locus-tag	class	description
BI313_RS00330	COG0557	exoribonuclease II activity
BI313_RS00340	COG0557	exoribonuclease II activity
BI313_RS00610	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BI313_RS00735	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
BI313_RS00890	COG2189	Belongs to the N(4) N(6)-methyltransferase family
BI313_RS01205	COG0567	Dehydrogenase, E1 component
BI313_RS01230	COG2850	peptidyl-arginine hydroxylation
BI313_RS01310	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BI313_RS01320	COG2914	Belongs to the UPF0125 (RnfH) family
BI313_RS01325	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BI313_RS01335	COG0497	DNA recombination
BI313_RS01340	COG1420	regulation of RNA biosynthetic process
BI313_RS01345	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BI313_RS01360	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
BI313_RS01390	COG0583	DNA-binding transcription factor activity
BI313_RS01395	COG1132	(ABC) transporter
BI313_RS01420	COG0567	Dehydrogenase, E1 component
BI313_RS01430	COG2850	peptidyl-arginine hydroxylation
BI313_RS01445	COG1253	flavin adenine dinucleotide binding
BI313_RS01475	COG1131	(ABC) transporter
BI313_RS01480	COG1725	Transcriptional regulator
BI313_RS01490	COG0386	Belongs to the glutathione peroxidase family
BI313_RS01500	COG2900	Belongs to the SlyX family
BI313_RS01510	COG2755	lipolytic protein G-D-S-L family
BI313_RS01510	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
BI313_RS01535	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BI313_RS01545	COG1410	methionine synthase
BI313_RS01545	COG0646	methionine synthase
BI313_RS01550	COG0646	methionine synthase
BI313_RS01550	COG1410	methionine synthase
BI313_RS01555	COG2226	methyltransferase
BI313_RS01560	COG1960	acyl-CoA dehydrogenase activity
BI313_RS01575	COG0557	exoribonuclease II activity
BI313_RS01585	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BI313_RS01595	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BI313_RS01605	COG0704	Plays a role in the regulation of phosphate uptake
BI313_RS01615	COG0581	inorganic phosphate transmembrane transporter activity
BI313_RS01620	COG0573	inorganic phosphate transmembrane transporter activity
BI313_RS01625	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BI313_RS01650	COG0659	secondary active sulfate transmembrane transporter activity
BI313_RS01655	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BI313_RS01665	COG1024	Enoyl-CoA hydratase
BI313_RS01675	COG0494	nUDIX hydrolase
BI313_RS01710	COG2264	protein methyltransferase activity
BI313_RS01720	COG0488	(ABC) transporter
BI313_RS01760	COG2925	Exonuclease
BI313_RS01765	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BI313_RS01770	COG3844	kynureninase activity
BI313_RS01785	COG0288	reversible hydration of carbon dioxide
BI313_RS01810	COG0017	Asparaginyl-tRNA synthetase
BI313_RS01815	COG0316	Belongs to the HesB IscA family
BI313_RS01820	COG0360	Binds together with S18 to 16S ribosomal RNA
BI313_RS01840	COG3115	cell septum assembly
BI313_RS01850	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BI313_RS01855	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BI313_RS01885	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
BI313_RS01895	COG4993	Dehydrogenase
BI313_RS01910	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
BI313_RS01920	COG2986	histidine ammonia-lyase
BI313_RS01925	COG1228	amidohydrolase
BI313_RS01960	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
BI313_RS01965	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
BI313_RS01970	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
BI313_RS01975	COG1605	Chorismate mutase
BI313_RS01975	COG0077	Prephenate dehydratase
BI313_RS01980	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BI313_RS01995	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BI313_RS02000	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
BI313_RS02005	COG0583	DNA-binding transcription factor activity
BI313_RS02045	COG1122	ATPase activity
BI313_RS02075	COG2003	Belongs to the UPF0758 family
BI313_RS02110	COG2189	Belongs to the N(4) N(6)-methyltransferase family
BI313_RS02250	COG0840	transmembrane signaling receptor activity
BI313_RS02265	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
BI313_RS02270	COG4191	Histidine kinase
BI313_RS02270	COG0784	Response regulator, receiver
BI313_RS02285	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BI313_RS02295	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
BI313_RS02305	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BI313_RS02320	COG1595	DNA-templated transcription, initiation
BI313_RS02360	COG2244	polysaccharide biosynthetic process
BI313_RS02395	COG4106	trans-aconitate 2-methyltransferase activity
BI313_RS02405	COG0438	transferase activity, transferring glycosyl groups
BI313_RS02425	COG1132	(ABC) transporter
BI313_RS02430	COG0477	Major facilitator Superfamily
BI313_RS02435	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BI313_RS02450	COG1253	flavin adenine dinucleotide binding
BI313_RS02470	COG1434	Gram-negative-bacterium-type cell wall biogenesis
BI313_RS02480	COG2134	cdp-diacylglycerol pyrophosphatase
BI313_RS02495	COG0504	CTP synthase activity
BI313_RS02510	COG0148	phosphopyruvate hydratase activity
BI313_RS02515	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
BI313_RS02525	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
BI313_RS02530	COG0585	pseudouridine synthase activity
BI313_RS02535	COG2840	Smr protein MutS2
BI313_RS02540	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
BI313_RS02545	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BI313_RS02550	COG1238	metal cluster binding
BI313_RS02560	COG3737	Protein of unknown function (DUF498/DUF598)
BI313_RS02565	COG1534	Rna-binding protein
BI313_RS02570	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
BI313_RS02575	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BI313_RS02580	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BI313_RS02585	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BI313_RS02595	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BI313_RS02600	COG1546	Belongs to the CinA family
BI313_RS02605	COG4771	TonB-dependent receptor
BI313_RS02610	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BI313_RS02615	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BI313_RS02620	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BI313_RS02625	COG2137	regulation of response to DNA damage stimulus
BI313_RS02630	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BI313_RS02635	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
BI313_RS02650	COG1741	Belongs to the pirin family
BI313_RS02655	COG0583	DNA-binding transcription factor activity
BI313_RS02680	COG0352	thiamine-phosphate diphosphorylase activity
BI313_RS02680	COG0351	phosphomethylpyrimidine kinase
BI313_RS02695	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
BI313_RS02700	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BI313_RS02715	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BI313_RS02725	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
BI313_RS02730	COG3734	2-keto-3-deoxy-galactonokinase
BI313_RS02740	COG4948	Mandelate Racemase Muconate Lactonizing
BI313_RS02745	COG0800	Aldolase
BI313_RS02785	COG1501	Belongs to the glycosyl hydrolase 31 family
BI313_RS02795	COG1070	Carbohydrate kinase
BI313_RS02800	COG2115	Belongs to the xylose isomerase family
BI313_RS02805	COG0477	Major facilitator Superfamily
BI313_RS02825	COG0860	N-Acetylmuramoyl-L-alanine amidase
BI313_RS02840	COG0617	tRNA 3'-terminal CCA addition
BI313_RS02855	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
BI313_RS02860	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
BI313_RS02895	COG1472	Belongs to the glycosyl hydrolase 3 family
BI313_RS02910	COG5001	Diguanylate cyclase
BI313_RS02910	COG4251	negative regulation of phosphorylation
BI313_RS02910	COG3706	GGDEF domain
BI313_RS02910	COG2203	Gaf domain
BI313_RS02920	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
BI313_RS02930	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
BI313_RS02935	COG0671	phosphoesterase, PA-phosphatase related
BI313_RS02945	COG1794	racemase activity, acting on amino acids and derivatives
BI313_RS02950	COG0697	spore germination
BI313_RS02955	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BI313_RS02975	COG1012	belongs to the aldehyde dehydrogenase family
BI313_RS03015	COG2003	Belongs to the UPF0758 family
BI313_RS03020	COG0688	phosphatidylethanolamine metabolic process
BI313_RS03035	COG3220	belongs to the UPF0276 family
BI313_RS03125	COG0840	transmembrane signaling receptor activity
BI313_RS03130	COG0840	transmembrane signaling receptor activity
BI313_RS03140	COG1215	transferase activity, transferring glycosyl groups
BI313_RS03145	COG0726	polysaccharide deacetylase
BI313_RS03145	COG1649	PFAM Uncharacterised BCR, COG1649
BI313_RS03235	COG2801	Transposase and inactivated derivatives
BI313_RS03240	COG2963	transposase activity
BI313_RS03270	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
BI313_RS03280	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BI313_RS03285	COG0124	histidyl-tRNA synthetase
BI313_RS03300	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
BI313_RS03305	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BI313_RS03310	COG0131	Imidazoleglycerol-phosphate dehydratase
BI313_RS03310	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
BI313_RS03315	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
BI313_RS03320	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
BI313_RS03325	COG0107	imidazoleglycerol-phosphate synthase activity
BI313_RS03330	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BI313_RS03330	COG0140	phosphoribosyl-ATP diphosphatase activity
BI313_RS03350	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
BI313_RS03355	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
BI313_RS03370	COG0531	amino acid
BI313_RS03375	COG0531	amino acid
BI313_RS03385	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BI313_RS03390	COG0277	FAD linked oxidase domain protein
BI313_RS03410	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BI313_RS03430	COG1024	Enoyl-CoA hydratase
BI313_RS03455	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BI313_RS03460	COG2258	MOSC domain
BI313_RS03470	COG0505	Belongs to the CarA family
BI313_RS03480	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BI313_RS03485	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BI313_RS03495	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BI313_RS03510	COG3279	Response regulator of the LytR AlgR family
BI313_RS03515	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
BI313_RS03520	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BI313_RS03530	COG2198	Histidine kinase
BI313_RS03530	COG2205	protein histidine kinase activity
BI313_RS03530	COG0784	Response regulator, receiver
BI313_RS03535	COG2198	Histidine kinase
BI313_RS03535	COG0784	Response regulator, receiver
BI313_RS03535	COG2205	protein histidine kinase activity
BI313_RS03540	COG1024	Enoyl-CoA hydratase
BI313_RS03545	COG0318	PFAM AMP-dependent synthetase and ligase
BI313_RS03575	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BI313_RS03600	COG0840	transmembrane signaling receptor activity
BI313_RS03610	COG0835	chemotaxis
BI313_RS03625	COG0840	transmembrane signaling receptor activity
BI313_RS03635	COG0840	transmembrane signaling receptor activity
BI313_RS03640	COG0840	transmembrane signaling receptor activity
BI313_RS03645	COG0840	transmembrane signaling receptor activity
BI313_RS03665	COG0840	transmembrane signaling receptor activity
BI313_RS03680	COG0643	Histidine kinase
BI313_RS03680	COG2198	Histidine kinase
BI313_RS03685	COG0745	RESPONSE REGULATOR receiver
