locus-tag	class	description
NX08_RS00025	COG0187	DNA topoisomerase II activity
NX08_RS00035	COG0501	Belongs to the peptidase M48B family
NX08_RS00065	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
NX08_RS00075	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NX08_RS00110	COG0793	Belongs to the peptidase S41A family
NX08_RS00115	COG4942	peptidase
NX08_RS00125	COG2234	aminopeptidase activity
NX08_RS00135	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
NX08_RS00150	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
NX08_RS00155	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
NX08_RS00165	COG1064	alcohol dehydrogenase
NX08_RS00180	COG0493	'glutamate synthase
NX08_RS00185	COG0069	glutamate synthase activity
NX08_RS00185	COG0070	glutamate synthase
NX08_RS00185	COG0067	glutamate synthase
NX08_RS00265	COG1205	dead DEAH box helicase
NX08_RS00265	COG1111	helicase
NX08_RS00270	COG1272	protein, Hemolysin III
NX08_RS00320	COG0657	acetylesterase activity
NX08_RS00330	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NX08_RS00340	COG0477	Major facilitator Superfamily
NX08_RS00375	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
NX08_RS00385	COG4772	TonB-dependent receptor
NX08_RS00410	COG1304	FMN binding
NX08_RS00510	COG0366	Alpha amylase catalytic
NX08_RS00515	COG0366	Alpha amylase catalytic
NX08_RS00520	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
NX08_RS00540	COG0657	acetylesterase activity
NX08_RS00540	COG2755	lipolytic protein G-D-S-L family
NX08_RS00570	COG1609	Transcriptional regulator
NX08_RS00575	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
NX08_RS00580	COG1028	Short-chain dehydrogenase reductase Sdr
NX08_RS00590	COG2755	lipolytic protein G-D-S-L family
NX08_RS00600	COG3186	Phenylalanine-4-hydroxylase
NX08_RS00605	COG1522	sequence-specific DNA binding
NX08_RS00625	COG1752	Esterase of the alpha-beta hydrolase superfamily
NX08_RS00630	COG1473	amidohydrolase
NX08_RS00640	COG1119	ATPase activity
NX08_RS00655	COG1125	glycine betaine transport
NX08_RS00655	COG0517	IMP dehydrogenase activity
NX08_RS00670	COG1262	PFAM Formylglycine-generating sulfatase enzyme
NX08_RS00710	COG0489	protein tyrosine kinase activity
NX08_RS00715	COG2062	phosphohistidine phosphatase, SixA
NX08_RS00725	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NX08_RS00775	COG1968	undecaprenyl-diphosphatase activity
NX08_RS00780	COG0174	glutamine synthetase
NX08_RS00785	COG0347	Belongs to the P(II) protein family
NX08_RS00790	COG0004	ammonium transporteR
NX08_RS00795	COG3852	Histidine kinase
NX08_RS00800	COG2204	response regulator
NX08_RS00805	COG2032	superoxide dismutase activity
NX08_RS00820	COG0346	lactoylglutathione lyase activity
NX08_RS00830	COG0183	Belongs to the thiolase family
NX08_RS00870	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NX08_RS00875	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
NX08_RS00880	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
NX08_RS00890	COG0028	Belongs to the TPP enzyme family
NX08_RS00895	COG2205	protein histidine kinase activity
NX08_RS00920	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
NX08_RS00935	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NX08_RS00940	COG3177	Filamentation induced by cAMP protein fic
NX08_RS00945	COG0596	Alpha beta hydrolase
NX08_RS00950	COG0727	PFAM Uncharacterised protein family (UPF0153)
NX08_RS00955	COG0318	PFAM AMP-dependent synthetase and ligase
NX08_RS00960	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NX08_RS00980	COG1181	Belongs to the D-alanine--D-alanine ligase family
NX08_RS00990	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
NX08_RS00995	COG4122	O-methyltransferase activity
NX08_RS01000	COG0564	pseudouridine synthase activity
NX08_RS01020	COG1446	asparaginase
NX08_RS01025	COG0339	signal peptide processing
NX08_RS01055	COG0475	glutathione-regulated potassium exporter activity
NX08_RS01060	COG0583	DNA-binding transcription factor activity
NX08_RS01065	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
NX08_RS01070	COG2224	Isocitrate lyase
NX08_RS01100	COG4770	biotin carboxylase activity
NX08_RS01105	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NX08_RS01110	COG1960	acyl-CoA dehydrogenase activity
NX08_RS01165	COG0523	cobalamin synthesis protein
NX08_RS01175	COG0697	spore germination
NX08_RS01185	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
NX08_RS01195	COG1846	Transcriptional regulator
NX08_RS01200	COG1764	response to oxidative stress
NX08_RS01220	COG0656	L-ascorbic acid biosynthetic process
NX08_RS01240	COG1187	pseudouridine synthase activity
NX08_RS01250	COG1643	Atp-dependent helicase
NX08_RS01255	COG4807	Protein conserved in bacteria
NX08_RS01260	COG2351	hydroxyisourate hydrolase activity
NX08_RS01285	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
NX08_RS01330	COG2252	PERMEase
NX08_RS01350	COG0084	hydrolase, TatD family'
NX08_RS01385	COG0583	DNA-binding transcription factor activity
NX08_RS01390	COG2814	Major facilitator Superfamily
NX08_RS01395	COG4221	oxidoreductase activity
NX08_RS01405	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
NX08_RS01410	COG1902	pentaerythritol trinitrate reductase activity
NX08_RS01435	COG0745	RESPONSE REGULATOR receiver
NX08_RS01455	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
NX08_RS01460	COG0583	DNA-binding transcription factor activity
NX08_RS01495	COG0702	epimerase
NX08_RS01500	COG1733	regulation of RNA biosynthetic process
NX08_RS01535	COG0129	dihydroxy-acid dehydratase activity
NX08_RS01550	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
NX08_RS01605	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
NX08_RS01610	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
NX08_RS01635	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
NX08_RS01640	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
NX08_RS01650	COG3485	protocatechuate 3,4-dioxygenase
NX08_RS01655	COG3485	protocatechuate 3,4-dioxygenase
NX08_RS01665	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
NX08_RS01670	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NX08_RS01675	COG1414	Transcriptional regulator
NX08_RS01685	COG0657	acetylesterase activity
NX08_RS01690	COG0445	tRNA wobble uridine modification
NX08_RS01700	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
NX08_RS01745	COG0156	8-amino-7-oxononanoate synthase activity
NX08_RS01750	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
NX08_RS01755	COG1040	competence protein
NX08_RS01790	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
NX08_RS01875	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
NX08_RS01950	COG1511	domain protein
NX08_RS01950	COG3264	Mechanosensitive ion channel
NX08_RS01955	COG1368	sulfuric ester hydrolase activity
NX08_RS01965	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
NX08_RS01970	COG2354	Protein conserved in bacteria
NX08_RS01975	COG1649	PFAM Uncharacterised BCR, COG1649
NX08_RS01985	COG0297	glycogen (starch) synthase activity
NX08_RS01990	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
NX08_RS01995	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
NX08_RS02065	COG0508	dehydrogenase complex catalyzes the overall conversion of
NX08_RS02080	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
NX08_RS02095	COG3483	tryptophan 2,3-dioxygenase activity
NX08_RS02105	COG3104	oligopeptide transport
NX08_RS02125	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
NX08_RS02165	COG1320	monovalent cation:proton antiporter activity
NX08_RS02170	COG2212	antiporter activity
NX08_RS02180	COG0651	ATP synthesis coupled electron transport
NX08_RS02185	COG1006	Multisubunit Na H antiporter MnhC subunit
NX08_RS02190	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
NX08_RS02190	COG2111	Na H antiporter
NX08_RS02255	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
NX08_RS02260	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
NX08_RS02270	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
NX08_RS02275	COG0456	acetyltransferase
NX08_RS02280	COG1597	lipid kinase activity
NX08_RS02315	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
NX08_RS02320	COG0134	indole-3-glycerol-phosphate synthase activity
NX08_RS02330	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NX08_RS02335	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
NX08_RS02345	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
NX08_RS02355	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
NX08_RS02390	COG0745	RESPONSE REGULATOR receiver
NX08_RS02410	COG0316	Belongs to the HesB IscA family
NX08_RS02425	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
NX08_RS02445	COG2814	Major facilitator Superfamily
NX08_RS02455	COG2814	Major facilitator Superfamily
NX08_RS02460	COG1289	transmembrane transporter activity
NX08_RS02465	COG0151	Belongs to the GarS family
NX08_RS02475	COG0419	ATPase involved in DNA repair
NX08_RS02480	COG0138	bifunctional purine biosynthesis protein purh
NX08_RS02505	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
NX08_RS02555	COG0439	Biotin carboxylase
NX08_RS02565	COG0511	ligase activity, forming carbon-carbon bonds
NX08_RS02570	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
NX08_RS02580	COG1324	tolerance protein
NX08_RS02590	COG2356	endonuclease I
NX08_RS02605	COG0459	protein refolding
NX08_RS02630	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
NX08_RS02650	COG3386	PFAM SMP-30 Gluconolaconase
NX08_RS02660	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
NX08_RS02700	COG0778	Nitroreductase
NX08_RS02705	COG2353	YceI-like domain
NX08_RS02745	COG3052	prosthetic group binding
NX08_RS02780	COG1802	Transcriptional regulator
NX08_RS02785	COG0546	phosphoglycolate phosphatase activity
NX08_RS02835	COG2176	DNA-directed DNA polymerase activity
NX08_RS02900	COG4221	oxidoreductase activity
NX08_RS02905	COG0435	Glutathione S-transferase
NX08_RS02980	COG0697	spore germination
NX08_RS03000	COG4305	rare lipoprotein A
NX08_RS03010	COG1113	amino acid transport
NX08_RS03075	COG5001	Diguanylate cyclase
NX08_RS03085	COG5297	Belongs to the glycosyl hydrolase family 6
NX08_RS03085	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
NX08_RS03090	COG0659	secondary active sulfate transmembrane transporter activity
NX08_RS03115	COG2943	transferase activity, transferring hexosyl groups
NX08_RS03125	COG3275	phosphorelay sensor kinase activity
NX08_RS03135	COG0181	hydroxymethylbilane synthase activity
NX08_RS03165	COG1505	serine-type exopeptidase activity
NX08_RS03175	COG0436	Aminotransferase
NX08_RS03190	COG2832	Protein of unknown function (DUF454)
NX08_RS03200	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
NX08_RS03210	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
NX08_RS03220	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
NX08_RS03225	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
NX08_RS03250	COG2226	methyltransferase
NX08_RS03260	COG5001	Diguanylate cyclase
NX08_RS03260	COG3300	MHYT domain
NX08_RS03265	COG0308	aminopeptidase N
NX08_RS03300	COG0730	response to heat
NX08_RS03305	COG1012	belongs to the aldehyde dehydrogenase family
NX08_RS03310	COG0367	asparagine synthase
NX08_RS03325	COG0028	Belongs to the TPP enzyme family
NX08_RS03325	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
