locus-tag	class	description
ISN31_RS00040	COG0640	Transcriptional regulator
ISN31_RS00070	COG3047	cAMP biosynthetic process
ISN31_RS00075	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ISN31_RS00125	COG3588	fructose-bisphosphate aldolase
ISN31_RS00165	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ISN31_RS00200	COG1393	Belongs to the ArsC family
ISN31_RS00230	COG0175	sulfate reduction
ISN31_RS00235	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ISN31_RS00240	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ISN31_RS00250	COG2895	sulfate adenylyltransferase (ATP) activity
ISN31_RS00250	COG0529	Catalyzes the synthesis of activated sulfate
ISN31_RS00255	COG0840	transmembrane signaling receptor activity
ISN31_RS00285	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ISN31_RS00300	COG1609	Transcriptional regulator
ISN31_RS00320	COG0179	Fumarylacetoacetate (FAA) hydrolase
ISN31_RS00335	COG0471	metal ion transport
ISN31_RS00335	COG3273	potassium ion transport
ISN31_RS00345	COG2022	thiamine diphosphate biosynthetic process
ISN31_RS00365	COG0174	glutamine synthetase
ISN31_RS00370	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
ISN31_RS00380	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
ISN31_RS00395	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ISN31_RS00420	COG3511	phospholipase C
ISN31_RS00430	COG0189	ligase activity
ISN31_RS00440	COG0745	RESPONSE REGULATOR receiver
ISN31_RS00460	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
ISN31_RS00485	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ISN31_RS00525	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ISN31_RS00525	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ISN31_RS00535	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ISN31_RS00550	COG1174	glycine betaine transport
ISN31_RS00555	COG1125	glycine betaine transport
ISN31_RS00565	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ISN31_RS00570	COG0564	pseudouridine synthase activity
ISN31_RS00595	COG3387	PFAM Glycoside hydrolase 15-related
ISN31_RS00620	COG0454	-acetyltransferase
ISN31_RS00645	COG0542	response to heat
ISN31_RS00670	COG0019	diaminopimelate decarboxylase activity
ISN31_RS00675	COG4264	IucA IucC family
ISN31_RS00680	COG2814	Major facilitator Superfamily
ISN31_RS00685	COG4264	IucA IucC family
ISN31_RS00695	COG4772	TonB-dependent receptor
ISN31_RS00705	COG4651	solute:proton antiporter activity
ISN31_RS00705	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ISN31_RS00795	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ISN31_RS00795	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ISN31_RS00820	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
ISN31_RS00860	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ISN31_RS00865	COG1404	Belongs to the peptidase S8 family
ISN31_RS00900	COG1295	ribonuclease BN
ISN31_RS00905	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ISN31_RS00925	COG0521	Mo-molybdopterin cofactor biosynthetic process
ISN31_RS01035	COG3537	Alpha-1,2-mannosidase
ISN31_RS01055	COG1472	Belongs to the glycosyl hydrolase 3 family
ISN31_RS01065	COG3525	Glycosyl hydrolase, family 20, catalytic domain
ISN31_RS01070	COG3858	chitin binding
ISN31_RS01070	COG1388	LysM domain
ISN31_RS01085	COG0837	glucose binding
ISN31_RS01095	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ISN31_RS01105	COG0494	nUDIX hydrolase
ISN31_RS01110	COG1218	3'(2'),5'-bisphosphate nucleotidase
ISN31_RS01115	COG3956	TIGRFAM MazG family protein
ISN31_RS01120	COG1742	UPF0060 membrane protein
ISN31_RS01125	COG0330	HflC and HflK could
ISN31_RS01185	COG2124	cytochrome p450
ISN31_RS01190	COG2124	cytochrome p450
ISN31_RS01195	COG1141	Ferredoxin
ISN31_RS01200	COG1028	Short-chain dehydrogenase reductase Sdr
ISN31_RS01205	COG2124	cytochrome p450
ISN31_RS01210	COG0142	geranyltranstransferase activity
ISN31_RS01215	COG1657	PFAM Prenyltransferase squalene oxidase
ISN31_RS01225	COG1304	FMN binding
ISN31_RS01245	COG4206	TonB-dependent receptor
ISN31_RS01255	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
ISN31_RS01260	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ISN31_RS01265	COG0463	Glycosyl transferase, family 2
ISN31_RS01270	COG0517	IMP dehydrogenase activity
ISN31_RS01275	COG2982	Protein involved in outer membrane biogenesis
ISN31_RS01280	COG1272	protein, Hemolysin III
ISN31_RS01285	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
ISN31_RS01295	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ISN31_RS01300	COG0626	cystathionine gamma-synthase activity
ISN31_RS01305	COG0460	homoserine dehydrogenase
ISN31_RS01305	COG0527	aspartate kinase activity
ISN31_RS01310	COG2267	carboxylic ester hydrolase activity
ISN31_RS01320	COG1760	l-serine dehydratase
ISN31_RS01335	COG3038	cytochrome b561
ISN31_RS01355	COG2814	Major facilitator Superfamily
ISN31_RS01360	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ISN31_RS01370	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISN31_RS01375	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ISN31_RS01390	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ISN31_RS01450	COG0519	Catalyzes the synthesis of GMP from XMP
ISN31_RS01465	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ISN31_RS01485	COG0840	transmembrane signaling receptor activity
ISN31_RS01495	COG1113	amino acid transport
ISN31_RS01515	COG2239	Acts as a magnesium transporter
ISN31_RS01520	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ISN31_RS01525	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISN31_RS01535	COG1660	Displays ATPase and GTPase activities
ISN31_RS01545	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISN31_RS01560	COG1137	ATPase activity
ISN31_RS01575	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
ISN31_RS01620	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ISN31_RS01645	COG0628	permease
ISN31_RS01655	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
ISN31_RS01660	COG3178	'Phosphotransferase
ISN31_RS01675	COG1555	photosystem II stabilization
ISN31_RS01700	COG1477	protein flavinylation
ISN31_RS01725	COG4774	siderophore transport
ISN31_RS01730	COG2146	nitrite reductase [NAD(P)H] activity
ISN31_RS01740	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ISN31_RS01745	COG0719	Fe-S assembly protein
ISN31_RS01750	COG0396	ATPase activity
ISN31_RS01755	COG0719	Fe-S assembly protein
ISN31_RS01770	COG0693	protein deglycase activity
ISN31_RS01785	COG0739	heme binding
ISN31_RS01800	COG1764	response to oxidative stress
ISN31_RS01810	COG0384	phenazine biosynthesis protein PhzF
ISN31_RS01815	COG0527	aspartate kinase activity
ISN31_RS01840	COG0142	geranyltranstransferase activity
ISN31_RS01845	COG0629	single-stranded DNA binding
ISN31_RS01850	COG3550	peptidyl-serine autophosphorylation
ISN31_RS01865	COG3104	oligopeptide transport
ISN31_RS01870	COG1297	OPT oligopeptide transporter protein
ISN31_RS01875	COG0823	Involved in the tonB-independent uptake of proteins
ISN31_RS01875	COG1506	peptidase
ISN31_RS01895	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ISN31_RS01900	COG2879	small protein
ISN31_RS01905	COG1966	Carbon starvation protein
ISN31_RS01925	COG0588	phosphoglycerate mutase activity
ISN31_RS01940	COG2211	Major facilitator Superfamily
ISN31_RS01970	COG2203	Gaf domain
ISN31_RS01970	COG3706	GGDEF domain
ISN31_RS01970	COG4251	negative regulation of phosphorylation
ISN31_RS01970	COG5001	Diguanylate cyclase
ISN31_RS01975	COG0835	chemotaxis
ISN31_RS01980	COG0840	transmembrane signaling receptor activity
ISN31_RS01985	COG0840	transmembrane signaling receptor activity
ISN31_RS01990	COG0840	transmembrane signaling receptor activity
ISN31_RS01995	COG2198	Histidine kinase
ISN31_RS01995	COG0643	Histidine kinase
ISN31_RS02005	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ISN31_RS02025	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
ISN31_RS02035	COG2205	protein histidine kinase activity
ISN31_RS02065	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ISN31_RS02070	COG0735	belongs to the Fur family
ISN31_RS02105	COG1529	Aldehyde oxidase and xanthine dehydrogenase
ISN31_RS02110	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
ISN31_RS02115	COG2080	2 iron, 2 sulfur cluster binding
ISN31_RS02220	COG1187	pseudouridine synthase activity
ISN31_RS02245	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ISN31_RS02265	COG1132	(ABC) transporter
ISN31_RS02285	COG0583	DNA-binding transcription factor activity
ISN31_RS02325	COG1981	membrane
ISN31_RS02350	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ISN31_RS02355	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ISN31_RS02365	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ISN31_RS02370	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ISN31_RS02375	COG0750	zinc metalloprotease
ISN31_RS02380	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
ISN31_RS02385	COG0575	Belongs to the CDS family
ISN31_RS02390	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ISN31_RS02400	COG0528	UMP kinase activity
ISN31_RS02410	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ISN31_RS02450	COG0024	Methionine aminopeptidase
ISN31_RS02465	COG1393	Belongs to the ArsC family
ISN31_RS02470	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ISN31_RS02480	COG0367	asparagine synthase
ISN31_RS02515	COG1566	PFAM secretion protein HlyD family protein
ISN31_RS02520	COG2814	Major facilitator Superfamily
ISN31_RS02555	COG0557	exoribonuclease II activity
ISN31_RS02565	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ISN31_RS02575	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ISN31_RS02595	COG0704	Plays a role in the regulation of phosphate uptake
ISN31_RS02605	COG0581	inorganic phosphate transmembrane transporter activity
ISN31_RS02615	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ISN31_RS02620	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ISN31_RS02640	COG0659	secondary active sulfate transmembrane transporter activity
ISN31_RS02645	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ISN31_RS02655	COG1024	Enoyl-CoA hydratase
ISN31_RS02715	COG0784	Response regulator, receiver
ISN31_RS02715	COG2205	protein histidine kinase activity
ISN31_RS02715	COG5002	protein histidine kinase activity
ISN31_RS02720	COG2733	membrane
ISN31_RS02740	COG0686	Belongs to the AlaDH PNT family