BI313_RS03695	COG0835	chemotaxis
BI313_RS03700	COG1192	Involved in chromosome partitioning
BI313_RS03710	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
BI313_RS03790	COG2198	Histidine kinase
BI313_RS03790	COG0643	Histidine kinase
BI313_RS03790	COG0784	Response regulator, receiver
BI313_RS03835	COG5001	Diguanylate cyclase
BI313_RS03835	COG3300	MHYT domain
BI313_RS03905	COG1677	Flagellar hook-basal body complex protein FliE
BI313_RS03960	COG1028	Short-chain dehydrogenase reductase Sdr
BI313_RS03985	COG2201	protein-glutamate methylesterase activity
BI313_RS04015	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
BI313_RS04020	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BI313_RS04025	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BI313_RS04035	COG3951	Flagellar rod assembly protein muramidase FlgJ
BI313_RS04035	COG1705	Flagellar rod assembly protein muramidase FlgJ
BI313_RS04065	COG4787	bacterial-type flagellum-dependent cell motility
BI313_RS04075	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
BI313_RS04080	COG1558	bacterial-type flagellum-dependent cell motility
BI313_RS04085	COG1815	bacterial-type flagellum-dependent cell motility
BI313_RS04090	COG0784	Response regulator, receiver
BI313_RS04090	COG0835	chemotaxis
BI313_RS04110	COG4191	Histidine kinase
BI313_RS04150	COG0482	sulfurtransferase activity
BI313_RS04165	COG0542	response to heat
BI313_RS04190	COG0492	ferredoxin-NADP+ reductase activity
BI313_RS04195	COG1674	ftsk spoiiie
BI313_RS04210	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BI313_RS04215	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BI313_RS04220	COG0183	Belongs to the thiolase family
BI313_RS04225	COG1250	3-hydroxyacyl-CoA dehydrogenase
BI313_RS04225	COG1024	Enoyl-CoA hydratase
BI313_RS04250	COG1426	Protein conserved in bacteria
BI313_RS04260	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BI313_RS04265	COG1160	GTP binding
BI313_RS04275	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BI313_RS04290	COG0708	Exodeoxyribonuclease III
BI313_RS04305	COG0746	molybdenum cofactor guanylyltransferase activity
BI313_RS04315	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BI313_RS04315	COG1648	precorrin-2 dehydrogenase activity
BI313_RS04325	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BI313_RS04335	COG2223	nitrite transmembrane transporter activity
BI313_RS04340	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BI313_RS04345	COG2146	nitrite reductase [NAD(P)H] activity
BI313_RS04350	COG0243	molybdopterin cofactor binding
BI313_RS04365	COG3685	Protein conserved in bacteria
BI313_RS04375	COG5001	Diguanylate cyclase
BI313_RS04445	COG1238	metal cluster binding
BI313_RS04455	COG3226	Transcriptional regulator
BI313_RS04465	COG2223	nitrite transmembrane transporter activity
BI313_RS04470	COG4221	oxidoreductase activity
BI313_RS04495	COG0363	glucosamine-6-phosphate deaminase activity
BI313_RS04515	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
BI313_RS04520	COG1028	Short-chain dehydrogenase reductase Sdr
BI313_RS04535	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BI313_RS04545	COG1028	Short-chain dehydrogenase reductase Sdr
BI313_RS04550	COG0583	DNA-binding transcription factor activity
BI313_RS04565	COG2369	cell adhesion
BI313_RS04630	COG5599	Phosphatase
BI313_RS04665	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BI313_RS04775	COG2154	pterin-4-alpha-carbinolamine dehydratase
BI313_RS04785	COG0428	transporter
BI313_RS04800	COG1530	ribonuclease E activity
BI313_RS04810	COG1054	Belongs to the UPF0176 family
BI313_RS04830	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
BI313_RS04860	COG0322	excinuclease ABC activity
BI313_RS04870	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BI313_RS04875	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
BI313_RS04880	COG1663	tetraacyldisaccharide 4'-kinase activity
BI313_RS04885	COG1132	(ABC) transporter
BI313_RS04895	COG0811	peptide transport
BI313_RS04920	COG4591	ABC-type transport system involved in lipoprotein release permease component
BI313_RS04930	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
BI313_RS04935	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BI313_RS04950	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
BI313_RS04965	COG0354	folic acid binding
BI313_RS04975	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BI313_RS04980	COG0837	glucose binding
BI313_RS04985	COG0363	glucosamine-6-phosphate deaminase activity
BI313_RS04990	COG0129	dihydroxy-acid dehydratase activity
BI313_RS04995	COG0800	Aldolase
BI313_RS05060	COG2205	protein histidine kinase activity
BI313_RS05060	COG5002	protein histidine kinase activity
BI313_RS05060	COG0784	Response regulator, receiver
BI313_RS05065	COG2183	response to ionizing radiation
BI313_RS05090	COG3243	poly(R)-hydroxyalkanoic acid synthase
BI313_RS05100	COG1183	phosphatidylcholine synthase activity
BI313_RS05105	COG1028	Short-chain dehydrogenase reductase Sdr
BI313_RS05130	COG0668	transmembrane transport
BI313_RS05135	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
BI313_RS05150	COG1914	H( )-stimulated, divalent metal cation uptake system
BI313_RS05175	COG2814	Major facilitator Superfamily
BI313_RS05190	COG1335	isochorismatase
BI313_RS05200	COG4585	Histidine kinase
BI313_RS05205	COG2197	response regulator
BI313_RS05230	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BI313_RS05245	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BI313_RS05245	COG0475	glutathione-regulated potassium exporter activity
BI313_RS05250	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BI313_RS05260	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BI313_RS05265	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
BI313_RS05275	COG0776	regulation of translation
BI313_RS05285	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BI313_RS05300	COG2957	Belongs to the agmatine deiminase family
BI313_RS05305	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BI313_RS05330	COG0395	ABC-type sugar transport system, permease component
BI313_RS05335	COG1175	transmembrane transport
BI313_RS05340	COG1653	transport
BI313_RS05365	COG2350	Protein conserved in bacteria
BI313_RS05370	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
BI313_RS05375	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BI313_RS05380	COG1187	pseudouridine synthase activity
BI313_RS05395	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BI313_RS05405	COG0436	Aminotransferase
BI313_RS05410	COG4133	protoheme IX ABC transporter activity
BI313_RS05465	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BI313_RS05475	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
BI313_RS05480	COG4988	ABC transporter
BI313_RS05490	COG1294	oxidase, subunit
BI313_RS05515	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
BI313_RS05535	COG0165	Argininosuccinate lyase
BI313_RS05550	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BI313_RS05555	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BI313_RS05565	COG0137	argininosuccinate synthase activity
BI313_RS05575	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BI313_RS05585	COG0215	cysteine-tRNA ligase activity
BI313_RS05590	COG2166	iron-sulfur cluster assembly
BI313_RS05610	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BI313_RS05630	COG4302	ethanolamine ammonia-lyase activity
BI313_RS05650	COG4677	pectinesterase activity
BI313_RS05670	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BI313_RS05675	COG0402	S-adenosylhomocysteine deaminase activity
BI313_RS05690	COG1509	lysine 2,3-aminomutase activity
BI313_RS05695	COG3300	MHYT domain
BI313_RS05695	COG5001	Diguanylate cyclase
BI313_RS05710	COG0483	inositol monophosphate 1-phosphatase activity
BI313_RS05715	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BI313_RS05730	COG0488	(ABC) transporter
BI313_RS05735	COG0513	Belongs to the DEAD box helicase family
BI313_RS05745	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BI313_RS05750	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
BI313_RS05760	COG0625	glutathione transferase activity
BI313_RS05770	COG1671	Belongs to the UPF0178 family
BI313_RS05775	COG4681	YaeQ
BI313_RS05780	COG2081	HI0933 family
BI313_RS05790	COG0501	Belongs to the peptidase M48B family
BI313_RS05795	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BI313_RS05800	COG1028	Short-chain dehydrogenase reductase Sdr
BI313_RS05820	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BI313_RS05825	COG0860	N-Acetylmuramoyl-L-alanine amidase
BI313_RS05835	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
BI313_RS05835	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BI313_RS05840	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BI313_RS05855	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BI313_RS05890	COG0582	viral genome integration into host DNA
BI313_RS05935	COG0835	chemotaxis
BI313_RS05940	COG0840	transmembrane signaling receptor activity
BI313_RS05950	COG1201	RNA secondary structure unwinding
BI313_RS05965	COG2969	positive regulation of protein catabolic process
BI313_RS05970	COG0625	glutathione transferase activity
BI313_RS05975	COG2857	Cytochrome c1
BI313_RS05985	COG0723	plastoquinol--plastocyanin reductase activity
BI313_RS05990	COG0741	lytic transglycosylase activity
BI313_RS06010	COG1702	phosphate starvation-inducible protein PhoH
BI313_RS06020	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
BI313_RS06030	COG4535	Mg2 and Co2 transporter CorC
BI313_RS06045	COG1012	belongs to the aldehyde dehydrogenase family
BI313_RS06055	COG1177	transmembrane transport
BI313_RS06060	COG1176	ABC-type spermidine putrescine transport system, permease component I
BI313_RS06065	COG3842	ATPase activity
BI313_RS06085	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
BI313_RS06105	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
BI313_RS06110	COG0174	glutamine synthetase
BI313_RS06115	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BI313_RS06130	COG2703	oxygen carrier activity
BI313_RS06135	COG0477	Major facilitator Superfamily
BI313_RS06150	COG0243	molybdopterin cofactor binding
BI313_RS06155	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
BI313_RS06160	COG2223	nitrite transmembrane transporter activity
BI313_RS06165	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BI313_RS06175	COG2733	membrane
BI313_RS06180	COG0784	Response regulator, receiver
BI313_RS06180	COG2205	protein histidine kinase activity
BI313_RS06180	COG5002	protein histidine kinase activity
BI313_RS06190	COG0477	Major facilitator Superfamily
BI313_RS06205	COG2902	Dehydrogenase
BI313_RS06215	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BI313_RS06220	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BI313_RS06235	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
BI313_RS06235	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BI313_RS06240	COG1105	Belongs to the carbohydrate kinase PfkB family
BI313_RS06245	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BI313_RS06245	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BI313_RS06260	COG2963	transposase activity
BI313_RS06265	COG2801	Transposase and inactivated derivatives
BI313_RS06290	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BI313_RS06300	COG1862	Preprotein translocase
BI313_RS06305	COG0343	queuine tRNA-ribosyltransferase activity
BI313_RS06310	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
BI313_RS06355	COG3291	Pkd domain containing protein
BI313_RS06360	COG0405	Gamma-glutamyltransferase
BI313_RS06365	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
BI313_RS06380	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BI313_RS06385	COG0742	ribosomal rna small subunit methyltransferase
BI313_RS06410	COG4206	TonB-dependent receptor
BI313_RS06440	COG0531	amino acid