NX08_RS03355	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NX08_RS03360	COG1077	Cell shape determining protein MreB Mrl
NX08_RS03365	COG1792	Involved in formation and maintenance of cell shape
NX08_RS03380	COG0772	Belongs to the SEDS family
NX08_RS03395	COG5297	Belongs to the glycosyl hydrolase family 6
NX08_RS03430	COG2951	lytic endotransglycosylase activity
NX08_RS03435	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
NX08_RS03440	COG1686	Belongs to the peptidase S11 family
NX08_RS03450	COG2921	Belongs to the UPF0250 family
NX08_RS03455	COG0321	lipoyl(octanoyl) transferase activity
NX08_RS03460	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
NX08_RS03475	COG1056	cytidyltransferase-related domain
NX08_RS03475	COG1051	belongs to the nudix hydrolase family
NX08_RS03510	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
NX08_RS03520	COG0673	inositol 2-dehydrogenase activity
NX08_RS03525	COG2823	Periplasmic or secreted lipoprotein
NX08_RS03530	COG4251	negative regulation of phosphorylation
NX08_RS03535	COG0784	Response regulator, receiver
NX08_RS03540	COG4191	Histidine kinase
NX08_RS03545	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
NX08_RS03550	COG1028	Short-chain dehydrogenase reductase Sdr
NX08_RS03580	COG3250	beta-galactosidase activity
NX08_RS03595	COG2188	Transcriptional regulator
NX08_RS03605	COG1609	Transcriptional regulator
NX08_RS03610	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
NX08_RS03615	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
NX08_RS03630	COG1215	transferase activity, transferring glycosyl groups
NX08_RS03635	COG1649	PFAM Uncharacterised BCR, COG1649
NX08_RS03635	COG0726	polysaccharide deacetylase
NX08_RS03660	COG4206	TonB-dependent receptor
NX08_RS03705	COG0525	valine-tRNA ligase activity
NX08_RS03720	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
NX08_RS03730	COG0795	lipopolysaccharide-transporting ATPase activity
NX08_RS03740	COG4974	Belongs to the 'phage' integrase family
NX08_RS03745	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
NX08_RS03760	COG0047	phosphoribosylformylglycinamidine synthase activity
NX08_RS03760	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
NX08_RS03770	COG5295	Hep Hag repeat protein
NX08_RS03785	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
NX08_RS03795	COG1459	type II secretion system
NX08_RS03800	COG2165	general secretion pathway protein
NX08_RS03805	COG4970	Tfp pilus assembly protein FimT
NX08_RS03810	COG2165	general secretion pathway protein
NX08_RS03815	COG4795	General secretion pathway protein
NX08_RS03820	COG3156	type II secretion system protein K
NX08_RS03825	COG3166	PFAM Fimbrial assembly family protein
NX08_RS03840	COG1450	Type ii and iii secretion system protein
NX08_RS03850	COG2188	Transcriptional regulator
NX08_RS03905	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
NX08_RS03935	COG0242	peptide deformylase activity
NX08_RS03940	COG0488	(ABC) transporter
NX08_RS03965	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
NX08_RS03970	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
NX08_RS03980	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NX08_RS03980	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NX08_RS04000	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
NX08_RS04005	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
NX08_RS04010	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
NX08_RS04050	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
NX08_RS04055	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
NX08_RS04065	COG2205	protein histidine kinase activity
NX08_RS04070	COG0745	RESPONSE REGULATOR receiver
NX08_RS04075	COG0277	FAD linked oxidase domain protein
NX08_RS04080	COG1988	membrane-bound metal-dependent
NX08_RS04085	COG0792	nuclease activity
NX08_RS04130	COG0275	rRNA processing
NX08_RS04135	COG3116	cell division
NX08_RS04150	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
NX08_RS04155	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NX08_RS04165	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
NX08_RS04170	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
NX08_RS04175	COG1181	Belongs to the D-alanine--D-alanine ligase family
NX08_RS04180	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
NX08_RS04195	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
NX08_RS04205	COG0739	heme binding
NX08_RS04210	COG0653	protein targeting
NX08_RS04215	COG0494	nUDIX hydrolase
NX08_RS04230	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
NX08_RS04240	COG3321	synthase
NX08_RS04240	COG0604	alcohol dehydrogenase
NX08_RS04240	COG1028	Short-chain dehydrogenase reductase Sdr
NX08_RS04300	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
NX08_RS04310	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
NX08_RS04340	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
NX08_RS04350	COG4106	trans-aconitate 2-methyltransferase activity
NX08_RS04355	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
NX08_RS04370	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
NX08_RS04375	COG0667	Aldo Keto reductase
NX08_RS04390	COG4771	TonB-dependent receptor
NX08_RS04410	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NX08_RS04415	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
NX08_RS04425	COG2175	clavaminate synthase activity
NX08_RS04435	COG4181	ATPase activity
NX08_RS04465	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
NX08_RS04485	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
NX08_RS04500	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
NX08_RS04505	COG2967	ApaG domain
NX08_RS04510	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
NX08_RS04520	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
NX08_RS04530	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
NX08_RS04535	COG0123	including yeast histone deacetylase and acetoin utilization protein
NX08_RS04540	COG2096	Adenosyltransferase
NX08_RS04555	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NX08_RS04560	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NX08_RS04585	COG3384	dioxygenase
NX08_RS04590	COG0583	DNA-binding transcription factor activity
NX08_RS04600	COG0318	PFAM AMP-dependent synthetase and ligase
NX08_RS04610	COG1024	Enoyl-CoA hydratase
NX08_RS04630	COG3386	PFAM SMP-30 Gluconolaconase
NX08_RS04655	COG0697	spore germination
NX08_RS04665	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NX08_RS04685	COG5002	protein histidine kinase activity
NX08_RS04685	COG2205	protein histidine kinase activity
NX08_RS04685	COG0784	Response regulator, receiver
NX08_RS04690	COG2197	response regulator
NX08_RS04700	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NX08_RS04710	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
NX08_RS04715	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
NX08_RS04720	COG0583	DNA-binding transcription factor activity
NX08_RS04725	COG3634	alkyl hydroperoxide reductase activity
NX08_RS04735	COG2890	protein-(glutamine-N5) methyltransferase activity
NX08_RS04780	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NX08_RS04780	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NX08_RS04800	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
NX08_RS04825	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
NX08_RS04845	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NX08_RS04850	COG1404	Belongs to the peptidase S8 family
NX08_RS04855	COG1404	Belongs to the peptidase S8 family
NX08_RS04860	COG1404	Belongs to the peptidase S8 family
NX08_RS04865	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
NX08_RS04890	COG1295	ribonuclease BN
NX08_RS04895	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NX08_RS04915	COG0521	Mo-molybdopterin cofactor biosynthetic process
NX08_RS04925	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
NX08_RS04930	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
NX08_RS04940	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
NX08_RS04945	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
NX08_RS04955	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
NX08_RS04960	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
NX08_RS04965	COG0193	aminoacyl-tRNA hydrolase activity
NX08_RS04970	COG0012	GTP binding
NX08_RS04990	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
NX08_RS05000	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
NX08_RS05005	COG0250	Participates in transcription elongation, termination and antitermination
NX08_RS05010	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
NX08_RS05015	COG0081	regulation of translation
NX08_RS05020	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
NX08_RS05030	COG0085	RNA polymerase activity
NX08_RS05035	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
NX08_RS05040	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
NX08_RS05045	COG0049	tRNA binding
NX08_RS05050	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
NX08_RS05055	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
NX08_RS05070	COG0051	transcription antitermination factor activity, RNA binding
NX08_RS05080	COG0088	Forms part of the polypeptide exit tunnel
NX08_RS05090	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
NX08_RS05100	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
NX08_RS05110	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
NX08_RS05115	COG0255	Belongs to the universal ribosomal protein uL29 family
NX08_RS05120	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
NX08_RS05130	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
NX08_RS05165	COG1841	ribosomal large subunit assembly
NX08_RS05170	COG0200	Binds to the 23S rRNA
NX08_RS05175	COG0201	protein transport
NX08_RS05200	COG0203	ribosomal protein L17
NX08_RS05205	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
NX08_RS05220	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
NX08_RS05235	COG0154	amidase activity
NX08_RS05245	COG1217	gtp-binding protein TYPA
NX08_RS05250	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
NX08_RS05260	COG0625	glutathione transferase activity
NX08_RS05280	COG1902	pentaerythritol trinitrate reductase activity
NX08_RS05280	COG0446	pyridine nucleotide-disulphide oxidoreductase
NX08_RS05285	COG0604	alcohol dehydrogenase
NX08_RS05290	COG2885	chlorophyll binding
NX08_RS05310	COG0156	8-amino-7-oxononanoate synthase activity
NX08_RS05315	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
NX08_RS05320	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
NX08_RS05325	COG4208	sulfate ABC transporter
NX08_RS05330	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
NX08_RS05360	COG0406	alpha-ribazole phosphatase activity
NX08_RS05370	COG0285	dihydrofolate synthase activity
NX08_RS05390	COG2833	Protein of unknown function (DUF455)
NX08_RS05395	COG3291	Pkd domain containing protein
NX08_RS05405	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NX08_RS05410	COG0671	phosphoesterase, PA-phosphatase related
NX08_RS05415	COG0438	transferase activity, transferring glycosyl groups
NX08_RS05425	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
NX08_RS05440	COG4783	chaperone-mediated protein folding
NX08_RS05460	COG0473	3-isopropylmalate dehydrogenase activity
NX08_RS05505	COG0544	peptidyl-prolyl cis-trans isomerase activity
NX08_RS05515	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
