locus-tag	class	description
XBW1_RS00010	COG0592	DNA-directed DNA polymerase activity
XBW1_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
XBW1_RS00020	COG0187	DNA topoisomerase II activity
XBW1_RS00040	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
XBW1_RS00075	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
XBW1_RS00085	COG0355	proton-transporting ATP synthase activity, rotational mechanism
XBW1_RS00090	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
XBW1_RS00095	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
XBW1_RS00100	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
XBW1_RS00105	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
XBW1_RS00110	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
XBW1_RS00120	COG0356	it plays a direct role in the translocation of protons across the membrane
XBW1_RS00125	COG3312	ion transport
XBW1_RS00130	COG0357	Ribosomal RNA small subunit methyltransferase G
XBW1_RS00135	COG0445	tRNA wobble uridine modification
XBW1_RS00140	COG0716	FMN binding
XBW1_RS00145	COG1522	sequence-specific DNA binding
XBW1_RS00150	COG2502	aspartate--ammonia ligase
XBW1_RS00155	COG2425	protein containing a von Willebrand factor type A (vWA) domain
XBW1_RS00160	COG0714	Associated with various cellular activities
XBW1_RS00165	COG1869	D-ribose catabolic process
XBW1_RS00170	COG1129	ABC transporter
XBW1_RS00175	COG1172	Belongs to the binding-protein-dependent transport system permease family
XBW1_RS00180	COG1879	ABC-type sugar transport system periplasmic component
XBW1_RS00185	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
XBW1_RS00190	COG1609	Transcriptional regulator
XBW1_RS00195	COG0477	Major facilitator Superfamily
XBW1_RS00220	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
XBW1_RS00225	COG3162	membrane
XBW1_RS00230	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
XBW1_RS00235	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
XBW1_RS00240	COG0180	Tryptophanyl-tRNA synthetase
XBW1_RS00245	COG0546	phosphoglycolate phosphatase activity
XBW1_RS00250	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
XBW1_RS00265	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
XBW1_RS00270	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
XBW1_RS00275	COG4796	Type ii and iii secretion system protein
XBW1_RS00295	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
XBW1_RS00310	COG0494	nUDIX hydrolase
XBW1_RS00320	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
XBW1_RS00325	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
XBW1_RS00330	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
XBW1_RS00335	COG1741	Belongs to the pirin family
XBW1_RS00340	COG1454	alcohol dehydrogenase
XBW1_RS00385	COG5433	transposase activity
XBW1_RS00420	COG1012	belongs to the aldehyde dehydrogenase family
XBW1_RS00440	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
XBW1_RS00445	COG3152	Membrane
XBW1_RS00450	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XBW1_RS00460	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
XBW1_RS00465	COG5433	transposase activity
XBW1_RS00505	COG2081	HI0933 family
XBW1_RS00510	COG0306	phosphate transporter
XBW1_RS00525	COG0589	response to stress
XBW1_RS00535	COG0742	ribosomal rna small subunit methyltransferase
XBW1_RS00555	COG0366	Alpha amylase catalytic
XBW1_RS00560	COG1263	PTS System
XBW1_RS00560	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
XBW1_RS00580	COG1671	Belongs to the UPF0178 family
XBW1_RS00595	COG3964	amidohydrolase
XBW1_RS00625	COG2213	PTS system mannitol-specific
XBW1_RS00625	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
XBW1_RS00650	COG1794	racemase activity, acting on amino acids and derivatives
XBW1_RS00655	COG1181	Belongs to the D-alanine--D-alanine ligase family
XBW1_RS00665	COG3327	negative regulation of DNA-templated transcription, initiation
XBW1_RS00670	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
XBW1_RS00675	COG0183	Belongs to the thiolase family
XBW1_RS00680	COG2050	protein possibly involved in aromatic compounds catabolism
XBW1_RS00685	COG1250	3-hydroxyacyl-CoA dehydrogenase
XBW1_RS00690	COG1024	Enoyl-CoA hydratase
XBW1_RS00695	COG1024	Enoyl-CoA hydratase
XBW1_RS00700	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
XBW1_RS00705	COG2151	metal-sulfur cluster biosynthetic enzyme
XBW1_RS00710	COG3396	Phenylacetate-CoA oxygenase
XBW1_RS00715	COG3460	Phenylacetate-CoA oxygenase
XBW1_RS00720	COG3396	Phenylacetate-CoA oxygenase
XBW1_RS00725	COG1012	belongs to the aldehyde dehydrogenase family
XBW1_RS00725	COG2030	dehydratase
XBW1_RS00750	COG0626	cystathionine gamma-synthase activity
XBW1_RS00765	COG1735	metal-dependent hydrolase with the TIM-barrel fold
XBW1_RS00770	COG3457	Alanine racemase
XBW1_RS00780	COG2188	Transcriptional regulator
XBW1_RS00790	COG3293	Transposase
XBW1_RS00865	COG0582	viral genome integration into host DNA
XBW1_RS00955	COG4104	PAAR repeat-containing protein
XBW1_RS00955	COG3209	COG3209 Rhs family protein
XBW1_RS00965	COG3209	COG3209 Rhs family protein
XBW1_RS00965	COG4104	PAAR repeat-containing protein
XBW1_RS00975	COG3501	Rhs element vgr protein
XBW1_RS01070	COG3335	DDE superfamily endonuclease
XBW1_RS01080	COG1295	ribonuclease BN
XBW1_RS01085	COG1942	4-Oxalocrotonate Tautomerase
XBW1_RS01095	COG2814	Major facilitator Superfamily
XBW1_RS01105	COG0612	Peptidase, M16
XBW1_RS01110	COG2199	diguanylate cyclase activity
XBW1_RS01110	COG2200	EAL domain
XBW1_RS01115	COG4608	Belongs to the ABC transporter superfamily
XBW1_RS01120	COG0444	Belongs to the ABC transporter superfamily
XBW1_RS01125	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
XBW1_RS01130	COG0601	transmembrane transport
XBW1_RS01135	COG0747	negative chemotaxis
XBW1_RS01145	COG0751	glycine-tRNA ligase activity
XBW1_RS01150	COG0752	glycyl-tRNA synthetase alpha subunit
XBW1_RS01155	COG2818	Glycosylase
XBW1_RS01160	COG3977	Valine--pyruvate aminotransferase
XBW1_RS01170	COG0823	Involved in the tonB-independent uptake of proteins
XBW1_RS01175	COG2860	membrane
XBW1_RS01180	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
XBW1_RS01185	COG0194	GDP metabolic process
XBW1_RS01195	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
XBW1_RS01200	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
XBW1_RS01205	COG0786	glutamate:sodium symporter activity
XBW1_RS01210	COG2233	PERMEase
XBW1_RS01215	COG2982	Protein involved in outer membrane biogenesis
XBW1_RS01220	COG0456	acetyltransferase
XBW1_RS01225	COG1490	D-aminoacyl-tRNA deacylase activity
XBW1_RS01230	COG1011	Hydrolase
XBW1_RS01325	COG2252	PERMEase
XBW1_RS01365	COG3157	Type VI secretion system effector, Hcp
XBW1_RS01370	COG0765	amino acid transport
XBW1_RS01375	COG0765	amino acid transport
XBW1_RS01380	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
XBW1_RS01390	COG0704	Plays a role in the regulation of phosphate uptake
XBW1_RS01395	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
XBW1_RS01400	COG0581	inorganic phosphate transmembrane transporter activity
XBW1_RS01405	COG0573	inorganic phosphate transmembrane transporter activity
XBW1_RS01410	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
XBW1_RS01425	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
XBW1_RS01430	COG2183	response to ionizing radiation
XBW1_RS01440	COG1918	ferrous iron import across plasma membrane
XBW1_RS01460	COG3077	Addiction module antitoxin, RelB DinJ family
XBW1_RS01470	COG0596	Alpha beta hydrolase
XBW1_RS01480	COG0316	Belongs to the HesB IscA family
XBW1_RS01480	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
XBW1_RS01485	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
XBW1_RS01490	COG0705	Rhomboid family
XBW1_RS01495	COG1349	DNA-binding transcription factor activity
XBW1_RS01500	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
XBW1_RS01510	COG2188	Transcriptional regulator
XBW1_RS01515	COG3293	Transposase
XBW1_RS01530	COG4626	Terminase
XBW1_RS01530	COG1802	Transcriptional regulator
XBW1_RS01535	COG3423	Transcriptional regulator
XBW1_RS01545	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
XBW1_RS01550	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
XBW1_RS01565	COG1070	Carbohydrate kinase
XBW1_RS01570	COG2390	Transcriptional regulator
XBW1_RS01590	COG1879	ABC-type sugar transport system periplasmic component
XBW1_RS01595	COG1830	Aldolase
XBW1_RS01600	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
XBW1_RS01625	COG1763	Mo-molybdopterin cofactor biosynthetic process
XBW1_RS01630	COG0746	molybdenum cofactor guanylyltransferase activity
XBW1_RS01635	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
XBW1_RS01645	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
XBW1_RS01645	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
XBW1_RS01650	COG0218	Necessary for normal cell division and for the maintenance of normal septation
XBW1_RS01655	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
XBW1_RS01670	COG3954	Phosphoribulokinase
XBW1_RS01675	COG3089	Belongs to the UPF0270 family
XBW1_RS01685	COG1263	PTS System
XBW1_RS01685	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
XBW1_RS01690	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
XBW1_RS01705	COG0583	DNA-binding transcription factor activity
XBW1_RS01710	COG0488	(ABC) transporter
XBW1_RS01715	COG2249	NAD(P)H dehydrogenase (quinone) activity
XBW1_RS01725	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
XBW1_RS01730	COG1047	Peptidyl-prolyl cis-trans
XBW1_RS01735	COG2900	Belongs to the SlyX family
XBW1_RS01740	COG0545	Peptidyl-prolyl cis-trans isomerase
XBW1_RS01745	COG2964	Protein conserved in bacteria
XBW1_RS01750	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
XBW1_RS01755	COG2923	Belongs to the DsrF TusC family
XBW1_RS01760	COG2168	tRNA wobble position uridine thiolation
XBW1_RS01765	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
XBW1_RS01770	COG0049	tRNA binding
XBW1_RS01775	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
XBW1_RS01790	COG0250	Participates in transcription elongation, termination and antitermination
XBW1_RS01795	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
XBW1_RS01800	COG0081	regulation of translation
XBW1_RS01805	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
XBW1_RS01810	COG0222	ribosome binding
XBW1_RS01815	COG0085	RNA polymerase activity
XBW1_RS01820	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
XBW1_RS01825	COG0726	polysaccharide deacetylase
XBW1_RS01835	COG4580	involved in the transport of maltose and maltodextrins
XBW1_RS01840	COG3842	ATPase activity
XBW1_RS01850	COG1175	transmembrane transport
XBW1_RS01855	COG3833	ABC-type maltose transport systems, permease component
XBW1_RS01860	COG1640	4-alpha-glucanotransferase
XBW1_RS01865	COG0058	SHG alpha-glucan phosphorylase activity
XBW1_RS01875	COG2909	trisaccharide binding
XBW1_RS01880	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
XBW1_RS01885	COG1064	alcohol dehydrogenase
XBW1_RS01890	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
XBW1_RS01895	COG2223	nitrite transmembrane transporter activity
XBW1_RS01910	COG2022	thiamine diphosphate biosynthetic process
XBW1_RS01915	COG2104	thiamine diphosphate biosynthetic process
XBW1_RS01920	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
XBW1_RS01925	COG0352	thiamine-phosphate diphosphorylase activity
XBW1_RS01930	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
XBW1_RS01940	COG2816	NAD+ diphosphatase activity
XBW1_RS01945	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
XBW1_RS01950	COG1515	deoxyribonuclease V activity
XBW1_RS01970	COG0151	Belongs to the GarS family
XBW1_RS01975	COG0138	bifunctional purine biosynthesis protein purh
XBW1_RS02010	COG1914	H( )-stimulated, divalent metal cation uptake system
XBW1_RS02015	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
XBW1_RS02020	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
XBW1_RS02025	COG4770	biotin carboxylase activity
XBW1_RS02040	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
XBW1_RS02050	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
XBW1_RS02055	COG1053	succinate dehydrogenase
XBW1_RS02060	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
XBW1_RS02065	COG0584	glycerophosphoryl diester phosphodiesterase
XBW1_RS02070	COG2271	Major facilitator Superfamily
XBW1_RS02085	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
XBW1_RS02090	COG0425	Belongs to the sulfur carrier protein TusA family
XBW1_RS02100	COG3776	membrane
XBW1_RS02105	COG0742	ribosomal rna small subunit methyltransferase
XBW1_RS02110	COG0552	protein localization to endoplasmic reticulum
XBW1_RS02110	COG0552	protein localization to endoplasmic reticulum
XBW1_RS02115	COG2884	Cell division ATP-binding protein ftsE
XBW1_RS02120	COG2177	Part of the ABC transporter FtsEX involved in
XBW1_RS02130	COG1929	Belongs to the glycerate kinase type-1 family
XBW1_RS02135	COG0456	acetyltransferase
XBW1_RS02155	COG3501	Rhs element vgr protein
XBW1_RS02180	COG5433	transposase activity
XBW1_RS02190	COG0559	Belongs to the binding-protein-dependent transport system permease family
XBW1_RS02205	COG0410	ABC transporter
XBW1_RS02230	COG3335	DDE superfamily endonuclease
XBW1_RS02255	COG2814	Major facilitator Superfamily
XBW1_RS02340	COG3423	Transcriptional regulator
XBW1_RS02350	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
XBW1_RS02355	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
XBW1_RS02360	COG2264	protein methyltransferase activity
XBW1_RS02365	COG4145	pantothenate transmembrane transporter activity
XBW1_RS02370	COG3924	membrane
XBW1_RS02375	COG0439	Biotin carboxylase
XBW1_RS02380	COG0511	ligase activity, forming carbon-carbon bonds
XBW1_RS02385	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
XBW1_RS02390	COG0604	alcohol dehydrogenase
XBW1_RS02395	COG1077	Cell shape determining protein MreB Mrl
XBW1_RS02400	COG1792	Involved in formation and maintenance of cell shape
XBW1_RS02405	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
XBW1_RS02410	COG0424	maF-like protein
XBW1_RS02415	COG1530	ribonuclease E activity
XBW1_RS02420	COG3164	Protein of unknown function
XBW1_RS02425	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
XBW1_RS02430	COG0312	modulator of DNA gyrase
XBW1_RS02440	COG2732	(Barnase) inhibitor
XBW1_RS02460	COG3028	Belongs to the UPF0307 family
XBW1_RS02465	COG0312	modulator of DNA gyrase
XBW1_RS02470	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
XBW1_RS02480	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
XBW1_RS02485	COG1660	Displays ATPase and GTPase activities
