBQ49_RS14975	COG1404	Belongs to the peptidase S8 family
KBQ49_RS14985	COG3100	YcgL domain-containing protein
KBQ49_RS14990	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KBQ49_RS15000	COG0463	Glycosyl transferase, family 2
KBQ49_RS15035	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
KBQ49_RS15050	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KBQ49_RS15075	COG1294	oxidase, subunit
KBQ49_RS15080	COG1271	oxidase subunit
KBQ49_RS15100	COG0408	coproporphyrinogen oxidase activity
KBQ49_RS15110	COG2323	membrane
KBQ49_RS15115	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KBQ49_RS15115	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KBQ49_RS15135	COG0589	response to stress
KBQ49_RS15160	COG0210	DNA helicase
KBQ49_RS15210	COG0463	Glycosyl transferase, family 2
KBQ49_RS15220	COG1475	DNA binding
KBQ49_RS15225	COG1192	Involved in chromosome partitioning
KBQ49_RS15230	COG0357	Ribosomal RNA small subunit methyltransferase G
KBQ49_RS15235	COG2091	lysine biosynthetic process via aminoadipic acid
KBQ49_RS15260	COG0477	Major facilitator Superfamily
KBQ49_RS15280	COG1971	Probably functions as a manganese efflux pump
KBQ49_RS15285	COG2205	protein histidine kinase activity
KBQ49_RS15295	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KBQ49_RS15300	COG3459	Glycosyltransferase 36 associated
KBQ49_RS15305	COG2211	Major facilitator Superfamily
KBQ49_RS15310	COG3265	gluconokinase activity
KBQ49_RS15325	COG2911	Protein conserved in bacteria
KBQ49_RS15330	COG0729	surface antigen
KBQ49_RS15350	COG3132	Protein of unknown function, DUF480
KBQ49_RS15380	COG0284	orotidine-5'-phosphate decarboxylase activity
KBQ49_RS15395	COG1609	Transcriptional regulator
KBQ49_RS15405	COG2937	Belongs to the GPAT DAPAT family
KBQ49_RS15430	COG2211	Major facilitator Superfamily
KBQ49_RS15445	COG3693	PFAM glycoside hydrolase, family 10
KBQ49_RS15450	COG1904	glucuronate isomerase
KBQ49_RS15470	COG3046	protein related to deoxyribodipyrimidine photolyase
KBQ49_RS15485	COG0246	Mannitol dehydrogenase
KBQ49_RS15490	COG1472	Belongs to the glycosyl hydrolase 3 family
KBQ49_RS15500	COG4948	Mandelate Racemase Muconate Lactonizing
KBQ49_RS15510	COG3661	Belongs to the glycosyl hydrolase 67 family
KBQ49_RS15520	COG2115	Belongs to the xylose isomerase family
KBQ49_RS15525	COG0037	tRNA processing
KBQ49_RS15545	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
KBQ49_RS15555	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
KBQ49_RS15565	COG0805	protein transport
KBQ49_RS15575	COG0518	GMP synthase (glutamine-hydrolyzing) activity
KBQ49_RS15575	COG0519	Catalyzes the synthesis of GMP from XMP
KBQ49_RS15580	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
KBQ49_RS15605	COG1435	thymidine kinase activity
KBQ49_RS15615	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
KBQ49_RS15630	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
KBQ49_RS15645	COG1119	ATPase activity
KBQ49_RS15660	COG0706	membrane insertase activity
KBQ49_RS15665	COG0594	ribonuclease P activity
KBQ49_RS15680	COG0592	DNA-directed DNA polymerase activity
KBQ49_RS15685	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
KBQ49_RS15690	COG0187	DNA topoisomerase II activity
KBQ49_RS15695	COG1266	CAAX protease self-immunity
KBQ49_RS15700	COG0501	Belongs to the peptidase M48B family
KBQ49_RS15740	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KBQ49_RS15755	COG1280	lysine exporter protein (LysE YggA)
KBQ49_RS15770	COG4772	TonB-dependent receptor
KBQ49_RS15780	COG3284	Transcriptional regulator
KBQ49_RS15785	COG1012	belongs to the aldehyde dehydrogenase family
KBQ49_RS15820	COG1304	FMN binding
KBQ49_RS15825	COG2186	Transcriptional regulator
KBQ49_RS15945	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
KBQ49_RS15965	COG4771	TonB-dependent receptor
KBQ49_RS16010	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
KBQ49_RS16025	COG3507	Belongs to the glycosyl hydrolase 43 family
KBQ49_RS16030	COG1609	Transcriptional regulator
KBQ49_RS16040	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
KBQ49_RS16045	COG1028	Short-chain dehydrogenase reductase Sdr
KBQ49_RS16060	COG3186	Phenylalanine-4-hydroxylase
