locus-tag	class	description
XDD1_RS00030	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
XDD1_RS00075	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
XDD1_RS00080	COG0592	DNA-directed DNA polymerase activity
XDD1_RS00085	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
XDD1_RS00090	COG0187	DNA topoisomerase II activity
XDD1_RS00110	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
XDD1_RS00125	COG2255	four-way junction helicase activity
XDD1_RS00200	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
XDD1_RS00205	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
XDD1_RS00210	COG0355	proton-transporting ATP synthase activity, rotational mechanism
XDD1_RS00215	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
XDD1_RS00220	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
XDD1_RS00225	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
XDD1_RS00230	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
XDD1_RS00235	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
XDD1_RS00245	COG0356	it plays a direct role in the translocation of protons across the membrane
XDD1_RS00250	COG3312	ion transport
XDD1_RS00255	COG0357	Ribosomal RNA small subunit methyltransferase G
XDD1_RS00260	COG0445	tRNA wobble uridine modification
XDD1_RS00265	COG0716	FMN binding
XDD1_RS00270	COG1522	sequence-specific DNA binding
XDD1_RS00275	COG2502	aspartate--ammonia ligase
XDD1_RS00280	COG2425	protein containing a von Willebrand factor type A (vWA) domain
XDD1_RS00285	COG0714	Associated with various cellular activities
XDD1_RS00290	COG1129	ABC transporter
XDD1_RS00295	COG1172	Belongs to the binding-protein-dependent transport system permease family
XDD1_RS00300	COG1879	ABC-type sugar transport system periplasmic component
XDD1_RS00305	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
XDD1_RS00310	COG1609	Transcriptional regulator
XDD1_RS00315	COG0477	Major facilitator Superfamily
XDD1_RS00345	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
XDD1_RS00350	COG3162	membrane
XDD1_RS00355	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
XDD1_RS00360	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
XDD1_RS00365	COG2258	MOSC domain
XDD1_RS00370	COG0180	Tryptophanyl-tRNA synthetase
XDD1_RS00375	COG0546	phosphoglycolate phosphatase activity
XDD1_RS00380	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
XDD1_RS00395	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
XDD1_RS00400	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
XDD1_RS00405	COG4796	Type ii and iii secretion system protein
XDD1_RS00425	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
XDD1_RS00430	COG0494	nUDIX hydrolase
XDD1_RS00440	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
XDD1_RS00445	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
XDD1_RS00450	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
XDD1_RS00455	COG2814	Major facilitator Superfamily
XDD1_RS00470	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
XDD1_RS00485	COG0583	DNA-binding transcription factor activity
XDD1_RS00490	COG2081	HI0933 family
XDD1_RS00495	COG0306	phosphate transporter
XDD1_RS00505	COG0589	response to stress
XDD1_RS00515	COG0742	ribosomal rna small subunit methyltransferase
XDD1_RS00530	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
XDD1_RS00550	COG0366	Alpha amylase catalytic
XDD1_RS00555	COG1263	PTS System
XDD1_RS00555	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
XDD1_RS00565	COG3327	negative regulation of DNA-templated transcription, initiation
XDD1_RS00570	COG0583	DNA-binding transcription factor activity
XDD1_RS00575	COG3335	DDE superfamily endonuclease
XDD1_RS00595	COG1561	YicC-like family, N-terminal region
XDD1_RS00600	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
XDD1_RS00605	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
XDD1_RS00610	COG1309	transcriptional regulator
XDD1_RS00615	COG0756	dUTP diphosphatase activity
XDD1_RS00620	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
XDD1_RS00625	COG2003	Belongs to the UPF0758 family
XDD1_RS00635	COG0267	Belongs to the bacterial ribosomal protein bL33 family
XDD1_RS00640	COG0438	transferase activity, transferring glycosyl groups
XDD1_RS00650	COG0438	transferase activity, transferring glycosyl groups
XDD1_RS00665	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
XDD1_RS00670	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
XDD1_RS00680	COG1519	Transferase
XDD1_RS00685	COG0859	PFAM glycosyl transferase family 9
XDD1_RS00695	COG0438	transferase activity, transferring glycosyl groups
XDD1_RS00705	COG1215	transferase activity, transferring glycosyl groups
XDD1_RS00710	COG1216	Glycosyl transferase, family 2
XDD1_RS00725	COG0859	PFAM glycosyl transferase family 9
XDD1_RS00735	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
XDD1_RS00740	COG0156	8-amino-7-oxononanoate synthase activity
XDD1_RS00745	COG1063	alcohol dehydrogenase
XDD1_RS00750	COG2861	carbohydrate metabolic process
XDD1_RS00755	COG4942	peptidase
XDD1_RS00775	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
XDD1_RS00780	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
XDD1_RS00785	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
XDD1_RS00790	COG1045	serine acetyltransferase
XDD1_RS00795	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
XDD1_RS00820	COG1086	Polysaccharide biosynthesis protein
XDD1_RS00825	COG0438	transferase activity, transferring glycosyl groups
XDD1_RS00830	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
XDD1_RS00835	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
XDD1_RS00835	COG0662	Cupin 2, conserved barrel domain protein
XDD1_RS00855	COG2205	protein histidine kinase activity
XDD1_RS00860	COG0745	RESPONSE REGULATOR receiver
XDD1_RS00865	COG3678	ATP-independent chaperone mediated protein folding
XDD1_RS00895	COG4589	Belongs to the CDS family
XDD1_RS00910	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
XDD1_RS00915	COG0149	triose-phosphate isomerase activity
XDD1_RS00925	COG3152	Membrane
XDD1_RS00935	COG2814	Major facilitator Superfamily
XDD1_RS00940	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
XDD1_RS00950	COG3074	FtsZ-dependent cytokinesis
XDD1_RS00955	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
XDD1_RS00960	COG1575	Belongs to the MenA family. Type 1 subfamily
XDD1_RS00965	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
XDD1_RS00970	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
XDD1_RS00975	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
XDD1_RS00980	COG1609	Transcriptional regulator
XDD1_RS00985	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
XDD1_RS00995	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
XDD1_RS01000	COG0626	cystathionine gamma-synthase activity
XDD1_RS01005	COG0527	aspartate kinase activity
XDD1_RS01005	COG0460	homoserine dehydrogenase
XDD1_RS01010	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
XDD1_RS01015	COG0583	DNA-binding transcription factor activity
XDD1_RS01020	COG2814	Major facilitator Superfamily
XDD1_RS01030	COG2814	Major facilitator Superfamily
XDD1_RS01055	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
XDD1_RS01060	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
XDD1_RS01070	COG0137	argininosuccinate synthase activity
XDD1_RS01075	COG0165	Argininosuccinate lyase
XDD1_RS01080	COG3335	DDE superfamily endonuclease
XDD1_RS01110	COG3547	Transposase (IS116 IS110 IS902 family)
XDD1_RS01145	COG0442	prolyl-tRNA aminoacylation
XDD1_RS01160	COG3335	DDE superfamily endonuclease
XDD1_RS01190	COG3547	Transposase (IS116 IS110 IS902 family)
XDD1_RS01220	COG3335	DDE superfamily endonuclease
XDD1_RS01230	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
XDD1_RS01245	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
XDD1_RS01250	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
XDD1_RS01285	COG0812	UDP-N-acetylmuramate dehydrogenase activity
XDD1_RS01295	COG1072	(Pantothenic acid kinase))
XDD1_RS01320	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
XDD1_RS01330	COG0051	transcription antitermination factor activity, RNA binding
XDD1_RS01335	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
XDD1_RS01340	COG0088	Forms part of the polypeptide exit tunnel
XDD1_RS01345	COG0089	rRNA binding
