locus-tag	class	description
ISN32_RS00030	COG1064	alcohol dehydrogenase
ISN32_RS00035	COG2234	aminopeptidase activity
ISN32_RS00045	COG4942	peptidase
ISN32_RS00050	COG0793	Belongs to the peptidase S41A family
ISN32_RS00095	COG1486	melibiose metabolic process
ISN32_RS00110	COG1565	acr, cog1565
ISN32_RS00110	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ISN32_RS00115	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ISN32_RS00120	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
ISN32_RS00150	COG0109	protoheme IX farnesyltransferase activity
ISN32_RS00165	COG0358	DNA primase activity
ISN32_RS00170	COG1295	ribonuclease BN
ISN32_RS00190	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ISN32_RS00210	COG2308	Evidence 4 Homologs of previously reported genes of
ISN32_RS00225	COG2133	pyrroloquinoline quinone binding
ISN32_RS00245	COG0531	amino acid
ISN32_RS00255	COG4948	Mandelate Racemase Muconate Lactonizing
ISN32_RS00265	COG4771	TonB-dependent receptor
ISN32_RS00295	COG3409	Peptidoglycan-binding domain 1 protein
ISN32_RS00295	COG3501	Rhs element vgr protein
ISN32_RS00330	COG5383	Protein conserved in bacteria
ISN32_RS00345	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ISN32_RS00350	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISN32_RS00365	COG1652	LysM domain
ISN32_RS00375	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
ISN32_RS00380	COG1518	maintenance of DNA repeat elements
ISN32_RS00430	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
ISN32_RS00460	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ISN32_RS00465	COG3118	belongs to the thioredoxin family
ISN32_RS00475	COG2884	Cell division ATP-binding protein ftsE
ISN32_RS00480	COG2177	Part of the ABC transporter FtsEX involved in
ISN32_RS00485	COG2201	protein-glutamate methylesterase activity
ISN32_RS00490	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
ISN32_RS00495	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ISN32_RS00500	COG2860	membrane
ISN32_RS00505	COG1252	NADH dehydrogenase
ISN32_RS00515	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ISN32_RS00525	COG0534	Mate efflux family protein
ISN32_RS00530	COG0616	signal peptide processing
ISN32_RS00540	COG1028	Short-chain dehydrogenase reductase Sdr
ISN32_RS00555	COG0009	L-threonylcarbamoyladenylate synthase
ISN32_RS00560	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ISN32_RS00560	COG1754	DNA topoisomerase type I activity
ISN32_RS00565	COG1714	RDD family
ISN32_RS00580	COG0758	DNA mediated transformation
ISN32_RS00585	COG1652	LysM domain
ISN32_RS00590	COG0242	peptide deformylase activity
ISN32_RS00595	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ISN32_RS00600	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ISN32_RS00600	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ISN32_RS00605	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
ISN32_RS00615	COG3307	-O-antigen
ISN32_RS00640	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ISN32_RS00655	COG1490	D-aminoacyl-tRNA deacylase activity
ISN32_RS00660	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ISN32_RS00690	COG1609	Transcriptional regulator
ISN32_RS00700	COG0366	Alpha amylase catalytic
ISN32_RS00705	COG0366	Alpha amylase catalytic
ISN32_RS00755	COG1309	transcriptional regulator
ISN32_RS00795	COG0840	transmembrane signaling receptor activity
ISN32_RS00815	COG3546	catalase activity
ISN32_RS00820	COG3685	Protein conserved in bacteria
ISN32_RS00825	COG3685	Protein conserved in bacteria
ISN32_RS00830	COG1028	Short-chain dehydrogenase reductase Sdr
ISN32_RS00840	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
ISN32_RS00855	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ISN32_RS00870	COG0028	Belongs to the TPP enzyme family
ISN32_RS00875	COG4191	Histidine kinase
ISN32_RS00880	COG2204	response regulator
ISN32_RS00910	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
ISN32_RS00915	COG0732	type I restriction modification DNA specificity domain
ISN32_RS00925	COG3645	SOS response
ISN32_RS00955	COG1116	anion transmembrane transporter activity
ISN32_RS00955	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ISN32_RS00960	COG2223	nitrite transmembrane transporter activity
ISN32_RS00965	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ISN32_RS00970	COG2146	nitrite reductase [NAD(P)H] activity
ISN32_RS00975	COG0243	molybdopterin cofactor binding
ISN32_RS01000	COG1640	4-alpha-glucanotransferase
ISN32_RS01005	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
ISN32_RS01050	COG0181	hydroxymethylbilane synthase activity
ISN32_RS01070	COG1733	regulation of RNA biosynthetic process
ISN32_RS01085	COG1505	serine-type exopeptidase activity
ISN32_RS01090	COG0436	Aminotransferase
ISN32_RS01100	COG2832	Protein of unknown function (DUF454)
ISN32_RS01110	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ISN32_RS01155	COG2226	methyltransferase
ISN32_RS01165	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ISN32_RS01170	COG0308	aminopeptidase N
ISN32_RS01175	COG0596	Alpha beta hydrolase
ISN32_RS01175	COG0508	dehydrogenase complex catalyzes the overall conversion of
ISN32_RS01200	COG2010	Cytochrome c
ISN32_RS01210	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
ISN32_RS01220	COG3284	Transcriptional regulator
ISN32_RS01225	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISN32_RS01230	COG1077	Cell shape determining protein MreB Mrl
ISN32_RS01235	COG1792	Involved in formation and maintenance of cell shape
ISN32_RS01245	COG0768	penicillin binding
ISN32_RS01250	COG0772	Belongs to the SEDS family
ISN32_RS01265	COG2951	lytic endotransglycosylase activity
ISN32_RS01275	COG1686	Belongs to the peptidase S11 family
ISN32_RS01310	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ISN32_RS01340	COG1051	belongs to the nudix hydrolase family
ISN32_RS01340	COG1056	cytidyltransferase-related domain
ISN32_RS01360	COG1090	epimerase
ISN32_RS01370	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
ISN32_RS01375	COG0673	inositol 2-dehydrogenase activity
ISN32_RS01380	COG2823	Periplasmic or secreted lipoprotein
ISN32_RS01390	COG2202	Pas domain
ISN32_RS01390	COG2205	protein histidine kinase activity
ISN32_RS01395	COG0784	Response regulator, receiver
ISN32_RS01400	COG4191	Histidine kinase
ISN32_RS01410	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ISN32_RS01415	COG1028	Short-chain dehydrogenase reductase Sdr
ISN32_RS01430	COG4305	rare lipoprotein A
ISN32_RS01450	COG3250	beta-galactosidase activity
ISN32_RS01465	COG2188	Transcriptional regulator
ISN32_RS01470	COG0738	Major facilitator superfamily
ISN32_RS01475	COG1609	Transcriptional regulator
ISN32_RS01480	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ISN32_RS01485	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ISN32_RS01495	COG0617	tRNA 3'-terminal CCA addition
ISN32_RS01515	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ISN32_RS01565	COG2205	protein histidine kinase activity
ISN32_RS01580	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
ISN32_RS01585	COG3791	Glutathione-dependent formaldehyde-activating
ISN32_RS01595	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ISN32_RS01640	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ISN32_RS01660	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
ISN32_RS01760	COG1162	GTPase activity
ISN32_RS01785	COG2211	Major facilitator Superfamily
ISN32_RS01795	COG1028	Short-chain dehydrogenase reductase Sdr
ISN32_RS01800	COG2851	Citrate transporter
ISN32_RS01815	COG0642	Histidine kinase
ISN32_RS01835	COG4191	Histidine kinase
ISN32_RS01845	COG1301	dicarboxylic acid transport
ISN32_RS01850	COG0281	malic enzyme
ISN32_RS01850	COG0280	phosphate acetyltransferase
ISN32_RS01915	COG1560	Kdo2-lipid A biosynthetic process
ISN32_RS01920	COG1519	Transferase
ISN32_RS01925	COG1538	Outer membrane efflux protein
ISN32_RS01930	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
ISN32_RS01935	COG1309	transcriptional regulator
ISN32_RS01940	COG3706	GGDEF domain
ISN32_RS01945	COG0473	3-isopropylmalate dehydrogenase activity
ISN32_RS01950	COG0066	3-isopropylmalate dehydratase activity
ISN32_RS01970	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ISN32_RS01990	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
ISN32_RS01995	COG0840	transmembrane signaling receptor activity
ISN32_RS02020	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
ISN32_RS02030	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
ISN32_RS02050	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ISN32_RS02060	COG0671	phosphoesterase, PA-phosphatase related
ISN32_RS02075	COG1940	carbohydrate kinase activity
ISN32_RS02085	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ISN32_RS02105	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ISN32_RS02130	COG1773	rubredoxin
ISN32_RS02145	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
ISN32_RS02155	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ISN32_RS02180	COG3079	Belongs to the UPF0149 family
ISN32_RS02185	COG0006	proline dipeptidase activity
ISN32_RS02190	COG0006	proline dipeptidase activity
ISN32_RS02210	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ISN32_RS02215	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ISN32_RS02220	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
ISN32_RS02225	COG1561	YicC-like family, N-terminal region
ISN32_RS02230	COG0194	GDP metabolic process
ISN32_RS02235	COG1758	RNA polymerase activity
ISN32_RS02240	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ISN32_RS02250	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ISN32_RS02260	COG0254	rRNA binding
ISN32_RS02265	COG0372	Belongs to the citrate synthase family
ISN32_RS02280	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
ISN32_RS02310	COG0714	Associated with various cellular activities
ISN32_RS02340	COG1301	dicarboxylic acid transport
ISN32_RS02345	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ISN32_RS02375	COG0739	heme binding
ISN32_RS02380	COG1376	ErfK ybiS ycfS ynhG family protein
ISN32_RS02415	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
ISN32_RS02420	COG4149	molybdate abc transporter
ISN32_RS02425	COG0725	ABC transporter, periplasmic molybdate-binding protein
ISN32_RS02435	COG0640	Transcriptional regulator
ISN32_RS02460	COG3047	cAMP biosynthetic process
ISN32_RS02465	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ISN32_RS02510	COG0469	pyruvate kinase activity