XBW1_RS02500	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
XBW1_RS02505	COG1137	ATPase activity
XBW1_RS02510	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
XBW1_RS02515	COG3117	lipopolysaccharide transmembrane transporter activity
XBW1_RS02520	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
XBW1_RS02525	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
XBW1_RS02525	COG0517	IMP dehydrogenase activity
XBW1_RS02530	COG0530	calcium, potassium:sodium antiporter activity
XBW1_RS02535	COG1127	ABC transporter
XBW1_RS02540	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
XBW1_RS02545	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
XBW1_RS02550	COG2854	intermembrane phospholipid transfer
XBW1_RS02560	COG5007	Belongs to the BolA IbaG family
XBW1_RS02565	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
XBW1_RS02570	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
XBW1_RS02575	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
XBW1_RS02580	COG3105	Protein conserved in bacteria
XBW1_RS02585	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
XBW1_RS02590	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
XBW1_RS02595	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
XBW1_RS02600	COG0625	glutathione transferase activity
XBW1_RS02605	COG2969	positive regulation of protein catabolic process
XBW1_RS02615	COG0493	'glutamate synthase
XBW1_RS02620	COG0067	glutamate synthase
XBW1_RS02620	COG0069	glutamate synthase activity
XBW1_RS02620	COG0070	glutamate synthase
XBW1_RS02625	COG0784	Response regulator, receiver
XBW1_RS02625	COG5002	protein histidine kinase activity
XBW1_RS02625	COG2198	Histidine kinase
XBW1_RS02630	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
XBW1_RS02635	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
XBW1_RS02640	COG2823	Periplasmic or secreted lipoprotein
XBW1_RS02645	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
XBW1_RS02650	COG0792	nuclease activity
XBW1_RS02660	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
XBW1_RS02665	COG1741	Belongs to the pirin family
XBW1_RS02670	COG0583	DNA-binding transcription factor activity
XBW1_RS02675	COG2259	Doxx family
XBW1_RS02680	COG3335	DDE superfamily endonuclease
XBW1_RS02705	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
XBW1_RS02710	COG4575	ribosome binding
XBW1_RS02715	COG0586	Pfam SNARE associated Golgi protein
XBW1_RS02720	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
XBW1_RS02725	COG0446	pyridine nucleotide-disulphide oxidoreductase
XBW1_RS02725	COG1902	pentaerythritol trinitrate reductase activity
XBW1_RS02735	COG2990	Protein conserved in bacteria
XBW1_RS02745	COG0477	Major facilitator Superfamily
XBW1_RS02750	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
XBW1_RS02755	COG1028	Short-chain dehydrogenase reductase Sdr
XBW1_RS02765	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
XBW1_RS02790	COG1216	Glycosyl transferase, family 2
XBW1_RS02795	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
XBW1_RS02810	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
XBW1_RS02815	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
XBW1_RS02860	COG2345	Transcriptional regulator
XBW1_RS02935	COG3423	Transcriptional regulator
XBW1_RS02955	COG0358	DNA primase activity
XBW1_RS02960	COG0828	Belongs to the bacterial ribosomal protein bS21 family
XBW1_RS02965	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
XBW1_RS02975	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
XBW1_RS02980	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
XBW1_RS02990	COG4991	sh3 domain protein
XBW1_RS02995	COG3025	triphosphatase activity
XBW1_RS03000	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
XBW1_RS03005	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
XBW1_RS03005	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
XBW1_RS03020	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
XBW1_RS03025	COG3384	dioxygenase
XBW1_RS03030	COG0754	glutathionylspermidine amidase activity
XBW1_RS03035	COG5463	Belongs to the UPF0441 family
XBW1_RS03040	COG1538	Outer membrane efflux protein
XBW1_RS03045	COG0494	nUDIX hydrolase
XBW1_RS03050	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
XBW1_RS03055	COG3150	esterase
XBW1_RS03065	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
XBW1_RS03070	COG0204	Acyl-transferase
XBW1_RS03075	COG2132	Multicopper oxidase
XBW1_RS03085	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
XBW1_RS03090	COG2967	ApaG domain
XBW1_RS03095	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
XBW1_RS03100	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
XBW1_RS03105	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
XBW1_RS03110	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
XBW1_RS03115	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
XBW1_RS03120	COG0564	pseudouridine synthase activity
XBW1_RS03125	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
XBW1_RS03130	COG0417	DNA replication proofreading
XBW1_RS03140	COG1804	L-carnitine dehydratase bile acid-inducible protein F
XBW1_RS03145	COG1804	L-carnitine dehydratase bile acid-inducible protein F
XBW1_RS03165	COG3335	DDE superfamily endonuclease
XBW1_RS03170	COG1028	Short-chain dehydrogenase reductase Sdr
XBW1_RS03180	COG3033	Beta-eliminating lyase
XBW1_RS03235	COG1358	cellular component organization or biogenesis
XBW1_RS03250	COG2862	Uncharacterized protein family, UPF0114
XBW1_RS03260	COG1250	3-hydroxyacyl-CoA dehydrogenase
XBW1_RS03270	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
XBW1_RS03275	COG1960	acyl-CoA dehydrogenase activity
XBW1_RS03290	COG3293	Transposase
XBW1_RS03340	COG3335	DDE superfamily endonuclease
XBW1_RS03345	COG3335	DDE superfamily endonuclease
XBW1_RS03370	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
XBW1_RS03470	COG4695	Portal protein
XBW1_RS03480	COG4626	Terminase
XBW1_RS03480	COG1802	Transcriptional regulator
XBW1_RS03520	COG2189	Belongs to the N(4) N(6)-methyltransferase family
XBW1_RS03530	COG3293	Transposase
XBW1_RS03550	COG0305	Participates in initiation and elongation during chromosome replication
XBW1_RS03555	COG1484	DNA-dependent DNA replication
XBW1_RS03630	COG3041	Addiction module toxin RelE StbE family
XBW1_RS03635	COG3077	Addiction module antitoxin, RelB DinJ family
XBW1_RS03725	COG2369	cell adhesion
XBW1_RS03730	COG3567	Phage-associated protein, HI1409 family
XBW1_RS03835	COG1484	DNA-dependent DNA replication
XBW1_RS03910	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
XBW1_RS03970	COG0582	viral genome integration into host DNA
XBW1_RS03980	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
XBW1_RS03985	COG2501	S4 domain
XBW1_RS03990	COG0215	cysteine-tRNA ligase activity
XBW1_RS03995	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
XBW1_RS04000	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XBW1_RS04005	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
XBW1_RS04010	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
XBW1_RS04015	COG0307	riboflavin synthase, alpha
XBW1_RS04030	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
XBW1_RS04035	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
XBW1_RS04040	COG4181	ATPase activity
XBW1_RS04045	COG2755	lipolytic protein G-D-S-L family
XBW1_RS04050	COG0300	oxidoreductase activity
XBW1_RS04055	COG3118	belongs to the thioredoxin family
XBW1_RS04060	COG0330	HflC and HflK could
XBW1_RS04070	COG0789	Transcriptional regulator
XBW1_RS04075	COG2217	Heavy metal translocating P-type atpase
XBW1_RS04080	COG3735	TraB family
XBW1_RS04085	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
XBW1_RS04095	COG0737	Belongs to the 5'-nucleotidase family
XBW1_RS04100	COG2223	nitrite transmembrane transporter activity
XBW1_RS04105	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
XBW1_RS04105	COG4651	solute:proton antiporter activity
XBW1_RS04110	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
XBW1_RS04115	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
XBW1_RS04120	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
XBW1_RS04125	COG0563	adenylate kinase activity
XBW1_RS04130	COG0326	Molecular chaperone. Has ATPase activity
XBW1_RS04135	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
XBW1_RS04140	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
XBW1_RS04145	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
XBW1_RS04150	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
XBW1_RS04160	COG3264	Mechanosensitive ion channel
XBW1_RS04160	COG1196	nuclear chromosome segregation
XBW1_RS04165	COG1309	transcriptional regulator
XBW1_RS04170	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XBW1_RS04175	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XBW1_RS04200	COG1946	Acyl-CoA thioesterase
XBW1_RS04205	COG0004	ammonium transporteR
XBW1_RS04210	COG0347	Belongs to the P(II) protein family
XBW1_RS04215	COG1132	(ABC) transporter
XBW1_RS04220	COG1132	(ABC) transporter
XBW1_RS04225	COG1522	sequence-specific DNA binding
XBW1_RS04235	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
XBW1_RS04240	COG0824	Thioesterase
XBW1_RS04245	COG1555	photosystem II stabilization
XBW1_RS04250	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
XBW1_RS04260	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
XBW1_RS04265	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
XBW1_RS04270	COG0740	serine-type endopeptidase activity
XBW1_RS04275	COG0544	peptidyl-prolyl cis-trans isomerase activity
XBW1_RS04285	COG0271	Belongs to the BolA IbaG family
XBW1_RS04290	COG3056	Lipoprotein
XBW1_RS04295	COG2223	nitrite transmembrane transporter activity
XBW1_RS04305	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
XBW1_RS04310	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
XBW1_RS04315	COG1845	cytochrome c oxidase, subunit III
XBW1_RS04320	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
XBW1_RS04325	COG0109	protoheme IX farnesyltransferase activity
XBW1_RS04330	COG2814	Major facilitator Superfamily
XBW1_RS04340	COG1666	GTP binding
XBW1_RS04345	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
XBW1_RS04350	COG0693	protein deglycase activity
XBW1_RS04355	COG0301	tRNA thio-modification
XBW1_RS04355	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
XBW1_RS04365	COG0142	geranyltranstransferase activity
XBW1_RS04370	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
XBW1_RS04405	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
XBW1_RS04410	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
XBW1_RS04415	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
XBW1_RS04420	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
XBW1_RS04425	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
XBW1_RS04430	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
XBW1_RS04430	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
XBW1_RS04435	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
XBW1_RS04440	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
XBW1_RS04450	COG1862	Preprotein translocase
XBW1_RS04460	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
XBW1_RS04465	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
XBW1_RS04470	COG0450	alkyl hydroperoxide reductase
XBW1_RS04485	COG5002	protein histidine kinase activity
XBW1_RS04490	COG0745	RESPONSE REGULATOR receiver
XBW1_RS04495	COG0420	3'-5' exonuclease activity
XBW1_RS04500	COG0419	ATPase involved in DNA repair
XBW1_RS04535	COG0737	Belongs to the 5'-nucleotidase family
XBW1_RS04540	COG1940	carbohydrate kinase activity
XBW1_RS04545	COG2974	May be involved in recombination
XBW1_RS04550	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
XBW1_RS04560	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
XBW1_RS04565	COG3525	Glycosyl hydrolase, family 20, catalytic domain
XBW1_RS04655	COG4626	Terminase
XBW1_RS04655	COG1802	Transcriptional regulator
XBW1_RS04670	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
XBW1_RS04685	COG0848	biopolymer transport protein
XBW1_RS04695	COG0626	cystathionine gamma-synthase activity
XBW1_RS04705	COG0656	L-ascorbic acid biosynthetic process
XBW1_RS04715	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
XBW1_RS04720	COG0505	Belongs to the CarA family
XBW1_RS04725	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
XBW1_RS04780	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
XBW1_RS04785	COG1047	Peptidyl-prolyl cis-trans
XBW1_RS04790	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
XBW1_RS04795	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
XBW1_RS04800	COG0196	riboflavin kinase activity
XBW1_RS04805	COG0268	Binds directly to 16S ribosomal RNA
XBW1_RS04810	COG0583	DNA-binding transcription factor activity
XBW1_RS04815	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
XBW1_RS04825	COG0484	heat shock protein binding
XBW1_RS04830	COG0443	Heat shock 70 kDa protein
XBW1_RS04835	COG1584	GPR1 FUN34 yaaH family protein
XBW1_RS04840	COG0477	Major facilitator Superfamily
XBW1_RS04850	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
XBW1_RS04865	COG1960	acyl-CoA dehydrogenase activity
XBW1_RS04910	COG0521	Mo-molybdopterin cofactor biosynthetic process
XBW1_RS04915	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
XBW1_RS04920	COG3022	response to hydroperoxide
XBW1_RS04930	COG0083	homoserine kinase activity
XBW1_RS04940	COG0745	RESPONSE REGULATOR receiver
XBW1_RS04945	COG3045	CreA protein
XBW1_RS04950	COG3708	Transcriptional regulator
XBW1_RS04950	COG2207	Transcriptional regulator
XBW1_RS04955	COG0406	alpha-ribazole phosphatase activity
XBW1_RS04960	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
XBW1_RS04965	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
XBW1_RS04970	COG0741	lytic transglycosylase activity
XBW1_RS04975	COG0488	(ABC) transporter
XBW1_RS04980	COG0577	efflux transmembrane transporter activity
XBW1_RS04980	COG1136	(ABC) transporter
XBW1_RS04990	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
XBW1_RS04995	COG0560	Phosphoserine phosphatase
XBW1_RS05000	COG3726	membrane protein affecting hemolysin expression
XBW1_RS05025	COG3121	Chaperone
XBW1_RS05030	COG3188	usher protein
XBW1_RS05035	COG3539	Fimbrial protein
XBW1_RS05040	COG0813	purine-nucleoside phosphorylase activity
XBW1_RS05045	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
XBW1_RS05050	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
XBW1_RS05055	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
XBW1_RS05060	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