BI313_RS06460	COG0006	proline dipeptidase activity
BI313_RS06470	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BI313_RS06485	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BI313_RS06490	COG3938	Belongs to the proline racemase family
BI313_RS06500	COG0552	protein localization to endoplasmic reticulum
BI313_RS06520	COG4191	Histidine kinase
BI313_RS06520	COG0784	Response regulator, receiver
BI313_RS06565	COG1960	acyl-CoA dehydrogenase activity
BI313_RS06575	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BI313_RS06595	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BI313_RS06605	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BI313_RS06635	COG0438	transferase activity, transferring glycosyl groups
BI313_RS06645	COG0438	transferase activity, transferring glycosyl groups
BI313_RS06650	COG0438	transferase activity, transferring glycosyl groups
BI313_RS06700	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BI313_RS06700	COG0072	phenylalanine-tRNA ligase activity
BI313_RS06705	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BI313_RS06720	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BI313_RS06725	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BI313_RS06750	COG1082	Xylose isomerase domain protein TIM barrel
BI313_RS06765	COG0366	Alpha amylase catalytic
BI313_RS06775	COG3702	type iv secretory pathway
BI313_RS06795	COG2948	multi-organism process
BI313_RS06815	COG3505	Type IV secretory pathway VirD4
BI313_RS06830	COG0556	nucleotide-excision repair
BI313_RS06875	COG1611	Belongs to the LOG family
BI313_RS06885	COG2095	MarC family integral membrane protein
BI313_RS06895	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
BI313_RS06930	COG1185	polyribonucleotide nucleotidyltransferase activity
BI313_RS06935	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BI313_RS06940	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BI313_RS06945	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BI313_RS06950	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BI313_RS06955	COG0195	Participates in both transcription termination and antitermination
BI313_RS06960	COG0779	Required for maturation of 30S ribosomal subunits
BI313_RS06970	COG1007	ATP synthesis coupled electron transport
BI313_RS07005	COG1034	ATP synthesis coupled electron transport
BI313_RS07010	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
BI313_RS07015	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
BI313_RS07020	COG0649	NAD binding
BI313_RS07025	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BI313_RS07035	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BI313_RS07050	COG0149	triose-phosphate isomerase activity
BI313_RS07085	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BI313_RS07090	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
BI313_RS07105	COG0133	tryptophan synthase activity
BI313_RS07120	COG0101	tRNA pseudouridine synthase activity
BI313_RS07135	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BI313_RS07140	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BI313_RS07145	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BI313_RS07155	COG2890	protein-(glutamine-N5) methyltransferase activity
BI313_RS07165	COG0688	phosphatidylethanolamine metabolic process
BI313_RS07175	COG0741	lytic transglycosylase activity
BI313_RS07180	COG0433	COG0433 Predicted ATPase
BI313_RS07190	COG0494	nUDIX hydrolase
BI313_RS07210	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BI313_RS07240	COG0717	Belongs to the dCTP deaminase family
BI313_RS07250	COG0489	protein tyrosine kinase activity
BI313_RS07265	COG3590	peptidase
BI313_RS07270	COG3590	peptidase
BI313_RS07290	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BI313_RS07295	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BI313_RS07300	COG2311	Membrane
BI313_RS07305	COG1047	Peptidyl-prolyl cis-trans
BI313_RS07310	COG0791	NLP P60 protein
BI313_RS07315	COG0791	NLP P60 protein
BI313_RS07360	COG2226	methyltransferase
BI313_RS07365	COG1301	dicarboxylic acid transport
BI313_RS07370	COG1785	Belongs to the alkaline phosphatase family
BI313_RS07375	COG0037	tRNA processing
BI313_RS07380	COG1722	exodeoxyribonuclease VII activity
BI313_RS07385	COG0142	geranyltranstransferase activity
BI313_RS07395	COG4104	PAAR repeat-containing protein
BI313_RS07405	COG0312	modulator of DNA gyrase
BI313_RS07410	COG3028	Belongs to the UPF0307 family
BI313_RS07415	COG0312	modulator of DNA gyrase
BI313_RS07435	COG0424	maF-like protein
BI313_RS07440	COG2968	Membrane
BI313_RS07470	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BI313_RS07485	COG0495	leucyl-tRNA aminoacylation
BI313_RS07495	COG3118	belongs to the thioredoxin family
BI313_RS07505	COG2155	Conserved Protein
BI313_RS07560	COG1132	(ABC) transporter
BI313_RS07570	COG0475	glutathione-regulated potassium exporter activity
BI313_RS07580	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BI313_RS07615	COG1187	pseudouridine synthase activity
BI313_RS07620	COG5001	Diguanylate cyclase
BI313_RS07620	COG5002	protein histidine kinase activity
BI313_RS07670	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
BI313_RS07755	COG0667	Aldo Keto reductase
BI313_RS07760	COG2814	Major facilitator Superfamily
BI313_RS07765	COG0583	DNA-binding transcription factor activity
BI313_RS07775	COG2207	Transcriptional regulator
BI313_RS07790	COG0667	Aldo Keto reductase
BI313_RS07795	COG1309	transcriptional regulator
BI313_RS07820	COG0735	belongs to the Fur family
BI313_RS07850	COG4452	Inner membrane protein CreD
BI313_RS07855	COG2205	protein histidine kinase activity
BI313_RS07860	COG0745	RESPONSE REGULATOR receiver
BI313_RS07865	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
BI313_RS07885	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BI313_RS07895	COG0643	Histidine kinase
BI313_RS07895	COG2198	Histidine kinase
BI313_RS07905	COG0840	transmembrane signaling receptor activity
BI313_RS07910	COG0835	chemotaxis
BI313_RS07935	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BI313_RS07940	COG3590	peptidase
BI313_RS07950	COG0588	phosphoglycerate mutase activity
BI313_RS07970	COG1741	Belongs to the pirin family
BI313_RS07985	COG1741	Belongs to the pirin family
BI313_RS07990	COG1966	Carbon starvation protein
BI313_RS07995	COG2879	small protein
BI313_RS08035	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
BI313_RS08040	COG1529	Aldehyde oxidase and xanthine dehydrogenase
BI313_RS08050	COG2080	2 iron, 2 sulfur cluster binding
BI313_RS08055	COG1028	Short-chain dehydrogenase reductase Sdr
BI313_RS08055	COG3321	synthase
BI313_RS08055	COG0604	alcohol dehydrogenase
BI313_RS08065	COG0629	single-stranded DNA binding
BI313_RS08070	COG0142	geranyltranstransferase activity
BI313_RS08080	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BI313_RS08095	COG0527	aspartate kinase activity
BI313_RS08100	COG0384	phenazine biosynthesis protein PhzF
BI313_RS08105	COG0384	phenazine biosynthesis protein PhzF
BI313_RS08115	COG1764	response to oxidative stress
BI313_RS08125	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BI313_RS08130	COG1678	Uncharacterized ACR, COG1678
BI313_RS08135	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
BI313_RS08140	COG0519	Catalyzes the synthesis of GMP from XMP
BI313_RS08170	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BI313_RS08210	COG0693	protein deglycase activity
BI313_RS08220	COG1959	2 iron, 2 sulfur cluster binding
BI313_RS08225	COG0719	Fe-S assembly protein
BI313_RS08230	COG0396	ATPase activity
BI313_RS08235	COG0719	Fe-S assembly protein
BI313_RS08240	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BI313_RS08250	COG0456	acetyltransferase
BI313_RS08255	COG2146	nitrite reductase [NAD(P)H] activity
BI313_RS08260	COG4774	siderophore transport
BI313_RS08295	COG1477	protein flavinylation
BI313_RS08310	COG1555	photosystem II stabilization
BI313_RS08315	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BI313_RS08330	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
BI313_RS08340	COG0628	permease
BI313_RS08350	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BI313_RS08365	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BI313_RS08405	COG0271	Belongs to the BolA IbaG family
BI313_RS08415	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
BI313_RS08425	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
BI313_RS08430	COG1137	ATPase activity
BI313_RS08445	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BI313_RS08455	COG1660	Displays ATPase and GTPase activities
BI313_RS08465	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BI313_RS08470	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BI313_RS08475	COG2239	Acts as a magnesium transporter
BI313_RS08485	COG1294	oxidase, subunit
BI313_RS08490	COG1271	oxidase subunit
BI313_RS08495	COG1113	amino acid transport
BI313_RS08510	COG2197	response regulator
BI313_RS08515	COG0531	amino acid
BI313_RS08575	COG2814	Major facilitator Superfamily
BI313_RS08580	COG0754	glutathionylspermidine amidase activity
BI313_RS08605	COG1842	Phage shock protein A
BI313_RS08625	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BI313_RS08640	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
BI313_RS08645	COG2814	Major facilitator Superfamily
BI313_RS08665	COG2353	YceI-like domain
BI313_RS08680	COG1278	Cold shock
BI313_RS08695	COG1760	l-serine dehydratase
BI313_RS08705	COG0527	aspartate kinase activity
BI313_RS08705	COG0460	homoserine dehydrogenase
BI313_RS08710	COG0626	cystathionine gamma-synthase activity
BI313_RS08715	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BI313_RS08720	COG0739	heme binding
BI313_RS08725	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
BI313_RS08730	COG1272	protein, Hemolysin III
BI313_RS08735	COG2982	Protein involved in outer membrane biogenesis
BI313_RS08740	COG0516	GMP reductase activity
BI313_RS08740	COG0517	IMP dehydrogenase activity
BI313_RS08750	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BI313_RS08755	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
BI313_RS08765	COG4771	TonB-dependent receptor
BI313_RS08770	COG1309	transcriptional regulator
BI313_RS08780	COG1960	acyl-CoA dehydrogenase activity
BI313_RS08810	COG0509	glycine decarboxylation via glycine cleavage system
BI313_RS08815	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BI313_RS08825	COG0330	HflC and HflK could
BI313_RS08835	COG3956	TIGRFAM MazG family protein
BI313_RS08840	COG1218	3'(2'),5'-bisphosphate nucleotidase
BI313_RS08845	COG0494	nUDIX hydrolase
BI313_RS08855	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BI313_RS08875	COG1388	LysM domain
BI313_RS08875	COG3858	chitin binding
BI313_RS08895	COG1472	Belongs to the glycosyl hydrolase 3 family
BI313_RS08905	COG3537	Alpha-1,2-mannosidase
BI313_RS08945	COG3142	Participates in the control of copper homeostasis
BI313_RS08950	COG1446	asparaginase
BI313_RS08955	COG2304	oxidoreductase activity
BI313_RS08985	COG0643	Histidine kinase
BI313_RS08985	COG0784	Response regulator, receiver
BI313_RS08985	COG2198	Histidine kinase
BI313_RS08990	COG0840	transmembrane signaling receptor activity
BI313_RS08995	COG0835	chemotaxis
BI313_RS09010	COG0189	ligase activity
BI313_RS09020	COG1397	ADP-ribosylglycohydrolase
BI313_RS09030	COG1199	ATP-dependent helicase activity
BI313_RS09040	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BI313_RS09045	COG1216	Glycosyl transferase, family 2
BI313_RS09055	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BI313_RS09065	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
BI313_RS09070	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
BI313_RS09095	COG0837	glucose binding
BI313_RS09105	COG1643	Atp-dependent helicase
BI313_RS09110	COG0783	Belongs to the Dps family
BI313_RS09115	COG0514	ATP-dependent DNA helicase (RecQ)
BI313_RS09135	COG1187	pseudouridine synthase activity