ISN31_RS02745	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ISN31_RS02750	COG1396	sequence-specific DNA binding
ISN31_RS02750	COG1917	Cupin 2, conserved barrel domain protein
ISN31_RS02755	COG1012	belongs to the aldehyde dehydrogenase family
ISN31_RS02775	COG2223	nitrite transmembrane transporter activity
ISN31_RS02785	COG0243	molybdopterin cofactor binding
ISN31_RS02805	COG0477	Major facilitator Superfamily
ISN31_RS02815	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ISN31_RS02820	COG0174	glutamine synthetase
ISN31_RS02825	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
ISN31_RS02830	COG0174	glutamine synthetase
ISN31_RS02840	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
ISN31_RS02865	COG3842	ATPase activity
ISN31_RS02870	COG1176	ABC-type spermidine putrescine transport system, permease component I
ISN31_RS02875	COG1177	transmembrane transport
ISN31_RS02885	COG1012	belongs to the aldehyde dehydrogenase family
ISN31_RS02900	COG4535	Mg2 and Co2 transporter CorC
ISN31_RS02915	COG1702	phosphate starvation-inducible protein PhoH
ISN31_RS02930	COG0741	lytic transglycosylase activity
ISN31_RS02935	COG0723	plastoquinol--plastocyanin reductase activity
ISN31_RS02940	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ISN31_RS02950	COG2857	Cytochrome c1
ISN31_RS02955	COG0625	glutathione transferase activity
ISN31_RS02960	COG2969	positive regulation of protein catabolic process
ISN31_RS03000	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
ISN31_RS03005	COG1028	Short-chain dehydrogenase reductase Sdr
ISN31_RS03010	COG2095	MarC family integral membrane protein
ISN31_RS03020	COG1611	Belongs to the LOG family
ISN31_RS03025	COG3275	phosphorelay sensor kinase activity
ISN31_RS03070	COG0556	nucleotide-excision repair
ISN31_RS03105	COG2948	multi-organism process
ISN31_RS03205	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
ISN31_RS03215	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ISN31_RS03220	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ISN31_RS03405	COG0305	Participates in initiation and elongation during chromosome replication
ISN31_RS03420	COG0270	DNA (cytosine-5-)-methyltransferase activity
ISN31_RS03480	COG3728	DNA packaging
ISN31_RS03480	COG5484	DNA packaging
ISN31_RS03560	COG1196	nuclear chromosome segregation
ISN31_RS03645	COG0438	transferase activity, transferring glycosyl groups
ISN31_RS03650	COG0438	transferase activity, transferring glycosyl groups
ISN31_RS03660	COG0438	transferase activity, transferring glycosyl groups
ISN31_RS03680	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ISN31_RS03690	COG1960	acyl-CoA dehydrogenase activity
ISN31_RS03725	COG1570	exodeoxyribonuclease VII activity
ISN31_RS03730	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ISN31_RS03735	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ISN31_RS03735	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
ISN31_RS03740	COG0802	atpase or kinase
ISN31_RS03745	COG0860	N-Acetylmuramoyl-L-alanine amidase
ISN31_RS03750	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
ISN31_RS03770	COG1028	Short-chain dehydrogenase reductase Sdr
ISN31_RS03790	COG2081	HI0933 family
ISN31_RS03795	COG4681	YaeQ
ISN31_RS03800	COG0564	pseudouridine synthase activity
ISN31_RS03810	COG0625	glutathione transferase activity
ISN31_RS03815	COG0657	acetylesterase activity
ISN31_RS03820	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
ISN31_RS03845	COG0513	Belongs to the DEAD box helicase family
ISN31_RS03850	COG0488	(ABC) transporter
ISN31_RS03865	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ISN31_RS03875	COG1472	Belongs to the glycosyl hydrolase 3 family
ISN31_RS03915	COG1846	Transcriptional regulator
ISN31_RS03930	COG0386	Belongs to the glutathione peroxidase family
ISN31_RS04005	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
ISN31_RS04010	COG0084	hydrolase, TatD family'
ISN31_RS04025	COG1960	acyl-CoA dehydrogenase activity
ISN31_RS04035	COG0305	Participates in initiation and elongation during chromosome replication
ISN31_RS04040	COG0415	Belongs to the DNA photolyase family
ISN31_RS04055	COG0583	DNA-binding transcription factor activity
ISN31_RS04070	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISN31_RS04110	COG1404	Belongs to the peptidase S8 family
ISN31_RS04115	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ISN31_RS04120	COG2867	negative regulation of translational initiation
ISN31_RS04130	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ISN31_RS04135	COG0735	belongs to the Fur family
ISN31_RS04140	COG0497	DNA recombination
ISN31_RS04145	COG1420	regulation of RNA biosynthetic process
ISN31_RS04150	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ISN31_RS04155	COG0443	Heat shock 70 kDa protein
ISN31_RS04160	COG0484	heat shock protein binding
ISN31_RS04165	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
ISN31_RS04170	COG1605	Chorismate mutase
ISN31_RS04170	COG0287	Prephenate dehydrogenase
ISN31_RS04180	COG1132	(ABC) transporter
ISN31_RS04230	COG2850	peptidyl-arginine hydroxylation
ISN31_RS04270	COG1194	a g-specific adenine glycosylase
ISN31_RS04275	COG0552	protein localization to endoplasmic reticulum
ISN31_RS04285	COG3938	Belongs to the proline racemase family
ISN31_RS04290	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ISN31_RS04305	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ISN31_RS04315	COG0006	proline dipeptidase activity
ISN31_RS04330	COG0531	amino acid
ISN31_RS04355	COG4206	TonB-dependent receptor
ISN31_RS04365	COG3507	Belongs to the glycosyl hydrolase 43 family
ISN31_RS04375	COG4771	TonB-dependent receptor
ISN31_RS04400	COG0742	ribosomal rna small subunit methyltransferase
ISN31_RS04415	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ISN31_RS04420	COG0405	Gamma-glutamyltransferase
ISN31_RS04425	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ISN31_RS04430	COG3291	Pkd domain containing protein
ISN31_RS04435	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
ISN31_RS04445	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ISN31_RS04455	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
ISN31_RS04465	COG1862	Preprotein translocase
ISN31_RS04470	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ISN31_RS04495	COG4251	negative regulation of phosphorylation
ISN31_RS04495	COG5001	Diguanylate cyclase
ISN31_RS04495	COG3706	GGDEF domain
ISN31_RS04495	COG2203	Gaf domain
ISN31_RS04500	COG1509	lysine 2,3-aminomutase activity
ISN31_RS04510	COG3548	integral membrane protein
ISN31_RS04515	COG0402	S-adenosylhomocysteine deaminase activity
ISN31_RS04545	COG4677	pectinesterase activity
ISN31_RS04560	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ISN31_RS04590	COG2166	iron-sulfur cluster assembly
ISN31_RS04605	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ISN31_RS04610	COG0137	argininosuccinate synthase activity
ISN31_RS04615	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ISN31_RS04620	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ISN31_RS04630	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ISN31_RS04635	COG0165	Argininosuccinate lyase
ISN31_RS04655	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ISN31_RS04685	COG1501	Belongs to the glycosyl hydrolase 31 family
ISN31_RS04695	COG1070	Carbohydrate kinase
ISN31_RS04700	COG2115	Belongs to the xylose isomerase family
ISN31_RS04705	COG0477	Major facilitator Superfamily
ISN31_RS04710	COG0860	N-Acetylmuramoyl-L-alanine amidase
ISN31_RS04730	COG0617	tRNA 3'-terminal CCA addition
ISN31_RS04740	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ISN31_RS04755	COG0166	Belongs to the GPI family
ISN31_RS04775	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
ISN31_RS04790	COG0671	phosphoesterase, PA-phosphatase related
ISN31_RS04815	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ISN31_RS04820	COG0167	dihydroorotate dehydrogenase activity
ISN31_RS04835	COG1012	belongs to the aldehyde dehydrogenase family
ISN31_RS04850	COG0460	homoserine dehydrogenase
ISN31_RS04850	COG0527	aspartate kinase activity
ISN31_RS04860	COG2951	lytic endotransglycosylase activity
ISN31_RS04870	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ISN31_RS04880	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ISN31_RS04885	COG0124	histidyl-tRNA synthetase
ISN31_RS04895	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
ISN31_RS04900	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ISN31_RS04905	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ISN31_RS04915	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ISN31_RS04930	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ISN31_RS04930	COG0140	phosphoribosyl-ATP diphosphatase activity
ISN31_RS04945	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
ISN31_RS04950	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
ISN31_RS04955	COG0235	Class ii aldolase
ISN31_RS04960	COG0531	amino acid
ISN31_RS04965	COG0531	amino acid
ISN31_RS04980	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ISN31_RS04985	COG0277	FAD linked oxidase domain protein
ISN31_RS05005	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ISN31_RS05020	COG1024	Enoyl-CoA hydratase
ISN31_RS05065	COG1741	Belongs to the pirin family
ISN31_RS05070	COG0583	DNA-binding transcription factor activity
ISN31_RS05090	COG0351	phosphomethylpyrimidine kinase
ISN31_RS05105	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
ISN31_RS05110	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ISN31_RS05120	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ISN31_RS05130	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
ISN31_RS05135	COG3734	2-keto-3-deoxy-galactonokinase
ISN31_RS05150	COG0800	Aldolase
ISN31_RS05185	COG0784	Response regulator, receiver
ISN31_RS05185	COG2205	protein histidine kinase activity
ISN31_RS05185	COG2198	Histidine kinase
ISN31_RS05190	COG1024	Enoyl-CoA hydratase
ISN31_RS05195	COG0318	PFAM AMP-dependent synthetase and ligase
ISN31_RS05225	COG3706	GGDEF domain
ISN31_RS05250	COG0840	transmembrane signaling receptor activity
ISN31_RS05260	COG0840	transmembrane signaling receptor activity
ISN31_RS05270	COG0835	chemotaxis
ISN31_RS05280	COG0840	transmembrane signaling receptor activity
ISN31_RS05290	COG0840	transmembrane signaling receptor activity
ISN31_RS05295	COG0840	transmembrane signaling receptor activity
ISN31_RS05300	COG0840	transmembrane signaling receptor activity
