locus-tag	class	description
NX81_RS00025	COG0187	DNA topoisomerase II activity
NX81_RS00035	COG0501	Belongs to the peptidase M48B family
NX81_RS00065	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
NX81_RS00075	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NX81_RS00125	COG0793	Belongs to the peptidase S41A family
NX81_RS00130	COG4942	peptidase
NX81_RS00140	COG2234	aminopeptidase activity
NX81_RS00150	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
NX81_RS00155	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
NX81_RS00160	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
NX81_RS00170	COG1064	alcohol dehydrogenase
NX81_RS00185	COG0493	'glutamate synthase
NX81_RS00190	COG0067	glutamate synthase
NX81_RS00190	COG0070	glutamate synthase
NX81_RS00190	COG0069	glutamate synthase activity
NX81_RS00275	COG1111	helicase
NX81_RS00275	COG1205	dead DEAH box helicase
NX81_RS00280	COG1272	protein, Hemolysin III
NX81_RS00325	COG2816	NAD+ diphosphatase activity
NX81_RS00330	COG0657	acetylesterase activity
NX81_RS00340	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NX81_RS00390	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
NX81_RS00410	COG4772	TonB-dependent receptor
NX81_RS00435	COG1304	FMN binding
NX81_RS00450	COG1755	Isoprenylcysteine carboxyl methyltransferase
NX81_RS00455	COG4585	Histidine kinase
NX81_RS00460	COG2197	response regulator
NX81_RS00530	COG3039	Transposase
NX81_RS00540	COG2831	hemolysin activation secretion protein
NX81_RS00550	COG0366	Alpha amylase catalytic
NX81_RS00555	COG0366	Alpha amylase catalytic
NX81_RS00580	COG0657	acetylesterase activity
NX81_RS00580	COG2755	lipolytic protein G-D-S-L family
NX81_RS00590	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
NX81_RS00605	COG3507	Belongs to the glycosyl hydrolase 43 family
NX81_RS00610	COG1609	Transcriptional regulator
NX81_RS00615	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
NX81_RS00620	COG1028	Short-chain dehydrogenase reductase Sdr
NX81_RS00630	COG2755	lipolytic protein G-D-S-L family
NX81_RS00640	COG3186	Phenylalanine-4-hydroxylase
NX81_RS00645	COG1522	sequence-specific DNA binding
NX81_RS00660	COG2951	lytic endotransglycosylase activity
NX81_RS00665	COG1752	Esterase of the alpha-beta hydrolase superfamily
NX81_RS00670	COG1473	amidohydrolase
NX81_RS00680	COG1119	ATPase activity
NX81_RS00695	COG1125	glycine betaine transport
NX81_RS00695	COG0517	IMP dehydrogenase activity
NX81_RS00710	COG1262	PFAM Formylglycine-generating sulfatase enzyme
NX81_RS00740	COG0489	protein tyrosine kinase activity
NX81_RS00745	COG2062	phosphohistidine phosphatase, SixA
NX81_RS00755	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NX81_RS00805	COG1968	undecaprenyl-diphosphatase activity
NX81_RS00810	COG0174	glutamine synthetase
NX81_RS00815	COG0347	Belongs to the P(II) protein family
NX81_RS00820	COG0004	ammonium transporteR
NX81_RS00825	COG3852	Histidine kinase
NX81_RS00830	COG2204	response regulator
NX81_RS00835	COG2032	superoxide dismutase activity
NX81_RS00840	COG2032	superoxide dismutase activity
NX81_RS00850	COG0346	lactoylglutathione lyase activity
NX81_RS00860	COG0183	Belongs to the thiolase family
NX81_RS00900	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NX81_RS00905	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
NX81_RS00910	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
NX81_RS00920	COG0028	Belongs to the TPP enzyme family
NX81_RS00925	COG2205	protein histidine kinase activity
NX81_RS00950	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
NX81_RS00965	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NX81_RS00970	COG3177	Filamentation induced by cAMP protein fic
NX81_RS00985	COG0596	Alpha beta hydrolase
NX81_RS00990	COG0727	PFAM Uncharacterised protein family (UPF0153)
NX81_RS00995	COG0318	PFAM AMP-dependent synthetase and ligase
NX81_RS01000	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NX81_RS01020	COG1181	Belongs to the D-alanine--D-alanine ligase family
NX81_RS01030	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
NX81_RS01035	COG4122	O-methyltransferase activity
NX81_RS01040	COG0564	pseudouridine synthase activity
NX81_RS01065	COG0339	signal peptide processing
NX81_RS01105	COG0583	DNA-binding transcription factor activity
NX81_RS01110	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
NX81_RS01115	COG2224	Isocitrate lyase
NX81_RS01145	COG4770	biotin carboxylase activity
NX81_RS01150	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NX81_RS01155	COG1960	acyl-CoA dehydrogenase activity
NX81_RS01210	COG0523	cobalamin synthesis protein
NX81_RS01220	COG0697	spore germination
NX81_RS01230	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
NX81_RS01240	COG1846	Transcriptional regulator
NX81_RS01245	COG1764	response to oxidative stress
NX81_RS01265	COG0656	L-ascorbic acid biosynthetic process
NX81_RS01270	COG2130	NADP-dependent
NX81_RS01285	COG1187	pseudouridine synthase activity
NX81_RS01295	COG1643	Atp-dependent helicase
NX81_RS01300	COG4807	Protein conserved in bacteria
NX81_RS01305	COG2351	hydroxyisourate hydrolase activity
NX81_RS01310	COG2072	flavoprotein involved in K transport
NX81_RS01330	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
NX81_RS01375	COG2252	PERMEase
NX81_RS01395	COG0084	hydrolase, TatD family'
NX81_RS01430	COG0583	DNA-binding transcription factor activity
NX81_RS01440	COG4221	oxidoreductase activity
NX81_RS01450	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
NX81_RS01455	COG1902	pentaerythritol trinitrate reductase activity
NX81_RS01480	COG0745	RESPONSE REGULATOR receiver
NX81_RS01500	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
NX81_RS01505	COG0583	DNA-binding transcription factor activity
NX81_RS01540	COG0702	epimerase
NX81_RS01545	COG1733	regulation of RNA biosynthetic process
NX81_RS01595	COG3039	Transposase
NX81_RS01620	COG0129	dihydroxy-acid dehydratase activity
NX81_RS01635	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
NX81_RS01690	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
NX81_RS01695	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
NX81_RS01725	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
NX81_RS01730	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
NX81_RS01740	COG3485	protocatechuate 3,4-dioxygenase
NX81_RS01745	COG3485	protocatechuate 3,4-dioxygenase
NX81_RS01760	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
NX81_RS01765	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NX81_RS01770	COG1414	Transcriptional regulator
NX81_RS01780	COG0657	acetylesterase activity
NX81_RS01785	COG0445	tRNA wobble uridine modification
NX81_RS01800	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
NX81_RS01845	COG0156	8-amino-7-oxononanoate synthase activity
NX81_RS01850	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
NX81_RS01855	COG1040	competence protein
NX81_RS01890	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
NX81_RS01985	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
NX81_RS02055	COG3264	Mechanosensitive ion channel
NX81_RS02055	COG1511	domain protein
NX81_RS02060	COG1368	sulfuric ester hydrolase activity
NX81_RS02070	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
NX81_RS02075	COG2354	Protein conserved in bacteria
NX81_RS02080	COG1649	PFAM Uncharacterised BCR, COG1649
NX81_RS02090	COG0297	glycogen (starch) synthase activity
NX81_RS02095	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
NX81_RS02100	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
NX81_RS02125	COG0702	epimerase
NX81_RS02130	COG1028	Short-chain dehydrogenase reductase Sdr
NX81_RS02155	COG0513	Belongs to the DEAD box helicase family
NX81_RS02170	COG0508	dehydrogenase complex catalyzes the overall conversion of
NX81_RS02185	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
NX81_RS02200	COG3483	tryptophan 2,3-dioxygenase activity
NX81_RS02205	COG3104	oligopeptide transport
NX81_RS02225	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
NX81_RS02265	COG1320	monovalent cation:proton antiporter activity
NX81_RS02270	COG2212	antiporter activity
NX81_RS02280	COG0651	ATP synthesis coupled electron transport
NX81_RS02285	COG1006	Multisubunit Na H antiporter MnhC subunit
NX81_RS02290	COG2111	Na H antiporter
NX81_RS02290	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
NX81_RS02340	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
NX81_RS02345	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
NX81_RS02355	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
NX81_RS02360	COG0456	acetyltransferase
NX81_RS02370	COG0582	viral genome integration into host DNA
NX81_RS02445	COG1597	lipid kinase activity
NX81_RS02475	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
NX81_RS02480	COG0134	indole-3-glycerol-phosphate synthase activity
NX81_RS02490	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NX81_RS02495	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
NX81_RS02505	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
NX81_RS02515	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
NX81_RS02550	COG0745	RESPONSE REGULATOR receiver
NX81_RS02570	COG0316	Belongs to the HesB IscA family
NX81_RS02585	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
NX81_RS02605	COG2814	Major facilitator Superfamily
NX81_RS02615	COG2814	Major facilitator Superfamily
NX81_RS02620	COG1289	transmembrane transporter activity
NX81_RS02625	COG0151	Belongs to the GarS family
NX81_RS02635	COG0138	bifunctional purine biosynthesis protein purh
NX81_RS02660	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
NX81_RS02705	COG0439	Biotin carboxylase
NX81_RS02715	COG0511	ligase activity, forming carbon-carbon bonds
NX81_RS02720	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
NX81_RS02730	COG1324	tolerance protein
NX81_RS02740	COG2356	endonuclease I
NX81_RS02755	COG0459	protein refolding
NX81_RS02780	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
NX81_RS02800	COG3386	PFAM SMP-30 Gluconolaconase
NX81_RS02810	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
NX81_RS02850	COG0778	Nitroreductase
NX81_RS02855	COG2353	YceI-like domain
NX81_RS02895	COG3052	prosthetic group binding
NX81_RS02930	COG1802	Transcriptional regulator
NX81_RS02995	COG3039	Transposase
NX81_RS03010	COG2963	transposase activity
NX81_RS03030	COG4221	oxidoreductase activity
NX81_RS03035	COG0435	Glutathione S-transferase
NX81_RS03085	COG3039	Transposase
NX81_RS03115	COG0697	spore germination
NX81_RS03130	COG4305	rare lipoprotein A
NX81_RS03145	COG1113	amino acid transport
NX81_RS03220	COG0840	transmembrane signaling receptor activity
NX81_RS03225	COG3039	Transposase
NX81_RS03230	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
NX81_RS03230	COG5297	Belongs to the glycosyl hydrolase family 6
NX81_RS03235	COG0659	secondary active sulfate transmembrane transporter activity
NX81_RS03260	COG2943	transferase activity, transferring hexosyl groups
NX81_RS03270	COG3275	phosphorelay sensor kinase activity
NX81_RS03280	COG0181	hydroxymethylbilane synthase activity
NX81_RS03310	COG1505	serine-type exopeptidase activity
NX81_RS03320	COG0436	Aminotransferase
NX81_RS03335	COG3039	Transposase
NX81_RS03390	COG0726	polysaccharide deacetylase
NX81_RS03390	COG1649	PFAM Uncharacterised BCR, COG1649
NX81_RS03395	COG1215	transferase activity, transferring glycosyl groups
NX81_RS03410	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
NX81_RS03415	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
NX81_RS03420	COG1609	Transcriptional regulator
NX81_RS03425	COG0738	Major facilitator superfamily
NX81_RS03430	COG2188	Transcriptional regulator
NX81_RS03445	COG3250	beta-galactosidase activity