BI313_RS09145	COG0840	transmembrane signaling receptor activity
BI313_RS09155	COG2202	Pas domain
BI313_RS09155	COG3920	Histidine kinase
BI313_RS09170	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
BI313_RS09175	COG0602	queuosine metabolic process
BI313_RS09185	COG2885	chlorophyll binding
BI313_RS09190	COG0823	Involved in the tonB-independent uptake of proteins
BI313_RS09200	COG0848	biopolymer transport protein
BI313_RS09210	COG0824	Thioesterase
BI313_RS09215	COG2255	four-way junction helicase activity
BI313_RS09230	COG0632	four-way junction helicase activity
BI313_RS09235	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
BI313_RS09255	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BI313_RS09275	COG0477	Major facilitator Superfamily
BI313_RS09295	COG0640	Transcriptional regulator
BI313_RS09300	COG0730	response to heat
BI313_RS09325	COG2755	lipolytic protein G-D-S-L family
BI313_RS09325	COG0657	acetylesterase activity
BI313_RS09340	COG2951	lytic endotransglycosylase activity
BI313_RS09350	COG0488	(ABC) transporter
BI313_RS09385	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BI313_RS09385	COG4651	solute:proton antiporter activity
BI313_RS09395	COG4772	TonB-dependent receptor
BI313_RS09405	COG4264	IucA IucC family
BI313_RS09415	COG4264	IucA IucC family
BI313_RS09420	COG0019	diaminopimelate decarboxylase activity
BI313_RS09440	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
BI313_RS09450	COG1492	cobalamin metabolic process
BI313_RS09460	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
BI313_RS09480	COG4206	TonB-dependent receptor
BI313_RS09490	COG0542	response to heat
BI313_RS09540	COG3387	PFAM Glycoside hydrolase 15-related
BI313_RS09550	COG4993	Dehydrogenase
BI313_RS09555	COG0840	transmembrane signaling receptor activity
BI313_RS09560	COG3011	Protein conserved in bacteria
BI313_RS09575	COG0564	pseudouridine synthase activity
BI313_RS09580	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BI313_RS09590	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
BI313_RS09590	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BI313_RS09605	COG0045	succinate-CoA ligase (ADP-forming) activity
BI313_RS09660	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
BI313_RS09665	COG0237	dephospho-CoA kinase activity
BI313_RS09675	COG0745	RESPONSE REGULATOR receiver
BI313_RS09685	COG0189	ligase activity
BI313_RS09720	COG1074	ATP-dependent DNA helicase activity
BI313_RS09935	COG2003	Belongs to the UPF0758 family
BI313_RS10020	COG3273	potassium ion transport
BI313_RS10020	COG0471	metal ion transport
BI313_RS10040	COG1970	mechanosensitive ion channel activity
BI313_RS10050	COG1609	Transcriptional regulator
BI313_RS10060	COG5297	Belongs to the glycosyl hydrolase family 6
BI313_RS10070	COG3250	beta-galactosidase activity
BI313_RS10075	COG4948	Mandelate Racemase Muconate Lactonizing
BI313_RS10080	COG2272	Belongs to the type-B carboxylesterase lipase family
BI313_RS10085	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BI313_RS10090	COG1115	amino acid carrier protein
BI313_RS10105	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BI313_RS10110	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BI313_RS10115	COG0529	Catalyzes the synthesis of activated sulfate
BI313_RS10115	COG2895	sulfate adenylyltransferase (ATP) activity
BI313_RS10125	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BI313_RS10130	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BI313_RS10135	COG0175	sulfate reduction
BI313_RS10155	COG2205	protein histidine kinase activity
BI313_RS10155	COG2198	Histidine kinase
BI313_RS10155	COG0784	Response regulator, receiver
BI313_RS10170	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BI313_RS10170	COG1648	precorrin-2 dehydrogenase activity
BI313_RS10185	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
BI313_RS10190	COG3588	fructose-bisphosphate aldolase
BI313_RS10200	COG0469	pyruvate kinase activity
BI313_RS10230	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BI313_RS10250	COG3047	cAMP biosynthetic process
BI313_RS10260	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BI313_RS10260	COG3453	Protein conserved in bacteria
BI313_RS10265	COG0725	ABC transporter, periplasmic molybdate-binding protein
BI313_RS10270	COG4149	molybdate abc transporter
BI313_RS10275	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
BI313_RS10310	COG1376	ErfK ybiS ycfS ynhG family protein
BI313_RS10315	COG0739	heme binding
BI313_RS10325	COG1028	Short-chain dehydrogenase reductase Sdr
BI313_RS10330	COG0583	DNA-binding transcription factor activity
BI313_RS10335	COG4773	Receptor
BI313_RS10340	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
BI313_RS10345	COG1301	dicarboxylic acid transport
BI313_RS10355	COG2304	oxidoreductase activity
BI313_RS10375	COG0714	Associated with various cellular activities
BI313_RS10405	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
BI313_RS10430	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BI313_RS10440	COG2721	sulfolactate sulfo-lyase activity
BI313_RS10455	COG2271	Major facilitator Superfamily
BI313_RS10470	COG0583	DNA-binding transcription factor activity
BI313_RS10480	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BI313_RS10485	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BI313_RS10490	COG2390	Transcriptional regulator
BI313_RS10500	COG3659	wide pore channel activity
BI313_RS10505	COG4209	transmembrane transport
BI313_RS10520	COG1028	Short-chain dehydrogenase reductase Sdr
BI313_RS10540	COG1561	YicC-like family, N-terminal region
BI313_RS10545	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
BI313_RS10555	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BI313_RS10560	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BI313_RS10575	COG0006	proline dipeptidase activity
BI313_RS10590	COG0006	proline dipeptidase activity
BI313_RS10615	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BI313_RS10635	COG2912	Transglutaminase-like superfamily
BI313_RS10640	COG1773	rubredoxin
BI313_RS10645	COG0352	thiamine-phosphate diphosphorylase activity
BI313_RS10730	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BI313_RS10855	COG2963	transposase activity
BI313_RS10860	COG2801	Transposase and inactivated derivatives
BI313_RS10870	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BI313_RS10885	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BI313_RS10915	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BI313_RS10920	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BI313_RS10950	COG0671	phosphoesterase, PA-phosphatase related
BI313_RS10955	COG3781	membrane
BI313_RS10965	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BI313_RS10970	COG0563	adenylate kinase activity
BI313_RS11090	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
BI313_RS11100	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
BI313_RS11120	COG3710	Transcriptional regulator
BI313_RS11135	COG0840	transmembrane signaling receptor activity
BI313_RS11145	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
BI313_RS11165	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BI313_RS11175	COG0473	3-isopropylmalate dehydrogenase activity
BI313_RS11180	COG2226	methyltransferase
BI313_RS11185	COG0066	3-isopropylmalate dehydratase activity
BI313_RS11190	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BI313_RS11210	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BI313_RS11215	COG1538	Outer membrane efflux protein
BI313_RS11225	COG1519	Transferase
BI313_RS11230	COG1560	Kdo2-lipid A biosynthetic process
BI313_RS11255	COG0281	malic enzyme
BI313_RS11255	COG0280	phosphate acetyltransferase
BI313_RS11270	COG4191	Histidine kinase
BI313_RS11280	COG0667	Aldo Keto reductase
BI313_RS11295	COG2197	response regulator
BI313_RS11305	COG0642	Histidine kinase
BI313_RS11320	COG2851	Citrate transporter
BI313_RS11325	COG1028	Short-chain dehydrogenase reductase Sdr
BI313_RS11330	COG1609	Transcriptional regulator
BI313_RS11335	COG2211	Major facilitator Superfamily
BI313_RS11365	COG0436	Aminotransferase
BI313_RS11380	COG0726	polysaccharide deacetylase
BI313_RS11385	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
BI313_RS11400	COG3964	amidohydrolase
BI313_RS11405	COG0402	S-adenosylhomocysteine deaminase activity
BI313_RS11445	COG1307	EDD domain protein, DegV family
BI313_RS11460	COG3791	Glutathione-dependent formaldehyde-activating
BI313_RS11475	COG0583	DNA-binding transcription factor activity
BI313_RS11495	COG2205	protein histidine kinase activity
BI313_RS11525	COG0218	Necessary for normal cell division and for the maintenance of normal septation
BI313_RS11540	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BI313_RS11550	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BI313_RS11555	COG1012	belongs to the aldehyde dehydrogenase family
BI313_RS11560	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
BI313_RS11610	COG1183	phosphatidylcholine synthase activity
BI313_RS11620	COG0442	prolyl-tRNA aminoacylation
BI313_RS11635	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BI313_RS11640	COG1127	ABC transporter
BI313_RS11645	COG3218	ABC-type transport auxiliary lipoprotein component
BI313_RS11645	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BI313_RS11685	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BI313_RS11690	COG0662	Cupin 2, conserved barrel domain protein
BI313_RS11690	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
BI313_RS11720	COG2086	electron transfer activity
BI313_RS11730	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BI313_RS11735	COG0463	Glycosyl transferase, family 2
BI313_RS11775	COG1682	transport, permease protein
BI313_RS11780	COG0626	cystathionine gamma-synthase activity
BI313_RS11815	COG0625	glutathione transferase activity
BI313_RS11830	COG0513	Belongs to the DEAD box helicase family
BI313_RS11835	COG0720	synthase
BI313_RS11845	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
BI313_RS11850	COG1956	GAF domain-containing protein
BI313_RS11865	COG0546	phosphoglycolate phosphatase activity
BI313_RS11875	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BI313_RS11895	COG0339	signal peptide processing
BI313_RS11955	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BI313_RS11960	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BI313_RS11965	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BI313_RS11970	COG4591	ABC-type transport system involved in lipoprotein release permease component
BI313_RS11970	COG1136	(ABC) transporter
BI313_RS11995	COG4191	Histidine kinase
BI313_RS12005	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BI313_RS12020	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BI313_RS12030	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BI313_RS12035	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BI313_RS12040	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BI313_RS12045	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BI313_RS12055	COG0356	it plays a direct role in the translocation of protons across the membrane
BI313_RS12070	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BI313_RS12080	COG0508	dehydrogenase complex catalyzes the overall conversion of
BI313_RS12110	COG2011	ABC-type metal ion transport system permease component
BI313_RS12115	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BI313_RS12120	COG0697	spore germination
BI313_RS12125	COG1666	GTP binding
BI313_RS12155	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BI313_RS12160	COG1187	pseudouridine synthase activity
BI313_RS12165	COG2813	Specifically methylates the guanine in position
BI313_RS12185	COG2205	protein histidine kinase activity
BI313_RS12185	COG0784	Response regulator, receiver
BI313_RS12205	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BI313_RS12210	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BI313_RS12265	COG0842	Transport permease protein
