locus-tag	class	description
NX80_RS00025	COG0187	DNA topoisomerase II activity
NX80_RS00035	COG0501	Belongs to the peptidase M48B family
NX80_RS00065	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
NX80_RS00120	COG0793	Belongs to the peptidase S41A family
NX80_RS00125	COG4942	peptidase
NX80_RS00135	COG2234	aminopeptidase activity
NX80_RS00145	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
NX80_RS00155	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
NX80_RS00165	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
NX80_RS00175	COG1064	alcohol dehydrogenase
NX80_RS00190	COG0493	'glutamate synthase
NX80_RS00195	COG0067	glutamate synthase
NX80_RS00195	COG0069	glutamate synthase activity
NX80_RS00195	COG0070	glutamate synthase
NX80_RS00280	COG1111	helicase
NX80_RS00280	COG1205	dead DEAH box helicase
NX80_RS00285	COG1272	protein, Hemolysin III
NX80_RS00345	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NX80_RS00395	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
NX80_RS00410	COG3039	Transposase
NX80_RS00425	COG4772	TonB-dependent receptor
NX80_RS00450	COG1304	FMN binding
NX80_RS00570	COG1522	sequence-specific DNA binding
NX80_RS00575	COG3186	Phenylalanine-4-hydroxylase
NX80_RS00585	COG2755	lipolytic protein G-D-S-L family
NX80_RS00595	COG1028	Short-chain dehydrogenase reductase Sdr
NX80_RS00600	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
NX80_RS00605	COG1609	Transcriptional regulator
NX80_RS00610	COG3507	Belongs to the glycosyl hydrolase 43 family
NX80_RS00625	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
NX80_RS00635	COG2755	lipolytic protein G-D-S-L family
NX80_RS00635	COG0657	acetylesterase activity
NX80_RS00660	COG0366	Alpha amylase catalytic
NX80_RS00665	COG0366	Alpha amylase catalytic
NX80_RS00675	COG2831	hemolysin activation secretion protein
NX80_RS00680	COG3210	domain, Protein
NX80_RS00695	COG3210	domain, Protein
NX80_RS00730	COG2951	lytic endotransglycosylase activity
NX80_RS00735	COG1752	Esterase of the alpha-beta hydrolase superfamily
NX80_RS00740	COG1473	amidohydrolase
NX80_RS00750	COG1119	ATPase activity
NX80_RS00765	COG1125	glycine betaine transport
NX80_RS00765	COG0517	IMP dehydrogenase activity
NX80_RS00780	COG1262	PFAM Formylglycine-generating sulfatase enzyme
NX80_RS00815	COG0489	protein tyrosine kinase activity
NX80_RS00820	COG2062	phosphohistidine phosphatase, SixA
NX80_RS00830	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NX80_RS00880	COG1968	undecaprenyl-diphosphatase activity
NX80_RS00885	COG0174	glutamine synthetase
NX80_RS00890	COG0347	Belongs to the P(II) protein family
NX80_RS00895	COG0004	ammonium transporteR
NX80_RS00900	COG3852	Histidine kinase
NX80_RS00905	COG2204	response regulator
NX80_RS00910	COG2032	superoxide dismutase activity
NX80_RS00915	COG2032	superoxide dismutase activity
NX80_RS00925	COG0346	lactoylglutathione lyase activity
NX80_RS00935	COG0183	Belongs to the thiolase family
NX80_RS00975	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NX80_RS00980	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
NX80_RS00985	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
NX80_RS00995	COG0028	Belongs to the TPP enzyme family
NX80_RS01000	COG2205	protein histidine kinase activity
NX80_RS01025	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
NX80_RS01040	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NX80_RS01045	COG3177	Filamentation induced by cAMP protein fic
NX80_RS01050	COG0596	Alpha beta hydrolase
NX80_RS01055	COG0727	PFAM Uncharacterised protein family (UPF0153)
NX80_RS01060	COG0318	PFAM AMP-dependent synthetase and ligase
NX80_RS01065	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NX80_RS01085	COG1181	Belongs to the D-alanine--D-alanine ligase family
NX80_RS01095	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
NX80_RS01100	COG4122	O-methyltransferase activity
NX80_RS01105	COG0564	pseudouridine synthase activity
NX80_RS01125	COG1446	asparaginase
NX80_RS01130	COG0339	signal peptide processing
NX80_RS01160	COG0475	glutathione-regulated potassium exporter activity
NX80_RS01165	COG0583	DNA-binding transcription factor activity
NX80_RS01170	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
NX80_RS01175	COG2224	Isocitrate lyase
NX80_RS01180	COG3039	Transposase
NX80_RS01185	COG3706	GGDEF domain
NX80_RS01210	COG4770	biotin carboxylase activity
NX80_RS01215	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NX80_RS01220	COG1960	acyl-CoA dehydrogenase activity
NX80_RS01275	COG0523	cobalamin synthesis protein
NX80_RS01295	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
NX80_RS01305	COG1846	Transcriptional regulator
NX80_RS01310	COG1764	response to oxidative stress
NX80_RS01335	COG2130	NADP-dependent
NX80_RS01350	COG1187	pseudouridine synthase activity
NX80_RS01360	COG1643	Atp-dependent helicase
NX80_RS01365	COG4807	Protein conserved in bacteria
NX80_RS01370	COG2351	hydroxyisourate hydrolase activity
NX80_RS01375	COG2072	flavoprotein involved in K transport
NX80_RS01395	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
NX80_RS01445	COG2252	PERMEase
NX80_RS01465	COG0084	hydrolase, TatD family'
NX80_RS01500	COG0583	DNA-binding transcription factor activity
NX80_RS01505	COG2814	Major facilitator Superfamily
NX80_RS01510	COG4221	oxidoreductase activity
NX80_RS01520	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
NX80_RS01525	COG1902	pentaerythritol trinitrate reductase activity
NX80_RS01550	COG0745	RESPONSE REGULATOR receiver
NX80_RS01570	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
NX80_RS01575	COG0583	DNA-binding transcription factor activity
NX80_RS01610	COG0702	epimerase
NX80_RS01615	COG1733	regulation of RNA biosynthetic process
NX80_RS01670	COG0129	dihydroxy-acid dehydratase activity
NX80_RS01685	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
NX80_RS01740	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
NX80_RS01745	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
NX80_RS01770	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
NX80_RS01775	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
NX80_RS01785	COG3485	protocatechuate 3,4-dioxygenase
NX80_RS01790	COG3485	protocatechuate 3,4-dioxygenase
NX80_RS01800	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
NX80_RS01805	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NX80_RS01810	COG1414	Transcriptional regulator
NX80_RS01825	COG0445	tRNA wobble uridine modification
NX80_RS01880	COG0156	8-amino-7-oxononanoate synthase activity
NX80_RS01885	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
NX80_RS01890	COG1040	competence protein
NX80_RS01925	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
NX80_RS02015	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
NX80_RS02090	COG1511	domain protein
NX80_RS02090	COG3264	Mechanosensitive ion channel
NX80_RS02095	COG1368	sulfuric ester hydrolase activity
NX80_RS02105	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
NX80_RS02110	COG2354	Protein conserved in bacteria
NX80_RS02125	COG0297	glycogen (starch) synthase activity
NX80_RS02130	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
NX80_RS02135	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
NX80_RS02160	COG0702	epimerase
NX80_RS02165	COG1028	Short-chain dehydrogenase reductase Sdr
NX80_RS02195	COG0513	Belongs to the DEAD box helicase family
NX80_RS02210	COG0508	dehydrogenase complex catalyzes the overall conversion of
NX80_RS02225	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
NX80_RS02245	COG3483	tryptophan 2,3-dioxygenase activity
NX80_RS02255	COG3104	oligopeptide transport
NX80_RS02275	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
NX80_RS02330	COG1320	monovalent cation:proton antiporter activity
NX80_RS02335	COG2212	antiporter activity
NX80_RS02345	COG0651	ATP synthesis coupled electron transport
NX80_RS02350	COG1006	Multisubunit Na H antiporter MnhC subunit
NX80_RS02355	COG2111	Na H antiporter
NX80_RS02355	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
NX80_RS02455	COG0339	signal peptide processing
NX80_RS02480	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
NX80_RS02485	COG0546	phosphoglycolate phosphatase activity
NX80_RS02495	COG1956	GAF domain-containing protein
NX80_RS02500	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
NX80_RS02510	COG0720	synthase
NX80_RS02520	COG0513	Belongs to the DEAD box helicase family
NX80_RS02535	COG0625	glutathione transferase activity
NX80_RS02565	COG0626	cystathionine gamma-synthase activity
NX80_RS02600	COG0438	transferase activity, transferring glycosyl groups
NX80_RS02645	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NX80_RS02655	COG0277	FAD linked oxidase domain protein
NX80_RS02660	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
NX80_RS02660	COG0546	phosphoglycolate phosphatase activity
NX80_RS02675	COG2086	electron transfer activity
NX80_RS02700	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
NX80_RS02700	COG0662	Cupin 2, conserved barrel domain protein
NX80_RS02705	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NX80_RS02745	COG3218	ABC-type transport auxiliary lipoprotein component
NX80_RS02745	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
NX80_RS02750	COG1127	ABC transporter
NX80_RS02755	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
NX80_RS02770	COG0442	prolyl-tRNA aminoacylation
NX80_RS02780	COG1183	phosphatidylcholine synthase activity
NX80_RS02790	COG0456	acetyltransferase
NX80_RS02795	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
NX80_RS02815	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
NX80_RS02830	COG0218	Necessary for normal cell division and for the maintenance of normal septation
NX80_RS02855	COG2205	protein histidine kinase activity
NX80_RS02860	COG0745	RESPONSE REGULATOR receiver
NX80_RS02880	COG3791	Glutathione-dependent formaldehyde-activating
NX80_RS02935	COG0402	S-adenosylhomocysteine deaminase activity
NX80_RS02940	COG3964	amidohydrolase
NX80_RS02955	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
NX80_RS02960	COG0726	polysaccharide deacetylase
NX80_RS02975	COG0436	Aminotransferase
NX80_RS02980	COG1162	GTPase activity
NX80_RS03005	COG2211	Major facilitator Superfamily
NX80_RS03015	COG1609	Transcriptional regulator
NX80_RS03020	COG1028	Short-chain dehydrogenase reductase Sdr
NX80_RS03025	COG2851	Citrate transporter
NX80_RS03050	COG0642	Histidine kinase
NX80_RS03060	COG2197	response regulator
NX80_RS03075	COG0667	Aldo Keto reductase
NX80_RS03080	COG0583	DNA-binding transcription factor activity
NX80_RS03095	COG4191	Histidine kinase
NX80_RS03105	COG1301	dicarboxylic acid transport
NX80_RS03110	COG0281	malic enzyme
NX80_RS03110	COG0280	phosphate acetyltransferase
NX80_RS03205	COG1560	Kdo2-lipid A biosynthetic process
NX80_RS03210	COG1519	Transferase
NX80_RS03215	COG1538	Outer membrane efflux protein
NX80_RS03220	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
NX80_RS03230	COG3706	GGDEF domain
NX80_RS03245	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
NX80_RS03250	COG0066	3-isopropylmalate dehydratase activity
NX80_RS03260	COG0473	3-isopropylmalate dehydrogenase activity
NX80_RS03265	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NX80_RS03285	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
NX80_RS03295	COG0840	transmembrane signaling receptor activity
NX80_RS03310	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