NX81_RS03475	COG1028	Short-chain dehydrogenase reductase Sdr
NX81_RS03480	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
NX81_RS03485	COG4191	Histidine kinase
NX81_RS03490	COG0784	Response regulator, receiver
NX81_RS03495	COG4251	negative regulation of phosphorylation
NX81_RS03500	COG2823	Periplasmic or secreted lipoprotein
NX81_RS03505	COG0673	inositol 2-dehydrogenase activity
NX81_RS03515	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
NX81_RS03550	COG1056	cytidyltransferase-related domain
NX81_RS03550	COG1051	belongs to the nudix hydrolase family
NX81_RS03565	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
NX81_RS03570	COG0321	lipoyl(octanoyl) transferase activity
NX81_RS03575	COG2921	Belongs to the UPF0250 family
NX81_RS03585	COG1686	Belongs to the peptidase S11 family
NX81_RS03590	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
NX81_RS03595	COG2951	lytic endotransglycosylase activity
NX81_RS03625	COG3039	Transposase
NX81_RS03630	COG5297	Belongs to the glycosyl hydrolase family 6
NX81_RS03650	COG0772	Belongs to the SEDS family
NX81_RS03665	COG1792	Involved in formation and maintenance of cell shape
NX81_RS03670	COG1077	Cell shape determining protein MreB Mrl
NX81_RS03675	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NX81_RS03685	COG2801	Transposase and inactivated derivatives
NX81_RS03705	COG0028	Belongs to the TPP enzyme family
NX81_RS03705	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
NX81_RS03720	COG0367	asparagine synthase
NX81_RS03725	COG1012	belongs to the aldehyde dehydrogenase family
NX81_RS03730	COG0730	response to heat
NX81_RS03765	COG0308	aminopeptidase N
NX81_RS03770	COG5001	Diguanylate cyclase
NX81_RS03770	COG3300	MHYT domain
NX81_RS03780	COG2226	methyltransferase
NX81_RS03805	COG3039	Transposase
NX81_RS03810	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
NX81_RS03815	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
NX81_RS03825	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
NX81_RS03835	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
NX81_RS03845	COG2832	Protein of unknown function (DUF454)
NX81_RS03870	COG3039	Transposase
NX81_RS03880	COG0525	valine-tRNA ligase activity
NX81_RS03895	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
NX81_RS03905	COG0795	lipopolysaccharide-transporting ATPase activity
NX81_RS03915	COG4974	Belongs to the 'phage' integrase family
NX81_RS03920	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
NX81_RS03930	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
NX81_RS03930	COG0047	phosphoribosylformylglycinamidine synthase activity
NX81_RS03940	COG5295	Hep Hag repeat protein
NX81_RS03950	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
NX81_RS03960	COG1459	type II secretion system
NX81_RS03965	COG2165	general secretion pathway protein
NX81_RS03970	COG4970	Tfp pilus assembly protein FimT
NX81_RS03975	COG2165	general secretion pathway protein
NX81_RS03980	COG4795	General secretion pathway protein
NX81_RS03985	COG3156	type II secretion system protein K
NX81_RS03990	COG3166	PFAM Fimbrial assembly family protein
NX81_RS04005	COG1450	Type ii and iii secretion system protein
NX81_RS04020	COG2188	Transcriptional regulator
NX81_RS04065	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
NX81_RS04095	COG0242	peptide deformylase activity
NX81_RS04100	COG0488	(ABC) transporter
NX81_RS04125	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
NX81_RS04130	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
NX81_RS04140	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NX81_RS04140	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NX81_RS04160	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
NX81_RS04165	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
NX81_RS04170	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
NX81_RS04210	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
NX81_RS04215	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
NX81_RS04225	COG2205	protein histidine kinase activity
NX81_RS04230	COG0745	RESPONSE REGULATOR receiver
NX81_RS04235	COG0277	FAD linked oxidase domain protein
NX81_RS04240	COG1988	membrane-bound metal-dependent
NX81_RS04245	COG0792	nuclease activity
NX81_RS04295	COG3116	cell division
NX81_RS04310	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
NX81_RS04315	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NX81_RS04325	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
NX81_RS04330	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
NX81_RS04335	COG1181	Belongs to the D-alanine--D-alanine ligase family
NX81_RS04340	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
NX81_RS04355	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
NX81_RS04365	COG0739	heme binding
NX81_RS04370	COG0653	protein targeting
NX81_RS04375	COG0494	nUDIX hydrolase
NX81_RS04385	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
NX81_RS04395	COG0604	alcohol dehydrogenase
NX81_RS04395	COG3321	synthase
NX81_RS04395	COG1028	Short-chain dehydrogenase reductase Sdr
NX81_RS04445	COG2226	methyltransferase
NX81_RS04450	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
NX81_RS04460	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
NX81_RS04490	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
NX81_RS04500	COG4106	trans-aconitate 2-methyltransferase activity
NX81_RS04505	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
NX81_RS04520	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
NX81_RS04525	COG3039	Transposase
NX81_RS04535	COG3039	Transposase
NX81_RS04540	COG0667	Aldo Keto reductase
NX81_RS04555	COG4771	TonB-dependent receptor
NX81_RS04575	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NX81_RS04580	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
NX81_RS04590	COG2175	clavaminate synthase activity
NX81_RS04600	COG4181	ATPase activity
NX81_RS04615	COG0642	Histidine kinase
NX81_RS04630	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
NX81_RS04650	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
NX81_RS04665	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
NX81_RS04670	COG2967	ApaG domain
NX81_RS04675	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
NX81_RS04685	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
NX81_RS04695	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
NX81_RS04700	COG0123	including yeast histone deacetylase and acetoin utilization protein
NX81_RS04705	COG2096	Adenosyltransferase
NX81_RS04720	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NX81_RS04725	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NX81_RS04745	COG3384	dioxygenase
NX81_RS04750	COG0583	DNA-binding transcription factor activity
NX81_RS04755	COG0318	PFAM AMP-dependent synthetase and ligase
NX81_RS04765	COG1024	Enoyl-CoA hydratase
NX81_RS04785	COG3386	PFAM SMP-30 Gluconolaconase
NX81_RS04810	COG0697	spore germination
NX81_RS04820	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NX81_RS04850	COG2197	response regulator
NX81_RS04860	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NX81_RS04870	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
NX81_RS04875	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
NX81_RS04880	COG0583	DNA-binding transcription factor activity
NX81_RS04885	COG3634	alkyl hydroperoxide reductase activity
NX81_RS04895	COG2890	protein-(glutamine-N5) methyltransferase activity
NX81_RS04940	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NX81_RS04940	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NX81_RS04955	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
NX81_RS04980	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
NX81_RS05000	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NX81_RS05005	COG1404	Belongs to the peptidase S8 family
NX81_RS05010	COG1404	Belongs to the peptidase S8 family
NX81_RS05015	COG1404	Belongs to the peptidase S8 family
NX81_RS05020	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
NX81_RS05045	COG1295	ribonuclease BN
NX81_RS05050	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NX81_RS05070	COG0521	Mo-molybdopterin cofactor biosynthetic process
NX81_RS05080	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
NX81_RS05085	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
NX81_RS05095	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
NX81_RS05100	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
NX81_RS05110	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
NX81_RS05115	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
NX81_RS05120	COG0193	aminoacyl-tRNA hydrolase activity
NX81_RS05125	COG0012	GTP binding
NX81_RS05145	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
NX81_RS05155	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
NX81_RS05160	COG0250	Participates in transcription elongation, termination and antitermination
NX81_RS05165	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
NX81_RS05170	COG0081	regulation of translation
NX81_RS05175	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
NX81_RS05185	COG0085	RNA polymerase activity
NX81_RS05190	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
NX81_RS05195	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
NX81_RS05200	COG0049	tRNA binding
NX81_RS05205	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
NX81_RS05210	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
NX81_RS05225	COG0051	transcription antitermination factor activity, RNA binding
NX81_RS05235	COG0088	Forms part of the polypeptide exit tunnel
NX81_RS05245	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
NX81_RS05255	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
NX81_RS05265	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
NX81_RS05270	COG0255	Belongs to the universal ribosomal protein uL29 family
NX81_RS05275	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
NX81_RS05285	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
NX81_RS05320	COG1841	ribosomal large subunit assembly
NX81_RS05325	COG0200	Binds to the 23S rRNA
NX81_RS05330	COG0201	protein transport
NX81_RS05355	COG0203	ribosomal protein L17
NX81_RS05360	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
NX81_RS05370	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
NX81_RS05395	COG1217	gtp-binding protein TYPA
NX81_RS05400	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
NX81_RS05410	COG0625	glutathione transferase activity
NX81_RS05420	COG3039	Transposase
NX81_RS05435	COG0446	pyridine nucleotide-disulphide oxidoreductase
NX81_RS05435	COG1902	pentaerythritol trinitrate reductase activity
NX81_RS05440	COG0604	alcohol dehydrogenase
NX81_RS05445	COG2885	chlorophyll binding
NX81_RS05465	COG0156	8-amino-7-oxononanoate synthase activity
NX81_RS05470	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
NX81_RS05475	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
NX81_RS05480	COG4208	sulfate ABC transporter
NX81_RS05485	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
NX81_RS05515	COG0406	alpha-ribazole phosphatase activity
NX81_RS05525	COG0285	dihydrofolate synthase activity
NX81_RS05545	COG2833	Protein of unknown function (DUF455)
NX81_RS05550	COG3291	Pkd domain containing protein
NX81_RS05560	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NX81_RS05565	COG0671	phosphoesterase, PA-phosphatase related
NX81_RS05570	COG0438	transferase activity, transferring glycosyl groups
NX81_RS05580	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
NX81_RS05595	COG4783	chaperone-mediated protein folding
NX81_RS05615	COG0473	3-isopropylmalate dehydrogenase activity
NX81_RS05800	COG3039	Transposase
NX81_RS05845	COG3179	chitinase
NX81_RS05890	COG4695	Portal protein