BI313_RS12270	COG1131	(ABC) transporter
BI313_RS12275	COG0025	NhaP-type Na H and K H
BI313_RS12295	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
BI313_RS12300	COG1573	uracil-dna glycosylase
BI313_RS12315	COG3384	dioxygenase
BI313_RS12320	COG0583	DNA-binding transcription factor activity
BI313_RS12330	COG0667	Aldo Keto reductase
BI313_RS12340	COG3590	peptidase
BI313_RS12360	COG0531	amino acid
BI313_RS12375	COG3275	phosphorelay sensor kinase activity
BI313_RS12390	COG3685	Protein conserved in bacteria
BI313_RS12395	COG3546	catalase activity
BI313_RS12425	COG2204	response regulator
BI313_RS12445	COG1294	oxidase, subunit
BI313_RS12460	COG1028	Short-chain dehydrogenase reductase Sdr
BI313_RS12470	COG1063	alcohol dehydrogenase
BI313_RS12495	COG1529	Aldehyde oxidase and xanthine dehydrogenase
BI313_RS12545	COG1131	(ABC) transporter
BI313_RS12555	COG0251	oxidation-reduction process
BI313_RS12560	COG0840	transmembrane signaling receptor activity
BI313_RS12585	COG0038	chloride channel
BI313_RS12595	COG0024	Methionine aminopeptidase
BI313_RS12605	COG1733	regulation of RNA biosynthetic process
BI313_RS12615	COG1999	signal sequence binding
BI313_RS12625	COG1335	isochorismatase
BI313_RS12670	COG1487	ribonuclease activity
BI313_RS12680	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
BI313_RS12680	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BI313_RS12685	COG1074	ATP-dependent DNA helicase activity
BI313_RS12715	COG0419	ATPase involved in DNA repair
BI313_RS12775	COG1196	nuclear chromosome segregation
BI313_RS12830	COG0582	viral genome integration into host DNA
BI313_RS12845	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BI313_RS12850	COG1490	D-aminoacyl-tRNA deacylase activity
BI313_RS12855	COG1560	Kdo2-lipid A biosynthetic process
BI313_RS12860	COG1247	-acetyltransferase
BI313_RS12900	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BI313_RS12900	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BI313_RS12905	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BI313_RS12910	COG0242	peptide deformylase activity
BI313_RS12915	COG1652	LysM domain
BI313_RS12920	COG0758	DNA mediated transformation
BI313_RS12940	COG1754	DNA topoisomerase type I activity
BI313_RS12940	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BI313_RS12945	COG0009	L-threonylcarbamoyladenylate synthase
BI313_RS12960	COG1028	Short-chain dehydrogenase reductase Sdr
BI313_RS12970	COG0616	signal peptide processing
BI313_RS12975	COG0534	Mate efflux family protein
BI313_RS12995	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BI313_RS13000	COG0625	glutathione transferase activity
BI313_RS13015	COG1252	NADH dehydrogenase
BI313_RS13020	COG2860	membrane
BI313_RS13025	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BI313_RS13035	COG3437	response regulator, receiver
BI313_RS13040	COG2177	Part of the ABC transporter FtsEX involved in
BI313_RS13045	COG2884	Cell division ATP-binding protein ftsE
BI313_RS13055	COG3118	belongs to the thioredoxin family
BI313_RS13060	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
BI313_RS13070	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
BI313_RS13075	COG0583	DNA-binding transcription factor activity
BI313_RS13095	COG1652	LysM domain
BI313_RS13100	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BI313_RS13100	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BI313_RS13105	COG1473	amidohydrolase
BI313_RS13110	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BI313_RS13135	COG5383	Protein conserved in bacteria
BI313_RS13175	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
BI313_RS13180	COG3023	N-Acetylmuramoyl-L-alanine amidase
BI313_RS13190	COG4948	Mandelate Racemase Muconate Lactonizing
BI313_RS13200	COG0531	amino acid
BI313_RS13215	COG4682	membrane
BI313_RS13220	COG2133	pyrroloquinoline quinone binding
BI313_RS13230	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BI313_RS13235	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BI313_RS13245	COG1610	YqeY-like protein
BI313_RS13250	COG1295	ribonuclease BN
BI313_RS13255	COG0358	DNA primase activity
BI313_RS13310	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
BI313_RS13325	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BI313_RS13370	COG0739	heme binding
BI313_RS13385	COG2211	Major facilitator Superfamily
BI313_RS13395	COG0708	Exodeoxyribonuclease III
BI313_RS13410	COG1192	Involved in chromosome partitioning
BI313_RS13415	COG1475	DNA binding
BI313_RS13435	COG0463	Glycosyl transferase, family 2
BI313_RS13455	COG0756	dUTP diphosphatase activity
BI313_RS13460	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BI313_RS13470	COG0018	arginyl-trna synthetase
BI313_RS13485	COG4221	oxidoreductase activity
BI313_RS13490	COG2755	lipolytic protein G-D-S-L family
BI313_RS13490	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
BI313_RS13510	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BI313_RS13515	COG1166	arginine decarboxylase activity
BI313_RS13520	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
BI313_RS13540	COG3525	Glycosyl hydrolase, family 20, catalytic domain
BI313_RS13540	COG3291	Pkd domain containing protein
BI313_RS13555	COG2960	long-chain fatty acid transporting porin activity
BI313_RS13560	COG0606	chelatase, subunit chli
BI313_RS13575	COG4943	cyclic-guanylate-specific phosphodiesterase activity
BI313_RS13605	COG1690	Belongs to the RtcB family
BI313_RS13640	COG1090	epimerase
BI313_RS13650	COG0642	Histidine kinase
BI313_RS13670	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BI313_RS13690	COG0628	permease
BI313_RS13700	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BI313_RS13715	COG0753	catalase activity
BI313_RS13730	COG2197	response regulator
BI313_RS13740	COG4585	Histidine kinase
BI313_RS13745	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BI313_RS13750	COG1136	(ABC) transporter
BI313_RS13775	COG0697	spore germination
BI313_RS13795	COG0180	Tryptophanyl-tRNA synthetase
BI313_RS13800	COG3237	CsbD-like
BI313_RS13840	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BI313_RS13855	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
BI313_RS13860	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
BI313_RS13860	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
BI313_RS13870	COG3228	Belongs to the MtfA family
BI313_RS13900	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BI313_RS13925	COG1199	ATP-dependent helicase activity
BI313_RS13950	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BI313_RS13985	COG0625	glutathione transferase activity
BI313_RS14020	COG4555	ABC transporter
BI313_RS14030	COG1476	TRANSCRIPTIONal
BI313_RS14055	COG0543	2 iron, 2 sulfur cluster binding
BI313_RS14055	COG0633	Ferredoxin
BI313_RS14060	COG1131	(ABC) transporter
BI313_RS14065	COG0842	Transport permease protein
BI313_RS14070	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BI313_RS14080	COG1607	acyl-coa hydrolase
BI313_RS14085	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BI313_RS14100	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BI313_RS14105	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BI313_RS14130	COG0045	succinate-CoA ligase (ADP-forming) activity
BI313_RS14130	COG1042	CoA-binding domain protein
BI313_RS14130	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BI313_RS14135	COG2239	Acts as a magnesium transporter
BI313_RS14140	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BI313_RS14140	COG0475	glutathione-regulated potassium exporter activity
BI313_RS14145	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BI313_RS14150	COG3387	PFAM Glycoside hydrolase 15-related
BI313_RS14165	COG3100	YcgL domain-containing protein
BI313_RS14170	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BI313_RS14205	COG1028	Short-chain dehydrogenase reductase Sdr
BI313_RS14230	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BI313_RS14245	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BI313_RS14295	COG0408	coproporphyrinogen oxidase activity
BI313_RS14330	COG0515	serine threonine protein kinase
BI313_RS14335	COG0631	protein serine/threonine phosphatase activity
BI313_RS14360	COG0667	Aldo Keto reductase
BI313_RS14365	COG0583	DNA-binding transcription factor activity
BI313_RS14510	COG0210	DNA helicase
BI313_RS14525	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BI313_RS14530	COG0583	DNA-binding transcription factor activity
BI313_RS14535	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BI313_RS14545	COG2159	amidohydrolase
BI313_RS14595	COG2091	lysine biosynthetic process via aminoadipic acid
BI313_RS14625	COG3162	membrane
BI313_RS14665	COG3507	Belongs to the glycosyl hydrolase 43 family
BI313_RS14680	COG1028	Short-chain dehydrogenase reductase Sdr
BI313_RS14685	COG0179	Fumarylacetoacetate (FAA) hydrolase
BI313_RS14690	COG4948	Mandelate Racemase Muconate Lactonizing
BI313_RS14695	COG3254	rhamnose metabolic process
BI313_RS14700	COG0738	Major facilitator superfamily
BI313_RS14705	COG1414	Transcriptional regulator
BI313_RS14715	COG0784	Response regulator, receiver
BI313_RS14715	COG2205	protein histidine kinase activity
BI313_RS14730	COG3459	Glycosyltransferase 36 associated
BI313_RS14735	COG2211	Major facilitator Superfamily
BI313_RS14740	COG3265	gluconokinase activity
BI313_RS14745	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BI313_RS14770	COG0729	surface antigen
BI313_RS14775	COG4771	TonB-dependent receptor
BI313_RS14780	COG0457	Tetratricopeptide repeat
BI313_RS14795	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BI313_RS14805	COG0519	Catalyzes the synthesis of GMP from XMP
BI313_RS14805	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BI313_RS14820	COG0805	protein transport
BI313_RS14830	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BI313_RS14840	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
BI313_RS14860	COG2974	May be involved in recombination
BI313_RS14865	COG0037	tRNA processing
BI313_RS14875	COG2115	Belongs to the xylose isomerase family
BI313_RS14885	COG3661	Belongs to the glycosyl hydrolase 67 family
BI313_RS14895	COG4948	Mandelate Racemase Muconate Lactonizing
BI313_RS14905	COG1472	Belongs to the glycosyl hydrolase 3 family
BI313_RS14910	COG0246	Mannitol dehydrogenase
BI313_RS14940	COG3386	PFAM SMP-30 Gluconolaconase
BI313_RS14950	COG3250	beta-galactosidase activity
BI313_RS14955	COG1904	glucuronate isomerase
BI313_RS14960	COG3693	PFAM glycoside hydrolase, family 10
BI313_RS14975	COG2211	Major facilitator Superfamily
BI313_RS15015	COG0604	alcohol dehydrogenase
BI313_RS15015	COG1028	Short-chain dehydrogenase reductase Sdr
BI313_RS15015	COG3321	synthase
BI313_RS15020	COG2937	Belongs to the GPAT DAPAT family
BI313_RS15055	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
BI313_RS15060	COG3132	Protein of unknown function, DUF480
BI313_RS15075	COG0210	DNA helicase
BI313_RS15080	COG1435	thymidine kinase activity
BI313_RS15090	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
BI313_RS15100	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BI313_RS15130	COG3135	benzoate transporter
BI313_RS15150	COG0676	glucose-6-phosphate 1-epimerase activity
BI313_RS15165	COG0730	response to heat
BI313_RS15185	COG0302	gtp cyclohydrolase
BI313_RS15200	COG1566	PFAM secretion protein HlyD family protein
BI313_RS15210	COG1289	transmembrane transporter activity
BI313_RS15215	COG0477	Major facilitator Superfamily
BI313_RS15225	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BI313_RS15290	COG0564	pseudouridine synthase activity
BI313_RS15295	COG2963	transposase activity
BI313_RS15300	COG2801	Transposase and inactivated derivatives
BI313_RS15340	COG3549	Plasmid maintenance system killer
BI313_RS15345	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BI313_RS15350	COG1074	ATP-dependent DNA helicase activity