XBW1_RS05065	COG0084	hydrolase, TatD family'
XBW1_RS05070	COG4667	esterase of the alpha-beta hydrolase superfamily
XBW1_RS05080	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
XBW1_RS05085	COG0456	acetyltransferase
XBW1_RS05090	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
XBW1_RS05095	COG2813	Specifically methylates the guanine in position
XBW1_RS05115	COG1012	belongs to the aldehyde dehydrogenase family
XBW1_RS05125	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XBW1_RS05140	COG3423	Transcriptional regulator
XBW1_RS05145	COG2076	Multidrug Resistance protein
XBW1_RS05150	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
XBW1_RS05155	COG1509	lysine 2,3-aminomutase activity
XBW1_RS05165	COG0459	protein refolding
XBW1_RS05170	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
XBW1_RS05180	COG1027	Aspartate ammonia-lyase
XBW1_RS05185	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
XBW1_RS05190	COG4232	protein-disulfide reductase activity
XBW1_RS05195	COG1309	transcriptional regulator
XBW1_RS05205	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
XBW1_RS05255	COG3547	Transposase (IS116 IS110 IS902 family)
XBW1_RS05270	COG3293	Transposase
XBW1_RS05330	COG3209	COG3209 Rhs family protein
XBW1_RS05440	COG3423	Transcriptional regulator
XBW1_RS05450	COG3335	DDE superfamily endonuclease
XBW1_RS05495	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
XBW1_RS05540	COG0582	viral genome integration into host DNA
XBW1_RS05590	COG3501	Rhs element vgr protein
XBW1_RS05600	COG3423	Transcriptional regulator
XBW1_RS05650	COG1074	ATP-dependent DNA helicase activity
XBW1_RS05660	COG1074	ATP-dependent DNA helicase activity
XBW1_RS05675	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
XBW1_RS05740	COG3675	Pfam Lipase (class 3)
XBW1_RS05760	COG1662	PFAM IS1 transposase
XBW1_RS05770	COG3335	DDE superfamily endonuclease
XBW1_RS05885	COG3423	Transcriptional regulator
XBW1_RS05915	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
XBW1_RS06005	COG0464	growth
XBW1_RS06020	COG3293	Transposase
XBW1_RS06050	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
XBW1_RS06060	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
XBW1_RS06080	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
XBW1_RS06155	COG2249	NAD(P)H dehydrogenase (quinone) activity
XBW1_RS06190	COG3423	Transcriptional regulator
XBW1_RS06195	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
XBW1_RS06220	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
XBW1_RS06275	COG3335	DDE superfamily endonuclease
XBW1_RS06295	COG3335	DDE superfamily endonuclease
XBW1_RS06310	COG5301	cellulose 1,4-beta-cellobiosidase activity
XBW1_RS06315	COG2304	oxidoreductase activity
XBW1_RS06345	COG1136	(ABC) transporter
XBW1_RS06355	COG1262	PFAM Formylglycine-generating sulfatase enzyme
XBW1_RS06385	COG1388	LysM domain
XBW1_RS06385	COG0741	lytic transglycosylase activity
XBW1_RS06390	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
XBW1_RS06395	COG2226	methyltransferase
XBW1_RS06430	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
XBW1_RS06435	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
XBW1_RS06470	COG3501	Rhs element vgr protein
XBW1_RS06480	COG3335	DDE superfamily endonuclease
XBW1_RS06485	COG2368	4-hydroxyphenylacetate
XBW1_RS06490	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
XBW1_RS06495	COG3104	oligopeptide transport
XBW1_RS06500	COG2271	Major facilitator Superfamily
XBW1_RS06510	COG2197	response regulator
XBW1_RS06530	COG3501	Rhs element vgr protein
XBW1_RS06575	COG3971	2-oxopent-4-enoate hydratase activity
XBW1_RS06590	COG3384	dioxygenase
XBW1_RS06595	COG1012	belongs to the aldehyde dehydrogenase family
XBW1_RS06605	COG0179	Fumarylacetoacetate (FAA) hydrolase
XBW1_RS06610	COG1846	Transcriptional regulator
XBW1_RS06625	COG2226	methyltransferase
XBW1_RS06625	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
XBW1_RS06625	COG3433	isochorismatase activity
XBW1_RS06630	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
XBW1_RS06630	COG2226	methyltransferase
XBW1_RS06630	COG3433	isochorismatase activity
XBW1_RS06655	COG1132	(ABC) transporter
XBW1_RS06655	COG2375	cellular response to nickel ion
XBW1_RS06660	COG1132	(ABC) transporter
XBW1_RS06670	COG4592	Periplasmic binding protein
XBW1_RS06680	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
XBW1_RS06685	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
XBW1_RS06690	COG1120	ATPase activity
XBW1_RS06700	COG3251	PFAM MbtH domain protein
XBW1_RS06705	COG2382	esterase
XBW1_RS06710	COG4774	siderophore transport
XBW1_RS06715	COG1169	isochorismate synthase
XBW1_RS06720	COG1021	2,3-dihydroxybenzoate-AMP ligase
XBW1_RS06725	COG1535	isochorismatase
XBW1_RS06725	COG3433	isochorismatase activity
XBW1_RS06730	COG1028	Short-chain dehydrogenase reductase Sdr
XBW1_RS06735	COG2814	Major facilitator Superfamily
XBW1_RS06750	COG2814	Major facilitator Superfamily
XBW1_RS06760	COG3962	Belongs to the TPP enzyme family
XBW1_RS06765	COG0673	inositol 2-dehydrogenase activity
XBW1_RS06770	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
XBW1_RS06775	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
XBW1_RS06785	COG3718	enzyme involved in inositol metabolism
XBW1_RS06810	COG1309	transcriptional regulator
XBW1_RS06825	COG3077	Addiction module antitoxin, RelB DinJ family
XBW1_RS06935	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
XBW1_RS06940	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
XBW1_RS06940	COG1648	precorrin-2 dehydrogenase activity
XBW1_RS06950	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
XBW1_RS06960	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
XBW1_RS07025	COG1492	cobalamin metabolic process
XBW1_RS07030	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
XBW1_RS07045	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
XBW1_RS07050	COG0318	PFAM AMP-dependent synthetase and ligase
XBW1_RS07055	COG1028	Short-chain dehydrogenase reductase Sdr
XBW1_RS07060	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
XBW1_RS07115	COG3772	lysozyme
XBW1_RS07180	COG1216	Glycosyl transferase, family 2
XBW1_RS07185	COG0463	Glycosyl transferase, family 2
XBW1_RS07240	COG2841	Protein conserved in bacteria
XBW1_RS07255	COG0740	serine-type endopeptidase activity
XBW1_RS07280	COG3038	cytochrome b561
XBW1_RS07290	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
XBW1_RS07300	COG0372	Belongs to the citrate synthase family
XBW1_RS07325	COG3293	Transposase
XBW1_RS07345	COG5433	transposase activity
XBW1_RS07350	COG0582	viral genome integration into host DNA
XBW1_RS07355	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
XBW1_RS07360	COG2867	negative regulation of translational initiation
XBW1_RS07365	COG2914	Belongs to the UPF0125 (RnfH) family
XBW1_RS07370	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XBW1_RS07375	COG0497	DNA recombination
XBW1_RS07380	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
XBW1_RS07385	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
XBW1_RS07390	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
XBW1_RS07400	COG0513	Belongs to the DEAD box helicase family
XBW1_RS07440	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
XBW1_RS07445	COG0736	holo-[acyl-carrier-protein] synthase activity
XBW1_RS07450	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
XBW1_RS07455	COG1381	Involved in DNA repair and RecF pathway recombination
XBW1_RS07460	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
XBW1_RS07465	COG0571	ribonuclease III activity
XBW1_RS07470	COG0681	Belongs to the peptidase S26 family
XBW1_RS07475	COG0481	GTPase activity
XBW1_RS07480	COG3086	response to oxidative stress
XBW1_RS07495	COG1595	DNA-templated transcription, initiation
XBW1_RS07500	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
XBW1_RS07750	COG0484	heat shock protein binding
XBW1_RS07870	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
XBW1_RS07875	COG1418	mRNA catabolic process
XBW1_RS07890	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
XBW1_RS07895	COG0047	phosphoribosylformylglycinamidine synthase activity
XBW1_RS07895	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
XBW1_RS07900	COG2205	protein histidine kinase activity
XBW1_RS07905	COG3170	Tfp pilus assembly protein FimV
XBW1_RS07910	COG2204	response regulator
XBW1_RS07915	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
XBW1_RS07915	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
XBW1_RS07920	COG0347	Belongs to the P(II) protein family
XBW1_RS07925	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
XBW1_RS07925	COG1017	nitric oxide dioxygenase activity
XBW1_RS07950	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
XBW1_RS07955	COG2814	Major facilitator Superfamily
XBW1_RS07965	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
XBW1_RS07970	COG1959	2 iron, 2 sulfur cluster binding
XBW1_RS07975	COG1104	cysteine desulfurase activity
XBW1_RS07980	COG0822	iron-sulfur transferase activity
XBW1_RS07985	COG0316	Belongs to the HesB IscA family
XBW1_RS07990	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
XBW1_RS07995	COG0443	Heat shock 70 kDa protein
XBW1_RS08000	COG0633	Ferredoxin
XBW1_RS08005	COG2975	iron-sulfur cluster assembly
XBW1_RS08010	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
XBW1_RS08020	COG2373	Large extracellular alpha-helical protein
XBW1_RS08025	COG4953	penicillin-binding protein 1C
XBW1_RS08035	COG3655	Transcriptional regulator
XBW1_RS08045	COG0105	UTP biosynthetic process
XBW1_RS08050	COG0820	rRNA (adenine-C2-)-methyltransferase activity
XBW1_RS08060	COG1426	Protein conserved in bacteria
XBW1_RS08065	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
XBW1_RS08070	COG0124	histidyl-tRNA synthetase
XBW1_RS08075	COG2976	Protein conserved in bacteria
XBW1_RS08080	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XBW1_RS08085	COG1160	GTP binding
XBW1_RS08105	COG0408	coproporphyrinogen oxidase activity
XBW1_RS08110	COG0456	acetyltransferase
XBW1_RS08130	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
XBW1_RS08135	COG4208	sulfate ABC transporter
XBW1_RS08140	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
XBW1_RS08150	COG2190	(PTS) system
XBW1_RS08160	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
XBW1_RS08175	COG3115	cell septum assembly
XBW1_RS08180	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
XBW1_RS08185	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
XBW1_RS08190	COG3530	Putative quorum-sensing-regulated virulence factor
XBW1_RS08200	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
XBW1_RS08235	COG0727	PFAM Uncharacterised protein family (UPF0153)
XBW1_RS08250	COG0859	PFAM glycosyl transferase family 9
XBW1_RS08260	COG0582	viral genome integration into host DNA
XBW1_RS08270	COG0582	viral genome integration into host DNA
XBW1_RS08290	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
XBW1_RS08375	COG3691	Protein conserved in bacteria
XBW1_RS08380	COG0183	Belongs to the thiolase family
XBW1_RS08385	COG1024	Enoyl-CoA hydratase
XBW1_RS08385	COG1250	3-hydroxyacyl-CoA dehydrogenase
XBW1_RS08390	COG2062	phosphohistidine phosphatase, SixA
XBW1_RS08395	COG0582	viral genome integration into host DNA
XBW1_RS08440	COG5433	transposase activity
XBW1_RS08445	COG0484	heat shock protein binding
XBW1_RS08465	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
XBW1_RS08485	COG0579	oxidoreductase
XBW1_RS08495	COG5433	transposase activity
XBW1_RS08535	COG2249	NAD(P)H dehydrogenase (quinone) activity
XBW1_RS08540	COG2207	Transcriptional regulator
XBW1_RS08550	COG0012	GTP binding
XBW1_RS08555	COG0193	aminoacyl-tRNA hydrolase activity
XBW1_RS08570	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
XBW1_RS08575	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
XBW1_RS08580	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
XBW1_RS08585	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
XBW1_RS08590	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
XBW1_RS08595	COG2890	protein-(glutamine-N5) methyltransferase activity
XBW1_RS08605	COG2877	3-deoxy-8-phosphooctulonate synthase activity
XBW1_RS08610	COG0659	secondary active sulfate transmembrane transporter activity
XBW1_RS08620	COG2453	phosphatase
XBW1_RS08620	COG0671	phosphoesterase, PA-phosphatase related
XBW1_RS08625	COG2267	carboxylic ester hydrolase activity
XBW1_RS08630	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
XBW1_RS08635	COG2378	regulation of single-species biofilm formation
XBW1_RS08650	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
XBW1_RS08655	COG3381	protein complex oligomerization
XBW1_RS08665	COG0477	Major facilitator Superfamily
XBW1_RS08670	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
XBW1_RS08685	COG0018	arginyl-trna synthetase
XBW1_RS08690	COG3102	Protein conserved in bacteria
XBW1_RS08695	COG3142	Participates in the control of copper homeostasis
XBW1_RS08700	COG0500	methyltransferase
XBW1_RS08705	COG2226	methyltransferase
XBW1_RS08710	COG3788	relative of glutathione S-transferase, MAPEG superfamily
XBW1_RS08715	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
XBW1_RS08720	COG0494	nUDIX hydrolase
XBW1_RS08725	COG0217	transcriptional regulatory protein
XBW1_RS08730	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
XBW1_RS08735	COG0632	four-way junction helicase activity
XBW1_RS08740	COG2255	four-way junction helicase activity
XBW1_RS08750	COG2184	nucleotidyltransferase activity
XBW1_RS08755	COG1108	ABC-type Mn2 Zn2 transport systems permease components
XBW1_RS08760	COG1121	(ABC) transporter
XBW1_RS08765	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
XBW1_RS08770	COG0739	heme binding
XBW1_RS08775	COG1560	Kdo2-lipid A biosynthetic process
XBW1_RS08780	COG0469	pyruvate kinase activity
XBW1_RS08785	COG1737	Transcriptional regulator
XBW1_RS08790	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
XBW1_RS08795	COG2076	Multidrug Resistance protein
XBW1_RS08800	COG2076	Multidrug Resistance protein
XBW1_RS08805	COG0251	oxidation-reduction process
XBW1_RS08810	COG1199	ATP-dependent helicase activity
XBW1_RS08820	COG3065	identical protein binding
XBW1_RS08830	COG0318	PFAM AMP-dependent synthetase and ligase
XBW1_RS08835	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
XBW1_RS08855	COG3293	Transposase
XBW1_RS08955	COG3047	cAMP biosynthetic process
XBW1_RS08970	COG0159	tryptophan synthase activity
XBW1_RS08975	COG0133	tryptophan synthase activity
XBW1_RS08985	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
XBW1_RS09000	COG3293	Transposase