ISN32_RS02515	COG3588	fructose-bisphosphate aldolase
ISN32_RS02520	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
ISN32_RS02555	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ISN32_RS02570	COG1648	precorrin-2 dehydrogenase activity
ISN32_RS02570	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ISN32_RS02585	COG0784	Response regulator, receiver
ISN32_RS02585	COG2198	Histidine kinase
ISN32_RS02585	COG2205	protein histidine kinase activity
ISN32_RS02590	COG1393	Belongs to the ArsC family
ISN32_RS02620	COG0175	sulfate reduction
ISN32_RS02625	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ISN32_RS02630	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ISN32_RS02640	COG2895	sulfate adenylyltransferase (ATP) activity
ISN32_RS02640	COG0529	Catalyzes the synthesis of activated sulfate
ISN32_RS02645	COG0840	transmembrane signaling receptor activity
ISN32_RS02665	COG1115	amino acid carrier protein
ISN32_RS02675	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ISN32_RS02690	COG1609	Transcriptional regulator
ISN32_RS02710	COG0179	Fumarylacetoacetate (FAA) hydrolase
ISN32_RS02725	COG3273	potassium ion transport
ISN32_RS02725	COG0471	metal ion transport
ISN32_RS02735	COG2022	thiamine diphosphate biosynthetic process
ISN32_RS02755	COG0174	glutamine synthetase
ISN32_RS02760	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
ISN32_RS02770	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
ISN32_RS02785	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ISN32_RS02810	COG3511	phospholipase C
ISN32_RS02820	COG0189	ligase activity
ISN32_RS02830	COG0745	RESPONSE REGULATOR receiver
ISN32_RS02845	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
ISN32_RS02905	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ISN32_RS02905	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ISN32_RS02915	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ISN32_RS02930	COG1174	glycine betaine transport
ISN32_RS02935	COG1125	glycine betaine transport
ISN32_RS02945	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ISN32_RS02950	COG0564	pseudouridine synthase activity
ISN32_RS02975	COG3387	PFAM Glycoside hydrolase 15-related
ISN32_RS03025	COG0542	response to heat
ISN32_RS03050	COG0019	diaminopimelate decarboxylase activity
ISN32_RS03055	COG4264	IucA IucC family
ISN32_RS03060	COG2814	Major facilitator Superfamily
ISN32_RS03065	COG4264	IucA IucC family
ISN32_RS03075	COG4772	TonB-dependent receptor
ISN32_RS03085	COG4651	solute:proton antiporter activity
ISN32_RS03085	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ISN32_RS03145	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ISN32_RS03145	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ISN32_RS03165	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
ISN32_RS03205	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ISN32_RS03210	COG1404	Belongs to the peptidase S8 family
ISN32_RS03245	COG1295	ribonuclease BN
ISN32_RS03250	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ISN32_RS03270	COG0521	Mo-molybdopterin cofactor biosynthetic process
ISN32_RS03275	COG5297	Belongs to the glycosyl hydrolase family 6
ISN32_RS03365	COG3537	Alpha-1,2-mannosidase
ISN32_RS03390	COG1472	Belongs to the glycosyl hydrolase 3 family
ISN32_RS03400	COG3525	Glycosyl hydrolase, family 20, catalytic domain
ISN32_RS03405	COG1388	LysM domain
ISN32_RS03405	COG3858	chitin binding
ISN32_RS03420	COG0837	glucose binding
ISN32_RS03430	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ISN32_RS03440	COG0494	nUDIX hydrolase
ISN32_RS03445	COG1218	3'(2'),5'-bisphosphate nucleotidase
ISN32_RS03450	COG3956	TIGRFAM MazG family protein
ISN32_RS03455	COG1742	UPF0060 membrane protein
ISN32_RS03460	COG0330	HflC and HflK could
ISN32_RS03495	COG0697	spore germination
ISN32_RS03525	COG2124	cytochrome p450
ISN32_RS03530	COG2124	cytochrome p450
ISN32_RS03535	COG1141	Ferredoxin
ISN32_RS03540	COG1028	Short-chain dehydrogenase reductase Sdr
ISN32_RS03545	COG2124	cytochrome p450
ISN32_RS03550	COG0142	geranyltranstransferase activity
ISN32_RS03555	COG1657	PFAM Prenyltransferase squalene oxidase
ISN32_RS03565	COG1304	FMN binding
ISN32_RS03585	COG4206	TonB-dependent receptor
ISN32_RS03595	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
ISN32_RS03600	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ISN32_RS03605	COG0463	Glycosyl transferase, family 2
ISN32_RS03610	COG0517	IMP dehydrogenase activity
ISN32_RS03615	COG2982	Protein involved in outer membrane biogenesis
ISN32_RS03620	COG1272	protein, Hemolysin III
ISN32_RS03625	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
ISN32_RS03635	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ISN32_RS03640	COG0626	cystathionine gamma-synthase activity
ISN32_RS03645	COG0527	aspartate kinase activity
ISN32_RS03645	COG0460	homoserine dehydrogenase
ISN32_RS03650	COG2267	carboxylic ester hydrolase activity
ISN32_RS03660	COG1760	l-serine dehydratase
ISN32_RS03675	COG3038	cytochrome b561
ISN32_RS03695	COG2814	Major facilitator Superfamily
ISN32_RS03700	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ISN32_RS03710	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISN32_RS03715	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ISN32_RS03790	COG0519	Catalyzes the synthesis of GMP from XMP
ISN32_RS03805	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ISN32_RS03825	COG0840	transmembrane signaling receptor activity
ISN32_RS03835	COG1113	amino acid transport
ISN32_RS03855	COG2239	Acts as a magnesium transporter
ISN32_RS03860	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ISN32_RS03865	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISN32_RS03875	COG1660	Displays ATPase and GTPase activities
ISN32_RS03885	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISN32_RS03900	COG1137	ATPase activity
ISN32_RS03915	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
ISN32_RS03960	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ISN32_RS03985	COG0628	permease
ISN32_RS03995	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
ISN32_RS04000	COG3178	'Phosphotransferase
ISN32_RS04015	COG1555	photosystem II stabilization
ISN32_RS04035	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ISN32_RS04040	COG1477	protein flavinylation
ISN32_RS04065	COG4774	siderophore transport
ISN32_RS04070	COG2146	nitrite reductase [NAD(P)H] activity
ISN32_RS04080	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ISN32_RS04085	COG0719	Fe-S assembly protein
ISN32_RS04090	COG0396	ATPase activity
ISN32_RS04095	COG0719	Fe-S assembly protein
ISN32_RS04110	COG0693	protein deglycase activity
ISN32_RS04125	COG0739	heme binding
ISN32_RS04140	COG1764	response to oxidative stress
ISN32_RS04150	COG0384	phenazine biosynthesis protein PhzF
ISN32_RS04155	COG0527	aspartate kinase activity
ISN32_RS04180	COG0142	geranyltranstransferase activity
ISN32_RS04185	COG0629	single-stranded DNA binding
ISN32_RS04190	COG3550	peptidyl-serine autophosphorylation
ISN32_RS04205	COG3104	oligopeptide transport
ISN32_RS04210	COG1297	OPT oligopeptide transporter protein
ISN32_RS04215	COG0823	Involved in the tonB-independent uptake of proteins
ISN32_RS04215	COG1506	peptidase
ISN32_RS04235	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ISN32_RS04240	COG2879	small protein
ISN32_RS04245	COG1966	Carbon starvation protein
ISN32_RS04280	COG2211	Major facilitator Superfamily
ISN32_RS04310	COG2203	Gaf domain
ISN32_RS04310	COG3706	GGDEF domain
ISN32_RS04310	COG4251	negative regulation of phosphorylation
ISN32_RS04310	COG5001	Diguanylate cyclase
ISN32_RS04315	COG0835	chemotaxis
ISN32_RS04320	COG0840	transmembrane signaling receptor activity
ISN32_RS04325	COG0840	transmembrane signaling receptor activity
ISN32_RS04330	COG0840	transmembrane signaling receptor activity
ISN32_RS04335	COG2198	Histidine kinase
ISN32_RS04335	COG0643	Histidine kinase
ISN32_RS04345	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ISN32_RS04365	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
ISN32_RS04375	COG2205	protein histidine kinase activity
ISN32_RS04415	COG0735	belongs to the Fur family
ISN32_RS04450	COG1529	Aldehyde oxidase and xanthine dehydrogenase
ISN32_RS04455	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
ISN32_RS04460	COG2080	2 iron, 2 sulfur cluster binding
ISN32_RS04545	COG3547	Transposase (IS116 IS110 IS902 family)
ISN32_RS04570	COG1187	pseudouridine synthase activity
ISN32_RS04595	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ISN32_RS04620	COG1132	(ABC) transporter
ISN32_RS04645	COG3547	Transposase (IS116 IS110 IS902 family)
ISN32_RS04650	COG0583	DNA-binding transcription factor activity
ISN32_RS04690	COG1981	membrane
ISN32_RS04715	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ISN32_RS04720	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ISN32_RS04730	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ISN32_RS04735	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ISN32_RS04740	COG0750	zinc metalloprotease
ISN32_RS04745	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
ISN32_RS04750	COG0575	Belongs to the CDS family
ISN32_RS04755	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ISN32_RS04765	COG0528	UMP kinase activity
ISN32_RS04775	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ISN32_RS04815	COG0024	Methionine aminopeptidase
ISN32_RS04830	COG1393	Belongs to the ArsC family
ISN32_RS04835	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ISN32_RS04845	COG0367	asparagine synthase
ISN32_RS04880	COG1566	PFAM secretion protein HlyD family protein
ISN32_RS04885	COG2814	Major facilitator Superfamily
ISN32_RS04920	COG0557	exoribonuclease II activity
ISN32_RS04930	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ISN32_RS04940	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ISN32_RS04960	COG0704	Plays a role in the regulation of phosphate uptake
ISN32_RS04970	COG0581	inorganic phosphate transmembrane transporter activity
ISN32_RS04980	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ISN32_RS04985	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ISN32_RS05005	COG0659	secondary active sulfate transmembrane transporter activity
ISN32_RS05010	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ISN32_RS05020	COG1024	Enoyl-CoA hydratase
ISN32_RS05075	COG5002	protein histidine kinase activity
ISN32_RS05075	COG2205	protein histidine kinase activity
ISN32_RS05075	COG0784	Response regulator, receiver