ISN31_RS05310	COG0840	transmembrane signaling receptor activity
ISN31_RS05320	COG0840	transmembrane signaling receptor activity
ISN31_RS05330	COG0840	transmembrane signaling receptor activity
ISN31_RS05335	COG0840	transmembrane signaling receptor activity
ISN31_RS05350	COG0745	RESPONSE REGULATOR receiver
ISN31_RS05365	COG1192	Involved in chromosome partitioning
ISN31_RS05375	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
ISN31_RS05380	COG0643	Histidine kinase
ISN31_RS05380	COG2198	Histidine kinase
ISN31_RS05380	COG0784	Response regulator, receiver
ISN31_RS05385	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
ISN31_RS05430	COG1684	flagellar biosynthetic protein fliR
ISN31_RS05435	COG1987	bacterial-type flagellum assembly
ISN31_RS05445	COG3190	flagellar
ISN31_RS05495	COG1677	Flagellar hook-basal body complex protein FliE
ISN31_RS05540	COG1028	Short-chain dehydrogenase reductase Sdr
ISN31_RS05545	COG1028	Short-chain dehydrogenase reductase Sdr
ISN31_RS05550	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ISN31_RS05570	COG2201	protein-glutamate methylesterase activity
ISN31_RS05575	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
ISN31_RS05580	COG2197	response regulator
ISN31_RS05600	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
ISN31_RS05605	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ISN31_RS05610	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ISN31_RS05615	COG1256	bacterial-type flagellum assembly
ISN31_RS05615	COG1256	bacterial-type flagellum assembly
ISN31_RS05615	COG4786	Flagellar basal body rod
ISN31_RS05615	COG4786	Flagellar basal body rod
ISN31_RS05630	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
ISN31_RS05645	COG1749	Flagellar hook protein flgE
ISN31_RS05655	COG1558	bacterial-type flagellum-dependent cell motility
ISN31_RS05665	COG0835	chemotaxis
ISN31_RS05665	COG0784	Response regulator, receiver
ISN31_RS05725	COG2915	High frequency lysogenization protein hflD homolog
ISN31_RS05730	COG0482	sulfurtransferase activity
ISN31_RS05750	COG0542	response to heat
ISN31_RS05770	COG0492	ferredoxin-NADP+ reductase activity
ISN31_RS05775	COG1674	ftsk spoiiie
ISN31_RS05795	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ISN31_RS05800	COG0038	chloride channel
ISN31_RS05855	COG1595	DNA-templated transcription, initiation
ISN31_RS05875	COG3038	cytochrome b561
ISN31_RS05905	COG2244	polysaccharide biosynthetic process
ISN31_RS05925	COG4106	trans-aconitate 2-methyltransferase activity
ISN31_RS05945	COG0438	transferase activity, transferring glycosyl groups
ISN31_RS05950	COG0438	transferase activity, transferring glycosyl groups
ISN31_RS05970	COG1132	(ABC) transporter
ISN31_RS06005	COG1022	Amp-dependent synthetase and ligase
ISN31_RS06040	COG0512	Glutamine amidotransferase of anthranilate synthase
ISN31_RS06055	COG2801	Transposase and inactivated derivatives
ISN31_RS06080	COG1530	ribonuclease E activity
ISN31_RS06095	COG0428	transporter
ISN31_RS06110	COG0316	Belongs to the HesB IscA family
ISN31_RS06110	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
ISN31_RS06130	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISN31_RS06150	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ISN31_RS06155	COG2957	Belongs to the agmatine deiminase family
ISN31_RS06165	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ISN31_RS06170	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
ISN31_RS06175	COG0539	negative regulation of cytoplasmic translation
ISN31_RS06180	COG0776	regulation of translation
ISN31_RS06190	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
ISN31_RS06195	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ISN31_RS06205	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ISN31_RS06210	COG0183	Belongs to the thiolase family
ISN31_RS06215	COG1024	Enoyl-CoA hydratase
ISN31_RS06215	COG1250	3-hydroxyacyl-CoA dehydrogenase
ISN31_RS06230	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ISN31_RS06240	COG1426	Protein conserved in bacteria
ISN31_RS06250	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ISN31_RS06260	COG0746	molybdenum cofactor guanylyltransferase activity
ISN31_RS06270	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ISN31_RS06275	COG0475	glutathione-regulated potassium exporter activity
ISN31_RS06275	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ISN31_RS06290	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ISN31_RS06300	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ISN31_RS06300	COG0519	Catalyzes the synthesis of GMP from XMP
ISN31_RS06360	COG1501	Belongs to the glycosyl hydrolase 31 family
ISN31_RS06365	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
ISN31_RS06375	COG1914	H( )-stimulated, divalent metal cation uptake system
ISN31_RS06390	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
ISN31_RS06395	COG0668	transmembrane transport
ISN31_RS06405	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
ISN31_RS06420	COG1028	Short-chain dehydrogenase reductase Sdr
ISN31_RS06425	COG1183	phosphatidylcholine synthase activity
ISN31_RS06435	COG3243	poly(R)-hydroxyalkanoic acid synthase
ISN31_RS06465	COG0784	Response regulator, receiver
ISN31_RS06465	COG4191	Histidine kinase
ISN31_RS06470	COG2183	response to ionizing radiation
ISN31_RS06475	COG0784	Response regulator, receiver
ISN31_RS06475	COG2205	protein histidine kinase activity
ISN31_RS06540	COG1649	PFAM Uncharacterised BCR, COG1649
ISN31_RS06550	COG1304	FMN binding
ISN31_RS06560	COG0346	lactoylglutathione lyase activity
ISN31_RS06575	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ISN31_RS06600	COG1024	Enoyl-CoA hydratase
ISN31_RS06605	COG1024	Enoyl-CoA hydratase
ISN31_RS06615	COG1024	Enoyl-CoA hydratase
ISN31_RS06635	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
ISN31_RS06780	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ISN31_RS06790	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ISN31_RS06795	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ISN31_RS06805	COG0505	Belongs to the CarA family
ISN31_RS06815	COG2258	MOSC domain
ISN31_RS06820	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ISN31_RS06850	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ISN31_RS06860	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ISN31_RS06865	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
ISN31_RS06910	COG0464	growth
ISN31_RS06945	COG0494	nUDIX hydrolase
ISN31_RS06955	COG2814	Major facilitator Superfamily
ISN31_RS07005	COG0629	single-stranded DNA binding
ISN31_RS07010	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ISN31_RS07020	COG0270	DNA (cytosine-5-)-methyltransferase activity
ISN31_RS07300	COG0583	DNA-binding transcription factor activity
ISN31_RS07305	COG0582	viral genome integration into host DNA
ISN31_RS07315	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ISN31_RS07330	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ISN31_RS07340	COG1663	tetraacyldisaccharide 4'-kinase activity
ISN31_RS07345	COG1132	(ABC) transporter
ISN31_RS07355	COG0811	peptide transport
ISN31_RS07380	COG4591	ABC-type transport system involved in lipoprotein release permease component
ISN31_RS07390	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
ISN31_RS07405	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
ISN31_RS07410	COG2009	succinate dehydrogenase
ISN31_RS07420	COG0354	folic acid binding
ISN31_RS07425	COG3842	ATPase activity
ISN31_RS07430	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ISN31_RS07445	COG0129	dihydroxy-acid dehydratase activity
ISN31_RS07460	COG0395	ABC-type sugar transport system, permease component
ISN31_RS07495	COG2350	Protein conserved in bacteria
ISN31_RS07500	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
ISN31_RS07505	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
ISN31_RS07510	COG1187	pseudouridine synthase activity
ISN31_RS07535	COG0436	Aminotransferase
ISN31_RS07540	COG4133	protoheme IX ABC transporter activity
ISN31_RS07585	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ISN31_RS07590	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
ISN31_RS07595	COG4988	ABC transporter
ISN31_RS07605	COG1294	oxidase, subunit
ISN31_RS07655	COG2137	regulation of response to DNA damage stimulus
ISN31_RS07660	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ISN31_RS07665	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ISN31_RS07670	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ISN31_RS07675	COG1546	Belongs to the CinA family
ISN31_RS07680	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ISN31_RS07690	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ISN31_RS07695	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ISN31_RS07700	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ISN31_RS07705	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
ISN31_RS07710	COG1534	Rna-binding protein
ISN31_RS07725	COG1238	metal cluster binding
ISN31_RS07735	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
ISN31_RS07750	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ISN31_RS07755	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ISN31_RS07760	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
ISN31_RS07775	COG0504	CTP synthase activity
ISN31_RS07795	COG0306	phosphate transporter
ISN31_RS07805	COG1253	flavin adenine dinucleotide binding
ISN31_RS07820	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ISN31_RS07855	COG0069	glutamate synthase activity
ISN31_RS07860	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
ISN31_RS07870	COG1609	Transcriptional regulator
ISN31_RS07875	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ISN31_RS07875	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISN31_RS07880	COG1105	Belongs to the carbohydrate kinase PfkB family
ISN31_RS07885	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISN31_RS07885	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISN31_RS07915	COG1136	(ABC) transporter
ISN31_RS07915	COG0577	efflux transmembrane transporter activity
ISN31_RS07960	COG0583	DNA-binding transcription factor activity
ISN31_RS07985	COG0077	Prephenate dehydratase
ISN31_RS07985	COG1605	Chorismate mutase
ISN31_RS07990	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
ISN31_RS07995	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ISN31_RS08035	COG4221	oxidoreductase activity
ISN31_RS08050	COG1228	amidohydrolase