NX08_RS05545	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NX08_RS05555	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NX08_RS05570	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
NX08_RS05580	COG0631	protein serine/threonine phosphatase activity
NX08_RS05595	COG0859	PFAM glycosyl transferase family 9
NX08_RS05600	COG3642	lipopolysaccharide core region biosynthetic process
NX08_RS05605	COG1234	tRNA 3'-trailer cleavage
NX08_RS05610	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
NX08_RS05620	COG0315	cyclic pyranopterin monophosphate synthase activity
NX08_RS05625	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
NX08_RS05630	COG0314	molybdopterin synthase activity
NX08_RS05650	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
NX08_RS05660	COG0537	adenosine 5'-monophosphoramidase activity
NX08_RS05680	COG0714	Associated with various cellular activities
NX08_RS05705	COG1399	metal-binding, possibly nucleic acid-binding protein
NX08_RS05715	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NX08_RS05730	COG1028	Short-chain dehydrogenase reductase Sdr
NX08_RS05735	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NX08_RS05745	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
NX08_RS05750	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
NX08_RS05770	COG4115	mRNA cleavage
NX08_RS05785	COG3829	transcription factor binding
NX08_RS05805	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
NX08_RS05840	COG2373	Large extracellular alpha-helical protein
NX08_RS05860	COG4953	penicillin-binding protein 1C
NX08_RS05870	COG0678	peroxiredoxin activity
NX08_RS05890	COG0330	HflC and HflK could
NX08_RS05895	COG0330	HflC and HflK could
NX08_RS05900	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
NX08_RS05905	COG0308	aminopeptidase N
NX08_RS05925	COG1309	transcriptional regulator
NX08_RS05950	COG0732	type I restriction modification DNA specificity domain
NX08_RS05975	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
NX08_RS05985	COG3387	PFAM Glycoside hydrolase 15-related
NX08_RS05990	COG1028	Short-chain dehydrogenase reductase Sdr
NX08_RS06010	COG3039	Transposase
NX08_RS06020	COG3537	Alpha-1,2-mannosidase
NX08_RS06025	COG4221	oxidoreductase activity
NX08_RS06095	COG1529	Aldehyde oxidase and xanthine dehydrogenase
NX08_RS06100	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
NX08_RS06105	COG2080	2 iron, 2 sulfur cluster binding
NX08_RS06155	COG0587	DNA-directed DNA polymerase activity
NX08_RS06220	COG2207	Transcriptional regulator
NX08_RS06220	COG1917	Cupin 2, conserved barrel domain protein
NX08_RS06295	COG0753	catalase activity
NX08_RS06300	COG0656	L-ascorbic acid biosynthetic process
NX08_RS06310	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NX08_RS06310	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NX08_RS06335	COG2814	Major facilitator Superfamily
NX08_RS06355	COG0705	Rhomboid family
NX08_RS06365	COG2194	sulfuric ester hydrolase activity
NX08_RS06380	COG0745	RESPONSE REGULATOR receiver
NX08_RS06385	COG0642	Histidine kinase
NX08_RS06395	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
NX08_RS06400	COG2894	cell division
NX08_RS06405	COG0850	regulation of cytokinetic process
NX08_RS06415	COG4585	Histidine kinase
NX08_RS06420	COG2197	response regulator
NX08_RS06435	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
NX08_RS06465	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
NX08_RS06480	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
NX08_RS06510	COG1946	Acyl-CoA thioesterase
NX08_RS06525	COG0824	Thioesterase
NX08_RS06530	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
NX08_RS06535	COG0261	This protein binds to 23S rRNA in the presence of protein L20
NX08_RS06540	COG0211	Belongs to the bacterial ribosomal protein bL27 family
NX08_RS06545	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
NX08_RS06550	COG0268	Binds directly to 16S ribosomal RNA
NX08_RS06555	COG0728	peptidoglycan biosynthetic process
NX08_RS06560	COG0196	riboflavin kinase activity
NX08_RS06565	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
NX08_RS06570	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
NX08_RS06575	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
NX08_RS06590	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
NX08_RS06595	COG1845	cytochrome c oxidase, subunit III
NX08_RS06600	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
NX08_RS06620	COG3152	Membrane
NX08_RS06635	COG2207	Transcriptional regulator
NX08_RS06640	COG0326	Molecular chaperone. Has ATPase activity
NX08_RS06650	COG1366	Belongs to the anti-sigma-factor antagonist family
NX08_RS06655	COG1366	Belongs to the anti-sigma-factor antagonist family
NX08_RS06660	COG2172	sigma factor antagonist activity
NX08_RS06695	COG5507	3-demethylubiquinone-9 3-methyltransferase
NX08_RS06700	COG2205	protein histidine kinase activity
NX08_RS06710	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
NX08_RS06715	COG2205	protein histidine kinase activity
NX08_RS06715	COG3437	response regulator, receiver
NX08_RS06715	COG3850	Histidine kinase
NX08_RS06715	COG4999	Histidine kinase
NX08_RS06720	COG4191	Histidine kinase
NX08_RS06720	COG0784	Response regulator, receiver
NX08_RS06740	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
NX08_RS06745	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
NX08_RS06755	COG2070	2-Nitropropane dioxygenase
NX08_RS06760	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NX08_RS06765	COG0228	four-way junction DNA binding
NX08_RS06770	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
NX08_RS06775	COG0336	Belongs to the RNA methyltransferase TrmD family
NX08_RS06785	COG0534	Mate efflux family protein
NX08_RS06795	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
NX08_RS06805	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
NX08_RS06815	COG1028	Short-chain dehydrogenase reductase Sdr
NX08_RS06820	COG1028	Short-chain dehydrogenase reductase Sdr
NX08_RS06825	COG1028	Short-chain dehydrogenase reductase Sdr
NX08_RS06840	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
NX08_RS06855	COG3250	beta-galactosidase activity
NX08_RS06860	COG3867	Arabinogalactan endo-beta-1,4-galactanase
NX08_RS06880	COG1960	acyl-CoA dehydrogenase activity
NX08_RS06910	COG1024	Enoyl-CoA hydratase
NX08_RS06910	COG1250	3-hydroxyacyl-CoA dehydrogenase
NX08_RS06925	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NX08_RS06945	COG0571	ribonuclease III activity
NX08_RS06950	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
NX08_RS06955	COG1381	Involved in DNA repair and RecF pathway recombination
NX08_RS06970	COG2954	triphosphatase activity
NX08_RS06975	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
NX08_RS06980	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
NX08_RS06985	COG3046	protein related to deoxyribodipyrimidine photolyase
NX08_RS06990	COG1472	Belongs to the glycosyl hydrolase 3 family
NX08_RS06995	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
NX08_RS07000	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
NX08_RS07005	COG1278	Cold shock
NX08_RS07010	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NX08_RS07025	COG1201	RNA secondary structure unwinding
NX08_RS07030	COG1793	dna ligase
NX08_RS07040	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
NX08_RS07040	COG1793	dna ligase
NX08_RS07055	COG5001	Diguanylate cyclase
NX08_RS07075	COG0183	Belongs to the thiolase family
NX08_RS07095	COG1451	nucleotide metabolic process
NX08_RS07105	COG5487	UPF0391 membrane protein
NX08_RS07115	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
NX08_RS07150	COG1047	Peptidyl-prolyl cis-trans
NX08_RS07165	COG2824	Alkylphosphonate utilization operon protein PhnA
NX08_RS07180	COG1902	pentaerythritol trinitrate reductase activity
NX08_RS07185	COG2814	Major facilitator Superfamily
NX08_RS07220	COG0392	lysyltransferase activity
NX08_RS07220	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
NX08_RS07230	COG0251	oxidation-reduction process
NX08_RS07235	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
NX08_RS07250	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
NX08_RS07275	COG1595	DNA-templated transcription, initiation
NX08_RS07290	COG2878	Part of a membrane complex involved in electron transport
NX08_RS07300	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NX08_RS07300	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NX08_RS07310	COG0346	lactoylglutathione lyase activity
NX08_RS07315	COG0833	amino acid
NX08_RS07320	COG2040	homocysteine
NX08_RS07330	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
NX08_RS07370	COG1981	membrane
NX08_RS07385	COG0825	malonyl-CoA metabolic process
NX08_RS07400	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
NX08_RS07405	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NX08_RS07410	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NX08_RS07415	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
NX08_RS07420	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NX08_RS07435	COG0750	zinc metalloprotease
NX08_RS07440	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
NX08_RS07445	COG0575	Belongs to the CDS family
NX08_RS07450	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
NX08_RS07455	COG0233	cytoplasmic translational termination
NX08_RS07460	COG0528	UMP kinase activity
NX08_RS07470	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
NX08_RS07475	COG0052	Belongs to the universal ribosomal protein uS2 family
NX08_RS07515	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
NX08_RS07530	COG1393	Belongs to the ArsC family
NX08_RS07540	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NX08_RS07545	COG0367	asparagine synthase
NX08_RS07555	COG4774	siderophore transport
NX08_RS07575	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
NX08_RS07605	COG1566	PFAM secretion protein HlyD family protein
NX08_RS07610	COG2814	Major facilitator Superfamily
NX08_RS07685	COG0339	signal peptide processing
NX08_RS07695	COG0386	Belongs to the glutathione peroxidase family
NX08_RS07750	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
NX08_RS07755	COG0084	hydrolase, TatD family'
NX08_RS07775	COG1960	acyl-CoA dehydrogenase activity
NX08_RS07795	COG0367	asparagine synthase
NX08_RS07805	COG0305	Participates in initiation and elongation during chromosome replication
NX08_RS07810	COG0415	Belongs to the DNA photolyase family
NX08_RS07820	COG0583	DNA-binding transcription factor activity
NX08_RS07865	COG3706	GGDEF domain
NX08_RS07930	COG0582	viral genome integration into host DNA
NX08_RS07945	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
NX08_RS07955	COG2914	Belongs to the UPF0125 (RnfH) family
NX08_RS07965	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
NX08_RS07975	COG0497	DNA recombination
NX08_RS07980	COG1420	regulation of RNA biosynthetic process
NX08_RS07985	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
NX08_RS07990	COG0443	Heat shock 70 kDa protein
NX08_RS07995	COG0484	heat shock protein binding
NX08_RS08000	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
NX08_RS08030	COG0583	DNA-binding transcription factor activity
NX08_RS08040	COG1132	(ABC) transporter
NX08_RS08075	COG2850	peptidyl-arginine hydroxylation
NX08_RS08115	COG1253	flavin adenine dinucleotide binding
NX08_RS08145	COG1131	(ABC) transporter