NX80_RS03315	COG3710	Transcriptional regulator
NX80_RS03335	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
NX80_RS03345	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
NX80_RS03365	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
NX80_RS03375	COG3781	membrane
NX80_RS03380	COG0671	phosphoesterase, PA-phosphatase related
NX80_RS03390	COG1028	Short-chain dehydrogenase reductase Sdr
NX80_RS03400	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NX80_RS03405	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NX80_RS03435	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NX80_RS03440	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
NX80_RS03450	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
NX80_RS03475	COG0352	thiamine-phosphate diphosphorylase activity
NX80_RS03480	COG1773	rubredoxin
NX80_RS03485	COG2912	Transglutaminase-like superfamily
NX80_RS03505	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
NX80_RS03530	COG0006	proline dipeptidase activity
NX80_RS03540	COG0006	proline dipeptidase activity
NX80_RS03555	COG0635	Involved in the biosynthesis of porphyrin-containing compound
NX80_RS03570	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
NX80_RS03575	COG1561	YicC-like family, N-terminal region
NX80_RS03590	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NX80_RS03600	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
NX80_RS03605	COG1957	nucleoside hydrolase
NX80_RS03625	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
NX80_RS03655	COG0714	Associated with various cellular activities
NX80_RS03675	COG2304	oxidoreductase activity
NX80_RS03690	COG1301	dicarboxylic acid transport
NX80_RS03695	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
NX80_RS03705	COG4773	Receptor
NX80_RS03710	COG0583	DNA-binding transcription factor activity
NX80_RS03715	COG1028	Short-chain dehydrogenase reductase Sdr
NX80_RS03720	COG0739	heme binding
NX80_RS03725	COG1376	ErfK ybiS ycfS ynhG family protein
NX80_RS03765	COG4149	molybdate abc transporter
NX80_RS03770	COG0725	ABC transporter, periplasmic molybdate-binding protein
NX80_RS03775	COG3453	Protein conserved in bacteria
NX80_RS03775	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NX80_RS03785	COG3047	cAMP biosynthetic process
NX80_RS03805	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
NX80_RS03840	COG0469	pyruvate kinase activity
NX80_RS03850	COG3588	fructose-bisphosphate aldolase
NX80_RS03855	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
NX80_RS03875	COG0583	DNA-binding transcription factor activity
NX80_RS03890	COG2205	protein histidine kinase activity
NX80_RS03890	COG2198	Histidine kinase
NX80_RS03890	COG0784	Response regulator, receiver
NX80_RS03910	COG0175	sulfate reduction
NX80_RS03915	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NX80_RS03920	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
NX80_RS03925	COG0175	sulfate reduction
NX80_RS03930	COG0529	Catalyzes the synthesis of activated sulfate
NX80_RS03930	COG2895	sulfate adenylyltransferase (ATP) activity
NX80_RS03940	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NX80_RS04000	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NX80_RS04015	COG4948	Mandelate Racemase Muconate Lactonizing
NX80_RS04020	COG3250	beta-galactosidase activity
NX80_RS04045	COG1609	Transcriptional regulator
NX80_RS04055	COG1970	mechanosensitive ion channel activity
NX80_RS04075	COG3273	potassium ion transport
NX80_RS04075	COG0471	metal ion transport
NX80_RS04080	COG0220	tRNA (guanine-N7-)-methyltransferase activity
NX80_RS04085	COG2022	thiamine diphosphate biosynthetic process
NX80_RS04160	COG0745	RESPONSE REGULATOR receiver
NX80_RS04190	COG0237	dephospho-CoA kinase activity
NX80_RS04195	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
NX80_RS04230	COG0045	succinate-CoA ligase (ADP-forming) activity
NX80_RS04235	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
NX80_RS04250	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
NX80_RS04250	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NX80_RS04280	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
NX80_RS04290	COG0537	adenosine 5'-monophosphoramidase activity
NX80_RS04310	COG0714	Associated with various cellular activities
NX80_RS04330	COG1399	metal-binding, possibly nucleic acid-binding protein
NX80_RS04340	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NX80_RS04355	COG1028	Short-chain dehydrogenase reductase Sdr
NX80_RS04360	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NX80_RS04370	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
NX80_RS04375	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
NX80_RS04395	COG4115	mRNA cleavage
NX80_RS04400	COG2161	toxin-antitoxin pair type II binding
NX80_RS04410	COG3829	transcription factor binding
NX80_RS04430	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
NX80_RS04460	COG2373	Large extracellular alpha-helical protein
NX80_RS04480	COG4953	penicillin-binding protein 1C
NX80_RS04490	COG0678	peroxiredoxin activity
NX80_RS04510	COG0330	HflC and HflK could
NX80_RS04515	COG0330	HflC and HflK could
NX80_RS04520	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
NX80_RS04525	COG0308	aminopeptidase N
NX80_RS04570	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
NX80_RS04615	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
NX80_RS04625	COG3387	PFAM Glycoside hydrolase 15-related
NX80_RS04645	COG3039	Transposase
NX80_RS04675	COG3537	Alpha-1,2-mannosidase
NX80_RS04680	COG4221	oxidoreductase activity
NX80_RS04700	COG3287	FIST C domain
NX80_RS04700	COG2200	EAL domain
NX80_RS04700	COG2199	diguanylate cyclase activity
NX80_RS04740	COG1529	Aldehyde oxidase and xanthine dehydrogenase
NX80_RS04745	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
NX80_RS04750	COG2080	2 iron, 2 sulfur cluster binding
NX80_RS04800	COG0587	DNA-directed DNA polymerase activity
NX80_RS04835	COG1297	OPT oligopeptide transporter protein
NX80_RS04855	COG0823	Involved in the tonB-independent uptake of proteins
NX80_RS04855	COG1506	peptidase
NX80_RS04885	COG1917	Cupin 2, conserved barrel domain protein
NX80_RS04885	COG2207	Transcriptional regulator
NX80_RS04965	COG0753	catalase activity
NX80_RS04970	COG0656	L-ascorbic acid biosynthetic process
NX80_RS04980	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NX80_RS04980	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NX80_RS05000	COG2814	Major facilitator Superfamily
NX80_RS05015	COG2194	sulfuric ester hydrolase activity
NX80_RS05030	COG0745	RESPONSE REGULATOR receiver
NX80_RS05035	COG0642	Histidine kinase
NX80_RS05045	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
NX80_RS05050	COG2894	cell division
NX80_RS05055	COG0850	regulation of cytokinetic process
NX80_RS05065	COG4585	Histidine kinase
NX80_RS05070	COG2197	response regulator
NX80_RS05085	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
NX80_RS05115	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
NX80_RS05130	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
NX80_RS05160	COG1946	Acyl-CoA thioesterase
NX80_RS05175	COG0824	Thioesterase
NX80_RS05180	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
NX80_RS05185	COG0261	This protein binds to 23S rRNA in the presence of protein L20
NX80_RS05190	COG0211	Belongs to the bacterial ribosomal protein bL27 family
NX80_RS05195	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
NX80_RS05200	COG0268	Binds directly to 16S ribosomal RNA
NX80_RS05205	COG0728	peptidoglycan biosynthetic process
NX80_RS05210	COG0196	riboflavin kinase activity
NX80_RS05215	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
NX80_RS05220	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
NX80_RS05240	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
NX80_RS05245	COG1845	cytochrome c oxidase, subunit III
NX80_RS05250	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
NX80_RS05265	COG3152	Membrane
NX80_RS05280	COG2207	Transcriptional regulator
NX80_RS05285	COG0326	Molecular chaperone. Has ATPase activity
NX80_RS05295	COG1366	Belongs to the anti-sigma-factor antagonist family
NX80_RS05300	COG1366	Belongs to the anti-sigma-factor antagonist family
NX80_RS05305	COG2172	sigma factor antagonist activity
NX80_RS05340	COG5507	3-demethylubiquinone-9 3-methyltransferase
NX80_RS05345	COG2205	protein histidine kinase activity
NX80_RS05355	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
NX80_RS05360	COG3437	response regulator, receiver
NX80_RS05360	COG3850	Histidine kinase
NX80_RS05360	COG2205	protein histidine kinase activity
NX80_RS05360	COG4999	Histidine kinase
NX80_RS05365	COG4191	Histidine kinase
NX80_RS05365	COG0784	Response regulator, receiver
NX80_RS05385	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
NX80_RS05390	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
NX80_RS05400	COG2070	2-Nitropropane dioxygenase
NX80_RS05405	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NX80_RS05410	COG0228	four-way junction DNA binding
NX80_RS05415	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
NX80_RS05420	COG0336	Belongs to the RNA methyltransferase TrmD family
NX80_RS05430	COG0534	Mate efflux family protein
NX80_RS05440	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
NX80_RS05455	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
NX80_RS05465	COG1028	Short-chain dehydrogenase reductase Sdr
NX80_RS05470	COG1028	Short-chain dehydrogenase reductase Sdr
NX80_RS05475	COG1028	Short-chain dehydrogenase reductase Sdr
NX80_RS05490	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
NX80_RS05505	COG3250	beta-galactosidase activity
NX80_RS05510	COG3867	Arabinogalactan endo-beta-1,4-galactanase
NX80_RS05530	COG1960	acyl-CoA dehydrogenase activity
NX80_RS05535	COG1024	Enoyl-CoA hydratase
NX80_RS05560	COG1024	Enoyl-CoA hydratase
NX80_RS05560	COG1250	3-hydroxyacyl-CoA dehydrogenase
NX80_RS05575	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NX80_RS05595	COG0571	ribonuclease III activity
NX80_RS05600	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
NX80_RS05605	COG1381	Involved in DNA repair and RecF pathway recombination
NX80_RS05620	COG2954	triphosphatase activity
NX80_RS05630	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
NX80_RS05635	COG3046	protein related to deoxyribodipyrimidine photolyase
NX80_RS05640	COG1472	Belongs to the glycosyl hydrolase 3 family
NX80_RS05650	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
NX80_RS05655	COG1278	Cold shock
NX80_RS05660	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NX80_RS05675	COG1201	RNA secondary structure unwinding
NX80_RS05680	COG1793	dna ligase
NX80_RS05690	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
NX80_RS05690	COG1793	dna ligase
NX80_RS05705	COG5001	Diguanylate cyclase
NX80_RS05725	COG0183	Belongs to the thiolase family
NX80_RS05745	COG1451	nucleotide metabolic process
NX80_RS05755	COG5487	UPF0391 membrane protein
NX80_RS05765	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
NX80_RS05800	COG1047	Peptidyl-prolyl cis-trans
NX80_RS05815	COG2824	Alkylphosphonate utilization operon protein PhnA
NX80_RS05830	COG1902	pentaerythritol trinitrate reductase activity
NX80_RS05835	COG2814	Major facilitator Superfamily
NX80_RS05870	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
NX80_RS05870	COG0392	lysyltransferase activity
NX80_RS05880	COG0251	oxidation-reduction process
NX80_RS05885	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