ISN31_RS08065	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
ISN31_RS08100	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
ISN31_RS08110	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
ISN31_RS08115	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ISN31_RS08120	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ISN31_RS08155	COG0316	Belongs to the HesB IscA family
ISN31_RS08225	COG0288	reversible hydration of carbon dioxide
ISN31_RS08240	COG3844	kynureninase activity
ISN31_RS08250	COG2925	Exonuclease
ISN31_RS08310	COG2902	Dehydrogenase
ISN31_RS08320	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISN31_RS08325	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ISN31_RS08355	COG1960	acyl-CoA dehydrogenase activity
ISN31_RS08360	COG2226	methyltransferase
ISN31_RS08365	COG0646	methionine synthase
ISN31_RS08365	COG1410	methionine synthase
ISN31_RS08370	COG0646	methionine synthase
ISN31_RS08370	COG1410	methionine synthase
ISN31_RS08380	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
ISN31_RS08380	COG2755	lipolytic protein G-D-S-L family
ISN31_RS08390	COG2900	Belongs to the SlyX family
ISN31_RS08405	COG0386	Belongs to the glutathione peroxidase family
ISN31_RS08415	COG1725	Transcriptional regulator
ISN31_RS08420	COG1131	(ABC) transporter
ISN31_RS08485	COG0835	chemotaxis
ISN31_RS08490	COG0840	transmembrane signaling receptor activity
ISN31_RS08495	COG0840	transmembrane signaling receptor activity
ISN31_RS08510	COG3300	MHYT domain
ISN31_RS08510	COG5001	Diguanylate cyclase
ISN31_RS08520	COG1185	polyribonucleotide nucleotidyltransferase activity
ISN31_RS08545	COG0195	Participates in both transcription termination and antitermination
ISN31_RS08560	COG1007	ATP synthesis coupled electron transport
ISN31_RS08600	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
ISN31_RS08605	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
ISN31_RS08610	COG0649	NAD binding
ISN31_RS08615	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ISN31_RS08625	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ISN31_RS08655	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
ISN31_RS08715	COG2890	protein-(glutamine-N5) methyltransferase activity
ISN31_RS08725	COG0688	phosphatidylethanolamine metabolic process
ISN31_RS08730	COG0741	lytic transglycosylase activity
ISN31_RS08735	COG0433	COG0433 Predicted ATPase
ISN31_RS08740	COG0494	nUDIX hydrolase
ISN31_RS08755	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ISN31_RS08780	COG0717	Belongs to the dCTP deaminase family
ISN31_RS08785	COG0489	protein tyrosine kinase activity
ISN31_RS08795	COG4771	TonB-dependent receptor
ISN31_RS08805	COG4771	TonB-dependent receptor
ISN31_RS08810	COG0457	Tetratricopeptide repeat
ISN31_RS08825	COG3590	peptidase
ISN31_RS08865	COG0697	spore germination
ISN31_RS08885	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ISN31_RS08890	COG2311	Membrane
ISN31_RS08895	COG1047	Peptidyl-prolyl cis-trans
ISN31_RS08900	COG0791	NLP P60 protein
ISN31_RS08905	COG0791	NLP P60 protein
ISN31_RS08920	COG1607	acyl-coa hydrolase
ISN31_RS08930	COG1301	dicarboxylic acid transport
ISN31_RS08935	COG1785	Belongs to the alkaline phosphatase family
ISN31_RS08945	COG0037	tRNA processing
ISN31_RS08950	COG1722	exodeoxyribonuclease VII activity
ISN31_RS08955	COG0142	geranyltranstransferase activity
ISN31_RS08965	COG1858	cytochrome C peroxidase
ISN31_RS08990	COG0515	serine threonine protein kinase
ISN31_RS08990	COG2815	serine threonine protein kinase
ISN31_RS08995	COG0631	protein serine/threonine phosphatase activity
ISN31_RS09090	COG0312	modulator of DNA gyrase
ISN31_RS09100	COG0312	modulator of DNA gyrase
ISN31_RS09120	COG2968	Membrane
ISN31_RS09135	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
ISN31_RS09150	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ISN31_RS09165	COG0495	leucyl-tRNA aminoacylation
ISN31_RS09175	COG3118	belongs to the thioredoxin family
ISN31_RS09190	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
ISN31_RS09200	COG2040	homocysteine
ISN31_RS09205	COG0833	amino acid
ISN31_RS09215	COG0346	lactoylglutathione lyase activity
ISN31_RS09235	COG2878	Part of a membrane complex involved in electron transport
ISN31_RS09250	COG1595	DNA-templated transcription, initiation
ISN31_RS09275	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ISN31_RS09295	COG0251	oxidation-reduction process
ISN31_RS09305	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
ISN31_RS09305	COG0392	lysyltransferase activity
ISN31_RS09335	COG2814	Major facilitator Superfamily
ISN31_RS09340	COG1902	pentaerythritol trinitrate reductase activity
ISN31_RS09345	COG2824	Alkylphosphonate utilization operon protein PhnA
ISN31_RS09350	COG1047	Peptidyl-prolyl cis-trans
ISN31_RS09355	COG1077	Cell shape determining protein MreB Mrl
ISN31_RS09390	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ISN31_RS09400	COG1451	nucleotide metabolic process
ISN31_RS09420	COG2198	Histidine kinase
ISN31_RS09420	COG0784	Response regulator, receiver
ISN31_RS09420	COG2205	protein histidine kinase activity
ISN31_RS09430	COG2186	Transcriptional regulator
ISN31_RS09435	COG3250	beta-galactosidase activity
ISN31_RS09500	COG1703	isobutyryl-CoA mutase activity
ISN31_RS09500	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ISN31_RS09500	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ISN31_RS09530	COG0183	Belongs to the thiolase family
ISN31_RS09540	COG0443	Heat shock 70 kDa protein
ISN31_RS09570	COG1793	dna ligase
ISN31_RS09570	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
ISN31_RS09575	COG1793	dna ligase
ISN31_RS09575	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
ISN31_RS09580	COG1201	RNA secondary structure unwinding
ISN31_RS09590	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ISN31_RS09595	COG1278	Cold shock
ISN31_RS09600	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
ISN31_RS09605	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
ISN31_RS09610	COG1472	Belongs to the glycosyl hydrolase 3 family
ISN31_RS09620	COG2954	triphosphatase activity
ISN31_RS09630	COG0745	RESPONSE REGULATOR receiver
ISN31_RS09635	COG1381	Involved in DNA repair and RecF pathway recombination
ISN31_RS09640	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ISN31_RS09655	COG0681	Belongs to the peptidase S26 family
ISN31_RS09660	COG0481	GTPase activity
ISN31_RS09665	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ISN31_RS09680	COG1024	Enoyl-CoA hydratase
ISN31_RS09680	COG1250	3-hydroxyacyl-CoA dehydrogenase
ISN31_RS09700	COG2855	membrane
ISN31_RS09715	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ISN31_RS09735	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
ISN31_RS09745	COG0534	Mate efflux family protein
ISN31_RS09750	COG0335	large ribosomal subunit rRNA binding
ISN31_RS09755	COG0336	Belongs to the RNA methyltransferase TrmD family
ISN31_RS09760	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ISN31_RS09765	COG0228	four-way junction DNA binding
ISN31_RS09775	COG2070	2-Nitropropane dioxygenase
ISN31_RS09780	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ISN31_RS09805	COG0475	glutathione-regulated potassium exporter activity
ISN31_RS09815	COG0625	glutathione transferase activity
ISN31_RS09820	COG1082	Xylose isomerase domain protein TIM barrel
ISN31_RS09830	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISN31_RS09835	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISN31_RS09840	COG1129	ABC transporter
ISN31_RS09845	COG1879	ABC-type sugar transport system periplasmic component
ISN31_RS09850	COG1012	belongs to the aldehyde dehydrogenase family
ISN31_RS09870	COG0129	dihydroxy-acid dehydratase activity
ISN31_RS09900	COG2207	Transcriptional regulator
ISN31_RS09945	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ISN31_RS09970	COG4794	Type iii secretion
ISN31_RS10000	COG0745	RESPONSE REGULATOR receiver
ISN31_RS10050	COG0156	8-amino-7-oxononanoate synthase activity
ISN31_RS10060	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
ISN31_RS10065	COG1845	cytochrome c oxidase, subunit III
ISN31_RS10070	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ISN31_RS10120	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
ISN31_RS10120	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ISN31_RS10210	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ISN31_RS10225	COG0196	riboflavin kinase activity
ISN31_RS10240	COG0728	peptidoglycan biosynthetic process
ISN31_RS10250	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ISN31_RS10255	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ISN31_RS10260	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ISN31_RS10265	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ISN31_RS10270	COG0824	Thioesterase
ISN31_RS10280	COG1024	Enoyl-CoA hydratase
ISN31_RS10285	COG1946	Acyl-CoA thioesterase
ISN31_RS10365	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ISN31_RS10410	COG1643	Atp-dependent helicase
ISN31_RS10415	COG0783	Belongs to the Dps family
ISN31_RS10420	COG0514	ATP-dependent DNA helicase (RecQ)
ISN31_RS10440	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
ISN31_RS10445	COG0602	queuosine metabolic process
ISN31_RS10455	COG2885	chlorophyll binding
ISN31_RS10470	COG0848	biopolymer transport protein
ISN31_RS10480	COG0824	Thioesterase
ISN31_RS10485	COG2255	four-way junction helicase activity
ISN31_RS10490	COG3158	transport of potassium into the cell
ISN31_RS10495	COG0632	four-way junction helicase activity
ISN31_RS10505	COG0217	transcriptional regulatory protein
ISN31_RS10545	COG3142	Participates in the control of copper homeostasis
ISN31_RS10550	COG1446	asparaginase
ISN31_RS10590	COG2201	protein-glutamate methylesterase activity
ISN31_RS10595	COG0643	Histidine kinase
ISN31_RS10595	COG0784	Response regulator, receiver
ISN31_RS10595	COG2198	Histidine kinase
ISN31_RS10600	COG0840	transmembrane signaling receptor activity
ISN31_RS10605	COG0835	chemotaxis
ISN31_RS10620	COG0189	ligase activity
ISN31_RS10640	COG1199	ATP-dependent helicase activity
ISN31_RS10650	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ISN31_RS10655	COG1216	Glycosyl transferase, family 2
ISN31_RS10680	COG4585	Histidine kinase
ISN31_RS10690	COG0850	regulation of cytokinetic process
ISN31_RS10695	COG2894	cell division
ISN31_RS10700	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
ISN31_RS10710	COG2205	protein histidine kinase activity