NX08_RS08150	COG1725	Transcriptional regulator
NX08_RS08160	COG0386	Belongs to the glutathione peroxidase family
NX08_RS08175	COG2900	Belongs to the SlyX family
NX08_RS08200	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NX08_RS08215	COG0646	methionine synthase
NX08_RS08215	COG1410	methionine synthase
NX08_RS08220	COG2226	methyltransferase
NX08_RS08225	COG1960	acyl-CoA dehydrogenase activity
NX08_RS08230	COG1960	acyl-CoA dehydrogenase activity
NX08_RS08250	COG0557	exoribonuclease II activity
NX08_RS08260	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NX08_RS08280	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
NX08_RS08290	COG0704	Plays a role in the regulation of phosphate uptake
NX08_RS08295	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
NX08_RS08300	COG0581	inorganic phosphate transmembrane transporter activity
NX08_RS08305	COG0573	inorganic phosphate transmembrane transporter activity
NX08_RS08310	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
NX08_RS08340	COG0659	secondary active sulfate transmembrane transporter activity
NX08_RS08350	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
NX08_RS08360	COG1024	Enoyl-CoA hydratase
NX08_RS08370	COG0494	nUDIX hydrolase
NX08_RS08405	COG0488	(ABC) transporter
NX08_RS08415	COG0116	Belongs to the methyltransferase superfamily
NX08_RS08415	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
NX08_RS08420	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
NX08_RS08435	COG0667	Aldo Keto reductase
NX08_RS08445	COG2925	Exonuclease
NX08_RS08450	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NX08_RS08455	COG3844	kynureninase activity
NX08_RS08470	COG0288	reversible hydration of carbon dioxide
NX08_RS08475	COG2808	Putative FMN-binding domain
NX08_RS08495	COG0017	Asparaginyl-tRNA synthetase
NX08_RS08500	COG0316	Belongs to the HesB IscA family
NX08_RS08505	COG0360	Binds together with S18 to 16S ribosomal RNA
NX08_RS08525	COG3115	cell septum assembly
NX08_RS08535	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NX08_RS08540	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
NX08_RS08545	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
NX08_RS08560	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
NX08_RS08605	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
NX08_RS08615	COG2986	histidine ammonia-lyase
NX08_RS08620	COG1228	amidohydrolase
NX08_RS08655	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
NX08_RS08660	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
NX08_RS08665	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
NX08_RS08670	COG0077	Prephenate dehydratase
NX08_RS08670	COG1605	Chorismate mutase
NX08_RS08675	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
NX08_RS08690	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
NX08_RS08695	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
NX08_RS08700	COG0583	DNA-binding transcription factor activity
NX08_RS08735	COG0840	transmembrane signaling receptor activity
NX08_RS08760	COG5002	protein histidine kinase activity
NX08_RS08760	COG2205	protein histidine kinase activity
NX08_RS08760	COG0784	Response regulator, receiver
NX08_RS08765	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
NX08_RS08770	COG4191	Histidine kinase
NX08_RS08770	COG0784	Response regulator, receiver
NX08_RS08785	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NX08_RS08795	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
NX08_RS08805	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
NX08_RS08875	COG2244	polysaccharide biosynthetic process
NX08_RS08900	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
NX08_RS08915	COG0438	transferase activity, transferring glycosyl groups
NX08_RS08930	COG1136	(ABC) transporter
NX08_RS08935	COG1132	(ABC) transporter
NX08_RS08940	COG0477	Major facilitator Superfamily
NX08_RS08950	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NX08_RS08965	COG1253	flavin adenine dinucleotide binding
NX08_RS08980	COG0306	phosphate transporter
NX08_RS08985	COG1434	Gram-negative-bacterium-type cell wall biogenesis
NX08_RS08995	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
NX08_RS09000	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
NX08_RS09015	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
NX08_RS09070	COG0438	transferase activity, transferring glycosyl groups
NX08_RS09075	COG0438	transferase activity, transferring glycosyl groups
NX08_RS09085	COG0438	transferase activity, transferring glycosyl groups
NX08_RS09110	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NX08_RS09115	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NX08_RS09120	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NX08_RS09140	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
NX08_RS09150	COG1960	acyl-CoA dehydrogenase activity
NX08_RS09160	COG3040	lipid binding
NX08_RS09185	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
NX08_RS09195	COG4191	Histidine kinase
NX08_RS09195	COG0784	Response regulator, receiver
NX08_RS09215	COG0552	protein localization to endoplasmic reticulum
NX08_RS09225	COG3938	Belongs to the proline racemase family
NX08_RS09255	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NX08_RS09265	COG0006	proline dipeptidase activity
NX08_RS09280	COG0531	amino acid
NX08_RS09380	COG0326	Molecular chaperone. Has ATPase activity
NX08_RS09385	COG0742	ribosomal rna small subunit methyltransferase
NX08_RS09390	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
NX08_RS09405	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
NX08_RS09410	COG0405	Gamma-glutamyltransferase
NX08_RS09425	COG3291	Pkd domain containing protein
NX08_RS09430	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
NX08_RS09470	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
NX08_RS09475	COG0343	queuine tRNA-ribosyltransferase activity
NX08_RS09480	COG1862	Preprotein translocase
NX08_RS09490	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NX08_RS09525	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NX08_RS09525	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NX08_RS09530	COG1105	Belongs to the carbohydrate kinase PfkB family
NX08_RS09535	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NX08_RS09535	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
NX08_RS09540	COG1609	Transcriptional regulator
NX08_RS09595	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NX08_RS09600	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NX08_RS09610	COG2902	Dehydrogenase
NX08_RS09615	COG0477	Major facilitator Superfamily
NX08_RS09630	COG2205	protein histidine kinase activity
NX08_RS09630	COG0784	Response regulator, receiver
NX08_RS09630	COG5002	protein histidine kinase activity
NX08_RS09635	COG2733	membrane
NX08_RS09645	COG1121	(ABC) transporter
NX08_RS09650	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
NX08_RS09660	COG2223	nitrite transmembrane transporter activity
NX08_RS09665	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
NX08_RS09670	COG0243	molybdopterin cofactor binding
NX08_RS09685	COG0477	Major facilitator Superfamily
NX08_RS09695	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NX08_RS09700	COG0174	glutamine synthetase
NX08_RS09720	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
NX08_RS09740	COG3842	ATPase activity
NX08_RS09745	COG1176	ABC-type spermidine putrescine transport system, permease component I
NX08_RS09750	COG1177	transmembrane transport
NX08_RS09755	COG1012	belongs to the aldehyde dehydrogenase family
NX08_RS09770	COG4535	Mg2 and Co2 transporter CorC
NX08_RS09795	COG1702	phosphate starvation-inducible protein PhoH
NX08_RS09815	COG0741	lytic transglycosylase activity
NX08_RS09820	COG0723	plastoquinol--plastocyanin reductase activity
NX08_RS09825	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
NX08_RS09830	COG2857	Cytochrome c1
NX08_RS09835	COG0625	glutathione transferase activity
NX08_RS09840	COG2969	positive regulation of protein catabolic process
NX08_RS09860	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
NX08_RS09865	COG1201	RNA secondary structure unwinding
NX08_RS09870	COG2094	Belongs to the DNA glycosylase MPG family
NX08_RS09875	COG0840	transmembrane signaling receptor activity
NX08_RS09880	COG0835	chemotaxis
NX08_RS09925	COG1262	PFAM Formylglycine-generating sulfatase enzyme
NX08_RS09945	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
NX08_RS09950	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
NX08_RS09950	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
NX08_RS09955	COG0802	atpase or kinase
NX08_RS09960	COG0860	N-Acetylmuramoyl-L-alanine amidase
NX08_RS09965	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
NX08_RS09990	COG1028	Short-chain dehydrogenase reductase Sdr
NX08_RS10000	COG0501	Belongs to the peptidase M48B family
NX08_RS10010	COG2081	HI0933 family
NX08_RS10020	COG1671	Belongs to the UPF0178 family
NX08_RS10030	COG0625	glutathione transferase activity
NX08_RS10040	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
NX08_RS10045	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
NX08_RS10050	COG0513	Belongs to the DEAD box helicase family
NX08_RS10055	COG0488	(ABC) transporter
NX08_RS10075	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
NX08_RS10080	COG0483	inositol monophosphate 1-phosphatase activity
NX08_RS10095	COG3300	MHYT domain
NX08_RS10095	COG5001	Diguanylate cyclase
NX08_RS10105	COG1509	lysine 2,3-aminomutase activity
NX08_RS10110	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
NX08_RS10125	COG0402	S-adenosylhomocysteine deaminase activity
NX08_RS10130	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
NX08_RS10165	COG4302	ethanolamine ammonia-lyase activity
NX08_RS10185	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
NX08_RS10205	COG2166	iron-sulfur cluster assembly
NX08_RS10220	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
NX08_RS10225	COG0137	argininosuccinate synthase activity
NX08_RS10235	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NX08_RS10240	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
NX08_RS10250	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
NX08_RS10255	COG0165	Argininosuccinate lyase
NX08_RS10310	COG4988	ABC transporter
NX08_RS10315	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
NX08_RS10325	COG1278	Cold shock
NX08_RS10330	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
NX08_RS10355	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
NX08_RS10375	COG4133	protoheme IX ABC transporter activity
NX08_RS10380	COG0436	Aminotransferase
NX08_RS10405	COG1187	pseudouridine synthase activity
NX08_RS10410	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
NX08_RS10415	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
NX08_RS10420	COG2350	Protein conserved in bacteria
NX08_RS10450	COG1175	transmembrane transport
NX08_RS10455	COG0395	ABC-type sugar transport system, permease component
NX08_RS10480	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NX08_RS10490	COG2957	Belongs to the agmatine deiminase family
NX08_RS10510	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
NX08_RS10515	COG0539	negative regulation of cytoplasmic translation
NX08_RS10520	COG0776	regulation of translation
NX08_RS10530	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
NX08_RS10545	COG1210	Utp--glucose-1-phosphate uridylyltransferase