NX81_RS05940	COG0544	peptidyl-prolyl cis-trans isomerase activity
NX81_RS05950	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
NX81_RS05980	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NX81_RS05995	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NX81_RS06010	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
NX81_RS06020	COG0631	protein serine/threonine phosphatase activity
NX81_RS06035	COG0859	PFAM glycosyl transferase family 9
NX81_RS06040	COG3642	lipopolysaccharide core region biosynthetic process
NX81_RS06045	COG1234	tRNA 3'-trailer cleavage
NX81_RS06050	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
NX81_RS06060	COG0315	cyclic pyranopterin monophosphate synthase activity
NX81_RS06065	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
NX81_RS06070	COG0314	molybdopterin synthase activity
NX81_RS06090	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
NX81_RS06100	COG0537	adenosine 5'-monophosphoramidase activity
NX81_RS06120	COG0714	Associated with various cellular activities
NX81_RS06130	COG3039	Transposase
NX81_RS06145	COG1399	metal-binding, possibly nucleic acid-binding protein
NX81_RS06155	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NX81_RS06170	COG1028	Short-chain dehydrogenase reductase Sdr
NX81_RS06175	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NX81_RS06185	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
NX81_RS06190	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
NX81_RS06210	COG4115	mRNA cleavage
NX81_RS06225	COG3829	transcription factor binding
NX81_RS06245	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
NX81_RS06275	COG2373	Large extracellular alpha-helical protein
NX81_RS06295	COG4953	penicillin-binding protein 1C
NX81_RS06305	COG0678	peroxiredoxin activity
NX81_RS06325	COG0330	HflC and HflK could
NX81_RS06330	COG0330	HflC and HflK could
NX81_RS06335	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
NX81_RS06340	COG0308	aminopeptidase N
NX81_RS06370	COG3039	Transposase
NX81_RS06390	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
NX81_RS06440	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
NX81_RS06455	COG3039	Transposase
NX81_RS06460	COG3387	PFAM Glycoside hydrolase 15-related
NX81_RS06465	COG1028	Short-chain dehydrogenase reductase Sdr
NX81_RS06485	COG3537	Alpha-1,2-mannosidase
NX81_RS06490	COG4221	oxidoreductase activity
NX81_RS06545	COG1529	Aldehyde oxidase and xanthine dehydrogenase
NX81_RS06550	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
NX81_RS06555	COG2080	2 iron, 2 sulfur cluster binding
NX81_RS06605	COG0587	DNA-directed DNA polymerase activity
NX81_RS06635	COG1297	OPT oligopeptide transporter protein
NX81_RS06645	COG3039	Transposase
NX81_RS06665	COG1506	peptidase
NX81_RS06665	COG0823	Involved in the tonB-independent uptake of proteins
NX81_RS06690	COG1917	Cupin 2, conserved barrel domain protein
NX81_RS06690	COG2207	Transcriptional regulator
NX81_RS06760	COG0753	catalase activity
NX81_RS06765	COG0656	L-ascorbic acid biosynthetic process
NX81_RS06770	COG2272	Belongs to the type-B carboxylesterase lipase family
NX81_RS06775	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NX81_RS06775	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NX81_RS06800	COG2814	Major facilitator Superfamily
NX81_RS06815	COG2194	sulfuric ester hydrolase activity
NX81_RS06830	COG0745	RESPONSE REGULATOR receiver
NX81_RS06835	COG0642	Histidine kinase
NX81_RS06845	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
NX81_RS06850	COG2894	cell division
NX81_RS06855	COG0850	regulation of cytokinetic process
NX81_RS06865	COG4585	Histidine kinase
NX81_RS06870	COG2197	response regulator
NX81_RS06885	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
NX81_RS06915	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
NX81_RS06930	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
NX81_RS06975	COG0488	(ABC) transporter
NX81_RS07025	COG0174	glutamine synthetase
NX81_RS07030	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
NX81_RS07040	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
NX81_RS07055	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
NX81_RS07070	COG3039	Transposase
NX81_RS07075	COG0477	Major facilitator Superfamily
NX81_RS07095	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
NX81_RS07115	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
NX81_RS07125	COG3158	transport of potassium into the cell
NX81_RS07130	COG2255	four-way junction helicase activity
NX81_RS07135	COG0824	Thioesterase
NX81_RS07145	COG0848	biopolymer transport protein
NX81_RS07155	COG0823	Involved in the tonB-independent uptake of proteins
NX81_RS07160	COG2885	chlorophyll binding
NX81_RS07170	COG0602	queuosine metabolic process
NX81_RS07180	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
NX81_RS07200	COG0840	transmembrane signaling receptor activity
NX81_RS07205	COG0840	transmembrane signaling receptor activity
NX81_RS07220	COG1187	pseudouridine synthase activity
NX81_RS07255	COG0514	ATP-dependent DNA helicase (RecQ)
NX81_RS07265	COG0783	Belongs to the Dps family
NX81_RS07270	COG1643	Atp-dependent helicase
NX81_RS07285	COG0837	glucose binding
NX81_RS07310	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
NX81_RS07315	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
NX81_RS07325	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NX81_RS07340	COG1215	transferase activity, transferring glycosyl groups
NX81_RS07350	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NX81_RS07360	COG1199	ATP-dependent helicase activity
NX81_RS07370	COG1397	ADP-ribosylglycohydrolase
NX81_RS07380	COG0189	ligase activity
NX81_RS07395	COG0835	chemotaxis
NX81_RS07400	COG0840	transmembrane signaling receptor activity
NX81_RS07405	COG0643	Histidine kinase
NX81_RS07405	COG2198	Histidine kinase
NX81_RS07405	COG0784	Response regulator, receiver
NX81_RS07440	COG1446	asparaginase
NX81_RS07445	COG3142	Participates in the control of copper homeostasis
NX81_RS07485	COG3537	Alpha-1,2-mannosidase
NX81_RS07535	COG1472	Belongs to the glycosyl hydrolase 3 family
NX81_RS07560	COG1388	LysM domain
NX81_RS07560	COG3858	chitin binding
NX81_RS07575	COG0837	glucose binding
NX81_RS07580	COG1385	rRNA (uridine-N3-)-methyltransferase activity
NX81_RS07590	COG0494	nUDIX hydrolase
NX81_RS07600	COG3956	TIGRFAM MazG family protein
NX81_RS07605	COG1742	UPF0060 membrane protein
NX81_RS07620	COG0404	The glycine cleavage system catalyzes the degradation of glycine
NX81_RS07625	COG0509	glycine decarboxylation via glycine cleavage system
NX81_RS07665	COG1960	acyl-CoA dehydrogenase activity
NX81_RS07675	COG1309	transcriptional regulator
NX81_RS07690	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
NX81_RS07700	COG0463	Glycosyl transferase, family 2
NX81_RS07710	COG2982	Protein involved in outer membrane biogenesis
NX81_RS07715	COG1272	protein, Hemolysin III
NX81_RS07720	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
NX81_RS07725	COG0739	heme binding
NX81_RS07730	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
NX81_RS07735	COG0626	cystathionine gamma-synthase activity
NX81_RS07740	COG0460	homoserine dehydrogenase
NX81_RS07740	COG0527	aspartate kinase activity
NX81_RS07750	COG1760	l-serine dehydratase
NX81_RS07780	COG2353	YceI-like domain
NX81_RS07785	COG2198	Histidine kinase
NX81_RS07785	COG2205	protein histidine kinase activity
NX81_RS07785	COG0784	Response regulator, receiver
NX81_RS07790	COG5002	protein histidine kinase activity
NX81_RS07790	COG0784	Response regulator, receiver
NX81_RS07805	COG2814	Major facilitator Superfamily
NX81_RS07810	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
NX81_RS07825	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
NX81_RS07830	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
NX81_RS07835	COG0259	pyridoxamine-phosphate oxidase activity
NX81_RS07845	COG1842	Phage shock protein A
NX81_RS07870	COG0754	glutathionylspermidine amidase activity
NX81_RS07880	COG2814	Major facilitator Superfamily
NX81_RS07950	COG0531	amino acid
NX81_RS07955	COG2197	response regulator
NX81_RS07975	COG1113	amino acid transport
NX81_RS07985	COG1271	oxidase subunit
NX81_RS07990	COG1294	oxidase, subunit
NX81_RS08005	COG2239	Acts as a magnesium transporter
NX81_RS08015	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NX81_RS08020	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
NX81_RS08030	COG1660	Displays ATPase and GTPase activities
NX81_RS08040	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NX81_RS08055	COG1137	ATPase activity
NX81_RS08060	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
NX81_RS08070	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
NX81_RS08080	COG0271	Belongs to the BolA IbaG family
NX81_RS08085	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
NX81_RS08105	COG3039	Transposase
NX81_RS08120	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
NX81_RS08130	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
NX81_RS08140	COG0628	permease
NX81_RS08150	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
NX81_RS08155	COG3178	'Phosphotransferase
NX81_RS08160	COG3039	Transposase
NX81_RS08170	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NX81_RS08175	COG1555	photosystem II stabilization
NX81_RS08185	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
NX81_RS08190	COG1477	protein flavinylation
NX81_RS08215	COG3128	pkhd-type hydroxylase
NX81_RS08220	COG4774	siderophore transport
NX81_RS08225	COG2146	nitrite reductase [NAD(P)H] activity
NX81_RS08240	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
NX81_RS08245	COG0719	Fe-S assembly protein
NX81_RS08250	COG0396	ATPase activity
NX81_RS08255	COG0719	Fe-S assembly protein
NX81_RS08260	COG1959	2 iron, 2 sulfur cluster binding
NX81_RS08270	COG0693	protein deglycase activity
NX81_RS08290	COG4942	peptidase
NX81_RS08305	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
NX81_RS08330	COG0519	Catalyzes the synthesis of GMP from XMP
NX81_RS08335	COG1678	Uncharacterized ACR, COG1678
NX81_RS08340	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
NX81_RS08345	COG0540	Belongs to the ATCase OTCase family
NX81_RS08355	COG1764	response to oxidative stress
NX81_RS08365	COG0384	phenazine biosynthesis protein PhzF
NX81_RS08370	COG0384	phenazine biosynthesis protein PhzF
NX81_RS08375	COG0527	aspartate kinase activity
NX81_RS08400	COG0142	geranyltranstransferase activity
NX81_RS08405	COG0629	single-stranded DNA binding
NX81_RS08410	COG3706	GGDEF domain
NX81_RS08410	COG5001	Diguanylate cyclase
NX81_RS08410	COG4251	negative regulation of phosphorylation
NX81_RS08410	COG2203	Gaf domain
NX81_RS08415	COG1028	Short-chain dehydrogenase reductase Sdr
NX81_RS08415	COG0604	alcohol dehydrogenase
NX81_RS08415	COG3321	synthase
NX81_RS08425	COG2080	2 iron, 2 sulfur cluster binding
NX81_RS08430	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
NX81_RS08435	COG1529	Aldehyde oxidase and xanthine dehydrogenase
NX81_RS08440	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
NX81_RS08475	COG2879	small protein
NX81_RS08480	COG1966	Carbon starvation protein
NX81_RS08485	COG1741	Belongs to the pirin family
NX81_RS08505	COG1741	Belongs to the pirin family
NX81_RS08520	COG0588	phosphoglycerate mutase activity
NX81_RS08530	COG3590	peptidase
NX81_RS08540	COG1566	PFAM secretion protein HlyD family protein
NX81_RS08545	COG1136	(ABC) transporter
NX81_RS08550	COG1136	(ABC) transporter
NX81_RS08550	COG0577	efflux transmembrane transporter activity
NX81_RS08565	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NX81_RS08575	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
NX81_RS08585	COG0835	chemotaxis