BI313_RS15355	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
BI313_RS15395	COG1127	ABC transporter
BI313_RS15400	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BI313_RS15405	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BI313_RS15420	COG2853	Lipoprotein
BI313_RS15430	COG0386	Belongs to the glutathione peroxidase family
BI313_RS15440	COG1322	Protein conserved in bacteria
BI313_RS15445	COG0604	alcohol dehydrogenase
BI313_RS15460	COG0625	glutathione transferase activity
BI313_RS15470	COG0531	amino acid
BI313_RS15475	COG3537	Alpha-1,2-mannosidase
BI313_RS15490	COG3706	GGDEF domain
BI313_RS15495	COG1929	Belongs to the glycerate kinase type-1 family
BI313_RS15515	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BI313_RS15525	COG0861	Integral membrane protein TerC family
BI313_RS15540	COG0584	glycerophosphoryl diester phosphodiesterase
BI313_RS15555	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BI313_RS15565	COG0726	polysaccharide deacetylase
BI313_RS15570	COG0706	membrane insertase activity
BI313_RS15590	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BI313_RS15605	COG0187	DNA topoisomerase II activity
BI313_RS15615	COG0501	Belongs to the peptidase M48B family
BI313_RS15660	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
BI313_RS15670	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BI313_RS15700	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BI313_RS15705	COG0793	Belongs to the peptidase S41A family
BI313_RS15715	COG4942	peptidase
BI313_RS15725	COG2234	aminopeptidase activity
BI313_RS15735	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BI313_RS15740	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BI313_RS15745	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BI313_RS15750	COG1064	alcohol dehydrogenase
BI313_RS15760	COG0493	'glutamate synthase
BI313_RS15765	COG0067	glutamate synthase
BI313_RS15765	COG0069	glutamate synthase activity
BI313_RS15765	COG0070	glutamate synthase
BI313_RS15800	COG0583	DNA-binding transcription factor activity
BI313_RS15875	COG1205	dead DEAH box helicase
BI313_RS15875	COG1111	helicase
BI313_RS15880	COG1272	protein, Hemolysin III
BI313_RS15890	COG0625	glutathione transferase activity
BI313_RS15900	COG3590	peptidase
BI313_RS15905	COG0583	DNA-binding transcription factor activity
BI313_RS15910	COG1028	Short-chain dehydrogenase reductase Sdr
BI313_RS15930	COG2249	NAD(P)H dehydrogenase (quinone) activity
BI313_RS15940	COG1733	regulation of RNA biosynthetic process
BI313_RS15975	COG3237	CsbD-like
BI313_RS16020	COG1309	transcriptional regulator
BI313_RS16040	COG0628	permease
BI313_RS16045	COG0657	acetylesterase activity
BI313_RS16055	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BI313_RS16060	COG0477	Major facilitator Superfamily
BI313_RS16105	COG0714	Associated with various cellular activities
BI313_RS16140	COG0596	Alpha beta hydrolase
BI313_RS16150	COG1309	transcriptional regulator
BI313_RS16155	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
BI313_RS16165	COG4772	TonB-dependent receptor
BI313_RS16180	COG1012	belongs to the aldehyde dehydrogenase family
BI313_RS16225	COG1755	Isoprenylcysteine carboxyl methyltransferase
BI313_RS16230	COG4585	Histidine kinase
BI313_RS16235	COG2197	response regulator
BI313_RS16245	COG3710	Transcriptional regulator
BI313_RS16250	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
BI313_RS16260	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BI313_RS16390	COG0366	Alpha amylase catalytic
BI313_RS16395	COG0366	Alpha amylase catalytic
BI313_RS16435	COG2755	lipolytic protein G-D-S-L family
BI313_RS16445	COG0657	acetylesterase activity
BI313_RS16445	COG2755	lipolytic protein G-D-S-L family
BI313_RS16455	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BI313_RS16470	COG3507	Belongs to the glycosyl hydrolase 43 family
BI313_RS16475	COG1609	Transcriptional regulator
BI313_RS16485	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
BI313_RS16490	COG1028	Short-chain dehydrogenase reductase Sdr
BI313_RS16505	COG2755	lipolytic protein G-D-S-L family
BI313_RS16515	COG3186	Phenylalanine-4-hydroxylase
BI313_RS16520	COG1522	sequence-specific DNA binding
BI313_RS16535	COG1752	Esterase of the alpha-beta hydrolase superfamily
BI313_RS16545	COG1119	ATPase activity
BI313_RS16560	COG1125	glycine betaine transport
BI313_RS16560	COG0517	IMP dehydrogenase activity
BI313_RS16575	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BI313_RS16580	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
BI313_RS16605	COG0489	protein tyrosine kinase activity
BI313_RS16610	COG2062	phosphohistidine phosphatase, SixA
BI313_RS16615	COG2353	YceI-like domain
BI313_RS16620	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BI313_RS16650	COG1881	PFAM PEBP family protein
BI313_RS16670	COG0174	glutamine synthetase
BI313_RS16675	COG0347	Belongs to the P(II) protein family
BI313_RS16680	COG0004	ammonium transporteR
BI313_RS16685	COG3852	Histidine kinase
BI313_RS16690	COG2204	response regulator
BI313_RS16695	COG2032	superoxide dismutase activity
BI313_RS16700	COG2032	superoxide dismutase activity
BI313_RS16715	COG0183	Belongs to the thiolase family
BI313_RS16755	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BI313_RS16760	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
BI313_RS16765	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BI313_RS16775	COG0028	Belongs to the TPP enzyme family
BI313_RS16780	COG2205	protein histidine kinase activity
BI313_RS16785	COG2204	response regulator
BI313_RS16805	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
BI313_RS16820	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BI313_RS16825	COG3177	Filamentation induced by cAMP protein fic
BI313_RS16830	COG0596	Alpha beta hydrolase
BI313_RS16835	COG0727	PFAM Uncharacterised protein family (UPF0153)
BI313_RS16840	COG0318	PFAM AMP-dependent synthetase and ligase
BI313_RS16845	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BI313_RS16860	COG1181	Belongs to the D-alanine--D-alanine ligase family
BI313_RS16870	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BI313_RS16880	COG0564	pseudouridine synthase activity
BI313_RS16910	COG0339	signal peptide processing
BI313_RS16915	COG0339	signal peptide processing
BI313_RS16945	COG0475	glutathione-regulated potassium exporter activity
BI313_RS16950	COG0583	DNA-binding transcription factor activity
BI313_RS16955	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
BI313_RS16960	COG2224	Isocitrate lyase
BI313_RS16995	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BI313_RS17000	COG1960	acyl-CoA dehydrogenase activity
BI313_RS17060	COG0523	cobalamin synthesis protein
BI313_RS17075	COG0697	spore germination
BI313_RS17085	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
BI313_RS17090	COG1846	Transcriptional regulator
BI313_RS17095	COG1764	response to oxidative stress
BI313_RS17130	COG0656	L-ascorbic acid biosynthetic process
BI313_RS17135	COG2130	NADP-dependent
BI313_RS17150	COG1187	pseudouridine synthase activity
BI313_RS17160	COG1643	Atp-dependent helicase
BI313_RS17165	COG0840	transmembrane signaling receptor activity
BI313_RS17170	COG4807	Protein conserved in bacteria
BI313_RS17175	COG2351	hydroxyisourate hydrolase activity
BI313_RS17180	COG2072	flavoprotein involved in K transport
BI313_RS17200	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BI313_RS17240	COG1957	nucleoside hydrolase
BI313_RS17250	COG2252	PERMEase
BI313_RS17265	COG0583	DNA-binding transcription factor activity
BI313_RS17270	COG0084	hydrolase, TatD family'
BI313_RS17285	COG0583	DNA-binding transcription factor activity
BI313_RS17290	COG2814	Major facilitator Superfamily
BI313_RS17305	COG1028	Short-chain dehydrogenase reductase Sdr
BI313_RS17320	COG1902	pentaerythritol trinitrate reductase activity
BI313_RS17345	COG0300	oxidoreductase activity
BI313_RS17360	COG0583	DNA-binding transcription factor activity
BI313_RS17375	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BI313_RS17395	COG1028	Short-chain dehydrogenase reductase Sdr
BI313_RS17400	COG0604	alcohol dehydrogenase
BI313_RS17400	COG3321	synthase
BI313_RS17405	COG0604	alcohol dehydrogenase
BI313_RS17405	COG3321	synthase
BI313_RS17405	COG1028	Short-chain dehydrogenase reductase Sdr
BI313_RS17430	COG1733	regulation of RNA biosynthetic process
BI313_RS17435	COG0840	transmembrane signaling receptor activity
BI313_RS17505	COG0129	dihydroxy-acid dehydratase activity
BI313_RS17515	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
BI313_RS17570	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
BI313_RS17575	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BI313_RS17605	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
BI313_RS17610	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
BI313_RS17620	COG3485	protocatechuate 3,4-dioxygenase
BI313_RS17625	COG3485	protocatechuate 3,4-dioxygenase
BI313_RS17635	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BI313_RS17640	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BI313_RS17650	COG1414	Transcriptional regulator
BI313_RS17660	COG0657	acetylesterase activity
BI313_RS17670	COG0445	tRNA wobble uridine modification
BI313_RS17680	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BI313_RS17705	COG1028	Short-chain dehydrogenase reductase Sdr
BI313_RS17725	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
BI313_RS17730	COG1040	competence protein
BI313_RS17755	COG0840	transmembrane signaling receptor activity
BI313_RS17770	COG3264	Mechanosensitive ion channel
BI313_RS17770	COG1511	domain protein
BI313_RS17775	COG1368	sulfuric ester hydrolase activity
BI313_RS17785	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BI313_RS17790	COG2354	Protein conserved in bacteria
BI313_RS17800	COG0297	glycogen (starch) synthase activity
BI313_RS17810	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
BI313_RS17835	COG0702	epimerase
BI313_RS17840	COG1028	Short-chain dehydrogenase reductase Sdr
BI313_RS17875	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BI313_RS17885	COG4221	oxidoreductase activity
BI313_RS17900	COG0513	Belongs to the DEAD box helicase family
BI313_RS17915	COG0508	dehydrogenase complex catalyzes the overall conversion of
BI313_RS17930	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BI313_RS17945	COG3104	oligopeptide transport
BI313_RS17965	COG2852	Protein conserved in bacteria
BI313_RS17985	COG1320	monovalent cation:proton antiporter activity
BI313_RS17990	COG2212	antiporter activity
BI313_RS18000	COG0651	ATP synthesis coupled electron transport
BI313_RS18005	COG1006	Multisubunit Na H antiporter MnhC subunit
BI313_RS18010	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BI313_RS18010	COG2111	Na H antiporter
BI313_RS18055	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
BI313_RS18075	COG0456	acetyltransferase
BI313_RS18080	COG1597	lipid kinase activity
BI313_RS18100	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
BI313_RS18145	COG0134	indole-3-glycerol-phosphate synthase activity
BI313_RS18155	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BI313_RS18170	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
BI313_RS18180	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BI313_RS18215	COG0745	RESPONSE REGULATOR receiver
BI313_RS18235	COG0316	Belongs to the HesB IscA family
BI313_RS18240	COG2816	NAD+ diphosphatase activity
BI313_RS18245	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
BI313_RS18270	COG2814	Major facilitator Superfamily
BI313_RS18275	COG1289	transmembrane transporter activity
BI313_RS18280	COG0151	Belongs to the GarS family
BI313_RS18295	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BI313_RS18300	COG2267	carboxylic ester hydrolase activity
BI313_RS18305	COG2453	phosphatase
BI313_RS18305	COG0671	phosphoesterase, PA-phosphatase related