NX08_RS10565	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
NX08_RS10580	COG0582	viral genome integration into host DNA
NX08_RS10645	COG3846	protein secretion by the type IV secretion system
NX08_RS10690	COG3002	Belongs to the UPF0753 family
NX08_RS10695	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
NX08_RS10700	COG0583	DNA-binding transcription factor activity
NX08_RS10705	COG0583	DNA-binding transcription factor activity
NX08_RS10715	COG1028	Short-chain dehydrogenase reductase Sdr
NX08_RS10725	COG0583	DNA-binding transcription factor activity
NX08_RS10740	COG2197	response regulator
NX08_RS10765	COG1335	isochorismatase
NX08_RS10780	COG2814	Major facilitator Superfamily
NX08_RS10795	COG1914	H( )-stimulated, divalent metal cation uptake system
NX08_RS10810	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
NX08_RS10815	COG0668	transmembrane transport
NX08_RS10825	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
NX08_RS10840	COG1028	Short-chain dehydrogenase reductase Sdr
NX08_RS10845	COG1183	phosphatidylcholine synthase activity
NX08_RS10855	COG3243	poly(R)-hydroxyalkanoic acid synthase
NX08_RS10870	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NX08_RS10870	COG0723	plastoquinol--plastocyanin reductase activity
NX08_RS10880	COG2183	response to ionizing radiation
NX08_RS10890	COG2205	protein histidine kinase activity
NX08_RS10890	COG0784	Response regulator, receiver
NX08_RS10965	COG0800	Aldolase
NX08_RS10970	COG0129	dihydroxy-acid dehydratase activity
NX08_RS10975	COG0363	glucosamine-6-phosphate deaminase activity
NX08_RS10980	COG0837	glucose binding
NX08_RS10985	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
NX08_RS11015	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
NX08_RS11030	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
NX08_RS11035	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
NX08_RS11045	COG4591	ABC-type transport system involved in lipoprotein release permease component
NX08_RS11065	COG0811	peptide transport
NX08_RS11075	COG1132	(ABC) transporter
NX08_RS11080	COG1663	tetraacyldisaccharide 4'-kinase activity
NX08_RS11085	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
NX08_RS11090	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NX08_RS11100	COG0322	excinuclease ABC activity
NX08_RS11105	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
NX08_RS11130	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
NX08_RS11150	COG1054	Belongs to the UPF0176 family
NX08_RS11165	COG1530	ribonuclease E activity
NX08_RS11175	COG3064	Membrane
NX08_RS11180	COG0428	transporter
NX08_RS11195	COG2154	pterin-4-alpha-carbinolamine dehydratase
NX08_RS11240	COG1858	cytochrome C peroxidase
NX08_RS11270	COG0515	serine threonine protein kinase
NX08_RS11275	COG0631	protein serine/threonine phosphatase activity
NX08_RS11370	COG2801	Transposase and inactivated derivatives
NX08_RS11430	COG4566	intracellular signal transduction
NX08_RS11440	COG5001	Diguanylate cyclase
NX08_RS11455	COG3685	Protein conserved in bacteria
NX08_RS11480	COG1648	precorrin-2 dehydrogenase activity
NX08_RS11480	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
NX08_RS11490	COG0746	molybdenum cofactor guanylyltransferase activity
NX08_RS11495	COG0303	'Molybdopterin
NX08_RS11500	COG0708	Exodeoxyribonuclease III
NX08_RS11525	COG2124	cytochrome p450
NX08_RS11540	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
NX08_RS11545	COG0303	'Molybdopterin
NX08_RS11555	COG1160	GTP binding
NX08_RS11560	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
NX08_RS11580	COG0820	rRNA (adenine-C2-)-methyltransferase activity
NX08_RS11595	COG1024	Enoyl-CoA hydratase
NX08_RS11595	COG1250	3-hydroxyacyl-CoA dehydrogenase
NX08_RS11600	COG0183	Belongs to the thiolase family
NX08_RS11605	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
NX08_RS11610	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
NX08_RS11630	COG1674	ftsk spoiiie
NX08_RS11635	COG0492	ferredoxin-NADP+ reductase activity
NX08_RS11645	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
NX08_RS11655	COG0542	response to heat
NX08_RS11670	COG0482	sulfurtransferase activity
NX08_RS11700	COG4585	Histidine kinase
NX08_RS11710	COG5002	protein histidine kinase activity
NX08_RS11730	COG0835	chemotaxis
NX08_RS11730	COG0784	Response regulator, receiver
NX08_RS11740	COG1558	bacterial-type flagellum-dependent cell motility
NX08_RS11745	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
NX08_RS11755	COG4787	bacterial-type flagellum-dependent cell motility
NX08_RS11775	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
NX08_RS11780	COG1706	bacterial-type flagellum-dependent cell motility
NX08_RS11800	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
NX08_RS11805	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
NX08_RS11810	COG1516	flagellar protein fliS
NX08_RS11835	COG2201	protein-glutamate methylesterase activity
NX08_RS11855	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NX08_RS11860	COG1028	Short-chain dehydrogenase reductase Sdr
NX08_RS11865	COG1028	Short-chain dehydrogenase reductase Sdr
NX08_RS11895	COG1677	Flagellar hook-basal body complex protein FliE
NX08_RS11945	COG3190	flagellar
NX08_RS11965	COG1684	flagellar biosynthetic protein fliR
NX08_RS12025	COG0643	Histidine kinase
NX08_RS12025	COG2198	Histidine kinase
NX08_RS12025	COG0784	Response regulator, receiver
NX08_RS12085	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
NX08_RS12090	COG1360	Flagellar Motor Protein
NX08_RS12095	COG1192	Involved in chromosome partitioning
NX08_RS12100	COG0835	chemotaxis
NX08_RS12110	COG0745	RESPONSE REGULATOR receiver
NX08_RS12120	COG0840	transmembrane signaling receptor activity
NX08_RS12140	COG0840	transmembrane signaling receptor activity
NX08_RS12150	COG0840	transmembrane signaling receptor activity
NX08_RS12155	COG0840	transmembrane signaling receptor activity
NX08_RS12160	COG0840	transmembrane signaling receptor activity
NX08_RS12165	COG0840	transmembrane signaling receptor activity
NX08_RS12175	COG0840	transmembrane signaling receptor activity
NX08_RS12180	COG0840	transmembrane signaling receptor activity
NX08_RS12195	COG0835	chemotaxis
NX08_RS12220	COG2201	protein-glutamate methylesterase activity
NX08_RS12230	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
NX08_RS12260	COG0318	PFAM AMP-dependent synthetase and ligase
NX08_RS12270	COG3039	Transposase
NX08_RS12285	COG1024	Enoyl-CoA hydratase
NX08_RS12295	COG2198	Histidine kinase
NX08_RS12295	COG0784	Response regulator, receiver
NX08_RS12295	COG2205	protein histidine kinase activity
NX08_RS12305	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
NX08_RS12335	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
NX08_RS12345	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
NX08_RS12350	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
NX08_RS12360	COG0505	Belongs to the CarA family
NX08_RS12365	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
NX08_RS12370	COG2258	MOSC domain
NX08_RS12375	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NX08_RS12420	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
NX08_RS12440	COG0277	FAD linked oxidase domain protein
NX08_RS12445	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NX08_RS12460	COG0531	amino acid
NX08_RS12465	COG0235	Class ii aldolase
NX08_RS12470	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
NX08_RS12500	COG0140	phosphoribosyl-ATP diphosphatase activity
NX08_RS12500	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
NX08_RS12505	COG0107	imidazoleglycerol-phosphate synthase activity
NX08_RS12510	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
NX08_RS12515	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
NX08_RS12520	COG0131	Imidazoleglycerol-phosphate dehydratase
NX08_RS12520	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
NX08_RS12525	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NX08_RS12530	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
NX08_RS12535	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
NX08_RS12545	COG0124	histidyl-tRNA synthetase
NX08_RS12550	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NX08_RS12560	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
NX08_RS12605	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NX08_RS12665	COG3620	sequence-specific DNA binding
NX08_RS12880	COG3220	belongs to the UPF0276 family
NX08_RS12895	COG0688	phosphatidylethanolamine metabolic process
NX08_RS12900	COG2003	Belongs to the UPF0758 family
NX08_RS12960	COG1012	belongs to the aldehyde dehydrogenase family
NX08_RS12980	COG0812	UDP-N-acetylmuramate dehydrogenase activity
NX08_RS12985	COG0697	spore germination
NX08_RS12995	COG1794	racemase activity, acting on amino acids and derivatives
NX08_RS13010	COG0671	phosphoesterase, PA-phosphatase related
NX08_RS13015	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
NX08_RS13025	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
NX08_RS13030	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
NX08_RS13055	COG1472	Belongs to the glycosyl hydrolase 3 family
NX08_RS13080	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
NX08_RS13085	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
NX08_RS13090	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
NX08_RS13100	COG0617	tRNA 3'-terminal CCA addition
NX08_RS13115	COG1469	GTP cyclohydrolase I activity
NX08_RS13145	COG0477	Major facilitator Superfamily
NX08_RS13155	COG1070	Carbohydrate kinase
NX08_RS13165	COG1501	Belongs to the glycosyl hydrolase 31 family
NX08_RS13225	COG0800	Aldolase
NX08_RS13230	COG4948	Mandelate Racemase Muconate Lactonizing
NX08_RS13240	COG3734	2-keto-3-deoxy-galactonokinase
NX08_RS13245	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
NX08_RS13255	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NX08_RS13270	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
NX08_RS13275	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
NX08_RS13290	COG0351	phosphomethylpyrimidine kinase
NX08_RS13290	COG0352	thiamine-phosphate diphosphorylase activity
NX08_RS13315	COG0583	DNA-binding transcription factor activity
NX08_RS13320	COG1741	Belongs to the pirin family
NX08_RS13340	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
NX08_RS13345	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
NX08_RS13350	COG2137	regulation of response to DNA damage stimulus
NX08_RS13355	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
NX08_RS13370	COG1546	Belongs to the CinA family
NX08_RS13375	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
NX08_RS13385	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
NX08_RS13390	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
NX08_RS13400	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
NX08_RS13405	COG1534	Rna-binding protein
NX08_RS13420	COG1238	metal cluster binding
NX08_RS13425	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
NX08_RS13430	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
NX08_RS13435	COG2840	Smr protein MutS2
NX08_RS13445	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
NX08_RS13455	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
NX08_RS13460	COG0148	phosphopyruvate hydratase activity
NX08_RS13480	COG0504	CTP synthase activity
NX08_RS13530	COG3702	type iv secretory pathway