NX81_RS08590	COG0840	transmembrane signaling receptor activity
NX81_RS08600	COG0643	Histidine kinase
NX81_RS08600	COG2198	Histidine kinase
NX81_RS08675	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
NX81_RS08685	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
NX81_RS08690	COG0745	RESPONSE REGULATOR receiver
NX81_RS08700	COG2205	protein histidine kinase activity
NX81_RS08735	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NX81_RS08740	COG0735	belongs to the Fur family
NX81_RS08760	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NX81_RS08790	COG2207	Transcriptional regulator
NX81_RS08805	COG0583	DNA-binding transcription factor activity
NX81_RS08810	COG2814	Major facilitator Superfamily
NX81_RS08815	COG0667	Aldo Keto reductase
NX81_RS08920	COG5001	Diguanylate cyclase
NX81_RS08920	COG5002	protein histidine kinase activity
NX81_RS08925	COG1187	pseudouridine synthase activity
NX81_RS08955	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
NX81_RS08965	COG0475	glutathione-regulated potassium exporter activity
NX81_RS08970	COG5000	phosphorelay sensor kinase activity
NX81_RS08970	COG5002	protein histidine kinase activity
NX81_RS08975	COG0745	RESPONSE REGULATOR receiver
NX81_RS09005	COG1132	(ABC) transporter
NX81_RS09055	COG2155	Conserved Protein
NX81_RS09075	COG3118	belongs to the thioredoxin family
NX81_RS09105	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
NX81_RS09125	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
NX81_RS09140	COG2968	Membrane
NX81_RS09155	COG3164	Protein of unknown function
NX81_RS09165	COG0312	modulator of DNA gyrase
NX81_RS09175	COG0312	modulator of DNA gyrase
NX81_RS09185	COG4104	PAAR repeat-containing protein
NX81_RS09190	COG0142	geranyltranstransferase activity
NX81_RS09195	COG1722	exodeoxyribonuclease VII activity
NX81_RS09200	COG0037	tRNA processing
NX81_RS09205	COG1785	Belongs to the alkaline phosphatase family
NX81_RS09210	COG1301	dicarboxylic acid transport
NX81_RS09225	COG0791	NLP P60 protein
NX81_RS09230	COG0791	NLP P60 protein
NX81_RS09235	COG1047	Peptidyl-prolyl cis-trans
NX81_RS09240	COG2311	Membrane
NX81_RS09245	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NX81_RS09250	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NX81_RS09270	COG3590	peptidase
NX81_RS09275	COG3590	peptidase
NX81_RS09285	COG3039	Transposase
NX81_RS09300	COG0489	protein tyrosine kinase activity
NX81_RS09310	COG0717	Belongs to the dCTP deaminase family
NX81_RS09340	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NX81_RS09350	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
NX81_RS09380	COG0433	COG0433 Predicted ATPase
NX81_RS09395	COG0688	phosphatidylethanolamine metabolic process
NX81_RS09400	COG0688	phosphatidylethanolamine metabolic process
NX81_RS09410	COG2890	protein-(glutamine-N5) methyltransferase activity
NX81_RS09415	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
NX81_RS09420	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NX81_RS09425	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
NX81_RS09445	COG0101	tRNA pseudouridine synthase activity
NX81_RS09450	COG0135	phosphoribosylanthranilate isomerase activity
NX81_RS09460	COG0133	tryptophan synthase activity
NX81_RS09480	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
NX81_RS09485	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NX81_RS09535	COG0149	triose-phosphate isomerase activity
NX81_RS09550	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NX81_RS09560	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NX81_RS09565	COG0649	NAD binding
NX81_RS09570	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
NX81_RS09575	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
NX81_RS09580	COG1034	ATP synthesis coupled electron transport
NX81_RS09585	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
NX81_RS09590	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NX81_RS09615	COG1007	ATP synthesis coupled electron transport
NX81_RS09625	COG0779	Required for maturation of 30S ribosomal subunits
NX81_RS09630	COG0195	Participates in both transcription termination and antitermination
NX81_RS09635	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
NX81_RS09640	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
NX81_RS09650	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
NX81_RS09655	COG1185	polyribonucleotide nucleotidyltransferase activity
NX81_RS09690	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
NX81_RS09700	COG2095	MarC family integral membrane protein
NX81_RS09710	COG1611	Belongs to the LOG family
NX81_RS09715	COG3275	phosphorelay sensor kinase activity
NX81_RS09760	COG0556	nucleotide-excision repair
NX81_RS09775	COG3505	Type IV secretory pathway VirD4
NX81_RS09795	COG2948	multi-organism process
NX81_RS09815	COG3702	type iv secretory pathway
NX81_RS09850	COG3039	Transposase
NX81_RS09875	COG0504	CTP synthase activity
NX81_RS09895	COG0148	phosphopyruvate hydratase activity
NX81_RS09900	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
NX81_RS09910	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
NX81_RS09920	COG2840	Smr protein MutS2
NX81_RS09925	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
NX81_RS09930	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
NX81_RS09935	COG1238	metal cluster binding
NX81_RS09945	COG3737	Protein of unknown function (DUF498/DUF598)
NX81_RS09950	COG1534	Rna-binding protein
NX81_RS09955	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
NX81_RS09965	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
NX81_RS09970	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
NX81_RS09980	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
NX81_RS09985	COG1546	Belongs to the CinA family
NX81_RS10005	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
NX81_RS10010	COG2137	regulation of response to DNA damage stimulus
NX81_RS10015	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
NX81_RS10020	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
NX81_RS10040	COG1741	Belongs to the pirin family
NX81_RS10045	COG0583	DNA-binding transcription factor activity
NX81_RS10070	COG0352	thiamine-phosphate diphosphorylase activity
NX81_RS10070	COG0351	phosphomethylpyrimidine kinase
NX81_RS10085	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
NX81_RS10090	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
NX81_RS10105	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NX81_RS10115	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
NX81_RS10120	COG3734	2-keto-3-deoxy-galactonokinase
NX81_RS10130	COG4948	Mandelate Racemase Muconate Lactonizing
NX81_RS10135	COG0800	Aldolase
NX81_RS10195	COG1501	Belongs to the glycosyl hydrolase 31 family
NX81_RS10205	COG1070	Carbohydrate kinase
NX81_RS10215	COG0477	Major facilitator Superfamily
NX81_RS10225	COG3039	Transposase
NX81_RS10230	COG3039	Transposase
NX81_RS10255	COG1469	GTP cyclohydrolase I activity
NX81_RS10270	COG0617	tRNA 3'-terminal CCA addition
NX81_RS10280	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
NX81_RS10285	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
NX81_RS10290	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
NX81_RS10315	COG1472	Belongs to the glycosyl hydrolase 3 family
NX81_RS10340	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
NX81_RS10345	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
NX81_RS10355	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
NX81_RS10360	COG0671	phosphoesterase, PA-phosphatase related
NX81_RS10375	COG1794	racemase activity, acting on amino acids and derivatives
NX81_RS10385	COG0697	spore germination
NX81_RS10390	COG0812	UDP-N-acetylmuramate dehydrogenase activity
NX81_RS10410	COG1012	belongs to the aldehyde dehydrogenase family
NX81_RS10450	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
NX81_RS10460	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NX81_RS10465	COG0124	histidyl-tRNA synthetase
NX81_RS10475	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
NX81_RS10480	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
NX81_RS10485	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NX81_RS10490	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
NX81_RS10490	COG0131	Imidazoleglycerol-phosphate dehydratase
NX81_RS10495	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
NX81_RS10500	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
NX81_RS10505	COG0107	imidazoleglycerol-phosphate synthase activity
NX81_RS10510	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
NX81_RS10510	COG0140	phosphoribosyl-ATP diphosphatase activity
NX81_RS10535	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
NX81_RS10540	COG0235	Class ii aldolase
NX81_RS10545	COG0531	amino acid
NX81_RS10550	COG0531	amino acid
NX81_RS10560	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NX81_RS10565	COG0277	FAD linked oxidase domain protein
NX81_RS10585	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
NX81_RS10630	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NX81_RS10635	COG2258	MOSC domain
NX81_RS10645	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
NX81_RS10650	COG0505	Belongs to the CarA family
NX81_RS10660	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
NX81_RS10665	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
NX81_RS10675	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
NX81_RS10695	COG3279	Response regulator of the LytR AlgR family
NX81_RS10705	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
NX81_RS10715	COG2205	protein histidine kinase activity
NX81_RS10715	COG0784	Response regulator, receiver
NX81_RS10715	COG2198	Histidine kinase
NX81_RS10720	COG2198	Histidine kinase
NX81_RS10720	COG2205	protein histidine kinase activity
NX81_RS10720	COG0784	Response regulator, receiver
NX81_RS10725	COG1024	Enoyl-CoA hydratase
NX81_RS10730	COG0318	PFAM AMP-dependent synthetase and ligase
NX81_RS10760	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
NX81_RS10770	COG2201	protein-glutamate methylesterase activity
NX81_RS10785	COG0840	transmembrane signaling receptor activity
NX81_RS10795	COG0835	chemotaxis
NX81_RS10805	COG0840	transmembrane signaling receptor activity
NX81_RS10810	COG0840	transmembrane signaling receptor activity
NX81_RS10815	COG0840	transmembrane signaling receptor activity
NX81_RS10825	COG0840	transmembrane signaling receptor activity
NX81_RS10830	COG0840	transmembrane signaling receptor activity
NX81_RS10835	COG0840	transmembrane signaling receptor activity
NX81_RS10840	COG0840	transmembrane signaling receptor activity
NX81_RS10845	COG0840	transmembrane signaling receptor activity
NX81_RS10855	COG3039	Transposase
NX81_RS10860	COG0840	transmembrane signaling receptor activity
NX81_RS10875	COG0840	transmembrane signaling receptor activity
NX81_RS10880	COG0840	transmembrane signaling receptor activity
NX81_RS10890	COG0745	RESPONSE REGULATOR receiver
NX81_RS10900	COG0835	chemotaxis
NX81_RS10905	COG1192	Involved in chromosome partitioning
NX81_RS10910	COG1360	Flagellar Motor Protein
NX81_RS10915	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
NX81_RS11005	COG3039	Transposase
NX81_RS11025	COG0643	Histidine kinase
NX81_RS11025	COG0784	Response regulator, receiver
NX81_RS11025	COG2198	Histidine kinase
NX81_RS11085	COG1684	flagellar biosynthetic protein fliR
NX81_RS11105	COG3190	flagellar
NX81_RS11155	COG1677	Flagellar hook-basal body complex protein FliE
NX81_RS11185	COG1028	Short-chain dehydrogenase reductase Sdr
NX81_RS11190	COG1028	Short-chain dehydrogenase reductase Sdr
NX81_RS11195	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NX81_RS11215	COG2201	protein-glutamate methylesterase activity