ISN32_RS05080	COG2733	membrane
ISN32_RS05100	COG0686	Belongs to the AlaDH PNT family
ISN32_RS05105	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ISN32_RS05110	COG1396	sequence-specific DNA binding
ISN32_RS05110	COG1917	Cupin 2, conserved barrel domain protein
ISN32_RS05115	COG1012	belongs to the aldehyde dehydrogenase family
ISN32_RS05135	COG2223	nitrite transmembrane transporter activity
ISN32_RS05145	COG0243	molybdopterin cofactor binding
ISN32_RS05160	COG0477	Major facilitator Superfamily
ISN32_RS05170	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ISN32_RS05175	COG0174	glutamine synthetase
ISN32_RS05180	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
ISN32_RS05185	COG0174	glutamine synthetase
ISN32_RS05195	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
ISN32_RS05220	COG3842	ATPase activity
ISN32_RS05225	COG1176	ABC-type spermidine putrescine transport system, permease component I
ISN32_RS05230	COG1177	transmembrane transport
ISN32_RS05235	COG1012	belongs to the aldehyde dehydrogenase family
ISN32_RS05250	COG4535	Mg2 and Co2 transporter CorC
ISN32_RS05265	COG1702	phosphate starvation-inducible protein PhoH
ISN32_RS05280	COG0741	lytic transglycosylase activity
ISN32_RS05285	COG0723	plastoquinol--plastocyanin reductase activity
ISN32_RS05290	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ISN32_RS05300	COG2857	Cytochrome c1
ISN32_RS05305	COG0625	glutathione transferase activity
ISN32_RS05310	COG2969	positive regulation of protein catabolic process
ISN32_RS05350	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
ISN32_RS05355	COG1028	Short-chain dehydrogenase reductase Sdr
ISN32_RS05360	COG2095	MarC family integral membrane protein
ISN32_RS05370	COG1611	Belongs to the LOG family
ISN32_RS05375	COG3275	phosphorelay sensor kinase activity
ISN32_RS05600	COG3179	chitinase
ISN32_RS05645	COG4695	Portal protein
ISN32_RS05710	COG0556	nucleotide-excision repair
ISN32_RS05740	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
ISN32_RS05750	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ISN32_RS05755	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ISN32_RS05805	COG0438	transferase activity, transferring glycosyl groups
ISN32_RS05810	COG0438	transferase activity, transferring glycosyl groups
ISN32_RS05820	COG0438	transferase activity, transferring glycosyl groups
ISN32_RS05840	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ISN32_RS05850	COG1960	acyl-CoA dehydrogenase activity
ISN32_RS05885	COG1570	exodeoxyribonuclease VII activity
ISN32_RS05890	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ISN32_RS05895	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
ISN32_RS05895	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ISN32_RS05900	COG0802	atpase or kinase
ISN32_RS05905	COG0860	N-Acetylmuramoyl-L-alanine amidase
ISN32_RS05910	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
ISN32_RS05930	COG1028	Short-chain dehydrogenase reductase Sdr
ISN32_RS05950	COG2081	HI0933 family
ISN32_RS05955	COG4681	YaeQ
ISN32_RS05960	COG0564	pseudouridine synthase activity
ISN32_RS05970	COG0625	glutathione transferase activity
ISN32_RS05975	COG0657	acetylesterase activity
ISN32_RS05980	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
ISN32_RS06005	COG0513	Belongs to the DEAD box helicase family
ISN32_RS06010	COG0488	(ABC) transporter
ISN32_RS06025	COG4290	ribonuclease
ISN32_RS06030	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ISN32_RS06040	COG1472	Belongs to the glycosyl hydrolase 3 family
ISN32_RS06080	COG1846	Transcriptional regulator
ISN32_RS06095	COG0386	Belongs to the glutathione peroxidase family
ISN32_RS06120	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ISN32_RS06170	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
ISN32_RS06175	COG0084	hydrolase, TatD family'
ISN32_RS06190	COG1960	acyl-CoA dehydrogenase activity
ISN32_RS06200	COG0305	Participates in initiation and elongation during chromosome replication
ISN32_RS06205	COG0415	Belongs to the DNA photolyase family
ISN32_RS06220	COG0583	DNA-binding transcription factor activity
ISN32_RS06235	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISN32_RS06275	COG1404	Belongs to the peptidase S8 family
ISN32_RS06280	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ISN32_RS06285	COG2867	negative regulation of translational initiation
ISN32_RS06295	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ISN32_RS06300	COG0735	belongs to the Fur family
ISN32_RS06305	COG0497	DNA recombination
ISN32_RS06310	COG1420	regulation of RNA biosynthetic process
ISN32_RS06315	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ISN32_RS06320	COG0443	Heat shock 70 kDa protein
ISN32_RS06325	COG0484	heat shock protein binding
ISN32_RS06330	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
ISN32_RS06335	COG0287	Prephenate dehydrogenase
ISN32_RS06335	COG1605	Chorismate mutase
ISN32_RS06345	COG1132	(ABC) transporter
ISN32_RS06370	COG3547	Transposase (IS116 IS110 IS902 family)
ISN32_RS06380	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ISN32_RS06410	COG2166	iron-sulfur cluster assembly
ISN32_RS06425	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ISN32_RS06430	COG0137	argininosuccinate synthase activity
ISN32_RS06435	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ISN32_RS06440	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ISN32_RS06450	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ISN32_RS06455	COG0165	Argininosuccinate lyase
ISN32_RS06475	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ISN32_RS06500	COG1501	Belongs to the glycosyl hydrolase 31 family
ISN32_RS06510	COG1070	Carbohydrate kinase
ISN32_RS06515	COG2115	Belongs to the xylose isomerase family
ISN32_RS06520	COG0477	Major facilitator Superfamily
ISN32_RS06525	COG0860	N-Acetylmuramoyl-L-alanine amidase
ISN32_RS06545	COG0617	tRNA 3'-terminal CCA addition
ISN32_RS06555	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ISN32_RS06570	COG0166	Belongs to the GPI family
ISN32_RS06645	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
ISN32_RS06660	COG0671	phosphoesterase, PA-phosphatase related
ISN32_RS06685	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ISN32_RS06690	COG0167	dihydroorotate dehydrogenase activity
ISN32_RS06705	COG1012	belongs to the aldehyde dehydrogenase family
ISN32_RS06720	COG0460	homoserine dehydrogenase
ISN32_RS06720	COG0527	aspartate kinase activity
ISN32_RS06730	COG2951	lytic endotransglycosylase activity
ISN32_RS06740	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ISN32_RS06755	COG0124	histidyl-tRNA synthetase
ISN32_RS06765	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
ISN32_RS06770	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ISN32_RS06775	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ISN32_RS06785	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ISN32_RS06800	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ISN32_RS06800	COG0140	phosphoribosyl-ATP diphosphatase activity
ISN32_RS06815	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
ISN32_RS06820	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
ISN32_RS06825	COG0235	Class ii aldolase
ISN32_RS06830	COG0531	amino acid
ISN32_RS06835	COG0531	amino acid
ISN32_RS06850	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ISN32_RS06855	COG0277	FAD linked oxidase domain protein
ISN32_RS06875	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ISN32_RS06890	COG1024	Enoyl-CoA hydratase
ISN32_RS06945	COG1741	Belongs to the pirin family
ISN32_RS06950	COG0583	DNA-binding transcription factor activity
ISN32_RS06970	COG0352	thiamine-phosphate diphosphorylase activity
ISN32_RS06970	COG0351	phosphomethylpyrimidine kinase
ISN32_RS06985	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
ISN32_RS06990	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ISN32_RS07000	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ISN32_RS07010	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
ISN32_RS07015	COG3734	2-keto-3-deoxy-galactonokinase
ISN32_RS07030	COG0800	Aldolase
ISN32_RS07065	COG0784	Response regulator, receiver
ISN32_RS07065	COG2205	protein histidine kinase activity
ISN32_RS07065	COG2198	Histidine kinase
ISN32_RS07070	COG1024	Enoyl-CoA hydratase
ISN32_RS07075	COG0318	PFAM AMP-dependent synthetase and ligase
ISN32_RS07105	COG3706	GGDEF domain
ISN32_RS07130	COG0840	transmembrane signaling receptor activity
ISN32_RS07140	COG0840	transmembrane signaling receptor activity
ISN32_RS07150	COG0835	chemotaxis
ISN32_RS07160	COG0840	transmembrane signaling receptor activity
ISN32_RS07170	COG0840	transmembrane signaling receptor activity
ISN32_RS07175	COG0840	transmembrane signaling receptor activity
ISN32_RS07180	COG0840	transmembrane signaling receptor activity
ISN32_RS07185	COG0840	transmembrane signaling receptor activity
ISN32_RS07195	COG0840	transmembrane signaling receptor activity
ISN32_RS07200	COG0840	transmembrane signaling receptor activity
ISN32_RS07205	COG0840	transmembrane signaling receptor activity
ISN32_RS07210	COG0840	transmembrane signaling receptor activity
ISN32_RS07225	COG0745	RESPONSE REGULATOR receiver
ISN32_RS07235	COG0835	chemotaxis
ISN32_RS07240	COG1192	Involved in chromosome partitioning
ISN32_RS07250	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
ISN32_RS07255	COG0643	Histidine kinase
ISN32_RS07255	COG2198	Histidine kinase
ISN32_RS07255	COG0784	Response regulator, receiver
ISN32_RS07260	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
ISN32_RS07305	COG1684	flagellar biosynthetic protein fliR
ISN32_RS07310	COG1987	bacterial-type flagellum assembly
ISN32_RS07320	COG3190	flagellar
ISN32_RS07370	COG1677	Flagellar hook-basal body complex protein FliE
ISN32_RS07415	COG1028	Short-chain dehydrogenase reductase Sdr
ISN32_RS07420	COG1028	Short-chain dehydrogenase reductase Sdr
ISN32_RS07425	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ISN32_RS07445	COG2201	protein-glutamate methylesterase activity
ISN32_RS07450	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
ISN32_RS07455	COG2197	response regulator
ISN32_RS07475	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
ISN32_RS07480	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ISN32_RS07485	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ISN32_RS07490	COG1256	bacterial-type flagellum assembly
ISN32_RS07490	COG1256	bacterial-type flagellum assembly