KBQ49_RS16065	COG1522	sequence-specific DNA binding
KBQ49_RS16105	COG1752	Esterase of the alpha-beta hydrolase superfamily
KBQ49_RS16120	COG0671	phosphoesterase, PA-phosphatase related
KBQ49_RS16135	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
KBQ49_RS16170	COG1929	Belongs to the glycerate kinase type-1 family
KBQ49_RS16185	COG4566	intracellular signal transduction
KBQ49_RS16210	COG1322	Protein conserved in bacteria
KBQ49_RS16215	COG0386	Belongs to the glutathione peroxidase family
KBQ49_RS16220	COG2853	Lipoprotein
KBQ49_RS16235	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
KBQ49_RS16240	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
KBQ49_RS16245	COG1127	ABC transporter
KBQ49_RS16250	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
KBQ49_RS16255	COG1074	ATP-dependent DNA helicase activity
KBQ49_RS16260	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
KBQ49_RS16280	COG0537	adenosine 5'-monophosphoramidase activity
KBQ49_RS16305	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
KBQ49_RS16360	COG0477	Major facilitator Superfamily
KBQ49_RS16365	COG0302	gtp cyclohydrolase
KBQ49_RS16390	COG0730	response to heat
KBQ49_RS16405	COG2951	lytic endotransglycosylase activity
KBQ49_RS16465	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
KBQ49_RS16470	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
KBQ49_RS16475	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
KBQ49_RS16480	COG0493	'glutamate synthase
KBQ49_RS16485	COG0067	glutamate synthase
KBQ49_RS16485	COG0070	glutamate synthase
KBQ49_RS16485	COG0069	glutamate synthase activity
KBQ49_RS16530	COG1205	dead DEAH box helicase
KBQ49_RS16530	COG1111	helicase
KBQ49_RS16560	COG2271	Major facilitator Superfamily
KBQ49_RS16600	COG1192	Involved in chromosome partitioning
KBQ49_RS16605	COG2062	phosphohistidine phosphatase, SixA
KBQ49_RS16615	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KBQ49_RS16620	COG2050	protein possibly involved in aromatic compounds catabolism
KBQ49_RS16630	COG2267	carboxylic ester hydrolase activity
KBQ49_RS16640	COG1881	PFAM PEBP family protein
KBQ49_RS16645	COG1968	undecaprenyl-diphosphatase activity
KBQ49_RS16650	COG0174	glutamine synthetase
KBQ49_RS16655	COG0347	Belongs to the P(II) protein family
KBQ49_RS16660	COG0004	ammonium transporteR
KBQ49_RS16665	COG3852	Histidine kinase
KBQ49_RS16670	COG2204	response regulator
KBQ49_RS16675	COG2032	superoxide dismutase activity
KBQ49_RS16680	COG2032	superoxide dismutase activity
KBQ49_RS16690	COG0183	Belongs to the thiolase family
KBQ49_RS16730	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
KBQ49_RS16735	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
KBQ49_RS16745	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
KBQ49_RS16755	COG0612	Peptidase, M16
KBQ49_RS16765	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KBQ49_RS16770	COG3177	Filamentation induced by cAMP protein fic
KBQ49_RS16785	COG0596	Alpha beta hydrolase
KBQ49_RS16795	COG0727	PFAM Uncharacterised protein family (UPF0153)
KBQ49_RS16800	COG0318	PFAM AMP-dependent synthetase and ligase
KBQ49_RS16815	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KBQ49_RS16825	COG1181	Belongs to the D-alanine--D-alanine ligase family
KBQ49_RS16840	COG4232	protein-disulfide reductase activity
KBQ49_RS16845	COG0564	pseudouridine synthase activity
KBQ49_RS16865	COG0339	signal peptide processing
KBQ49_RS16885	COG0583	DNA-binding transcription factor activity
KBQ49_RS16890	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
KBQ49_RS16895	COG2224	Isocitrate lyase
KBQ49_RS16930	COG0659	secondary active sulfate transmembrane transporter activity
KBQ49_RS16960	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
KBQ49_RS16965	COG2130	NADP-dependent
KBQ49_RS16980	COG1187	pseudouridine synthase activity
KBQ49_RS16990	COG1643	Atp-dependent helicase
KBQ49_RS16995	COG0084	hydrolase, TatD family'
KBQ49_RS17075	COG0842	Transport permease protein
KBQ49_RS17080	COG1131	(ABC) transporter
KBQ49_RS17085	COG0633	Ferredoxin
KBQ49_RS17085	COG0543	2 iron, 2 sulfur cluster binding
KBQ49_RS17095	COG1476	TRANSCRIPTIONal
KBQ49_RS17105	COG4555	ABC transporter
KBQ49_RS17200	COG1199	ATP-dependent helicase activity