NX80_RS05900	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
NX80_RS05925	COG1595	DNA-templated transcription, initiation
NX80_RS05940	COG2878	Part of a membrane complex involved in electron transport
NX80_RS05950	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NX80_RS05950	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NX80_RS05960	COG0346	lactoylglutathione lyase activity
NX80_RS05965	COG0833	amino acid
NX80_RS05970	COG2040	homocysteine
NX80_RS05980	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
NX80_RS06045	COG0825	malonyl-CoA metabolic process
NX80_RS06060	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
NX80_RS06065	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NX80_RS06070	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NX80_RS06075	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
NX80_RS06080	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NX80_RS06095	COG0750	zinc metalloprotease
NX80_RS06100	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
NX80_RS06115	COG0233	cytoplasmic translational termination
NX80_RS06120	COG0528	UMP kinase activity
NX80_RS06125	COG3706	GGDEF domain
NX80_RS06130	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
NX80_RS06175	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
NX80_RS06190	COG1393	Belongs to the ArsC family
NX80_RS06200	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NX80_RS06205	COG0367	asparagine synthase
NX80_RS06215	COG4774	siderophore transport
NX80_RS06235	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
NX80_RS06265	COG1566	PFAM secretion protein HlyD family protein
NX80_RS06270	COG2814	Major facilitator Superfamily
NX80_RS06345	COG0339	signal peptide processing
NX80_RS06355	COG0386	Belongs to the glutathione peroxidase family
NX80_RS06425	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
NX80_RS06430	COG0084	hydrolase, TatD family'
NX80_RS06450	COG1960	acyl-CoA dehydrogenase activity
NX80_RS06470	COG0367	asparagine synthase
NX80_RS06480	COG0305	Participates in initiation and elongation during chromosome replication
NX80_RS06485	COG0415	Belongs to the DNA photolyase family
NX80_RS06500	COG0583	DNA-binding transcription factor activity
NX80_RS06515	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NX80_RS06535	COG3706	GGDEF domain
NX80_RS06545	COG3706	GGDEF domain
NX80_RS06615	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
NX80_RS06625	COG2914	Belongs to the UPF0125 (RnfH) family
NX80_RS06635	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
NX80_RS06645	COG0497	DNA recombination
NX80_RS06650	COG1420	regulation of RNA biosynthetic process
NX80_RS06655	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
NX80_RS06660	COG0443	Heat shock 70 kDa protein
NX80_RS06665	COG0484	heat shock protein binding
NX80_RS06670	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
NX80_RS06700	COG0583	DNA-binding transcription factor activity
NX80_RS06710	COG1132	(ABC) transporter
NX80_RS06745	COG2850	peptidyl-arginine hydroxylation
NX80_RS06780	COG1253	flavin adenine dinucleotide binding
NX80_RS06810	COG1131	(ABC) transporter
NX80_RS06815	COG1725	Transcriptional regulator
NX80_RS06825	COG0386	Belongs to the glutathione peroxidase family
NX80_RS06840	COG2900	Belongs to the SlyX family
NX80_RS06870	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NX80_RS06885	COG0646	methionine synthase
NX80_RS06885	COG1410	methionine synthase
NX80_RS06890	COG2226	methyltransferase
NX80_RS06895	COG1960	acyl-CoA dehydrogenase activity
NX80_RS06915	COG0557	exoribonuclease II activity
NX80_RS06925	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NX80_RS06930	COG3706	GGDEF domain
NX80_RS06935	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
NX80_RS06945	COG0704	Plays a role in the regulation of phosphate uptake
NX80_RS06950	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
NX80_RS06955	COG0581	inorganic phosphate transmembrane transporter activity
NX80_RS06960	COG0573	inorganic phosphate transmembrane transporter activity
NX80_RS06965	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
NX80_RS06995	COG0659	secondary active sulfate transmembrane transporter activity
NX80_RS07000	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
NX80_RS07010	COG1024	Enoyl-CoA hydratase
NX80_RS07020	COG0494	nUDIX hydrolase
NX80_RS07065	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
NX80_RS07065	COG0116	Belongs to the methyltransferase superfamily
NX80_RS07070	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
NX80_RS07085	COG0667	Aldo Keto reductase
NX80_RS07095	COG2925	Exonuclease
NX80_RS07100	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NX80_RS07105	COG3844	kynureninase activity
NX80_RS07120	COG0288	reversible hydration of carbon dioxide
NX80_RS07125	COG2808	Putative FMN-binding domain
NX80_RS07145	COG0017	Asparaginyl-tRNA synthetase
NX80_RS07150	COG0316	Belongs to the HesB IscA family
NX80_RS07155	COG0360	Binds together with S18 to 16S ribosomal RNA
NX80_RS07175	COG3115	cell septum assembly
NX80_RS07185	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NX80_RS07190	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
NX80_RS07195	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
NX80_RS07210	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
NX80_RS07220	COG4993	Dehydrogenase
NX80_RS07245	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
NX80_RS07255	COG2986	histidine ammonia-lyase
NX80_RS07260	COG1228	amidohydrolase
NX80_RS07295	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
NX80_RS07300	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
NX80_RS07305	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
NX80_RS07310	COG0077	Prephenate dehydratase
NX80_RS07310	COG1605	Chorismate mutase
NX80_RS07315	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
NX80_RS07330	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
NX80_RS07340	COG0583	DNA-binding transcription factor activity
NX80_RS07445	COG0433	COG0433 Predicted ATPase
NX80_RS07455	COG0688	phosphatidylethanolamine metabolic process
NX80_RS07460	COG0688	phosphatidylethanolamine metabolic process
NX80_RS07470	COG2890	protein-(glutamine-N5) methyltransferase activity
NX80_RS07475	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
NX80_RS07480	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NX80_RS07485	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
NX80_RS07505	COG0101	tRNA pseudouridine synthase activity
NX80_RS07510	COG0135	phosphoribosylanthranilate isomerase activity
NX80_RS07520	COG0133	tryptophan synthase activity
NX80_RS07540	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
NX80_RS07545	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NX80_RS07590	COG0149	triose-phosphate isomerase activity
NX80_RS07605	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NX80_RS07615	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NX80_RS07620	COG0649	NAD binding
NX80_RS07625	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
NX80_RS07630	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
NX80_RS07635	COG1034	ATP synthesis coupled electron transport
NX80_RS07640	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
NX80_RS07645	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NX80_RS07670	COG1007	ATP synthesis coupled electron transport
NX80_RS07680	COG0779	Required for maturation of 30S ribosomal subunits
NX80_RS07685	COG0195	Participates in both transcription termination and antitermination
NX80_RS07690	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
NX80_RS07695	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
NX80_RS07705	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
NX80_RS07710	COG1185	polyribonucleotide nucleotidyltransferase activity
NX80_RS07740	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
NX80_RS07745	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
NX80_RS07755	COG2095	MarC family integral membrane protein
NX80_RS07765	COG1611	Belongs to the LOG family
NX80_RS07770	COG3275	phosphorelay sensor kinase activity
NX80_RS07815	COG0556	nucleotide-excision repair
NX80_RS07830	COG0477	Major facilitator Superfamily
NX80_RS07850	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
NX80_RS07870	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
NX80_RS07880	COG3158	transport of potassium into the cell
NX80_RS07885	COG2255	four-way junction helicase activity
NX80_RS07890	COG0824	Thioesterase
NX80_RS07900	COG0848	biopolymer transport protein
NX80_RS07910	COG0823	Involved in the tonB-independent uptake of proteins
NX80_RS07915	COG2885	chlorophyll binding
NX80_RS07925	COG0602	queuosine metabolic process
NX80_RS08210	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
NX80_RS08275	COG0514	ATP-dependent DNA helicase (RecQ)
NX80_RS08280	COG0783	Belongs to the Dps family
NX80_RS08285	COG1643	Atp-dependent helicase
NX80_RS08300	COG0837	glucose binding
NX80_RS08330	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
NX80_RS08335	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
NX80_RS08345	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NX80_RS08360	COG1215	transferase activity, transferring glycosyl groups
NX80_RS08370	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NX80_RS08380	COG1199	ATP-dependent helicase activity
NX80_RS08390	COG1397	ADP-ribosylglycohydrolase
NX80_RS08400	COG0189	ligase activity
NX80_RS08415	COG0835	chemotaxis
NX80_RS08420	COG0840	transmembrane signaling receptor activity
NX80_RS08425	COG0643	Histidine kinase
NX80_RS08425	COG2198	Histidine kinase
NX80_RS08425	COG0784	Response regulator, receiver
NX80_RS08465	COG1446	asparaginase
NX80_RS08470	COG3142	Participates in the control of copper homeostasis
NX80_RS08510	COG3537	Alpha-1,2-mannosidase
NX80_RS08570	COG1472	Belongs to the glycosyl hydrolase 3 family
NX80_RS08610	COG1388	LysM domain
NX80_RS08610	COG3858	chitin binding
NX80_RS08625	COG0837	glucose binding
NX80_RS08630	COG1385	rRNA (uridine-N3-)-methyltransferase activity
NX80_RS08640	COG0494	nUDIX hydrolase
NX80_RS08650	COG3956	TIGRFAM MazG family protein
NX80_RS08655	COG1742	UPF0060 membrane protein
NX80_RS08670	COG0404	The glycine cleavage system catalyzes the degradation of glycine
NX80_RS08675	COG0509	glycine decarboxylation via glycine cleavage system
NX80_RS08715	COG1960	acyl-CoA dehydrogenase activity
NX80_RS08725	COG1309	transcriptional regulator
NX80_RS08730	COG4771	TonB-dependent receptor
NX80_RS08740	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
NX80_RS08750	COG0463	Glycosyl transferase, family 2
NX80_RS08775	COG1272	protein, Hemolysin III
NX80_RS08780	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
NX80_RS08785	COG0739	heme binding
NX80_RS08790	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
NX80_RS08795	COG0626	cystathionine gamma-synthase activity
NX80_RS08800	COG0460	homoserine dehydrogenase
NX80_RS08800	COG0527	aspartate kinase activity
NX80_RS08810	COG1760	l-serine dehydratase
NX80_RS08840	COG2353	YceI-like domain
NX80_RS08845	COG2205	protein histidine kinase activity
NX80_RS08845	COG0784	Response regulator, receiver
NX80_RS08845	COG2198	Histidine kinase
NX80_RS08850	COG0784	Response regulator, receiver
NX80_RS08850	COG5002	protein histidine kinase activity
NX80_RS08865	COG2814	Major facilitator Superfamily
NX80_RS08870	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
NX80_RS08885	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