ISN31_RS10715	COG0745	RESPONSE REGULATOR receiver
ISN31_RS10725	COG2194	sulfuric ester hydrolase activity
ISN31_RS10840	COG2814	Major facilitator Superfamily
ISN31_RS10865	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ISN31_RS10865	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ISN31_RS10880	COG0753	catalase activity
ISN31_RS10905	COG1063	alcohol dehydrogenase
ISN31_RS10915	COG3459	Glycosyltransferase 36 associated
ISN31_RS11025	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ISN31_RS11035	COG0330	HflC and HflK could
ISN31_RS11040	COG0330	HflC and HflK could
ISN31_RS11045	COG0604	alcohol dehydrogenase
ISN31_RS11065	COG0678	peroxiredoxin activity
ISN31_RS11075	COG4953	penicillin-binding protein 1C
ISN31_RS11095	COG2373	Large extracellular alpha-helical protein
ISN31_RS11150	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ISN31_RS11165	COG0372	Belongs to the citrate synthase family
ISN31_RS11190	COG2161	toxin-antitoxin pair type II binding
ISN31_RS11195	COG4115	mRNA cleavage
ISN31_RS11215	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ISN31_RS11220	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ISN31_RS11225	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ISN31_RS11235	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ISN31_RS11240	COG1028	Short-chain dehydrogenase reductase Sdr
ISN31_RS11245	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ISN31_RS11250	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ISN31_RS11260	COG1399	metal-binding, possibly nucleic acid-binding protein
ISN31_RS11285	COG0714	Associated with various cellular activities
ISN31_RS11305	COG0537	adenosine 5'-monophosphoramidase activity
ISN31_RS11335	COG0314	molybdopterin synthase activity
ISN31_RS11340	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
ISN31_RS11345	COG0315	cyclic pyranopterin monophosphate synthase activity
ISN31_RS11355	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ISN31_RS11360	COG1234	tRNA 3'-trailer cleavage
ISN31_RS11370	COG0859	PFAM glycosyl transferase family 9
ISN31_RS11390	COG0631	protein serine/threonine phosphatase activity
ISN31_RS11395	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ISN31_RS11400	COG0328	RNA-DNA hybrid ribonuclease activity
ISN31_RS11410	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ISN31_RS11415	COG1388	LysM domain
ISN31_RS11415	COG3942	CHAP domain
ISN31_RS11450	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ISN31_RS11460	COG0544	peptidyl-prolyl cis-trans isomerase activity
ISN31_RS11505	COG0473	3-isopropylmalate dehydrogenase activity
ISN31_RS11520	COG4783	chaperone-mediated protein folding
ISN31_RS11535	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
ISN31_RS11540	COG0248	Ppx GppA phosphatase
ISN31_RS11545	COG0438	transferase activity, transferring glycosyl groups
ISN31_RS11555	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ISN31_RS11570	COG2833	Protein of unknown function (DUF455)
ISN31_RS11590	COG0285	dihydrofolate synthase activity
ISN31_RS11595	COG0588	phosphoglycerate mutase activity
ISN31_RS11615	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
ISN31_RS11620	COG4208	sulfate ABC transporter
ISN31_RS11625	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
ISN31_RS11630	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
ISN31_RS11635	COG0156	8-amino-7-oxononanoate synthase activity
ISN31_RS11655	COG2885	chlorophyll binding
ISN31_RS11675	COG0667	Aldo Keto reductase
ISN31_RS11685	COG0446	pyridine nucleotide-disulphide oxidoreductase
ISN31_RS11685	COG1902	pentaerythritol trinitrate reductase activity
ISN31_RS11730	COG0625	glutathione transferase activity
ISN31_RS11745	COG0039	L-malate dehydrogenase activity
ISN31_RS11755	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ISN31_RS11760	COG1217	gtp-binding protein TYPA
ISN31_RS11775	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
ISN31_RS11785	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
ISN31_RS11790	COG0203	ribosomal protein L17
ISN31_RS11815	COG0201	protein transport
ISN31_RS11825	COG1841	ribosomal large subunit assembly
ISN31_RS11850	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ISN31_RS11855	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ISN31_RS11860	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
ISN31_RS11870	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ISN31_RS11875	COG0255	Belongs to the universal ribosomal protein uL29 family
ISN31_RS11900	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ISN31_RS11905	COG0089	rRNA binding
ISN31_RS11910	COG0088	Forms part of the polypeptide exit tunnel
ISN31_RS11920	COG0051	transcription antitermination factor activity, RNA binding
ISN31_RS11925	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ISN31_RS11930	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ISN31_RS11945	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ISN31_RS11955	COG0222	ribosome binding
ISN31_RS11970	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ISN31_RS11975	COG0250	Participates in transcription elongation, termination and antitermination
ISN31_RS11980	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ISN31_RS11990	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ISN31_RS12010	COG0012	GTP binding
ISN31_RS12015	COG0193	aminoacyl-tRNA hydrolase activity
ISN31_RS12025	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ISN31_RS12035	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ISN31_RS12050	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ISN31_RS12055	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ISN31_RS12095	COG0488	(ABC) transporter
ISN31_RS12175	COG3634	alkyl hydroperoxide reductase activity
ISN31_RS12180	COG0583	DNA-binding transcription factor activity
ISN31_RS12195	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ISN31_RS12225	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ISN31_RS12230	COG0697	spore germination
ISN31_RS12275	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ISN31_RS12280	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ISN31_RS12290	COG2096	Adenosyltransferase
ISN31_RS12305	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
ISN31_RS12310	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ISN31_RS12315	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
ISN31_RS12320	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ISN31_RS12325	COG2967	ApaG domain
ISN31_RS12330	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
ISN31_RS12360	COG1704	LemA family
ISN31_RS12365	COG0861	Integral membrane protein TerC family
ISN31_RS12370	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
ISN31_RS12380	COG0642	Histidine kinase
ISN31_RS12395	COG4181	ATPase activity
ISN31_RS12400	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
ISN31_RS12420	COG4771	TonB-dependent receptor
ISN31_RS12430	COG0667	Aldo Keto reductase
ISN31_RS12435	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ISN31_RS12455	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ISN31_RS12480	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ISN31_RS12520	COG2226	methyltransferase
ISN31_RS12545	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
ISN31_RS12555	COG0494	nUDIX hydrolase
ISN31_RS12570	COG0739	heme binding
ISN31_RS12580	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
ISN31_RS12585	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ISN31_RS12595	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
ISN31_RS12600	COG1181	Belongs to the D-alanine--D-alanine ligase family
ISN31_RS12625	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ISN31_RS12640	COG3116	cell division
ISN31_RS12645	COG0275	rRNA processing
ISN31_RS12650	COG2001	Belongs to the MraZ family
ISN31_RS12685	COG0792	nuclease activity
ISN31_RS12695	COG0277	FAD linked oxidase domain protein
ISN31_RS12700	COG0745	RESPONSE REGULATOR receiver
ISN31_RS12705	COG2205	protein histidine kinase activity
ISN31_RS12715	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
ISN31_RS12720	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
ISN31_RS12740	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
ISN31_RS12745	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ISN31_RS12750	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ISN31_RS12765	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ISN31_RS12765	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ISN31_RS12775	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ISN31_RS12795	COG0488	(ABC) transporter
ISN31_RS12800	COG0242	peptide deformylase activity
ISN31_RS12815	COG1960	acyl-CoA dehydrogenase activity
ISN31_RS12825	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ISN31_RS12835	COG1696	Membrane protein involved in D-alanine export
ISN31_RS12855	COG1215	transferase activity, transferring glycosyl groups
ISN31_RS12865	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ISN31_RS12920	COG2188	Transcriptional regulator
ISN31_RS12930	COG1450	Type ii and iii secretion system protein
ISN31_RS12945	COG3166	PFAM Fimbrial assembly family protein
ISN31_RS12950	COG3156	type II secretion system protein K
ISN31_RS12955	COG4795	General secretion pathway protein
ISN31_RS12960	COG2165	general secretion pathway protein
ISN31_RS12965	COG4970	Tfp pilus assembly protein FimT
ISN31_RS12970	COG2165	general secretion pathway protein
ISN31_RS12975	COG1459	type II secretion system
ISN31_RS12980	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ISN31_RS12985	COG1404	Belongs to the peptidase S8 family
ISN31_RS12990	COG5295	Hep Hag repeat protein
ISN31_RS13000	COG0840	transmembrane signaling receptor activity
ISN31_RS13005	COG0047	phosphoribosylformylglycinamidine synthase activity
ISN31_RS13005	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ISN31_RS13010	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ISN31_RS13015	COG4974	Belongs to the 'phage' integrase family
ISN31_RS13040	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ISN31_RS13045	COG2927	DNA polymerase III (CHI subunit)
ISN31_RS13085	COG1183	phosphatidylcholine synthase activity
ISN31_RS13095	COG0442	prolyl-tRNA aminoacylation
ISN31_RS13110	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ISN31_RS13115	COG1127	ABC transporter
ISN31_RS13120	COG3218	ABC-type transport auxiliary lipoprotein component