NX81_RS11245	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
NX81_RS11250	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
NX81_RS11270	COG1706	bacterial-type flagellum-dependent cell motility
NX81_RS11275	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
NX81_RS11290	COG4787	bacterial-type flagellum-dependent cell motility
NX81_RS11300	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
NX81_RS11305	COG1558	bacterial-type flagellum-dependent cell motility
NX81_RS11315	COG0784	Response regulator, receiver
NX81_RS11315	COG0835	chemotaxis
NX81_RS11340	COG5002	protein histidine kinase activity
NX81_RS11350	COG4585	Histidine kinase
NX81_RS11380	COG0482	sulfurtransferase activity
NX81_RS11395	COG0542	response to heat
NX81_RS11405	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
NX81_RS11415	COG0492	ferredoxin-NADP+ reductase activity
NX81_RS11420	COG1674	ftsk spoiiie
NX81_RS11440	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
NX81_RS11445	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
NX81_RS11450	COG0183	Belongs to the thiolase family
NX81_RS11455	COG1250	3-hydroxyacyl-CoA dehydrogenase
NX81_RS11455	COG1024	Enoyl-CoA hydratase
NX81_RS11470	COG0820	rRNA (adenine-C2-)-methyltransferase activity
NX81_RS11490	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
NX81_RS11495	COG1160	GTP binding
NX81_RS11505	COG0303	'Molybdopterin
NX81_RS11510	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
NX81_RS11535	COG3039	Transposase
NX81_RS11560	COG0708	Exodeoxyribonuclease III
NX81_RS11570	COG0303	'Molybdopterin
NX81_RS11575	COG0746	molybdenum cofactor guanylyltransferase activity
NX81_RS11585	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
NX81_RS11585	COG1648	precorrin-2 dehydrogenase activity
NX81_RS11605	COG3685	Protein conserved in bacteria
NX81_RS11620	COG5001	Diguanylate cyclase
NX81_RS11630	COG4566	intracellular signal transduction
NX81_RS11690	COG2801	Transposase and inactivated derivatives
NX81_RS11785	COG0631	protein serine/threonine phosphatase activity
NX81_RS11790	COG0515	serine threonine protein kinase
NX81_RS11820	COG1858	cytochrome C peroxidase
NX81_RS11970	COG2154	pterin-4-alpha-carbinolamine dehydratase
NX81_RS11985	COG0428	transporter
NX81_RS11990	COG3064	Membrane
NX81_RS12000	COG1530	ribonuclease E activity
NX81_RS12015	COG1054	Belongs to the UPF0176 family
NX81_RS12035	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
NX81_RS12100	COG0629	single-stranded DNA binding
NX81_RS12105	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
NX81_RS12155	COG3039	Transposase
NX81_RS12160	COG1960	acyl-CoA dehydrogenase activity
NX81_RS12170	COG2816	NAD+ diphosphatase activity
NX81_RS12180	COG2814	Major facilitator Superfamily
NX81_RS12200	COG1028	Short-chain dehydrogenase reductase Sdr
NX81_RS12215	COG0583	DNA-binding transcription factor activity
NX81_RS12340	COG0583	DNA-binding transcription factor activity
NX81_RS12345	COG1396	sequence-specific DNA binding
NX81_RS12355	COG0582	viral genome integration into host DNA
NX81_RS12365	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
NX81_RS12370	COG0322	excinuclease ABC activity
NX81_RS12380	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NX81_RS12385	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
NX81_RS12390	COG1663	tetraacyldisaccharide 4'-kinase activity
NX81_RS12395	COG1132	(ABC) transporter
NX81_RS12405	COG0811	peptide transport
NX81_RS12425	COG4591	ABC-type transport system involved in lipoprotein release permease component
NX81_RS12435	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
NX81_RS12440	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
NX81_RS12455	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
NX81_RS12485	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
NX81_RS12490	COG0837	glucose binding
NX81_RS12495	COG0363	glucosamine-6-phosphate deaminase activity
NX81_RS12500	COG0129	dihydroxy-acid dehydratase activity
NX81_RS12505	COG0800	Aldolase
NX81_RS12575	COG2205	protein histidine kinase activity
NX81_RS12575	COG0784	Response regulator, receiver
NX81_RS12595	COG2183	response to ionizing radiation
NX81_RS12605	COG0723	plastoquinol--plastocyanin reductase activity
NX81_RS12605	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NX81_RS12620	COG3243	poly(R)-hydroxyalkanoic acid synthase
NX81_RS12630	COG1183	phosphatidylcholine synthase activity
NX81_RS12635	COG1028	Short-chain dehydrogenase reductase Sdr
NX81_RS12650	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
NX81_RS12660	COG0668	transmembrane transport
NX81_RS12665	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
NX81_RS12680	COG1914	H( )-stimulated, divalent metal cation uptake system
NX81_RS12695	COG2814	Major facilitator Superfamily
NX81_RS12705	COG3039	Transposase
NX81_RS12725	COG1335	isochorismatase
NX81_RS12740	COG4585	Histidine kinase
NX81_RS12745	COG2197	response regulator
NX81_RS12760	COG0583	DNA-binding transcription factor activity
NX81_RS12770	COG1028	Short-chain dehydrogenase reductase Sdr
NX81_RS12780	COG0583	DNA-binding transcription factor activity
NX81_RS12785	COG0583	DNA-binding transcription factor activity
NX81_RS12790	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
NX81_RS12795	COG3002	Belongs to the UPF0753 family
NX81_RS12810	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
NX81_RS12825	COG1210	Utp--glucose-1-phosphate uridylyltransferase
NX81_RS12840	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
NX81_RS12850	COG0776	regulation of translation
NX81_RS12855	COG0539	negative regulation of cytoplasmic translation
NX81_RS12860	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
NX81_RS12880	COG2957	Belongs to the agmatine deiminase family
NX81_RS12890	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NX81_RS12920	COG0395	ABC-type sugar transport system, permease component
NX81_RS12925	COG1175	transmembrane transport
NX81_RS12955	COG2350	Protein conserved in bacteria
NX81_RS12960	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
NX81_RS12965	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
NX81_RS12970	COG1187	pseudouridine synthase activity
NX81_RS12995	COG0436	Aminotransferase
NX81_RS13000	COG4133	protoheme IX ABC transporter activity
NX81_RS13020	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
NX81_RS13045	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
NX81_RS13050	COG1278	Cold shock
NX81_RS13060	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
NX81_RS13065	COG4988	ABC transporter
NX81_RS13100	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
NX81_RS13120	COG0165	Argininosuccinate lyase
NX81_RS13125	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
NX81_RS13135	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
NX81_RS13140	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NX81_RS13150	COG0137	argininosuccinate synthase activity
NX81_RS13155	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
NX81_RS13175	COG2166	iron-sulfur cluster assembly
NX81_RS13195	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
NX81_RS13245	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
NX81_RS13250	COG0402	S-adenosylhomocysteine deaminase activity
NX81_RS13265	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
NX81_RS13270	COG1509	lysine 2,3-aminomutase activity
NX81_RS13275	COG5001	Diguanylate cyclase
NX81_RS13275	COG3300	MHYT domain
NX81_RS13290	COG0483	inositol monophosphate 1-phosphatase activity
NX81_RS13295	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
NX81_RS13315	COG0488	(ABC) transporter
NX81_RS13320	COG0513	Belongs to the DEAD box helicase family
NX81_RS13325	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
NX81_RS13340	COG0625	glutathione transferase activity
NX81_RS13350	COG1671	Belongs to the UPF0178 family
NX81_RS13360	COG2081	HI0933 family
NX81_RS13370	COG0501	Belongs to the peptidase M48B family
NX81_RS13380	COG1028	Short-chain dehydrogenase reductase Sdr
NX81_RS13405	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
NX81_RS13410	COG0860	N-Acetylmuramoyl-L-alanine amidase
NX81_RS13415	COG0802	atpase or kinase
NX81_RS13420	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
NX81_RS13420	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
NX81_RS13430	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
NX81_RS13445	COG1262	PFAM Formylglycine-generating sulfatase enzyme
NX81_RS13490	COG0835	chemotaxis
NX81_RS13495	COG0840	transmembrane signaling receptor activity
NX81_RS13515	COG1201	RNA secondary structure unwinding
NX81_RS13520	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
NX81_RS13540	COG2969	positive regulation of protein catabolic process
NX81_RS13545	COG0625	glutathione transferase activity
NX81_RS13550	COG2857	Cytochrome c1
NX81_RS13555	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
NX81_RS13560	COG0723	plastoquinol--plastocyanin reductase activity
NX81_RS13565	COG0741	lytic transglycosylase activity
NX81_RS13585	COG1702	phosphate starvation-inducible protein PhoH
NX81_RS13610	COG4535	Mg2 and Co2 transporter CorC
NX81_RS13625	COG1012	belongs to the aldehyde dehydrogenase family
NX81_RS13630	COG1177	transmembrane transport
NX81_RS13635	COG1176	ABC-type spermidine putrescine transport system, permease component I
NX81_RS13640	COG3842	ATPase activity
NX81_RS13660	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
NX81_RS13675	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
NX81_RS13680	COG0174	glutamine synthetase
NX81_RS13685	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NX81_RS13695	COG0477	Major facilitator Superfamily
NX81_RS13710	COG0243	molybdopterin cofactor binding
NX81_RS13715	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
NX81_RS13720	COG2223	nitrite transmembrane transporter activity
NX81_RS13730	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
NX81_RS13735	COG1121	(ABC) transporter
NX81_RS13750	COG2733	membrane
NX81_RS13755	COG0784	Response regulator, receiver
NX81_RS13755	COG2205	protein histidine kinase activity
NX81_RS13755	COG5002	protein histidine kinase activity
NX81_RS13770	COG0477	Major facilitator Superfamily
NX81_RS13775	COG2902	Dehydrogenase
NX81_RS13785	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NX81_RS13790	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NX81_RS13825	COG1609	Transcriptional regulator
NX81_RS13830	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NX81_RS13830	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
NX81_RS13835	COG1105	Belongs to the carbohydrate kinase PfkB family
NX81_RS13840	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NX81_RS13840	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NX81_RS13870	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NX81_RS13880	COG1862	Preprotein translocase
NX81_RS13885	COG0343	queuine tRNA-ribosyltransferase activity
NX81_RS13890	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
NX81_RS13935	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
NX81_RS13940	COG3291	Pkd domain containing protein
NX81_RS13945	COG3039	Transposase
NX81_RS13960	COG0405	Gamma-glutamyltransferase
NX81_RS13965	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
NX81_RS13980	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
NX81_RS13985	COG0742	ribosomal rna small subunit methyltransferase
NX81_RS13990	COG0326	Molecular chaperone. Has ATPase activity
NX81_RS14015	COG4206	TonB-dependent receptor
NX81_RS14085	COG0531	amino acid
NX81_RS14100	COG0006	proline dipeptidase activity
NX81_RS14110	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NX81_RS14125	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NX81_RS14130	COG3938	Belongs to the proline racemase family