NX80_RS08890	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
NX80_RS08895	COG0259	pyridoxamine-phosphate oxidase activity
NX80_RS08905	COG1842	Phage shock protein A
NX80_RS08930	COG0754	glutathionylspermidine amidase activity
NX80_RS08940	COG2814	Major facilitator Superfamily
NX80_RS09015	COG0531	amino acid
NX80_RS09020	COG2197	response regulator
NX80_RS09035	COG1113	amino acid transport
NX80_RS09045	COG1271	oxidase subunit
NX80_RS09050	COG1294	oxidase, subunit
NX80_RS09065	COG2239	Acts as a magnesium transporter
NX80_RS09075	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NX80_RS09080	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
NX80_RS09090	COG1660	Displays ATPase and GTPase activities
NX80_RS09100	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NX80_RS09115	COG1137	ATPase activity
NX80_RS09120	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
NX80_RS09130	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
NX80_RS09140	COG0271	Belongs to the BolA IbaG family
NX80_RS09145	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
NX80_RS09170	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
NX80_RS09180	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
NX80_RS09190	COG0628	permease
NX80_RS09205	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
NX80_RS09210	COG3178	'Phosphotransferase
NX80_RS09220	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NX80_RS09225	COG1555	photosystem II stabilization
NX80_RS09235	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
NX80_RS09240	COG1477	protein flavinylation
NX80_RS09265	COG3128	pkhd-type hydroxylase
NX80_RS09270	COG4774	siderophore transport
NX80_RS09275	COG2146	nitrite reductase [NAD(P)H] activity
NX80_RS09280	COG0456	acetyltransferase
NX80_RS09290	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
NX80_RS09295	COG0719	Fe-S assembly protein
NX80_RS09300	COG0396	ATPase activity
NX80_RS09305	COG0719	Fe-S assembly protein
NX80_RS09310	COG1959	2 iron, 2 sulfur cluster binding
NX80_RS09320	COG0693	protein deglycase activity
NX80_RS09340	COG4942	peptidase
NX80_RS09355	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
NX80_RS09380	COG0519	Catalyzes the synthesis of GMP from XMP
NX80_RS09390	COG1678	Uncharacterized ACR, COG1678
NX80_RS09395	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
NX80_RS09400	COG0540	Belongs to the ATCase OTCase family
NX80_RS09460	COG0384	phenazine biosynthesis protein PhzF
NX80_RS09465	COG0384	phenazine biosynthesis protein PhzF
NX80_RS09470	COG0527	aspartate kinase activity
NX80_RS09495	COG0142	geranyltranstransferase activity
NX80_RS09500	COG0629	single-stranded DNA binding
NX80_RS09505	COG2203	Gaf domain
NX80_RS09505	COG3706	GGDEF domain
NX80_RS09505	COG4251	negative regulation of phosphorylation
NX80_RS09505	COG5001	Diguanylate cyclase
NX80_RS09510	COG3321	synthase
NX80_RS09510	COG1028	Short-chain dehydrogenase reductase Sdr
NX80_RS09510	COG0604	alcohol dehydrogenase
NX80_RS09515	COG2080	2 iron, 2 sulfur cluster binding
NX80_RS09520	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
NX80_RS09525	COG1529	Aldehyde oxidase and xanthine dehydrogenase
NX80_RS09530	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
NX80_RS09565	COG2879	small protein
NX80_RS09570	COG1966	Carbon starvation protein
NX80_RS09575	COG1741	Belongs to the pirin family
NX80_RS09595	COG1741	Belongs to the pirin family
NX80_RS09600	COG1515	deoxyribonuclease V activity
NX80_RS09605	COG0588	phosphoglycerate mutase activity
NX80_RS09615	COG3590	peptidase
NX80_RS09620	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NX80_RS09630	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
NX80_RS09640	COG0835	chemotaxis
NX80_RS09645	COG0840	transmembrane signaling receptor activity
NX80_RS09650	COG0643	Histidine kinase
NX80_RS09650	COG2198	Histidine kinase
NX80_RS09660	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
NX80_RS09670	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
NX80_RS09675	COG0745	RESPONSE REGULATOR receiver
NX80_RS09685	COG2205	protein histidine kinase activity
NX80_RS09695	COG4452	Inner membrane protein CreD
NX80_RS09720	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NX80_RS09725	COG0735	belongs to the Fur family
NX80_RS09760	COG3039	Transposase
NX80_RS09775	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NX80_RS09815	COG2207	Transcriptional regulator
NX80_RS09835	COG0583	DNA-binding transcription factor activity
NX80_RS09840	COG2814	Major facilitator Superfamily
NX80_RS09845	COG0667	Aldo Keto reductase
NX80_RS09960	COG5001	Diguanylate cyclase
NX80_RS09960	COG5002	protein histidine kinase activity
NX80_RS09965	COG1187	pseudouridine synthase activity
NX80_RS09995	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
NX80_RS10005	COG0475	glutathione-regulated potassium exporter activity
NX80_RS10010	COG5002	protein histidine kinase activity
NX80_RS10010	COG5000	phosphorelay sensor kinase activity
NX80_RS10015	COG0745	RESPONSE REGULATOR receiver
NX80_RS10020	COG1538	Outer membrane efflux protein
NX80_RS10045	COG1132	(ABC) transporter
NX80_RS10095	COG2155	Conserved Protein
NX80_RS10110	COG3118	belongs to the thioredoxin family
NX80_RS10140	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
NX80_RS10160	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
NX80_RS10175	COG2968	Membrane
NX80_RS10185	COG1530	ribonuclease E activity
NX80_RS10190	COG3164	Protein of unknown function
NX80_RS10200	COG0312	modulator of DNA gyrase
NX80_RS10210	COG0312	modulator of DNA gyrase
NX80_RS10220	COG4104	PAAR repeat-containing protein
NX80_RS10225	COG0142	geranyltranstransferase activity
NX80_RS10230	COG1722	exodeoxyribonuclease VII activity
NX80_RS10235	COG0037	tRNA processing
NX80_RS10240	COG1785	Belongs to the alkaline phosphatase family
NX80_RS10245	COG1301	dicarboxylic acid transport
NX80_RS10260	COG0791	NLP P60 protein
NX80_RS10265	COG0791	NLP P60 protein
NX80_RS10270	COG1047	Peptidyl-prolyl cis-trans
NX80_RS10275	COG2311	Membrane
NX80_RS10280	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NX80_RS10285	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NX80_RS10305	COG3590	peptidase
NX80_RS10310	COG3590	peptidase
NX80_RS10330	COG0489	protein tyrosine kinase activity
NX80_RS10340	COG0717	Belongs to the dCTP deaminase family
NX80_RS10375	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NX80_RS10385	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
NX80_RS10465	COG0840	transmembrane signaling receptor activity
NX80_RS10490	COG0784	Response regulator, receiver
NX80_RS10490	COG5002	protein histidine kinase activity
NX80_RS10490	COG2205	protein histidine kinase activity
NX80_RS10495	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
NX80_RS10515	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NX80_RS10525	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
NX80_RS10535	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
NX80_RS10605	COG2244	polysaccharide biosynthetic process
NX80_RS10630	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
NX80_RS10645	COG0438	transferase activity, transferring glycosyl groups
NX80_RS10660	COG1136	(ABC) transporter
NX80_RS10665	COG1132	(ABC) transporter
NX80_RS10670	COG0477	Major facilitator Superfamily
NX80_RS10680	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NX80_RS10695	COG1253	flavin adenine dinucleotide binding
NX80_RS10710	COG0306	phosphate transporter
NX80_RS10715	COG1434	Gram-negative-bacterium-type cell wall biogenesis
NX80_RS10725	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
NX80_RS10730	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
NX80_RS10745	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
NX80_RS10800	COG0438	transferase activity, transferring glycosyl groups
NX80_RS10805	COG0438	transferase activity, transferring glycosyl groups
NX80_RS10815	COG0438	transferase activity, transferring glycosyl groups
NX80_RS10840	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NX80_RS10845	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NX80_RS10850	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NX80_RS10870	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
NX80_RS10880	COG1960	acyl-CoA dehydrogenase activity
NX80_RS10890	COG3040	lipid binding
NX80_RS10915	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
NX80_RS10920	COG4191	Histidine kinase
NX80_RS10920	COG0784	Response regulator, receiver
NX80_RS10940	COG0552	protein localization to endoplasmic reticulum
NX80_RS10950	COG3938	Belongs to the proline racemase family
NX80_RS10955	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NX80_RS10970	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NX80_RS10980	COG0006	proline dipeptidase activity
NX80_RS10995	COG0531	amino acid
NX80_RS11065	COG4206	TonB-dependent receptor
NX80_RS11095	COG3039	Transposase
NX80_RS11100	COG0326	Molecular chaperone. Has ATPase activity
NX80_RS11105	COG0742	ribosomal rna small subunit methyltransferase
NX80_RS11110	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
NX80_RS11125	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
NX80_RS11130	COG0405	Gamma-glutamyltransferase
NX80_RS11145	COG3291	Pkd domain containing protein
NX80_RS11150	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
NX80_RS11190	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
NX80_RS11195	COG0343	queuine tRNA-ribosyltransferase activity
NX80_RS11200	COG1862	Preprotein translocase
NX80_RS11210	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NX80_RS11250	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NX80_RS11250	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NX80_RS11255	COG1105	Belongs to the carbohydrate kinase PfkB family
NX80_RS11260	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
NX80_RS11260	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NX80_RS11265	COG1609	Transcriptional regulator
NX80_RS11310	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NX80_RS11315	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NX80_RS11325	COG2902	Dehydrogenase
NX80_RS11330	COG0477	Major facilitator Superfamily
NX80_RS11345	COG5002	protein histidine kinase activity
NX80_RS11345	COG0784	Response regulator, receiver
NX80_RS11345	COG2205	protein histidine kinase activity
NX80_RS11350	COG2733	membrane
NX80_RS11360	COG1121	(ABC) transporter
NX80_RS11375	COG2223	nitrite transmembrane transporter activity
NX80_RS11380	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
NX80_RS11385	COG0243	molybdopterin cofactor binding
NX80_RS11445	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NX80_RS11450	COG0174	glutamine synthetase
NX80_RS11470	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
NX80_RS11520	COG3842	ATPase activity
NX80_RS11525	COG1176	ABC-type spermidine putrescine transport system, permease component I
NX80_RS11530	COG1177	transmembrane transport
NX80_RS11535	COG1012	belongs to the aldehyde dehydrogenase family
NX80_RS11550	COG4535	Mg2 and Co2 transporter CorC
NX80_RS11575	COG1702	phosphate starvation-inducible protein PhoH
NX80_RS11595	COG0741	lytic transglycosylase activity
NX80_RS11600	COG0723	plastoquinol--plastocyanin reductase activity
NX80_RS11605	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
NX80_RS11610	COG2857	Cytochrome c1
NX80_RS11615	COG0625	glutathione transferase activity
NX80_RS11620	COG2969	positive regulation of protein catabolic process