ISN31_RS13120	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ISN31_RS13150	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
ISN31_RS13155	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ISN31_RS13160	COG0662	Cupin 2, conserved barrel domain protein
ISN31_RS13160	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
ISN31_RS13185	COG2086	electron transfer activity
ISN31_RS13200	COG0546	phosphoglycolate phosphatase activity
ISN31_RS13200	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
ISN31_RS13205	COG0277	FAD linked oxidase domain protein
ISN31_RS13210	COG0300	oxidoreductase activity
ISN31_RS13215	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ISN31_RS13235	COG0493	'glutamate synthase
ISN31_RS13270	COG0438	transferase activity, transferring glycosyl groups
ISN31_RS13270	COG1216	Glycosyl transferase, family 2
ISN31_RS13275	COG1216	Glycosyl transferase, family 2
ISN31_RS13275	COG0438	transferase activity, transferring glycosyl groups
ISN31_RS13280	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ISN31_RS13295	COG0626	cystathionine gamma-synthase activity
ISN31_RS13325	COG0625	glutathione transferase activity
ISN31_RS13340	COG0720	synthase
ISN31_RS13350	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
ISN31_RS13355	COG1956	GAF domain-containing protein
ISN31_RS13365	COG4206	TonB-dependent receptor
ISN31_RS13375	COG0546	phosphoglycolate phosphatase activity
ISN31_RS13400	COG0339	signal peptide processing
ISN31_RS13405	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ISN31_RS13415	COG2217	Heavy metal translocating P-type atpase
ISN31_RS13430	COG2132	Multicopper oxidase
ISN31_RS13445	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ISN31_RS13455	COG1136	(ABC) transporter
ISN31_RS13460	COG0577	efflux transmembrane transporter activity
ISN31_RS13460	COG1136	(ABC) transporter
ISN31_RS13465	COG0577	efflux transmembrane transporter activity
ISN31_RS13465	COG1136	(ABC) transporter
ISN31_RS13475	COG4191	Histidine kinase
ISN31_RS13485	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ISN31_RS13500	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ISN31_RS13515	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ISN31_RS13525	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ISN31_RS13535	COG0356	it plays a direct role in the translocation of protons across the membrane
ISN31_RS13550	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ISN31_RS13555	COG0508	dehydrogenase complex catalyzes the overall conversion of
ISN31_RS13590	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ISN31_RS13595	COG0697	spore germination
ISN31_RS13600	COG1666	GTP binding
ISN31_RS13610	COG1187	pseudouridine synthase activity
ISN31_RS13635	COG2205	protein histidine kinase activity
ISN31_RS13635	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISN31_RS13660	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ISN31_RS13725	COG0842	Transport permease protein
ISN31_RS13730	COG1131	(ABC) transporter
ISN31_RS13735	COG0025	NhaP-type Na H and K H
ISN31_RS13745	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
ISN31_RS13750	COG1573	uracil-dna glycosylase
ISN31_RS13760	COG3384	dioxygenase
ISN31_RS13785	COG0667	Aldo Keto reductase
ISN31_RS13795	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ISN31_RS13800	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ISN31_RS13820	COG3706	GGDEF domain
ISN31_RS13830	COG5001	Diguanylate cyclase
ISN31_RS13860	COG4106	trans-aconitate 2-methyltransferase activity
ISN31_RS13870	COG2076	Multidrug Resistance protein
ISN31_RS13880	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ISN31_RS13910	COG3275	phosphorelay sensor kinase activity
ISN31_RS13915	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
ISN31_RS13935	COG0531	amino acid
ISN31_RS13945	COG5297	Belongs to the glycosyl hydrolase family 6
ISN31_RS13945	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
ISN31_RS13960	COG0741	lytic transglycosylase activity
ISN31_RS13980	COG2207	Transcriptional regulator
ISN31_RS13990	COG0598	Magnesium transport protein CorA
ISN31_RS13995	COG1113	amino acid transport
ISN31_RS14000	COG0697	spore germination
ISN31_RS14025	COG2267	carboxylic ester hydrolase activity
ISN31_RS14145	COG0840	transmembrane signaling receptor activity
ISN31_RS14160	COG2353	YceI-like domain
ISN31_RS14190	COG0584	glycerophosphoryl diester phosphodiesterase
ISN31_RS14205	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
ISN31_RS14225	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ISN31_RS14230	COG0459	protein refolding
ISN31_RS14245	COG1324	tolerance protein
ISN31_RS14250	COG4232	protein-disulfide reductase activity
ISN31_RS14255	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ISN31_RS14265	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
ISN31_RS14270	COG0511	ligase activity, forming carbon-carbon bonds
ISN31_RS14275	COG0439	Biotin carboxylase
ISN31_RS14290	COG2264	protein methyltransferase activity
ISN31_RS14310	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
ISN31_RS14315	COG4589	Belongs to the CDS family
ISN31_RS14340	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ISN31_RS14345	COG0138	bifunctional purine biosynthesis protein purh
ISN31_RS14350	COG0151	Belongs to the GarS family
ISN31_RS14355	COG1289	transmembrane transporter activity
ISN31_RS14360	COG2814	Major facilitator Superfamily
ISN31_RS14400	COG2816	NAD+ diphosphatase activity
ISN31_RS14440	COG2906	2 iron, 2 sulfur cluster binding
ISN31_RS14445	COG1051	belongs to the nudix hydrolase family
ISN31_RS14470	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
ISN31_RS14485	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
ISN31_RS14490	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ISN31_RS14495	COG0730	response to heat
ISN31_RS14505	COG0134	indole-3-glycerol-phosphate synthase activity
ISN31_RS14510	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ISN31_RS14530	COG1597	lipid kinase activity
ISN31_RS14545	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
ISN31_RS14560	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ISN31_RS14565	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ISN31_RS14565	COG2111	Na H antiporter
ISN31_RS14570	COG1006	Multisubunit Na H antiporter MnhC subunit
ISN31_RS14575	COG0651	ATP synthesis coupled electron transport
ISN31_RS14580	COG1863	multisubunit Na H antiporter MnhE subunit
ISN31_RS14585	COG2212	antiporter activity
ISN31_RS14590	COG1320	monovalent cation:proton antiporter activity
ISN31_RS14595	COG0530	calcium, potassium:sodium antiporter activity
ISN31_RS14615	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
ISN31_RS14635	COG3104	oligopeptide transport
ISN31_RS14655	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ISN31_RS14670	COG0508	dehydrogenase complex catalyzes the overall conversion of
ISN31_RS14695	COG0513	Belongs to the DEAD box helicase family
ISN31_RS14725	COG2354	Protein conserved in bacteria
ISN31_RS14745	COG1196	nuclear chromosome segregation
ISN31_RS14745	COG3264	Mechanosensitive ion channel
ISN31_RS14750	COG0604	alcohol dehydrogenase
ISN31_RS14750	COG1028	Short-chain dehydrogenase reductase Sdr
ISN31_RS14750	COG3321	synthase
ISN31_RS14770	COG1595	DNA-templated transcription, initiation
ISN31_RS14785	COG1802	Transcriptional regulator
ISN31_RS14800	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
ISN31_RS14830	COG1414	Transcriptional regulator
ISN31_RS14835	COG0738	Major facilitator superfamily
ISN31_RS14840	COG3254	rhamnose metabolic process
ISN31_RS14845	COG4948	Mandelate Racemase Muconate Lactonizing
ISN31_RS14850	COG0179	Fumarylacetoacetate (FAA) hydrolase
ISN31_RS14855	COG1028	Short-chain dehydrogenase reductase Sdr
ISN31_RS14890	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ISN31_RS14905	COG4807	Protein conserved in bacteria
ISN31_RS14945	COG0823	Involved in the tonB-independent uptake of proteins
ISN31_RS14945	COG1506	peptidase
ISN31_RS15030	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ISN31_RS15055	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ISN31_RS15060	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ISN31_RS15065	COG0753	catalase activity
ISN31_RS15090	COG1136	(ABC) transporter
ISN31_RS15095	COG0577	efflux transmembrane transporter activity
ISN31_RS15115	COG0697	spore germination
ISN31_RS15130	COG0180	Tryptophanyl-tRNA synthetase
ISN31_RS15165	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
ISN31_RS15170	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
ISN31_RS15170	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
ISN31_RS15180	COG3228	Belongs to the MtfA family
ISN31_RS15210	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ISN31_RS15235	COG2084	Dehydrogenase
ISN31_RS15240	COG1902	pentaerythritol trinitrate reductase activity
ISN31_RS15250	COG2814	Major facilitator Superfamily
ISN31_RS15255	COG0583	DNA-binding transcription factor activity
ISN31_RS15270	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ISN31_RS15275	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ISN31_RS15285	COG1764	response to oxidative stress
ISN31_RS15290	COG1846	Transcriptional regulator
ISN31_RS15295	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
ISN31_RS15305	COG0697	spore germination
ISN31_RS15310	COG0523	cobalamin synthesis protein
ISN31_RS15320	COG1742	UPF0060 membrane protein
ISN31_RS15330	COG3245	cytochrome
ISN31_RS15340	COG1960	acyl-CoA dehydrogenase activity
ISN31_RS15345	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ISN31_RS15365	COG1278	Cold shock
ISN31_RS15385	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ISN31_RS15390	COG3387	PFAM Glycoside hydrolase 15-related
ISN31_RS15395	COG0745	RESPONSE REGULATOR receiver
ISN31_RS15410	COG1404	Belongs to the peptidase S8 family
ISN31_RS15420	COG3100	YcgL domain-containing protein
ISN31_RS15425	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ISN31_RS15435	COG0463	Glycosyl transferase, family 2
ISN31_RS15470	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ISN31_RS15485	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ISN31_RS15510	COG1294	oxidase, subunit
ISN31_RS15515	COG1271	oxidase subunit
ISN31_RS15535	COG0408	coproporphyrinogen oxidase activity
ISN31_RS15545	COG2323	membrane
ISN31_RS15550	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ISN31_RS15550	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ISN31_RS15565	COG0589	response to stress