XBW1_RS09010	COG3335	DDE superfamily endonuclease
XBW1_RS09025	COG3293	Transposase
XBW1_RS09060	COG0009	L-threonylcarbamoyladenylate synthase
XBW1_RS09070	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
XBW1_RS09075	COG1028	Short-chain dehydrogenase reductase Sdr
XBW1_RS09080	COG0616	signal peptide processing
XBW1_RS09115	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
XBW1_RS09120	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
XBW1_RS09125	COG0284	orotidine-5'-phosphate decarboxylase activity
XBW1_RS09130	COG0023	Translation Initiation Factor
XBW1_RS09175	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
XBW1_RS09180	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
XBW1_RS09190	COG4659	FMN binding
XBW1_RS09210	COG4657	Part of a membrane complex involved in electron transport
XBW1_RS09220	COG0673	inositol 2-dehydrogenase activity
XBW1_RS09225	COG0385	Bile acid
XBW1_RS09230	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
XBW1_RS09235	COG5339	Protein conserved in bacteria
XBW1_RS09240	COG1482	cell wall glycoprotein biosynthetic process
XBW1_RS09245	COG0114	fumarate hydratase activity
XBW1_RS09260	COG2814	Major facilitator Superfamily
XBW1_RS09265	COG0583	DNA-binding transcription factor activity
XBW1_RS09270	COG1940	carbohydrate kinase activity
XBW1_RS09275	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
XBW1_RS09290	COG4221	oxidoreductase activity
XBW1_RS09305	COG0456	acetyltransferase
XBW1_RS09305	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
XBW1_RS09310	COG2801	Transposase and inactivated derivatives
XBW1_RS09390	COG2814	Major facilitator Superfamily
XBW1_RS09395	COG0697	spore germination
XBW1_RS09430	COG1846	Transcriptional regulator
XBW1_RS09465	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XBW1_RS09470	COG0625	glutathione transferase activity
XBW1_RS09485	COG2271	Major facilitator Superfamily
XBW1_RS09495	COG2814	Major facilitator Superfamily
XBW1_RS09510	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
XBW1_RS09515	COG0589	response to stress
XBW1_RS09520	COG4974	Belongs to the 'phage' integrase family
XBW1_RS09540	COG3335	DDE superfamily endonuclease
XBW1_RS09550	COG5433	transposase activity
XBW1_RS09570	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
XBW1_RS09575	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
XBW1_RS09585	COG0531	amino acid
XBW1_RS09595	COG3121	Chaperone
XBW1_RS09615	COG1643	Atp-dependent helicase
XBW1_RS09620	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
XBW1_RS09625	COG3784	Protein of unknown function (DUF1318)
XBW1_RS09630	COG5433	transposase activity
XBW1_RS09635	COG2911	Protein conserved in bacteria
XBW1_RS09640	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
XBW1_RS09655	COG3335	DDE superfamily endonuclease
XBW1_RS09665	COG2983	Belongs to the UPF0260 family
XBW1_RS09670	COG0179	Fumarylacetoacetate (FAA) hydrolase
XBW1_RS09675	COG2951	lytic endotransglycosylase activity
XBW1_RS09680	COG3100	YcgL domain-containing protein
XBW1_RS09685	COG0850	regulation of cytokinetic process
XBW1_RS09690	COG2894	cell division
XBW1_RS09695	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
XBW1_RS09705	COG5433	transposase activity
XBW1_RS09755	COG3469	chitinase activity
XBW1_RS09765	COG1073	alpha beta
XBW1_RS09765	COG3064	Membrane
XBW1_RS09765	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
XBW1_RS09785	COG2917	probably involved in intracellular septation
XBW1_RS09795	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
XBW1_RS09815	COG0444	Belongs to the ABC transporter superfamily
XBW1_RS09820	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
XBW1_RS09825	COG0601	transmembrane transport
XBW1_RS09840	COG2095	MarC family integral membrane protein
XBW1_RS09845	COG1012	belongs to the aldehyde dehydrogenase family
XBW1_RS09845	COG1454	alcohol dehydrogenase
XBW1_RS09850	COG1435	thymidine kinase activity
XBW1_RS09870	COG1210	Utp--glucose-1-phosphate uridylyltransferase
XBW1_RS09875	COG0745	RESPONSE REGULATOR receiver
XBW1_RS09880	COG3012	SEC-C Motif Domain Protein
XBW1_RS09885	COG0788	formyltetrahydrofolate deformylase activity
XBW1_RS09900	COG0708	Exodeoxyribonuclease III
XBW1_RS09905	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
XBW1_RS09910	COG0709	Synthesizes selenophosphate from selenide and ATP
XBW1_RS09915	COG0778	Nitroreductase
XBW1_RS09920	COG0616	signal peptide processing
XBW1_RS09925	COG0252	asparaginase activity
XBW1_RS09930	COG1335	isochorismatase
XBW1_RS09935	COG3139	Protein of unknown function (DUF1315)
XBW1_RS09940	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
XBW1_RS09955	COG3713	MltA-interacting MipA family protein
XBW1_RS09960	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
XBW1_RS09965	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XBW1_RS09970	COG3293	Transposase
XBW1_RS09975	COG2186	Transcriptional regulator
XBW1_RS09980	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
XBW1_RS09985	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
XBW1_RS10050	COG3501	Rhs element vgr protein
XBW1_RS10075	COG3335	DDE superfamily endonuclease
XBW1_RS10100	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
XBW1_RS10105	COG1271	oxidase subunit
XBW1_RS10110	COG1294	oxidase, subunit
XBW1_RS10115	COG3850	Histidine kinase
XBW1_RS10120	COG1702	phosphate starvation-inducible protein PhoH
XBW1_RS10125	COG2356	endonuclease I
XBW1_RS10135	COG0589	response to stress
XBW1_RS10140	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
XBW1_RS10145	COG2313	pseudouridylate synthase activity
XBW1_RS10150	COG1522	sequence-specific DNA binding
XBW1_RS10150	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
XBW1_RS10155	COG0531	amino acid
XBW1_RS10160	COG1982	Orn Lys Arg decarboxylase major
XBW1_RS10165	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
XBW1_RS10165	COG2169	Transcriptional regulator
XBW1_RS10170	COG0657	acetylesterase activity
XBW1_RS10175	COG2264	protein methyltransferase activity
XBW1_RS10300	COG3335	DDE superfamily endonuclease
XBW1_RS10395	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
XBW1_RS10400	COG1988	membrane-bound metal-dependent
XBW1_RS10405	COG1823	symporter activity
XBW1_RS10410	COG0501	Belongs to the peptidase M48B family
XBW1_RS10420	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
XBW1_RS10425	COG1956	GAF domain-containing protein
XBW1_RS10435	COG1276	copper resistance
XBW1_RS10440	COG2372	response to copper ion
XBW1_RS10445	COG1528	Iron-storage protein
XBW1_RS10465	COG3140	Belongs to the UPF0181 family
XBW1_RS10475	COG0494	nUDIX hydrolase
XBW1_RS10480	COG1760	l-serine dehydratase
XBW1_RS10485	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
XBW1_RS10485	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
XBW1_RS10490	COG3715	PTS system
XBW1_RS10495	COG3716	PTS system mannose fructose sorbose family IID component
XBW1_RS10500	COG4811	Protein of unknown function (DUF986)
XBW1_RS10505	COG1971	Probably functions as a manganese efflux pump
XBW1_RS10510	COG2226	methyltransferase
XBW1_RS10525	COG0519	Catalyzes the synthesis of GMP from XMP
XBW1_RS10525	COG0518	GMP synthase (glutamine-hydrolyzing) activity
XBW1_RS10530	COG0516	GMP reductase activity
XBW1_RS10530	COG0517	IMP dehydrogenase activity
XBW1_RS10535	COG1570	exodeoxyribonuclease VII activity
XBW1_RS10540	COG4206	TonB-dependent receptor
XBW1_RS10540	COG1629	transport
XBW1_RS10545	COG1770	oligopeptidase
XBW1_RS10565	COG2197	response regulator
XBW1_RS10570	COG1393	Belongs to the ArsC family
XBW1_RS10575	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
XBW1_RS10580	COG1876	peptidase activity
XBW1_RS10585	COG1444	tRNA N-acetyltransferase activity
XBW1_RS10590	COG2707	UPF0756 membrane protein
XBW1_RS10600	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
XBW1_RS10605	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
XBW1_RS10610	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
XBW1_RS10615	COG2716	regulation of RNA biosynthetic process
XBW1_RS10620	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
XBW1_RS10625	COG0628	permease
XBW1_RS10630	COG4783	chaperone-mediated protein folding
XBW1_RS10635	COG1393	Belongs to the ArsC family
XBW1_RS10640	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
XBW1_RS10645	COG2233	PERMEase
XBW1_RS10650	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
XBW1_RS10655	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
XBW1_RS10660	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
XBW1_RS10665	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
XBW1_RS10670	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
XBW1_RS10680	COG2239	Acts as a magnesium transporter
XBW1_RS10690	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XBW1_RS10695	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XBW1_RS10700	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XBW1_RS10705	COG2205	protein histidine kinase activity
XBW1_RS10710	COG0745	RESPONSE REGULATOR receiver
XBW1_RS10715	COG0826	peptidase U32
XBW1_RS10720	COG1830	Aldolase
XBW1_RS10725	COG0351	phosphomethylpyrimidine kinase
XBW1_RS10740	COG0582	viral genome integration into host DNA
XBW1_RS10815	COG1113	amino acid transport
XBW1_RS10820	COG2207	Transcriptional regulator
XBW1_RS10825	COG3023	N-Acetylmuramoyl-L-alanine amidase
XBW1_RS10830	COG1115	amino acid carrier protein
XBW1_RS10850	COG1690	Belongs to the RtcB family
XBW1_RS10860	COG3335	DDE superfamily endonuclease
XBW1_RS10865	COG0814	amino acid
XBW1_RS10875	COG0538	isocitrate dehydrogenase activity
XBW1_RS10880	COG1187	pseudouridine synthase activity
XBW1_RS10890	COG0482	sulfurtransferase activity
XBW1_RS10895	COG2915	High frequency lysogenization protein hflD homolog
XBW1_RS10900	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
XBW1_RS10905	COG0745	RESPONSE REGULATOR receiver
XBW1_RS10910	COG2205	protein histidine kinase activity
XBW1_RS10915	COG2850	peptidyl-arginine hydroxylation
XBW1_RS10930	COG4591	ABC-type transport system involved in lipoprotein release permease component
XBW1_RS10935	COG1136	(ABC) transporter
XBW1_RS10940	COG4591	ABC-type transport system involved in lipoprotein release permease component
XBW1_RS10950	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
XBW1_RS10960	COG3335	DDE superfamily endonuclease
XBW1_RS10965	COG1252	NADH dehydrogenase
XBW1_RS10970	COG1472	Belongs to the glycosyl hydrolase 3 family
XBW1_RS10980	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
XBW1_RS10985	COG0537	adenosine 5'-monophosphoramidase activity
XBW1_RS10990	COG0084	hydrolase, TatD family'
XBW1_RS10995	COG0470	DNA polymerase III
XBW1_RS11000	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
XBW1_RS11005	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
XBW1_RS11010	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
XBW1_RS11015	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
XBW1_RS11020	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
XBW1_RS11030	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
XBW1_RS11035	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
XBW1_RS11040	COG0416	fatty acid biosynthetic process
XBW1_RS11045	COG0333	Belongs to the bacterial ribosomal protein bL32 family
XBW1_RS11050	COG1399	metal-binding, possibly nucleic acid-binding protein
XBW1_RS11055	COG0424	maF-like protein
XBW1_RS11060	COG0564	pseudouridine synthase activity
XBW1_RS11065	COG1530	ribonuclease E activity
XBW1_RS11080	COG2926	Belongs to the UPF0265 family
XBW1_RS11085	COG2925	Exonuclease
XBW1_RS11090	COG0277	FAD linked oxidase domain protein
XBW1_RS11095	COG0531	amino acid
XBW1_RS11100	COG4771	TonB-dependent receptor
XBW1_RS11105	COG1120	ATPase activity
XBW1_RS11110	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
XBW1_RS11120	COG0833	amino acid
XBW1_RS11125	COG0583	DNA-binding transcription factor activity
XBW1_RS11130	COG2855	membrane
XBW1_RS11135	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
XBW1_RS11140	COG1105	Belongs to the carbohydrate kinase PfkB family
XBW1_RS11145	COG0494	nUDIX hydrolase
XBW1_RS11155	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
XBW1_RS11170	COG0671	phosphoesterase, PA-phosphatase related
XBW1_RS11175	COG0791	NLP P60 protein
XBW1_RS11185	COG2814	Major facilitator Superfamily
XBW1_RS11190	COG1187	pseudouridine synthase activity
XBW1_RS11195	COG1061	Type III restriction enzyme res subunit
XBW1_RS11200	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
XBW1_RS11205	COG3081	Nucleoid-associated protein
XBW1_RS11210	COG3082	Protein of unknown function (DUF1414)
XBW1_RS11235	COG5433	transposase activity
XBW1_RS11245	COG3335	DDE superfamily endonuclease
XBW1_RS11290	COG1250	3-hydroxyacyl-CoA dehydrogenase
XBW1_RS11320	COG4615	Cyclic peptide transporter
XBW1_RS11325	COG0604	alcohol dehydrogenase
XBW1_RS11325	COG1028	Short-chain dehydrogenase reductase Sdr
XBW1_RS11325	COG3321	synthase
XBW1_RS11335	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
XBW1_RS11350	COG1960	acyl-CoA dehydrogenase activity
XBW1_RS11365	COG2431	L-lysine efflux transmembrane transporter activity
XBW1_RS11375	COG1677	Flagellar hook-basal body complex protein FliE
XBW1_RS11380	COG1766	The M ring may be actively involved in energy transduction
XBW1_RS11385	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
XBW1_RS11395	COG1157	protein secretion by the type III secretion system
XBW1_RS11405	COG3144	bacterial-type flagellum assembly
XBW1_RS11410	COG1580	Controls the rotational direction of flagella during chemotaxis
XBW1_RS11445	COG1028	Short-chain dehydrogenase reductase Sdr
XBW1_RS11470	COG5433	transposase activity
XBW1_RS11505	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
XBW1_RS11520	COG1706	bacterial-type flagellum-dependent cell motility
XBW1_RS11525	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
XBW1_RS11550	COG1558	bacterial-type flagellum-dependent cell motility
XBW1_RS11555	COG1815	bacterial-type flagellum-dependent cell motility
XBW1_RS11575	COG3539	Fimbrial protein
XBW1_RS11585	COG3121	Chaperone
XBW1_RS11600	COG1662	PFAM IS1 transposase
XBW1_RS11615	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
XBW1_RS11635	COG1115	amino acid carrier protein
XBW1_RS11685	COG2194	sulfuric ester hydrolase activity
XBW1_RS11700	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
XBW1_RS11705	COG0745	RESPONSE REGULATOR receiver
XBW1_RS11710	COG2201	protein-glutamate methylesterase activity
XBW1_RS11715	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
XBW1_RS11720	COG0840	transmembrane signaling receptor activity