NX08_RS13550	COG2948	multi-organism process
NX08_RS13570	COG3505	Type IV secretory pathway VirD4
NX08_RS13585	COG0556	nucleotide-excision repair
NX08_RS13590	COG4969	Belongs to the N-Me-Phe pilin family
NX08_RS13630	COG1611	Belongs to the LOG family
NX08_RS13640	COG2095	MarC family integral membrane protein
NX08_RS13650	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
NX08_RS13655	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
NX08_RS13685	COG1185	polyribonucleotide nucleotidyltransferase activity
NX08_RS13690	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
NX08_RS13700	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
NX08_RS13705	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
NX08_RS13710	COG0195	Participates in both transcription termination and antitermination
NX08_RS13715	COG0779	Required for maturation of 30S ribosomal subunits
NX08_RS13725	COG1007	ATP synthesis coupled electron transport
NX08_RS13750	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NX08_RS13755	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
NX08_RS13760	COG1034	ATP synthesis coupled electron transport
NX08_RS13765	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
NX08_RS13770	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
NX08_RS13775	COG0649	NAD binding
NX08_RS13780	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NX08_RS13790	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NX08_RS13805	COG0149	triose-phosphate isomerase activity
NX08_RS13865	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NX08_RS13870	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
NX08_RS13890	COG0133	tryptophan synthase activity
NX08_RS13900	COG0135	phosphoribosylanthranilate isomerase activity
NX08_RS13905	COG0101	tRNA pseudouridine synthase activity
NX08_RS13925	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
NX08_RS13930	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NX08_RS13935	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
NX08_RS13940	COG2890	protein-(glutamine-N5) methyltransferase activity
NX08_RS13950	COG0688	phosphatidylethanolamine metabolic process
NX08_RS13955	COG0688	phosphatidylethanolamine metabolic process
NX08_RS13965	COG0433	COG0433 Predicted ATPase
NX08_RS13995	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
NX08_RS14015	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NX08_RS14050	COG0717	Belongs to the dCTP deaminase family
NX08_RS14060	COG0489	protein tyrosine kinase activity
NX08_RS14080	COG3590	peptidase
NX08_RS14085	COG3590	peptidase
NX08_RS14105	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NX08_RS14110	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NX08_RS14115	COG2311	Membrane
NX08_RS14120	COG1047	Peptidyl-prolyl cis-trans
NX08_RS14125	COG0791	NLP P60 protein
NX08_RS14130	COG0791	NLP P60 protein
NX08_RS14145	COG1301	dicarboxylic acid transport
NX08_RS14150	COG1785	Belongs to the alkaline phosphatase family
NX08_RS14155	COG0037	tRNA processing
NX08_RS14160	COG1722	exodeoxyribonuclease VII activity
NX08_RS14165	COG0142	geranyltranstransferase activity
NX08_RS14170	COG4104	PAAR repeat-containing protein
NX08_RS14180	COG0312	modulator of DNA gyrase
NX08_RS14190	COG0312	modulator of DNA gyrase
NX08_RS14205	COG3164	Protein of unknown function
NX08_RS14220	COG2968	Membrane
NX08_RS14235	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
NX08_RS14255	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
NX08_RS14285	COG3118	belongs to the thioredoxin family
NX08_RS14300	COG2155	Conserved Protein
NX08_RS14360	COG1132	(ABC) transporter
NX08_RS14385	COG1538	Outer membrane efflux protein
NX08_RS14390	COG0745	RESPONSE REGULATOR receiver
NX08_RS14395	COG5002	protein histidine kinase activity
NX08_RS14395	COG5000	phosphorelay sensor kinase activity
NX08_RS14400	COG0475	glutathione-regulated potassium exporter activity
NX08_RS14410	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
NX08_RS14440	COG1187	pseudouridine synthase activity
NX08_RS14445	COG5002	protein histidine kinase activity
NX08_RS14445	COG5001	Diguanylate cyclase
NX08_RS14555	COG0667	Aldo Keto reductase
NX08_RS14560	COG2814	Major facilitator Superfamily
NX08_RS14565	COG0583	DNA-binding transcription factor activity
NX08_RS14580	COG2207	Transcriptional regulator
NX08_RS14615	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NX08_RS14665	COG0735	belongs to the Fur family
NX08_RS14670	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NX08_RS14695	COG4452	Inner membrane protein CreD
NX08_RS14705	COG2205	protein histidine kinase activity
NX08_RS14715	COG0745	RESPONSE REGULATOR receiver
NX08_RS14720	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
NX08_RS14730	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
NX08_RS14785	COG0643	Histidine kinase
NX08_RS14785	COG2198	Histidine kinase
NX08_RS14790	COG0840	transmembrane signaling receptor activity
NX08_RS14795	COG0835	chemotaxis
NX08_RS14805	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
NX08_RS14815	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NX08_RS14820	COG3590	peptidase
NX08_RS14830	COG0588	phosphoglycerate mutase activity
NX08_RS14835	COG1515	deoxyribonuclease V activity
NX08_RS14840	COG1741	Belongs to the pirin family
NX08_RS14860	COG1741	Belongs to the pirin family
NX08_RS14865	COG1966	Carbon starvation protein
NX08_RS14870	COG2879	small protein
NX08_RS14910	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
NX08_RS14915	COG1529	Aldehyde oxidase and xanthine dehydrogenase
NX08_RS14935	COG2080	2 iron, 2 sulfur cluster binding
NX08_RS14940	COG3321	synthase
NX08_RS14940	COG1028	Short-chain dehydrogenase reductase Sdr
NX08_RS14940	COG0604	alcohol dehydrogenase
NX08_RS14945	COG3706	GGDEF domain
NX08_RS14945	COG4251	negative regulation of phosphorylation
NX08_RS14945	COG2203	Gaf domain
NX08_RS14945	COG5001	Diguanylate cyclase
NX08_RS14950	COG0629	single-stranded DNA binding
NX08_RS14955	COG0142	geranyltranstransferase activity
NX08_RS14980	COG0527	aspartate kinase activity
NX08_RS14985	COG0384	phenazine biosynthesis protein PhzF
NX08_RS14990	COG0384	phenazine biosynthesis protein PhzF
NX08_RS15000	COG1764	response to oxidative stress
NX08_RS15015	COG0540	Belongs to the ATCase OTCase family
NX08_RS15020	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
NX08_RS15025	COG1678	Uncharacterized ACR, COG1678
NX08_RS15030	COG0519	Catalyzes the synthesis of GMP from XMP
NX08_RS15065	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
NX08_RS15080	COG4942	peptidase
NX08_RS15100	COG0693	protein deglycase activity
NX08_RS15110	COG1959	2 iron, 2 sulfur cluster binding
NX08_RS15115	COG0719	Fe-S assembly protein
NX08_RS15120	COG0396	ATPase activity
NX08_RS15125	COG0719	Fe-S assembly protein
NX08_RS15130	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
NX08_RS15145	COG2146	nitrite reductase [NAD(P)H] activity
NX08_RS15150	COG4774	siderophore transport
NX08_RS15155	COG3128	pkhd-type hydroxylase
NX08_RS15180	COG1477	protein flavinylation
NX08_RS15195	COG1555	photosystem II stabilization
NX08_RS15200	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NX08_RS15210	COG3178	'Phosphotransferase
NX08_RS15215	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
NX08_RS15230	COG0628	permease
NX08_RS15240	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
NX08_RS15250	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
NX08_RS15275	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
NX08_RS15280	COG0271	Belongs to the BolA IbaG family
NX08_RS15290	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
NX08_RS15300	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
NX08_RS15305	COG1137	ATPase activity
NX08_RS15320	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NX08_RS15330	COG1660	Displays ATPase and GTPase activities
NX08_RS15340	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
NX08_RS15345	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NX08_RS15355	COG2239	Acts as a magnesium transporter
NX08_RS15370	COG1294	oxidase, subunit
NX08_RS15375	COG1271	oxidase subunit
NX08_RS15385	COG1113	amino acid transport
NX08_RS15410	COG2197	response regulator
NX08_RS15415	COG0531	amino acid
NX08_RS15480	COG2814	Major facilitator Superfamily
NX08_RS15490	COG0754	glutathionylspermidine amidase activity
NX08_RS15515	COG1842	Phage shock protein A
NX08_RS15525	COG0259	pyridoxamine-phosphate oxidase activity
NX08_RS15530	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
NX08_RS15535	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
NX08_RS15550	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
NX08_RS15580	COG5002	protein histidine kinase activity
NX08_RS15580	COG0784	Response regulator, receiver
NX08_RS15590	COG2353	YceI-like domain
NX08_RS15620	COG1760	l-serine dehydratase
NX08_RS15630	COG0460	homoserine dehydrogenase
NX08_RS15630	COG0527	aspartate kinase activity
NX08_RS15635	COG0626	cystathionine gamma-synthase activity
NX08_RS15640	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
NX08_RS15645	COG0739	heme binding
NX08_RS15650	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
NX08_RS15655	COG1272	protein, Hemolysin III
NX08_RS15660	COG2982	Protein involved in outer membrane biogenesis
NX08_RS15670	COG0463	Glycosyl transferase, family 2
NX08_RS15680	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
NX08_RS15695	COG1309	transcriptional regulator
NX08_RS15700	COG2267	carboxylic ester hydrolase activity
NX08_RS15705	COG1960	acyl-CoA dehydrogenase activity
NX08_RS15740	COG0509	glycine decarboxylation via glycine cleavage system
NX08_RS15745	COG0404	The glycine cleavage system catalyzes the degradation of glycine
NX08_RS15760	COG1742	UPF0060 membrane protein
NX08_RS15765	COG3956	TIGRFAM MazG family protein
NX08_RS15775	COG0494	nUDIX hydrolase
NX08_RS15785	COG1385	rRNA (uridine-N3-)-methyltransferase activity
NX08_RS15790	COG0837	glucose binding
NX08_RS15805	COG1388	LysM domain
NX08_RS15805	COG3858	chitin binding
NX08_RS15840	COG1472	Belongs to the glycosyl hydrolase 3 family
NX08_RS15900	COG3537	Alpha-1,2-mannosidase
NX08_RS15950	COG3142	Participates in the control of copper homeostasis
NX08_RS15955	COG1446	asparaginase
NX08_RS15990	COG0784	Response regulator, receiver
NX08_RS15990	COG2198	Histidine kinase
NX08_RS15990	COG0643	Histidine kinase
NX08_RS15995	COG0840	transmembrane signaling receptor activity
NX08_RS16000	COG0835	chemotaxis
NX08_RS16015	COG0189	ligase activity
NX08_RS16025	COG1397	ADP-ribosylglycohydrolase
NX08_RS16035	COG1199	ATP-dependent helicase activity
NX08_RS16045	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NX08_RS16055	COG1215	transferase activity, transferring glycosyl groups
NX08_RS16070	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NX08_RS16080	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
NX08_RS16085	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
NX08_RS16115	COG0837	glucose binding
NX08_RS16130	COG1643	Atp-dependent helicase
NX08_RS16135	COG0783	Belongs to the Dps family
NX08_RS16145	COG0514	ATP-dependent DNA helicase (RecQ)
NX08_RS16180	COG1187	pseudouridine synthase activity
NX08_RS16210	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
NX08_RS16455	COG4695	Portal protein
NX08_RS16500	COG0602	queuosine metabolic process
NX08_RS16510	COG2885	chlorophyll binding