NX80_RS11640	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
NX80_RS11645	COG1201	RNA secondary structure unwinding
NX80_RS11650	COG2094	Belongs to the DNA glycosylase MPG family
NX80_RS11655	COG0840	transmembrane signaling receptor activity
NX80_RS11660	COG0835	chemotaxis
NX80_RS11705	COG1262	PFAM Formylglycine-generating sulfatase enzyme
NX80_RS11720	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
NX80_RS11725	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
NX80_RS11725	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
NX80_RS11730	COG0802	atpase or kinase
NX80_RS11735	COG0860	N-Acetylmuramoyl-L-alanine amidase
NX80_RS11740	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
NX80_RS11765	COG1028	Short-chain dehydrogenase reductase Sdr
NX80_RS11775	COG0501	Belongs to the peptidase M48B family
NX80_RS11785	COG2081	HI0933 family
NX80_RS11795	COG1671	Belongs to the UPF0178 family
NX80_RS11805	COG0625	glutathione transferase activity
NX80_RS11815	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
NX80_RS11820	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
NX80_RS11825	COG0513	Belongs to the DEAD box helicase family
NX80_RS11850	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
NX80_RS11855	COG0483	inositol monophosphate 1-phosphatase activity
NX80_RS11870	COG5001	Diguanylate cyclase
NX80_RS11870	COG3300	MHYT domain
NX80_RS11875	COG1509	lysine 2,3-aminomutase activity
NX80_RS11880	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
NX80_RS11895	COG0402	S-adenosylhomocysteine deaminase activity
NX80_RS11900	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
NX80_RS11955	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
NX80_RS11975	COG2166	iron-sulfur cluster assembly
NX80_RS11990	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
NX80_RS11995	COG0137	argininosuccinate synthase activity
NX80_RS12005	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NX80_RS12010	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
NX80_RS12020	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
NX80_RS12025	COG0165	Argininosuccinate lyase
NX80_RS12080	COG4988	ABC transporter
NX80_RS12085	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
NX80_RS12095	COG1278	Cold shock
NX80_RS12125	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
NX80_RS12145	COG4133	protoheme IX ABC transporter activity
NX80_RS12150	COG0436	Aminotransferase
NX80_RS12175	COG1187	pseudouridine synthase activity
NX80_RS12180	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
NX80_RS12185	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
NX80_RS12190	COG2350	Protein conserved in bacteria
NX80_RS12210	COG3012	SEC-C Motif Domain Protein
NX80_RS12210	COG3318	Belongs to the UPF0149 family
NX80_RS12230	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
NX80_RS12265	COG3504	Conjugal transfer protein
NX80_RS12270	COG2948	multi-organism process
NX80_RS12315	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
NX80_RS12430	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
NX80_RS12450	COG3318	Belongs to the UPF0149 family
NX80_RS12450	COG3012	SEC-C Motif Domain Protein
NX80_RS12470	COG1175	transmembrane transport
NX80_RS12475	COG0395	ABC-type sugar transport system, permease component
NX80_RS12500	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NX80_RS12510	COG2957	Belongs to the agmatine deiminase family
NX80_RS12530	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
NX80_RS12535	COG0539	negative regulation of cytoplasmic translation
NX80_RS12540	COG0776	regulation of translation
NX80_RS12550	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
NX80_RS12565	COG1210	Utp--glucose-1-phosphate uridylyltransferase
NX80_RS12580	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
NX80_RS12595	COG3002	Belongs to the UPF0753 family
NX80_RS12600	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
NX80_RS12605	COG0583	DNA-binding transcription factor activity
NX80_RS12610	COG0583	DNA-binding transcription factor activity
NX80_RS12620	COG1028	Short-chain dehydrogenase reductase Sdr
NX80_RS12630	COG0583	DNA-binding transcription factor activity
NX80_RS12645	COG2197	response regulator
NX80_RS12660	COG1335	isochorismatase
NX80_RS12675	COG2814	Major facilitator Superfamily
NX80_RS12690	COG1914	H( )-stimulated, divalent metal cation uptake system
NX80_RS12705	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
NX80_RS12710	COG0668	transmembrane transport
NX80_RS12720	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
NX80_RS12735	COG1028	Short-chain dehydrogenase reductase Sdr
NX80_RS12740	COG1183	phosphatidylcholine synthase activity
NX80_RS12750	COG3243	poly(R)-hydroxyalkanoic acid synthase
NX80_RS12765	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NX80_RS12765	COG0723	plastoquinol--plastocyanin reductase activity
NX80_RS12775	COG2183	response to ionizing radiation
NX80_RS12785	COG0784	Response regulator, receiver
NX80_RS12785	COG2205	protein histidine kinase activity
NX80_RS12855	COG0800	Aldolase
NX80_RS12860	COG0129	dihydroxy-acid dehydratase activity
NX80_RS12865	COG0363	glucosamine-6-phosphate deaminase activity
NX80_RS12870	COG0837	glucose binding
NX80_RS12875	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
NX80_RS12905	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
NX80_RS12920	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
NX80_RS12925	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
NX80_RS12935	COG4591	ABC-type transport system involved in lipoprotein release permease component
NX80_RS12955	COG0811	peptide transport
NX80_RS12965	COG1132	(ABC) transporter
NX80_RS12970	COG1663	tetraacyldisaccharide 4'-kinase activity
NX80_RS12975	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
NX80_RS12980	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NX80_RS12990	COG0322	excinuclease ABC activity
NX80_RS13020	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
NX80_RS13065	COG3064	Membrane
NX80_RS13070	COG0428	transporter
NX80_RS13085	COG2154	pterin-4-alpha-carbinolamine dehydratase
NX80_RS13135	COG1858	cytochrome C peroxidase
NX80_RS13165	COG0515	serine threonine protein kinase
NX80_RS13170	COG0631	protein serine/threonine phosphatase activity
NX80_RS13205	COG3501	Rhs element vgr protein
NX80_RS13270	COG2801	Transposase and inactivated derivatives
NX80_RS13335	COG4566	intracellular signal transduction
NX80_RS13345	COG5001	Diguanylate cyclase
NX80_RS13360	COG3685	Protein conserved in bacteria
NX80_RS13385	COG1648	precorrin-2 dehydrogenase activity
NX80_RS13385	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
NX80_RS13395	COG0746	molybdenum cofactor guanylyltransferase activity
NX80_RS13400	COG0303	'Molybdopterin
NX80_RS13410	COG0708	Exodeoxyribonuclease III
NX80_RS13450	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
NX80_RS13455	COG0303	'Molybdopterin
NX80_RS13465	COG1160	GTP binding
NX80_RS13470	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
NX80_RS13490	COG0820	rRNA (adenine-C2-)-methyltransferase activity
NX80_RS13505	COG1024	Enoyl-CoA hydratase
NX80_RS13505	COG1250	3-hydroxyacyl-CoA dehydrogenase
NX80_RS13510	COG0183	Belongs to the thiolase family
NX80_RS13515	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
NX80_RS13520	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
NX80_RS13540	COG1674	ftsk spoiiie
NX80_RS13545	COG0492	ferredoxin-NADP+ reductase activity
NX80_RS13555	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
NX80_RS13565	COG0542	response to heat
NX80_RS13580	COG0482	sulfurtransferase activity
NX80_RS13610	COG4585	Histidine kinase
NX80_RS13620	COG5002	protein histidine kinase activity
NX80_RS13645	COG0835	chemotaxis
NX80_RS13645	COG0784	Response regulator, receiver
NX80_RS13655	COG1558	bacterial-type flagellum-dependent cell motility
NX80_RS13660	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
NX80_RS13670	COG4787	bacterial-type flagellum-dependent cell motility
NX80_RS13685	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
NX80_RS13690	COG1706	bacterial-type flagellum-dependent cell motility
NX80_RS13710	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
NX80_RS13715	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
NX80_RS13720	COG1516	flagellar protein fliS
NX80_RS13745	COG2201	protein-glutamate methylesterase activity
NX80_RS13765	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NX80_RS13770	COG1028	Short-chain dehydrogenase reductase Sdr
NX80_RS13775	COG1028	Short-chain dehydrogenase reductase Sdr
NX80_RS13805	COG1677	Flagellar hook-basal body complex protein FliE
NX80_RS13855	COG3190	flagellar
NX80_RS13875	COG1684	flagellar biosynthetic protein fliR
NX80_RS13880	COG3300	MHYT domain
NX80_RS13880	COG5001	Diguanylate cyclase
NX80_RS13885	COG5001	Diguanylate cyclase
NX80_RS13885	COG3300	MHYT domain
NX80_RS13935	COG0643	Histidine kinase
NX80_RS13935	COG0784	Response regulator, receiver
NX80_RS13935	COG2198	Histidine kinase
NX80_RS14040	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
NX80_RS14045	COG1360	Flagellar Motor Protein
NX80_RS14050	COG1192	Involved in chromosome partitioning
NX80_RS14055	COG0835	chemotaxis
NX80_RS14065	COG0745	RESPONSE REGULATOR receiver
NX80_RS14075	COG0840	transmembrane signaling receptor activity
NX80_RS14080	COG0840	transmembrane signaling receptor activity
NX80_RS14095	COG0840	transmembrane signaling receptor activity
NX80_RS14105	COG0840	transmembrane signaling receptor activity
NX80_RS14110	COG0840	transmembrane signaling receptor activity
NX80_RS14115	COG0840	transmembrane signaling receptor activity
NX80_RS14120	COG0840	transmembrane signaling receptor activity
NX80_RS14125	COG0840	transmembrane signaling receptor activity
NX80_RS14130	COG0840	transmembrane signaling receptor activity
NX80_RS14135	COG0840	transmembrane signaling receptor activity
NX80_RS14140	COG0840	transmembrane signaling receptor activity
NX80_RS14145	COG0840	transmembrane signaling receptor activity
NX80_RS14155	COG0835	chemotaxis
NX80_RS14165	COG0840	transmembrane signaling receptor activity
NX80_RS14180	COG2201	protein-glutamate methylesterase activity
NX80_RS14190	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
NX80_RS14220	COG0318	PFAM AMP-dependent synthetase and ligase
NX80_RS14230	COG3039	Transposase
NX80_RS14245	COG1024	Enoyl-CoA hydratase
NX80_RS14255	COG2205	protein histidine kinase activity
NX80_RS14255	COG0784	Response regulator, receiver
NX80_RS14255	COG2198	Histidine kinase
NX80_RS14265	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
NX80_RS14275	COG3279	Response regulator of the LytR AlgR family
NX80_RS14295	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
NX80_RS14305	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
NX80_RS14310	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
NX80_RS14320	COG0505	Belongs to the CarA family
NX80_RS14325	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
NX80_RS14330	COG2258	MOSC domain
NX80_RS14335	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NX80_RS14380	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
NX80_RS14400	COG0277	FAD linked oxidase domain protein
NX80_RS14405	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NX80_RS14415	COG0531	amino acid
NX80_RS14420	COG0531	amino acid
NX80_RS14425	COG0235	Class ii aldolase
NX80_RS14430	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
NX80_RS14460	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