XBW1_RS11725	COG0840	transmembrane signaling receptor activity
XBW1_RS11730	COG0835	chemotaxis
XBW1_RS11735	COG0643	Histidine kinase
XBW1_RS11735	COG2198	Histidine kinase
XBW1_RS11740	COG1360	Flagellar Motor Protein
XBW1_RS11765	COG1285	pathogenesis
XBW1_RS11815	COG0418	dihydroorotase activity
XBW1_RS11830	COG1054	Belongs to the UPF0176 family
XBW1_RS11835	COG1560	Kdo2-lipid A biosynthetic process
XBW1_RS11930	COG1802	Transcriptional regulator
XBW1_RS11930	COG4626	Terminase
XBW1_RS11955	COG1304	FMN binding
XBW1_RS11960	COG1620	l-lactate permease
XBW1_RS11975	COG3545	Serine hydrolase
XBW1_RS12025	COG1278	Cold shock
XBW1_RS12030	COG3604	Transcriptional regulator
XBW1_RS12055	COG2144	transferase activity, transferring acyl groups
XBW1_RS12065	COG2072	flavoprotein involved in K transport
XBW1_RS12070	COG3397	chitin binding
XBW1_RS12075	COG0346	lactoylglutathione lyase activity
XBW1_RS12120	COG3293	Transposase
XBW1_RS12130	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
XBW1_RS12135	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
XBW1_RS12140	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
XBW1_RS12145	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
XBW1_RS12155	COG0784	Response regulator, receiver
XBW1_RS12155	COG2205	protein histidine kinase activity
XBW1_RS12160	COG2197	response regulator
XBW1_RS12165	COG0642	Histidine kinase
XBW1_RS12165	COG2198	Histidine kinase
XBW1_RS12180	COG0814	amino acid
XBW1_RS12195	COG1441	menaquinone biosynthetic process
XBW1_RS12200	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
XBW1_RS12205	COG0596	Alpha beta hydrolase
XBW1_RS12210	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
XBW1_RS12230	COG5433	transposase activity
XBW1_RS12240	COG3121	Chaperone
XBW1_RS12250	COG3293	Transposase
XBW1_RS12265	COG3739	integral membrane protein
XBW1_RS12270	COG0483	inositol monophosphate 1-phosphatase activity
XBW1_RS12275	COG1187	pseudouridine synthase activity
XBW1_RS12305	COG1802	Transcriptional regulator
XBW1_RS12305	COG4626	Terminase
XBW1_RS12405	COG0582	viral genome integration into host DNA
XBW1_RS12540	COG5484	DNA packaging
XBW1_RS12540	COG3728	DNA packaging
XBW1_RS12595	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
XBW1_RS12705	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
XBW1_RS12710	COG0322	excinuclease ABC activity
XBW1_RS12715	COG2197	response regulator
XBW1_RS12745	COG5433	transposase activity
XBW1_RS12770	COG0583	DNA-binding transcription factor activity
XBW1_RS12785	COG1113	amino acid transport
XBW1_RS12825	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
XBW1_RS12830	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
XBW1_RS12830	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
XBW1_RS12830	COG0506	proline dehydrogenase activity
XBW1_RS12840	COG1191	sigma factor activity
XBW1_RS12950	COG5433	transposase activity
XBW1_RS12985	COG2076	Multidrug Resistance protein
XBW1_RS12990	COG0037	tRNA processing
XBW1_RS12995	COG0598	Magnesium transport protein CorA
XBW1_RS13000	COG4166	transmembrane transport
XBW1_RS13005	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
XBW1_RS13020	COG3768	UPF0283 membrane protein
XBW1_RS13025	COG3106	COG3106 Predicted ATPase
XBW1_RS13030	COG1983	PspC domain protein
XBW1_RS13040	COG1842	Phage shock protein A
XBW1_RS13045	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
XBW1_RS13050	COG4166	transmembrane transport
XBW1_RS13060	COG4171	peptide transport system, permease
XBW1_RS13085	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
XBW1_RS13090	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
XBW1_RS13095	COG0259	pyridoxamine-phosphate oxidase activity
XBW1_RS13100	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
XBW1_RS13105	COG3133	Outer membrane lipoprotein
XBW1_RS13120	COG0346	lactoylglutathione lyase activity
XBW1_RS13125	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
XBW1_RS13130	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
XBW1_RS13140	COG3293	Transposase
XBW1_RS13145	COG1609	Transcriptional regulator
XBW1_RS13150	COG0583	DNA-binding transcription factor activity
XBW1_RS13155	COG2814	Major facilitator Superfamily
XBW1_RS13160	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
XBW1_RS13165	COG0307	riboflavin synthase, alpha
XBW1_RS13170	COG0534	Mate efflux family protein
XBW1_RS13190	COG4238	major outer membrane lipoprotein
XBW1_RS13195	COG1388	LysM domain
XBW1_RS13195	COG1376	ErfK ybiS ycfS ynhG family protein
XBW1_RS13200	COG2050	protein possibly involved in aromatic compounds catabolism
XBW1_RS13205	COG0247	lactate metabolic process
XBW1_RS13205	COG0277	FAD linked oxidase domain protein
XBW1_RS13210	COG0628	permease
XBW1_RS13215	COG0574	Belongs to the PEP-utilizing enzyme family
XBW1_RS13215	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
XBW1_RS13220	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
XBW1_RS13225	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
XBW1_RS13230	COG4771	TonB-dependent receptor
XBW1_RS13235	COG3720	iron ion transport
XBW1_RS13240	COG4558	Periplasmic binding protein
XBW1_RS13245	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
XBW1_RS13250	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
XBW1_RS13260	COG2207	Transcriptional regulator
XBW1_RS13265	COG0095	Lipoate-protein ligase
XBW1_RS13270	COG0791	NLP P60 protein
XBW1_RS13275	COG2076	Multidrug Resistance protein
XBW1_RS13280	COG2076	Multidrug Resistance protein
XBW1_RS13285	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
XBW1_RS13290	COG0726	polysaccharide deacetylase
XBW1_RS13295	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
XBW1_RS13295	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
XBW1_RS13300	COG0463	Glycosyl transferase, family 2
XBW1_RS13305	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
XBW1_RS13310	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
XBW1_RS13315	COG4139	cobalamin transport
XBW1_RS13320	COG0776	regulation of translation
XBW1_RS13325	COG0072	phenylalanine-tRNA ligase activity
XBW1_RS13325	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
XBW1_RS13340	COG0291	Belongs to the bacterial ribosomal protein bL35 family
XBW1_RS13345	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
XBW1_RS13350	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
XBW1_RS13475	COG0484	heat shock protein binding
XBW1_RS13505	COG0305	Participates in initiation and elongation during chromosome replication
XBW1_RS13665	COG0803	Belongs to the bacterial solute-binding protein 9 family
XBW1_RS13670	COG1121	(ABC) transporter
XBW1_RS13675	COG1108	ABC-type Mn2 Zn2 transport systems permease components
XBW1_RS13680	COG1108	ABC-type Mn2 Zn2 transport systems permease components
XBW1_RS13685	COG3001	Fructosamine kinase
XBW1_RS13725	COG3335	DDE superfamily endonuclease
XBW1_RS13735	COG0642	Histidine kinase
XBW1_RS13745	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
XBW1_RS13750	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
XBW1_RS13755	COG0101	tRNA pseudouridine synthase activity
XBW1_RS13760	COG0586	Pfam SNARE associated Golgi protein
XBW1_RS13765	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
XBW1_RS13770	COG0285	dihydrofolate synthase activity
XBW1_RS13775	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
XBW1_RS13780	COG1286	toxin biosynthetic process
XBW1_RS13785	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
XBW1_RS13790	COG0163	prenyltransferase activity
XBW1_RS13795	COG1090	epimerase
XBW1_RS13800	COG0625	glutathione transferase activity
XBW1_RS13825	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
XBW1_RS13825	COG2070	2-Nitropropane dioxygenase
XBW1_RS13830	COG1028	Short-chain dehydrogenase reductase Sdr
XBW1_RS13840	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
XBW1_RS13850	COG1131	(ABC) transporter
XBW1_RS13860	COG0488	(ABC) transporter
XBW1_RS13870	COG0488	(ABC) transporter
XBW1_RS13875	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
XBW1_RS13880	COG3138	arginine N-succinyltransferase
XBW1_RS13885	COG1012	belongs to the aldehyde dehydrogenase family
XBW1_RS13890	COG3724	N-succinylarginine dihydrolase activity
XBW1_RS13895	COG2988	succinylglutamate desuccinylase activity
XBW1_RS13900	COG1113	amino acid transport
XBW1_RS13905	COG0857	belongs to the CobB CobQ family
XBW1_RS13905	COG0280	phosphate acetyltransferase
XBW1_RS13910	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
XBW1_RS13920	COG3013	Belongs to the UPF0304 family
XBW1_RS13925	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
XBW1_RS13930	COG0471	metal ion transport
XBW1_RS13930	COG0490	domain, Protein
XBW1_RS13940	COG0436	Aminotransferase
XBW1_RS13945	COG0583	DNA-binding transcription factor activity
XBW1_RS13950	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XBW1_RS13955	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XBW1_RS13960	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XBW1_RS13960	COG0649	NAD binding
XBW1_RS13975	COG1034	ATP synthesis coupled electron transport
XBW1_RS13980	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
XBW1_RS13985	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XBW1_RS13990	COG0839	Belongs to the complex I subunit 6 family
XBW1_RS13995	COG0713	ATP synthesis coupled electron transport
XBW1_RS14000	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
XBW1_RS14005	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XBW1_RS14010	COG1007	ATP synthesis coupled electron transport
XBW1_RS14025	COG5433	transposase activity
XBW1_RS14045	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
XBW1_RS14050	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
XBW1_RS14050	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XBW1_RS14075	COG3101	peptidyl-lysine hydroxylation
XBW1_RS14080	COG0730	response to heat
XBW1_RS14085	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
XBW1_RS14100	COG2986	histidine ammonia-lyase
XBW1_RS14105	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
XBW1_RS14115	COG0010	Belongs to the arginase family
XBW1_RS14120	COG1228	amidohydrolase
XBW1_RS14125	COG2840	Smr protein MutS2
XBW1_RS14215	COG0740	serine-type endopeptidase activity
XBW1_RS14220	COG4695	Portal protein
XBW1_RS14350	COG2920	part of a sulfur-relay system
XBW1_RS14355	COG1254	Belongs to the acylphosphatase family
XBW1_RS14360	COG3785	DNA binding
XBW1_RS14365	COG1832	CoA-binding protein
XBW1_RS14370	COG0210	DNA helicase
XBW1_RS14375	COG1289	transmembrane transporter activity
XBW1_RS14390	COG2814	Major facilitator Superfamily
XBW1_RS14405	COG3070	regulator of competence-specific genes
XBW1_RS14420	COG3120	sequence-specific DNA binding
XBW1_RS14425	COG1067	ATP-dependent peptidase activity
XBW1_RS14430	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
XBW1_RS14435	COG3130	regulation of translation
XBW1_RS14440	COG3009	Protein conserved in bacteria
XBW1_RS14445	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
XBW1_RS14445	COG3008	intermembrane lipid transfer
XBW1_RS14450	COG2995	paraquat-inducible protein a
XBW1_RS14455	COG0488	(ABC) transporter
XBW1_RS14460	COG0116	Belongs to the methyltransferase superfamily
XBW1_RS14460	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
XBW1_RS14465	COG3217	Mosc domain protein beta barrel domain protein
XBW1_RS14465	COG0633	Ferredoxin
XBW1_RS14475	COG0167	dihydroorotate dehydrogenase activity
XBW1_RS14480	COG0308	aminopeptidase N
XBW1_RS14485	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
XBW1_RS14490	COG0017	Asparaginyl-tRNA synthetase
XBW1_RS14495	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
XBW1_RS14500	COG1448	Aminotransferase
XBW1_RS14505	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
XBW1_RS14510	COG3108	Peptidase M15
XBW1_RS14520	COG2989	Protein conserved in bacteria
XBW1_RS14525	COG3700	Belongs to the class B bacterial acid phosphatase family
XBW1_RS14530	COG0583	DNA-binding transcription factor activity
XBW1_RS14540	COG0585	pseudouridine synthase activity
XBW1_RS14545	COG0635	Involved in the biosynthesis of porphyrin-containing compound
XBW1_RS14565	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
XBW1_RS14575	COG0563	adenylate kinase activity
XBW1_RS14590	COG1181	Belongs to the D-alanine--D-alanine ligase family
XBW1_RS14605	COG0667	Aldo Keto reductase
XBW1_RS14620	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
XBW1_RS14625	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
XBW1_RS14630	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
XBW1_RS14635	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
XBW1_RS14640	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
XBW1_RS14645	COG1434	Gram-negative-bacterium-type cell wall biogenesis
XBW1_RS14650	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
XBW1_RS14655	COG2835	tetraacyldisaccharide 4'-kinase activity
XBW1_RS14660	COG1663	tetraacyldisaccharide 4'-kinase activity
XBW1_RS14665	COG1132	(ABC) transporter
XBW1_RS14670	COG2333	competence protein COMEC
XBW1_RS14670	COG0658	competence protein
XBW1_RS14680	COG0539	negative regulation of cytoplasmic translation
XBW1_RS14685	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
XBW1_RS14690	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
XBW1_RS14695	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
XBW1_RS14705	COG0252	asparaginase activity
XBW1_RS14710	COG1944	ATP diphosphatase activity
XBW1_RS14720	COG2116	formate transmembrane transporter activity
XBW1_RS14735	COG1882	Formate acetyltransferase
XBW1_RS14740	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
XBW1_RS14755	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
XBW1_RS14760	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
XBW1_RS14765	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
XBW1_RS14770	COG3107	peptidoglycan biosynthetic process
XBW1_RS14770	COG1674	ftsk spoiiie
XBW1_RS14775	COG1522	sequence-specific DNA binding
XBW1_RS14780	COG0492	ferredoxin-NADP+ reductase activity
XBW1_RS14790	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
XBW1_RS14795	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
XBW1_RS14800	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
XBW1_RS14805	COG0542	response to heat
XBW1_RS14810	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
XBW1_RS14815	COG1278	Cold shock
XBW1_RS14820	COG3293	Transposase
XBW1_RS14825	COG2431	L-lysine efflux transmembrane transporter activity
XBW1_RS14830	COG1126	abc transporter atp-binding protein
XBW1_RS14835	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
XBW1_RS14840	COG4215	(ABC) transporter