NX08_RS16515	COG0823	Involved in the tonB-independent uptake of proteins
NX08_RS16525	COG0848	biopolymer transport protein
NX08_RS16535	COG0824	Thioesterase
NX08_RS16540	COG2255	four-way junction helicase activity
NX08_RS16545	COG3158	transport of potassium into the cell
NX08_RS16555	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
NX08_RS16575	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
NX08_RS16595	COG0477	Major facilitator Superfamily
NX08_RS16625	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
NX08_RS16640	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
NX08_RS16650	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
NX08_RS16655	COG0174	glutamine synthetase
NX08_RS16710	COG0488	(ABC) transporter
NX08_RS16750	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
NX08_RS16750	COG4651	solute:proton antiporter activity
NX08_RS16760	COG4772	TonB-dependent receptor
NX08_RS16770	COG4264	IucA IucC family
NX08_RS16775	COG2814	Major facilitator Superfamily
NX08_RS16785	COG0019	diaminopimelate decarboxylase activity
NX08_RS16805	COG4206	TonB-dependent receptor
NX08_RS16825	COG0542	response to heat
NX08_RS16830	COG1116	anion transmembrane transporter activity
NX08_RS16835	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NX08_RS16840	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
NX08_RS16850	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NX08_RS16855	COG4771	TonB-dependent receptor
NX08_RS16860	COG2827	Endonuclease containing a URI domain
NX08_RS16910	COG1877	trehalose-phosphatase activity
NX08_RS16915	COG3387	PFAM Glycoside hydrolase 15-related
NX08_RS16930	COG0840	transmembrane signaling receptor activity
NX08_RS16935	COG3011	Protein conserved in bacteria
NX08_RS16950	COG0564	pseudouridine synthase activity
NX08_RS16955	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
NX08_RS16960	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
NX08_RS16960	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NX08_RS16975	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
NX08_RS16980	COG0045	succinate-CoA ligase (ADP-forming) activity
NX08_RS17010	COG1459	type II secretion system
NX08_RS17015	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
NX08_RS17030	COG0745	RESPONSE REGULATOR receiver
NX08_RS17190	COG4248	protein with protein kinase and helix-hairpin-helix DNA-binding domains
NX08_RS17195	COG0631	protein serine/threonine phosphatase activity
NX08_RS17200	COG4245	von Willebrand factor, type A
NX08_RS17220	COG3209	COG3209 Rhs family protein
NX08_RS17265	COG2022	thiamine diphosphate biosynthetic process
NX08_RS17270	COG0220	tRNA (guanine-N7-)-methyltransferase activity
NX08_RS17275	COG3273	potassium ion transport
NX08_RS17275	COG0471	metal ion transport
NX08_RS17295	COG1970	mechanosensitive ion channel activity
NX08_RS17305	COG1609	Transcriptional regulator
NX08_RS17340	COG4948	Mandelate Racemase Muconate Lactonizing
NX08_RS17355	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NX08_RS17370	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NX08_RS17380	COG2895	sulfate adenylyltransferase (ATP) activity
NX08_RS17380	COG0529	Catalyzes the synthesis of activated sulfate
NX08_RS17385	COG0175	sulfate reduction
NX08_RS17390	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
NX08_RS17395	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NX08_RS17400	COG0175	sulfate reduction
NX08_RS17420	COG2198	Histidine kinase
NX08_RS17420	COG2205	protein histidine kinase activity
NX08_RS17420	COG0784	Response regulator, receiver
NX08_RS17435	COG0583	DNA-binding transcription factor activity
NX08_RS17455	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
NX08_RS17460	COG3588	fructose-bisphosphate aldolase
NX08_RS17470	COG0469	pyruvate kinase activity
NX08_RS17505	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
NX08_RS17525	COG3047	cAMP biosynthetic process
NX08_RS17535	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NX08_RS17535	COG3453	Protein conserved in bacteria
NX08_RS17540	COG0725	ABC transporter, periplasmic molybdate-binding protein
NX08_RS17545	COG4149	molybdate abc transporter
NX08_RS17570	COG1376	ErfK ybiS ycfS ynhG family protein
NX08_RS17575	COG0739	heme binding
NX08_RS17580	COG1028	Short-chain dehydrogenase reductase Sdr
NX08_RS17585	COG0583	DNA-binding transcription factor activity
NX08_RS17590	COG4773	Receptor
NX08_RS17605	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
NX08_RS17610	COG1301	dicarboxylic acid transport
NX08_RS17625	COG2304	oxidoreductase activity
NX08_RS17645	COG0714	Associated with various cellular activities
NX08_RS17675	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
NX08_RS17695	COG1957	nucleoside hydrolase
NX08_RS17700	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
NX08_RS17710	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NX08_RS17730	COG1561	YicC-like family, N-terminal region
NX08_RS17735	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
NX08_RS17750	COG0635	Involved in the biosynthesis of porphyrin-containing compound
NX08_RS17765	COG0006	proline dipeptidase activity
NX08_RS17775	COG0006	proline dipeptidase activity
NX08_RS17800	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
NX08_RS17820	COG2912	Transglutaminase-like superfamily
NX08_RS17825	COG1773	rubredoxin
NX08_RS17830	COG0352	thiamine-phosphate diphosphorylase activity
NX08_RS17850	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
NX08_RS17860	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
NX08_RS17865	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NX08_RS17895	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NX08_RS17900	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NX08_RS17910	COG1028	Short-chain dehydrogenase reductase Sdr
NX08_RS17920	COG0671	phosphoesterase, PA-phosphatase related
NX08_RS17925	COG3781	membrane
NX08_RS17935	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
NX08_RS17955	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
NX08_RS17965	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
NX08_RS17985	COG3710	Transcriptional regulator
NX08_RS17990	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
NX08_RS18005	COG0840	transmembrane signaling receptor activity
NX08_RS18015	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
NX08_RS18035	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NX08_RS18040	COG0473	3-isopropylmalate dehydrogenase activity
NX08_RS18045	COG2226	methyltransferase
NX08_RS18050	COG0066	3-isopropylmalate dehydratase activity
NX08_RS18060	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
NX08_RS18085	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
NX08_RS18090	COG1538	Outer membrane efflux protein
NX08_RS18095	COG1519	Transferase
NX08_RS18100	COG1560	Kdo2-lipid A biosynthetic process
NX08_RS18130	COG0280	phosphate acetyltransferase
NX08_RS18130	COG0281	malic enzyme
NX08_RS18135	COG1301	dicarboxylic acid transport
NX08_RS18150	COG4191	Histidine kinase
NX08_RS18165	COG0583	DNA-binding transcription factor activity
NX08_RS18170	COG0667	Aldo Keto reductase
NX08_RS18185	COG2197	response regulator
NX08_RS18195	COG0642	Histidine kinase
NX08_RS18220	COG2851	Citrate transporter
NX08_RS18225	COG1028	Short-chain dehydrogenase reductase Sdr
NX08_RS18230	COG1609	Transcriptional regulator
NX08_RS18235	COG2211	Major facilitator Superfamily
NX08_RS18260	COG1162	GTPase activity
NX08_RS18265	COG0436	Aminotransferase
NX08_RS18285	COG0726	polysaccharide deacetylase
NX08_RS18290	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
NX08_RS18305	COG3964	amidohydrolase
NX08_RS18310	COG0402	S-adenosylhomocysteine deaminase activity
NX08_RS18365	COG3791	Glutathione-dependent formaldehyde-activating
NX08_RS18390	COG2205	protein histidine kinase activity
NX08_RS18420	COG0218	Necessary for normal cell division and for the maintenance of normal septation
NX08_RS18435	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
NX08_RS18465	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
NX08_RS18470	COG0456	acetyltransferase
NX08_RS18480	COG1183	phosphatidylcholine synthase activity
NX08_RS18490	COG0442	prolyl-tRNA aminoacylation
NX08_RS18505	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
NX08_RS18510	COG1127	ABC transporter
NX08_RS18515	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
NX08_RS18515	COG3218	ABC-type transport auxiliary lipoprotein component
NX08_RS18555	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NX08_RS18560	COG0662	Cupin 2, conserved barrel domain protein
NX08_RS18560	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
NX08_RS18585	COG2086	electron transfer activity
NX08_RS18600	COG0546	phosphoglycolate phosphatase activity
NX08_RS18600	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
NX08_RS18605	COG0277	FAD linked oxidase domain protein
NX08_RS18615	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NX08_RS18645	COG0438	transferase activity, transferring glycosyl groups
NX08_RS18680	COG0626	cystathionine gamma-synthase activity
NX08_RS18710	COG0625	glutathione transferase activity
NX08_RS18725	COG0513	Belongs to the DEAD box helicase family
NX08_RS18735	COG0720	synthase
NX08_RS18745	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
NX08_RS18750	COG1956	GAF domain-containing protein
NX08_RS18760	COG0546	phosphoglycolate phosphatase activity
NX08_RS18765	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
NX08_RS18790	COG0339	signal peptide processing
NX08_RS18840	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
NX08_RS18845	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NX08_RS18850	COG1136	(ABC) transporter
NX08_RS18855	COG0577	efflux transmembrane transporter activity
NX08_RS18860	COG0577	efflux transmembrane transporter activity
NX08_RS18870	COG4191	Histidine kinase
NX08_RS18910	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
NX08_RS18915	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
NX08_RS18920	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
NX08_RS18925	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
NX08_RS18940	COG0356	it plays a direct role in the translocation of protons across the membrane
NX08_RS18960	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NX08_RS18970	COG0508	dehydrogenase complex catalyzes the overall conversion of
NX08_RS19015	COG2011	ABC-type metal ion transport system permease component
NX08_RS19020	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
NX08_RS19025	COG0697	spore germination
NX08_RS19030	COG1666	GTP binding
NX08_RS19070	COG1187	pseudouridine synthase activity
NX08_RS19075	COG2813	Specifically methylates the guanine in position
NX08_RS19105	COG2202	Pas domain
NX08_RS19105	COG2205	protein histidine kinase activity
NX08_RS19125	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
NX08_RS19130	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NX08_RS19175	COG0745	RESPONSE REGULATOR receiver
NX08_RS19190	COG1404	Belongs to the peptidase S8 family
NX08_RS19215	COG0842	Transport permease protein
NX08_RS19220	COG1131	(ABC) transporter
NX08_RS19225	COG0025	NhaP-type Na H and K H
NX08_RS19235	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
NX08_RS19240	COG1573	uracil-dna glycosylase
NX08_RS19265	COG0583	DNA-binding transcription factor activity
NX08_RS19275	COG0667	Aldo Keto reductase
NX08_RS19285	COG3590	peptidase