NX80_RS14460	COG0140	phosphoribosyl-ATP diphosphatase activity
NX80_RS14465	COG0107	imidazoleglycerol-phosphate synthase activity
NX80_RS14470	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
NX80_RS14475	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
NX80_RS14480	COG0131	Imidazoleglycerol-phosphate dehydratase
NX80_RS14480	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
NX80_RS14485	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NX80_RS14490	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
NX80_RS14495	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
NX80_RS14505	COG0124	histidyl-tRNA synthetase
NX80_RS14510	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NX80_RS14520	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
NX80_RS14630	COG1012	belongs to the aldehyde dehydrogenase family
NX80_RS14650	COG0812	UDP-N-acetylmuramate dehydrogenase activity
NX80_RS14655	COG0697	spore germination
NX80_RS14665	COG1794	racemase activity, acting on amino acids and derivatives
NX80_RS14680	COG0671	phosphoesterase, PA-phosphatase related
NX80_RS14685	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
NX80_RS14695	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
NX80_RS14700	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
NX80_RS14725	COG1472	Belongs to the glycosyl hydrolase 3 family
NX80_RS14750	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
NX80_RS14755	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
NX80_RS14760	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
NX80_RS14770	COG0617	tRNA 3'-terminal CCA addition
NX80_RS14785	COG1469	GTP cyclohydrolase I activity
NX80_RS14805	COG0477	Major facilitator Superfamily
NX80_RS14815	COG1070	Carbohydrate kinase
NX80_RS14825	COG1501	Belongs to the glycosyl hydrolase 31 family
NX80_RS14885	COG0800	Aldolase
NX80_RS14890	COG4948	Mandelate Racemase Muconate Lactonizing
NX80_RS14900	COG3734	2-keto-3-deoxy-galactonokinase
NX80_RS14905	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
NX80_RS14915	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NX80_RS14930	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
NX80_RS14935	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
NX80_RS14950	COG0352	thiamine-phosphate diphosphorylase activity
NX80_RS14950	COG0351	phosphomethylpyrimidine kinase
NX80_RS14975	COG0583	DNA-binding transcription factor activity
NX80_RS14980	COG1741	Belongs to the pirin family
NX80_RS15015	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
NX80_RS15020	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
NX80_RS15025	COG2137	regulation of response to DNA damage stimulus
NX80_RS15030	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
NX80_RS15045	COG1546	Belongs to the CinA family
NX80_RS15050	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
NX80_RS15060	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
NX80_RS15065	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
NX80_RS15075	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
NX80_RS15080	COG1534	Rna-binding protein
NX80_RS15085	COG3737	Protein of unknown function (DUF498/DUF598)
NX80_RS15095	COG1238	metal cluster binding
NX80_RS15100	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
NX80_RS15105	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
NX80_RS15110	COG2840	Smr protein MutS2
NX80_RS15120	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
NX80_RS15130	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
NX80_RS15135	COG0148	phosphopyruvate hydratase activity
NX80_RS15155	COG0504	CTP synthase activity
NX80_RS15210	COG3702	type iv secretory pathway
NX80_RS15230	COG2948	multi-organism process
NX80_RS15250	COG3505	Type IV secretory pathway VirD4
NX80_RS15280	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
NX80_RS15295	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
NX80_RS15315	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
NX80_RS15320	COG0174	glutamine synthetase
NX80_RS15375	COG0488	(ABC) transporter
NX80_RS15395	COG4771	TonB-dependent receptor
NX80_RS15415	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
NX80_RS15415	COG4651	solute:proton antiporter activity
NX80_RS15425	COG4772	TonB-dependent receptor
NX80_RS15435	COG4264	IucA IucC family
NX80_RS15440	COG2814	Major facilitator Superfamily
NX80_RS15450	COG0019	diaminopimelate decarboxylase activity
NX80_RS15485	COG4206	TonB-dependent receptor
NX80_RS15505	COG3039	Transposase
NX80_RS15550	COG0542	response to heat
NX80_RS15555	COG1116	anion transmembrane transporter activity
NX80_RS15560	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NX80_RS15565	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
NX80_RS15570	COG0667	Aldo Keto reductase
NX80_RS15575	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NX80_RS15580	COG4771	TonB-dependent receptor
NX80_RS15585	COG2827	Endonuclease containing a URI domain
NX80_RS15635	COG1877	trehalose-phosphatase activity
NX80_RS15655	COG0840	transmembrane signaling receptor activity
NX80_RS15660	COG3011	Protein conserved in bacteria
NX80_RS15675	COG0564	pseudouridine synthase activity
NX80_RS15680	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
NX80_RS15730	COG0314	molybdopterin synthase activity
NX80_RS15735	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
NX80_RS15740	COG0315	cyclic pyranopterin monophosphate synthase activity
NX80_RS15750	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
NX80_RS15755	COG1234	tRNA 3'-trailer cleavage
NX80_RS15760	COG3642	lipopolysaccharide core region biosynthetic process
NX80_RS15765	COG0859	PFAM glycosyl transferase family 9
NX80_RS15780	COG0631	protein serine/threonine phosphatase activity
NX80_RS15790	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
NX80_RS15805	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NX80_RS15815	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NX80_RS15845	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
NX80_RS15855	COG0544	peptidyl-prolyl cis-trans isomerase activity
NX80_RS15900	COG0473	3-isopropylmalate dehydrogenase activity
NX80_RS15920	COG4783	chaperone-mediated protein folding
NX80_RS15935	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
NX80_RS15945	COG0438	transferase activity, transferring glycosyl groups
NX80_RS15950	COG0671	phosphoesterase, PA-phosphatase related
NX80_RS15955	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NX80_RS15965	COG3291	Pkd domain containing protein
NX80_RS15970	COG2833	Protein of unknown function (DUF455)
NX80_RS15990	COG0285	dihydrofolate synthase activity
NX80_RS16000	COG0406	alpha-ribazole phosphatase activity
NX80_RS16030	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
NX80_RS16035	COG4208	sulfate ABC transporter
NX80_RS16040	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
NX80_RS16045	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
NX80_RS16050	COG0156	8-amino-7-oxononanoate synthase activity
NX80_RS16070	COG2885	chlorophyll binding
NX80_RS16075	COG0604	alcohol dehydrogenase
NX80_RS16080	COG1902	pentaerythritol trinitrate reductase activity
NX80_RS16080	COG0446	pyridine nucleotide-disulphide oxidoreductase
NX80_RS16100	COG0625	glutathione transferase activity
NX80_RS16110	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
NX80_RS16140	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
NX80_RS16155	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
NX80_RS16160	COG0203	ribosomal protein L17
NX80_RS16185	COG0201	protein transport
NX80_RS16190	COG0200	Binds to the 23S rRNA
NX80_RS16195	COG1841	ribosomal large subunit assembly
NX80_RS16230	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
NX80_RS16240	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
NX80_RS16245	COG0255	Belongs to the universal ribosomal protein uL29 family
NX80_RS16250	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
NX80_RS16260	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
NX80_RS16270	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
NX80_RS16280	COG0088	Forms part of the polypeptide exit tunnel
NX80_RS16290	COG0051	transcription antitermination factor activity, RNA binding
NX80_RS16310	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
NX80_RS16315	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
NX80_RS16320	COG0049	tRNA binding
NX80_RS16325	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
NX80_RS16330	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
NX80_RS16335	COG0085	RNA polymerase activity
NX80_RS16345	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
NX80_RS16350	COG0081	regulation of translation
NX80_RS16355	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
NX80_RS16360	COG0250	Participates in transcription elongation, termination and antitermination
NX80_RS16365	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
NX80_RS16375	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
NX80_RS16395	COG0012	GTP binding
NX80_RS16400	COG0193	aminoacyl-tRNA hydrolase activity
NX80_RS16405	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
NX80_RS16410	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
NX80_RS16420	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
NX80_RS16425	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
NX80_RS16435	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
NX80_RS16440	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
NX80_RS16450	COG0521	Mo-molybdopterin cofactor biosynthetic process
NX80_RS16470	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NX80_RS16475	COG1295	ribonuclease BN
NX80_RS16500	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
NX80_RS16505	COG1404	Belongs to the peptidase S8 family
NX80_RS16510	COG1404	Belongs to the peptidase S8 family
NX80_RS16515	COG1404	Belongs to the peptidase S8 family
NX80_RS16520	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NX80_RS16540	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
NX80_RS16565	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
NX80_RS16585	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NX80_RS16585	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NX80_RS16630	COG2890	protein-(glutamine-N5) methyltransferase activity
NX80_RS16640	COG3634	alkyl hydroperoxide reductase activity
NX80_RS16645	COG0583	DNA-binding transcription factor activity
NX80_RS16650	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
NX80_RS16655	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
NX80_RS16665	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NX80_RS16675	COG2197	response regulator
NX80_RS16680	COG2205	protein histidine kinase activity
NX80_RS16680	COG5002	protein histidine kinase activity
NX80_RS16680	COG0784	Response regulator, receiver
NX80_RS16700	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NX80_RS16710	COG0697	spore germination
NX80_RS16735	COG3386	PFAM SMP-30 Gluconolaconase
NX80_RS16755	COG1024	Enoyl-CoA hydratase
NX80_RS16765	COG0318	PFAM AMP-dependent synthetase and ligase
NX80_RS16770	COG0583	DNA-binding transcription factor activity
NX80_RS16775	COG3384	dioxygenase
NX80_RS16800	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NX80_RS16805	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NX80_RS16820	COG2096	Adenosyltransferase
NX80_RS16825	COG0123	including yeast histone deacetylase and acetoin utilization protein
NX80_RS16830	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