KBQ49_RS17265	COG0628	permease
KBQ49_RS17275	COG2133	pyrroloquinoline quinone binding
KBQ49_RS17315	COG5463	Belongs to the UPF0441 family
KBQ49_RS17320	COG0754	glutathionylspermidine amidase activity
KBQ49_RS17330	COG0714	Associated with various cellular activities
KBQ49_RS17365	COG1522	sequence-specific DNA binding
KBQ49_RS17380	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
KBQ49_RS17395	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KBQ49_RS17400	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KBQ49_RS17410	COG5001	Diguanylate cyclase
KBQ49_RS17410	COG4251	negative regulation of phosphorylation
KBQ49_RS17410	COG3706	GGDEF domain
KBQ49_RS17410	COG2203	Gaf domain
KBQ49_RS17425	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
KBQ49_RS17460	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
KBQ49_RS17465	COG1040	competence protein
KBQ49_RS17470	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KBQ49_RS17500	COG0606	chelatase, subunit chli
KBQ49_RS17505	COG2960	long-chain fatty acid transporting porin activity
KBQ49_RS17525	COG1166	arginine decarboxylase activity
KBQ49_RS17530	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KBQ49_RS17535	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KBQ49_RS17540	COG1819	glycosyl
KBQ49_RS17545	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
KBQ49_RS17545	COG2755	lipolytic protein G-D-S-L family
KBQ49_RS17550	COG0583	DNA-binding transcription factor activity
KBQ49_RS17570	COG4221	oxidoreductase activity
KBQ49_RS17590	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
KBQ49_RS17610	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
KBQ49_RS17620	COG2814	Major facilitator Superfamily
KBQ49_RS17630	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
KBQ49_RS17635	COG0739	heme binding
KBQ49_RS17640	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
KBQ49_RS17670	COG1064	alcohol dehydrogenase
KBQ49_RS17685	COG4942	peptidase
KBQ49_RS17690	COG0793	Belongs to the peptidase S41A family
KBQ49_RS17725	COG0531	amino acid
KBQ49_RS17730	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
KBQ49_RS17730	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
KBQ49_RS17735	COG1486	melibiose metabolic process
KBQ49_RS17755	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
KBQ49_RS17755	COG1565	acr, cog1565
KBQ49_RS17760	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
KBQ49_RS17765	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
KBQ49_RS17795	COG0109	protoheme IX farnesyltransferase activity
KBQ49_RS17815	COG0358	DNA primase activity
KBQ49_RS17820	COG1295	ribonuclease BN
KBQ49_RS17840	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
KBQ49_RS17860	COG2308	Evidence 4 Homologs of previously reported genes of
KBQ49_RS17875	COG2133	pyrroloquinoline quinone binding
KBQ49_RS17895	COG0531	amino acid
KBQ49_RS17905	COG4948	Mandelate Racemase Muconate Lactonizing
KBQ49_RS17915	COG4771	TonB-dependent receptor
KBQ49_RS17945	COG3409	Peptidoglycan-binding domain 1 protein
KBQ49_RS17945	COG3501	Rhs element vgr protein
KBQ49_RS17985	COG5383	Protein conserved in bacteria
KBQ49_RS17995	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KBQ49_RS18000	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KBQ49_RS18005	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KBQ49_RS18020	COG1652	LysM domain
KBQ49_RS18030	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
KBQ49_RS18035	COG1518	maintenance of DNA repeat elements
KBQ49_RS18075	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
KBQ49_RS18085	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
KBQ49_RS18095	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
KBQ49_RS18100	COG3118	belongs to the thioredoxin family
KBQ49_RS18110	COG2884	Cell division ATP-binding protein ftsE
KBQ49_RS18115	COG2177	Part of the ABC transporter FtsEX involved in
KBQ49_RS18120	COG2201	protein-glutamate methylesterase activity
KBQ49_RS18125	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
KBQ49_RS18130	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KBQ49_RS18140	COG1252	NADH dehydrogenase
KBQ49_RS18150	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