XBW1_RS14845	COG4160	amino acid transport
XBW1_RS14850	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
XBW1_RS14870	COG0671	phosphoesterase, PA-phosphatase related
XBW1_RS14875	COG0814	amino acid
XBW1_RS14880	COG1686	Belongs to the peptidase S11 family
XBW1_RS14885	COG0625	glutathione transferase activity
XBW1_RS14890	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
XBW1_RS14895	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
XBW1_RS14900	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
XBW1_RS14900	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
XBW1_RS14905	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
XBW1_RS14905	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
XBW1_RS14910	COG0131	Imidazoleglycerol-phosphate dehydratase
XBW1_RS14910	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
XBW1_RS14915	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
XBW1_RS14920	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
XBW1_RS14925	COG0107	imidazoleglycerol-phosphate synthase activity
XBW1_RS14930	COG0140	phosphoribosyl-ATP diphosphatase activity
XBW1_RS14930	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
XBW1_RS14935	COG1454	alcohol dehydrogenase
XBW1_RS14945	COG5433	transposase activity
XBW1_RS14955	COG5433	transposase activity
XBW1_RS14960	COG1253	flavin adenine dinucleotide binding
XBW1_RS14965	COG5301	cellulose 1,4-beta-cellobiosidase activity
XBW1_RS14985	COG2982	Protein involved in outer membrane biogenesis
XBW1_RS14990	COG0717	Belongs to the dCTP deaminase family
XBW1_RS14995	COG0572	uridine kinase
XBW1_RS15000	COG0489	protein tyrosine kinase activity
XBW1_RS15005	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
XBW1_RS15005	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
XBW1_RS15010	COG1380	Effector of murein hydrolase LrgA
XBW1_RS15015	COG1346	cytolysis
XBW1_RS15020	COG0295	cytidine deaminase activity
XBW1_RS15025	COG0281	malic enzyme
XBW1_RS15030	COG2949	membrane
XBW1_RS15035	COG2311	Membrane
XBW1_RS15040	COG0302	gtp cyclohydrolase
XBW1_RS15045	COG0477	Major facilitator Superfamily
XBW1_RS15050	COG0303	'Molybdopterin
XBW1_RS15055	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
XBW1_RS15075	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
XBW1_RS15080	COG0488	(ABC) transporter
XBW1_RS15090	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
XBW1_RS15095	COG0561	phosphatase activity
XBW1_RS15100	COG0673	inositol 2-dehydrogenase activity
XBW1_RS15175	COG5006	permease, DMT superfamily
XBW1_RS15185	COG2824	Alkylphosphonate utilization operon protein PhnA
XBW1_RS15210	COG1131	(ABC) transporter
XBW1_RS15220	COG2897	thiosulfate sulfurtransferase activity
XBW1_RS15225	COG2261	transglycosylase associated protein
XBW1_RS15230	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
XBW1_RS15235	COG0513	Belongs to the DEAD box helicase family
XBW1_RS15240	COG1309	transcriptional regulator
XBW1_RS15250	COG1131	(ABC) transporter
XBW1_RS15255	COG0842	Transport permease protein
XBW1_RS15260	COG0842	Transport permease protein
XBW1_RS15265	COG0670	Belongs to the BI1 family
XBW1_RS15270	COG0314	molybdopterin synthase activity
XBW1_RS15275	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
XBW1_RS15280	COG0315	cyclic pyranopterin monophosphate synthase activity
XBW1_RS15285	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
XBW1_RS15290	COG0391	Required for morphogenesis under gluconeogenic growth conditions
XBW1_RS15295	COG0556	nucleotide-excision repair
XBW1_RS15305	COG2226	methyltransferase
XBW1_RS15310	COG0156	8-amino-7-oxononanoate synthase activity
XBW1_RS15315	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
XBW1_RS15330	COG2706	6-phosphogluconolactonase activity
XBW1_RS15335	COG0561	phosphatase activity
XBW1_RS15340	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
XBW1_RS15345	COG4149	molybdate abc transporter
XBW1_RS15350	COG0725	ABC transporter, periplasmic molybdate-binding protein
XBW1_RS15355	COG3585	molybdate ion transport
XBW1_RS15355	COG2005	Transcriptional regulator
XBW1_RS15360	COG1119	ATPase activity
XBW1_RS15370	COG0588	phosphoglycerate mutase activity
XBW1_RS15375	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
XBW1_RS15390	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
XBW1_RS15395	COG2885	chlorophyll binding
XBW1_RS15400	COG0823	Involved in the tonB-independent uptake of proteins
XBW1_RS15405	COG3064	Membrane
XBW1_RS15405	COG3064	Membrane
XBW1_RS15410	COG0848	biopolymer transport protein
XBW1_RS15415	COG0811	peptide transport
XBW1_RS15420	COG0824	Thioesterase
XBW1_RS15425	COG3790	cyd operon protein YbgE
XBW1_RS15430	COG1294	oxidase, subunit
XBW1_RS15435	COG1271	oxidase subunit
XBW1_RS15440	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
XBW1_RS15445	COG0045	succinate-CoA ligase (ADP-forming) activity
XBW1_RS15450	COG0508	dehydrogenase complex catalyzes the overall conversion of
XBW1_RS15455	COG0567	Dehydrogenase, E1 component
XBW1_RS15465	COG1053	succinate dehydrogenase
XBW1_RS15470	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
XBW1_RS15480	COG0372	Belongs to the citrate synthase family
XBW1_RS15490	COG2814	Major facilitator Superfamily
XBW1_RS15495	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
XBW1_RS15510	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
XBW1_RS15515	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
XBW1_RS15520	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
XBW1_RS15525	COG2205	protein histidine kinase activity
XBW1_RS15530	COG0745	RESPONSE REGULATOR receiver
XBW1_RS15540	COG0033	Phosphoglucomutase
XBW1_RS15545	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
XBW1_RS15550	COG0596	Alpha beta hydrolase
XBW1_RS15560	COG3293	Transposase
XBW1_RS15580	COG1073	alpha beta
XBW1_RS15580	COG3064	Membrane
XBW1_RS15580	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
XBW1_RS15585	COG2994	toxin metabolic process
XBW1_RS15610	COG4977	sequence-specific DNA binding
XBW1_RS15625	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XBW1_RS15640	COG5433	transposase activity
XBW1_RS15650	COG0716	FMN binding
XBW1_RS15655	COG0735	belongs to the Fur family
XBW1_RS15665	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
XBW1_RS15685	COG0673	inositol 2-dehydrogenase activity
XBW1_RS15690	COG2190	(PTS) system
XBW1_RS15690	COG1263	PTS System
XBW1_RS15690	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
XBW1_RS15695	COG0363	glucosamine-6-phosphate deaminase activity
XBW1_RS15700	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
XBW1_RS15705	COG1940	carbohydrate kinase activity
XBW1_RS15705	COG1846	Transcriptional regulator
XBW1_RS15740	COG2814	Major facilitator Superfamily
XBW1_RS15750	COG3293	Transposase
XBW1_RS15755	COG0789	Transcriptional regulator
XBW1_RS15760	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XBW1_RS15765	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
XBW1_RS15770	COG1702	phosphate starvation-inducible protein PhoH
XBW1_RS15775	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
XBW1_RS15780	COG4535	Mg2 and Co2 transporter CorC
XBW1_RS15785	COG0815	Transfers the fatty acyl group on membrane lipoproteins
XBW1_RS15795	COG0765	amino acid transport
XBW1_RS15800	COG0765	amino acid transport
XBW1_RS15805	COG1126	abc transporter atp-binding protein
XBW1_RS15810	COG0495	leucyl-tRNA aminoacylation
XBW1_RS15815	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
XBW1_RS15820	COG1466	dna polymerase III delta subunit
XBW1_RS15830	COG0799	negative regulation of ribosome biogenesis
XBW1_RS15835	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
XBW1_RS15840	COG0768	penicillin binding
XBW1_RS15845	COG0772	Belongs to the SEDS family
XBW1_RS15850	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
XBW1_RS15855	COG1686	Belongs to the peptidase S11 family
XBW1_RS15860	COG2921	Belongs to the UPF0250 family
XBW1_RS15870	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
XBW1_RS15880	COG0321	lipoyl(octanoyl) transferase activity
XBW1_RS15885	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
XBW1_RS15890	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
XBW1_RS15895	COG1278	Cold shock
XBW1_RS15900	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
XBW1_RS15905	COG4175	Glycine betaine
XBW1_RS15910	COG4176	ABC-type proline glycine betaine transport system permease component
XBW1_RS15915	COG2113	Glycine betaine
XBW1_RS15920	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
XBW1_RS15930	COG1846	Transcriptional regulator
XBW1_RS15935	COG1566	PFAM secretion protein HlyD family protein
XBW1_RS15940	COG2814	Major facilitator Superfamily
XBW1_RS15955	COG3486	L-lysine 6-monooxygenase (NADPH) activity
XBW1_RS15960	COG4114	ferric iron reductase
XBW1_RS15965	COG1120	ATPase activity
XBW1_RS15970	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
XBW1_RS15975	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
XBW1_RS15980	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
XBW1_RS15985	COG4773	Receptor
XBW1_RS15995	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
XBW1_RS16000	COG3148	PFAM DTW domain containing protein
XBW1_RS16010	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XBW1_RS16015	COG5544	Lipoprotein
XBW1_RS16050	COG0542	response to heat
XBW1_RS16055	COG1496	oxidoreductase activity
XBW1_RS16060	COG0564	pseudouridine synthase activity
XBW1_RS16065	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XBW1_RS16070	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
XBW1_RS16075	COG0077	Prephenate dehydratase
XBW1_RS16075	COG1605	Chorismate mutase
XBW1_RS16080	COG1605	Chorismate mutase
XBW1_RS16080	COG0287	Prephenate dehydrogenase
XBW1_RS16085	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
XBW1_RS16090	COG0335	large ribosomal subunit rRNA binding
XBW1_RS16095	COG0336	Belongs to the RNA methyltransferase TrmD family
XBW1_RS16100	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
XBW1_RS16110	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
XBW1_RS16115	COG4137	Cytochrome C assembly protein
XBW1_RS16120	COG4536	flavin adenine dinucleotide binding
XBW1_RS16125	COG1854	S-ribosylhomocysteine lyase activity
XBW1_RS16130	COG2918	glutathione biosynthetic process
XBW1_RS16160	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
XBW1_RS16165	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
XBW1_RS16180	COG2814	Major facilitator Superfamily
XBW1_RS16185	COG0318	PFAM AMP-dependent synthetase and ligase
XBW1_RS16185	COG0204	Acyl-transferase
XBW1_RS16190	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
XBW1_RS16195	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
XBW1_RS16200	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
XBW1_RS16210	COG1073	alpha beta
XBW1_RS16215	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
XBW1_RS16225	COG2195	Cleaves the N-terminal amino acid of tripeptides
XBW1_RS16230	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
XBW1_RS16240	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
XBW1_RS16245	COG1309	transcriptional regulator
XBW1_RS16250	COG1012	belongs to the aldehyde dehydrogenase family
XBW1_RS16255	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
XBW1_RS16270	COG1629	transport
XBW1_RS16275	COG1595	DNA-templated transcription, initiation
XBW1_RS16280	COG2991	Protein conserved in bacteria
XBW1_RS16285	COG1477	protein flavinylation
XBW1_RS16295	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
XBW1_RS16300	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
XBW1_RS16305	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
XBW1_RS16310	COG1805	sodium ion transport
XBW1_RS16315	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
XBW1_RS16320	COG3034	peptidoglycan biosynthetic process
XBW1_RS16325	COG0121	glutamine amidotransferase
XBW1_RS16330	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
XBW1_RS16335	COG1960	acyl-CoA dehydrogenase activity
XBW1_RS16345	COG0583	DNA-binding transcription factor activity
XBW1_RS16350	COG0583	DNA-binding transcription factor activity
XBW1_RS16370	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
XBW1_RS16375	COG1385	rRNA (uridine-N3-)-methyltransferase activity
XBW1_RS16380	COG0189	ligase activity
XBW1_RS16385	COG1678	Uncharacterized ACR, COG1678
XBW1_RS16390	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
XBW1_RS16395	COG2805	Type II/IV secretion system protein
XBW1_RS16400	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
XBW1_RS16405	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
XBW1_RS16410	COG0762	integral membrane protein
XBW1_RS16415	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
XBW1_RS16420	COG0635	Involved in the biosynthesis of porphyrin-containing compound
XBW1_RS16425	COG4607	ABC-type enterochelin transport system periplasmic component
XBW1_RS16435	COG2066	Belongs to the glutaminase family
XBW1_RS16440	COG3171	Protein conserved in bacteria
XBW1_RS16445	COG0220	tRNA (guanine-N7-)-methyltransferase activity
XBW1_RS16450	COG1194	a g-specific adenine glycosylase
XBW1_RS16455	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
XBW1_RS16460	COG0741	lytic transglycosylase activity
XBW1_RS16470	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
XBW1_RS16560	COG3335	DDE superfamily endonuclease
XBW1_RS16580	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
XBW1_RS16590	COG3335	DDE superfamily endonuclease
XBW1_RS16630	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
XBW1_RS16655	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
XBW1_RS16705	COG0305	Participates in initiation and elongation during chromosome replication
XBW1_RS16745	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
XBW1_RS16980	COG3335	DDE superfamily endonuclease
XBW1_RS17005	COG0733	neurotransmitter:sodium symporter activity
XBW1_RS17015	COG3293	Transposase
XBW1_RS17025	COG0501	Belongs to the peptidase M48B family
XBW1_RS17095	COG0443	Heat shock 70 kDa protein
XBW1_RS17120	COG5433	transposase activity
XBW1_RS17125	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
XBW1_RS17130	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
XBW1_RS17135	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
XBW1_RS17140	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
XBW1_RS17145	COG4974	Belongs to the 'phage' integrase family
XBW1_RS17150	COG0716	FMN binding
XBW1_RS17160	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
XBW1_RS17165	COG0354	folic acid binding
XBW1_RS17175	COG0477	Major facilitator Superfamily
XBW1_RS17180	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