NX80_RS16840	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
NX80_RS16850	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
NX80_RS16855	COG2967	ApaG domain
NX80_RS16860	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
NX80_RS16875	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
NX80_RS16895	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
NX80_RS16910	COG0642	Histidine kinase
NX80_RS16925	COG4181	ATPase activity
NX80_RS16935	COG2175	clavaminate synthase activity
NX80_RS16945	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
NX80_RS16950	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NX80_RS16970	COG4771	TonB-dependent receptor
NX80_RS16985	COG0667	Aldo Keto reductase
NX80_RS16990	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
NX80_RS17005	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
NX80_RS17010	COG4106	trans-aconitate 2-methyltransferase activity
NX80_RS17020	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
NX80_RS17055	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
NX80_RS17065	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
NX80_RS17070	COG2226	methyltransferase
NX80_RS17120	COG0604	alcohol dehydrogenase
NX80_RS17120	COG3321	synthase
NX80_RS17120	COG1028	Short-chain dehydrogenase reductase Sdr
NX80_RS17130	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
NX80_RS17140	COG0494	nUDIX hydrolase
NX80_RS17145	COG0653	protein targeting
NX80_RS17150	COG0739	heme binding
NX80_RS17160	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
NX80_RS17175	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
NX80_RS17180	COG1181	Belongs to the D-alanine--D-alanine ligase family
NX80_RS17185	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
NX80_RS17190	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
NX80_RS17200	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NX80_RS17205	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
NX80_RS17220	COG3116	cell division
NX80_RS17225	COG0275	rRNA processing
NX80_RS17270	COG0792	nuclease activity
NX80_RS17275	COG1988	membrane-bound metal-dependent
NX80_RS17280	COG0277	FAD linked oxidase domain protein
NX80_RS17285	COG0745	RESPONSE REGULATOR receiver
NX80_RS17290	COG2205	protein histidine kinase activity
NX80_RS17300	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
NX80_RS17305	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
NX80_RS17350	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
NX80_RS17355	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
NX80_RS17360	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
NX80_RS17380	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NX80_RS17380	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NX80_RS17390	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
NX80_RS17395	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
NX80_RS17420	COG0488	(ABC) transporter
NX80_RS17425	COG0242	peptide deformylase activity
NX80_RS17455	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
NX80_RS17505	COG2188	Transcriptional regulator
NX80_RS17515	COG1450	Type ii and iii secretion system protein
NX80_RS17530	COG3166	PFAM Fimbrial assembly family protein
NX80_RS17535	COG3156	type II secretion system protein K
NX80_RS17540	COG4795	General secretion pathway protein
NX80_RS17545	COG2165	general secretion pathway protein
NX80_RS17550	COG4970	Tfp pilus assembly protein FimT
NX80_RS17555	COG2165	general secretion pathway protein
NX80_RS17560	COG1459	type II secretion system
NX80_RS17570	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
NX80_RS17575	COG1404	Belongs to the peptidase S8 family
NX80_RS17585	COG5295	Hep Hag repeat protein
NX80_RS17595	COG0047	phosphoribosylformylglycinamidine synthase activity
NX80_RS17595	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
NX80_RS17605	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
NX80_RS17610	COG4974	Belongs to the 'phage' integrase family
NX80_RS17620	COG0795	lipopolysaccharide-transporting ATPase activity
NX80_RS17630	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
NX80_RS17645	COG0525	valine-tRNA ligase activity
NX80_RS17680	COG3039	Transposase
NX80_RS17715	COG1649	PFAM Uncharacterised BCR, COG1649
NX80_RS17715	COG0726	polysaccharide deacetylase
NX80_RS17720	COG1215	transferase activity, transferring glycosyl groups
NX80_RS17735	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
NX80_RS17740	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
NX80_RS17745	COG1609	Transcriptional regulator
NX80_RS17755	COG2188	Transcriptional regulator
NX80_RS17770	COG3250	beta-galactosidase activity
NX80_RS17800	COG1028	Short-chain dehydrogenase reductase Sdr
NX80_RS17805	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
NX80_RS17810	COG4191	Histidine kinase
NX80_RS17815	COG0784	Response regulator, receiver
NX80_RS17820	COG4251	negative regulation of phosphorylation
NX80_RS17825	COG2823	Periplasmic or secreted lipoprotein
NX80_RS17830	COG0673	inositol 2-dehydrogenase activity
NX80_RS17835	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
NX80_RS17870	COG1051	belongs to the nudix hydrolase family
NX80_RS17870	COG1056	cytidyltransferase-related domain
NX80_RS17885	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
NX80_RS17890	COG0321	lipoyl(octanoyl) transferase activity
NX80_RS17895	COG2921	Belongs to the UPF0250 family
NX80_RS17905	COG1686	Belongs to the peptidase S11 family
NX80_RS17910	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
NX80_RS17915	COG2951	lytic endotransglycosylase activity
NX80_RS17965	COG0772	Belongs to the SEDS family
NX80_RS17980	COG1792	Involved in formation and maintenance of cell shape
NX80_RS17985	COG1077	Cell shape determining protein MreB Mrl
NX80_RS17990	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NX80_RS18010	COG0028	Belongs to the TPP enzyme family
NX80_RS18010	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
NX80_RS18025	COG0367	asparagine synthase
NX80_RS18030	COG1012	belongs to the aldehyde dehydrogenase family
NX80_RS18035	COG0730	response to heat
NX80_RS18070	COG0308	aminopeptidase N
NX80_RS18075	COG5001	Diguanylate cyclase
NX80_RS18075	COG3300	MHYT domain
NX80_RS18085	COG2226	methyltransferase
NX80_RS18110	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
NX80_RS18115	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
NX80_RS18125	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
NX80_RS18135	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
NX80_RS18145	COG2832	Protein of unknown function (DUF454)
NX80_RS18170	COG1505	serine-type exopeptidase activity
NX80_RS18200	COG0181	hydroxymethylbilane synthase activity
NX80_RS18210	COG3275	phosphorelay sensor kinase activity
NX80_RS18220	COG2943	transferase activity, transferring hexosyl groups
NX80_RS18245	COG0659	secondary active sulfate transmembrane transporter activity
NX80_RS18250	COG5297	Belongs to the glycosyl hydrolase family 6
NX80_RS18250	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
NX80_RS18255	COG0840	transmembrane signaling receptor activity
NX80_RS18335	COG1113	amino acid transport
NX80_RS18345	COG4305	rare lipoprotein A
NX80_RS18365	COG0697	spore germination
NX80_RS18435	COG0435	Glutathione S-transferase
NX80_RS18440	COG4221	oxidoreductase activity
NX80_RS18500	COG2176	DNA-directed DNA polymerase activity
NX80_RS18550	COG0546	phosphoglycolate phosphatase activity
NX80_RS18555	COG1802	Transcriptional regulator
NX80_RS18590	COG3052	prosthetic group binding
NX80_RS18630	COG2353	YceI-like domain
NX80_RS18635	COG0778	Nitroreductase
NX80_RS18685	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
NX80_RS18695	COG3386	PFAM SMP-30 Gluconolaconase
NX80_RS18715	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
NX80_RS18720	COG4771	TonB-dependent receptor
NX80_RS18740	COG0459	protein refolding
NX80_RS18755	COG2356	endonuclease I
NX80_RS18765	COG1324	tolerance protein
NX80_RS18775	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
NX80_RS18780	COG0511	ligase activity, forming carbon-carbon bonds
NX80_RS18790	COG0439	Biotin carboxylase
NX80_RS18840	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
NX80_RS18860	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
NX80_RS18865	COG0138	bifunctional purine biosynthesis protein purh
NX80_RS18870	COG0419	ATPase involved in DNA repair
NX80_RS18880	COG0151	Belongs to the GarS family
NX80_RS18885	COG1289	transmembrane transporter activity
NX80_RS18890	COG2814	Major facilitator Superfamily
NX80_RS18900	COG2814	Major facilitator Superfamily
NX80_RS18920	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
NX80_RS18935	COG0316	Belongs to the HesB IscA family
NX80_RS18955	COG0745	RESPONSE REGULATOR receiver
NX80_RS18990	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
NX80_RS19000	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
NX80_RS19010	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
NX80_RS19015	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NX80_RS19025	COG0134	indole-3-glycerol-phosphate synthase activity
NX80_RS19030	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
NX80_RS19060	COG1597	lipid kinase activity
NX80_RS19065	COG0456	acetyltransferase
NX80_RS19070	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
NX80_RS19080	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
NX80_RS19085	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
NX80_RS19125	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
NX80_RS19130	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NX80_RS19135	COG1136	(ABC) transporter
NX80_RS19140	COG0577	efflux transmembrane transporter activity
NX80_RS19145	COG0577	efflux transmembrane transporter activity
NX80_RS19150	COG3039	Transposase
NX80_RS19165	COG4191	Histidine kinase
NX80_RS19200	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
NX80_RS19205	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
NX80_RS19210	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
NX80_RS19215	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
NX80_RS19230	COG0356	it plays a direct role in the translocation of protons across the membrane
NX80_RS19250	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NX80_RS19260	COG0508	dehydrogenase complex catalyzes the overall conversion of
NX80_RS19305	COG2011	ABC-type metal ion transport system permease component
NX80_RS19310	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
NX80_RS19315	COG0697	spore germination
NX80_RS19320	COG1666	GTP binding
NX80_RS19330	COG5002	protein histidine kinase activity
NX80_RS19330	COG0784	Response regulator, receiver
NX80_RS19330	COG2198	Histidine kinase
NX80_RS19350	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NX80_RS19355	COG1187	pseudouridine synthase activity
NX80_RS19360	COG2813	Specifically methylates the guanine in position
NX80_RS19390	COG2202	Pas domain
NX80_RS19390	COG2205	protein histidine kinase activity
NX80_RS19410	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
NX80_RS19415	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NX80_RS19460	COG0745	RESPONSE REGULATOR receiver
NX80_RS19475	COG1404	Belongs to the peptidase S8 family
NX80_RS19500	COG0842	Transport permease protein
NX80_RS19505	COG1131	(ABC) transporter
NX80_RS19510	COG0025	NhaP-type Na H and K H
NX80_RS19520	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
NX80_RS19525	COG1573	uracil-dna glycosylase