KBQ49_RS18160	COG0534	Mate efflux family protein
KBQ49_RS18165	COG0616	signal peptide processing
KBQ49_RS18175	COG1028	Short-chain dehydrogenase reductase Sdr
KBQ49_RS18190	COG0009	L-threonylcarbamoyladenylate synthase
KBQ49_RS18195	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
KBQ49_RS18195	COG1754	DNA topoisomerase type I activity
KBQ49_RS18200	COG1714	RDD family
KBQ49_RS18215	COG0758	DNA mediated transformation
KBQ49_RS18220	COG1652	LysM domain
KBQ49_RS18225	COG0242	peptide deformylase activity
KBQ49_RS18230	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
KBQ49_RS18235	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
KBQ49_RS18235	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KBQ49_RS18240	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
KBQ49_RS18250	COG3307	-O-antigen
KBQ49_RS18275	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
KBQ49_RS18290	COG1490	D-aminoacyl-tRNA deacylase activity
KBQ49_RS18295	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KBQ49_RS18330	COG1609	Transcriptional regulator
KBQ49_RS18340	COG0366	Alpha amylase catalytic
KBQ49_RS18345	COG0366	Alpha amylase catalytic
KBQ49_RS18395	COG3704	protein secretion by the type IV secretion system
KBQ49_RS18490	COG1309	transcriptional regulator
KBQ49_RS18535	COG0840	transmembrane signaling receptor activity
KBQ49_RS18555	COG3546	catalase activity
KBQ49_RS18560	COG3685	Protein conserved in bacteria
KBQ49_RS18565	COG3685	Protein conserved in bacteria
KBQ49_RS18570	COG1028	Short-chain dehydrogenase reductase Sdr
KBQ49_RS18580	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
KBQ49_RS18595	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
KBQ49_RS18610	COG0028	Belongs to the TPP enzyme family
KBQ49_RS18615	COG4191	Histidine kinase
KBQ49_RS18620	COG2204	response regulator
KBQ49_RS18645	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
KBQ49_RS18660	COG3645	SOS response
KBQ49_RS18690	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KBQ49_RS18690	COG1116	anion transmembrane transporter activity
KBQ49_RS18695	COG2223	nitrite transmembrane transporter activity
KBQ49_RS18700	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KBQ49_RS18705	COG2146	nitrite reductase [NAD(P)H] activity
KBQ49_RS18710	COG0243	molybdopterin cofactor binding
KBQ49_RS18735	COG1640	4-alpha-glucanotransferase
KBQ49_RS18740	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
KBQ49_RS18760	COG0745	RESPONSE REGULATOR receiver
KBQ49_RS18785	COG0181	hydroxymethylbilane synthase activity
KBQ49_RS18810	COG1733	regulation of RNA biosynthetic process
KBQ49_RS18825	COG1505	serine-type exopeptidase activity
KBQ49_RS18830	COG0436	Aminotransferase
KBQ49_RS18840	COG2832	Protein of unknown function (DUF454)
KBQ49_RS18850	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
KBQ49_RS18895	COG2226	methyltransferase
KBQ49_RS18905	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
KBQ49_RS18910	COG0308	aminopeptidase N
KBQ49_RS18915	COG0508	dehydrogenase complex catalyzes the overall conversion of
KBQ49_RS18915	COG0596	Alpha beta hydrolase
KBQ49_RS18940	COG2010	Cytochrome c
KBQ49_RS18950	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
KBQ49_RS18960	COG3284	Transcriptional regulator
KBQ49_RS18965	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KBQ49_RS18970	COG1077	Cell shape determining protein MreB Mrl
KBQ49_RS18985	COG0768	penicillin binding
KBQ49_RS18990	COG0772	Belongs to the SEDS family
KBQ49_RS19005	COG2951	lytic endotransglycosylase activity
KBQ49_RS19015	COG1686	Belongs to the peptidase S11 family
KBQ49_RS19080	COG0321	lipoyl(octanoyl) transferase activity
KBQ49_RS19085	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
KBQ49_RS19115	COG1051	belongs to the nudix hydrolase family
KBQ49_RS19115	COG1056	cytidyltransferase-related domain
KBQ49_RS19135	COG1090	epimerase
KBQ49_RS19145	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
KBQ49_RS19150	COG0673	inositol 2-dehydrogenase activity
KBQ49_RS19155	COG2823	Periplasmic or secreted lipoprotein
KBQ49_RS19165	COG2202	Pas domain
KBQ49_RS19165	COG2205	protein histidine kinase activity
KBQ49_RS19170	COG0784	Response regulator, receiver