XDD1_RS01350	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
XDD1_RS01355	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
XDD1_RS01370	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
XDD1_RS01380	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
XDD1_RS01385	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
XDD1_RS01390	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
XDD1_RS01395	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
XDD1_RS01400	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
XDD1_RS01405	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
XDD1_RS01410	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
XDD1_RS01415	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
XDD1_RS01420	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
XDD1_RS01425	COG1841	ribosomal large subunit assembly
XDD1_RS01430	COG0200	Binds to the 23S rRNA
XDD1_RS01435	COG0201	protein transport
XDD1_RS01440	COG0257	Belongs to the bacterial ribosomal protein bL36 family
XDD1_RS01445	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
XDD1_RS01450	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
XDD1_RS01455	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
XDD1_RS01460	COG0202	RNA polymerase activity
XDD1_RS01465	COG0203	ribosomal protein L17
XDD1_RS01470	COG0789	Transcriptional regulator
XDD1_RS01475	COG3036	rescue of stalled ribosome
XDD1_RS01480	COG0569	domain protein
XDD1_RS01485	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
XDD1_RS01485	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
XDD1_RS01490	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
XDD1_RS01495	COG0242	peptide deformylase activity
XDD1_RS01500	COG0758	DNA mediated transformation
XDD1_RS01505	COG0551	DNA topoisomerase type I activity
XDD1_RS01510	COG0009	L-threonylcarbamoyladenylate synthase
XDD1_RS01515	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
XDD1_RS01525	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
XDD1_RS01560	COG0583	DNA-binding transcription factor activity
XDD1_RS01565	COG3085	chromosome segregation
XDD1_RS01580	COG3978	acetolactate synthase activity
XDD1_RS01590	COG0129	dihydroxy-acid dehydratase activity
XDD1_RS01600	COG2814	Major facilitator Superfamily
XDD1_RS01605	COG1566	PFAM secretion protein HlyD family protein
XDD1_RS01620	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
XDD1_RS01635	COG0248	Ppx GppA phosphatase
XDD1_RS01640	COG0513	Belongs to the DEAD box helicase family
XDD1_RS01645	COG3118	belongs to the thioredoxin family
XDD1_RS01650	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
XDD1_RS01655	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
XDD1_RS01660	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
XDD1_RS01665	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
XDD1_RS01670	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
XDD1_RS01675	COG1088	dTDP-glucose 4,6-dehydratase activity
XDD1_RS01680	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
XDD1_RS01685	COG0456	acetyltransferase
XDD1_RS01690	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
XDD1_RS01695	COG2244	polysaccharide biosynthetic process
XDD1_RS01700	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
XDD1_RS01710	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
XDD1_RS01740	COG3071	HemY protein
XDD1_RS01745	COG2959	enzyme of heme biosynthesis
XDD1_RS01755	COG0181	hydroxymethylbilane synthase activity
XDD1_RS01765	COG1965	Belongs to the frataxin family
XDD1_RS01775	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
XDD1_RS01790	COG1011	Hydrolase
XDD1_RS01800	COG0598	Magnesium transport protein CorA
XDD1_RS01820	COG2050	protein possibly involved in aromatic compounds catabolism
XDD1_RS01830	COG0514	ATP-dependent DNA helicase (RecQ)
XDD1_RS01835	COG2267	carboxylic ester hydrolase activity
XDD1_RS01840	COG0561	phosphatase activity
XDD1_RS01845	COG0477	Major facilitator Superfamily
XDD1_RS01850	COG1609	Transcriptional regulator
XDD1_RS01865	COG3152	Membrane
XDD1_RS01870	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
XDD1_RS01890	COG2814	Major facilitator Superfamily
XDD1_RS01900	COG1511	domain protein
XDD1_RS01900	COG3264	Mechanosensitive ion channel
XDD1_RS01905	COG0688	phosphatidylethanolamine metabolic process
XDD1_RS01910	COG1162	GTPase activity
XDD1_RS01930	COG2814	Major facilitator Superfamily
XDD1_RS01970	COG0583	DNA-binding transcription factor activity
XDD1_RS01975	COG0477	Major facilitator Superfamily
XDD1_RS01985	COG3033	Beta-eliminating lyase
XDD1_RS01990	COG1960	acyl-CoA dehydrogenase activity
XDD1_RS01995	COG2368	4-hydroxyphenylacetate
XDD1_RS02000	COG0802	atpase or kinase
XDD1_RS02005	COG0860	N-Acetylmuramoyl-L-alanine amidase
XDD1_RS02010	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
XDD1_RS02015	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
XDD1_RS02020	COG1923	regulation of RNA biosynthetic process
XDD1_RS02025	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
XDD1_RS02030	COG0330	HflC and HflK could
XDD1_RS02035	COG0330	HflC and HflK could
XDD1_RS02040	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
XDD1_RS02055	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
XDD1_RS02060	COG0360	Binds together with S18 to 16S ribosomal RNA
XDD1_RS02065	COG2965	DNA replication, synthesis of RNA primer
XDD1_RS02070	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
XDD1_RS02075	COG0359	binds to the 23S rRNA
XDD1_RS02090	COG0545	Peptidyl-prolyl cis-trans isomerase
XDD1_RS02100	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
XDD1_RS02110	COG1598	PFAM Uncharacterised protein family UPF0150
XDD1_RS02115	COG1724	mRNA binding
XDD1_RS02120	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
XDD1_RS02135	COG2105	PFAM AIG2 family protein
XDD1_RS02145	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
XDD1_RS02150	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
XDD1_RS02155	COG1438	arginine binding
XDD1_RS02160	COG0039	L-malate dehydrogenase activity
XDD1_RS02165	COG3423	Transcriptional regulator
XDD1_RS02180	COG0142	geranyltranstransferase activity
XDD1_RS02185	COG0261	This protein binds to 23S rRNA in the presence of protein L20
XDD1_RS02190	COG0211	Belongs to the bacterial ribosomal protein bL27 family
XDD1_RS02195	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
XDD1_RS02205	COG3609	addiction module antidote protein, CC2985 family
XDD1_RS02210	COG2027	D-alanyl-D-alanine carboxypeptidase
XDD1_RS02220	COG1534	Rna-binding protein
XDD1_RS02225	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
XDD1_RS02235	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
XDD1_RS02240	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
XDD1_RS02245	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
XDD1_RS02260	COG0779	Required for maturation of 30S ribosomal subunits
XDD1_RS02265	COG0195	Participates in both transcription termination and antitermination
XDD1_RS02270	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
XDD1_RS02275	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
XDD1_RS02280	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
XDD1_RS02285	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
XDD1_RS02300	COG0513	Belongs to the DEAD box helicase family
XDD1_RS02315	COG3275	phosphorelay sensor kinase activity
XDD1_RS02320	COG1470	cell adhesion involved in biofilm formation
XDD1_RS02320	COG1388	LysM domain
XDD1_RS02325	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XDD1_RS02340	COG3154	lipid carrier protein
XDD1_RS02345	COG3153	acetyltransferase
XDD1_RS02360	COG3787	Belongs to the UPF0306 family
XDD1_RS02365	COG0602	queuosine metabolic process
XDD1_RS02380	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
XDD1_RS02385	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
XDD1_RS02420	COG0540	Belongs to the ATCase OTCase family
XDD1_RS02430	COG1234	tRNA 3'-trailer cleavage
XDD1_RS02450	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
XDD1_RS02455	COG0765	amino acid transport
XDD1_RS02460	COG1126	abc transporter atp-binding protein
XDD1_RS02465	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
XDD1_RS02470	COG2828	Protein conserved in bacteria
XDD1_RS02490	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
XDD1_RS02495	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
XDD1_RS02505	COG1757	Na H antiporter
XDD1_RS02510	COG2515	1-aminocyclopropane-1-carboxylate deaminase
XDD1_RS02520	COG3335	DDE superfamily endonuclease
XDD1_RS02555	COG5464	transposase or invertase
XDD1_RS02585	COG3335	DDE superfamily endonuclease
XDD1_RS02605	COG2873	o-acetylhomoserine
XDD1_RS02615	COG2337	Toxic component of a toxin-antitoxin (TA) module
XDD1_RS02620	COG2336	PFAM SpoVT AbrB
XDD1_RS02625	COG5464	transposase or invertase
XDD1_RS02650	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
XDD1_RS02655	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
XDD1_RS02670	COG0488	(ABC) transporter
XDD1_RS02745	COG0179	Fumarylacetoacetate (FAA) hydrolase
XDD1_RS02750	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
XDD1_RS02780	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
XDD1_RS02785	COG1518	maintenance of DNA repeat elements
XDD1_RS02815	COG1203	CRISPR-associated helicase, Cas3
XDD1_RS02825	COG1609	Transcriptional regulator
XDD1_RS02830	COG3265	gluconokinase activity
XDD1_RS02835	COG2610	gluconate transmembrane transporter activity
XDD1_RS02860	COG1696	Membrane protein involved in D-alanine export
XDD1_RS02865	COG3335	DDE superfamily endonuclease
XDD1_RS02875	COG2992	FlgJ-related protein
XDD1_RS02885	COG1028	Short-chain dehydrogenase reductase Sdr
XDD1_RS02930	COG1358	cellular component organization or biogenesis
XDD1_RS02945	COG2862	Uncharacterized protein family, UPF0114
XDD1_RS02955	COG2382	esterase
XDD1_RS02960	COG0697	spore germination
XDD1_RS02980	COG1309	transcriptional regulator
XDD1_RS02985	COG4232	protein-disulfide reductase activity
XDD1_RS02990	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
XDD1_RS02995	COG1027	Aspartate ammonia-lyase
XDD1_RS03010	COG0459	protein refolding
XDD1_RS03020	COG1509	lysine 2,3-aminomutase activity
XDD1_RS03025	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
XDD1_RS03030	COG2076	Multidrug Resistance protein
XDD1_RS03035	COG3423	Transcriptional regulator
XDD1_RS03050	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XDD1_RS03060	COG1012	belongs to the aldehyde dehydrogenase family
XDD1_RS03080	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
XDD1_RS03090	COG0795	lipopolysaccharide-transporting ATPase activity
XDD1_RS03095	COG0795	lipopolysaccharide-transporting ATPase activity
XDD1_RS03100	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
XDD1_RS03105	COG2927	DNA polymerase III (CHI subunit)
XDD1_RS03110	COG0525	valine-tRNA ligase activity
XDD1_RS03145	COG1280	lysine exporter protein (LysE YggA)
XDD1_RS03150	COG1309	transcriptional regulator
XDD1_RS03160	COG3335	DDE superfamily endonuclease
XDD1_RS03170	COG1396	sequence-specific DNA binding
XDD1_RS03195	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
XDD1_RS03200	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
XDD1_RS03205	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
XDD1_RS03230	COG0488	(ABC) transporter
XDD1_RS03240	COG1177	transmembrane transport
XDD1_RS03250	COG3842	ATPase activity
XDD1_RS03270	COG2205	protein histidine kinase activity
XDD1_RS03275	COG3727	T/G mismatch-specific endonuclease activity
XDD1_RS03290	COG3093	addiction module antidote protein HigA
XDD1_RS03300	COG0583	DNA-binding transcription factor activity
XDD1_RS03305	COG1301	dicarboxylic acid transport
XDD1_RS03320	COG3335	DDE superfamily endonuclease
XDD1_RS03325	COG1401	restriction endodeoxyribonuclease activity
XDD1_RS03345	COG2813	Specifically methylates the guanine in position
XDD1_RS03350	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
XDD1_RS03355	COG0456	acetyltransferase
XDD1_RS03360	COG3620	sequence-specific DNA binding
XDD1_RS03365	COG3550	peptidyl-serine autophosphorylation
XDD1_RS03370	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
XDD1_RS03380	COG4667	esterase of the alpha-beta hydrolase superfamily
XDD1_RS03385	COG0084	hydrolase, TatD family'
XDD1_RS03390	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
XDD1_RS03395	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
XDD1_RS03400	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
XDD1_RS03405	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
XDD1_RS03410	COG0813	purine-nucleoside phosphorylase activity
XDD1_RS03415	COG3539	Fimbrial protein
XDD1_RS03420	COG3188	usher protein
XDD1_RS03425	COG3121	Chaperone
XDD1_RS03450	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
XDD1_RS03460	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
XDD1_RS03485	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
XDD1_RS03490	COG1047	Peptidyl-prolyl cis-trans
XDD1_RS03495	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
XDD1_RS03500	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
XDD1_RS03505	COG0196	riboflavin kinase activity
XDD1_RS03510	COG0268	Binds directly to 16S ribosomal RNA
XDD1_RS03515	COG0583	DNA-binding transcription factor activity
XDD1_RS03520	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
XDD1_RS03530	COG0484	heat shock protein binding
XDD1_RS03535	COG0443	Heat shock 70 kDa protein
XDD1_RS03540	COG1584	GPR1 FUN34 yaaH family protein
XDD1_RS03555	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
XDD1_RS03605	COG0521	Mo-molybdopterin cofactor biosynthetic process
XDD1_RS03610	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
XDD1_RS03615	COG3022	response to hydroperoxide
XDD1_RS03625	COG0083	homoserine kinase activity
XDD1_RS03635	COG0745	RESPONSE REGULATOR receiver
XDD1_RS03640	COG3045	CreA protein
XDD1_RS03645	COG2207	Transcriptional regulator
XDD1_RS03645	COG3708	Transcriptional regulator
XDD1_RS03650	COG0406	alpha-ribazole phosphatase activity
XDD1_RS03655	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
XDD1_RS03660	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
XDD1_RS03665	COG0741	lytic transglycosylase activity
XDD1_RS03670	COG0488	(ABC) transporter
XDD1_RS03675	COG1126	abc transporter atp-binding protein
XDD1_RS03685	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
XDD1_RS03690	COG0560	Phosphoserine phosphatase
XDD1_RS03695	COG3726	membrane protein affecting hemolysin expression
XDD1_RS03705	COG0656	L-ascorbic acid biosynthetic process
XDD1_RS03720	COG0811	peptide transport
XDD1_RS03725	COG0848	biopolymer transport protein
XDD1_RS03740	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
XDD1_RS03745	COG2723	6-phospho-beta-galactosidase activity
XDD1_RS03755	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
XDD1_RS03780	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
XDD1_RS03785	COG2974	May be involved in recombination
XDD1_RS03790	COG1940	carbohydrate kinase activity
XDD1_RS03795	COG0737	Belongs to the 5'-nucleotidase family
XDD1_RS03835	COG0419	ATPase involved in DNA repair
XDD1_RS03840	COG0420	3'-5' exonuclease activity
XDD1_RS03845	COG0745	RESPONSE REGULATOR receiver
XDD1_RS03850	COG5002	protein histidine kinase activity
XDD1_RS03860	COG0733	neurotransmitter:sodium symporter activity
XDD1_RS03870	COG0450	alkyl hydroperoxide reductase
XDD1_RS03875	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
XDD1_RS03880	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
XDD1_RS03885	COG0343	queuine tRNA-ribosyltransferase activity
XDD1_RS03890	COG1862	Preprotein translocase
XDD1_RS03900	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
XDD1_RS03905	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
XDD1_RS03910	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
XDD1_RS03910	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
XDD1_RS03915	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
XDD1_RS03920	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
XDD1_RS03925	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
XDD1_RS03930	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
XDD1_RS03935	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
XDD1_RS03955	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
XDD1_RS03960	COG1757	Na H antiporter
XDD1_RS03965	COG1609	Transcriptional regulator
XDD1_RS03995	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
XDD1_RS04000	COG0142	geranyltranstransferase activity
XDD1_RS04010	COG0301	tRNA thio-modification
XDD1_RS04010	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
XDD1_RS04015	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
XDD1_RS04020	COG1666	GTP binding
XDD1_RS04025	COG2814	Major facilitator Superfamily
XDD1_RS04030	COG0109	protoheme IX farnesyltransferase activity
XDD1_RS04035	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
XDD1_RS04040	COG1845	cytochrome c oxidase, subunit III
XDD1_RS04045	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
XDD1_RS04050	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
XDD1_RS04060	COG2223	nitrite transmembrane transporter activity
XDD1_RS04065	COG3056	Lipoprotein
XDD1_RS04070	COG0271	Belongs to the BolA IbaG family
XDD1_RS04080	COG0740	serine-type endopeptidase activity
XDD1_RS04085	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
XDD1_RS04090	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
XDD1_RS04100	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
XDD1_RS04105	COG1555	photosystem II stabilization
XDD1_RS04110	COG0824	Thioesterase
XDD1_RS04115	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
XDD1_RS04125	COG1522	sequence-specific DNA binding
XDD1_RS04130	COG1132	(ABC) transporter
XDD1_RS04135	COG1132	(ABC) transporter
XDD1_RS04140	COG0347	Belongs to the P(II) protein family
XDD1_RS04145	COG0004	ammonium transporteR
XDD1_RS04150	COG1946	Acyl-CoA thioesterase
XDD1_RS04170	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XDD1_RS04175	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XDD1_RS04180	COG1309	transcriptional regulator
XDD1_RS04185	COG1196	nuclear chromosome segregation
XDD1_RS04185	COG3264	Mechanosensitive ion channel
XDD1_RS04195	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
XDD1_RS04205	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
XDD1_RS04210	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
XDD1_RS04215	COG0326	Molecular chaperone. Has ATPase activity
XDD1_RS04220	COG0563	adenylate kinase activity
XDD1_RS04225	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
XDD1_RS04230	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
XDD1_RS04235	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
XDD1_RS04240	COG4651	solute:proton antiporter activity
XDD1_RS04240	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
XDD1_RS04245	COG2223	nitrite transmembrane transporter activity
XDD1_RS04250	COG0737	Belongs to the 5'-nucleotidase family
XDD1_RS04265	COG3735	TraB family
XDD1_RS04270	COG2217	Heavy metal translocating P-type atpase
XDD1_RS04275	COG0789	Transcriptional regulator
XDD1_RS04280	COG1585	Membrane protein implicated in regulation of membrane protease activity
XDD1_RS04285	COG0330	HflC and HflK could
XDD1_RS04290	COG3118	belongs to the thioredoxin family
XDD1_RS04295	COG0300	oxidoreductase activity
XDD1_RS04300	COG2755	lipolytic protein G-D-S-L family
XDD1_RS04305	COG4181	ATPase activity
XDD1_RS04310	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
XDD1_RS04320	COG0307	riboflavin synthase, alpha
XDD1_RS04335	COG0446	pyridine nucleotide-disulphide oxidoreductase
XDD1_RS04345	COG3555	Aspartyl Asparaginyl beta-hydroxylase
XDD1_RS04350	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
XDD1_RS04355	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
XDD1_RS04360	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XDD1_RS04365	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
XDD1_RS04380	COG0215	cysteine-tRNA ligase activity
XDD1_RS04385	COG2501	S4 domain
XDD1_RS04390	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
XDD1_RS04445	COG3657	addiction module killer protein
XDD1_RS04450	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
XDD1_RS04465	COG3209	COG3209 Rhs family protein
XDD1_RS04500	COG3209	COG3209 Rhs family protein
XDD1_RS04515	COG3501	Rhs element vgr protein
XDD1_RS04545	COG0741	lytic transglycosylase activity
XDD1_RS04545	COG1388	LysM domain
XDD1_RS04550	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
XDD1_RS04555	COG2226	methyltransferase
XDD1_RS04585	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
XDD1_RS04590	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
XDD1_RS04610	COG3104	oligopeptide transport
XDD1_RS04625	COG0259	pyridoxamine-phosphate oxidase activity
XDD1_RS04635	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
XDD1_RS04660	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
XDD1_RS04665	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
XDD1_RS04680	COG1063	alcohol dehydrogenase
XDD1_RS04685	COG1454	alcohol dehydrogenase
XDD1_RS04690	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
XDD1_RS04695	COG2368	4-hydroxyphenylacetate
XDD1_RS04725	COG3971	2-oxopent-4-enoate hydratase activity
XDD1_RS04740	COG3384	dioxygenase
XDD1_RS04745	COG1012	belongs to the aldehyde dehydrogenase family
XDD1_RS04755	COG0179	Fumarylacetoacetate (FAA) hydrolase
XDD1_RS04760	COG1846	Transcriptional regulator
XDD1_RS04800	COG3962	Belongs to the TPP enzyme family
XDD1_RS04810	COG0673	inositol 2-dehydrogenase activity
XDD1_RS04815	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
XDD1_RS04820	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
XDD1_RS04830	COG3718	enzyme involved in inositol metabolism
XDD1_RS04860	COG1335	isochorismatase
XDD1_RS04875	COG3423	Transcriptional regulator
XDD1_RS04880	COG2267	carboxylic ester hydrolase activity
XDD1_RS04885	COG0697	spore germination
XDD1_RS04930	COG0305	Participates in initiation and elongation during chromosome replication
XDD1_RS04960	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
XDD1_RS04985	COG3423	Transcriptional regulator
XDD1_RS05080	COG1388	LysM domain
XDD1_RS05080	COG1470	cell adhesion involved in biofilm formation
XDD1_RS05085	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
XDD1_RS05085	COG1522	sequence-specific DNA binding
XDD1_RS05130	COG3209	COG3209 Rhs family protein
XDD1_RS05130	COG4104	PAAR repeat-containing protein
XDD1_RS05140	COG3501	Rhs element vgr protein
XDD1_RS05155	COG2831	hemolysin activation secretion protein
XDD1_RS05165	COG3210	domain, Protein
XDD1_RS05230	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
XDD1_RS05240	COG0741	lytic transglycosylase activity
XDD1_RS05245	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
XDD1_RS05250	COG1194	a g-specific adenine glycosylase
XDD1_RS05255	COG0220	tRNA (guanine-N7-)-methyltransferase activity
XDD1_RS05260	COG3171	Protein conserved in bacteria
XDD1_RS05265	COG2066	Belongs to the glutaminase family
XDD1_RS05275	COG4607	ABC-type enterochelin transport system periplasmic component
XDD1_RS05285	COG1881	PFAM PEBP family protein
XDD1_RS05295	COG0583	DNA-binding transcription factor activity
XDD1_RS05300	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
XDD1_RS05305	COG0066	3-isopropylmalate dehydratase activity
XDD1_RS05330	COG0635	Involved in the biosynthesis of porphyrin-containing compound
XDD1_RS05335	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
XDD1_RS05340	COG0762	integral membrane protein
XDD1_RS05345	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
XDD1_RS05350	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
XDD1_RS05355	COG2805	Type II/IV secretion system protein
XDD1_RS05360	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
XDD1_RS05365	COG1678	Uncharacterized ACR, COG1678
XDD1_RS05370	COG0189	ligase activity
XDD1_RS05375	COG1385	rRNA (uridine-N3-)-methyltransferase activity
XDD1_RS05390	COG0583	DNA-binding transcription factor activity
XDD1_RS05395	COG0583	DNA-binding transcription factor activity
XDD1_RS05405	COG1960	acyl-CoA dehydrogenase activity
XDD1_RS05415	COG0121	glutamine amidotransferase
XDD1_RS05420	COG3034	peptidoglycan biosynthetic process
XDD1_RS05425	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
XDD1_RS05430	COG1805	sodium ion transport
XDD1_RS05435	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
XDD1_RS05440	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
XDD1_RS05445	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
XDD1_RS05455	COG1477	protein flavinylation
XDD1_RS05460	COG2991	Protein conserved in bacteria
XDD1_RS05465	COG1595	DNA-templated transcription, initiation
XDD1_RS05470	COG1629	transport
XDD1_RS05480	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
XDD1_RS05485	COG1012	belongs to the aldehyde dehydrogenase family
XDD1_RS05490	COG1309	transcriptional regulator
XDD1_RS05495	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
XDD1_RS05505	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
XDD1_RS05510	COG2195	Cleaves the N-terminal amino acid of tripeptides
XDD1_RS05515	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
XDD1_RS05520	COG1073	alpha beta
XDD1_RS05530	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
XDD1_RS05535	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
XDD1_RS05545	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
XDD1_RS05550	COG0318	PFAM AMP-dependent synthetase and ligase
XDD1_RS05550	COG0204	Acyl-transferase
XDD1_RS05555	COG2814	Major facilitator Superfamily
XDD1_RS05565	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
XDD1_RS05570	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
XDD1_RS05575	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
XDD1_RS05595	COG2918	glutathione biosynthetic process
XDD1_RS05605	COG4536	flavin adenine dinucleotide binding
XDD1_RS05610	COG4137	Cytochrome C assembly protein
XDD1_RS05615	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
XDD1_RS05620	COG0228	four-way junction DNA binding
XDD1_RS05625	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
XDD1_RS05630	COG0336	Belongs to the RNA methyltransferase TrmD family
XDD1_RS05635	COG0335	large ribosomal subunit rRNA binding
XDD1_RS05640	COG0165	Argininosuccinate lyase
XDD1_RS05645	COG2814	Major facilitator Superfamily
XDD1_RS05660	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
XDD1_RS05665	COG0287	Prephenate dehydrogenase
XDD1_RS05665	COG1605	Chorismate mutase
XDD1_RS05670	COG1605	Chorismate mutase
XDD1_RS05670	COG0077	Prephenate dehydratase
XDD1_RS05675	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
XDD1_RS05680	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XDD1_RS05685	COG0564	pseudouridine synthase activity
XDD1_RS05690	COG1496	oxidoreductase activity
XDD1_RS05695	COG0542	response to heat
XDD1_RS05720	COG5544	Lipoprotein
XDD1_RS05725	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XDD1_RS05730	COG1042	CoA-binding domain protein
XDD1_RS05730	COG0045	succinate-CoA ligase (ADP-forming) activity
XDD1_RS05730	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
XDD1_RS05735	COG3148	PFAM DTW domain containing protein
XDD1_RS05740	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
XDD1_RS05760	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
XDD1_RS05765	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
XDD1_RS05770	COG1120	ATPase activity
XDD1_RS05775	COG4114	ferric iron reductase
XDD1_RS05780	COG0076	glutamate decarboxylase activity
XDD1_RS05785	COG3486	L-lysine 6-monooxygenase (NADPH) activity
XDD1_RS05795	COG2814	Major facilitator Superfamily
XDD1_RS05800	COG1566	PFAM secretion protein HlyD family protein
XDD1_RS05805	COG1846	Transcriptional regulator
XDD1_RS05815	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
XDD1_RS05820	COG2113	Glycine betaine
XDD1_RS05825	COG4176	ABC-type proline glycine betaine transport system permease component
XDD1_RS05830	COG4175	Glycine betaine
XDD1_RS05840	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
XDD1_RS05845	COG1278	Cold shock
XDD1_RS05850	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
XDD1_RS05855	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
XDD1_RS05860	COG0321	lipoyl(octanoyl) transferase activity
XDD1_RS05870	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
XDD1_RS05875	COG2921	Belongs to the UPF0250 family
XDD1_RS05880	COG1686	Belongs to the peptidase S11 family
XDD1_RS05890	COG0772	Belongs to the SEDS family
XDD1_RS05895	COG0768	penicillin binding
XDD1_RS05900	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
XDD1_RS05905	COG0799	negative regulation of ribosome biogenesis
XDD1_RS05915	COG1466	dna polymerase III delta subunit
XDD1_RS05920	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
XDD1_RS05925	COG0495	leucyl-tRNA aminoacylation
XDD1_RS05930	COG1126	abc transporter atp-binding protein
XDD1_RS05935	COG0765	amino acid transport
XDD1_RS05940	COG0765	amino acid transport
XDD1_RS05960	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
XDD1_RS05975	COG0815	Transfers the fatty acyl group on membrane lipoproteins
XDD1_RS05980	COG4535	Mg2 and Co2 transporter CorC
XDD1_RS05985	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
XDD1_RS05990	COG1702	phosphate starvation-inducible protein PhoH
XDD1_RS05995	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
XDD1_RS06000	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XDD1_RS06040	COG1940	carbohydrate kinase activity
XDD1_RS06040	COG1846	Transcriptional regulator
XDD1_RS06045	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
XDD1_RS06050	COG0363	glucosamine-6-phosphate deaminase activity
XDD1_RS06055	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
XDD1_RS06055	COG1263	PTS System
XDD1_RS06055	COG2190	(PTS) system
XDD1_RS06060	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
XDD1_RS06070	COG0735	belongs to the Fur family
XDD1_RS06075	COG0716	FMN binding
XDD1_RS06095	COG0662	Cupin 2, conserved barrel domain protein
XDD1_RS06095	COG2207	Transcriptional regulator
XDD1_RS06100	COG2274	protein secretion by the type I secretion system
XDD1_RS06125	COG2994	toxin metabolic process
XDD1_RS06130	COG3064	Membrane
XDD1_RS06130	COG1073	alpha beta
XDD1_RS06130	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
XDD1_RS06145	COG2226	methyltransferase
XDD1_RS06165	COG2226	methyltransferase
XDD1_RS06170	COG0596	Alpha beta hydrolase
XDD1_RS06175	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
XDD1_RS06180	COG0033	Phosphoglucomutase
XDD1_RS06195	COG2205	protein histidine kinase activity
XDD1_RS06200	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
XDD1_RS06205	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
XDD1_RS06210	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
XDD1_RS06220	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
XDD1_RS06225	COG2814	Major facilitator Superfamily
XDD1_RS06235	COG0372	Belongs to the citrate synthase family
XDD1_RS06245	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
XDD1_RS06255	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
XDD1_RS06260	COG0567	Dehydrogenase, E1 component
XDD1_RS06265	COG0508	dehydrogenase complex catalyzes the overall conversion of
XDD1_RS06270	COG0045	succinate-CoA ligase (ADP-forming) activity
XDD1_RS06275	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
XDD1_RS06280	COG1271	oxidase subunit
XDD1_RS06285	COG1294	oxidase, subunit
XDD1_RS06290	COG3790	cyd operon protein YbgE
XDD1_RS06295	COG0824	Thioesterase
XDD1_RS06300	COG0811	peptide transport
XDD1_RS06305	COG0848	biopolymer transport protein
XDD1_RS06310	COG3064	Membrane
XDD1_RS06315	COG0823	Involved in the tonB-independent uptake of proteins
XDD1_RS06320	COG2885	chlorophyll binding
XDD1_RS06325	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
XDD1_RS06360	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
XDD1_RS06365	COG0588	phosphoglycerate mutase activity
XDD1_RS06375	COG1119	ATPase activity
XDD1_RS06380	COG0725	ABC transporter, periplasmic molybdate-binding protein
XDD1_RS06385	COG4149	molybdate abc transporter
XDD1_RS06390	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
XDD1_RS06395	COG0561	phosphatase activity
XDD1_RS06400	COG2706	6-phosphogluconolactonase activity
XDD1_RS06430	COG0305	Participates in initiation and elongation during chromosome replication
XDD1_RS06465	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
XDD1_RS06490	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
XDD1_RS06495	COG3423	Transcriptional regulator
XDD1_RS06540	COG1309	transcriptional regulator
XDD1_RS06550	COG0842	Transport permease protein
XDD1_RS06555	COG0842	Transport permease protein
XDD1_RS06560	COG1131	(ABC) transporter
XDD1_RS06570	COG1309	transcriptional regulator
XDD1_RS06580	COG0513	Belongs to the DEAD box helicase family
XDD1_RS06585	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
XDD1_RS06605	COG2261	transglycosylase associated protein
XDD1_RS06610	COG2897	thiosulfate sulfurtransferase activity
XDD1_RS06620	COG0488	(ABC) transporter
XDD1_RS06640	COG2824	Alkylphosphonate utilization operon protein PhnA
XDD1_RS06650	COG5006	permease, DMT superfamily
XDD1_RS06660	COG0673	inositol 2-dehydrogenase activity
XDD1_RS06665	COG0488	(ABC) transporter
XDD1_RS06675	COG0303	'Molybdopterin
XDD1_RS06680	COG0477	Major facilitator Superfamily
XDD1_RS06685	COG0302	gtp cyclohydrolase
XDD1_RS06690	COG2311	Membrane
XDD1_RS06695	COG2949	membrane
XDD1_RS06700	COG0281	malic enzyme
XDD1_RS06705	COG0295	cytidine deaminase activity
XDD1_RS06710	COG1346	cytolysis
XDD1_RS06715	COG1380	Effector of murein hydrolase LrgA
XDD1_RS06720	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
XDD1_RS06720	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
XDD1_RS06730	COG0572	uridine kinase
XDD1_RS06735	COG0717	Belongs to the dCTP deaminase family
XDD1_RS06740	COG2982	Protein involved in outer membrane biogenesis
XDD1_RS06800	COG2826	transposase and inactivated derivatives, IS30 family
XDD1_RS06810	COG0670	Belongs to the BI1 family
XDD1_RS06815	COG0314	molybdopterin synthase activity
XDD1_RS06820	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
XDD1_RS06830	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
XDD1_RS06835	COG0391	Required for morphogenesis under gluconeogenic growth conditions
XDD1_RS06840	COG0556	nucleotide-excision repair
XDD1_RS06845	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
XDD1_RS06850	COG2226	methyltransferase
XDD1_RS06855	COG0156	8-amino-7-oxononanoate synthase activity
XDD1_RS06860	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
XDD1_RS06905	COG3209	COG3209 Rhs family protein
XDD1_RS06920	COG3620	sequence-specific DNA binding
XDD1_RS06925	COG0358	DNA primase activity
XDD1_RS06930	COG4974	Belongs to the 'phage' integrase family
XDD1_RS06945	COG3335	DDE superfamily endonuclease
XDD1_RS06990	COG1522	sequence-specific DNA binding
XDD1_RS06990	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
XDD1_RS07020	COG1253	flavin adenine dinucleotide binding
XDD1_RS07025	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
XDD1_RS07030	COG1454	alcohol dehydrogenase
XDD1_RS07035	COG0140	phosphoribosyl-ATP diphosphatase activity
XDD1_RS07035	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
XDD1_RS07040	COG0107	imidazoleglycerol-phosphate synthase activity
XDD1_RS07045	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
XDD1_RS07050	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
XDD1_RS07055	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
XDD1_RS07055	COG0131	Imidazoleglycerol-phosphate dehydratase
XDD1_RS07060	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
XDD1_RS07060	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
XDD1_RS07065	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
XDD1_RS07065	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
XDD1_RS07070	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
XDD1_RS07075	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
XDD1_RS07080	COG0625	glutathione transferase activity
XDD1_RS07085	COG1686	Belongs to the peptidase S11 family
XDD1_RS07090	COG0814	amino acid
XDD1_RS07095	COG0671	phosphoesterase, PA-phosphatase related
XDD1_RS07115	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
XDD1_RS07120	COG4160	amino acid transport
XDD1_RS07125	COG4215	(ABC) transporter
XDD1_RS07130	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
XDD1_RS07135	COG1126	abc transporter atp-binding protein
XDD1_RS07140	COG2431	L-lysine efflux transmembrane transporter activity
XDD1_RS07145	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XDD1_RS07150	COG0577	efflux transmembrane transporter activity
XDD1_RS07150	COG1136	(ABC) transporter
XDD1_RS07155	COG1278	Cold shock
XDD1_RS07160	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
XDD1_RS07165	COG0542	response to heat
XDD1_RS07175	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
XDD1_RS07180	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
XDD1_RS07190	COG0492	ferredoxin-NADP+ reductase activity
XDD1_RS07195	COG1522	sequence-specific DNA binding
XDD1_RS07200	COG1674	ftsk spoiiie
XDD1_RS07200	COG3107	peptidoglycan biosynthetic process
XDD1_RS07205	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
XDD1_RS07210	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
XDD1_RS07215	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
XDD1_RS07230	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
XDD1_RS07235	COG1882	Formate acetyltransferase
XDD1_RS07240	COG2116	formate transmembrane transporter activity
XDD1_RS07245	COG1944	ATP diphosphatase activity
XDD1_RS07250	COG0252	asparaginase activity
XDD1_RS07255	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
XDD1_RS07260	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
XDD1_RS07265	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
XDD1_RS07270	COG0539	negative regulation of cytoplasmic translation
XDD1_RS07280	COG0658	competence protein
XDD1_RS07280	COG2333	competence protein COMEC
XDD1_RS07285	COG1132	(ABC) transporter
XDD1_RS07290	COG1663	tetraacyldisaccharide 4'-kinase activity
XDD1_RS07295	COG2835	tetraacyldisaccharide 4'-kinase activity
XDD1_RS07300	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
XDD1_RS07305	COG1434	Gram-negative-bacterium-type cell wall biogenesis
XDD1_RS07310	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
XDD1_RS07315	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
XDD1_RS07320	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
XDD1_RS07325	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
XDD1_RS07330	COG3700	Belongs to the class B bacterial acid phosphatase family
XDD1_RS07335	COG2989	Protein conserved in bacteria
XDD1_RS07340	COG3108	Peptidase M15
XDD1_RS07345	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
XDD1_RS07350	COG1448	Aminotransferase
XDD1_RS07355	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
XDD1_RS07360	COG0017	Asparaginyl-tRNA synthetase
XDD1_RS07365	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
XDD1_RS07370	COG0308	aminopeptidase N
XDD1_RS07375	COG0167	dihydroorotate dehydrogenase activity
XDD1_RS07385	COG3217	Mosc domain protein beta barrel domain protein
XDD1_RS07385	COG0633	Ferredoxin
XDD1_RS07390	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
XDD1_RS07390	COG0116	Belongs to the methyltransferase superfamily
XDD1_RS07395	COG0488	(ABC) transporter
XDD1_RS07400	COG2995	paraquat-inducible protein a
XDD1_RS07405	COG3008	intermembrane lipid transfer
XDD1_RS07405	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
XDD1_RS07410	COG3009	Protein conserved in bacteria
XDD1_RS07415	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
XDD1_RS07420	COG1067	ATP-dependent peptidase activity
XDD1_RS07425	COG3120	sequence-specific DNA binding
XDD1_RS07435	COG5404	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
XDD1_RS07540	COG1289	transmembrane transporter activity
XDD1_RS07545	COG0210	DNA helicase
XDD1_RS07550	COG1832	CoA-binding protein
XDD1_RS07555	COG3785	DNA binding
XDD1_RS07560	COG1254	Belongs to the acylphosphatase family
XDD1_RS07565	COG2920	part of a sulfur-relay system
XDD1_RS07580	COG4104	PAAR repeat-containing protein
XDD1_RS07605	COG1802	Transcriptional regulator
XDD1_RS07605	COG4626	Terminase
XDD1_RS07610	COG3423	Transcriptional regulator
XDD1_RS07630	COG0183	Belongs to the thiolase family
XDD1_RS07635	COG0667	Aldo Keto reductase
XDD1_RS07655	COG1113	amino acid transport
XDD1_RS07675	COG2826	transposase and inactivated derivatives, IS30 family
XDD1_RS07695	COG0583	DNA-binding transcription factor activity
XDD1_RS07700	COG0697	spore germination
XDD1_RS07715	COG2197	response regulator
XDD1_RS07720	COG0322	excinuclease ABC activity
XDD1_RS07725	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
XDD1_RS07745	COG0582	viral genome integration into host DNA
XDD1_RS07820	COG4626	Terminase
XDD1_RS07820	COG1802	Transcriptional regulator
XDD1_RS07825	COG3423	Transcriptional regulator
XDD1_RS07845	COG4682	membrane
XDD1_RS07880	COG3545	Serine hydrolase
XDD1_RS07890	COG1304	FMN binding
XDD1_RS07920	COG1560	Kdo2-lipid A biosynthetic process
XDD1_RS07930	COG0501	Belongs to the peptidase M48B family
XDD1_RS07945	COG2197	response regulator
XDD1_RS07955	COG2271	Major facilitator Superfamily
XDD1_RS07960	COG2226	methyltransferase
XDD1_RS07965	COG1971	Probably functions as a manganese efflux pump
XDD1_RS07970	COG4811	Protein of unknown function (DUF986)
XDD1_RS07975	COG3716	PTS system mannose fructose sorbose family IID component
XDD1_RS07980	COG3715	PTS system
XDD1_RS07985	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
XDD1_RS07985	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
XDD1_RS07990	COG1760	l-serine dehydratase
XDD1_RS07995	COG0494	nUDIX hydrolase
XDD1_RS08005	COG3140	Belongs to the UPF0181 family
XDD1_RS08035	COG1528	Iron-storage protein
XDD1_RS08040	COG2372	response to copper ion
XDD1_RS08045	COG1276	copper resistance
XDD1_RS08055	COG1956	GAF domain-containing protein
XDD1_RS08060	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
XDD1_RS08070	COG0501	Belongs to the peptidase M48B family
XDD1_RS08075	COG1823	symporter activity
XDD1_RS08080	COG1988	membrane-bound metal-dependent
XDD1_RS08090	COG3001	Fructosamine kinase
XDD1_RS08095	COG1108	ABC-type Mn2 Zn2 transport systems permease components
XDD1_RS08100	COG1108	ABC-type Mn2 Zn2 transport systems permease components
XDD1_RS08105	COG1121	(ABC) transporter
XDD1_RS08110	COG0803	Belongs to the bacterial solute-binding protein 9 family
XDD1_RS08165	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
XDD1_RS08170	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
XDD1_RS08175	COG0291	Belongs to the bacterial ribosomal protein bL35 family
XDD1_RS08190	COG0072	phenylalanine-tRNA ligase activity
XDD1_RS08190	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
XDD1_RS08195	COG0776	regulation of translation
XDD1_RS08200	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
XDD1_RS08205	COG0463	Glycosyl transferase, family 2
XDD1_RS08210	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
XDD1_RS08210	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
XDD1_RS08215	COG0726	polysaccharide deacetylase
XDD1_RS08220	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
XDD1_RS08225	COG2076	Multidrug Resistance protein
XDD1_RS08230	COG2076	Multidrug Resistance protein
XDD1_RS08235	COG0791	NLP P60 protein
XDD1_RS08260	COG1250	3-hydroxyacyl-CoA dehydrogenase
XDD1_RS08280	COG4221	oxidoreductase activity
XDD1_RS08280	COG3321	synthase
XDD1_RS08280	COG1028	Short-chain dehydrogenase reductase Sdr
XDD1_RS08280	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
XDD1_RS08325	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
XDD1_RS08330	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
XDD1_RS08335	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
XDD1_RS08340	COG4558	Periplasmic binding protein
XDD1_RS08345	COG3720	iron ion transport
XDD1_RS08355	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
XDD1_RS08360	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
XDD1_RS08390	COG4974	Belongs to the 'phage' integrase family
XDD1_RS08395	COG0358	DNA primase activity
XDD1_RS08400	COG1476	TRANSCRIPTIONal
XDD1_RS08430	COG4974	Belongs to the 'phage' integrase family
XDD1_RS08440	COG0358	DNA primase activity
XDD1_RS08480	COG4974	Belongs to the 'phage' integrase family
XDD1_RS08490	COG0358	DNA primase activity
XDD1_RS08520	COG0574	Belongs to the PEP-utilizing enzyme family
XDD1_RS08520	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
XDD1_RS08525	COG0628	permease
XDD1_RS08530	COG0247	lactate metabolic process
XDD1_RS08530	COG0277	FAD linked oxidase domain protein
XDD1_RS08535	COG2050	protein possibly involved in aromatic compounds catabolism
XDD1_RS08540	COG1388	LysM domain
XDD1_RS08540	COG1376	ErfK ybiS ycfS ynhG family protein
XDD1_RS08545	COG4238	major outer membrane lipoprotein
XDD1_RS08565	COG0534	Mate efflux family protein
XDD1_RS08570	COG0307	riboflavin synthase, alpha
XDD1_RS08575	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
XDD1_RS08580	COG2814	Major facilitator Superfamily
XDD1_RS08585	COG0583	DNA-binding transcription factor activity
XDD1_RS08590	COG1609	Transcriptional regulator
XDD1_RS08600	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
XDD1_RS08605	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
XDD1_RS08610	COG0346	lactoylglutathione lyase activity
XDD1_RS08625	COG3133	Outer membrane lipoprotein
XDD1_RS08630	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
XDD1_RS08635	COG0259	pyridoxamine-phosphate oxidase activity
XDD1_RS08640	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
XDD1_RS08645	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
XDD1_RS08665	COG4171	peptide transport system, permease
XDD1_RS08675	COG4166	transmembrane transport
XDD1_RS08680	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
XDD1_RS08685	COG1842	Phage shock protein A
XDD1_RS08695	COG1983	PspC domain protein
XDD1_RS08700	COG3106	COG3106 Predicted ATPase
XDD1_RS08820	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
XDD1_RS08825	COG0598	Magnesium transport protein CorA
XDD1_RS08830	COG0037	tRNA processing
XDD1_RS08845	COG2076	Multidrug Resistance protein
XDD1_RS08855	COG0583	DNA-binding transcription factor activity
XDD1_RS08860	COG2814	Major facilitator Superfamily
XDD1_RS08865	COG0542	response to heat
XDD1_RS08880	COG3335	DDE superfamily endonuclease
XDD1_RS08895	COG1012	belongs to the aldehyde dehydrogenase family
XDD1_RS08915	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
XDD1_RS08920	COG3152	Membrane
XDD1_RS08925	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XDD1_RS08930	COG3734	2-keto-3-deoxy-galactonokinase
XDD1_RS08935	COG0800	Aldolase
XDD1_RS08945	COG2271	Major facilitator Superfamily
XDD1_RS08965	COG2814	Major facilitator Superfamily
XDD1_RS08985	COG0589	response to stress
XDD1_RS09000	COG2356	endonuclease I
XDD1_RS09025	COG3335	DDE superfamily endonuclease
XDD1_RS09060	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
XDD1_RS09070	COG4264	IucA IucC family
XDD1_RS09075	COG0019	diaminopimelate decarboxylase activity
XDD1_RS09080	COG0477	Major facilitator Superfamily
XDD1_RS09085	COG4264	IucA IucC family
XDD1_RS09095	COG4264	IucA IucC family
XDD1_RS09100	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
XDD1_RS09105	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
XDD1_RS09110	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
XDD1_RS09115	COG1120	ATPase activity
XDD1_RS09125	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
XDD1_RS09130	COG1294	oxidase, subunit
XDD1_RS09135	COG1271	oxidase subunit
XDD1_RS09145	COG1309	transcriptional regulator
XDD1_RS09155	COG0443	Heat shock 70 kDa protein
XDD1_RS09160	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
XDD1_RS09175	COG0579	oxidoreductase
XDD1_RS09205	COG2249	NAD(P)H dehydrogenase (quinone) activity
XDD1_RS09210	COG2207	Transcriptional regulator
XDD1_RS09215	COG0012	GTP binding
XDD1_RS09220	COG0193	aminoacyl-tRNA hydrolase activity
XDD1_RS09240	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
XDD1_RS09245	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
XDD1_RS09250	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
XDD1_RS09255	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
XDD1_RS09260	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
XDD1_RS09265	COG2890	protein-(glutamine-N5) methyltransferase activity
XDD1_RS09275	COG2877	3-deoxy-8-phosphooctulonate synthase activity
XDD1_RS09280	COG0659	secondary active sulfate transmembrane transporter activity
XDD1_RS09285	COG2453	phosphatase
XDD1_RS09285	COG0671	phosphoesterase, PA-phosphatase related
XDD1_RS09290	COG2267	carboxylic ester hydrolase activity
XDD1_RS09295	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
XDD1_RS09300	COG2378	regulation of single-species biofilm formation
XDD1_RS09330	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
XDD1_RS09335	COG3381	protein complex oligomerization
XDD1_RS09365	COG0477	Major facilitator Superfamily
XDD1_RS09370	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
XDD1_RS09375	COG3335	DDE superfamily endonuclease
XDD1_RS09490	COG0018	arginyl-trna synthetase
XDD1_RS09495	COG3142	Participates in the control of copper homeostasis
XDD1_RS09500	COG0500	methyltransferase
XDD1_RS09505	COG2226	methyltransferase
XDD1_RS09510	COG3788	relative of glutathione S-transferase, MAPEG superfamily
XDD1_RS09515	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
XDD1_RS09520	COG0494	nUDIX hydrolase
XDD1_RS09525	COG0217	transcriptional regulatory protein