NX80_RS19540	COG3384	dioxygenase
NX80_RS19550	COG0583	DNA-binding transcription factor activity
NX80_RS19560	COG0667	Aldo Keto reductase
NX80_RS19570	COG3590	peptidase
NX80_RS19585	COG0531	amino acid
NX80_RS19600	COG2972	Histidine kinase
NX80_RS19625	COG3685	Protein conserved in bacteria
NX80_RS19630	COG3546	catalase activity
NX80_RS19680	COG1271	oxidase subunit
NX80_RS19685	COG1294	oxidase, subunit
NX80_RS19700	COG1028	Short-chain dehydrogenase reductase Sdr
NX80_RS19710	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
NX80_RS19730	COG1132	(ABC) transporter
NX80_RS19745	COG1063	alcohol dehydrogenase
NX80_RS19800	COG1131	(ABC) transporter
NX80_RS19830	COG0038	chloride channel
NX80_RS19840	COG0024	Methionine aminopeptidase
NX80_RS19960	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NX80_RS19965	COG1490	D-aminoacyl-tRNA deacylase activity
NX80_RS19970	COG1560	Kdo2-lipid A biosynthetic process
NX80_RS20015	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
NX80_RS20015	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
NX80_RS20020	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
NX80_RS20025	COG0242	peptide deformylase activity
NX80_RS20030	COG1652	LysM domain
NX80_RS20035	COG0758	DNA mediated transformation
NX80_RS20055	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
NX80_RS20055	COG1754	DNA topoisomerase type I activity
NX80_RS20060	COG0009	L-threonylcarbamoyladenylate synthase
NX80_RS20075	COG1028	Short-chain dehydrogenase reductase Sdr
NX80_RS20085	COG0616	signal peptide processing
NX80_RS20090	COG0534	Mate efflux family protein
NX80_RS20110	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
NX80_RS20115	COG0625	glutathione transferase activity
NX80_RS20130	COG1252	NADH dehydrogenase
NX80_RS20135	COG2860	membrane
NX80_RS20140	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NX80_RS20145	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
NX80_RS20150	COG3437	response regulator, receiver
NX80_RS20155	COG2177	Part of the ABC transporter FtsEX involved in
NX80_RS20160	COG2884	Cell division ATP-binding protein ftsE
NX80_RS20170	COG3118	belongs to the thioredoxin family
NX80_RS20175	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
NX80_RS20185	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
NX80_RS20235	COG1518	maintenance of DNA repeat elements
NX80_RS20240	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
NX80_RS20260	COG1652	LysM domain
NX80_RS20265	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
NX80_RS20265	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
NX80_RS20270	COG1473	amidohydrolase
NX80_RS20280	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NX80_RS20300	COG5383	Protein conserved in bacteria
NX80_RS20340	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
NX80_RS20345	COG3023	N-Acetylmuramoyl-L-alanine amidase
NX80_RS20355	COG4948	Mandelate Racemase Muconate Lactonizing
NX80_RS20365	COG0531	amino acid
NX80_RS20380	COG4682	membrane
NX80_RS20385	COG2133	pyrroloquinoline quinone binding
NX80_RS20395	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
NX80_RS20400	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
NX80_RS20410	COG1610	YqeY-like protein
NX80_RS20415	COG1295	ribonuclease BN
NX80_RS20420	COG0358	DNA primase activity
NX80_RS20465	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
NX80_RS20480	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
NX80_RS20505	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
NX80_RS20540	COG0739	heme binding
NX80_RS20555	COG2211	Major facilitator Superfamily
NX80_RS20560	COG0708	Exodeoxyribonuclease III
NX80_RS20575	COG1192	Involved in chromosome partitioning
NX80_RS20580	COG1475	DNA binding
NX80_RS20595	COG0463	Glycosyl transferase, family 2
NX80_RS20620	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
NX80_RS20630	COG0018	arginyl-trna synthetase
NX80_RS20645	COG4221	oxidoreductase activity
NX80_RS20665	COG1166	arginine decarboxylase activity
NX80_RS20670	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
NX80_RS20700	COG3525	Glycosyl hydrolase, family 20, catalytic domain
NX80_RS20700	COG3291	Pkd domain containing protein
NX80_RS20715	COG0606	chelatase, subunit chli
NX80_RS20730	COG4943	cyclic-guanylate-specific phosphodiesterase activity
NX80_RS20760	COG1690	Belongs to the RtcB family
NX80_RS20795	COG1090	epimerase
NX80_RS20805	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NX80_RS20825	COG0628	permease
NX80_RS20830	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NX80_RS20835	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
NX80_RS20845	COG1595	DNA-templated transcription, initiation
NX80_RS20850	COG0753	catalase activity
NX80_RS20865	COG2197	response regulator
NX80_RS20870	COG4585	Histidine kinase
NX80_RS20875	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NX80_RS20880	COG1136	(ABC) transporter
NX80_RS20905	COG0697	spore germination
NX80_RS20930	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NX80_RS20935	COG0180	Tryptophanyl-tRNA synthetase
NX80_RS20940	COG3237	CsbD-like
NX80_RS21000	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
NX80_RS21015	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
NX80_RS21020	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
NX80_RS21020	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
NX80_RS21035	COG3228	Belongs to the MtfA family
NX80_RS21050	COG2205	protein histidine kinase activity
NX80_RS21055	COG0745	RESPONSE REGULATOR receiver
NX80_RS21065	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
NX80_RS21100	COG1199	ATP-dependent helicase activity
NX80_RS21115	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
NX80_RS21190	COG0625	glutathione transferase activity
NX80_RS21225	COG4555	ABC transporter
NX80_RS21240	COG1476	TRANSCRIPTIONal
NX80_RS21255	COG1230	cation diffusion facilitator family transporter
NX80_RS21260	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
NX80_RS21265	COG1131	(ABC) transporter
NX80_RS21270	COG0842	Transport permease protein
NX80_RS21280	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
NX80_RS21305	COG1607	acyl-coa hydrolase
NX80_RS21310	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NX80_RS21325	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NX80_RS21335	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NX80_RS21350	COG0045	succinate-CoA ligase (ADP-forming) activity
NX80_RS21350	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NX80_RS21350	COG1042	CoA-binding domain protein
NX80_RS21360	COG2239	Acts as a magnesium transporter
NX80_RS21380	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
NX80_RS21385	COG3387	PFAM Glycoside hydrolase 15-related
NX80_RS21400	COG3100	YcgL domain-containing protein
NX80_RS21405	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NX80_RS21415	COG0463	Glycosyl transferase, family 2
NX80_RS21430	COG1028	Short-chain dehydrogenase reductase Sdr
NX80_RS21455	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
NX80_RS21470	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NX80_RS21515	COG0408	coproporphyrinogen oxidase activity
NX80_RS21615	COG0210	DNA helicase
NX80_RS21635	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NX80_RS21645	COG2159	amidohydrolase
NX80_RS21670	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NX80_RS21695	COG0357	Ribosomal RNA small subunit methyltransferase G
NX80_RS21710	COG2091	lysine biosynthetic process via aminoadipic acid
NX80_RS21725	COG0708	Exodeoxyribonuclease III
NX80_RS21730	COG1940	carbohydrate kinase activity
NX80_RS21740	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NX80_RS21750	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NX80_RS21755	COG3162	membrane
NX80_RS21815	COG1028	Short-chain dehydrogenase reductase Sdr
NX80_RS21820	COG0179	Fumarylacetoacetate (FAA) hydrolase
NX80_RS21825	COG4948	Mandelate Racemase Muconate Lactonizing
NX80_RS21830	COG3254	rhamnose metabolic process
NX80_RS21835	COG0738	Major facilitator superfamily
NX80_RS21840	COG1414	Transcriptional regulator
NX80_RS21855	COG2205	protein histidine kinase activity
NX80_RS21865	COG3459	Glycosyltransferase 36 associated
NX80_RS21870	COG2211	Major facilitator Superfamily
NX80_RS21875	COG3265	gluconokinase activity
NX80_RS21915	COG2911	Protein conserved in bacteria
NX80_RS21920	COG0729	surface antigen
NX80_RS21955	COG4771	TonB-dependent receptor
NX80_RS21960	COG0457	Tetratricopeptide repeat
NX80_RS21970	COG0752	glycyl-tRNA synthetase alpha subunit
NX80_RS21975	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
NX80_RS21990	COG0519	Catalyzes the synthesis of GMP from XMP
NX80_RS21990	COG0518	GMP synthase (glutamine-hydrolyzing) activity
NX80_RS22000	COG0805	protein transport
NX80_RS22005	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NX80_RS22010	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NX80_RS22020	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
NX80_RS22040	COG2974	May be involved in recombination
NX80_RS22045	COG0037	tRNA processing
NX80_RS22065	COG3661	Belongs to the glycosyl hydrolase 67 family
NX80_RS22075	COG4948	Mandelate Racemase Muconate Lactonizing
NX80_RS22085	COG1472	Belongs to the glycosyl hydrolase 3 family
NX80_RS22090	COG0246	Mannitol dehydrogenase
NX80_RS22195	COG1904	glucuronate isomerase
NX80_RS22200	COG3693	PFAM glycoside hydrolase, family 10
NX80_RS22220	COG2211	Major facilitator Superfamily
NX80_RS22260	COG2937	Belongs to the GPAT DAPAT family
NX80_RS22290	COG0284	orotidine-5'-phosphate decarboxylase activity
NX80_RS22295	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
NX80_RS22300	COG3132	Protein of unknown function, DUF480
NX80_RS22315	COG0210	DNA helicase
NX80_RS22320	COG1435	thymidine kinase activity
NX80_RS22330	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
NX80_RS22395	COG0676	glucose-6-phosphate 1-epimerase activity
NX80_RS22405	COG3012	SEC-C Motif Domain Protein
NX80_RS22410	COG0730	response to heat
NX80_RS22430	COG0302	gtp cyclohydrolase
NX80_RS22445	COG1566	PFAM secretion protein HlyD family protein
NX80_RS22455	COG1289	transmembrane transporter activity
NX80_RS22460	COG0477	Major facilitator Superfamily
NX80_RS22470	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NX80_RS22515	COG0564	pseudouridine synthase activity
NX80_RS22590	COG1074	ATP-dependent DNA helicase activity
NX80_RS22595	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
NX80_RS22630	COG1127	ABC transporter
NX80_RS22635	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
NX80_RS22640	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
NX80_RS22655	COG2853	Lipoprotein
NX80_RS22670	COG0386	Belongs to the glutathione peroxidase family
NX80_RS22680	COG1322	Protein conserved in bacteria
NX80_RS22685	COG0604	alcohol dehydrogenase
NX80_RS22720	COG0531	amino acid
NX80_RS22745	COG3835	regulator
NX80_RS22750	COG1929	Belongs to the glycerate kinase type-1 family
NX80_RS22755	COG2271	Major facilitator Superfamily
NX80_RS22775	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
NX80_RS22785	COG0861	Integral membrane protein TerC family
NX80_RS22795	COG0584	glycerophosphoryl diester phosphodiesterase
NX80_RS22810	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
NX80_RS22820	COG0706	membrane insertase activity
NX80_RS22890	COG4691	Plasmid stability protein
NX80_RS22915	COG1192	Involved in chromosome partitioning
NX80_RS22990	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs