locus-tag class description NX80_RS00015 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) NX80_RS00025 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) NX80_RS00035 ENOG4108K0D peptidase, M48 NX80_RS00065 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) NX80_RS00075 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) NX80_RS00100 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation NX80_RS00120 ENOG4105CN1 protease NX80_RS00125 ENOG41063SB peptidase NX80_RS00135 ENOG4107VAM peptidase, m28 NX80_RS00175 ENOG4105DQ4 alcohol dehydrogenase NX80_RS00190 ENOG4105BZ8 glutamate synthase NX80_RS00195 ENOG4105CBC glutamate synthase NX80_RS00280 ENOG4108I5C dEAD DEAH box helicase NX80_RS00285 ENOG4108UT2 hemolysin iii NX80_RS00345 ENOG4105K63 Thioredoxin NX80_RS00355 ENOG4105CSH Transporter NX80_RS00395 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 NX80_RS00410 ENOG4105F2I Transposase NX80_RS00420 ENOG4105CGF Aromatic amino acid aminotransferase NX80_RS00425 ENOG4105CHB tonB-dependent Receptor NX80_RS00450 ENOG4105DMF Dehydrogenase NX80_RS00570 ENOG4108YXU transcriptional regulator AsnC family NX80_RS00575 ENOG4105MIR Phenylalanine 4-monooxygenase NX80_RS00585 ENOG4107TDE lipolytic protein G-D-S-L family NX80_RS00595 ENOG4105CHR reductase NX80_RS00600 ENOG4105D50 Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate (By similarity) NX80_RS00605 ENOG4105ETE Transcriptional regulator (LacI family NX80_RS00610 ENOG4105DSG hydrolase family 43 NX80_RS00615 ENOG4105CG6 trap dicarboxylate transporter dctm subunit NX80_RS00625 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit NX80_RS00660 ENOG4105CG3 alpha amylase, catalytic region NX80_RS00665 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) NX80_RS00675 ENOG4105D5K Hemolysin activator protein NX80_RS00680 ENOG4105CKT filamentous hemagglutinin NX80_RS00695 ENOG4105CKT filamentous hemagglutinin NX80_RS00730 ENOG4105CVE Lytic murein transglycosylase NX80_RS00735 ENOG4105D78 K07001 NTE family protein NX80_RS00740 ENOG4105CH2 amidohydrolase NX80_RS00750 ENOG4105DKW ABC transporter NX80_RS00765 ENOG4108IJ8 ABC transporter NX80_RS00770 ENOG4105E90 ABC transporter NX80_RS00815 ENOG4105D1F ATP-binding protein NX80_RS00820 ENOG4105M4E phosphohistidine phosphatase, SixA NX80_RS00830 ENOG4107RZC phospholipase d NX80_RS00835 ENOG4105KA0 thioesterase Superfamily protein NX80_RS00885 ENOG4105C5F glutamine synthetase NX80_RS00895 ENOG4105BZU Histidine kinase NX80_RS00900 ENOG4105CUX Signal transduction histidine kinase NX80_RS00905 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family NX80_RS00910 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) NX80_RS00915 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) NX80_RS00925 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) NX80_RS00935 ENOG4105CHU acetyl-coa acetyltransferase NX80_RS00975 ENOG4107YZP Rhodanese domain protein NX80_RS00980 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) NX80_RS00985 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase NX80_RS00995 ENOG4105C7K acetolactate synthase NX80_RS01000 ENOG4108TQ9 Histidine kinase NX80_RS01005 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family NX80_RS01025 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) NX80_RS01040 ENOG4105E2T synthase III NX80_RS01045 ENOG4107R3N Filamentation induced by cAMP protein fic NX80_RS01050 ENOG4108J2P Alpha beta hydrolase fold NX80_RS01055 ENOG4105PI0 Ferredoxin NX80_RS01060 ENOG410680H amp-dependent synthetase and ligase NX80_RS01065 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase NX80_RS01085 ENOG4105CPF Cell wall formation (By similarity) NX80_RS01105 ENOG4105DR9 pseudouridine synthase NX80_RS01115 ENOG4108YZN class I peptide chain release factor NX80_RS01125 ENOG4105D44 asparaginase NX80_RS01130 ENOG4105DGW oligopeptidase A NX80_RS01165 ENOG4107R11 Transcriptional regulator NX80_RS01170 ENOG4107QP3 malate synthase g NX80_RS01180 ENOG4105F2I Transposase NX80_RS01185 ENOG4105BZU Histidine kinase NX80_RS01215 ENOG4107QX3 carboxylase NX80_RS01220 ENOG4105C1G acyl-Coa dehydrogenase NX80_RS01275 ENOG4105CKI cobalamin synthesis protein NX80_RS01295 ENOG4105D6Z AFG1 family ATPase NX80_RS01305 ENOG4105K56 Transcriptional regulator NX80_RS01310 ENOG4108ZHJ Organic hydroperoxide resistance protein NX80_RS01335 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein NX80_RS01350 ENOG4108R99 pseudouridine synthase NX80_RS01360 ENOG4105CQ7 ATP-dependent helicase NX80_RS01365 ENOG4108W15 Protein of unknown function (DUF1456) NX80_RS01370 ENOG4105VT2 5-hydroxyisourate hydrolase NX80_RS01375 ENOG4105E1J oxidoreductase NX80_RS01395 ENOG4105C5R Aminotransferase NX80_RS01420 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) NX80_RS01445 ENOG4105C7N Xanthine uracil vitamin C permease NX80_RS01460 ENOG4105ETT transcriptional Regulator, LysR family NX80_RS01465 ENOG4105F8V Hydrolase, tatD family NX80_RS01500 ENOG4106NZI LysR family Transcriptional regulator NX80_RS01505 ENOG4105D94 Major Facilitator Superfamily NX80_RS01510 ENOG4105EMU Dehydrogenase NX80_RS01520 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) NX80_RS01525 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase NX80_RS01550 ENOG4105E3W Two component transcriptional regulator (Winged helix family NX80_RS01570 ENOG4105WPN DNA integration recombination invertion protein NX80_RS01575 ENOG4105DZ2 Transcriptional regulator NX80_RS01580 ENOG4108UZX fmn reductase NX80_RS01590 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) NX80_RS01610 ENOG4105ECR NmrA family NX80_RS01670 ENOG4105C01 Dihydroxy-acid dehydratase NX80_RS01685 ENOG4108Z0R Transferase NX80_RS01695 ENOG4105D2S major facilitator superfamily NX80_RS01700 ENOG4105CPI Metal Dependent Phosphohydrolase NX80_RS01730 ENOG41072AC 4-hydroxybenzoate 3-monooxygenase NX80_RS01740 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) NX80_RS01745 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) NX80_RS01750 ENOG4105C6V Glycerol-3-phosphate dehydrogenase NX80_RS01755 ENOG4105E98 transcriptional regulator DeoR family NX80_RS01780 ENOG4105CHU acetyl-coa acetyltransferase NX80_RS01795 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase NX80_RS01800 ENOG4105F2Z 3-oxoadipate enol-lactonase NX80_RS01805 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase NX80_RS01810 ENOG4107HP6 Transcriptional regulator NX80_RS01825 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) NX80_RS01865 ENOG4107EXU Short-chain dehydrogenase reductase Sdr NX80_RS01880 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) NX80_RS01890 ENOG41081UC Inherit from COG: Competence protein NX80_RS01925 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) NX80_RS01990 ENOG4105VS8 Flagellar biosynthetic protein fliq NX80_RS02010 ENOG4108HR8 type iii secretion NX80_RS02030 ENOG4107Y59 type iii secretion NX80_RS02045 ENOG4108JIR Flagellum-specific ATP synthase NX80_RS02070 ENOG4105FTC Lytic transglycosylase catalytic NX80_RS02090 ENOG4105EGS Mechanosensitive ion channel NX80_RS02095 ENOG4107RES phosphoglycerol transferase I NX80_RS02110 ENOG4105CKW Inner membrane protein yedI NX80_RS02125 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) NX80_RS02130 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) NX80_RS02135 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) NX80_RS02160 ENOG4105K4T epimerase NX80_RS02165 ENOG41090TK Short-chain dehydrogenase reductase Sdr NX80_RS02195 ENOG4105C1J atp-dependent rna helicase NX80_RS02210 ENOG4105C7S Dehydrogenase NX80_RS02220 ENOG4105CPP Dehydrogenase, E1 component NX80_RS02225 ENOG4107RUY (E1 component), alpha subunit NX80_RS02255 ENOG4105DUX Transporter NX80_RS02270 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase NX80_RS02275 ENOG4105F1J Homogentisate 1,2-dioxygenase NX80_RS02330 ENOG4105KJM monovalent cation h antiporter subunit g NX80_RS02335 ENOG4105W4C monovalent cation H antiporter subunit F NX80_RS02345 ENOG4107R4Z monovalent cation h antiporter subunit d NX80_RS02350 ENOG4108ZE9 Monovalent cation H antiporter subunit C NX80_RS02355 ENOG4105D65 subunit l NX80_RS02455 ENOG4105DGW oligopeptidase A NX80_RS02480 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) NX80_RS02485 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) NX80_RS02500 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) NX80_RS02510 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase NX80_RS02520 ENOG4105C1J atp-dependent rna helicase NX80_RS02535 ENOG4108RXX maleylacetoacetate isomerase NX80_RS02540 ENOG4105CZX twitching motility protein NX80_RS02565 ENOG4105C28 cystathionine NX80_RS02580 ENOG4105EY8 ABC transporter NX80_RS02590 ENOG4108DMA Nad-dependent epimerase dehydratase NX80_RS02595 ENOG4105C0K Gdp-mannose 4,6-dehydratase NX80_RS02600 ENOG4108PQP glycosyl transferase group 1 NX80_RS02645 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) NX80_RS02655 ENOG4105IQ5 FAD linked oxidase domain protein NX80_RS02670 ENOG4105C10 Electron transfer flavoprotein NX80_RS02675 ENOG4105BZJ Electron transfer flavoprotein NX80_RS02690 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase NX80_RS02700 ENOG4105CJT Mannose-1-phosphate guanylyltransferase NX80_RS02705 ENOG4107QKV phosphomannomutase NX80_RS02725 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase NX80_RS02745 ENOG4108SNX Mammalian cell entry related domain protein NX80_RS02750 ENOG4105DHJ ABC, transporter NX80_RS02765 ENOG4105VFQ Histone family protein nucleoid-structuring protein H-NS NX80_RS02780 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase NX80_RS02790 ENOG4105KEG ribosomal-protein-alanine acetyltransferase NX80_RS02795 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) NX80_RS02815 ENOG4108Z33 Thiol disulfide Interchange Protein NX80_RS02825 ENOG4106RE7 Cytochrome NX80_RS02830 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) NX80_RS02855 ENOG4105JJR Histidine kinase NX80_RS02880 ENOG4108QBQ Catalyzes the condensation of formaldehyde and glutathione to S-hydroxymethylglutathione (By similarity) NX80_RS02935 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) NX80_RS02940 ENOG41069H0 dihydroorotase EC 3.5.2.3 NX80_RS02975 ENOG4105CHM Aminotransferase NX80_RS02980 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) NX80_RS02995 ENOG4107QW3 Sucrose phosphorylase NX80_RS03015 ENOG4105ETE Transcriptional regulator (LacI family NX80_RS03020 ENOG4105CHR reductase NX80_RS03025 ENOG4105D4T Citrate transporter NX80_RS03050 ENOG4105DHQ Histidine kinase NX80_RS03060 ENOG4105WH1 Two component transcriptional regulator luxr family NX80_RS03075 ENOG4105CPC Aldo Keto reductase NX80_RS03080 ENOG4105F04 LysR family Transcriptional regulator NX80_RS03090 ENOG4105CSH Transporter NX80_RS03105 ENOG4105CK2 sodium dicarboxylate symporter NX80_RS03110 ENOG4105C6K Malic enzyme NX80_RS03205 ENOG4105D1S lipid A biosynthesis NX80_RS03210 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase NX80_RS03215 ENOG4105DFG type I secretion outer membrane protein NX80_RS03220 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) NX80_RS03230 ENOG4105BZU Histidine kinase NX80_RS03240 ENOG4108MP6 LysR family Transcriptional regulator NX80_RS03245 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) NX80_RS03250 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) NX80_RS03260 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) NX80_RS03265 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) NX80_RS03270 ENOG4105C7B Threonine dehydratase NX80_RS03295 ENOG4105C8Q Methyl-accepting chemotaxis NX80_RS03315 ENOG4108M3R transcriptional activator CadC NX80_RS03320 ENOG4105ECQ AraC Family Transcriptional Regulator NX80_RS03325 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) NX80_RS03335 ENOG4105F0N pyrophosphate phospho-hydrolase NX80_RS03345 ENOG4105EAY pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for NX80_RS03365 ENOG4105DFU Cell wall formation (By similarity) NX80_RS03375 ENOG4105FFC UPF0187 protein NX80_RS03380 ENOG410841Q phosphoesterase PA-phosphatase related protein NX80_RS03390 ENOG41061TZ Short-chain dehydrogenase reductase Sdr NX80_RS03400 ENOG4105EYW Ion transport protein NX80_RS03405 ENOG4105C8Y Acetylornithine aminotransferase NX80_RS03435 ENOG4105CIH Imidazole acetol-phosphate transaminase NX80_RS03440 ENOG41090JD Blue (Type 1) copper domain protein NX80_RS03445 ENOG41061ZR Transcriptional regulator NX80_RS03475 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) NX80_RS03480 ENOG4105VCQ rubredoxin NX80_RS03485 ENOG41063JG Transcriptional regulator NX80_RS03505 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase NX80_RS03515 ENOG4105W8B Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) NX80_RS03530 ENOG4107RAQ aminopeptidase NX80_RS03540 ENOG4105D9Y Splits dipeptides with a prolyl residue in the C- terminal position (By similarity) NX80_RS03555 ENOG4105CSA Coproporphyrinogen iii oxidase NX80_RS03570 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) NX80_RS03575 ENOG4105DSJ YicC domain protein NX80_RS03580 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) NX80_RS03590 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) NX80_RS03595 ENOG4105KME endoribonuclease L-psp NX80_RS03600 ENOG4105CB5 ATP-dependent DNA helicase recG NX80_RS03605 ENOG4105DU0 nucleoside hydrolase NX80_RS03615 ENOG4105BZN citrate synthase NX80_RS03625 ENOG4108JQC penicillin-binding protein 1A NX80_RS03650 ENOG4105E4G Type IV pilus NX80_RS03655 ENOG4105C7R Atpase associated with various cellular activities aaa_3 NX80_RS03675 ENOG4107QVM von Willebrand factor, type A NX80_RS03690 ENOG4105CK2 sodium dicarboxylate symporter NX80_RS03695 ENOG4105CV1 Transketolase (EC 2.2.1.1) NX80_RS03705 ENOG4105CNM Receptor NX80_RS03710 ENOG4105CBN LysR family transcriptional regulator NX80_RS03715 ENOG4105CHR reductase NX80_RS03720 ENOG4105DR5 peptidase NX80_RS03725 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein NX80_RS03760 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) NX80_RS03765 ENOG4105E0C molybdate abc transporter NX80_RS03770 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein NX80_RS03775 ENOG4107S76 domain protein NX80_RS03785 ENOG4105EIF outer membrane protein W NX80_RS03805 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase NX80_RS03840 ENOG4105CA9 Pyruvate kinase NX80_RS03850 ENOG4107R1Y fructose-bisphosphate aldolase NX80_RS03855 ENOG4108UVJ appr-1-p processing domain protein NX80_RS03875 ENOG4107R11 Transcriptional regulator NX80_RS03890 ENOG4105BZU Histidine kinase NX80_RS03915 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) NX80_RS03920 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) NX80_RS03930 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) NX80_RS03940 ENOG4105BZS acriflavin resistance protein NX80_RS04000 ENOG4105C2N RNA methyltransferase TrmH family group 3 NX80_RS04045 ENOG4105ETE Transcriptional regulator (LacI family NX80_RS04055 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) NX80_RS04080 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) NX80_RS04085 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) NX80_RS04160 ENOG4105ETX regulatoR NX80_RS04165 ENOG4105BZU Histidine kinase NX80_RS04190 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) NX80_RS04195 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) NX80_RS04215 ENOG4107QHF type ii secretion system protein e NX80_RS04220 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family NX80_RS04225 ENOG4107TUY Histidine kinase NX80_RS04230 ENOG4105CMV Succinyl-CoA synthetase subunit beta NX80_RS04235 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha NX80_RS04250 ENOG4105C4K Nad synthetase NX80_RS04275 ENOG4107QMP dna polymerase iii subunits gamma and tau NX80_RS04280 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) NX80_RS04290 ENOG4105K59 histidine triad (HIT) protein NX80_RS04300 ENOG4105F8C transglutaminase domain-containing protein NX80_RS04310 ENOG4105C7R Atpase associated with various cellular activities aaa_3 NX80_RS04330 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein NX80_RS04340 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) NX80_RS04350 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase NX80_RS04355 ENOG4105CHR reductase NX80_RS04365 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) NX80_RS04375 ENOG4105HHA aminodeoxychorismate lyase NX80_RS04380 ENOG4107QRG dna polymerase iii NX80_RS04395 ENOG4105KRQ Addiction module toxin, Txe YoeB family NX80_RS04400 ENOG4105VTW prevent-host-death family NX80_RS04410 ENOG4108JU7 Transcriptional regulator NX80_RS04415 ENOG4105CR4 methylisocitrate lyase NX80_RS04425 ENOG4105BZN citrate synthase NX80_RS04430 ENOG4108I0Z Aconitate hydratase NX80_RS04440 ENOG4105C7F AcnD-accessory protein PrpF NX80_RS04460 ENOG4105DN3 alpha-2-macroglobulin domain protein NX80_RS04480 ENOG4108JQB penicillin-binding protein 1C NX80_RS04505 ENOG4105M3Z response regulator NX80_RS04510 ENOG4107QJR hflk protein NX80_RS04515 ENOG4105EPW hflc protein NX80_RS04520 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis NX80_RS04525 ENOG4105CD8 aminopeptidase N NX80_RS04570 ENOG4107SCJ type I restriction enzyme EcoKI subunit R NX80_RS04615 ENOG4107Z4K Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) NX80_RS04625 ENOG4105BZP glycoside hydrolase 15-related NX80_RS04645 ENOG4105F2I Transposase NX80_RS04675 ENOG4105CWX Alpha-1,2-mannosidase NX80_RS04680 ENOG4107GJV short-chain dehydrogenase reductase NX80_RS04700 ENOG4105BZU Histidine kinase NX80_RS04740 ENOG4105C7W Xanthine dehydrogenase NX80_RS04745 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding NX80_RS04750 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit NX80_RS04835 ENOG4105EPD Oligopeptide transporter, Opt family NX80_RS04855 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein NX80_RS04885 ENOG4106AXJ AraC family transcriptional regulator NX80_RS04970 ENOG4105CV8 reductase NX80_RS04980 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor NX80_RS04995 ENOG4108JJA ABC, transporter NX80_RS05000 ENOG4105C2C drug resistance transporter, Bcr CflA NX80_RS05015 ENOG4105DIJ Phosphoethanolamine transferase NX80_RS05030 ENOG4105ETX regulatoR NX80_RS05035 ENOG4105DHQ Histidine kinase NX80_RS05050 ENOG4107QMS site-determining protein NX80_RS05055 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) NX80_RS05065 ENOG4105BZU Histidine kinase NX80_RS05070 ENOG4105WH1 Two component transcriptional regulator luxr family NX80_RS05130 ENOG4105DWA May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate NX80_RS05160 ENOG4105C29 acyl-CoA thioesterase NX80_RS05175 ENOG4108TGP Thioesterase superfamily protein NX80_RS05180 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) NX80_RS05185 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) NX80_RS05205 ENOG4105CJR Integral membrane protein (MviN NX80_RS05210 ENOG4105DTN riboflavin biosynthesis protein ribF NX80_RS05215 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) NX80_RS05220 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) NX80_RS05235 ENOG4105E2S oxidase) subunit II NX80_RS05240 ENOG4105BZ9 Cytochrome C oxidase, subunit I NX80_RS05245 ENOG4105CCU oxidase (Subunit III) NX80_RS05250 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) NX80_RS05260 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) NX80_RS05265 ENOG4105KAF membrAne NX80_RS05285 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) NX80_RS05295 ENOG4107MMM Anti-sigma-factor antagonist NX80_RS05300 ENOG4105FUA antagonist NX80_RS05305 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase NX80_RS05315 ENOG4105BZU Histidine kinase NX80_RS05340 ENOG4105KCV RNA signal recognition particle 4.5S RNA NX80_RS05345 ENOG4105C08 Histidine kinase NX80_RS05350 ENOG4107Z5C methylesterase NX80_RS05355 ENOG4105BZU Histidine kinase NX80_RS05360 ENOG4105BZU Histidine kinase NX80_RS05375 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) NX80_RS05380 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) NX80_RS05385 ENOG4105CRE cytochrome C NX80_RS05390 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY NX80_RS05400 ENOG4105EA8 2-Nitropropane dioxygenase NX80_RS05405 ENOG4105CM2 brancheD-chain amino acid aminotransferase NX80_RS05410 ENOG4105K5M 30s ribosomal protein S16 NX80_RS05415 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) NX80_RS05420 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) NX80_RS05430 ENOG4107QJQ Mate efflux family protein NX80_RS05435 ENOG4105VEJ Heat shock protein NX80_RS05440 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) NX80_RS05455 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) NX80_RS05465 ENOG41061TZ Short-chain dehydrogenase reductase Sdr NX80_RS05470 ENOG41061TZ Short-chain dehydrogenase reductase Sdr NX80_RS05475 ENOG41061TZ Short-chain dehydrogenase reductase Sdr NX80_RS05490 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) NX80_RS05505 ENOG4105CNT hydrolase family 2 NX80_RS05510 ENOG4106FKC arabinogalactan endo-1,4-beta-galactosidase NX80_RS05525 ENOG4105C26 Dehydrogenase NX80_RS05530 ENOG4105C1G acyl-Coa dehydrogenase NX80_RS05535 ENOG4105E39 Enoyl-CoA hydratase NX80_RS05540 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase NX80_RS05545 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase NX80_RS05560 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase NX80_RS05565 ENOG4105EMN RNA polymerase sigma factor NX80_RS05575 ENOG4105C0H protease NX80_RS05585 ENOG4105C3F Signal peptidase i NX80_RS05595 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) NX80_RS05600 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) NX80_RS05630 ENOG4108QDE fad dependent oxidoreductase NX80_RS05635 ENOG4105EXX Deoxyribodipyrimidine photolyase-related protein NX80_RS05640 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) NX80_RS05645 ENOG4108UGV hypoxanthine phosphoribosyltransferase NX80_RS05650 ENOG4107RHB Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity) NX80_RS05655 ENOG4105VEQ Cold shock protein NX80_RS05660 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) NX80_RS05675 ENOG4107QRT dEAD DEAH box helicase NX80_RS05680 ENOG4107T0X DNA ligase NX80_RS05690 ENOG4107T0X DNA ligase NX80_RS05705 ENOG4108K0B C-di-gmp phosphodiesterase NX80_RS05725 ENOG4105CHU acetyl-coa acetyltransferase NX80_RS05745 ENOG4108VKG metal-dependent hydrolase NX80_RS05765 ENOG4105KSC Transcriptional regulator, TraR DksA family NX80_RS05795 ENOG4105DFF Rod shape-determining protein mreb NX80_RS05800 ENOG4108YZY peptidylprolyl cis-trans isomerase NX80_RS05815 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA NX80_RS05830 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase NX80_RS05835 ENOG4105F27 Major Facilitator NX80_RS05880 ENOG4105M4H endoribonuclease L-psp NX80_RS05885 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase NX80_RS05900 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase NX80_RS05925 ENOG4105K6V RNA polymerase NX80_RS05940 ENOG4108R3D Electron transport complex NX80_RS05950 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) NX80_RS05960 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase NX80_RS05965 ENOG4108IQI permease NX80_RS05970 ENOG4107QK5 Homocysteine s-methyltransferase NX80_RS06025 ENOG4108YXA Membrane NX80_RS06030 ENOG4105NRM Membrane NX80_RS06045 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) NX80_RS06060 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) NX80_RS06065 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) NX80_RS06070 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) NX80_RS06075 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) NX80_RS06080 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) NX80_RS06090 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane NX80_RS06095 ENOG4105DZP Membrane-associated zinc metalloprotease NX80_RS06105 ENOG4105KNE Phosphatidate cytidylyltransferase NX80_RS06120 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) NX80_RS06125 ENOG4105BZU Histidine kinase NX80_RS06130 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) NX80_RS06170 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) NX80_RS06175 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) NX80_RS06190 ENOG4105KUZ arsenate reductase NX80_RS06205 ENOG4105CAQ asparagine synthetase NX80_RS06215 ENOG4108ESX Receptor NX80_RS06225 ENOG4108UWD Iron-storage protein NX80_RS06235 ENOG4105FQ6 thiopurine methyltransferase NX80_RS06245 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) NX80_RS06265 ENOG4105CW7 secretion protein, HlyD family NX80_RS06270 ENOG4105C0R drug resistance transporter emrb qaca subfamily NX80_RS06345 ENOG4105DGW oligopeptidase A NX80_RS06360 ENOG4105DP0 ferredoxin-NADP reductase NX80_RS06370 ENOG4107GFK fumarate NX80_RS06400 ENOG4105HDD phospholipase NX80_RS06410 ENOG4105VEQ Cold shock protein NX80_RS06425 ENOG4105CUZ uba thif-type nad fad binding protein NX80_RS06430 ENOG4105F8V Hydrolase, tatD family NX80_RS06450 ENOG4105C1G acyl-Coa dehydrogenase NX80_RS06460 ENOG4108K3A Glutathione S-transferase NX80_RS06470 ENOG4105CAQ asparagine synthetase NX80_RS06480 ENOG4105CDU Replicative dna helicase NX80_RS06485 ENOG4105CVP deoxyribo-dipyrimidine photolyase NX80_RS06495 ENOG4105CDV Ompa motb domain protein NX80_RS06500 ENOG4105CR8 Transcriptional regulator NX80_RS06515 ENOG4105C1P efflux transporter, rnd family, mfp subunit NX80_RS06535 ENOG4105BZU Histidine kinase NX80_RS06545 ENOG4105BZU Histidine kinase NX80_RS06635 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) NX80_RS06640 ENOG41090R7 Ferric uptake NX80_RS06645 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) NX80_RS06650 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) NX80_RS06655 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ NX80_RS06660 ENOG4105CFG Acts as a chaperone (By similarity) NX80_RS06665 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) NX80_RS06700 ENOG4105C5Q Transcriptional regulator NX80_RS06710 ENOG4105BZ1 (ABC) transporter NX80_RS06720 ENOG4108URH decarboxylase NX80_RS06730 ENOG4105C7S Dehydrogenase NX80_RS06735 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 NX80_RS06745 ENOG4105EZE Cupin 4 family protein NX80_RS06770 ENOG4107QTF adenylosuccinate lyase NX80_RS06780 ENOG4105C37 (CBS) domain NX80_RS06810 ENOG4105CZV ABC transporter NX80_RS06815 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family NX80_RS06830 ENOG4108V1T peptidylprolyl cis-trans isomerase NX80_RS06835 ENOG4105C6Y Udp-glucose 6-dehydrogenase NX80_RS06860 ENOG4105ETE Transcriptional regulator (LacI family NX80_RS06870 ENOG4105D7K pfkb domain protein NX80_RS06885 ENOG4105C3R Methionine synthase NX80_RS06890 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) NX80_RS06895 ENOG4105C1G acyl-Coa dehydrogenase NX80_RS06915 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) NX80_RS06925 ENOG4105C2N RNA methyltransferase TrmH family group 3 NX80_RS06930 ENOG4105BZU Histidine kinase NX80_RS06935 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) NX80_RS06945 ENOG4108UTW Plays a role in the regulation of phosphate uptake NX80_RS06950 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) NX80_RS06955 ENOG4105E2Z phosphate ABC transporter (Permease NX80_RS06960 ENOG4105C8U phosphate abc transporter NX80_RS06965 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) NX80_RS06990 ENOG4107B2H carbonic anhydrase NX80_RS06995 ENOG4105CHH sulfate transporter NX80_RS07000 ENOG4105CSM endonuclease III NX80_RS07010 ENOG4105E39 Enoyl-CoA hydratase NX80_RS07015 ENOG4108V1T peptidylprolyl cis-trans isomerase NX80_RS07020 ENOG4105P8F nudix hydrolase NX80_RS07025 ENOG4105KHC sulfurtransferase NX80_RS07065 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) NX80_RS07070 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) NX80_RS07085 ENOG4105CPC Aldo Keto reductase NX80_RS07095 ENOG4105CJB Exodeoxyribonuclease I NX80_RS07100 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) NX80_RS07105 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) NX80_RS07120 ENOG41077A9 carbonic anhydrase NX80_RS07145 ENOG4105C5S asparaginyl-tRNA synthetase NX80_RS07150 ENOG4108YX9 iron--sulfur cluster insertion protein erpA NX80_RS07175 ENOG4107NPY receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity) NX80_RS07185 ENOG4105CIH Imidazole acetol-phosphate transaminase NX80_RS07190 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) NX80_RS07195 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) NX80_RS07210 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) NX80_RS07215 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) NX80_RS07220 ENOG4105DZG Dehydrogenase NX80_RS07245 ENOG4105CGP Urocanate hydratase NX80_RS07255 ENOG4105C84 Histidine ammonia-lyase NX80_RS07295 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) NX80_RS07300 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) NX80_RS07305 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) NX80_RS07315 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase NX80_RS07330 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) NX80_RS07340 ENOG4105CC0 LysR family Transcriptional regulator NX80_RS07445 ENOG4105D7A ATP-binding protein NX80_RS07455 ENOG4105DJ4 phosphatidylserine decarboxylase NX80_RS07460 ENOG4105DJ4 phosphatidylserine decarboxylase NX80_RS07470 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) NX80_RS07480 ENOG4105C5I Dehydrogenase NX80_RS07485 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) NX80_RS07505 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) NX80_RS07510 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase NX80_RS07520 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) NX80_RS07545 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) NX80_RS07560 ENOG4105BZU Histidine kinase NX80_RS07585 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr NX80_RS07590 ENOG4105CP7 Triose-phosphate isomerase NX80_RS07605 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain NX80_RS07615 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain NX80_RS07625 ENOG4105GKE subunit e NX80_RS07630 ENOG4107QIZ NADH dehydrogenase NX80_RS07635 ENOG4108IEH NADH dehydrogenase subunit g NX80_RS07645 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) NX80_RS07650 ENOG4105DF2 NADH dehydrogenase subunit j NX80_RS07660 ENOG4105D65 subunit l NX80_RS07665 ENOG4105C8S subunit m NX80_RS07670 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) NX80_RS07680 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) NX80_RS07685 ENOG4105CHV Transcription elongation factor NusA NX80_RS07690 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) NX80_RS07695 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) NX80_RS07720 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase NX80_RS07730 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) NX80_RS07735 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit NX80_RS07740 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) NX80_RS07745 ENOG4105M2J Glutaredoxin NX80_RS07755 ENOG41076UM multiple antibiotic resistance (MarC)-related protein NX80_RS07760 ENOG4108KPZ tonB-dependent Receptor NX80_RS07765 ENOG4105EWT decarboxylase family NX80_RS07770 ENOG4108HRK Histidine kinase NX80_RS07775 ENOG4105X0D Fimbrial protein NX80_RS07815 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) NX80_RS07830 ENOG4108ISG Major Facilitator NX80_RS07850 ENOG4105C9M aspartyl-trna synthetase NX80_RS07870 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) NX80_RS07880 ENOG4105DFH Transport of potassium into the cell (By similarity) NX80_RS07890 ENOG4107YD3 Thioesterase NX80_RS07895 ENOG4105E02 MotA TolQ exbB proton channel NX80_RS07910 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) NX80_RS07915 ENOG4105KCK Peptidoglycan-associated lipoprotein NX80_RS07925 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) NX80_RS08275 ENOG4105C9U ATP-dependent DNA helicase RecQ NX80_RS08285 ENOG4105CQ7 ATP-dependent helicase NX80_RS08300 ENOG4105CHC glucokinase (EC 2.7.1.2) NX80_RS08330 ENOG41086XE Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ (By similarity) NX80_RS08335 ENOG4105JIE May be involved in the transport of PQQ or its precursor to the periplasm (By similarity) NX80_RS08340 ENOG410698T Required for coenzyme pyrroloquinoline quinone (PQQ) biosynthesis. PQQ is probably formed by cross-linking a specific glutamate to a specific tyrosine residue and excising these residues from the peptide (By similarity) NX80_RS08345 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) NX80_RS08370 ENOG4105BZ4 penicillin-binding protein NX80_RS08380 ENOG4105DVT helicase NX80_RS08385 ENOG41072GX Peptidase M22 Glycoprotease NX80_RS08390 ENOG41065RQ ADP-ribosylation crystallin J1 NX80_RS08400 ENOG4105D7Z glutathione synthase NX80_RS08405 ENOG4108UNF response regulator NX80_RS08410 ENOG4105M3Z response regulator NX80_RS08420 ENOG4105C8Q Methyl-accepting chemotaxis NX80_RS08445 ENOG4105D9U N-acetyltransferase NX80_RS08470 ENOG4106N3A copper homeostasis protein cutc NX80_RS08510 ENOG4105CWX Alpha-1,2-mannosidase NX80_RS08565 ENOG4108JJA ABC, transporter NX80_RS08610 ENOG4105VRS hydrolase family 18 NX80_RS08625 ENOG4105CHC glucokinase (EC 2.7.1.2) NX80_RS08630 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) NX80_RS08640 ENOG4107RK2 ADP-ribose diphosphatase NudE NX80_RS08645 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase NX80_RS08650 ENOG4105DXN mazG family NX80_RS08655 ENOG4105KK4 UPF0060 membrane protein NX80_RS08670 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) NX80_RS08675 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) NX80_RS08715 ENOG4107QPN acyl-Coa dehydrogenase NX80_RS08725 ENOG4108IG5 Transcriptional regulator NX80_RS08730 ENOG4105D05 Receptor NX80_RS08740 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) NX80_RS08775 ENOG4108UT2 hemolysin iii NX80_RS08780 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) NX80_RS08785 ENOG4105DR5 peptidase NX80_RS08790 ENOG4106TYC homoserine o-acetyltransferase (EC 2.3.1.31) NX80_RS08795 ENOG4105C28 cystathionine NX80_RS08800 ENOG4105CFH Aspartokinase NX80_RS08810 ENOG4105EJQ L-serine dehydratase NX80_RS08840 ENOG4108YYC ycei family NX80_RS08845 ENOG4105BZU Histidine kinase NX80_RS08850 ENOG4105BZU Histidine kinase NX80_RS08855 ENOG4105BZU Histidine kinase NX80_RS08860 ENOG4105BZU Histidine kinase NX80_RS08865 ENOG4105C0R drug resistance transporter emrb qaca subfamily