ISN31_RS15590	COG0210	DNA helicase
ISN31_RS15640	COG0463	Glycosyl transferase, family 2
ISN31_RS15650	COG1475	DNA binding
ISN31_RS15655	COG1192	Involved in chromosome partitioning
ISN31_RS15660	COG0357	Ribosomal RNA small subunit methyltransferase G
ISN31_RS15670	COG2091	lysine biosynthetic process via aminoadipic acid
ISN31_RS15695	COG0477	Major facilitator Superfamily
ISN31_RS15715	COG1971	Probably functions as a manganese efflux pump
ISN31_RS15720	COG2205	protein histidine kinase activity
ISN31_RS15730	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ISN31_RS15735	COG3459	Glycosyltransferase 36 associated
ISN31_RS15740	COG2211	Major facilitator Superfamily
ISN31_RS15745	COG3265	gluconokinase activity
ISN31_RS15760	COG2911	Protein conserved in bacteria
ISN31_RS15765	COG0729	surface antigen
ISN31_RS15785	COG3132	Protein of unknown function, DUF480
ISN31_RS15815	COG0284	orotidine-5'-phosphate decarboxylase activity
ISN31_RS15830	COG1609	Transcriptional regulator
ISN31_RS15840	COG2937	Belongs to the GPAT DAPAT family
ISN31_RS15865	COG2211	Major facilitator Superfamily
ISN31_RS15880	COG3693	PFAM glycoside hydrolase, family 10
ISN31_RS15885	COG1904	glucuronate isomerase
ISN31_RS15900	COG3386	PFAM SMP-30 Gluconolaconase
ISN31_RS15930	COG0246	Mannitol dehydrogenase
ISN31_RS15935	COG1472	Belongs to the glycosyl hydrolase 3 family
ISN31_RS15945	COG4948	Mandelate Racemase Muconate Lactonizing
ISN31_RS15955	COG3661	Belongs to the glycosyl hydrolase 67 family
ISN31_RS15965	COG2115	Belongs to the xylose isomerase family
ISN31_RS15970	COG0037	tRNA processing
ISN31_RS15990	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ISN31_RS16000	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ISN31_RS16010	COG0805	protein transport
ISN31_RS16020	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ISN31_RS16020	COG0519	Catalyzes the synthesis of GMP from XMP
ISN31_RS16025	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ISN31_RS16045	COG0210	DNA helicase
ISN31_RS16050	COG1435	thymidine kinase activity
ISN31_RS16060	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
ISN31_RS16075	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ISN31_RS16090	COG1119	ATPase activity
ISN31_RS16100	COG0706	membrane insertase activity
ISN31_RS16105	COG0594	ribonuclease P activity
ISN31_RS16120	COG0592	DNA-directed DNA polymerase activity
ISN31_RS16125	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ISN31_RS16130	COG0187	DNA topoisomerase II activity
ISN31_RS16135	COG1266	CAAX protease self-immunity
ISN31_RS16140	COG0501	Belongs to the peptidase M48B family
ISN31_RS16170	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
ISN31_RS16180	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ISN31_RS16195	COG1280	lysine exporter protein (LysE YggA)
ISN31_RS16210	COG4772	TonB-dependent receptor
ISN31_RS16220	COG3284	Transcriptional regulator
ISN31_RS16225	COG1012	belongs to the aldehyde dehydrogenase family
ISN31_RS16260	COG1304	FMN binding
ISN31_RS16265	COG2186	Transcriptional regulator
ISN31_RS16285	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISN31_RS16370	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ISN31_RS16390	COG4771	TonB-dependent receptor
ISN31_RS16435	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ISN31_RS16450	COG3507	Belongs to the glycosyl hydrolase 43 family
ISN31_RS16455	COG1609	Transcriptional regulator
ISN31_RS16465	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
ISN31_RS16470	COG1028	Short-chain dehydrogenase reductase Sdr
ISN31_RS16485	COG3186	Phenylalanine-4-hydroxylase
ISN31_RS16490	COG1522	sequence-specific DNA binding
ISN31_RS16530	COG1752	Esterase of the alpha-beta hydrolase superfamily
ISN31_RS16545	COG0671	phosphoesterase, PA-phosphatase related
ISN31_RS16560	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ISN31_RS16595	COG1929	Belongs to the glycerate kinase type-1 family
ISN31_RS16605	COG0531	amino acid
ISN31_RS16610	COG4566	intracellular signal transduction
ISN31_RS16615	COG4191	Histidine kinase
ISN31_RS16635	COG1322	Protein conserved in bacteria
ISN31_RS16640	COG0386	Belongs to the glutathione peroxidase family
ISN31_RS16645	COG2853	Lipoprotein
ISN31_RS16660	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ISN31_RS16665	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ISN31_RS16670	COG1127	ABC transporter
ISN31_RS16675	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
ISN31_RS16680	COG1074	ATP-dependent DNA helicase activity
ISN31_RS16685	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ISN31_RS16705	COG0537	adenosine 5'-monophosphoramidase activity
ISN31_RS16730	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
ISN31_RS16780	COG0477	Major facilitator Superfamily
ISN31_RS16785	COG0302	gtp cyclohydrolase
ISN31_RS16810	COG0730	response to heat
ISN31_RS16830	COG2951	lytic endotransglycosylase activity
ISN31_RS16890	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
ISN31_RS16895	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
ISN31_RS16900	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
ISN31_RS16905	COG0493	'glutamate synthase
ISN31_RS16910	COG0067	glutamate synthase
ISN31_RS16910	COG0069	glutamate synthase activity
ISN31_RS16910	COG0070	glutamate synthase
ISN31_RS16955	COG1111	helicase
ISN31_RS16955	COG1205	dead DEAH box helicase
ISN31_RS16985	COG2271	Major facilitator Superfamily
ISN31_RS17040	COG2062	phosphohistidine phosphatase, SixA
ISN31_RS17050	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ISN31_RS17055	COG2050	protein possibly involved in aromatic compounds catabolism
ISN31_RS17065	COG2267	carboxylic ester hydrolase activity
ISN31_RS17075	COG1881	PFAM PEBP family protein
ISN31_RS17080	COG1968	undecaprenyl-diphosphatase activity
ISN31_RS17085	COG0174	glutamine synthetase
ISN31_RS17090	COG0347	Belongs to the P(II) protein family
ISN31_RS17095	COG0004	ammonium transporteR
ISN31_RS17100	COG3852	Histidine kinase
ISN31_RS17105	COG2204	response regulator
ISN31_RS17110	COG2032	superoxide dismutase activity
ISN31_RS17115	COG2032	superoxide dismutase activity
ISN31_RS17125	COG0183	Belongs to the thiolase family
ISN31_RS17165	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
ISN31_RS17170	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ISN31_RS17180	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ISN31_RS17190	COG0612	Peptidase, M16
ISN31_RS17200	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ISN31_RS17205	COG3177	Filamentation induced by cAMP protein fic
ISN31_RS17220	COG0596	Alpha beta hydrolase
ISN31_RS17230	COG0727	PFAM Uncharacterised protein family (UPF0153)
ISN31_RS17235	COG0318	PFAM AMP-dependent synthetase and ligase
ISN31_RS17250	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ISN31_RS17260	COG1181	Belongs to the D-alanine--D-alanine ligase family
ISN31_RS17275	COG4232	protein-disulfide reductase activity
ISN31_RS17280	COG0564	pseudouridine synthase activity
ISN31_RS17300	COG0339	signal peptide processing
ISN31_RS17320	COG0583	DNA-binding transcription factor activity
ISN31_RS17325	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
ISN31_RS17330	COG2224	Isocitrate lyase
ISN31_RS17365	COG0659	secondary active sulfate transmembrane transporter activity
ISN31_RS17395	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ISN31_RS17400	COG2130	NADP-dependent
ISN31_RS17415	COG1187	pseudouridine synthase activity
ISN31_RS17425	COG1643	Atp-dependent helicase
ISN31_RS17430	COG0084	hydrolase, TatD family'
ISN31_RS17520	COG0842	Transport permease protein
ISN31_RS17525	COG1131	(ABC) transporter
ISN31_RS17530	COG0543	2 iron, 2 sulfur cluster binding
ISN31_RS17530	COG0633	Ferredoxin
ISN31_RS17540	COG1476	TRANSCRIPTIONal
ISN31_RS17550	COG4555	ABC transporter
ISN31_RS17570	COG0625	glutathione transferase activity
ISN31_RS17645	COG1199	ATP-dependent helicase activity
ISN31_RS17690	COG0628	permease
ISN31_RS17730	COG2133	pyrroloquinoline quinone binding
ISN31_RS17765	COG0754	glutathionylspermidine amidase activity
ISN31_RS17775	COG0714	Associated with various cellular activities
ISN31_RS17810	COG1522	sequence-specific DNA binding
ISN31_RS17825	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
ISN31_RS17840	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISN31_RS17845	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ISN31_RS17870	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ISN31_RS17905	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ISN31_RS17915	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ISN31_RS17935	COG2224	Isocitrate lyase
ISN31_RS17970	COG0076	glutamate decarboxylase activity
ISN31_RS18000	COG2267	carboxylic ester hydrolase activity
ISN31_RS18015	COG0606	chelatase, subunit chli
ISN31_RS18020	COG2960	long-chain fatty acid transporting porin activity
ISN31_RS18040	COG1166	arginine decarboxylase activity
ISN31_RS18045	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ISN31_RS18050	COG1819	glycosyl
ISN31_RS18055	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
ISN31_RS18055	COG2755	lipolytic protein G-D-S-L family
ISN31_RS18060	COG0583	DNA-binding transcription factor activity
ISN31_RS18080	COG4221	oxidoreductase activity
ISN31_RS18100	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ISN31_RS18120	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ISN31_RS18130	COG2814	Major facilitator Superfamily
ISN31_RS18140	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
ISN31_RS18145	COG0739	heme binding
ISN31_RS18150	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ISN31_RS18180	COG1064	alcohol dehydrogenase
ISN31_RS18185	COG2234	aminopeptidase activity
ISN31_RS18195	COG4942	peptidase
ISN31_RS18200	COG0793	Belongs to the peptidase S41A family
ISN31_RS18235	COG0531	amino acid
ISN31_RS18240	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ISN31_RS18240	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
ISN31_RS18245	COG1486	melibiose metabolic process
ISN31_RS18265	COG1565	acr, cog1565
ISN31_RS18265	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ISN31_RS18270	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ISN31_RS18275	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
ISN31_RS18305	COG0109	protoheme IX farnesyltransferase activity
ISN31_RS18320	COG0358	DNA primase activity
ISN31_RS18325	COG1295	ribonuclease BN