KBQ49_RS19175	COG4191	Histidine kinase
KBQ49_RS19185	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
KBQ49_RS19190	COG1028	Short-chain dehydrogenase reductase Sdr
KBQ49_RS19205	COG4305	rare lipoprotein A
KBQ49_RS19230	COG3250	beta-galactosidase activity
KBQ49_RS19245	COG2188	Transcriptional regulator
KBQ49_RS19250	COG0738	Major facilitator superfamily
KBQ49_RS19255	COG1609	Transcriptional regulator
KBQ49_RS19260	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
KBQ49_RS19265	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
KBQ49_RS19275	COG0617	tRNA 3'-terminal CCA addition
KBQ49_RS19295	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
KBQ49_RS19345	COG2205	protein histidine kinase activity
KBQ49_RS19360	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
KBQ49_RS19365	COG3791	Glutathione-dependent formaldehyde-activating
KBQ49_RS19375	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KBQ49_RS19420	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
KBQ49_RS19440	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
KBQ49_RS19470	COG1162	GTPase activity
KBQ49_RS19495	COG2211	Major facilitator Superfamily
KBQ49_RS19505	COG1028	Short-chain dehydrogenase reductase Sdr
KBQ49_RS19510	COG2851	Citrate transporter
KBQ49_RS19545	COG4191	Histidine kinase
KBQ49_RS19555	COG1301	dicarboxylic acid transport
KBQ49_RS19560	COG0280	phosphate acetyltransferase
KBQ49_RS19560	COG0281	malic enzyme
KBQ49_RS19630	COG1560	Kdo2-lipid A biosynthetic process
KBQ49_RS19635	COG1519	Transferase
KBQ49_RS19640	COG1538	Outer membrane efflux protein
KBQ49_RS19645	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
KBQ49_RS19655	COG3706	GGDEF domain
KBQ49_RS19660	COG0473	3-isopropylmalate dehydrogenase activity
KBQ49_RS19665	COG0066	3-isopropylmalate dehydratase activity
KBQ49_RS19685	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
KBQ49_RS19705	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
KBQ49_RS19735	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
KBQ49_RS19770	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
KBQ49_RS19780	COG0671	phosphoesterase, PA-phosphatase related
KBQ49_RS19795	COG1940	carbohydrate kinase activity
KBQ49_RS19805	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KBQ49_RS19815	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
KBQ49_RS19830	COG1773	rubredoxin
KBQ49_RS19845	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
KBQ49_RS19855	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
KBQ49_RS19880	COG3079	Belongs to the UPF0149 family
KBQ49_RS19885	COG0006	proline dipeptidase activity
KBQ49_RS19890	COG0006	proline dipeptidase activity
KBQ49_RS19905	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KBQ49_RS19925	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KBQ49_RS19930	COG0667	Aldo Keto reductase
KBQ49_RS19940	COG4771	TonB-dependent receptor
KBQ49_RS19960	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
KBQ49_RS19965	COG4181	ATPase activity
KBQ49_RS19980	COG0642	Histidine kinase
KBQ49_RS19990	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
KBQ49_RS19995	COG0861	Integral membrane protein TerC family
KBQ49_RS20000	COG1704	LemA family
KBQ49_RS20035	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
KBQ49_RS20040	COG2967	ApaG domain
KBQ49_RS20045	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
KBQ49_RS20050	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
KBQ49_RS20055	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KBQ49_RS20070	COG2096	Adenosyltransferase
KBQ49_RS20080	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KBQ49_RS20125	COG0697	spore germination
KBQ49_RS20130	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KBQ49_RS20160	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
KBQ49_RS20175	COG0583	DNA-binding transcription factor activity
KBQ49_RS20180	COG3634	alkyl hydroperoxide reductase activity
KBQ49_RS20230	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
KBQ49_RS20365	COG4962	Type ii secretion system protein e
KBQ49_RS20380	COG3451	type IV secretory pathway VirB4
KBQ49_RS20395	COG3846	protein secretion by the type IV secretion system