NX80_RS08870 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) NX80_RS08885 ENOG4105D49 3-dehydroquinate synthase NX80_RS08890 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) NX80_RS08895 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) NX80_RS08905 ENOG4108P9J Phage shock protein A NX80_RS08930 ENOG4106032 Glutathionylspermidine synthase NX80_RS08945 ENOG4108Z4X TRANSCRIPTIONal NX80_RS09005 ENOG4106N2S NX80_RS09015 ENOG4105CUB amino acid NX80_RS09035 ENOG4105C85 amino acid NX80_RS09045 ENOG4105C4M (Ubiquinol oxidase) subunit I NX80_RS09050 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii NX80_RS09060 ENOG4107UWA esterase NX80_RS09065 ENOG4105CJW magnesium transporter NX80_RS09075 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) NX80_RS09080 ENOG41080Z8 PHOSPHOCARRIER protein NX80_RS09090 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) NX80_RS09100 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN NX80_RS09105 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA NX80_RS09110 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) NX80_RS09115 ENOG4108IUZ ABC transporter NX80_RS09120 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA NX80_RS09130 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase NX80_RS09135 ENOG4105C2X Arabinose 5-phosphate isomerase NX80_RS09145 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) NX80_RS09170 ENOG4108V3E phosphoribosylglycinamide formyltransferase NX80_RS09180 ENOG4105CXB phosphoribosylaminoimidazole synthetase NX80_RS09190 ENOG4105C02 permease NX80_RS09205 ENOG4108S0S Nucleotidyl transferase NX80_RS09210 ENOG4105EHM Aminoglycoside phosphotransferase NX80_RS09220 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) NX80_RS09225 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein NX80_RS09230 ENOG41090B9 response to stress NX80_RS09235 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) NX80_RS09240 ENOG4105CJ2 (LipO)protein NX80_RS09265 ENOG4107E2E PKHD-type hydroxylase NX80_RS09270 ENOG4108ESX Receptor NX80_RS09275 ENOG4105VQD rieske 2fe-2S domain-containing protein NX80_RS09280 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) NX80_RS09290 ENOG4105C9B Cysteine desulfurase NX80_RS09295 ENOG4105JRK feS assembly protein SufD NX80_RS09300 ENOG4105C3K feS assembly ATPase SufC NX80_RS09320 ENOG4108Z0Z intracellular protease Pfpi family NX80_RS09340 ENOG4108K5P (LipO)protein NX80_RS09350 ENOG4105II7 pyrroline-5-carboxylate reductase NX80_RS09355 ENOG4105DFA alanine racemase domain protein NX80_RS09360 ENOG4105CZX twitching motility protein NX80_RS09365 ENOG4105CZX twitching motility protein NX80_RS09380 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) NX80_RS09390 ENOG4108UJU UPF0301 protein NX80_RS09395 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) NX80_RS09400 ENOG4105CXT aspartate transcarbamylase NX80_RS09460 ENOG4105JAB phenazine biosynthesis protein, phzf family NX80_RS09465 ENOG4105JAB phenazine biosynthesis protein, phzf family NX80_RS09470 ENOG4105CFH Aspartokinase NX80_RS09495 ENOG4105EAH synthase NX80_RS09500 ENOG4108UUM single-stranded DNA-binding protein NX80_RS09515 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit NX80_RS09520 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding NX80_RS09525 ENOG4105C7W Xanthine dehydrogenase NX80_RS09530 ENOG4107XAN XdhC and CoxI family NX80_RS09565 ENOG4105VCD cytoplasmic protein NX80_RS09570 ENOG4105D22 carbon starvation protein NX80_RS09575 ENOG4105EUB pirin domain protein NX80_RS09595 ENOG4105EUB pirin domain protein NX80_RS09605 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) NX80_RS09615 ENOG4105C9K Endothelin-converting enzyme 1 NX80_RS09620 ENOG4107RZC phospholipase d NX80_RS09630 ENOG4105BZU Histidine kinase NX80_RS09635 ENOG4105BZU Histidine kinase NX80_RS09640 ENOG4108V3W Chemotaxis protein, CheW NX80_RS09650 ENOG4105CBS Chea signal transduction histidine kinase NX80_RS09660 ENOG4108JA2 transcriptioN-repair coupling factor NX80_RS09670 ENOG4105D6S protein involved in catabolism of external DNA NX80_RS09675 ENOG4105E3W Two component transcriptional regulator (Winged helix family NX80_RS09685 ENOG4105EB3 Histidine kinase NX80_RS09695 ENOG4105CT7 inner membrane cred family protein NX80_RS09720 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) NX80_RS09725 ENOG4105MYN Zinc uptake regulation protein NX80_RS09735 ENOG4105C1P efflux transporter, rnd family, mfp subunit NX80_RS09740 ENOG4105BZS acriflavin resistance protein NX80_RS09745 ENOG4105ENJ RND efflux system, outer membrane lipoprotein NX80_RS09760 ENOG4105F2I Transposase NX80_RS09775 ENOG4105C8Y Acetylornithine aminotransferase NX80_RS09815 ENOG4105CF7 AraC family transcriptional regulator NX80_RS09835 ENOG4105CC0 LysR family Transcriptional regulator NX80_RS09840 ENOG4105F27 Major Facilitator NX80_RS09845 ENOG4108FN7 Aldo keto reductase NX80_RS09875 ENOG4105UGU tonB-dependent Receptor NX80_RS09960 ENOG4105BZU Histidine kinase NX80_RS09965 ENOG4105FE9 pseudouridine synthase NX80_RS09995 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) NX80_RS10000 ENOG4105FQP Beta-lactamase NX80_RS10010 ENOG4105BZU Histidine kinase NX80_RS10015 ENOG4105CK6 Two component transcriptional regulator (Winged helix family NX80_RS10020 ENOG4105ENJ RND efflux system, outer membrane lipoprotein NX80_RS10045 ENOG4105BZ1 (ABC) transporter NX80_RS10095 ENOG4105WG9 Conserved Protein NX80_RS10110 ENOG4107QR8 Thioredoxin NX80_RS10140 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) NX80_RS10160 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) NX80_RS10175 ENOG4105MPN Membrane NX80_RS10185 ENOG4105C03 ribonuclease NX80_RS10190 ENOG4105QD6 exported protein NX80_RS10200 ENOG4105D1U peptidase U62 modulator of DNA gyrase NX80_RS10210 ENOG4105CMS peptidase U62, modulator of DNA gyrase NX80_RS10225 ENOG4105CTB Polyprenyl synthetase NX80_RS10230 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) NX80_RS10235 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) NX80_RS10240 ENOG4105G6Z alkaline phosphatase NX80_RS10245 ENOG4105CK2 sodium dicarboxylate symporter NX80_RS10260 ENOG4105K4H Nlp p60 protein NX80_RS10265 ENOG4105K4H Nlp p60 protein NX80_RS10270 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase NX80_RS10280 ENOG4105MWK D-amino acid dehydrogenase, small subunit NX80_RS10285 ENOG4105DC8 reductase NX80_RS10305 ENOG4105C9K Endothelin-converting enzyme 1 NX80_RS10310 ENOG4105C9K Endothelin-converting enzyme 1 NX80_RS10340 ENOG4105DHP deoxycytidine triphosphate deaminase NX80_RS10375 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) NX80_RS10385 ENOG4108RRZ Transcription elongation factor GreB NX80_RS10465 ENOG4105C8Q Methyl-accepting chemotaxis NX80_RS10490 ENOG4105BZU Histidine kinase NX80_RS10510 ENOG4105KWW Biogenesis protein NX80_RS10515 ENOG4107QX9 Thiol disulfide interChange protein NX80_RS10520 ENOG4105DA4 cytochrome c-type biogenesis protein NX80_RS10525 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) NX80_RS10535 ENOG41060IM Heme exporter protein NX80_RS10550 ENOG4105EMN RNA polymerase sigma factor NX80_RS10605 ENOG4105EGZ biosynthesis protein NX80_RS10630 ENOG4105CPN adenine deaminase NX80_RS10645 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) NX80_RS10660 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) NX80_RS10665 ENOG4105BZ1 (ABC) transporter NX80_RS10670 ENOG41079KZ Major Facilitator Superfamily NX80_RS10680 ENOG4105DEN Luciferase family NX80_RS10710 ENOG4105CJ3 phosphate transporter NX80_RS10715 ENOG4107S90 membrAne NX80_RS10725 ENOG4105C22 threonyL-tRNA synthetase NX80_RS10730 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) NX80_RS10745 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) NX80_RS10760 ENOG4105WJX transcriptional regulator MERR family NX80_RS10780 ENOG4105D3Q Sugar transferase NX80_RS10805 ENOG4107Y2G Glycosyl transferase (Group 1 NX80_RS10815 ENOG4108NQK Catalyzes the transfer of a glucuronic acid (GlcA) residue from UDP-glucuronate to mannose-alpha-1,3-glucose-beta- 1,4-glucose-P-P-polyisoprenyl to form the lipid-linked tetrasaccharide GlcA-Man-Glc(2)-PP-Pol, with a glucuronic acid- beta-mannose linkage. Is involved in the biosynthesis of the exopolysaccharide xanthan, since it catalyzes the fourth glycosylation step in the assembly of the pentasaccharide-P-P- polyisoprenyl repeating unit of xanthan. Is unable to use the trisaccharide acceptor freed from the pyrophosphate lipid moiety. Does not show specificity for the lipidic portion of the acceptor. Shows diminished activity when tested with 6-O-acetyl-mannose- alpha-1,3-glucose-beta-1,4-glucose-P-P-polyisoprenyl, a NX80_RS10840 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) NX80_RS10845 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) NX80_RS10850 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase NX80_RS10870 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) NX80_RS10880 ENOG4105CSU acyl-Coa dehydrogenase NX80_RS10890 ENOG4105QNF Outer membrane lipoprotein NX80_RS10915 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) NX80_RS10920 ENOG4105CQZ Histidine kinase NX80_RS10930 ENOG4105CEN a g-specific adenine glycosylase NX80_RS10940 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) NX80_RS10950 ENOG4105CTU Proline racemase NX80_RS10955 ENOG41080HI glycine oxidase NX80_RS10970 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) NX80_RS10980 ENOG4105DC7 peptidase M24 NX80_RS10995 ENOG4107QTZ amino acid NX80_RS11065 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) NX80_RS11095 ENOG4105F2I Transposase NX80_RS11100 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) NX80_RS11105 ENOG4106H78 methyltransferase NX80_RS11110 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) NX80_RS11125 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding NX80_RS11130 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) NX80_RS11145 ENOG4105E08 Glycoside hydrolase, family 9 NX80_RS11150 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) NX80_RS11190 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) NX80_RS11195 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) NX80_RS11200 ENOG4105VIE preprotein translocase, subunit YajC NX80_RS11205 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) NX80_RS11210 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) NX80_RS11250 ENOG4105DM4 PTS System NX80_RS11255 ENOG4105DE4 1-phosphofructokinase NX80_RS11260 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) NX80_RS11265 ENOG4108M60 Transcriptional regulator NX80_RS11310 ENOG4105BZS acriflavin resistance protein NX80_RS11315 ENOG4105C1P efflux transporter, rnd family, mfp subunit NX80_RS11325 ENOG4105C7I Dehydrogenase NX80_RS11330 ENOG4105C0R drug resistance transporter emrb qaca subfamily NX80_RS11340 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase NX80_RS11345 ENOG4105BZU Histidine kinase NX80_RS11350 ENOG4106BRA Membrane NX80_RS11360 ENOG4105FDK ABC transporter NX80_RS11380 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) NX80_RS11385 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit NX80_RS11445 ENOG4105CJP fad dependent oxidoreductase NX80_RS11450 ENOG4105CFQ glutamine synthetase NX80_RS11465 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) NX80_RS11470 ENOG4107RUE extracellular solute-binding protein family 1 NX80_RS11520 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) NX80_RS11525 ENOG4105F38 ABC transporter, permease NX80_RS11530 ENOG4105D38 putrescine abc transporter NX80_RS11535 ENOG4105C26 Dehydrogenase NX80_RS11550 ENOG4108JU5 Magnesium and cobalt efflux protein NX80_RS11575 ENOG4105C9A Phoh family NX80_RS11595 ENOG4105E4C Lytic transglycosylase catalytic NX80_RS11600 ENOG4108R5F Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) NX80_RS11605 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) NX80_RS11610 ENOG4105EIX cytochrome c1 NX80_RS11615 ENOG4107MKT Stringent starvation protein a NX80_RS11620 ENOG4105KB2 stringent starvation protein b NX80_RS11640 ENOG4108VHC Short-chain dehydrogenase reductase Sdr NX80_RS11645 ENOG4107QRT dEAD DEAH box helicase NX80_RS11650 ENOG4108VX5 3-methyladenine DNA glycosylase NX80_RS11655 ENOG4105C8Q Methyl-accepting chemotaxis NX80_RS11660 ENOG4108V3W Chemotaxis protein, CheW NX80_RS11685 ENOG4105DQE DNA ligase NX80_RS11705 ENOG4105E6M Sulphatase-modifying factor protein NX80_RS11720 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) NX80_RS11725 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) NX80_RS11730 ENOG4105K8N protein family UPF0079, ATPase NX80_RS11735 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase NX80_RS11740 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) NX80_RS11765 ENOG4105CHR reductase NX80_RS11785 ENOG4105CBX hi0933 family NX80_RS11790 ENOG4108VWS Yaeq family NX80_RS11800 ENOG4105VEQ Cold shock protein NX80_RS11805 ENOG4108RXX maleylacetoacetate isomerase NX80_RS11820 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) NX80_RS11825 ENOG4105C1J atp-dependent rna helicase NX80_RS11830 ENOG4105C5H ABC transporter NX80_RS11850 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) NX80_RS11855 ENOG4105ECY inositol monophosphatase NX80_RS11870 ENOG4105BZU Histidine kinase NX80_RS11875 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein NX80_RS11880 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) NX80_RS11895 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) NX80_RS11905 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) NX80_RS11955 ENOG4105CD3 dihydroorotase NX80_RS11975 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) NX80_RS11990 ENOG4105DBV ornithine carbamoyltransferase NX80_RS11995 ENOG4105CDH Citrulline--aspartate ligase NX80_RS12010 ENOG4105CAS nag kinase NX80_RS12020 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase NX80_RS12080 ENOG4108JJ9 ABC, transporter NX80_RS12085 ENOG4108JJ8 (ABC) transporter NX80_RS12105 ENOG4108M1T Cytochrome c-type biogenesis protein NX80_RS12110 ENOG4105KWW Biogenesis protein NX80_RS12120 ENOG4105DA4 cytochrome c-type biogenesis protein NX80_RS12125 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) NX80_RS12135 ENOG41060IM Heme exporter protein NX80_RS12140 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) NX80_RS12145 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) NX80_RS12150 ENOG4105CHM Aminotransferase NX80_RS12175 ENOG4105FE9 pseudouridine synthase NX80_RS12180 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) NX80_RS12185 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) NX80_RS12190 ENOG4105K9H YciI-like protein NX80_RS12210 ENOG4106RHG Yeca family NX80_RS12230 ENOG4108C33 Resolvase NX80_RS12270 ENOG4105CMA conjugation trbi family protein NX80_RS12315 ENOG4108C33 Resolvase NX80_RS12430 ENOG4108C33 Resolvase NX80_RS12450 ENOG4106RHG Yeca family NX80_RS12470 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component NX80_RS12475 ENOG4105DRS transport system, permease NX80_RS12510 ENOG4105DWY Agmatine deiminase NX80_RS12530 ENOG4105CAT Cytidine monophosphate kinase NX80_RS12535 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) NX80_RS12550 ENOG4105CFV Tetratricopeptide repeat protein NX80_RS12565 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase NX80_RS12580 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) NX80_RS12585 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) NX80_RS12605 ENOG4105DND Transcriptional regulator NX80_RS12610 ENOG4105EQ2 LysR family Transcriptional regulator NX80_RS12620 ENOG4105CHR reductase NX80_RS12625 ENOG4105HMI Membrane NX80_RS12630 ENOG4105DUM transcriptional regulator, lysR family NX80_RS12645 ENOG4105WH1 Two component transcriptional regulator luxr family NX80_RS12660 ENOG4105CHJ isochorismatase hydrolase NX80_RS12675 ENOG4107SFI Major Facilitator superfamily NX80_RS12690 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) NX80_RS12695 ENOG4105KST dependent repressor NX80_RS12700 ENOG4108Z6B deaminase NX80_RS12705 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) NX80_RS12720 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) NX80_RS12740 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase NX80_RS12750 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class NX80_RS12775 ENOG4105BZM domain protein NX80_RS12785 ENOG4105BZU Histidine kinase NX80_RS12825 ENOG4105N7H Cytochrome NX80_RS12855 ENOG4108UHU Aldolase NX80_RS12860 ENOG4105C01 Dihydroxy-acid dehydratase NX80_RS12865 ENOG4108Q79 6-phosphogluconolactonase (EC 3.1.1.31) NX80_RS12870 ENOG4105CHC glucokinase (EC 2.7.1.2) NX80_RS12900 ENOG410612Q succinate dehydrogenase (cytochrome b-556 subunit) NX80_RS12925 ENOG410681N tpr repeat protein NX80_RS12935 ENOG4105D60 lipoprotein releasing system transmembrane protein NX80_RS12950 ENOG4108EC8 DNA internalization-related competence protein ComEC NX80_RS12965 ENOG4105BZ1 (ABC) transporter NX80_RS12970 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) NX80_RS12975 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) NX80_RS12990 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) NX80_RS13020 ENOG4107QQG Dehydrogenase NX80_RS13030 ENOG4108V1T peptidylprolyl cis-trans isomerase NX80_RS13060 ENOG4105EI2 Pseudouridine synthase NX80_RS13065 ENOG4108NST exported protein NX80_RS13070 ENOG4105DUN Mediates zinc uptake. May also transport other divalent cations (By similarity) NX80_RS13085 ENOG41090A4 Pterin carbinolamine dehydratase NX80_RS13135 ENOG4105CA0 peroxidase NX80_RS13165 ENOG4107TPY serine threonine protein kinase NX80_RS13170 ENOG4108ZF3 Phosphatase NX80_RS13225 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit NX80_RS13250 ENOG4108WC9 type VI secretion system effector, hcp1 family NX80_RS13270 ENOG4105CMM transposase NX80_RS13335 ENOG4108ZXC Two component transcriptional regulator, luxr family NX80_RS13360 ENOG4108N8X transition metal ion binding NX80_RS13385 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) NX80_RS13395 ENOG41085AN Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) NX80_RS13400 ENOG4105CVM Molybdenum cofactor synthesis domain protein NX80_RS13410 ENOG4105CGK Exodeoxyribonuclease III NX80_RS13450 ENOG4105D06 uba thif-type nad fad binding protein NX80_RS13455 ENOG4105CVM Molybdenum cofactor synthesis domain protein NX80_RS13465 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) NX80_RS13470 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) NX80_RS13480 ENOG4105HSZ Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity) NX80_RS13510 ENOG4105CHU acetyl-coa acetyltransferase NX80_RS13515 ENOG41082MI Protein CrcB homolog NX80_RS13520 ENOG4105D1H recombination factor protein RarA NX80_RS13540 ENOG4105CNU cell division protein FtsK NX80_RS13545 ENOG4105C3M thioredoxin reductase NX80_RS13555 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) NX80_RS13565 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit NX80_RS13580 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) NX80_RS13605 ENOG4105BZU Histidine kinase NX80_RS13610 ENOG4105BZU Histidine kinase NX80_RS13615 ENOG4105BZU Histidine kinase NX80_RS13620 ENOG4105BZU Histidine kinase NX80_RS13655 ENOG4108ZC9 flagellar basal-body rod protein flgc NX80_RS13660 ENOG410822I Flagellar hook capping protein NX80_RS13665 ENOG4105BZE flagellar hook protein, FlgE NX80_RS13670 ENOG4108KPB Flagellar basal-body rod protein FlgF NX80_RS13680 ENOG4105CGA flagellar basal-body rod protein FlgG NX80_RS13685 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) NX80_RS13690 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) NX80_RS13695 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj NX80_RS13715 ENOG4107W9T flagellar hook-associated NX80_RS13740 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) NX80_RS13745 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) NX80_RS13765 ENOG4108P1X synthase NX80_RS13770 ENOG4105H9W Short-chain dehydrogenase reductase Sdr NX80_RS13775 ENOG4105CHR reductase NX80_RS13800 ENOG4107RGC Glycosyl transferase, family 2 NX80_RS13805 ENOG4105VQ0 flagellar hook-basal body complex protein fliE NX80_RS13810 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) NX80_RS13815 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) NX80_RS13825 ENOG4108JIR Flagellum-specific ATP synthase NX80_RS13845 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) NX80_RS13850 ENOG4105DD5 Flagellar motor switch protein NX80_RS13855 ENOG4105K0P flagellar biosynthesis protein NX80_RS13860 ENOG4105CN7 Flagellar biosynthetic protein FliP NX80_RS13870 ENOG4105VS8 Flagellar biosynthetic protein fliq NX80_RS13875 ENOG4105D19 Role in flagellar biosynthesis (By similarity) NX80_RS13880 ENOG4105BZU Histidine kinase NX80_RS13885 ENOG4105BZU Histidine kinase NX80_RS13890 ENOG4105BZU Histidine kinase NX80_RS13895 ENOG4105D00 flagellar biosynthetic protein flhB NX80_RS13900 ENOG4105D7B Flagellar biosynthesis protein flha NX80_RS13910 ENOG4105FZW flagellar biosynthesis regulator FlhF NX80_RS13920 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) NX80_RS13925 ENOG4108VYJ response regulator receiver protein NX80_RS14040 ENOG4105E14 MotA TolQ exbB proton channel NX80_RS14045 ENOG4105ER2 Ompa motb domain protein NX80_RS14050 ENOG4107QJE Chromosome Partitioning Protein NX80_RS14055 ENOG4108V3W Chemotaxis protein, CheW NX80_RS14065 ENOG4108VYJ response regulator receiver protein NX80_RS14070 ENOG4105CBS Chea signal transduction histidine kinase NX80_RS14075 ENOG4105C8Q Methyl-accepting chemotaxis NX80_RS14080 ENOG4105C8Q Methyl-accepting chemotaxis NX80_RS14095 ENOG4105C8Q Methyl-accepting chemotaxis NX80_RS14105 ENOG4105C8Q Methyl-accepting chemotaxis NX80_RS14115 ENOG4105C8Q Methyl-accepting chemotaxis NX80_RS14120 ENOG4105C8Q Methyl-accepting chemotaxis NX80_RS14125 ENOG4105C8Q Methyl-accepting chemotaxis NX80_RS14130 ENOG4105C8Q Methyl-accepting chemotaxis NX80_RS14135 ENOG4105C8Q Methyl-accepting chemotaxis NX80_RS14140 ENOG4105C8Q Methyl-accepting chemotaxis NX80_RS14145 ENOG4105C8Q Methyl-accepting chemotaxis NX80_RS14155 ENOG4108V3W Chemotaxis protein, CheW NX80_RS14165 ENOG4105C8Q Methyl-accepting chemotaxis NX80_RS14170 ENOG4105BZU Histidine kinase NX80_RS14180 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) NX80_RS14185 ENOG4105BZU Histidine kinase NX80_RS14190 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) NX80_RS14195 ENOG4107QIJ Aconitate hydratase 2 NX80_RS14210 ENOG4107QM5 aconitate hydratase NX80_RS14220 ENOG4105CEY Amp-dependent synthetase and ligase NX80_RS14230 ENOG4105F2I Transposase NX80_RS14245 ENOG4105E39 Enoyl-CoA hydratase NX80_RS14255 ENOG4105BZU Histidine kinase NX80_RS14260 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase NX80_RS14265 ENOG4105CRK lysyL-tRNA synthetase NX80_RS14275 ENOG4105DY9 regulatoR NX80_RS14295 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) NX80_RS14305 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) NX80_RS14310 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain NX80_RS14320 