ISN31_RS18345	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ISN31_RS18365	COG2308	Evidence 4 Homologs of previously reported genes of
ISN31_RS18380	COG2133	pyrroloquinoline quinone binding
ISN31_RS18400	COG0531	amino acid
ISN31_RS18410	COG4948	Mandelate Racemase Muconate Lactonizing
ISN31_RS18420	COG4771	TonB-dependent receptor
ISN31_RS18450	COG3501	Rhs element vgr protein
ISN31_RS18450	COG3409	Peptidoglycan-binding domain 1 protein
ISN31_RS18485	COG5383	Protein conserved in bacteria
ISN31_RS18500	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ISN31_RS18505	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISN31_RS18520	COG1652	LysM domain
ISN31_RS18530	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
ISN31_RS18535	COG1518	maintenance of DNA repeat elements
ISN31_RS18575	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ISN31_RS18585	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
ISN31_RS18595	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ISN31_RS18600	COG3118	belongs to the thioredoxin family
ISN31_RS18610	COG2884	Cell division ATP-binding protein ftsE
ISN31_RS18615	COG2177	Part of the ABC transporter FtsEX involved in
ISN31_RS18620	COG2201	protein-glutamate methylesterase activity
ISN31_RS18625	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
ISN31_RS18630	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ISN31_RS18640	COG1252	NADH dehydrogenase
ISN31_RS18650	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ISN31_RS18660	COG0534	Mate efflux family protein
ISN31_RS18665	COG0616	signal peptide processing
ISN31_RS18675	COG1028	Short-chain dehydrogenase reductase Sdr
ISN31_RS18690	COG0009	L-threonylcarbamoyladenylate synthase
ISN31_RS18695	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ISN31_RS18695	COG1754	DNA topoisomerase type I activity
ISN31_RS18700	COG1714	RDD family
ISN31_RS18715	COG0758	DNA mediated transformation
ISN31_RS18720	COG1652	LysM domain
ISN31_RS18725	COG0242	peptide deformylase activity
ISN31_RS18730	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ISN31_RS18735	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ISN31_RS18735	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ISN31_RS18740	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
ISN31_RS18750	COG3307	-O-antigen
ISN31_RS18775	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ISN31_RS18790	COG1490	D-aminoacyl-tRNA deacylase activity
ISN31_RS18795	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ISN31_RS18825	COG1609	Transcriptional regulator
ISN31_RS18835	COG0366	Alpha amylase catalytic
ISN31_RS18840	COG0366	Alpha amylase catalytic
ISN31_RS18910	COG1309	transcriptional regulator
ISN31_RS18950	COG0840	transmembrane signaling receptor activity
ISN31_RS18970	COG3546	catalase activity
ISN31_RS18975	COG3685	Protein conserved in bacteria
ISN31_RS18980	COG3685	Protein conserved in bacteria
ISN31_RS18985	COG1028	Short-chain dehydrogenase reductase Sdr
ISN31_RS18995	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
ISN31_RS19010	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ISN31_RS19025	COG0028	Belongs to the TPP enzyme family
ISN31_RS19030	COG4191	Histidine kinase
ISN31_RS19035	COG2204	response regulator
ISN31_RS19060	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
ISN31_RS19065	COG0732	type I restriction modification DNA specificity domain
ISN31_RS19075	COG3645	SOS response
ISN31_RS19105	COG1116	anion transmembrane transporter activity
ISN31_RS19105	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ISN31_RS19110	COG2223	nitrite transmembrane transporter activity
ISN31_RS19115	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ISN31_RS19120	COG2146	nitrite reductase [NAD(P)H] activity
ISN31_RS19125	COG0243	molybdopterin cofactor binding
ISN31_RS19155	COG1640	4-alpha-glucanotransferase
ISN31_RS19160	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
ISN31_RS19180	COG0745	RESPONSE REGULATOR receiver
ISN31_RS19205	COG0181	hydroxymethylbilane synthase activity
ISN31_RS19230	COG1733	regulation of RNA biosynthetic process
ISN31_RS19245	COG1505	serine-type exopeptidase activity
ISN31_RS19250	COG0436	Aminotransferase
ISN31_RS19260	COG2832	Protein of unknown function (DUF454)
ISN31_RS19270	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ISN31_RS19315	COG2226	methyltransferase
ISN31_RS19325	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ISN31_RS19330	COG0308	aminopeptidase N
ISN31_RS19335	COG0508	dehydrogenase complex catalyzes the overall conversion of
ISN31_RS19335	COG0596	Alpha beta hydrolase
ISN31_RS19360	COG2010	Cytochrome c
ISN31_RS19370	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
ISN31_RS19380	COG3284	Transcriptional regulator
ISN31_RS19385	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISN31_RS19390	COG1077	Cell shape determining protein MreB Mrl
ISN31_RS19405	COG0768	penicillin binding
ISN31_RS19410	COG0772	Belongs to the SEDS family
ISN31_RS19425	COG2951	lytic endotransglycosylase activity
ISN31_RS19435	COG1686	Belongs to the peptidase S11 family
ISN31_RS19515	COG0321	lipoyl(octanoyl) transferase activity
ISN31_RS19520	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ISN31_RS19550	COG1051	belongs to the nudix hydrolase family
ISN31_RS19550	COG1056	cytidyltransferase-related domain
ISN31_RS19570	COG1090	epimerase
ISN31_RS19580	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
ISN31_RS19585	COG0673	inositol 2-dehydrogenase activity
ISN31_RS19590	COG2823	Periplasmic or secreted lipoprotein
ISN31_RS19600	COG2202	Pas domain
ISN31_RS19600	COG2205	protein histidine kinase activity
ISN31_RS19605	COG0784	Response regulator, receiver
ISN31_RS19610	COG4191	Histidine kinase
ISN31_RS19620	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ISN31_RS19625	COG1028	Short-chain dehydrogenase reductase Sdr
ISN31_RS19640	COG4305	rare lipoprotein A
ISN31_RS19650	COG3250	beta-galactosidase activity
ISN31_RS19665	COG2188	Transcriptional regulator
ISN31_RS19670	COG0738	Major facilitator superfamily
ISN31_RS19675	COG1609	Transcriptional regulator
ISN31_RS19680	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ISN31_RS19685	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ISN31_RS19695	COG0617	tRNA 3'-terminal CCA addition
ISN31_RS19715	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ISN31_RS19765	COG2205	protein histidine kinase activity
ISN31_RS19780	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
ISN31_RS19785	COG3791	Glutathione-dependent formaldehyde-activating
ISN31_RS19830	COG0804	urea catabolic process
ISN31_RS19835	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ISN31_RS19855	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
ISN31_RS19885	COG1162	GTPase activity
ISN31_RS19910	COG2211	Major facilitator Superfamily
ISN31_RS19920	COG1028	Short-chain dehydrogenase reductase Sdr
ISN31_RS19925	COG2851	Citrate transporter
ISN31_RS19940	COG0642	Histidine kinase
ISN31_RS19960	COG4191	Histidine kinase
ISN31_RS19970	COG1301	dicarboxylic acid transport
ISN31_RS19975	COG0280	phosphate acetyltransferase
ISN31_RS19975	COG0281	malic enzyme
ISN31_RS20040	COG1560	Kdo2-lipid A biosynthetic process
ISN31_RS20045	COG1519	Transferase
ISN31_RS20050	COG1538	Outer membrane efflux protein
ISN31_RS20055	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
ISN31_RS20065	COG3706	GGDEF domain
ISN31_RS20070	COG0473	3-isopropylmalate dehydrogenase activity
ISN31_RS20075	COG0066	3-isopropylmalate dehydratase activity
ISN31_RS20085	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ISN31_RS20095	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ISN31_RS20115	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
ISN31_RS20120	COG0840	transmembrane signaling receptor activity
ISN31_RS20140	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
ISN31_RS20150	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
ISN31_RS20170	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ISN31_RS20190	COG0671	phosphoesterase, PA-phosphatase related
ISN31_RS20205	COG1940	carbohydrate kinase activity
ISN31_RS20215	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ISN31_RS20225	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ISN31_RS20250	COG1773	rubredoxin
ISN31_RS20265	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
ISN31_RS20275	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ISN31_RS20300	COG3079	Belongs to the UPF0149 family
ISN31_RS20305	COG0006	proline dipeptidase activity
ISN31_RS20310	COG0006	proline dipeptidase activity
ISN31_RS20330	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ISN31_RS20335	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ISN31_RS20340	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
ISN31_RS20345	COG1561	YicC-like family, N-terminal region
ISN31_RS20350	COG0194	GDP metabolic process
ISN31_RS20355	COG1758	RNA polymerase activity
ISN31_RS20360	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ISN31_RS20370	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ISN31_RS20380	COG0254	rRNA binding
ISN31_RS20385	COG0372	Belongs to the citrate synthase family
ISN31_RS20400	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
ISN31_RS20430	COG0714	Associated with various cellular activities
ISN31_RS20460	COG1301	dicarboxylic acid transport
ISN31_RS20465	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ISN31_RS20500	COG0739	heme binding
ISN31_RS20505	COG1376	ErfK ybiS ycfS ynhG family protein
ISN31_RS20530	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
ISN31_RS20535	COG4149	molybdate abc transporter
ISN31_RS20540	COG0725	ABC transporter, periplasmic molybdate-binding protein
ISN31_RS20550	COG0640	Transcriptional regulator
ISN31_RS20580	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ISN31_RS20630	COG3588	fructose-bisphosphate aldolase
ISN31_RS20635	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
ISN31_RS20670	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ISN31_RS20700	COG2198	Histidine kinase
ISN31_RS20700	COG0784	Response regulator, receiver
ISN31_RS20700	COG2205	protein histidine kinase activity
ISN31_RS20705	COG1393	Belongs to the ArsC family
ISN31_RS20735	COG0175	sulfate reduction
ISN31_RS20790	COG4993	Dehydrogenase
ISN31_RS20795	COG4993	Dehydrogenase
ISN31_RS20850	COG3878	Protein conserved in bacteria
ISN31_RS20910	COG0840	transmembrane signaling receptor activity