BI313_RS18330	COG4589	Belongs to the CDS family
BI313_RS18340	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
BI313_RS18360	COG2264	protein methyltransferase activity
BI313_RS18375	COG0439	Biotin carboxylase
BI313_RS18385	COG0511	ligase activity, forming carbon-carbon bonds
BI313_RS18390	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BI313_RS18400	COG1324	tolerance protein
BI313_RS18405	COG2356	endonuclease I
BI313_RS18415	COG0459	protein refolding
BI313_RS18435	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BI313_RS18455	COG3386	PFAM SMP-30 Gluconolaconase
BI313_RS18465	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
BI313_RS18510	COG0778	Nitroreductase
BI313_RS18515	COG2353	YceI-like domain
BI313_RS18535	COG3052	prosthetic group binding
BI313_RS18570	COG1802	Transcriptional regulator
BI313_RS18700	COG0435	Glutathione S-transferase
BI313_RS18745	COG2409	Drug exporters of the RND superfamily
BI313_RS18770	COG1959	2 iron, 2 sulfur cluster binding
BI313_RS18775	COG3634	alkyl hydroperoxide reductase activity
BI313_RS18800	COG0697	spore germination
BI313_RS18820	COG1113	amino acid transport
BI313_RS18880	COG0840	transmembrane signaling receptor activity
BI313_RS18885	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BI313_RS18885	COG5297	Belongs to the glycosyl hydrolase family 6
BI313_RS18890	COG0659	secondary active sulfate transmembrane transporter activity
BI313_RS18935	COG2943	transferase activity, transferring hexosyl groups
BI313_RS18945	COG3275	phosphorelay sensor kinase activity
BI313_RS18955	COG0181	hydroxymethylbilane synthase activity
BI313_RS18980	COG1505	serine-type exopeptidase activity
BI313_RS18995	COG0436	Aminotransferase
BI313_RS19010	COG2832	Protein of unknown function (DUF454)
BI313_RS19020	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BI313_RS19030	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
BI313_RS19040	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
BI313_RS19045	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
BI313_RS19060	COG2153	protein acetylation
BI313_RS19075	COG2226	methyltransferase
BI313_RS19080	COG5001	Diguanylate cyclase
BI313_RS19080	COG3300	MHYT domain
BI313_RS19085	COG0308	aminopeptidase N
BI313_RS19120	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
BI313_RS19130	COG3284	Transcriptional regulator
BI313_RS19135	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BI313_RS19140	COG1077	Cell shape determining protein MreB Mrl
BI313_RS19145	COG1792	Involved in formation and maintenance of cell shape
BI313_RS19160	COG0772	Belongs to the SEDS family
BI313_RS19170	COG2951	lytic endotransglycosylase activity
BI313_RS19175	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
BI313_RS19180	COG1686	Belongs to the peptidase S11 family
BI313_RS19195	COG2921	Belongs to the UPF0250 family
BI313_RS19200	COG0321	lipoyl(octanoyl) transferase activity
BI313_RS19205	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
BI313_RS19220	COG0583	DNA-binding transcription factor activity
BI313_RS19230	COG1051	belongs to the nudix hydrolase family
BI313_RS19230	COG1056	cytidyltransferase-related domain
BI313_RS19265	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
BI313_RS19270	COG0673	inositol 2-dehydrogenase activity
BI313_RS19275	COG2823	Periplasmic or secreted lipoprotein
BI313_RS19280	COG4251	negative regulation of phosphorylation
BI313_RS19285	COG0784	Response regulator, receiver
BI313_RS19290	COG4191	Histidine kinase
BI313_RS19295	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BI313_RS19300	COG1028	Short-chain dehydrogenase reductase Sdr
BI313_RS19350	COG1459	type II secretion system
BI313_RS19355	COG2165	general secretion pathway protein
BI313_RS19370	COG4795	General secretion pathway protein
BI313_RS19375	COG3156	type II secretion system protein K
BI313_RS19395	COG2188	Transcriptional regulator
BI313_RS19405	COG1609	Transcriptional regulator
BI313_RS19410	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BI313_RS19415	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BI313_RS19435	COG0617	tRNA 3'-terminal CCA addition
BI313_RS19450	COG0525	valine-tRNA ligase activity
BI313_RS19465	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BI313_RS19475	COG0795	lipopolysaccharide-transporting ATPase activity
BI313_RS19490	COG4974	Belongs to the 'phage' integrase family
BI313_RS19495	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BI313_RS19500	COG0047	phosphoribosylformylglycinamidine synthase activity
BI313_RS19500	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BI313_RS19510	COG5295	Hep Hag repeat protein
BI313_RS19515	COG1404	Belongs to the peptidase S8 family
BI313_RS19520	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BI313_RS19525	COG1459	type II secretion system
BI313_RS19530	COG2165	general secretion pathway protein
BI313_RS19535	COG4970	Tfp pilus assembly protein FimT
BI313_RS19540	COG2165	general secretion pathway protein
BI313_RS19545	COG4795	General secretion pathway protein
BI313_RS19550	COG3156	type II secretion system protein K
BI313_RS19555	COG3166	PFAM Fimbrial assembly family protein
BI313_RS19570	COG1450	Type ii and iii secretion system protein
BI313_RS19590	COG2188	Transcriptional regulator
BI313_RS19635	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
BI313_RS19650	COG1215	transferase activity, transferring glycosyl groups
BI313_RS19655	COG1215	transferase activity, transferring glycosyl groups
BI313_RS19660	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
BI313_RS19665	COG0457	Tetratricopeptide repeat
BI313_RS19685	COG0242	peptide deformylase activity
BI313_RS19690	COG0488	(ABC) transporter
BI313_RS19700	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BI313_RS19715	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BI313_RS19715	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BI313_RS19745	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BI313_RS19775	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
BI313_RS19780	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
BI313_RS19790	COG2205	protein histidine kinase activity
BI313_RS19795	COG0745	RESPONSE REGULATOR receiver
BI313_RS19800	COG4946	Tricorn protease homolog
BI313_RS19800	COG1506	peptidase
BI313_RS19800	COG0823	Involved in the tonB-independent uptake of proteins
BI313_RS19805	COG0277	FAD linked oxidase domain protein
BI313_RS19810	COG1988	membrane-bound metal-dependent
BI313_RS19815	COG0792	nuclease activity
BI313_RS19860	COG3116	cell division
BI313_RS19870	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BI313_RS19875	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BI313_RS19880	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BI313_RS19895	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BI313_RS19900	COG1181	Belongs to the D-alanine--D-alanine ligase family
BI313_RS19905	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
BI313_RS19930	COG0739	heme binding
BI313_RS19950	COG0494	nUDIX hydrolase
BI313_RS19965	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BI313_RS19975	COG1028	Short-chain dehydrogenase reductase Sdr
BI313_RS19975	COG0604	alcohol dehydrogenase
BI313_RS19975	COG3321	synthase
BI313_RS20005	COG0366	Alpha amylase catalytic
BI313_RS20035	COG2226	methyltransferase
BI313_RS20050	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
BI313_RS20070	COG2885	chlorophyll binding
BI313_RS20090	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BI313_RS20100	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BI313_RS20110	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BI313_RS20115	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BI313_RS20120	COG0667	Aldo Keto reductase
BI313_RS20130	COG4771	TonB-dependent receptor
BI313_RS20150	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BI313_RS20155	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
BI313_RS20165	COG2175	clavaminate synthase activity
BI313_RS20175	COG4181	ATPase activity
BI313_RS20190	COG0642	Histidine kinase
BI313_RS20200	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
BI313_RS20210	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
BI313_RS20220	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BI313_RS20240	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
BI313_RS20245	COG2967	ApaG domain
BI313_RS20250	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BI313_RS20255	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
BI313_RS20265	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
BI313_RS20270	COG0123	including yeast histone deacetylase and acetoin utilization protein
BI313_RS20275	COG2096	Adenosyltransferase
BI313_RS20285	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BI313_RS20290	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BI313_RS20320	COG3384	dioxygenase
BI313_RS20325	COG0583	DNA-binding transcription factor activity
BI313_RS20330	COG0318	PFAM AMP-dependent synthetase and ligase
BI313_RS20340	COG1024	Enoyl-CoA hydratase
BI313_RS20390	COG0697	spore germination
BI313_RS20395	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BI313_RS20415	COG2205	protein histidine kinase activity
BI313_RS20415	COG0784	Response regulator, receiver
BI313_RS20415	COG5002	protein histidine kinase activity
BI313_RS20420	COG2197	response regulator
BI313_RS20430	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BI313_RS20440	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BI313_RS20445	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BI313_RS20450	COG0583	DNA-binding transcription factor activity
BI313_RS20455	COG3634	alkyl hydroperoxide reductase activity
BI313_RS20465	COG2890	protein-(glutamine-N5) methyltransferase activity
BI313_RS20490	COG0778	Nitroreductase
BI313_RS20520	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
BI313_RS20545	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
BI313_RS20565	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BI313_RS20575	COG1404	Belongs to the peptidase S8 family
BI313_RS20580	COG1404	Belongs to the peptidase S8 family
BI313_RS20585	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BI313_RS20605	COG1295	ribonuclease BN
BI313_RS20610	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BI313_RS20615	COG1254	Belongs to the acylphosphatase family
BI313_RS20630	COG0521	Mo-molybdopterin cofactor biosynthetic process
BI313_RS20640	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BI313_RS20655	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
BI313_RS20660	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
BI313_RS20670	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BI313_RS20675	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
BI313_RS20680	COG0193	aminoacyl-tRNA hydrolase activity
BI313_RS20685	COG0012	GTP binding
BI313_RS20690	COG0582	viral genome integration into host DNA
BI313_RS20745	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BI313_RS20760	COG0250	Participates in transcription elongation, termination and antitermination
BI313_RS20765	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BI313_RS20770	COG0081	regulation of translation
BI313_RS20775	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BI313_RS20780	COG0222	ribosome binding
BI313_RS20790	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BI313_RS20805	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BI313_RS20810	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BI313_RS20815	COG0051	transcription antitermination factor activity, RNA binding
BI313_RS20835	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BI313_RS20855	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BI313_RS20860	COG0255	Belongs to the universal ribosomal protein uL29 family