XBW1_RS17180	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
XBW1_RS17185	COG0509	glycine decarboxylation via glycine cleavage system
XBW1_RS17190	COG0404	The glycine cleavage system catalyzes the degradation of glycine
XBW1_RS17195	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XBW1_RS17200	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XBW1_RS17205	COG0006	proline dipeptidase activity
XBW1_RS17210	COG3079	Belongs to the UPF0149 family
XBW1_RS17220	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
XBW1_RS17225	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
XBW1_RS17230	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
XBW1_RS17235	COG0583	DNA-binding transcription factor activity
XBW1_RS17245	COG1279	arginine transmembrane transporter activity
XBW1_RS17250	COG0668	transmembrane transport
XBW1_RS17255	COG3112	Uncharacterised protein family (UPF0231)
XBW1_RS17265	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
XBW1_RS17270	COG0508	dehydrogenase complex catalyzes the overall conversion of
XBW1_RS17275	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
XBW1_RS17280	COG2186	Transcriptional regulator
XBW1_RS17285	COG3725	Membrane protein required for beta-lactamase induction
XBW1_RS17290	COG3023	N-Acetylmuramoyl-L-alanine amidase
XBW1_RS17295	COG4969	Belongs to the N-Me-Phe pilin family
XBW1_RS17300	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
XBW1_RS17310	COG0237	dephospho-CoA kinase activity
XBW1_RS17315	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
XBW1_RS17320	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
XBW1_RS17325	COG0494	nUDIX hydrolase
XBW1_RS17330	COG0488	(ABC) transporter
XBW1_RS17335	COG0653	protein targeting
XBW1_RS17350	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
XBW1_RS17360	COG0849	cell division
XBW1_RS17365	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
XBW1_RS17370	COG1181	Belongs to the D-alanine--D-alanine ligase family
XBW1_RS17375	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
XBW1_RS17380	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
XBW1_RS17385	COG0772	Belongs to the SEDS family
XBW1_RS17390	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
XBW1_RS17395	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
XBW1_RS17400	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
XBW1_RS17405	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
XBW1_RS17410	COG0768	penicillin binding
XBW1_RS17415	COG3116	cell division
XBW1_RS17420	COG0275	rRNA processing
XBW1_RS17425	COG2001	Belongs to the MraZ family
XBW1_RS17440	COG0028	Belongs to the TPP enzyme family
XBW1_RS17445	COG1022	Amp-dependent synthetase and ligase
XBW1_RS17460	COG0473	3-isopropylmalate dehydrogenase activity
XBW1_RS17465	COG3066	DNA modification
XBW1_RS17475	COG0242	peptide deformylase activity
XBW1_RS17480	COG0626	cystathionine gamma-synthase activity
XBW1_RS17500	COG4122	O-methyltransferase activity
XBW1_RS17505	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
XBW1_RS17525	COG0066	3-isopropylmalate dehydratase activity
XBW1_RS17530	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
XBW1_RS17535	COG0583	DNA-binding transcription factor activity
XBW1_RS17545	COG1881	PFAM PEBP family protein
XBW1_RS17550	COG0010	Belongs to the arginase family
XBW1_RS17555	COG1166	arginine decarboxylase activity
XBW1_RS17560	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
XBW1_RS17565	COG3091	SprT-like family
XBW1_RS17580	COG1301	dicarboxylic acid transport
XBW1_RS17590	COG0471	metal ion transport
XBW1_RS17595	COG0148	phosphopyruvate hydratase activity
XBW1_RS17600	COG0504	CTP synthase activity
XBW1_RS17605	COG3956	TIGRFAM MazG family protein
XBW1_RS17610	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
XBW1_RS17615	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
XBW1_RS17630	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
XBW1_RS17635	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
XBW1_RS17640	COG0316	Belongs to the HesB IscA family
XBW1_RS17645	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
XBW1_RS17670	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
XBW1_RS17675	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
XBW1_RS17705	COG0156	8-amino-7-oxononanoate synthase activity
XBW1_RS17715	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
XBW1_RS17720	COG1643	Atp-dependent helicase
XBW1_RS17725	COG1489	DNA binding
XBW1_RS17735	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
XBW1_RS17745	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
XBW1_RS17750	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
XBW1_RS17755	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
XBW1_RS17760	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
XBW1_RS17765	COG0842	Transport permease protein
XBW1_RS17770	COG1131	(ABC) transporter
XBW1_RS17775	COG0288	reversible hydration of carbon dioxide
XBW1_RS17785	COG3423	Transcriptional regulator
XBW1_RS17820	COG2423	ornithine cyclodeaminase activity
XBW1_RS17840	COG0534	Mate efflux family protein
XBW1_RS17865	COG0814	amino acid
XBW1_RS17870	COG0582	viral genome integration into host DNA
XBW1_RS17875	COG0523	cobalamin synthesis protein
XBW1_RS17880	COG2879	small protein
XBW1_RS17885	COG1966	Carbon starvation protein
XBW1_RS17890	COG2194	sulfuric ester hydrolase activity
XBW1_RS17895	COG3012	SEC-C Motif Domain Protein
XBW1_RS17900	COG3335	DDE superfamily endonuclease
XBW1_RS17920	COG1278	Cold shock
XBW1_RS17950	COG2015	COG2015, Alkyl sulfatase and related hydrolases
XBW1_RS17960	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
XBW1_RS17970	COG4942	peptidase
XBW1_RS17970	COG1388	LysM domain
XBW1_RS17975	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
XBW1_RS17980	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
XBW1_RS17985	COG0585	pseudouridine synthase activity
XBW1_RS17990	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
XBW1_RS17995	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
XBW1_RS18010	COG2895	sulfate adenylyltransferase (ATP) activity
XBW1_RS18015	COG0175	sulfate reduction
XBW1_RS18020	COG1648	precorrin-2 dehydrogenase activity
XBW1_RS18020	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
XBW1_RS18025	COG0175	sulfate reduction
XBW1_RS18030	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
XBW1_RS18035	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
XBW1_RS18040	COG0720	synthase
XBW1_RS18045	COG0602	queuosine metabolic process
XBW1_RS18055	COG3021	interspecies interaction between organisms
XBW1_RS18090	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
XBW1_RS18095	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
XBW1_RS18100	COG1739	Uncharacterized protein family UPF0029
XBW1_RS18105	COG0006	proline dipeptidase activity
XBW1_RS18110	COG1024	Enoyl-CoA hydratase
XBW1_RS18110	COG1250	3-hydroxyacyl-CoA dehydrogenase
XBW1_RS18115	COG0183	Belongs to the thiolase family
XBW1_RS18125	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
XBW1_RS18140	COG0805	protein transport
XBW1_RS18145	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
XBW1_RS18150	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
XBW1_RS18155	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
XBW1_RS18160	COG3165	ubiquinone biosynthetic process from chorismate
XBW1_RS18165	COG2226	methyltransferase
XBW1_RS18170	COG1322	Protein conserved in bacteria
XBW1_RS18175	COG1322	Protein conserved in bacteria
XBW1_RS18180	COG0586	Pfam SNARE associated Golgi protein
XBW1_RS18190	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
XBW1_RS18200	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
XBW1_RS18205	COG0583	DNA-binding transcription factor activity
XBW1_RS18210	COG0025	NhaP-type Na H and K H
XBW1_RS18215	COG2252	PERMEase
XBW1_RS18230	COG3293	Transposase
XBW1_RS18260	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
XBW1_RS18265	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
XBW1_RS18285	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
XBW1_RS18295	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
XBW1_RS18315	COG1448	Aminotransferase
XBW1_RS18335	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
XBW1_RS18345	COG0735	belongs to the Fur family
XBW1_RS18355	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
XBW1_RS18360	COG2937	Belongs to the GPAT DAPAT family
XBW1_RS18365	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
XBW1_RS18370	COG3161	chorismate lyase activity
XBW1_RS18375	COG0166	Belongs to the GPI family
XBW1_RS18380	COG0527	aspartate kinase activity
XBW1_RS18385	COG1414	Transcriptional regulator
XBW1_RS18390	COG0800	Aldolase
XBW1_RS18400	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
XBW1_RS18405	COG2224	Isocitrate lyase
XBW1_RS18410	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
XBW1_RS18415	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
XBW1_RS18445	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
XBW1_RS18450	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
XBW1_RS18460	COG1464	Belongs to the NlpA lipoprotein family
XBW1_RS18470	COG1720	tRNA m6t6A37 methyltransferase activity
XBW1_RS18475	COG0442	prolyl-tRNA aminoacylation
XBW1_RS18480	COG3015	lipoprotein NlpE involved in copper resistance
XBW1_RS18485	COG4568	rho-dependent transcription termination
XBW1_RS18490	COG0037	tRNA processing
XBW1_RS18495	COG0697	spore germination
XBW1_RS18500	COG0825	malonyl-CoA metabolic process
XBW1_RS18510	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
XBW1_RS18515	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XBW1_RS18520	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XBW1_RS18525	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
XBW1_RS18530	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XBW1_RS18545	COG0750	zinc metalloprotease
XBW1_RS18550	COG0575	Belongs to the CDS family
XBW1_RS18555	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
XBW1_RS18560	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
XBW1_RS18565	COG0233	cytoplasmic translational termination
XBW1_RS18570	COG0528	UMP kinase activity
XBW1_RS18575	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
XBW1_RS18580	COG0052	Belongs to the universal ribosomal protein uS2 family
XBW1_RS18590	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
XBW1_RS18615	COG3098	single-species biofilm formation
XBW1_RS18645	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
XBW1_RS18645	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
XBW1_RS18650	COG1611	Belongs to the LOG family
XBW1_RS18655	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
XBW1_RS18685	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
XBW1_RS18690	COG2363	Small membrane protein
XBW1_RS18695	COG0583	DNA-binding transcription factor activity
XBW1_RS18700	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
XBW1_RS18705	COG2166	iron-sulfur cluster assembly
XBW1_RS18710	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
XBW1_RS18715	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
XBW1_RS18730	COG0860	N-Acetylmuramoyl-L-alanine amidase
XBW1_RS18735	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
XBW1_RS18735	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
XBW1_RS18740	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
XBW1_RS18745	COG1074	ATP-dependent DNA helicase activity
XBW1_RS18755	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
XBW1_RS18770	COG4795	General secretion pathway protein
XBW1_RS18780	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
XBW1_RS18785	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
XBW1_RS18795	COG0494	nUDIX hydrolase
XBW1_RS18800	COG4143	(ABC) transporter
XBW1_RS18805	COG1178	ABC-type Fe3 transport system permease component
XBW1_RS18810	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
XBW1_RS18815	COG3293	Transposase
XBW1_RS18850	COG2992	FlgJ-related protein
XBW1_RS18870	COG2610	gluconate transmembrane transporter activity
XBW1_RS18875	COG3265	gluconokinase activity
XBW1_RS18880	COG1609	Transcriptional regulator
XBW1_RS18890	COG1486	melibiose metabolic process
XBW1_RS18900	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
XBW1_RS18910	COG1309	transcriptional regulator
XBW1_RS18915	COG2814	Major facilitator Superfamily
XBW1_RS18920	COG1028	Short-chain dehydrogenase reductase Sdr
XBW1_RS18940	COG1487	ribonuclease activity
XBW1_RS18960	COG1203	CRISPR-associated helicase, Cas3
XBW1_RS19005	COG1846	Transcriptional regulator
XBW1_RS19015	COG2873	o-acetylhomoserine
XBW1_RS19065	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
XBW1_RS19085	COG1177	transmembrane transport
XBW1_RS19105	COG1105	Belongs to the carbohydrate kinase PfkB family
XBW1_RS19105	COG1105	Belongs to the carbohydrate kinase PfkB family
XBW1_RS19110	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
XBW1_RS19110	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
XBW1_RS19110	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
XBW1_RS19135	COG0583	DNA-binding transcription factor activity
XBW1_RS19140	COG1301	dicarboxylic acid transport
XBW1_RS19230	COG3423	Transcriptional regulator
XBW1_RS19250	COG3293	Transposase
XBW1_RS19275	COG3293	Transposase
XBW1_RS19285	COG0582	viral genome integration into host DNA
XBW1_RS19295	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
XBW1_RS19300	COG0795	lipopolysaccharide-transporting ATPase activity
XBW1_RS19305	COG0795	lipopolysaccharide-transporting ATPase activity
XBW1_RS19310	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
XBW1_RS19315	COG2927	DNA polymerase III (CHI subunit)
XBW1_RS19320	COG0525	valine-tRNA ligase activity
XBW1_RS19325	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
XBW1_RS19330	COG0765	amino acid transport
XBW1_RS19335	COG1126	abc transporter atp-binding protein
XBW1_RS19340	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
XBW1_RS19350	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
XBW1_RS19355	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
XBW1_RS19360	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
XBW1_RS19365	COG2175	clavaminate synthase activity
XBW1_RS19375	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
XBW1_RS19405	COG1280	lysine exporter protein (LysE YggA)
XBW1_RS19410	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
XBW1_RS19415	COG3541	Predicted nucleotidyltransferase
XBW1_RS19420	COG1690	Belongs to the RtcB family
XBW1_RS19430	COG4650	regulator
XBW1_RS19460	COG0512	Glutamine amidotransferase of anthranilate synthase