ISN32_RS07490	COG4786	Flagellar basal body rod
ISN32_RS07490	COG4786	Flagellar basal body rod
ISN32_RS07505	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
ISN32_RS07520	COG1749	Flagellar hook protein flgE
ISN32_RS07530	COG1558	bacterial-type flagellum-dependent cell motility
ISN32_RS07540	COG0835	chemotaxis
ISN32_RS07540	COG0784	Response regulator, receiver
ISN32_RS07605	COG2915	High frequency lysogenization protein hflD homolog
ISN32_RS07610	COG0482	sulfurtransferase activity
ISN32_RS07630	COG0542	response to heat
ISN32_RS07650	COG0492	ferredoxin-NADP+ reductase activity
ISN32_RS07655	COG1674	ftsk spoiiie
ISN32_RS07675	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ISN32_RS07680	COG0038	chloride channel
ISN32_RS07735	COG1595	DNA-templated transcription, initiation
ISN32_RS07755	COG3038	cytochrome b561
ISN32_RS07785	COG2244	polysaccharide biosynthetic process
ISN32_RS07805	COG4106	trans-aconitate 2-methyltransferase activity
ISN32_RS07825	COG0438	transferase activity, transferring glycosyl groups
ISN32_RS07830	COG0438	transferase activity, transferring glycosyl groups
ISN32_RS07850	COG1132	(ABC) transporter
ISN32_RS07880	COG2801	Transposase and inactivated derivatives
ISN32_RS07885	COG1022	Amp-dependent synthetase and ligase
ISN32_RS07920	COG0512	Glutamine amidotransferase of anthranilate synthase
ISN32_RS07940	COG2801	Transposase and inactivated derivatives
ISN32_RS07965	COG1530	ribonuclease E activity
ISN32_RS07980	COG0428	transporter
ISN32_RS07995	COG0316	Belongs to the HesB IscA family
ISN32_RS07995	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
ISN32_RS08015	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISN32_RS08035	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ISN32_RS08040	COG2957	Belongs to the agmatine deiminase family
ISN32_RS08050	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ISN32_RS08055	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
ISN32_RS08060	COG0539	negative regulation of cytoplasmic translation
ISN32_RS08065	COG0776	regulation of translation
ISN32_RS08075	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
ISN32_RS08080	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ISN32_RS08090	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ISN32_RS08095	COG0183	Belongs to the thiolase family
ISN32_RS08100	COG1024	Enoyl-CoA hydratase
ISN32_RS08100	COG1250	3-hydroxyacyl-CoA dehydrogenase
ISN32_RS08115	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ISN32_RS08125	COG1426	Protein conserved in bacteria
ISN32_RS08135	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ISN32_RS08145	COG0746	molybdenum cofactor guanylyltransferase activity
ISN32_RS08155	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ISN32_RS08160	COG0475	glutathione-regulated potassium exporter activity
ISN32_RS08160	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ISN32_RS08180	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ISN32_RS08190	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ISN32_RS08190	COG0519	Catalyzes the synthesis of GMP from XMP
ISN32_RS08220	COG0519	Catalyzes the synthesis of GMP from XMP
ISN32_RS08220	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ISN32_RS08220	COG0519	Catalyzes the synthesis of GMP from XMP
ISN32_RS08220	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ISN32_RS08295	COG1487	ribonuclease activity
ISN32_RS08300	COG4691	Plasmid stability protein
ISN32_RS08355	COG1501	Belongs to the glycosyl hydrolase 31 family
ISN32_RS08360	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
ISN32_RS08370	COG1914	H( )-stimulated, divalent metal cation uptake system
ISN32_RS08385	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
ISN32_RS08390	COG0668	transmembrane transport
ISN32_RS08400	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
ISN32_RS08415	COG1028	Short-chain dehydrogenase reductase Sdr
ISN32_RS08420	COG1183	phosphatidylcholine synthase activity
ISN32_RS08430	COG3243	poly(R)-hydroxyalkanoic acid synthase
ISN32_RS08450	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ISN32_RS08450	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
ISN32_RS08460	COG4191	Histidine kinase
ISN32_RS08460	COG0784	Response regulator, receiver
ISN32_RS08465	COG2183	response to ionizing radiation
ISN32_RS08540	COG1649	PFAM Uncharacterised BCR, COG1649
ISN32_RS08545	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ISN32_RS08550	COG1304	FMN binding
ISN32_RS08560	COG0346	lactoylglutathione lyase activity
ISN32_RS08575	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ISN32_RS08600	COG1024	Enoyl-CoA hydratase
ISN32_RS08605	COG1024	Enoyl-CoA hydratase
ISN32_RS08615	COG1024	Enoyl-CoA hydratase
ISN32_RS08635	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
ISN32_RS08650	COG1247	-acetyltransferase
ISN32_RS08660	COG0653	protein targeting
ISN32_RS08675	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ISN32_RS08680	COG1393	Belongs to the ArsC family
ISN32_RS08685	COG0431	NADPH-dependent FMN reductase
ISN32_RS08690	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
ISN32_RS08710	COG4644	lycopene metabolic process
ISN32_RS08785	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ISN32_RS08795	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ISN32_RS08800	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ISN32_RS08810	COG0505	Belongs to the CarA family
ISN32_RS08820	COG2258	MOSC domain
ISN32_RS08825	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ISN32_RS08855	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ISN32_RS08865	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ISN32_RS08870	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
ISN32_RS09025	COG3179	chitinase
ISN32_RS09180	COG2801	Transposase and inactivated derivatives
ISN32_RS09190	COG2963	transposase activity
ISN32_RS09205	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ISN32_RS09220	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ISN32_RS09230	COG1663	tetraacyldisaccharide 4'-kinase activity
ISN32_RS09235	COG1132	(ABC) transporter
ISN32_RS09245	COG0811	peptide transport
ISN32_RS09265	COG4591	ABC-type transport system involved in lipoprotein release permease component
ISN32_RS09275	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
ISN32_RS09290	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
ISN32_RS09295	COG2009	succinate dehydrogenase
ISN32_RS09310	COG3842	ATPase activity
ISN32_RS09315	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ISN32_RS09330	COG0129	dihydroxy-acid dehydratase activity
ISN32_RS09345	COG0395	ABC-type sugar transport system, permease component
ISN32_RS09380	COG2350	Protein conserved in bacteria
ISN32_RS09385	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
ISN32_RS09390	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
ISN32_RS09395	COG1187	pseudouridine synthase activity
ISN32_RS09420	COG0436	Aminotransferase
ISN32_RS09425	COG4133	protoheme IX ABC transporter activity
ISN32_RS09475	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ISN32_RS09480	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
ISN32_RS09485	COG4988	ABC transporter
ISN32_RS09495	COG1294	oxidase, subunit
ISN32_RS09545	COG2137	regulation of response to DNA damage stimulus
ISN32_RS09550	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ISN32_RS09555	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ISN32_RS09560	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ISN32_RS09565	COG1546	Belongs to the CinA family
ISN32_RS09570	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ISN32_RS09580	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ISN32_RS09585	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ISN32_RS09590	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ISN32_RS09595	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
ISN32_RS09600	COG1534	Rna-binding protein
ISN32_RS09615	COG1238	metal cluster binding
ISN32_RS09625	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
ISN32_RS09640	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ISN32_RS09645	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ISN32_RS09650	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
ISN32_RS09665	COG0504	CTP synthase activity
ISN32_RS09685	COG0306	phosphate transporter
ISN32_RS09695	COG1253	flavin adenine dinucleotide binding
ISN32_RS09710	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ISN32_RS09745	COG0069	glutamate synthase activity
ISN32_RS09750	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
ISN32_RS09760	COG1609	Transcriptional regulator
ISN32_RS09765	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ISN32_RS09765	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISN32_RS09770	COG1105	Belongs to the carbohydrate kinase PfkB family
ISN32_RS09775	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISN32_RS09775	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISN32_RS09805	COG1136	(ABC) transporter
ISN32_RS09805	COG0577	efflux transmembrane transporter activity
ISN32_RS09865	COG0583	DNA-binding transcription factor activity
ISN32_RS09890	COG0077	Prephenate dehydratase
ISN32_RS09890	COG1605	Chorismate mutase
ISN32_RS09895	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
ISN32_RS09900	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ISN32_RS09940	COG4221	oxidoreductase activity
ISN32_RS09955	COG1228	amidohydrolase
ISN32_RS09970	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
ISN32_RS10005	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
ISN32_RS10015	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
ISN32_RS10025	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ISN32_RS10060	COG0316	Belongs to the HesB IscA family
ISN32_RS10130	COG0288	reversible hydration of carbon dioxide
ISN32_RS10140	COG1289	transmembrane transporter activity
ISN32_RS10145	COG3844	kynureninase activity
ISN32_RS10155	COG2925	Exonuclease
ISN32_RS10205	COG2902	Dehydrogenase
ISN32_RS10215	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISN32_RS10220	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ISN32_RS10225	COG1960	acyl-CoA dehydrogenase activity
ISN32_RS10230	COG2226	methyltransferase
ISN32_RS10235	COG1410	methionine synthase
ISN32_RS10235	COG0646	methionine synthase
ISN32_RS10240	COG0646	methionine synthase
ISN32_RS10240	COG1410	methionine synthase
ISN32_RS10250	COG2755	lipolytic protein G-D-S-L family