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain NX80_RS14325 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) NX80_RS14330 ENOG4108RPX mosc domain containing protein NX80_RS14335 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family NX80_RS14350 ENOG4105CE1 Ferrous iron transport protein b NX80_RS14370 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase NX80_RS14380 ENOG4105FUQ Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) NX80_RS14400 ENOG4105CQB FAD linked oxidase domain protein NX80_RS14405 ENOG4108JQ1 Dehydrogenase NX80_RS14415 ENOG4105CUB amino acid NX80_RS14420 ENOG4105CUB amino acid NX80_RS14425 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) NX80_RS14460 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase NX80_RS14465 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) NX80_RS14470 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase NX80_RS14475 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) NX80_RS14485 ENOG4105CIH Imidazole acetol-phosphate transaminase NX80_RS14490 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) NX80_RS14495 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) NX80_RS14505 ENOG4105CUT histidyl-tRNA synthetase NX80_RS14510 ENOG4105DS0 Transcriptional regulator, Crp Fnr family NX80_RS14520 ENOG4105D98 threonine synthase NX80_RS14630 ENOG4105C26 Dehydrogenase NX80_RS14655 ENOG4108SXK Transporter Drug Metabolite Exporter family NX80_RS14680 ENOG410841Q phosphoesterase PA-phosphatase related protein NX80_RS14685 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) NX80_RS14695 ENOG4108UYB regulatoR NX80_RS14700 ENOG4105KU2 hydrolase family 5 NX80_RS14705 ENOG4105BZU Histidine kinase NX80_RS14750 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) NX80_RS14755 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) NX80_RS14760 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) NX80_RS14765 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase NX80_RS14770 ENOG4105DJ0 Poly(A) Polymerase NX80_RS14815 ENOG4105CMG Carbohydrate kinase NX80_RS14885 ENOG4108RTU Aldolase NX80_RS14900 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 NX80_RS14905 ENOG4108Z4U Ferredoxin NX80_RS14915 ENOG4107TUS Dihydrodipicolinate synthase NX80_RS14930 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen NX80_RS14935 ENOG4108IAB Phoh family NX80_RS14950 ENOG4105DWF phosphomethylpyrimidine kinase NX80_RS14975 ENOG4105CWB LysR family transcriptional Regulator NX80_RS15045 ENOG4107TH8 cina domain protein NX80_RS15050 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) NX80_RS15060 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) NX80_RS15065 ENOG4105EEI dihydropteroate synthase NX80_RS15070 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) NX80_RS15075 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) NX80_RS15080 ENOG4105HBR Rna-binding protein NX80_RS15085 ENOG4108UIV Protein of unknown function (DUF498/DUF598) NX80_RS15090 ENOG4108K5P (LipO)protein NX80_RS15095 ENOG4108UM1 dedA family NX80_RS15100 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) NX80_RS15105 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) NX80_RS15110 ENOG4108DG9 Smr protein MutS2 NX80_RS15135 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) NX80_RS15150 ENOG4105J5G Transferase hexapeptide repeat containing protein NX80_RS15155 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) NX80_RS15165 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) NX80_RS15210 ENOG4106E4H Type IV secretory pathway VirB3 family protein NX80_RS15230 ENOG4105CMA conjugation trbi family protein NX80_RS15295 ENOG4108Z86 Glutamine amidotransferase NX80_RS15310 ENOG4108NIW Leucine export protein LeuE NX80_RS15315 ENOG4105CVG Homoserine O-transsuccinylase NX80_RS15320 ENOG4105CFQ glutamine synthetase NX80_RS15340 ENOG4105HSS phospholipase C NX80_RS15360 ENOG4105ETT transcriptional Regulator, LysR family NX80_RS15375 ENOG4105C5H ABC transporter NX80_RS15380 ENOG4107RNH Outer membrane receptor FepA NX80_RS15395 ENOG4107RNH Outer membrane receptor FepA NX80_RS15400 ENOG4107RNH Outer membrane receptor FepA NX80_RS15415 ENOG4105CKD glutathione-regulated potassium-efflux system protein NX80_RS15425 ENOG4105GAV receptor NX80_RS15440 ENOG4105C6X Major Facilitator NX80_RS15450 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) NX80_RS15485 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) NX80_RS15505 ENOG4105F2I Transposase NX80_RS15550 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit NX80_RS15555 ENOG4105E2Y ABC, transporter NX80_RS15560 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component NX80_RS15565 ENOG4105GVF (ABC) transporter NX80_RS15570 ENOG4105CPC Aldo Keto reductase NX80_RS15580 ENOG4107ZSV Receptor NX80_RS15585 ENOG41082IR Excinuclease ABC C subunit domain protein NX80_RS15625 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) NX80_RS15635 ENOG4108K4C ec 3.1.3.12 NX80_RS15645 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase NX80_RS15650 ENOG4105DZG Dehydrogenase NX80_RS15655 ENOG4105C8Q Methyl-accepting chemotaxis NX80_RS15660 ENOG4105KIR Thiol-disulfide oxidoreductase dcc NX80_RS15675 ENOG4105C34 Pseudouridine synthase NX80_RS15680 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane NX80_RS15730 ENOG4108ZAF Molybdopterin NX80_RS15735 ENOG4105M00 molybdopterin converting factor, subunit 1 NX80_RS15750 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) NX80_RS15755 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) NX80_RS15760 ENOG4108W7E Catalyzes the ATP-dependent phosphorylation of the 3- deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position (By similarity) NX80_RS15765 ENOG4105DKP glycosyl transferase, family 9 NX80_RS15780 ENOG4108ZF3 Phosphatase NX80_RS15790 ENOG4107RZZ dna polymerase iii epsilon subunit NX80_RS15805 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) NX80_RS15810 ENOG41068JE domain protein NX80_RS15815 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) NX80_RS15845 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) NX80_RS15855 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation NX80_RS15900 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) NX80_RS15915 ENOG4105VW4 glutaredoxin 3 NX80_RS15920 ENOG4105ERG peptidase m48, ste24p NX80_RS15925 ENOG4105CK6 Two component transcriptional regulator (Winged helix family NX80_RS15930 ENOG4105BZU Histidine kinase NX80_RS15935 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) NX80_RS15940 ENOG4105C9X ppx gppa phosphatase NX80_RS15945 ENOG4105BZF Glycosyl transferase (Group 1 NX80_RS15950 ENOG4105EYK Phosphatidylglycerophosphatase B NX80_RS15955 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) NX80_RS15965 ENOG4108YP4 Metalloprotease, specifically cleaves on the N-terminal side of aspartyl, glutamyl and cysteic acid residues (By similarity) NX80_RS15970 ENOG4105ED9 Protein of unknown function (DUF455) NX80_RS15975 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase NX80_RS15990 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase NX80_RS16000 ENOG4105CVJ phosphoglycerate mutase NX80_RS16010 ENOG4105HSS phospholipase C NX80_RS16030 ENOG4108IJ6 ABC transporter NX80_RS16040 ENOG4108I5D sulfate abc transporter NX80_RS16045 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein NX80_RS16050 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) NX80_RS16060 ENOG4108R99 pseudouridine synthase NX80_RS16070 ENOG4105F37 PsaA and PsaB bind P700, the primary electron donor of photosystem I (PSI), as well as the electron acceptors A0, A1 and FX. PSI is a plastocyanin cytochrome c6-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn. Oxidized P700 is reduced on the lumenal side of the thylakoid membrane by plastocyanin or cytochrome c6 NX80_RS16075 ENOG4105CIS alcohol dehydrogenase NX80_RS16080 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase NX80_RS16100 ENOG4108K3A Glutathione S-transferase NX80_RS16105 ENOG4105D9Z Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) NX80_RS16110 ENOG4107XH4 PPIases accelerate the folding of proteins (By similarity) NX80_RS16115 ENOG4105CI3 gtp-binding protein typa NX80_RS16140 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase NX80_RS16155 ENOG41080I0 Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) NX80_RS16185 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) NX80_RS16190 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) NX80_RS16230 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) NX80_RS16270 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity NX80_RS16280 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) NX80_RS16290 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) NX80_RS16310 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) NX80_RS16315 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) NX80_RS16320 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) NX80_RS16335 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) NX80_RS16345 ENOG4108VZM 50s ribosomal protein L10 NX80_RS16350 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) NX80_RS16355 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) NX80_RS16360 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) NX80_RS16365 ENOG4105PM1 preprotein translocase subunit SecE NX80_RS16375 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) NX80_RS16395 ENOG4105C3G gtp-binding protein NX80_RS16400 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) NX80_RS16405 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) NX80_RS16410 ENOG4105C5T Phosphoribosyl pyrophosphate synthase NX80_RS16420 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) NX80_RS16425 ENOG4105QVB outer membrane lipoprotein LolB NX80_RS16430 ENOG4105DJQ tetratricopeptide tpr_2 repeat protein NX80_RS16450 ENOG4108RIR Molybdenum cofactor biosynthesis protein NX80_RS16455 ENOG4105CSR polyphosphate kinase 2 NX80_RS16470 ENOG4107QX9 Thiol disulfide interChange protein NX80_RS16475 ENOG4107S2Z UPF0761 membrane protein NX80_RS16480 ENOG4105CS1 NAD(P)H quinone oxidoreductase NX80_RS16500 ENOG4108Z66 YbaK ebsC protein NX80_RS16505 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin NX80_RS16510 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin NX80_RS16515 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin NX80_RS16520 ENOG4105CM2 brancheD-chain amino acid aminotransferase NX80_RS16540 ENOG4105W8H transhydrogenase (subunit alpha NX80_RS16565 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) NX80_RS16585 ENOG4105C2M dna polymerase I NX80_RS16630 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) NX80_RS16645 ENOG4105C5Q Transcriptional regulator NX80_RS16650 ENOG4105NXH GreA GreB family elongation factor NX80_RS16655 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) NX80_RS16675 ENOG4105WH1 Two component transcriptional regulator luxr family NX80_RS16680 ENOG4105BZU Histidine kinase NX80_RS16700 ENOG4105CX6 glutaminyL-tRNA synthetase NX80_RS16710 ENOG4105DXC membrane NX80_RS16755 ENOG4108D7R p-hydroxycinnamoyl CoA hydratase lyase NX80_RS16765 ENOG4105CEY Amp-dependent synthetase and ligase NX80_RS16770 ENOG4105DDW LysR family Transcriptional regulator NX80_RS16800 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family NX80_RS16805 ENOG4105D0A hydroxylase NX80_RS16820 ENOG4108WBT adenosyltransferase NX80_RS16830 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) NX80_RS16840 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) NX80_RS16850 