BI313_RS20865	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BI313_RS20875	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BI313_RS20910	COG1841	ribosomal large subunit assembly
BI313_RS20915	COG0200	Binds to the 23S rRNA
BI313_RS20920	COG0201	protein transport
BI313_RS20945	COG0203	ribosomal protein L17
BI313_RS20950	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
BI313_RS20960	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
BI313_RS20970	COG0154	amidase activity
BI313_RS20980	COG1217	gtp-binding protein TYPA
BI313_RS20985	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BI313_RS20990	COG0039	L-malate dehydrogenase activity
BI313_RS20995	COG0625	glutathione transferase activity
BI313_RS21010	COG0446	pyridine nucleotide-disulphide oxidoreductase
BI313_RS21010	COG1902	pentaerythritol trinitrate reductase activity
BI313_RS21025	COG2885	chlorophyll binding
BI313_RS21050	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
BI313_RS21055	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
BI313_RS21060	COG4208	sulfate ABC transporter
BI313_RS21065	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
BI313_RS21095	COG0406	alpha-ribazole phosphatase activity
BI313_RS21105	COG0285	dihydrofolate synthase activity
BI313_RS21125	COG2833	Protein of unknown function (DUF455)
BI313_RS21130	COG3291	Pkd domain containing protein
BI313_RS21140	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BI313_RS21145	COG0671	phosphoesterase, PA-phosphatase related
BI313_RS21150	COG0438	transferase activity, transferring glycosyl groups
BI313_RS21160	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
BI313_RS21175	COG4783	chaperone-mediated protein folding
BI313_RS21190	COG0473	3-isopropylmalate dehydrogenase activity
BI313_RS21225	COG3852	Histidine kinase
BI313_RS21235	COG0544	peptidyl-prolyl cis-trans isomerase activity
BI313_RS21245	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BI313_RS21275	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BI313_RS21285	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BI313_RS21305	COG0631	protein serine/threonine phosphatase activity
BI313_RS21320	COG0859	PFAM glycosyl transferase family 9
BI313_RS21330	COG1234	tRNA 3'-trailer cleavage
BI313_RS21335	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BI313_RS21345	COG0315	cyclic pyranopterin monophosphate synthase activity
BI313_RS21350	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
BI313_RS21355	COG0314	molybdopterin synthase activity
BI313_RS21375	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
BI313_RS21385	COG0537	adenosine 5'-monophosphoramidase activity
BI313_RS21405	COG0714	Associated with various cellular activities
BI313_RS21425	COG0424	maF-like protein
BI313_RS21430	COG1399	metal-binding, possibly nucleic acid-binding protein
BI313_RS21435	COG0333	Belongs to the bacterial ribosomal protein bL32 family
BI313_RS21440	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BI313_RS21450	COG1028	Short-chain dehydrogenase reductase Sdr
BI313_RS21465	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BI313_RS21470	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BI313_RS21495	COG3829	transcription factor binding
BI313_RS21540	COG2373	Large extracellular alpha-helical protein
BI313_RS21565	COG4953	penicillin-binding protein 1C
BI313_RS21575	COG0678	peroxiredoxin activity
BI313_RS21595	COG0330	HflC and HflK could
BI313_RS21600	COG0330	HflC and HflK could
BI313_RS21605	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
BI313_RS21685	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
BI313_RS21715	COG1309	transcriptional regulator
BI313_RS21725	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BI313_RS21735	COG3387	PFAM Glycoside hydrolase 15-related
BI313_RS21740	COG1028	Short-chain dehydrogenase reductase Sdr
BI313_RS21750	COG3537	Alpha-1,2-mannosidase
BI313_RS21810	COG1064	alcohol dehydrogenase
BI313_RS21820	COG1529	Aldehyde oxidase and xanthine dehydrogenase
BI313_RS21825	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
BI313_RS21830	COG2080	2 iron, 2 sulfur cluster binding
BI313_RS21855	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BI313_RS21875	COG0587	DNA-directed DNA polymerase activity
BI313_RS21890	COG1297	OPT oligopeptide transporter protein
BI313_RS21900	COG1506	peptidase
BI313_RS21900	COG0823	Involved in the tonB-independent uptake of proteins
BI313_RS21915	COG2207	Transcriptional regulator
BI313_RS21915	COG1917	Cupin 2, conserved barrel domain protein
BI313_RS21925	COG0753	catalase activity
BI313_RS21930	COG0656	L-ascorbic acid biosynthetic process
BI313_RS21935	COG2272	Belongs to the type-B carboxylesterase lipase family
BI313_RS21940	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BI313_RS21940	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BI313_RS21945	COG2814	Major facilitator Superfamily
BI313_RS21965	COG2194	sulfuric ester hydrolase activity
BI313_RS21980	COG0745	RESPONSE REGULATOR receiver
BI313_RS21985	COG5002	protein histidine kinase activity
BI313_RS21995	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
BI313_RS22000	COG2894	cell division
BI313_RS22015	COG4585	Histidine kinase
BI313_RS22020	COG2197	response regulator
BI313_RS22035	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
BI313_RS22065	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
BI313_RS22085	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
BI313_RS22105	COG1946	Acyl-CoA thioesterase
BI313_RS22110	COG1024	Enoyl-CoA hydratase
BI313_RS22115	COG0824	Thioesterase
BI313_RS22120	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BI313_RS22130	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BI313_RS22135	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BI313_RS22140	COG0268	Binds directly to 16S ribosomal RNA
BI313_RS22145	COG0728	peptidoglycan biosynthetic process
BI313_RS22150	COG0196	riboflavin kinase activity
BI313_RS22160	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BI313_RS22165	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
BI313_RS22180	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BI313_RS22185	COG1845	cytochrome c oxidase, subunit III
BI313_RS22190	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
BI313_RS22205	COG3152	Membrane
BI313_RS22215	COG2207	Transcriptional regulator
BI313_RS22220	COG0326	Molecular chaperone. Has ATPase activity
BI313_RS22230	COG1366	Belongs to the anti-sigma-factor antagonist family
BI313_RS22235	COG1366	Belongs to the anti-sigma-factor antagonist family
BI313_RS22240	COG2172	sigma factor antagonist activity
BI313_RS22270	COG4771	TonB-dependent receptor
BI313_RS22280	COG5507	3-demethylubiquinone-9 3-methyltransferase
BI313_RS22295	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
BI313_RS22300	COG2205	protein histidine kinase activity
BI313_RS22300	COG3437	response regulator, receiver
BI313_RS22300	COG4999	Histidine kinase
BI313_RS22300	COG3850	Histidine kinase
BI313_RS22305	COG4191	Histidine kinase
BI313_RS22305	COG0784	Response regulator, receiver
BI313_RS22340	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BI313_RS22345	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BI313_RS22355	COG2070	2-Nitropropane dioxygenase
BI313_RS22375	COG0336	Belongs to the RNA methyltransferase TrmD family
BI313_RS22385	COG0534	Mate efflux family protein
BI313_RS22395	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
BI313_RS22405	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BI313_RS22410	COG0840	transmembrane signaling receptor activity
BI313_RS22430	COG3250	beta-galactosidase activity
BI313_RS22435	COG3867	Arabinogalactan endo-beta-1,4-galactanase
BI313_RS22455	COG1960	acyl-CoA dehydrogenase activity
BI313_RS22460	COG1024	Enoyl-CoA hydratase
BI313_RS22500	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BI313_RS22505	COG0481	GTPase activity
BI313_RS22535	COG1381	Involved in DNA repair and RecF pathway recombination
BI313_RS22545	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BI313_RS22555	COG2954	triphosphatase activity
BI313_RS22560	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
BI313_RS22565	COG0493	'glutamate synthase
BI313_RS22565	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
BI313_RS22570	COG3046	protein related to deoxyribodipyrimidine photolyase
BI313_RS22575	COG1472	Belongs to the glycosyl hydrolase 3 family
BI313_RS22580	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
BI313_RS22585	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
BI313_RS22590	COG1278	Cold shock
BI313_RS22595	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BI313_RS22605	COG1201	RNA secondary structure unwinding
BI313_RS22610	COG1793	dna ligase
BI313_RS22620	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
BI313_RS22620	COG1793	dna ligase
BI313_RS22650	COG0183	Belongs to the thiolase family
BI313_RS22670	COG1451	nucleotide metabolic process
BI313_RS22675	COG5487	UPF0391 membrane protein
BI313_RS22685	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BI313_RS22725	COG1047	Peptidyl-prolyl cis-trans
BI313_RS22735	COG2824	Alkylphosphonate utilization operon protein PhnA
BI313_RS22750	COG1902	pentaerythritol trinitrate reductase activity
BI313_RS22755	COG2814	Major facilitator Superfamily
BI313_RS22790	COG0392	lysyltransferase activity
BI313_RS22790	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
BI313_RS22800	COG0251	oxidation-reduction process
BI313_RS22805	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BI313_RS22820	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BI313_RS22845	COG1595	DNA-templated transcription, initiation
BI313_RS22860	COG2878	Part of a membrane complex involved in electron transport
BI313_RS22870	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BI313_RS22870	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BI313_RS22890	COG0346	lactoylglutathione lyase activity
BI313_RS22895	COG0833	amino acid
BI313_RS22900	COG2040	homocysteine
BI313_RS22915	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
BI313_RS22940	COG1695	Transcriptional regulator
BI313_RS22960	COG1981	membrane
BI313_RS22970	COG0825	malonyl-CoA metabolic process
BI313_RS22985	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BI313_RS22990	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BI313_RS23000	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BI313_RS23015	COG0750	zinc metalloprotease
BI313_RS23020	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
BI313_RS23025	COG0575	Belongs to the CDS family
BI313_RS23040	COG0528	UMP kinase activity
BI313_RS23050	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BI313_RS23095	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
BI313_RS23110	COG1393	Belongs to the ArsC family
BI313_RS23115	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BI313_RS23120	COG0367	asparagine synthase
BI313_RS23130	COG4774	siderophore transport
BI313_RS23175	COG1566	PFAM secretion protein HlyD family protein
BI313_RS23180	COG2814	Major facilitator Superfamily
BI313_RS23235	COG0339	signal peptide processing
BI313_RS23240	COG0386	Belongs to the glutathione peroxidase family
BI313_RS23310	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
BI313_RS23315	COG0084	hydrolase, TatD family'
BI313_RS23330	COG1960	acyl-CoA dehydrogenase activity
BI313_RS23345	COG0367	asparagine synthase
BI313_RS23355	COG0305	Participates in initiation and elongation during chromosome replication
BI313_RS23360	COG0415	Belongs to the DNA photolyase family
BI313_RS23375	COG0583	DNA-binding transcription factor activity
BI313_RS23390	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BI313_RS23470	COG0443	Heat shock 70 kDa protein
BI313_RS23690	COG0114	fumarate hydratase activity
BI313_RS23740	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
BI313_RS23740	COG2755	lipolytic protein G-D-S-L family
BI313_RS23795	COG1960	acyl-CoA dehydrogenase activity