ISN32_RS10250	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
ISN32_RS10260	COG2900	Belongs to the SlyX family
ISN32_RS10275	COG0386	Belongs to the glutathione peroxidase family
ISN32_RS10285	COG1725	Transcriptional regulator
ISN32_RS10290	COG1131	(ABC) transporter
ISN32_RS10330	COG2850	peptidyl-arginine hydroxylation
ISN32_RS10360	COG3547	Transposase (IS116 IS110 IS902 family)
ISN32_RS10365	COG4677	pectinesterase activity
ISN32_RS10395	COG0402	S-adenosylhomocysteine deaminase activity
ISN32_RS10400	COG3548	integral membrane protein
ISN32_RS10410	COG1509	lysine 2,3-aminomutase activity
ISN32_RS10415	COG5001	Diguanylate cyclase
ISN32_RS10415	COG3706	GGDEF domain
ISN32_RS10415	COG2203	Gaf domain
ISN32_RS10415	COG4251	negative regulation of phosphorylation
ISN32_RS10440	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ISN32_RS10445	COG1862	Preprotein translocase
ISN32_RS10455	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
ISN32_RS10465	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ISN32_RS10475	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
ISN32_RS10480	COG3291	Pkd domain containing protein
ISN32_RS10485	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ISN32_RS10490	COG0405	Gamma-glutamyltransferase
ISN32_RS10495	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ISN32_RS10510	COG0742	ribosomal rna small subunit methyltransferase
ISN32_RS10535	COG4771	TonB-dependent receptor
ISN32_RS10545	COG3507	Belongs to the glycosyl hydrolase 43 family
ISN32_RS10580	COG0531	amino acid
ISN32_RS10595	COG0006	proline dipeptidase activity
ISN32_RS10605	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ISN32_RS10620	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ISN32_RS10625	COG3938	Belongs to the proline racemase family
ISN32_RS10635	COG0552	protein localization to endoplasmic reticulum
ISN32_RS10640	COG1194	a g-specific adenine glycosylase
ISN32_RS10685	COG0835	chemotaxis
ISN32_RS10690	COG0840	transmembrane signaling receptor activity
ISN32_RS10695	COG0840	transmembrane signaling receptor activity
ISN32_RS10715	COG3300	MHYT domain
ISN32_RS10715	COG5001	Diguanylate cyclase
ISN32_RS10720	COG1185	polyribonucleotide nucleotidyltransferase activity
ISN32_RS10730	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
ISN32_RS10745	COG0195	Participates in both transcription termination and antitermination
ISN32_RS10760	COG1007	ATP synthesis coupled electron transport
ISN32_RS10800	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
ISN32_RS10805	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
ISN32_RS10810	COG0649	NAD binding
ISN32_RS10815	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ISN32_RS10825	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ISN32_RS10855	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
ISN32_RS10920	COG2890	protein-(glutamine-N5) methyltransferase activity
ISN32_RS10930	COG0688	phosphatidylethanolamine metabolic process
ISN32_RS10935	COG0741	lytic transglycosylase activity
ISN32_RS10940	COG0433	COG0433 Predicted ATPase
ISN32_RS10945	COG0494	nUDIX hydrolase
ISN32_RS10960	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ISN32_RS10980	COG1714	RDD family
ISN32_RS10985	COG0717	Belongs to the dCTP deaminase family
ISN32_RS10990	COG0489	protein tyrosine kinase activity
ISN32_RS11000	COG4771	TonB-dependent receptor
ISN32_RS11010	COG4771	TonB-dependent receptor
ISN32_RS11015	COG0457	Tetratricopeptide repeat
ISN32_RS11030	COG3590	peptidase
ISN32_RS11070	COG0697	spore germination
ISN32_RS11090	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ISN32_RS11095	COG2311	Membrane
ISN32_RS11100	COG1047	Peptidyl-prolyl cis-trans
ISN32_RS11105	COG0791	NLP P60 protein
ISN32_RS11110	COG0791	NLP P60 protein
ISN32_RS11125	COG1607	acyl-coa hydrolase
ISN32_RS11135	COG1301	dicarboxylic acid transport
ISN32_RS11140	COG1785	Belongs to the alkaline phosphatase family
ISN32_RS11150	COG0037	tRNA processing
ISN32_RS11155	COG1722	exodeoxyribonuclease VII activity
ISN32_RS11160	COG0142	geranyltranstransferase activity
ISN32_RS11170	COG1858	cytochrome C peroxidase
ISN32_RS11195	COG2815	serine threonine protein kinase
ISN32_RS11195	COG0515	serine threonine protein kinase
ISN32_RS11200	COG0631	protein serine/threonine phosphatase activity
ISN32_RS11290	COG0312	modulator of DNA gyrase
ISN32_RS11300	COG0312	modulator of DNA gyrase
ISN32_RS11320	COG2968	Membrane
ISN32_RS11335	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
ISN32_RS11350	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ISN32_RS11365	COG0495	leucyl-tRNA aminoacylation
ISN32_RS11375	COG3118	belongs to the thioredoxin family
ISN32_RS11390	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
ISN32_RS11400	COG2040	homocysteine
ISN32_RS11405	COG0833	amino acid
ISN32_RS11415	COG0346	lactoylglutathione lyase activity
ISN32_RS11435	COG2878	Part of a membrane complex involved in electron transport
ISN32_RS11450	COG1595	DNA-templated transcription, initiation
ISN32_RS11475	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ISN32_RS11495	COG0251	oxidation-reduction process
ISN32_RS11505	COG0392	lysyltransferase activity
ISN32_RS11505	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
ISN32_RS11535	COG2814	Major facilitator Superfamily
ISN32_RS11540	COG1902	pentaerythritol trinitrate reductase activity
ISN32_RS11545	COG2824	Alkylphosphonate utilization operon protein PhnA
ISN32_RS11550	COG1047	Peptidyl-prolyl cis-trans
ISN32_RS11555	COG1077	Cell shape determining protein MreB Mrl
ISN32_RS11590	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ISN32_RS11600	COG1451	nucleotide metabolic process
ISN32_RS11620	COG2205	protein histidine kinase activity
ISN32_RS11620	COG0784	Response regulator, receiver
ISN32_RS11620	COG2198	Histidine kinase
ISN32_RS11630	COG2186	Transcriptional regulator
ISN32_RS11635	COG3250	beta-galactosidase activity
ISN32_RS11700	COG1703	isobutyryl-CoA mutase activity
ISN32_RS11700	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ISN32_RS11700	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ISN32_RS11730	COG0183	Belongs to the thiolase family
ISN32_RS11740	COG0443	Heat shock 70 kDa protein
ISN32_RS11770	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
ISN32_RS11770	COG1793	dna ligase
ISN32_RS11775	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
ISN32_RS11775	COG1793	dna ligase
ISN32_RS11780	COG1201	RNA secondary structure unwinding
ISN32_RS11790	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ISN32_RS11795	COG1278	Cold shock
ISN32_RS11800	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
ISN32_RS11805	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
ISN32_RS11810	COG1472	Belongs to the glycosyl hydrolase 3 family
ISN32_RS11820	COG2954	triphosphatase activity
ISN32_RS11830	COG0745	RESPONSE REGULATOR receiver
ISN32_RS11840	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ISN32_RS11855	COG0681	Belongs to the peptidase S26 family
ISN32_RS11860	COG0481	GTPase activity
ISN32_RS11865	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ISN32_RS11880	COG1024	Enoyl-CoA hydratase
ISN32_RS11880	COG1250	3-hydroxyacyl-CoA dehydrogenase
ISN32_RS11900	COG2855	membrane
ISN32_RS11915	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ISN32_RS11945	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
ISN32_RS11955	COG0534	Mate efflux family protein
ISN32_RS11960	COG0335	large ribosomal subunit rRNA binding
ISN32_RS11965	COG0336	Belongs to the RNA methyltransferase TrmD family
ISN32_RS11970	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ISN32_RS11985	COG2070	2-Nitropropane dioxygenase
ISN32_RS11990	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ISN32_RS12015	COG0475	glutathione-regulated potassium exporter activity
ISN32_RS12025	COG0625	glutathione transferase activity
ISN32_RS12030	COG1082	Xylose isomerase domain protein TIM barrel
ISN32_RS12040	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISN32_RS12045	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISN32_RS12050	COG1129	ABC transporter
ISN32_RS12055	COG1879	ABC-type sugar transport system periplasmic component
ISN32_RS12060	COG1012	belongs to the aldehyde dehydrogenase family
ISN32_RS12080	COG0129	dihydroxy-acid dehydratase activity
ISN32_RS12110	COG2207	Transcriptional regulator
ISN32_RS12155	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ISN32_RS12180	COG4794	Type iii secretion
ISN32_RS12210	COG0745	RESPONSE REGULATOR receiver
ISN32_RS12235	COG1595	DNA-templated transcription, initiation
ISN32_RS12265	COG0156	8-amino-7-oxononanoate synthase activity
ISN32_RS12275	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
ISN32_RS12280	COG1845	cytochrome c oxidase, subunit III
ISN32_RS12285	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ISN32_RS12320	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ISN32_RS12335	COG0196	riboflavin kinase activity
ISN32_RS12350	COG0728	peptidoglycan biosynthetic process
ISN32_RS12360	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ISN32_RS12365	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ISN32_RS12370	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ISN32_RS12375	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ISN32_RS12380	COG0824	Thioesterase
ISN32_RS12390	COG1024	Enoyl-CoA hydratase
ISN32_RS12395	COG1946	Acyl-CoA thioesterase
ISN32_RS12410	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
ISN32_RS12475	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ISN32_RS12520	COG1643	Atp-dependent helicase
ISN32_RS12525	COG0783	Belongs to the Dps family
ISN32_RS12530	COG0514	ATP-dependent DNA helicase (RecQ)
ISN32_RS12550	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
ISN32_RS12555	COG0602	queuosine metabolic process
ISN32_RS12565	COG2885	chlorophyll binding
ISN32_RS12580	COG0848	biopolymer transport protein
ISN32_RS12590	COG0824	Thioesterase
ISN32_RS12595	COG2255	four-way junction helicase activity
ISN32_RS12600	COG3158	transport of potassium into the cell
ISN32_RS12605	COG0632	four-way junction helicase activity
ISN32_RS12615	COG0217	transcriptional regulatory protein
ISN32_RS12655	COG3142	Participates in the control of copper homeostasis
ISN32_RS12660	COG1446	asparaginase
ISN32_RS12690	COG2201	protein-glutamate methylesterase activity
ISN32_RS12695	COG2198	Histidine kinase
ISN32_RS12695	COG0643	Histidine kinase
ISN32_RS12695	COG0784	Response regulator, receiver
ISN32_RS12700	COG0840	transmembrane signaling receptor activity
ISN32_RS12705	COG0835	chemotaxis
ISN32_RS12720	COG0189	ligase activity
ISN32_RS12745	COG1199	ATP-dependent helicase activity
ISN32_RS12755	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ISN32_RS12760	COG1216	Glycosyl transferase, family 2
ISN32_RS12770	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
ISN32_RS12790	COG4585	Histidine kinase
ISN32_RS12800	COG0850	regulation of cytokinetic process
ISN32_RS12805	COG2894	cell division
ISN32_RS12810	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
ISN32_RS12820	COG2205	protein histidine kinase activity
ISN32_RS12825	COG0745	RESPONSE REGULATOR receiver
ISN32_RS12835	COG2194	sulfuric ester hydrolase activity
ISN32_RS12880	COG2814	Major facilitator Superfamily
ISN32_RS12905	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ISN32_RS12905	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ISN32_RS12920	COG0753	catalase activity
ISN32_RS12945	COG1063	alcohol dehydrogenase
ISN32_RS12955	COG3459	Glycosyltransferase 36 associated
ISN32_RS13070	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ISN32_RS13080	COG0330	HflC and HflK could
ISN32_RS13085	COG0330	HflC and HflK could
ISN32_RS13090	COG0604	alcohol dehydrogenase
ISN32_RS13110	COG0678	peroxiredoxin activity
ISN32_RS13120	COG4953	penicillin-binding protein 1C
ISN32_RS13140	COG2373	Large extracellular alpha-helical protein
ISN32_RS13190	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ISN32_RS13210	COG0372	Belongs to the citrate synthase family
ISN32_RS13255	COG2161	toxin-antitoxin pair type II binding
ISN32_RS13260	COG4115	mRNA cleavage
ISN32_RS13280	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ISN32_RS13285	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ISN32_RS13290	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ISN32_RS13300	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ISN32_RS13305	COG1028	Short-chain dehydrogenase reductase Sdr
ISN32_RS13310	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ISN32_RS13315	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ISN32_RS13325	COG1399	metal-binding, possibly nucleic acid-binding protein
ISN32_RS13350	COG0714	Associated with various cellular activities
ISN32_RS13370	COG0537	adenosine 5'-monophosphoramidase activity
ISN32_RS13485	COG0314	molybdopterin synthase activity
ISN32_RS13490	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
ISN32_RS13495	COG0315	cyclic pyranopterin monophosphate synthase activity
ISN32_RS13505	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ISN32_RS13510	COG1234	tRNA 3'-trailer cleavage
ISN32_RS13520	COG0859	PFAM glycosyl transferase family 9
ISN32_RS13540	COG0631	protein serine/threonine phosphatase activity
ISN32_RS13545	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ISN32_RS13550	COG0328	RNA-DNA hybrid ribonuclease activity
ISN32_RS13560	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ISN32_RS13565	COG3942	CHAP domain
ISN32_RS13565	COG1388	LysM domain
ISN32_RS13600	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ISN32_RS13610	COG0544	peptidyl-prolyl cis-trans isomerase activity
ISN32_RS13655	COG0473	3-isopropylmalate dehydrogenase activity
ISN32_RS13670	COG4783	chaperone-mediated protein folding
ISN32_RS13685	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
ISN32_RS13690	COG0248	Ppx GppA phosphatase
ISN32_RS13695	COG0438	transferase activity, transferring glycosyl groups
ISN32_RS13705	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ISN32_RS13715	COG2833	Protein of unknown function (DUF455)
ISN32_RS13735	COG0285	dihydrofolate synthase activity
ISN32_RS13740	COG0588	phosphoglycerate mutase activity
ISN32_RS13760	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
ISN32_RS13765	COG4208	sulfate ABC transporter
ISN32_RS13770	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
ISN32_RS13775	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
ISN32_RS13780	COG0156	8-amino-7-oxononanoate synthase activity
ISN32_RS13785	COG1187	pseudouridine synthase activity
ISN32_RS13795	COG2885	chlorophyll binding
ISN32_RS13815	COG0667	Aldo Keto reductase
ISN32_RS13825	COG0446	pyridine nucleotide-disulphide oxidoreductase
ISN32_RS13825	COG1902	pentaerythritol trinitrate reductase activity
ISN32_RS13870	COG0625	glutathione transferase activity
ISN32_RS13885	COG0039	L-malate dehydrogenase activity
ISN32_RS13895	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ISN32_RS13900	COG1217	gtp-binding protein TYPA
ISN32_RS13915	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
ISN32_RS13925	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
ISN32_RS13930	COG0203	ribosomal protein L17
ISN32_RS13955	COG0201	protein transport
ISN32_RS13965	COG1841	ribosomal large subunit assembly
ISN32_RS13990	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ISN32_RS13995	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ISN32_RS14000	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
ISN32_RS14010	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ISN32_RS14015	COG0255	Belongs to the universal ribosomal protein uL29 family
ISN32_RS14040	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ISN32_RS14045	COG0089	rRNA binding
ISN32_RS14050	COG0088	Forms part of the polypeptide exit tunnel
ISN32_RS14060	COG0051	transcription antitermination factor activity, RNA binding
ISN32_RS14065	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ISN32_RS14070	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ISN32_RS14085	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ISN32_RS14095	COG0222	ribosome binding
ISN32_RS14110	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ISN32_RS14115	COG0250	Participates in transcription elongation, termination and antitermination
ISN32_RS14120	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ISN32_RS14130	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ISN32_RS14150	COG0012	GTP binding
ISN32_RS14155	COG0193	aminoacyl-tRNA hydrolase activity
ISN32_RS14165	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ISN32_RS14175	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ISN32_RS14190	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ISN32_RS14195	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ISN32_RS14250	COG0488	(ABC) transporter
ISN32_RS14320	COG3634	alkyl hydroperoxide reductase activity
ISN32_RS14325	COG0583	DNA-binding transcription factor activity
ISN32_RS14340	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ISN32_RS14370	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ISN32_RS14375	COG0697	spore germination
ISN32_RS14415	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ISN32_RS14420	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ISN32_RS14430	COG2096	Adenosyltransferase
ISN32_RS14440	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
ISN32_RS14445	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ISN32_RS14450	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
ISN32_RS14455	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ISN32_RS14460	COG2967	ApaG domain
ISN32_RS14465	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
ISN32_RS14500	COG1704	LemA family
ISN32_RS14505	COG0861	Integral membrane protein TerC family
ISN32_RS14510	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
ISN32_RS14520	COG0642	Histidine kinase
ISN32_RS14535	COG4181	ATPase activity
ISN32_RS14540	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
ISN32_RS14560	COG4771	TonB-dependent receptor
ISN32_RS14570	COG0667	Aldo Keto reductase
ISN32_RS14575	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ISN32_RS14595	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ISN32_RS14615	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ISN32_RS14680	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
ISN32_RS14690	COG0494	nUDIX hydrolase
ISN32_RS14705	COG0739	heme binding
ISN32_RS14715	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
ISN32_RS14720	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ISN32_RS14730	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
ISN32_RS14735	COG1181	Belongs to the D-alanine--D-alanine ligase family
ISN32_RS14760	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ISN32_RS14775	COG3116	cell division
ISN32_RS14780	COG0275	rRNA processing
ISN32_RS14785	COG2001	Belongs to the MraZ family
ISN32_RS14820	COG0792	nuclease activity
ISN32_RS14830	COG0277	FAD linked oxidase domain protein
ISN32_RS14835	COG0745	RESPONSE REGULATOR receiver
ISN32_RS14840	COG2205	protein histidine kinase activity
ISN32_RS14850	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
ISN32_RS14855	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
ISN32_RS14875	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
ISN32_RS14880	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ISN32_RS14885	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ISN32_RS14900	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ISN32_RS14900	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ISN32_RS14910	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ISN32_RS14930	COG0488	(ABC) transporter
ISN32_RS14935	COG0242	peptide deformylase activity
ISN32_RS14950	COG1960	acyl-CoA dehydrogenase activity
ISN32_RS14960	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ISN32_RS14970	COG1696	Membrane protein involved in D-alanine export
ISN32_RS14990	COG1215	transferase activity, transferring glycosyl groups
ISN32_RS15000	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ISN32_RS15050	COG2188	Transcriptional regulator
ISN32_RS15060	COG1450	Type ii and iii secretion system protein
ISN32_RS15075	COG3166	PFAM Fimbrial assembly family protein
ISN32_RS15080	COG3156	type II secretion system protein K
ISN32_RS15085	COG4795	General secretion pathway protein
ISN32_RS15090	COG2165	general secretion pathway protein
ISN32_RS15095	COG4970	Tfp pilus assembly protein FimT
ISN32_RS15100	COG2165	general secretion pathway protein
ISN32_RS15105	COG1459	type II secretion system
ISN32_RS15110	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ISN32_RS15115	COG1404	Belongs to the peptidase S8 family
ISN32_RS15120	COG5295	Hep Hag repeat protein
ISN32_RS15130	COG0840	transmembrane signaling receptor activity
ISN32_RS15135	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ISN32_RS15135	COG0047	phosphoribosylformylglycinamidine synthase activity
ISN32_RS15140	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ISN32_RS15145	COG4974	Belongs to the 'phage' integrase family
ISN32_RS15170	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ISN32_RS15175	COG2927	DNA polymerase III (CHI subunit)
ISN32_RS15210	COG1183	phosphatidylcholine synthase activity
ISN32_RS15220	COG0442	prolyl-tRNA aminoacylation
ISN32_RS15235	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ISN32_RS15240	COG1127	ABC transporter
ISN32_RS15245	COG3218	ABC-type transport auxiliary lipoprotein component
ISN32_RS15245	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ISN32_RS15275	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
ISN32_RS15280	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ISN32_RS15285	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
ISN32_RS15285	COG0662	Cupin 2, conserved barrel domain protein
ISN32_RS15310	COG2086	electron transfer activity
ISN32_RS15325	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
ISN32_RS15325	COG0546	phosphoglycolate phosphatase activity
ISN32_RS15330	COG0277	FAD linked oxidase domain protein
ISN32_RS15335	COG0300	oxidoreductase activity
ISN32_RS15340	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ISN32_RS15355	COG0493	'glutamate synthase
ISN32_RS15390	COG0438	transferase activity, transferring glycosyl groups
ISN32_RS15390	COG1216	Glycosyl transferase, family 2
ISN32_RS15395	COG0438	transferase activity, transferring glycosyl groups
ISN32_RS15395	COG1216	Glycosyl transferase, family 2
ISN32_RS15400	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ISN32_RS15415	COG0626	cystathionine gamma-synthase activity
ISN32_RS15445	COG0625	glutathione transferase activity
ISN32_RS15455	COG0513	Belongs to the DEAD box helicase family
ISN32_RS15460	COG0720	synthase
ISN32_RS15470	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
ISN32_RS15475	COG1956	GAF domain-containing protein
ISN32_RS15485	COG4206	TonB-dependent receptor
ISN32_RS15495	COG0546	phosphoglycolate phosphatase activity
ISN32_RS15520	COG0339	signal peptide processing
ISN32_RS15525	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ISN32_RS15535	COG2217	Heavy metal translocating P-type atpase
ISN32_RS15550	COG2132	Multicopper oxidase
ISN32_RS15565	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ISN32_RS15575	COG1136	(ABC) transporter
ISN32_RS15580	COG1136	(ABC) transporter
ISN32_RS15580	COG0577	efflux transmembrane transporter activity
ISN32_RS15585	COG1136	(ABC) transporter
ISN32_RS15585	COG0577	efflux transmembrane transporter activity
ISN32_RS15610	COG4191	Histidine kinase
ISN32_RS15620	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ISN32_RS15635	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ISN32_RS15650	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ISN32_RS15660	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ISN32_RS15670	COG0356	it plays a direct role in the translocation of protons across the membrane
ISN32_RS15685	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ISN32_RS15690	COG0508	dehydrogenase complex catalyzes the overall conversion of
ISN32_RS15725	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ISN32_RS15730	COG0697	spore germination
ISN32_RS15735	COG1666	GTP binding
ISN32_RS15745	COG1187	pseudouridine synthase activity
ISN32_RS15770	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISN32_RS15770	COG2205	protein histidine kinase activity
ISN32_RS15795	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ISN32_RS15860	COG0842	Transport permease protein
ISN32_RS15865	COG1131	(ABC) transporter
ISN32_RS15870	COG0025	NhaP-type Na H and K H
ISN32_RS15880	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
ISN32_RS15885	COG1573	uracil-dna glycosylase
ISN32_RS15895	COG3384	dioxygenase
ISN32_RS15920	COG0667	Aldo Keto reductase
ISN32_RS15930	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ISN32_RS15935	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ISN32_RS15960	COG2146	nitrite reductase [NAD(P)H] activity
ISN32_RS15965	COG3300	MHYT domain
ISN32_RS15965	COG5001	Diguanylate cyclase
ISN32_RS15995	COG4106	trans-aconitate 2-methyltransferase activity
ISN32_RS16005	COG2076	Multidrug Resistance protein
ISN32_RS16040	COG3275	phosphorelay sensor kinase activity
ISN32_RS16045	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
ISN32_RS16065	COG0531	amino acid
ISN32_RS16075	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
ISN32_RS16075	COG5297	Belongs to the glycosyl hydrolase family 6
ISN32_RS16090	COG0741	lytic transglycosylase activity
ISN32_RS16105	COG2207	Transcriptional regulator
ISN32_RS16115	COG0598	Magnesium transport protein CorA
ISN32_RS16120	COG1113	amino acid transport
ISN32_RS16125	COG0697	spore germination
ISN32_RS16150	COG2267	carboxylic ester hydrolase activity
ISN32_RS16230	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ISN32_RS16255	COG2353	YceI-like domain
ISN32_RS16280	COG0584	glycerophosphoryl diester phosphodiesterase
ISN32_RS16285	COG3547	Transposase (IS116 IS110 IS902 family)
ISN32_RS16300	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
ISN32_RS16325	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ISN32_RS16330	COG0459	protein refolding
ISN32_RS16340	COG1324	tolerance protein
ISN32_RS16350	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ISN32_RS16360	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
ISN32_RS16365	COG0511	ligase activity, forming carbon-carbon bonds
ISN32_RS16370	COG0439	Biotin carboxylase
ISN32_RS16385	COG2264	protein methyltransferase activity
ISN32_RS16405	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
ISN32_RS16410	COG4589	Belongs to the CDS family
ISN32_RS16430	COG2267	carboxylic ester hydrolase activity
ISN32_RS16435	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ISN32_RS16440	COG0138	bifunctional purine biosynthesis protein purh
ISN32_RS16445	COG0151	Belongs to the GarS family
ISN32_RS16450	COG1289	transmembrane transporter activity
ISN32_RS16455	COG2814	Major facilitator Superfamily
ISN32_RS16495	COG2816	NAD+ diphosphatase activity
ISN32_RS16540	COG2906	2 iron, 2 sulfur cluster binding
ISN32_RS16545	COG1051	belongs to the nudix hydrolase family
ISN32_RS16570	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
ISN32_RS16585	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
ISN32_RS16590	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ISN32_RS16595	COG0730	response to heat
ISN32_RS16605	COG0134	indole-3-glycerol-phosphate synthase activity
ISN32_RS16610	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ISN32_RS16640	COG1597	lipid kinase activity
ISN32_RS16655	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
ISN32_RS16670	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ISN32_RS16675	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ISN32_RS16675	COG2111	Na H antiporter
ISN32_RS16680	COG1006	Multisubunit Na H antiporter MnhC subunit
ISN32_RS16685	COG0651	ATP synthesis coupled electron transport
ISN32_RS16690	COG1863	multisubunit Na H antiporter MnhE subunit
ISN32_RS16695	COG2212	antiporter activity
ISN32_RS16700	COG1320	monovalent cation:proton antiporter activity
ISN32_RS16705	COG0530	calcium, potassium:sodium antiporter activity
ISN32_RS16750	COG0625	glutathione transferase activity
ISN32_RS16770	COG4555	ABC transporter
ISN32_RS16780	COG1476	TRANSCRIPTIONal
ISN32_RS16790	COG0543	2 iron, 2 sulfur cluster binding
ISN32_RS16790	COG0633	Ferredoxin
ISN32_RS16795	COG1131	(ABC) transporter
ISN32_RS16800	COG0842	Transport permease protein
ISN32_RS16840	COG0084	hydrolase, TatD family'
ISN32_RS16845	COG1643	Atp-dependent helicase
ISN32_RS16860	COG1187	pseudouridine synthase activity
ISN32_RS16875	COG2130	NADP-dependent
ISN32_RS16880	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ISN32_RS16910	COG0659	secondary active sulfate transmembrane transporter activity
ISN32_RS16945	COG2224	Isocitrate lyase
ISN32_RS16950	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
ISN32_RS16955	COG0583	DNA-binding transcription factor activity
ISN32_RS16975	COG0339	signal peptide processing
ISN32_RS16995	COG0564	pseudouridine synthase activity
ISN32_RS17000	COG4232	protein-disulfide reductase activity
ISN32_RS17015	COG1181	Belongs to the D-alanine--D-alanine ligase family
ISN32_RS17025	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ISN32_RS17040	COG0318	PFAM AMP-dependent synthetase and ligase
ISN32_RS17045	COG0727	PFAM Uncharacterised protein family (UPF0153)
ISN32_RS17055	COG0596	Alpha beta hydrolase
ISN32_RS17070	COG3177	Filamentation induced by cAMP protein fic
ISN32_RS17075	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ISN32_RS17085	COG0612	Peptidase, M16
ISN32_RS17095	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ISN32_RS17105	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ISN32_RS17110	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
ISN32_RS17150	COG0183	Belongs to the thiolase family
ISN32_RS17160	COG2032	superoxide dismutase activity
ISN32_RS17165	COG2032	superoxide dismutase activity
ISN32_RS17170	COG2204	response regulator
ISN32_RS17175	COG3852	Histidine kinase
ISN32_RS17180	COG0004	ammonium transporteR
ISN32_RS17185	COG0347	Belongs to the P(II) protein family
ISN32_RS17190	COG0174	glutamine synthetase
ISN32_RS17195	COG1968	undecaprenyl-diphosphatase activity
ISN32_RS17200	COG1881	PFAM PEBP family protein
ISN32_RS17210	COG2267	carboxylic ester hydrolase activity
ISN32_RS17220	COG2050	protein possibly involved in aromatic compounds catabolism
ISN32_RS17225	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ISN32_RS17235	COG2062	phosphohistidine phosphatase, SixA
ISN32_RS17280	COG2271	Major facilitator Superfamily
ISN32_RS17310	COG1111	helicase
ISN32_RS17310	COG1205	dead DEAH box helicase
ISN32_RS17355	COG0067	glutamate synthase
ISN32_RS17355	COG0069	glutamate synthase activity
ISN32_RS17355	COG0070	glutamate synthase
ISN32_RS17360	COG0493	'glutamate synthase
ISN32_RS17365	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
ISN32_RS17370	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
ISN32_RS17375	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
ISN32_RS17435	COG2951	lytic endotransglycosylase activity
ISN32_RS17450	COG0730	response to heat
ISN32_RS17475	COG0302	gtp cyclohydrolase
ISN32_RS17480	COG0477	Major facilitator Superfamily
ISN32_RS17530	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