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) NX80_RS16855 ENOG4105NWN ApaG protein NX80_RS16860 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) NX80_RS16875 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) NX80_RS16895 ENOG41080IJ Diacylglycerol kinase NX80_RS16910 ENOG4105DHQ Histidine kinase NX80_RS16925 ENOG4108I0Y (ABC) transporter NX80_RS16935 ENOG4105E2B Taurine dioxygenase NX80_RS16950 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component NX80_RS16970 ENOG4105D05 Receptor NX80_RS16985 ENOG4105CPC Aldo Keto reductase NX80_RS16990 ENOG4105D9N nucleoside NX80_RS17005 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) NX80_RS17010 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) NX80_RS17030 ENOG4105D6F Phosphatase NX80_RS17055 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) NX80_RS17070 ENOG4105DXX methyltransferase NX80_RS17130 ENOG4105SYT Methylenetetrahydrofolate reductase NX80_RS17140 ENOG4105M6F mutator MutT protein NX80_RS17145 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving NX80_RS17150 ENOG4105DR5 peptidase NX80_RS17160 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) NX80_RS17165 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) NX80_RS17170 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) NX80_RS17175 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) NX80_RS17180 ENOG4105CPF Cell wall formation (By similarity) NX80_RS17185 ENOG4105DFU Cell wall formation (By similarity) NX80_RS17190 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) NX80_RS17200 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) NX80_RS17205 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) NX80_RS17215 ENOG4105CJN penicillin-binding protein NX80_RS17220 ENOG4106932 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) NX80_RS17225 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) NX80_RS17275 ENOG4105S2T inner membrane protein YbcI NX80_RS17280 ENOG4105CQB FAD linked oxidase domain protein NX80_RS17285 ENOG4105EEX Two component transcriptional regulator (Winged helix family NX80_RS17290 ENOG4105C08 Histidine kinase NX80_RS17300 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) NX80_RS17305 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) NX80_RS17350 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) NX80_RS17360 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) NX80_RS17365 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) NX80_RS17380 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) NX80_RS17390 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) NX80_RS17395 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) NX80_RS17420 ENOG4105C5H ABC transporter NX80_RS17425 ENOG4108RBJ Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) NX80_RS17455 ENOG4107RH7 Nicotinate phosphoribosyltransferase NX80_RS17505 ENOG4106S9K Transcriptional regulator NX80_RS17515 ENOG4105GVR general secretion pathway protein D NX80_RS17525 ENOG410678M general secretion pathway protein M NX80_RS17530 ENOG41090VX general secretion pathway protein L NX80_RS17535 ENOG4105UV2 general secretion pathway protein K NX80_RS17540 ENOG41069G9 General secretion pathway protein J NX80_RS17550 ENOG4105WMT general secretion pathway protein h NX80_RS17560 ENOG4105D7Q type ii secretion system NX80_RS17570 ENOG4107QHF type ii secretion system protein e NX80_RS17575 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin NX80_RS17585 ENOG4105EUR Domain-Containing protein NX80_RS17595 ENOG4108ETH Formylglycinamide ribotide synthetase NX80_RS17605 ENOG4105T95 Thiol disulfide interChange protein NX80_RS17610 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) NX80_RS17620 ENOG4108K5H permease YjgP YjgQ family protein NX80_RS17630 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) NX80_RS17645 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) NX80_RS17680 ENOG4105F2I Transposase NX80_RS17690 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) NX80_RS17715 ENOG4107BJW polysaccharide deacetylase NX80_RS17720 ENOG4105CND Glycosyl transferase, family 2 NX80_RS17735 ENOG4105CE4 GlcNAc 6-P deacetylase NX80_RS17740 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) NX80_RS17745 ENOG4105ETE Transcriptional regulator (LacI family NX80_RS17770 ENOG4105CNT hydrolase family 2 NX80_RS17800 ENOG4105H9W Short-chain dehydrogenase reductase Sdr NX80_RS17810 ENOG4105BZU Histidine kinase NX80_RS17820 ENOG4105BZU Histidine kinase NX80_RS17825 ENOG4105W4M Transport-associated protein NX80_RS17830 ENOG4105D9R oxidoreductase NX80_RS17835 ENOG4108J5G 6-phosphogluconate dehydrogenase NX80_RS17880 ENOG4105CN1 protease NX80_RS17885 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) NX80_RS17890 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) NX80_RS17905 ENOG4105DZ1 carboxypeptidase NX80_RS17910 ENOG4105K6T rare lipoprotein A NX80_RS17915 ENOG4105CVE Lytic murein transglycosylase NX80_RS17965 ENOG4105CNI cell division protein FtsW NX80_RS17980 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) NX80_RS17990 ENOG4107T4Z adenosine kinase NX80_RS18010 ENOG4105DTI Phosphonopyruvate decarboxylase NX80_RS18025 ENOG4105CAQ asparagine synthetase NX80_RS18035 ENOG4105HF0 Membrane NX80_RS18070 ENOG4105CD8 aminopeptidase N NX80_RS18075 ENOG4105BZU Histidine kinase NX80_RS18085 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) NX80_RS18110 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) NX80_RS18115 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) NX80_RS18125 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) NX80_RS18135 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) NX80_RS18145 ENOG4105WD1 Membrane NX80_RS18200 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) NX80_RS18205 ENOG4108NEV two component transcriptional regulator, LytTR family NX80_RS18210 ENOG4108HRK Histidine kinase NX80_RS18220 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) NX80_RS18245 ENOG4105CHH sulfate transporter NX80_RS18250 ENOG4106R7G Glycoside hydrolase family 5 NX80_RS18255 ENOG4105C8Q Methyl-accepting chemotaxis NX80_RS18265 ENOG4105BZU Histidine kinase NX80_RS18295 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) NX80_RS18345 ENOG4108YQE rare lipoprotein a NX80_RS18360 ENOG4105F87 Dehydratase NX80_RS18365 ENOG4105DFI Membrane NX80_RS18390 ENOG4105BZU Histidine kinase NX80_RS18395 ENOG4107QS8 (LipO)protein NX80_RS18435 ENOG4105CHF Glutathione S-transferase NX80_RS18440 ENOG4105PDP Short chain dehydrogenase NX80_RS18500 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) NX80_RS18510 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) NX80_RS18550 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) NX80_RS18555 ENOG4105DRR Transcriptional regulator, GntR family NX80_RS18575 ENOG41065ZS Transfers 2'-(5-triphosphoribosyl)-3'-dephosphocoenzyme- A to the apo- acyl-carrier-protein of the malonate decarboxylase to yield holo- acyl-carrier-protein (By similarity) NX80_RS18590 ENOG4105WSE Subunit of malonate decarboxylase, it is an acyl carrier protein to which acetyl and malonyl thioester residues are bound via a 2'-(5''-phosphoribosyl)-3'-dephospho-CoA prosthetic group and turn over during the catalytic mechanism (By similarity) NX80_RS18630 ENOG4108YYC ycei family NX80_RS18635 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) NX80_RS18675 ENOG4105J1P transposase, IS3 IS911 family protein NX80_RS18685 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) NX80_RS18715 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) NX80_RS18720 ENOG4105D05 Receptor NX80_RS18755 ENOG4108K8S endonuclease I NX80_RS18765 ENOG4105VF7 tolerance protein NX80_RS18770 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) NX80_RS18780 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein NX80_RS18790 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase NX80_RS18840 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) NX80_RS18860 ENOG4108UMZ Cdp-alcohol phosphatidyltransferase NX80_RS18865 ENOG4105DC1 bifunctional purine biosynthesis protein purh NX80_RS18870 ENOG4107WZZ SMC domain protein NX80_RS18880 ENOG4105C12 Phosphoribosylglycinamide synthetase NX80_RS18885 ENOG4105EM2 membrane NX80_RS18900 ENOG4108J8Q Catalyzes the facilitated diffusion of 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) into the cell (By similarity) NX80_RS18920 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) NX80_RS18935 ENOG4108YX9 iron--sulfur cluster insertion protein erpA NX80_RS18955 ENOG4105CK6 Two component transcriptional regulator (Winged helix family NX80_RS18960 ENOG4105BZU Histidine kinase NX80_RS18965 ENOG4108UQY Iron-storage protein NX80_RS19015 ENOG4107RYR Transcriptional regulator, Crp Fnr family NX80_RS19030 ENOG4108I0Q anthranilate phosphoribosyltransferase NX80_RS19040 ENOG4105DDQ anthranilate synthase NX80_RS19055 ENOG4105CRQ synthase (Component I) NX80_RS19060 ENOG4107TE5 Lipid kinase NX80_RS19065 ENOG4105KD7 acetyltransferase NX80_RS19070 ENOG4105DJV ribulose-phosphate 3-epimerase NX80_RS19080 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) NX80_RS19085 ENOG4105C8V SAICAR synthetase NX80_RS19125 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) NX80_RS19130 ENOG4105DJY efflux transporter, rnd family, mfp subunit NX80_RS19135 ENOG4105C19 ABC transporter NX80_RS19140 ENOG4107RBB ABC transporter, permease NX80_RS19145 ENOG4107RBB ABC transporter, permease NX80_RS19150 ENOG4105F2I Transposase NX80_RS19165 ENOG4105BZU Histidine kinase NX80_RS19205 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) NX80_RS19210 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) NX80_RS19215 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) NX80_RS19225 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) NX80_RS19230 ENOG4107RAZ it plays a direct role in the translocation of protons across the membrane (By similarity) NX80_RS19250 ENOG4107QN2 dihydrolipoyl dehydrogenase NX80_RS19260 ENOG4107QSN dihydrolipoamide acetyltransferase NX80_RS19300 ENOG4105D01 (LipO)protein NX80_RS19305 ENOG4108UMI ABC transporter, permease NX80_RS19310 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) NX80_RS19315 ENOG4108EHX EamA-like transporter family NX80_RS19320 ENOG4108VPT UPF0234 protein NX80_RS19330 ENOG4105BZU Histidine kinase NX80_RS19345 ENOG4107EXU Short-chain dehydrogenase reductase Sdr NX80_RS19350 ENOG4107YBY Hydrolase NX80_RS19355 ENOG4105I08 Pseudouridine synthase NX80_RS19360 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) NX80_RS19390 ENOG4105BZU Histidine kinase NX80_RS19410 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) NX80_RS19415 ENOG4105MWK D-amino acid dehydrogenase, small subunit NX80_RS19420 ENOG4105EW9 transcriptional regulator AsnC family NX80_RS19440 ENOG4107RD7 Flagellar Motor Protein, MotA NX80_RS19445 ENOG4105ER2 Ompa motb domain protein NX80_RS19460 ENOG4105XJC Two component transcriptional regulator (Winged helix family NX80_RS19475 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin NX80_RS19500 ENOG4105E3A (ABC) transporter NX80_RS19505 ENOG4105DA5 (ABC) transporter NX80_RS19510 ENOG4105EEQ Na H antiporter NX80_RS19525 ENOG4108UN4 phage SPO1 DNA polymerase-related protein NX80_RS19540 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b NX80_RS19550 ENOG4105CBN LysR family transcriptional regulator NX80_RS19560 ENOG4105CPC Aldo Keto reductase NX80_RS19570 ENOG4105C9K Endothelin-converting enzyme 1 NX80_RS19585 ENOG4107QTZ amino acid NX80_RS19595 ENOG4108VAC response regulator NX80_RS19600 ENOG4105C2F Histidine kinase NX80_RS19625 ENOG4108Z9Z response to DNA damage stimulus NX80_RS19630 ENOG4105WEF catalase NX80_RS19650 ENOG4105BZU Histidine kinase NX80_RS19665 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family NX80_RS19680 ENOG4105C4M (Ubiquinol oxidase) subunit I NX80_RS19685 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii NX80_RS19700 ENOG4105CYX Short-chain dehydrogenase reductase Sdr NX80_RS19705 ENOG4105CMR udp-glucose 4-epimerase NX80_RS19710 ENOG4105CMR udp-glucose 4-epimerase NX80_RS19730 ENOG4105BZ1 (ABC) transporter NX80_RS19745 ENOG4105E2A Dehydrogenase NX80_RS19800 ENOG4105DA5 (ABC) transporter NX80_RS19830 ENOG4105CMQ Chloride channel NX80_RS19960 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) NX80_RS19965 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) NX80_RS19970 ENOG4105D1S lipid A biosynthesis NX80_RS19975 ENOG4108Z7F N-acetyltransferase NX80_RS20015 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B NX80_RS20020 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) NX80_RS20025 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) NX80_RS20030 ENOG4108WZM domain protein NX80_RS20035 ENOG4105C79 DNA protecting protein DprA NX80_RS20055 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) NX80_RS20075 ENOG4107ZQV short-chain dehydrogenase reductase NX80_RS20085 ENOG4105D07 Signal peptide peptidase, SppA NX80_RS20090 ENOG4107QI1 Mate efflux family protein NX80_RS20110 ENOG4105C25 Primosomal protein n' NX80_RS20115 ENOG4108TGY Glutathione S-transferase NX80_RS20135 ENOG4105EN6 Membrane NX80_RS20140 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) NX80_RS20150 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase NX80_RS20155 ENOG4105CRP Part of the ABC transporter FtsEX involved in NX80_RS20160 ENOG4105CAK Cell division ATP-binding protein ftsE NX80_RS20175 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) NX80_RS20185 ENOG4105VS7 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) NX80_RS20190 ENOG4105ETT transcriptional Regulator, LysR family NX80_RS20200 ENOG4105E9K Isocitrate dehydrogenase NX80_RS20215 ENOG4105FB9 CRISPR-associated protein NX80_RS20235 ENOG4105DYN CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) NX80_RS20240 ENOG4105KCF CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity) NX80_RS20260 ENOG4109066 lysm domain bon superfamily protein NX80_RS20265 ENOG4107R1K Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) NX80_RS20280 ENOG4105BZS acriflavin resistance protein NX80_RS20300 ENOG4105E32 cytoplasmic protein NX80_RS20340 ENOG4108UQS dipeptidase NX80_RS20345 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase NX80_RS20355 ENOG4105DTQ mandelate racemase muconate lactonizing NX80_RS20365 ENOG4105D5Q Arginine ornithine antiporter NX80_RS20380 ENOG4108Z12 YiaAB two helix domain-containing protein NX80_RS20390 ENOG4107QK4 glycoside hydrolase, family 3 domain protein NX80_RS20395 ENOG4107ZVW dihydroneopterin aldolase NX80_RS20410 ENOG4105KTH gatB Yqey NX80_RS20415 ENOG4107S2Z UPF0761 membrane protein NX80_RS20420 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) NX80_RS20425 ENOG4105DHU Bile acid NX80_RS20460 ENOG4107QS1 Cytochrome C Oxidase, Subunit III NX80_RS20465 ENOG4105FT1 Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I (By similarity) NX80_RS20480 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) NX80_RS20490 ENOG4105C26 Dehydrogenase NX80_RS20505 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) NX80_RS20540 ENOG4105DR5 peptidase NX80_RS20555 ENOG4105EYM Major Facilitator superfamily NX80_RS20560 ENOG4105CGK Exodeoxyribonuclease III NX80_RS20575 ENOG4107QJE Chromosome Partitioning Protein NX80_RS20580 ENOG4105FA0 parb-like partition protein NX80_RS20595 ENOG4105CKK Glycosyl transferase, family 2 NX80_RS20610 ENOG4107QKV phosphomannomutase NX80_RS20620 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase NX80_RS20630 ENOG4105C75 arginyL-tRNA synthetase NX80_RS20645 ENOG4105EMU Dehydrogenase NX80_RS20665 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) NX80_RS20670 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) NX80_RS20700 ENOG4105CPE K01197 hyaluronoglucosaminidase EC 3.2.1.35 NX80_RS20705 ENOG4108YZA Nitrogen regulatory protein pii NX80_RS20710 ENOG4105W0Z cytoplasmic protein NX80_RS20715 ENOG4105C0P Mg chelatase subunit ChlI NX80_RS20730 ENOG41066DG (EAL) domain protein NX80_RS20745 ENOG4105EJ2 Transcriptional regulator NX80_RS20760 ENOG4105E0Y RtcB Protein NX80_RS20795 ENOG4105ECP epimerase NX80_RS20805 ENOG4105C0H protease NX80_RS20825 ENOG4105C02 permease NX80_RS20830 ENOG4107URF beta-phospho-glucomutase NX80_RS20835 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) NX80_RS20845 ENOG4105EMN RNA polymerase sigma factor NX80_RS20850 ENOG4107VGR Catalase NX80_RS20865 ENOG4108S01 response regulator NX80_RS20870 ENOG4108ZGX Histidine kinase NX80_RS20875 ENOG4105ENT Efflux transporter rnd family, mfp subunit NX80_RS20880 ENOG4105C19 ABC transporter NX80_RS20905 ENOG4105FDR Membrane NX80_RS20930 ENOG4108NNI Beta-lactamase domain-containing protein NX80_RS20935 ENOG4105C31 Tryptophanyl-tRNA synthetase NX80_RS20940 ENOG4105VDW Csbd family NX80_RS21020 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase NX80_RS21035 ENOG4105EXZ Involved in the regulation of ptsG expression by binding and inactivating Mlc (By similarity) NX80_RS21050 ENOG4105EB3 Histidine kinase NX80_RS21055 ENOG4105XJC Two component transcriptional regulator (Winged helix family NX80_RS21065 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) NX80_RS21085 ENOG4105CH6 catalase NX80_RS21100 ENOG4105DVT helicase NX80_RS21115 ENOG4105E2X shikimate dehydrogenase NX80_RS21155 ENOG4105D52 delta-aminolevulinic acid dehydratase NX80_RS21190 ENOG4105CYM Glutathione S-transferase NX80_RS21210 ENOG4105QV4 Tryptophan halogenase NX80_RS21225 ENOG4108IUW ABC transporter NX80_RS21240 ENOG4105VZ8 Transcriptional regulator NX80_RS21255 ENOG4105PGM cation diffusion facilitator family transporter NX80_RS21260 ENOG4107SC0 ferredoxin--NADP reductase NX80_RS21265 ENOG4105DA5 (ABC) transporter NX80_RS21270 ENOG4105E3A (ABC) transporter NX80_RS21280 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) NX80_RS21310 ENOG4105K63 Thioredoxin NX80_RS21325 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) NX80_RS21335 ENOG4107QYD Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) NX80_RS21350 ENOG4105CD5 CoA-binding domain protein NX80_RS21360 ENOG4105CJW magnesium transporter NX80_RS21380 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase NX80_RS21385 ENOG4105BZP glycoside hydrolase 15-related NX80_RS21405 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) NX80_RS21415 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) NX80_RS21455 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) NX80_RS21460 ENOG4105E9Q Acyl-transferase NX80_RS21470 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) NX80_RS21525 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) NX80_RS21530 ENOG4108JPW Aminotransferase NX80_RS21565 ENOG4105XJC Two component transcriptional regulator (Winged helix family NX80_RS21570 ENOG4105C2M dna polymerase I NX80_RS21615 ENOG4105C4R Atp-dependent dna helicase NX80_RS21635 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) NX80_RS21645 ENOG4105KHM amidohydrolase 2 NX80_RS21670 ENOG4105ENT Efflux transporter rnd family, mfp subunit NX80_RS21695 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) NX80_RS21725 ENOG4105CGK Exodeoxyribonuclease III NX80_RS21730 ENOG41061DF Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P (By similarity) NX80_RS21740 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) NX80_RS21750 ENOG4107QN1 sodium solute NX80_RS21755 ENOG41062QD Membrane NX80_RS21815 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr NX80_RS21820 ENOG4105ERH Fumarylacetoacetate hydrolase NX80_RS21825 ENOG4105DIA mandelate racemase muconate lactonizing NX80_RS21830 ENOG4105QJH Domain of unknown function (DUF718) NX80_RS21835 ENOG4105EDR glucose galactose transporter NX80_RS21840 ENOG4108K2P TRANSCRIPTIONal NX80_RS21855 ENOG4105BZU Histidine kinase NX80_RS21865 ENOG4105E2V Glycosyltransferase 36 NX80_RS21870 ENOG4105CT4 transporter NX80_RS21875 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family NX80_RS21915 ENOG4105MA0 exported protein NX80_RS21920 ENOG4105CFU surface antigen NX80_RS21955 ENOG4105D05 Receptor NX80_RS21960 ENOG4107RDJ Sulfotransferase NX80_RS21970 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit NX80_RS21975 ENOG4107QHF type ii secretion system protein e NX80_RS21990 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) NX80_RS22000 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) NX80_RS22005 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) NX80_RS22020 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) NX80_RS22040 ENOG4105DH7 May be involved in recombination (By similarity) NX80_RS22045 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) NX80_RS22060 ENOG4105ETE Transcriptional regulator (LacI family NX80_RS22065 ENOG4105D0H Alpha-glucuronidase (EC 3.2.1.139) NX80_RS22075 ENOG4105CXK mandelate racemase muconate lactonizing NX80_RS22090 ENOG4105DEI Mannitol dehydrogenase NX80_RS22160 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) NX80_RS22195 ENOG4105D2H Uronic isomerase NX80_RS22220 ENOG4105CT4 transporter NX80_RS22225 ENOG4105DT9 hydrolase family 43 NX80_RS22260 ENOG4105E55 glycerol-3-phosphate acyltransferase NX80_RS22270 ENOG4105ETE Transcriptional regulator (LacI family NX80_RS22285 ENOG4105QV4 Tryptophan halogenase NX80_RS22290 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) NX80_RS22295 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family NX80_RS22300 ENOG4108YXG UPF0502 protein NX80_RS22315 ENOG4105C4R Atp-dependent dna helicase NX80_RS22320 ENOG4107104 thymidine kinase NX80_RS22330 ENOG4105DJ9 glucan biosynthesis protein NX80_RS22395 ENOG4105DSB aldose 1-epimerase NX80_RS22405 ENOG4105K5B UPF0225 protein NX80_RS22410 ENOG4105EJ9 Membrane NX80_RS22430 ENOG4105EUJ GTP cyclohydrolase i NX80_RS22440 ENOG4105ZQC membrane protein AaeX NX80_RS22445 ENOG4105Y49 secretion protein, HlyD family NX80_RS22455 ENOG4105DR8 Membrane NX80_RS22460 ENOG4105CSH Transporter NX80_RS22470 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) NX80_RS22575 ENOG4105VDM plasmid maintenance system antidote protein, xre family NX80_RS22590 ENOG4107QKA exodeoxyribonuclease V beta NX80_RS22595 ENOG4105DSY exodeoxyribonuclease V, gamma NX80_RS22630 ENOG4105DHJ ABC, transporter NX80_RS22635 ENOG4105CY3 ABC transporter, permease NX80_RS22640 ENOG4107PE3 Mammalian cell entry related domain protein NX80_RS22655 ENOG410903C (LipO)protein NX80_RS22670 ENOG4108V06 Glutathione peroxidase NX80_RS22680 ENOG4107QSV RmuC domain protein NX80_RS22685 ENOG4105CIS alcohol dehydrogenase NX80_RS22720 ENOG4105CUB amino acid NX80_RS22735 ENOG4105NRM Membrane NX80_RS22745 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR NX80_RS22750 ENOG4105BZW Glycerate kinase NX80_RS22755 ENOG4105CSP Major Facilitator Superfamily NX80_RS22775 ENOG4105DR4 Methyltransferase NX80_RS22785 ENOG4105DU1 integral membrane protein, terc NX80_RS22795 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase NX80_RS22820 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins NX80_RS22845 ENOG4105C26 Dehydrogenase NX80_RS22990 ENOG4108C33 Resolvase