XBW1_RS19470	COG1028	Short-chain dehydrogenase reductase Sdr
XBW1_RS19500	COG0540	Belongs to the ATCase OTCase family
XBW1_RS19510	COG5505	Protein of unknown function (DUF819)
XBW1_RS19520	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
XBW1_RS19530	COG3787	Belongs to the UPF0306 family
XBW1_RS19540	COG2827	Endonuclease containing a URI domain
XBW1_RS19545	COG3153	acetyltransferase
XBW1_RS19550	COG3154	lipid carrier protein
XBW1_RS19565	COG2814	Major facilitator Superfamily
XBW1_RS19575	COG1028	Short-chain dehydrogenase reductase Sdr
XBW1_RS19580	COG1028	Short-chain dehydrogenase reductase Sdr
XBW1_RS19585	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
XBW1_RS19595	COG2373	Large extracellular alpha-helical protein
XBW1_RS19595	COG1388	LysM domain
XBW1_RS19595	COG4932	domain protein
XBW1_RS19600	COG3275	phosphorelay sensor kinase activity
XBW1_RS19610	COG0513	Belongs to the DEAD box helicase family
XBW1_RS19625	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
XBW1_RS19630	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
XBW1_RS19635	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
XBW1_RS19640	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
XBW1_RS19645	COG0195	Participates in both transcription termination and antitermination
XBW1_RS19650	COG0779	Required for maturation of 30S ribosomal subunits
XBW1_RS19665	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
XBW1_RS19670	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
XBW1_RS19675	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
XBW1_RS19685	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
XBW1_RS19690	COG1534	Rna-binding protein
XBW1_RS19700	COG2027	D-alanyl-D-alanine carboxypeptidase
XBW1_RS19705	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
XBW1_RS19715	COG0261	This protein binds to 23S rRNA in the presence of protein L20
XBW1_RS19720	COG0142	geranyltranstransferase activity
XBW1_RS19735	COG3423	Transcriptional regulator
XBW1_RS19740	COG0039	L-malate dehydrogenase activity
XBW1_RS19750	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
XBW1_RS19755	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
XBW1_RS19765	COG2105	PFAM AIG2 family protein
XBW1_RS19780	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
XBW1_RS19785	COG1253	flavin adenine dinucleotide binding
XBW1_RS19795	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
XBW1_RS19805	COG0545	Peptidyl-prolyl cis-trans isomerase
XBW1_RS19815	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
XBW1_RS19820	COG2965	DNA replication, synthesis of RNA primer
XBW1_RS19825	COG0360	Binds together with S18 to 16S ribosomal RNA
XBW1_RS19830	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
XBW1_RS19835	COG0557	exoribonuclease II activity
XBW1_RS19840	COG1959	2 iron, 2 sulfur cluster binding
XBW1_RS19845	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
XBW1_RS19850	COG0330	HflC and HflK could
XBW1_RS19855	COG0330	HflC and HflK could
XBW1_RS19860	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
XBW1_RS19865	COG1923	regulation of RNA biosynthetic process
XBW1_RS19870	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
XBW1_RS19875	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
XBW1_RS19880	COG0860	N-Acetylmuramoyl-L-alanine amidase
XBW1_RS19885	COG0802	atpase or kinase
XBW1_RS19890	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
XBW1_RS19895	COG2368	4-hydroxyphenylacetate
XBW1_RS19905	COG0154	amidase activity
XBW1_RS19915	COG2814	Major facilitator Superfamily
XBW1_RS19930	COG0583	DNA-binding transcription factor activity
XBW1_RS19945	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XBW1_RS19970	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
XBW1_RS19975	COG1162	GTPase activity
XBW1_RS19980	COG0688	phosphatidylethanolamine metabolic process
XBW1_RS19985	COG1511	domain protein
XBW1_RS19985	COG3264	Mechanosensitive ion channel
XBW1_RS20000	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
XBW1_RS20005	COG3152	Membrane
XBW1_RS20010	COG1609	Transcriptional regulator
XBW1_RS20015	COG0477	Major facilitator Superfamily
XBW1_RS20020	COG0561	phosphatase activity
XBW1_RS20025	COG2267	carboxylic ester hydrolase activity
XBW1_RS20030	COG0514	ATP-dependent DNA helicase (RecQ)
XBW1_RS20035	COG2050	protein possibly involved in aromatic compounds catabolism
XBW1_RS20055	COG0598	Magnesium transport protein CorA
XBW1_RS20060	COG0210	DNA helicase
XBW1_RS20065	COG1011	Hydrolase
XBW1_RS20075	COG3159	Protein conserved in bacteria
XBW1_RS20080	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
XBW1_RS20090	COG1965	Belongs to the frataxin family
XBW1_RS20115	COG0181	hydroxymethylbilane synthase activity
XBW1_RS20125	COG2959	enzyme of heme biosynthesis
XBW1_RS20130	COG3071	HemY protein
XBW1_RS20160	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
XBW1_RS20170	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
XBW1_RS20175	COG2244	polysaccharide biosynthetic process
XBW1_RS20180	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
XBW1_RS20185	COG0456	acetyltransferase
XBW1_RS20190	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
XBW1_RS20195	COG1088	dTDP-glucose 4,6-dehydratase activity
XBW1_RS20200	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
XBW1_RS20205	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
XBW1_RS20210	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
XBW1_RS20215	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
XBW1_RS20220	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
XBW1_RS20225	COG3118	belongs to the thioredoxin family
XBW1_RS20230	COG0513	Belongs to the DEAD box helicase family
XBW1_RS20235	COG0248	Ppx GppA phosphatase
XBW1_RS20240	COG0210	DNA helicase
XBW1_RS20250	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
XBW1_RS20255	COG0583	DNA-binding transcription factor activity
XBW1_RS20265	COG0129	dihydroxy-acid dehydratase activity
XBW1_RS20270	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
XBW1_RS20275	COG3978	acetolactate synthase activity
XBW1_RS20290	COG3085	chromosome segregation
XBW1_RS20295	COG0583	DNA-binding transcription factor activity
XBW1_RS20330	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
XBW1_RS20340	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
XBW1_RS20345	COG0009	L-threonylcarbamoyladenylate synthase
XBW1_RS20350	COG0551	DNA topoisomerase type I activity
XBW1_RS20355	COG0758	DNA mediated transformation
XBW1_RS20360	COG0242	peptide deformylase activity
XBW1_RS20365	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
XBW1_RS20370	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
XBW1_RS20370	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
XBW1_RS20375	COG0569	domain protein
XBW1_RS20380	COG3036	rescue of stalled ribosome
XBW1_RS20385	COG0789	Transcriptional regulator
XBW1_RS20390	COG0203	ribosomal protein L17
XBW1_RS20395	COG0202	RNA polymerase activity
XBW1_RS20400	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
XBW1_RS20410	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
XBW1_RS20415	COG0257	Belongs to the bacterial ribosomal protein bL36 family
XBW1_RS20420	COG0201	protein transport
XBW1_RS20425	COG0200	Binds to the 23S rRNA
XBW1_RS20430	COG1841	ribosomal large subunit assembly
XBW1_RS20435	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
XBW1_RS20440	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
XBW1_RS20445	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
XBW1_RS20450	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
XBW1_RS20455	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
XBW1_RS20460	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
XBW1_RS20470	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
XBW1_RS20475	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
XBW1_RS20485	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
XBW1_RS20495	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
XBW1_RS20500	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
XBW1_RS20505	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
XBW1_RS20510	COG0089	rRNA binding
XBW1_RS20515	COG0088	Forms part of the polypeptide exit tunnel
XBW1_RS20520	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
XBW1_RS20525	COG0051	transcription antitermination factor activity, RNA binding
XBW1_RS20565	COG1072	(Pantothenic acid kinase))
XBW1_RS20575	COG0812	UDP-N-acetylmuramate dehydrogenase activity
XBW1_RS20615	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
XBW1_RS20620	COG4206	TonB-dependent receptor
XBW1_RS20625	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
XBW1_RS20635	COG1309	transcriptional regulator
XBW1_RS20640	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
XBW1_RS20650	COG0165	Argininosuccinate lyase
XBW1_RS20655	COG0137	argininosuccinate synthase activity
XBW1_RS20660	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
XBW1_RS20665	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
XBW1_RS20670	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
XBW1_RS20690	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
XBW1_RS20695	COG0460	homoserine dehydrogenase
XBW1_RS20695	COG0527	aspartate kinase activity
XBW1_RS20700	COG0626	cystathionine gamma-synthase activity
XBW1_RS20715	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
XBW1_RS20720	COG1609	Transcriptional regulator
XBW1_RS20725	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
XBW1_RS20730	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
XBW1_RS20735	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
XBW1_RS20740	COG1575	Belongs to the MenA family. Type 1 subfamily
XBW1_RS20745	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
XBW1_RS20750	COG3074	FtsZ-dependent cytokinesis
XBW1_RS20760	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
XBW1_RS20765	COG2814	Major facilitator Superfamily
XBW1_RS20775	COG3152	Membrane
XBW1_RS20785	COG0149	triose-phosphate isomerase activity
XBW1_RS20790	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
XBW1_RS20795	COG0205	6-phosphofructokinase activity
XBW1_RS20800	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
XBW1_RS20805	COG4589	Belongs to the CDS family
XBW1_RS20825	COG3678	ATP-independent chaperone mediated protein folding
XBW1_RS20830	COG0745	RESPONSE REGULATOR receiver
XBW1_RS20835	COG2205	protein histidine kinase activity
XBW1_RS20845	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
XBW1_RS20870	COG1442	glycosyl transferase family 8
XBW1_RS20870	COG1216	Glycosyl transferase, family 2
XBW1_RS20885	COG0438	transferase activity, transferring glycosyl groups
XBW1_RS20910	COG3335	DDE superfamily endonuclease
XBW1_RS20915	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
XBW1_RS20920	COG1045	serine acetyltransferase
XBW1_RS20925	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
XBW1_RS20930	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
XBW1_RS20935	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
XBW1_RS20940	COG4942	peptidase
XBW1_RS20945	COG2861	carbohydrate metabolic process
XBW1_RS20950	COG1063	alcohol dehydrogenase
XBW1_RS20955	COG0156	8-amino-7-oxononanoate synthase activity
XBW1_RS20960	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
XBW1_RS20970	COG0859	PFAM glycosyl transferase family 9
XBW1_RS20985	COG0859	PFAM glycosyl transferase family 9
XBW1_RS20990	COG0438	transferase activity, transferring glycosyl groups
XBW1_RS20995	COG0438	transferase activity, transferring glycosyl groups
XBW1_RS21000	COG0859	PFAM glycosyl transferase family 9
XBW1_RS21005	COG1519	Transferase
XBW1_RS21015	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
XBW1_RS21020	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
XBW1_RS21035	COG0438	transferase activity, transferring glycosyl groups
XBW1_RS21045	COG0438	transferase activity, transferring glycosyl groups
XBW1_RS21050	COG0267	Belongs to the bacterial ribosomal protein bL33 family
XBW1_RS21060	COG2003	Belongs to the UPF0758 family
XBW1_RS21065	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
XBW1_RS21070	COG0756	dUTP diphosphatase activity
XBW1_RS21075	COG1309	transcriptional regulator
XBW1_RS21080	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
XBW1_RS21085	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
XBW1_RS21090	COG1561	YicC-like family, N-terminal region
XBW1_RS21165	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
XBW1_RS21175	COG2188	Transcriptional regulator
XBW1_RS21190	COG1368	sulfuric ester hydrolase activity
XBW1_RS21195	COG3276	selenocysteine insertion sequence binding
XBW1_RS21205	COG3058	Necessary for formate dehydrogenase activity
XBW1_RS21220	COG3311	Transcriptional regulator
XBW1_RS21230	COG2864	formate dehydrogenase
XBW1_RS21240	COG0243	molybdopterin cofactor binding
XBW1_RS21240	COG3383	formate dehydrogenase (NAD+) activity
XBW1_RS21250	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
XBW1_RS21275	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
XBW1_RS21280	COG2249	NAD(P)H dehydrogenase (quinone) activity
XBW1_RS21305	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
XBW1_RS21330	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
XBW1_RS21335	COG3335	DDE superfamily endonuclease
XBW1_RS21340	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
XBW1_RS21345	COG0706	membrane insertase activity
XBW1_RS21350	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
XBW1_RS21355	COG0594	ribonuclease P activity
XBW1_RS21360	COG0230	Belongs to the bacterial ribosomal protein bL34 family
XBW1_RS21390	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
XBW1_RS21440	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
XBW1_RS21560	COG2425	protein containing a von Willebrand factor type A (vWA) domain
XBW1_RS21870	COG1012	belongs to the aldehyde dehydrogenase family
XBW1_RS21955	COG0306	phosphate transporter
XBW1_RS22005	COG0339	signal peptide processing
XBW1_RS22295	COG2192	nodulation
XBW1_RS22315	COG3547	Transposase (IS116 IS110 IS902 family)
XBW1_RS22330	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
XBW1_RS22330	COG0300	oxidoreductase activity
XBW1_RS22330	COG3321	synthase
XBW1_RS22330	COG4221	oxidoreductase activity
XBW1_RS22335	COG5301	cellulose 1,4-beta-cellobiosidase activity
XBW1_RS22375	COG5301	cellulose 1,4-beta-cellobiosidase activity
XBW1_RS22440	COG5301	cellulose 1,4-beta-cellobiosidase activity
XBW1_RS22555	COG5301	cellulose 1,4-beta-cellobiosidase activity
XBW1_RS22580	COG5301	cellulose 1,4-beta-cellobiosidase activity
XBW1_RS22620	COG3475	LICD family