ISN32_RS17540	COG1074	ATP-dependent DNA helicase activity
ISN32_RS17545	COG0537	adenosine 5'-monophosphoramidase activity
ISN32_RS17565	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ISN32_RS17570	COG1074	ATP-dependent DNA helicase activity
ISN32_RS17575	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
ISN32_RS17580	COG1127	ABC transporter
ISN32_RS17585	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ISN32_RS17590	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ISN32_RS17605	COG2853	Lipoprotein
ISN32_RS17610	COG0386	Belongs to the glutathione peroxidase family
ISN32_RS17615	COG1322	Protein conserved in bacteria
ISN32_RS17635	COG4191	Histidine kinase
ISN32_RS17640	COG4566	intracellular signal transduction
ISN32_RS17645	COG0531	amino acid
ISN32_RS17655	COG1929	Belongs to the glycerate kinase type-1 family
ISN32_RS17690	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ISN32_RS17705	COG0671	phosphoesterase, PA-phosphatase related
ISN32_RS17720	COG1752	Esterase of the alpha-beta hydrolase superfamily
ISN32_RS17755	COG1522	sequence-specific DNA binding
ISN32_RS17760	COG3186	Phenylalanine-4-hydroxylase
ISN32_RS17775	COG1028	Short-chain dehydrogenase reductase Sdr
ISN32_RS17780	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
ISN32_RS17790	COG1609	Transcriptional regulator
ISN32_RS17795	COG3507	Belongs to the glycosyl hydrolase 43 family
ISN32_RS17810	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ISN32_RS17855	COG4771	TonB-dependent receptor
ISN32_RS17875	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ISN32_RS17925	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISN32_RS17945	COG2186	Transcriptional regulator
ISN32_RS17950	COG1304	FMN binding
ISN32_RS17990	COG1012	belongs to the aldehyde dehydrogenase family
ISN32_RS17995	COG3284	Transcriptional regulator
ISN32_RS18005	COG4772	TonB-dependent receptor
ISN32_RS18020	COG1280	lysine exporter protein (LysE YggA)
ISN32_RS18035	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ISN32_RS18045	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
ISN32_RS18075	COG0501	Belongs to the peptidase M48B family
ISN32_RS18080	COG1266	CAAX protease self-immunity
ISN32_RS18085	COG0187	DNA topoisomerase II activity
ISN32_RS18090	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ISN32_RS18095	COG0592	DNA-directed DNA polymerase activity
ISN32_RS18110	COG0594	ribonuclease P activity
ISN32_RS18115	COG0706	membrane insertase activity
ISN32_RS18130	COG1119	ATPase activity
ISN32_RS18145	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ISN32_RS18160	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
ISN32_RS18170	COG1435	thymidine kinase activity
ISN32_RS18175	COG0210	DNA helicase
ISN32_RS18195	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ISN32_RS18200	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ISN32_RS18200	COG0519	Catalyzes the synthesis of GMP from XMP
ISN32_RS18210	COG0805	protein transport
ISN32_RS18220	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ISN32_RS18230	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ISN32_RS18250	COG0037	tRNA processing
ISN32_RS18255	COG2115	Belongs to the xylose isomerase family
ISN32_RS18265	COG3661	Belongs to the glycosyl hydrolase 67 family
ISN32_RS18275	COG4948	Mandelate Racemase Muconate Lactonizing
ISN32_RS18285	COG1472	Belongs to the glycosyl hydrolase 3 family
ISN32_RS18290	COG0246	Mannitol dehydrogenase
ISN32_RS18305	COG3386	PFAM SMP-30 Gluconolaconase
ISN32_RS18320	COG1904	glucuronate isomerase
ISN32_RS18325	COG3693	PFAM glycoside hydrolase, family 10
ISN32_RS18340	COG2211	Major facilitator Superfamily
ISN32_RS18365	COG2937	Belongs to the GPAT DAPAT family
ISN32_RS18375	COG1609	Transcriptional regulator
ISN32_RS18390	COG0284	orotidine-5'-phosphate decarboxylase activity
ISN32_RS18455	COG3132	Protein of unknown function, DUF480
ISN32_RS18475	COG0729	surface antigen
ISN32_RS18480	COG2911	Protein conserved in bacteria
ISN32_RS18495	COG3265	gluconokinase activity
ISN32_RS18500	COG2211	Major facilitator Superfamily
ISN32_RS18505	COG3459	Glycosyltransferase 36 associated
ISN32_RS18510	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ISN32_RS18520	COG2205	protein histidine kinase activity
ISN32_RS18525	COG1971	Probably functions as a manganese efflux pump
ISN32_RS18545	COG0477	Major facilitator Superfamily
ISN32_RS18570	COG2091	lysine biosynthetic process via aminoadipic acid
ISN32_RS18580	COG0357	Ribosomal RNA small subunit methyltransferase G
ISN32_RS18585	COG1192	Involved in chromosome partitioning
ISN32_RS18590	COG1475	DNA binding
ISN32_RS18600	COG0463	Glycosyl transferase, family 2
ISN32_RS18650	COG0210	DNA helicase
ISN32_RS18675	COG0589	response to stress
ISN32_RS18690	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ISN32_RS18690	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ISN32_RS18695	COG2323	membrane
ISN32_RS18705	COG0408	coproporphyrinogen oxidase activity
ISN32_RS18725	COG1271	oxidase subunit
ISN32_RS18730	COG1294	oxidase, subunit
ISN32_RS18755	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ISN32_RS18770	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ISN32_RS18805	COG0463	Glycosyl transferase, family 2
ISN32_RS18815	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ISN32_RS18820	COG3100	YcgL domain-containing protein
ISN32_RS18830	COG1404	Belongs to the peptidase S8 family
ISN32_RS18845	COG0745	RESPONSE REGULATOR receiver
ISN32_RS18850	COG3387	PFAM Glycoside hydrolase 15-related
ISN32_RS18855	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ISN32_RS18870	COG1278	Cold shock
ISN32_RS18890	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ISN32_RS18895	COG1960	acyl-CoA dehydrogenase activity
ISN32_RS18905	COG3245	cytochrome
ISN32_RS18915	COG1742	UPF0060 membrane protein
ISN32_RS18925	COG0523	cobalamin synthesis protein
ISN32_RS18930	COG0697	spore germination
ISN32_RS18940	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
ISN32_RS18945	COG1846	Transcriptional regulator
ISN32_RS18950	COG1764	response to oxidative stress
ISN32_RS18960	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ISN32_RS18965	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ISN32_RS18990	COG0583	DNA-binding transcription factor activity
ISN32_RS18995	COG2814	Major facilitator Superfamily
ISN32_RS19005	COG1902	pentaerythritol trinitrate reductase activity
ISN32_RS19010	COG2084	Dehydrogenase
ISN32_RS19035	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ISN32_RS19065	COG3228	Belongs to the MtfA family
ISN32_RS19075	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
ISN32_RS19075	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
ISN32_RS19080	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
ISN32_RS19115	COG0180	Tryptophanyl-tRNA synthetase
ISN32_RS19130	COG0697	spore germination
ISN32_RS19150	COG0577	efflux transmembrane transporter activity
ISN32_RS19155	COG1136	(ABC) transporter
ISN32_RS19180	COG0753	catalase activity
ISN32_RS19185	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ISN32_RS19190	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ISN32_RS19215	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ISN32_RS19300	COG1506	peptidase
ISN32_RS19300	COG0823	Involved in the tonB-independent uptake of proteins
ISN32_RS19315	COG4773	Receptor
ISN32_RS19335	COG4807	Protein conserved in bacteria
ISN32_RS19350	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ISN32_RS19380	COG1028	Short-chain dehydrogenase reductase Sdr
ISN32_RS19385	COG0179	Fumarylacetoacetate (FAA) hydrolase
ISN32_RS19390	COG4948	Mandelate Racemase Muconate Lactonizing
ISN32_RS19395	COG3254	rhamnose metabolic process
ISN32_RS19400	COG0738	Major facilitator superfamily
ISN32_RS19405	COG1414	Transcriptional regulator
ISN32_RS19450	COG1802	Transcriptional regulator
ISN32_RS19455	COG0477	Major facilitator Superfamily
ISN32_RS19470	COG1595	DNA-templated transcription, initiation
ISN32_RS19490	COG0604	alcohol dehydrogenase
ISN32_RS19490	COG1028	Short-chain dehydrogenase reductase Sdr
ISN32_RS19490	COG3321	synthase
ISN32_RS19500	COG1196	nuclear chromosome segregation
ISN32_RS19500	COG3264	Mechanosensitive ion channel
ISN32_RS19520	COG2354	Protein conserved in bacteria
ISN32_RS19550	COG0513	Belongs to the DEAD box helicase family
ISN32_RS19560	COG3227	Zinc metalloprotease (Elastase)
ISN32_RS19570	COG0508	dehydrogenase complex catalyzes the overall conversion of
ISN32_RS19585	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ISN32_RS19610	COG3104	oligopeptide transport
ISN32_RS19635	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
ISN32_RS19695	COG1199	ATP-dependent helicase activity
ISN32_RS19760	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ISN32_RS19780	COG0628	permease
ISN32_RS19790	COG2133	pyrroloquinoline quinone binding
ISN32_RS19835	COG0754	glutathionylspermidine amidase activity
ISN32_RS19845	COG0714	Associated with various cellular activities
ISN32_RS19890	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
ISN32_RS19905	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISN32_RS19910	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ISN32_RS19920	COG2203	Gaf domain
ISN32_RS19920	COG3706	GGDEF domain
ISN32_RS19920	COG4251	negative regulation of phosphorylation
ISN32_RS19920	COG5001	Diguanylate cyclase
ISN32_RS19935	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ISN32_RS19955	COG1028	Short-chain dehydrogenase reductase Sdr
ISN32_RS19970	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ISN32_RS19980	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ISN32_RS20015	COG0606	chelatase, subunit chli
ISN32_RS20020	COG2960	long-chain fatty acid transporting porin activity
ISN32_RS20035	COG1166	arginine decarboxylase activity
ISN32_RS20040	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ISN32_RS20045	COG1819	glycosyl
ISN32_RS20050	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
ISN32_RS20050	COG2755	lipolytic protein G-D-S-L family
ISN32_RS20055	COG0583	DNA-binding transcription factor activity
ISN32_RS20075	COG4221	oxidoreductase activity
ISN32_RS20095	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ISN32_RS20115	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ISN32_RS20125	COG2814	Major facilitator Superfamily
ISN32_RS20135	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
ISN32_RS20140	COG0739	heme binding
ISN32_RS20145	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)