NX81_RS14140	COG0552	protein localization to endoplasmic reticulum
NX81_RS14160	COG4191	Histidine kinase
NX81_RS14160	COG0784	Response regulator, receiver
NX81_RS14170	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
NX81_RS14200	COG3040	lipid binding
NX81_RS14210	COG1960	acyl-CoA dehydrogenase activity
NX81_RS14220	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
NX81_RS14240	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NX81_RS14245	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NX81_RS14250	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NX81_RS14275	COG0438	transferase activity, transferring glycosyl groups
NX81_RS14285	COG0438	transferase activity, transferring glycosyl groups
NX81_RS14290	COG0438	transferase activity, transferring glycosyl groups
NX81_RS14345	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
NX81_RS14360	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
NX81_RS14365	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
NX81_RS14375	COG1434	Gram-negative-bacterium-type cell wall biogenesis
NX81_RS14380	COG0306	phosphate transporter
NX81_RS14395	COG1253	flavin adenine dinucleotide binding
NX81_RS14410	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NX81_RS14420	COG0477	Major facilitator Superfamily
NX81_RS14425	COG1132	(ABC) transporter
NX81_RS14430	COG1136	(ABC) transporter
NX81_RS14445	COG0438	transferase activity, transferring glycosyl groups
NX81_RS14485	COG2244	polysaccharide biosynthetic process
NX81_RS14555	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
NX81_RS14565	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
NX81_RS14575	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NX81_RS14590	COG0784	Response regulator, receiver
NX81_RS14590	COG4191	Histidine kinase
NX81_RS14595	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
NX81_RS14600	COG4191	Histidine kinase
NX81_RS14600	COG0784	Response regulator, receiver
NX81_RS14625	COG3039	Transposase
NX81_RS14630	COG0840	transmembrane signaling receptor activity
NX81_RS14675	COG2003	Belongs to the UPF0758 family
NX81_RS14765	COG0583	DNA-binding transcription factor activity
NX81_RS14770	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
NX81_RS14775	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
NX81_RS14790	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
NX81_RS14795	COG1605	Chorismate mutase
NX81_RS14795	COG0077	Prephenate dehydratase
NX81_RS14800	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
NX81_RS14805	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
NX81_RS14810	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
NX81_RS14850	COG1228	amidohydrolase
NX81_RS14855	COG2986	histidine ammonia-lyase
NX81_RS14865	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
NX81_RS14915	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
NX81_RS14930	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
NX81_RS14935	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
NX81_RS14940	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NX81_RS14950	COG3115	cell septum assembly
NX81_RS14970	COG0360	Binds together with S18 to 16S ribosomal RNA
NX81_RS14975	COG0316	Belongs to the HesB IscA family
NX81_RS14985	COG0017	Asparaginyl-tRNA synthetase
NX81_RS15010	COG0288	reversible hydration of carbon dioxide
NX81_RS15025	COG3844	kynureninase activity
NX81_RS15030	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NX81_RS15035	COG2925	Exonuclease
NX81_RS15045	COG0667	Aldo Keto reductase
NX81_RS15060	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
NX81_RS15065	COG0116	Belongs to the methyltransferase superfamily
NX81_RS15065	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
NX81_RS15075	COG0488	(ABC) transporter
NX81_RS15110	COG3039	Transposase
NX81_RS15120	COG0494	nUDIX hydrolase
NX81_RS15130	COG1024	Enoyl-CoA hydratase
NX81_RS15140	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
NX81_RS15145	COG0659	secondary active sulfate transmembrane transporter activity
NX81_RS15175	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
NX81_RS15180	COG0573	inorganic phosphate transmembrane transporter activity
NX81_RS15185	COG0581	inorganic phosphate transmembrane transporter activity
NX81_RS15190	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
NX81_RS15195	COG0704	Plays a role in the regulation of phosphate uptake
NX81_RS15205	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
NX81_RS15215	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NX81_RS15225	COG0557	exoribonuclease II activity
NX81_RS15255	COG1960	acyl-CoA dehydrogenase activity
NX81_RS15265	COG1410	methionine synthase
NX81_RS15265	COG0646	methionine synthase
NX81_RS15280	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NX81_RS15290	COG1609	Transcriptional regulator
NX81_RS15305	COG2900	Belongs to the SlyX family
NX81_RS15320	COG0386	Belongs to the glutathione peroxidase family
NX81_RS15330	COG1725	Transcriptional regulator
NX81_RS15335	COG1131	(ABC) transporter
NX81_RS15365	COG1253	flavin adenine dinucleotide binding
NX81_RS15400	COG2850	peptidyl-arginine hydroxylation
NX81_RS15435	COG1132	(ABC) transporter
NX81_RS15440	COG0583	DNA-binding transcription factor activity
NX81_RS15470	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
NX81_RS15475	COG0484	heat shock protein binding
NX81_RS15480	COG0443	Heat shock 70 kDa protein
NX81_RS15485	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
NX81_RS15490	COG1420	regulation of RNA biosynthetic process
NX81_RS15495	COG0497	DNA recombination
NX81_RS15505	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
NX81_RS15510	COG2914	Belongs to the UPF0125 (RnfH) family
NX81_RS15520	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
NX81_RS15535	COG0582	viral genome integration into host DNA
NX81_RS15750	COG0305	Participates in initiation and elongation during chromosome replication
NX81_RS15795	COG3039	Transposase
NX81_RS15820	COG3706	GGDEF domain
NX81_RS15865	COG0583	DNA-binding transcription factor activity
NX81_RS15875	COG0415	Belongs to the DNA photolyase family
NX81_RS15880	COG0305	Participates in initiation and elongation during chromosome replication
NX81_RS15890	COG0367	asparagine synthase
NX81_RS15910	COG1960	acyl-CoA dehydrogenase activity
NX81_RS15930	COG0084	hydrolase, TatD family'
NX81_RS15935	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
NX81_RS15995	COG0386	Belongs to the glutathione peroxidase family
NX81_RS16005	COG0339	signal peptide processing
NX81_RS16025	COG1595	DNA-templated transcription, initiation
NX81_RS16080	COG2814	Major facilitator Superfamily
NX81_RS16085	COG1566	PFAM secretion protein HlyD family protein
NX81_RS16100	COG2207	Transcriptional regulator
NX81_RS16115	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
NX81_RS16135	COG4774	siderophore transport
NX81_RS16145	COG0367	asparagine synthase
NX81_RS16150	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NX81_RS16160	COG1393	Belongs to the ArsC family
NX81_RS16175	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
NX81_RS16220	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
NX81_RS16225	COG3706	GGDEF domain
NX81_RS16230	COG0528	UMP kinase activity
NX81_RS16235	COG0233	cytoplasmic translational termination
NX81_RS16250	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
NX81_RS16255	COG0750	zinc metalloprotease
NX81_RS16265	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NX81_RS16270	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
NX81_RS16275	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NX81_RS16280	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NX81_RS16285	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
NX81_RS16300	COG0825	malonyl-CoA metabolic process
NX81_RS16320	COG1981	membrane
NX81_RS16360	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
NX81_RS16370	COG2040	homocysteine
NX81_RS16375	COG0833	amino acid
NX81_RS16380	COG0346	lactoylglutathione lyase activity
NX81_RS16390	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NX81_RS16390	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NX81_RS16400	COG2878	Part of a membrane complex involved in electron transport
NX81_RS16415	COG1595	DNA-templated transcription, initiation
NX81_RS16440	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
NX81_RS16455	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
NX81_RS16460	COG0251	oxidation-reduction process
NX81_RS16470	COG0392	lysyltransferase activity
NX81_RS16470	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
NX81_RS16505	COG2814	Major facilitator Superfamily
NX81_RS16510	COG1902	pentaerythritol trinitrate reductase activity
NX81_RS16555	COG1047	Peptidyl-prolyl cis-trans
NX81_RS16590	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
NX81_RS16600	COG5487	UPF0391 membrane protein
NX81_RS16610	COG1451	nucleotide metabolic process
NX81_RS16635	COG0183	Belongs to the thiolase family
NX81_RS16665	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
NX81_RS16665	COG1793	dna ligase
NX81_RS16675	COG1793	dna ligase
NX81_RS16680	COG1201	RNA secondary structure unwinding
NX81_RS16695	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NX81_RS16700	COG1278	Cold shock
NX81_RS16705	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
NX81_RS16710	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
NX81_RS16715	COG1472	Belongs to the glycosyl hydrolase 3 family
NX81_RS16720	COG3046	protein related to deoxyribodipyrimidine photolyase
NX81_RS16725	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
NX81_RS16730	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
NX81_RS16735	COG2954	triphosphatase activity
NX81_RS16750	COG1381	Involved in DNA repair and RecF pathway recombination
NX81_RS16755	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
NX81_RS16760	COG0571	ribonuclease III activity
NX81_RS16780	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NX81_RS16820	COG1024	Enoyl-CoA hydratase
NX81_RS16825	COG1960	acyl-CoA dehydrogenase activity
NX81_RS16845	COG3867	Arabinogalactan endo-beta-1,4-galactanase
NX81_RS16850	COG3250	beta-galactosidase activity
NX81_RS16875	COG3039	Transposase
NX81_RS16885	COG1028	Short-chain dehydrogenase reductase Sdr
NX81_RS16890	COG1028	Short-chain dehydrogenase reductase Sdr
NX81_RS16900	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
NX81_RS16920	COG0534	Mate efflux family protein
NX81_RS16930	COG0336	Belongs to the RNA methyltransferase TrmD family
NX81_RS16935	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
NX81_RS16940	COG0228	four-way junction DNA binding
NX81_RS16945	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NX81_RS16950	COG2070	2-Nitropropane dioxygenase
NX81_RS16960	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
NX81_RS16965	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
NX81_RS16980	COG3039	Transposase
NX81_RS16995	COG0784	Response regulator, receiver
NX81_RS16995	COG4191	Histidine kinase
NX81_RS17000	COG4999	Histidine kinase
NX81_RS17000	COG3850	Histidine kinase
NX81_RS17000	COG2205	protein histidine kinase activity
NX81_RS17000	COG3437	response regulator, receiver
NX81_RS17005	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
NX81_RS17015	COG2205	protein histidine kinase activity
NX81_RS17020	COG5507	3-demethylubiquinone-9 3-methyltransferase
NX81_RS17055	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
NX81_RS17060	COG1845	cytochrome c oxidase, subunit III
NX81_RS17065	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
NX81_RS17085	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
NX81_RS17090	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