NX08_RS19300	COG0531	amino acid
NX08_RS19315	COG2972	Histidine kinase
NX08_RS19340	COG3685	Protein conserved in bacteria
NX08_RS19345	COG3546	catalase activity
NX08_RS19395	COG1271	oxidase subunit
NX08_RS19400	COG1294	oxidase, subunit
NX08_RS19415	COG1028	Short-chain dehydrogenase reductase Sdr
NX08_RS19420	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
NX08_RS19440	COG1132	(ABC) transporter
NX08_RS19455	COG1063	alcohol dehydrogenase
NX08_RS19510	COG1131	(ABC) transporter
NX08_RS19540	COG0038	chloride channel
NX08_RS19550	COG0024	Methionine aminopeptidase
NX08_RS19645	COG0582	viral genome integration into host DNA
NX08_RS19665	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NX08_RS19670	COG1490	D-aminoacyl-tRNA deacylase activity
NX08_RS19675	COG1560	Kdo2-lipid A biosynthetic process
NX08_RS19720	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
NX08_RS19720	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
NX08_RS19725	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
NX08_RS19730	COG0242	peptide deformylase activity
NX08_RS19735	COG1652	LysM domain
NX08_RS19740	COG0758	DNA mediated transformation
NX08_RS19760	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
NX08_RS19760	COG1754	DNA topoisomerase type I activity
NX08_RS19765	COG0009	L-threonylcarbamoyladenylate synthase
NX08_RS19780	COG1028	Short-chain dehydrogenase reductase Sdr
NX08_RS19790	COG0616	signal peptide processing
NX08_RS19795	COG0534	Mate efflux family protein
NX08_RS19815	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
NX08_RS19835	COG1252	NADH dehydrogenase
NX08_RS19840	COG2860	membrane
NX08_RS19845	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NX08_RS19850	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
NX08_RS19855	COG3437	response regulator, receiver
NX08_RS19860	COG2177	Part of the ABC transporter FtsEX involved in
NX08_RS19865	COG2884	Cell division ATP-binding protein ftsE
NX08_RS19875	COG3118	belongs to the thioredoxin family
NX08_RS19880	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
NX08_RS19890	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
NX08_RS19940	COG1518	maintenance of DNA repeat elements
NX08_RS19945	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
NX08_RS19955	COG1652	LysM domain
NX08_RS19960	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
NX08_RS19960	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
NX08_RS19975	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NX08_RS20000	COG5383	Protein conserved in bacteria
NX08_RS20040	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
NX08_RS20045	COG3023	N-Acetylmuramoyl-L-alanine amidase
NX08_RS20055	COG4948	Mandelate Racemase Muconate Lactonizing
NX08_RS20065	COG0531	amino acid
NX08_RS20080	COG4682	membrane
NX08_RS20085	COG2133	pyrroloquinoline quinone binding
NX08_RS20095	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
NX08_RS20100	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
NX08_RS20110	COG1610	YqeY-like protein
NX08_RS20115	COG1295	ribonuclease BN
NX08_RS20120	COG0358	DNA primase activity
NX08_RS20135	COG0109	protoheme IX farnesyltransferase activity
NX08_RS20165	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
NX08_RS20180	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
NX08_RS20235	COG0739	heme binding
NX08_RS20250	COG2211	Major facilitator Superfamily
NX08_RS20255	COG0708	Exodeoxyribonuclease III
NX08_RS20270	COG1192	Involved in chromosome partitioning
NX08_RS20275	COG1475	DNA binding
NX08_RS20295	COG0463	Glycosyl transferase, family 2
NX08_RS20320	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
NX08_RS20330	COG0018	arginyl-trna synthetase
NX08_RS20345	COG4221	oxidoreductase activity
NX08_RS20360	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NX08_RS20365	COG1166	arginine decarboxylase activity
NX08_RS20370	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
NX08_RS20400	COG3525	Glycosyl hydrolase, family 20, catalytic domain
NX08_RS20400	COG3291	Pkd domain containing protein
NX08_RS20445	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NX08_RS20505	COG3620	sequence-specific DNA binding
NX08_RS20585	COG4943	cyclic-guanylate-specific phosphodiesterase activity
NX08_RS20610	COG1690	Belongs to the RtcB family
NX08_RS20650	COG1090	epimerase
NX08_RS20660	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NX08_RS20680	COG0628	permease
NX08_RS20685	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NX08_RS20690	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
NX08_RS20705	COG0753	catalase activity
NX08_RS20720	COG2197	response regulator
NX08_RS20725	COG4585	Histidine kinase
NX08_RS20730	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NX08_RS20735	COG1136	(ABC) transporter
NX08_RS20785	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NX08_RS20790	COG0180	Tryptophanyl-tRNA synthetase
NX08_RS20795	COG3237	CsbD-like
NX08_RS20840	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
NX08_RS20855	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
NX08_RS20860	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
NX08_RS20860	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
NX08_RS20905	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
NX08_RS20940	COG1199	ATP-dependent helicase activity
NX08_RS20955	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
NX08_RS20975	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
NX08_RS21040	COG0625	glutathione transferase activity
NX08_RS21080	COG4555	ABC transporter
NX08_RS21095	COG1476	TRANSCRIPTIONal
NX08_RS21110	COG1230	cation diffusion facilitator family transporter
NX08_RS21115	COG0543	2 iron, 2 sulfur cluster binding
NX08_RS21115	COG0633	Ferredoxin
NX08_RS21120	COG1131	(ABC) transporter
NX08_RS21125	COG0842	Transport permease protein
NX08_RS21135	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
NX08_RS21160	COG1607	acyl-coa hydrolase
NX08_RS21180	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NX08_RS21190	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NX08_RS21205	COG0045	succinate-CoA ligase (ADP-forming) activity
NX08_RS21205	COG1042	CoA-binding domain protein
NX08_RS21205	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NX08_RS21220	COG2239	Acts as a magnesium transporter
NX08_RS21235	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
NX08_RS21240	COG3387	PFAM Glycoside hydrolase 15-related
NX08_RS21255	COG3100	YcgL domain-containing protein
NX08_RS21260	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NX08_RS21270	COG0463	Glycosyl transferase, family 2
NX08_RS21285	COG1028	Short-chain dehydrogenase reductase Sdr
NX08_RS21310	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
NX08_RS21325	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NX08_RS21400	COG1121	(ABC) transporter
NX08_RS21445	COG0408	coproporphyrinogen oxidase activity
NX08_RS21460	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
NX08_RS21555	COG0210	DNA helicase
NX08_RS21575	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NX08_RS21585	COG2159	amidohydrolase
NX08_RS21610	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NX08_RS21635	COG0357	Ribosomal RNA small subunit methyltransferase G
NX08_RS21650	COG2091	lysine biosynthetic process via aminoadipic acid
NX08_RS21665	COG0708	Exodeoxyribonuclease III
NX08_RS21670	COG1940	carbohydrate kinase activity
NX08_RS21680	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NX08_RS21690	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NX08_RS21695	COG3162	membrane
NX08_RS21755	COG1028	Short-chain dehydrogenase reductase Sdr
NX08_RS21760	COG0179	Fumarylacetoacetate (FAA) hydrolase
NX08_RS21765	COG4948	Mandelate Racemase Muconate Lactonizing
NX08_RS21770	COG3254	rhamnose metabolic process
NX08_RS21775	COG0738	Major facilitator superfamily
NX08_RS21780	COG1414	Transcriptional regulator
NX08_RS21795	COG2205	protein histidine kinase activity
NX08_RS21805	COG3459	Glycosyltransferase 36 associated
NX08_RS21810	COG2211	Major facilitator Superfamily
NX08_RS21815	COG3265	gluconokinase activity
NX08_RS21855	COG2911	Protein conserved in bacteria
NX08_RS21860	COG0729	surface antigen
NX08_RS21875	COG3293	Transposase
NX08_RS21885	COG4771	TonB-dependent receptor
NX08_RS21890	COG0457	Tetratricopeptide repeat
NX08_RS21900	COG0752	glycyl-tRNA synthetase alpha subunit
NX08_RS21905	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
NX08_RS21930	COG0519	Catalyzes the synthesis of GMP from XMP
NX08_RS21930	COG0518	GMP synthase (glutamine-hydrolyzing) activity
NX08_RS21940	COG0805	protein transport
NX08_RS21945	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NX08_RS21950	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NX08_RS21960	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
NX08_RS21980	COG2974	May be involved in recombination
NX08_RS21985	COG0037	tRNA processing
NX08_RS22005	COG3661	Belongs to the glycosyl hydrolase 67 family
NX08_RS22015	COG4948	Mandelate Racemase Muconate Lactonizing
NX08_RS22025	COG1472	Belongs to the glycosyl hydrolase 3 family
NX08_RS22030	COG0246	Mannitol dehydrogenase
NX08_RS22065	COG1904	glucuronate isomerase
NX08_RS22070	COG3693	PFAM glycoside hydrolase, family 10
NX08_RS22095	COG2211	Major facilitator Superfamily
NX08_RS22140	COG2937	Belongs to the GPAT DAPAT family
NX08_RS22170	COG0284	orotidine-5'-phosphate decarboxylase activity
NX08_RS22175	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
NX08_RS22180	COG3132	Protein of unknown function, DUF480
NX08_RS22195	COG0210	DNA helicase
NX08_RS22200	COG1435	thymidine kinase activity
NX08_RS22210	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
NX08_RS22220	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
NX08_RS22275	COG0676	glucose-6-phosphate 1-epimerase activity
NX08_RS22285	COG3012	SEC-C Motif Domain Protein
NX08_RS22290	COG0730	response to heat
NX08_RS22320	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
NX08_RS22325	COG0302	gtp cyclohydrolase
NX08_RS22340	COG1566	PFAM secretion protein HlyD family protein
NX08_RS22350	COG1289	transmembrane transporter activity
NX08_RS22355	COG0477	Major facilitator Superfamily
NX08_RS22365	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NX08_RS22410	COG0564	pseudouridine synthase activity
NX08_RS22430	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
NX08_RS22485	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
NX08_RS22490	COG1074	ATP-dependent DNA helicase activity
NX08_RS22495	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
NX08_RS22530	COG1127	ABC transporter
NX08_RS22535	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
NX08_RS22540	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
NX08_RS22555	COG2853	Lipoprotein
NX08_RS22570	COG0386	Belongs to the glutathione peroxidase family
NX08_RS22580	COG1322	Protein conserved in bacteria
NX08_RS22615	COG0531	amino acid
NX08_RS22645	COG3835	regulator
NX08_RS22650	COG1929	Belongs to the glycerate kinase type-1 family
NX08_RS22655	COG2271	Major facilitator Superfamily
NX08_RS22675	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
NX08_RS22685	COG0861	Integral membrane protein TerC family
NX08_RS22695	COG0584	glycerophosphoryl diester phosphodiesterase
NX08_RS22710	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
NX08_RS22720	COG0706	membrane insertase activity