NX81_RS17095	COG0196	riboflavin kinase activity
NX81_RS17100	COG0728	peptidoglycan biosynthetic process
NX81_RS17105	COG0268	Binds directly to 16S ribosomal RNA
NX81_RS17110	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
NX81_RS17115	COG0211	Belongs to the bacterial ribosomal protein bL27 family
NX81_RS17120	COG0261	This protein binds to 23S rRNA in the presence of protein L20
NX81_RS17125	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
NX81_RS17130	COG0824	Thioesterase
NX81_RS17145	COG1946	Acyl-CoA thioesterase
NX81_RS17170	COG4651	solute:proton antiporter activity
NX81_RS17170	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
NX81_RS17180	COG4772	TonB-dependent receptor
NX81_RS17190	COG4264	IucA IucC family
NX81_RS17195	COG2814	Major facilitator Superfamily
NX81_RS17205	COG0019	diaminopimelate decarboxylase activity
NX81_RS17235	COG3039	Transposase
NX81_RS17245	COG4206	TonB-dependent receptor
NX81_RS17255	COG0542	response to heat
NX81_RS17260	COG1116	anion transmembrane transporter activity
NX81_RS17265	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NX81_RS17270	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
NX81_RS17275	COG0667	Aldo Keto reductase
NX81_RS17280	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NX81_RS17285	COG4771	TonB-dependent receptor
NX81_RS17290	COG2827	Endonuclease containing a URI domain
NX81_RS17380	COG1877	trehalose-phosphatase activity
NX81_RS17385	COG3387	PFAM Glycoside hydrolase 15-related
NX81_RS17400	COG0840	transmembrane signaling receptor activity
NX81_RS17420	COG0564	pseudouridine synthase activity
NX81_RS17425	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
NX81_RS17430	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NX81_RS17430	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
NX81_RS17445	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
NX81_RS17450	COG0045	succinate-CoA ligase (ADP-forming) activity
NX81_RS17485	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
NX81_RS17495	COG3039	Transposase
NX81_RS17550	COG0745	RESPONSE REGULATOR receiver
NX81_RS17625	COG2022	thiamine diphosphate biosynthetic process
NX81_RS17630	COG0220	tRNA (guanine-N7-)-methyltransferase activity
NX81_RS17635	COG0471	metal ion transport
NX81_RS17635	COG3273	potassium ion transport
NX81_RS17655	COG1970	mechanosensitive ion channel activity
NX81_RS17665	COG1609	Transcriptional regulator
NX81_RS17690	COG3250	beta-galactosidase activity
NX81_RS17695	COG4948	Mandelate Racemase Muconate Lactonizing
NX81_RS17710	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NX81_RS17720	COG0308	aminopeptidase N
NX81_RS17770	COG2895	sulfate adenylyltransferase (ATP) activity
NX81_RS17770	COG0529	Catalyzes the synthesis of activated sulfate
NX81_RS17775	COG0175	sulfate reduction
NX81_RS17780	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
NX81_RS17785	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NX81_RS17790	COG0175	sulfate reduction
NX81_RS17810	COG2205	protein histidine kinase activity
NX81_RS17810	COG2198	Histidine kinase
NX81_RS17810	COG0784	Response regulator, receiver
NX81_RS17830	COG0583	DNA-binding transcription factor activity
NX81_RS17850	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
NX81_RS17855	COG3588	fructose-bisphosphate aldolase
NX81_RS17865	COG0469	pyruvate kinase activity
NX81_RS17900	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
NX81_RS17920	COG3047	cAMP biosynthetic process
NX81_RS17930	COG3453	Protein conserved in bacteria
NX81_RS17930	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NX81_RS17935	COG0725	ABC transporter, periplasmic molybdate-binding protein
NX81_RS17940	COG4149	molybdate abc transporter
NX81_RS17945	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
NX81_RS17965	COG1376	ErfK ybiS ycfS ynhG family protein
NX81_RS17970	COG0739	heme binding
NX81_RS17975	COG1028	Short-chain dehydrogenase reductase Sdr
NX81_RS17980	COG0583	DNA-binding transcription factor activity
NX81_RS17985	COG4773	Receptor
NX81_RS17995	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
NX81_RS18015	COG2304	oxidoreductase activity
NX81_RS18035	COG0714	Associated with various cellular activities
NX81_RS18070	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
NX81_RS18090	COG1957	nucleoside hydrolase
NX81_RS18095	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
NX81_RS18105	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NX81_RS18120	COG1561	YicC-like family, N-terminal region
NX81_RS18125	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
NX81_RS18140	COG0635	Involved in the biosynthesis of porphyrin-containing compound
NX81_RS18155	COG0006	proline dipeptidase activity
NX81_RS18165	COG0006	proline dipeptidase activity
NX81_RS18190	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
NX81_RS18210	COG2912	Transglutaminase-like superfamily
NX81_RS18215	COG1773	rubredoxin
NX81_RS18220	COG0352	thiamine-phosphate diphosphorylase activity
NX81_RS18240	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
NX81_RS18250	COG3039	Transposase
NX81_RS18260	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
NX81_RS18265	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NX81_RS18295	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NX81_RS18300	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NX81_RS18310	COG1028	Short-chain dehydrogenase reductase Sdr
NX81_RS18320	COG0671	phosphoesterase, PA-phosphatase related
NX81_RS18325	COG3781	membrane
NX81_RS18335	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
NX81_RS18355	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
NX81_RS18365	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
NX81_RS18385	COG3710	Transcriptional regulator
NX81_RS18390	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
NX81_RS18405	COG0840	transmembrane signaling receptor activity
NX81_RS18415	COG0405	Gamma-glutamyltransferase
NX81_RS18420	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
NX81_RS18440	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NX81_RS18445	COG0473	3-isopropylmalate dehydrogenase activity
NX81_RS18450	COG2226	methyltransferase
NX81_RS18455	COG0066	3-isopropylmalate dehydratase activity
NX81_RS18460	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
NX81_RS18485	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
NX81_RS18490	COG1538	Outer membrane efflux protein
NX81_RS18495	COG1519	Transferase
NX81_RS18500	COG1560	Kdo2-lipid A biosynthetic process
NX81_RS18615	COG0281	malic enzyme
NX81_RS18615	COG0280	phosphate acetyltransferase
NX81_RS18620	COG1301	dicarboxylic acid transport
NX81_RS18630	COG4191	Histidine kinase
NX81_RS18645	COG0583	DNA-binding transcription factor activity
NX81_RS18650	COG0667	Aldo Keto reductase
NX81_RS18670	COG2197	response regulator
NX81_RS18680	COG0642	Histidine kinase
NX81_RS18700	COG2851	Citrate transporter
NX81_RS18705	COG1028	Short-chain dehydrogenase reductase Sdr
NX81_RS18710	COG1609	Transcriptional regulator
NX81_RS18715	COG2211	Major facilitator Superfamily
NX81_RS18740	COG1162	GTPase activity
NX81_RS18745	COG0436	Aminotransferase
NX81_RS18765	COG0726	polysaccharide deacetylase
NX81_RS18770	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
NX81_RS18785	COG3964	amidohydrolase
NX81_RS18790	COG0402	S-adenosylhomocysteine deaminase activity
NX81_RS18850	COG3791	Glutathione-dependent formaldehyde-activating
NX81_RS18880	COG2205	protein histidine kinase activity
NX81_RS18905	COG0218	Necessary for normal cell division and for the maintenance of normal septation
NX81_RS18920	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
NX81_RS18940	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
NX81_RS18945	COG0456	acetyltransferase
NX81_RS18955	COG1183	phosphatidylcholine synthase activity
NX81_RS18965	COG0442	prolyl-tRNA aminoacylation
NX81_RS18980	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
NX81_RS18985	COG1127	ABC transporter
NX81_RS18990	COG3218	ABC-type transport auxiliary lipoprotein component
NX81_RS18990	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
NX81_RS19035	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NX81_RS19040	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
NX81_RS19040	COG0662	Cupin 2, conserved barrel domain protein
NX81_RS19065	COG2086	electron transfer activity
NX81_RS19080	COG3039	Transposase
NX81_RS19090	COG0546	phosphoglycolate phosphatase activity
NX81_RS19090	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
NX81_RS19095	COG0277	FAD linked oxidase domain protein
NX81_RS19135	COG0438	transferase activity, transferring glycosyl groups
NX81_RS19170	COG0626	cystathionine gamma-synthase activity
NX81_RS19200	COG0625	glutathione transferase activity
NX81_RS19215	COG0513	Belongs to the DEAD box helicase family
NX81_RS19225	COG0720	synthase
NX81_RS19235	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
NX81_RS19240	COG1956	GAF domain-containing protein
NX81_RS19255	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
NX81_RS19285	COG0339	signal peptide processing
NX81_RS19335	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
NX81_RS19340	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NX81_RS19345	COG1136	(ABC) transporter
NX81_RS19350	COG0577	efflux transmembrane transporter activity
NX81_RS19370	COG4191	Histidine kinase
NX81_RS19410	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
NX81_RS19415	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
NX81_RS19425	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
NX81_RS19430	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
NX81_RS19440	COG0356	it plays a direct role in the translocation of protons across the membrane
NX81_RS19460	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NX81_RS19470	COG0508	dehydrogenase complex catalyzes the overall conversion of
NX81_RS19520	COG2011	ABC-type metal ion transport system permease component
NX81_RS19525	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
NX81_RS19535	COG1666	GTP binding
NX81_RS19545	COG5002	protein histidine kinase activity
NX81_RS19545	COG2198	Histidine kinase
NX81_RS19545	COG0784	Response regulator, receiver
NX81_RS19565	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NX81_RS19570	COG1187	pseudouridine synthase activity
NX81_RS19575	COG2813	Specifically methylates the guanine in position
NX81_RS19605	COG2205	protein histidine kinase activity
NX81_RS19605	COG2202	Pas domain
NX81_RS19625	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
NX81_RS19630	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NX81_RS19675	COG0745	RESPONSE REGULATOR receiver
NX81_RS19690	COG1404	Belongs to the peptidase S8 family
NX81_RS19715	COG0842	Transport permease protein
NX81_RS19720	COG1131	(ABC) transporter
NX81_RS19725	COG0025	NhaP-type Na H and K H
NX81_RS19735	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
NX81_RS19740	COG1573	uracil-dna glycosylase
NX81_RS19755	COG3384	dioxygenase
NX81_RS19765	COG0583	DNA-binding transcription factor activity
NX81_RS19775	COG0667	Aldo Keto reductase
NX81_RS19785	COG3590	peptidase
NX81_RS19800	COG0531	amino acid
NX81_RS19815	COG2972	Histidine kinase
NX81_RS19840	COG3685	Protein conserved in bacteria
NX81_RS19845	COG3546	catalase activity
NX81_RS19895	COG1271	oxidase subunit
NX81_RS19900	COG1294	oxidase, subunit
NX81_RS19915	COG1028	Short-chain dehydrogenase reductase Sdr
NX81_RS19920	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
NX81_RS19940	COG1132	(ABC) transporter
NX81_RS19955	COG1063	alcohol dehydrogenase
NX81_RS20015	COG1131	(ABC) transporter
NX81_RS20055	COG0038	chloride channel
NX81_RS20065	COG0024	Methionine aminopeptidase
NX81_RS20095	COG3179	chitinase
NX81_RS20120	COG0860	N-Acetylmuramoyl-L-alanine amidase
NX81_RS20165	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NX81_RS20170	COG1490	D-aminoacyl-tRNA deacylase activity
NX81_RS20175	COG1560	Kdo2-lipid A biosynthetic process
NX81_RS20225	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
NX81_RS20225	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
NX81_RS20230	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
NX81_RS20235	COG0242	peptide deformylase activity
NX81_RS20240	COG1652	LysM domain
NX81_RS20245	COG0758	DNA mediated transformation
NX81_RS20265	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
NX81_RS20265	COG1754	DNA topoisomerase type I activity
NX81_RS20270	COG0009	L-threonylcarbamoyladenylate synthase
NX81_RS20285	COG1028	Short-chain dehydrogenase reductase Sdr
NX81_RS20295	COG0616	signal peptide processing
NX81_RS20300	COG0534	Mate efflux family protein
NX81_RS20320	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
NX81_RS20325	COG0625	glutathione transferase activity
NX81_RS20340	COG1252	NADH dehydrogenase
NX81_RS20345	COG2860	membrane
NX81_RS20350	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NX81_RS20355	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
NX81_RS20360	COG3437	response regulator, receiver
NX81_RS20365	COG2177	Part of the ABC transporter FtsEX involved in
NX81_RS20370	COG2884	Cell division ATP-binding protein ftsE
NX81_RS20380	COG3118	belongs to the thioredoxin family
NX81_RS20385	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
NX81_RS20395	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
NX81_RS20420	COG1652	LysM domain
NX81_RS20425	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
NX81_RS20425	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
NX81_RS20430	COG1473	amidohydrolase
NX81_RS20440	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NX81_RS20460	COG5383	Protein conserved in bacteria
NX81_RS20500	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
NX81_RS20505	COG3023	N-Acetylmuramoyl-L-alanine amidase
NX81_RS20515	COG4948	Mandelate Racemase Muconate Lactonizing
NX81_RS20530	COG0531	amino acid
NX81_RS20545	COG4682	membrane
NX81_RS20550	COG2133	pyrroloquinoline quinone binding
NX81_RS20560	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
NX81_RS20565	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
NX81_RS20575	COG1610	YqeY-like protein
NX81_RS20580	COG1295	ribonuclease BN
NX81_RS20585	COG0358	DNA primase activity
NX81_RS20630	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
NX81_RS20645	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
NX81_RS20695	COG0739	heme binding
NX81_RS20710	COG2211	Major facilitator Superfamily
NX81_RS20715	COG0708	Exodeoxyribonuclease III
NX81_RS20730	COG1192	Involved in chromosome partitioning
NX81_RS20735	COG1475	DNA binding
NX81_RS20755	COG0463	Glycosyl transferase, family 2
NX81_RS20780	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
NX81_RS20790	COG0018	arginyl-trna synthetase
NX81_RS20805	COG4221	oxidoreductase activity
NX81_RS20825	COG1166	arginine decarboxylase activity
NX81_RS20830	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
NX81_RS20870	COG0606	chelatase, subunit chli
NX81_RS20885	COG4943	cyclic-guanylate-specific phosphodiesterase activity
NX81_RS20910	COG1690	Belongs to the RtcB family
NX81_RS20955	COG1090	epimerase
NX81_RS20965	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NX81_RS20985	COG0628	permease
NX81_RS20990	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NX81_RS20995	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
NX81_RS21010	COG0753	catalase activity
NX81_RS21025	COG2197	response regulator
NX81_RS21030	COG3039	Transposase
NX81_RS21035	COG4585	Histidine kinase
NX81_RS21040	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NX81_RS21050	COG1136	(ABC) transporter
NX81_RS21075	COG0697	spore germination
NX81_RS21100	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NX81_RS21105	COG0180	Tryptophanyl-tRNA synthetase
NX81_RS21110	COG3237	CsbD-like
NX81_RS21155	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
NX81_RS21170	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
NX81_RS21175	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
NX81_RS21175	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
NX81_RS21220	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
NX81_RS21345	COG0740	serine-type endopeptidase activity
NX81_RS21545	COG1199	ATP-dependent helicase activity
NX81_RS21560	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
NX81_RS21575	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
NX81_RS21640	COG0625	glutathione transferase activity
NX81_RS21675	COG4555	ABC transporter
NX81_RS21690	COG1476	TRANSCRIPTIONal
NX81_RS21705	COG1230	cation diffusion facilitator family transporter
NX81_RS21710	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
NX81_RS21715	COG1131	(ABC) transporter
NX81_RS21720	COG0842	Transport permease protein
NX81_RS21730	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
NX81_RS21755	COG1607	acyl-coa hydrolase
NX81_RS21775	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NX81_RS21780	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NX81_RS21795	COG1042	CoA-binding domain protein
NX81_RS21795	COG0045	succinate-CoA ligase (ADP-forming) activity
NX81_RS21795	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NX81_RS21810	COG2239	Acts as a magnesium transporter
NX81_RS21825	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
NX81_RS21830	COG3387	PFAM Glycoside hydrolase 15-related
NX81_RS21845	COG3100	YcgL domain-containing protein
NX81_RS21850	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NX81_RS21860	COG0463	Glycosyl transferase, family 2
NX81_RS21880	COG1028	Short-chain dehydrogenase reductase Sdr
NX81_RS21905	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
NX81_RS21920	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NX81_RS21960	COG0408	coproporphyrinogen oxidase activity
NX81_RS21975	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
NX81_RS22060	COG0210	DNA helicase
NX81_RS22075	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NX81_RS22085	COG2159	amidohydrolase
NX81_RS22110	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NX81_RS22135	COG0357	Ribosomal RNA small subunit methyltransferase G
NX81_RS22150	COG2091	lysine biosynthetic process via aminoadipic acid
NX81_RS22165	COG0708	Exodeoxyribonuclease III
NX81_RS22170	COG1940	carbohydrate kinase activity
NX81_RS22180	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NX81_RS22190	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NX81_RS22195	COG3162	membrane
NX81_RS22260	COG1028	Short-chain dehydrogenase reductase Sdr
NX81_RS22265	COG0179	Fumarylacetoacetate (FAA) hydrolase
NX81_RS22270	COG4948	Mandelate Racemase Muconate Lactonizing
NX81_RS22275	COG3254	rhamnose metabolic process
NX81_RS22280	COG0738	Major facilitator superfamily
NX81_RS22285	COG1414	Transcriptional regulator
NX81_RS22300	COG2205	protein histidine kinase activity
NX81_RS22310	COG3459	Glycosyltransferase 36 associated
NX81_RS22315	COG2211	Major facilitator Superfamily
NX81_RS22320	COG3265	gluconokinase activity
NX81_RS22350	COG2911	Protein conserved in bacteria
NX81_RS22355	COG0729	surface antigen
NX81_RS22360	COG4771	TonB-dependent receptor
NX81_RS22365	COG0457	Tetratricopeptide repeat
NX81_RS22375	COG0752	glycyl-tRNA synthetase alpha subunit
NX81_RS22380	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
NX81_RS22395	COG0518	GMP synthase (glutamine-hydrolyzing) activity
NX81_RS22395	COG0519	Catalyzes the synthesis of GMP from XMP
NX81_RS22405	COG0805	protein transport
NX81_RS22410	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NX81_RS22415	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NX81_RS22425	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
NX81_RS22445	COG2974	May be involved in recombination
NX81_RS22450	COG0037	tRNA processing
NX81_RS22470	COG3661	Belongs to the glycosyl hydrolase 67 family
NX81_RS22480	COG4948	Mandelate Racemase Muconate Lactonizing
NX81_RS22490	COG1472	Belongs to the glycosyl hydrolase 3 family
NX81_RS22495	COG0246	Mannitol dehydrogenase
NX81_RS22555	COG3386	PFAM SMP-30 Gluconolaconase
NX81_RS22580	COG1904	glucuronate isomerase
NX81_RS22585	COG3693	PFAM glycoside hydrolase, family 10
NX81_RS22605	COG2211	Major facilitator Superfamily
NX81_RS22645	COG2937	Belongs to the GPAT DAPAT family
NX81_RS22675	COG0284	orotidine-5'-phosphate decarboxylase activity
NX81_RS22680	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
NX81_RS22685	COG3132	Protein of unknown function, DUF480
NX81_RS22700	COG0210	DNA helicase
NX81_RS22705	COG1435	thymidine kinase activity
NX81_RS22715	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
NX81_RS22725	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
NX81_RS22755	COG3135	benzoate transporter
NX81_RS22780	COG0676	glucose-6-phosphate 1-epimerase activity
NX81_RS22790	COG3012	SEC-C Motif Domain Protein
NX81_RS22795	COG0730	response to heat
NX81_RS22815	COG0302	gtp cyclohydrolase
NX81_RS22830	COG1566	PFAM secretion protein HlyD family protein
NX81_RS22840	COG1289	transmembrane transporter activity
NX81_RS22845	COG0477	Major facilitator Superfamily
NX81_RS22855	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NX81_RS22900	COG0564	pseudouridine synthase activity
NX81_RS22920	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
NX81_RS22975	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
NX81_RS22980	COG1074	ATP-dependent DNA helicase activity
NX81_RS22985	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
NX81_RS22990	COG1127	ABC transporter
NX81_RS22995	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
NX81_RS23000	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
NX81_RS23015	COG2853	Lipoprotein
NX81_RS23025	COG0386	Belongs to the glutathione peroxidase family
NX81_RS23040	COG1322	Protein conserved in bacteria
NX81_RS23045	COG0604	alcohol dehydrogenase
NX81_RS23075	COG0531	amino acid
NX81_RS23095	COG2199	diguanylate cyclase activity
NX81_RS23095	COG2203	Gaf domain
NX81_RS23100	COG3835	regulator
NX81_RS23105	COG1929	Belongs to the glycerate kinase type-1 family
NX81_RS23110	COG2271	Major facilitator Superfamily
NX81_RS23130	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
NX81_RS23140	COG0861	Integral membrane protein TerC family
NX81_RS23150	COG0584	glycerophosphoryl diester phosphodiesterase
NX81_RS23165	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
NX81_RS23175	COG0706	membrane insertase activity
NX81_RS23190	COG3118	belongs to the thioredoxin family
NX81_RS23220	COG2172	sigma factor antagonist activity
NX81_RS23225	COG1366	Belongs to the anti-sigma-factor antagonist family
NX81_RS23230	COG1366	Belongs to the anti-sigma-factor antagonist family
NX81_RS23240	COG0326	Molecular chaperone. Has ATPase activity
NX81_RS23245	COG2207	Transcriptional regulator
NX81_RS23260	COG3152	Membrane
NX81_RS23275	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
NX81_RS23280	COG1845	cytochrome c oxidase, subunit III
NX81_RS23285	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
NX81_RS23305	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
NX81_RS23515	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
NX81_RS23585	COG3504	Conjugal transfer protein
NX81_RS23590	COG2948	multi-organism process
NX81_RS23600	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
NX81_RS23605	COG1845	cytochrome c oxidase, subunit III
NX81_RS23610	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
NX81_RS23625	COG3152	Membrane
NX81_RS23640	COG2207	Transcriptional regulator