XDD1_RS09530	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
XDD1_RS09535	COG0632	four-way junction helicase activity
XDD1_RS09540	COG2255	four-way junction helicase activity
XDD1_RS09555	COG1108	ABC-type Mn2 Zn2 transport systems permease components
XDD1_RS09560	COG1121	(ABC) transporter
XDD1_RS09565	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
XDD1_RS09570	COG0739	heme binding
XDD1_RS09575	COG1560	Kdo2-lipid A biosynthetic process
XDD1_RS09580	COG0469	pyruvate kinase activity
XDD1_RS09585	COG1737	Transcriptional regulator
XDD1_RS09590	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
XDD1_RS09595	COG2076	Multidrug Resistance protein
XDD1_RS09600	COG2076	Multidrug Resistance protein
XDD1_RS09605	COG0251	oxidation-reduction process
XDD1_RS09610	COG1199	ATP-dependent helicase activity
XDD1_RS09620	COG3065	identical protein binding
XDD1_RS09625	COG0318	PFAM AMP-dependent synthetase and ligase
XDD1_RS09630	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
XDD1_RS09635	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
XDD1_RS09640	COG2894	cell division
XDD1_RS09645	COG0850	regulation of cytokinetic process
XDD1_RS09650	COG3100	YcgL domain-containing protein
XDD1_RS09655	COG2951	lytic endotransglycosylase activity
XDD1_RS09660	COG0179	Fumarylacetoacetate (FAA) hydrolase
XDD1_RS09665	COG2983	Belongs to the UPF0260 family
XDD1_RS09680	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
XDD1_RS09685	COG2911	Protein conserved in bacteria
XDD1_RS09695	COG3784	Protein of unknown function (DUF1318)
XDD1_RS09705	COG1643	Atp-dependent helicase
XDD1_RS09720	COG3121	Chaperone
XDD1_RS09730	COG0531	amino acid
XDD1_RS09740	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
XDD1_RS09745	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
XDD1_RS09760	COG1136	(ABC) transporter
XDD1_RS09760	COG0577	efflux transmembrane transporter activity
XDD1_RS09770	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XDD1_RS09795	COG4974	Belongs to the 'phage' integrase family
XDD1_RS09820	COG3335	DDE superfamily endonuclease
XDD1_RS09825	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
XDD1_RS09855	COG0820	rRNA (adenine-C2-)-methyltransferase activity
XDD1_RS09875	COG2814	Major facilitator Superfamily
XDD1_RS09900	COG0477	Major facilitator Superfamily
XDD1_RS09915	COG0697	spore germination
XDD1_RS09925	COG4771	TonB-dependent receptor
XDD1_RS09955	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
XDD1_RS09960	COG1902	pentaerythritol trinitrate reductase activity
XDD1_RS09965	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
XDD1_RS09970	COG3118	belongs to the thioredoxin family
XDD1_RS09980	COG1917	Cupin 2, conserved barrel domain protein
XDD1_RS09980	COG2207	Transcriptional regulator
XDD1_RS09990	COG0688	phosphatidylethanolamine metabolic process
XDD1_RS10000	COG1132	(ABC) transporter
XDD1_RS10005	COG4221	oxidoreductase activity
XDD1_RS10020	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
XDD1_RS10025	COG0583	DNA-binding transcription factor activity
XDD1_RS10030	COG3335	DDE superfamily endonuclease
XDD1_RS10035	COG0583	DNA-binding transcription factor activity
XDD1_RS10040	COG2814	Major facilitator Superfamily
XDD1_RS10055	COG0114	fumarate hydratase activity
XDD1_RS10065	COG5339	Protein conserved in bacteria
XDD1_RS10070	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
XDD1_RS10075	COG0385	Bile acid
XDD1_RS10080	COG0673	inositol 2-dehydrogenase activity
XDD1_RS10090	COG4657	Part of a membrane complex involved in electron transport
XDD1_RS10100	COG4656	Part of a membrane complex involved in electron transport
XDD1_RS10110	COG4659	FMN binding
XDD1_RS10120	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
XDD1_RS10130	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
XDD1_RS10140	COG0023	Translation Initiation Factor
XDD1_RS10145	COG0284	orotidine-5'-phosphate decarboxylase activity
XDD1_RS10150	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
XDD1_RS10155	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
XDD1_RS10165	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
XDD1_RS10175	COG0583	DNA-binding transcription factor activity
XDD1_RS10190	COG0616	signal peptide processing
XDD1_RS10195	COG1028	Short-chain dehydrogenase reductase Sdr
XDD1_RS10205	COG0009	L-threonylcarbamoyladenylate synthase
XDD1_RS10225	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
XDD1_RS10235	COG0133	tryptophan synthase activity
XDD1_RS10240	COG0159	tryptophan synthase activity
XDD1_RS10245	COG3047	cAMP biosynthetic process
XDD1_RS10260	COG2917	probably involved in intracellular septation
XDD1_RS10270	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
XDD1_RS10275	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XDD1_RS10280	COG3099	Belongs to the UPF0263 family
XDD1_RS10290	COG0444	Belongs to the ABC transporter superfamily
XDD1_RS10295	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
XDD1_RS10315	COG1454	alcohol dehydrogenase
XDD1_RS10315	COG1012	belongs to the aldehyde dehydrogenase family
XDD1_RS10320	COG1435	thymidine kinase activity
XDD1_RS10340	COG1210	Utp--glucose-1-phosphate uridylyltransferase
XDD1_RS10345	COG3012	SEC-C Motif Domain Protein
XDD1_RS10350	COG0788	formyltetrahydrofolate deformylase activity
XDD1_RS10365	COG0708	Exodeoxyribonuclease III
XDD1_RS10370	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
XDD1_RS10375	COG0709	Synthesizes selenophosphate from selenide and ATP
XDD1_RS10380	COG0778	Nitroreductase
XDD1_RS10385	COG0616	signal peptide processing
XDD1_RS10390	COG0252	asparaginase activity
XDD1_RS10395	COG3139	Protein of unknown function (DUF1315)
XDD1_RS10415	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
XDD1_RS10420	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XDD1_RS10425	COG2186	Transcriptional regulator
XDD1_RS10430	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
XDD1_RS10435	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
XDD1_RS10440	COG2814	Major facilitator Superfamily
XDD1_RS10465	COG0531	amino acid
XDD1_RS10470	COG1982	Orn Lys Arg decarboxylase major
XDD1_RS10510	COG0076	glutamate decarboxylase activity
XDD1_RS10530	COG0076	glutamate decarboxylase activity
XDD1_RS10555	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
XDD1_RS10565	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
XDD1_RS10565	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
XDD1_RS10565	COG0506	proline dehydrogenase activity
XDD1_RS10575	COG1191	sigma factor activity
XDD1_RS10610	COG3335	DDE superfamily endonuclease
XDD1_RS10620	COG3077	Addiction module antitoxin, RelB DinJ family
XDD1_RS10625	COG1677	Flagellar hook-basal body complex protein FliE
XDD1_RS10630	COG1766	The M ring may be actively involved in energy transduction
XDD1_RS10635	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
XDD1_RS10640	COG1317	bacterial-type flagellum organization
XDD1_RS10645	COG1157	protein secretion by the type III secretion system
XDD1_RS10660	COG1580	Controls the rotational direction of flagella during chemotaxis
XDD1_RS10695	COG1028	Short-chain dehydrogenase reductase Sdr
XDD1_RS10715	COG3311	Transcriptional regulator
XDD1_RS10720	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
XDD1_RS10735	COG1706	bacterial-type flagellum-dependent cell motility
XDD1_RS10740	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
XDD1_RS10765	COG1558	bacterial-type flagellum-dependent cell motility
XDD1_RS10770	COG1815	bacterial-type flagellum-dependent cell motility
XDD1_RS10790	COG3335	DDE superfamily endonuclease
XDD1_RS10795	COG3539	Fimbrial protein
XDD1_RS10805	COG3121	Chaperone
XDD1_RS10835	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
XDD1_RS10840	COG1115	amino acid carrier protein
XDD1_RS10890	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
XDD1_RS10895	COG0745	RESPONSE REGULATOR receiver
XDD1_RS10900	COG2201	protein-glutamate methylesterase activity
XDD1_RS10905	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
XDD1_RS10910	COG0840	transmembrane signaling receptor activity
XDD1_RS10915	COG0840	transmembrane signaling receptor activity
XDD1_RS10920	COG0835	chemotaxis
XDD1_RS10925	COG0643	Histidine kinase
XDD1_RS10925	COG2198	Histidine kinase
XDD1_RS10930	COG1360	Flagellar Motor Protein
XDD1_RS10955	COG1285	pathogenesis
XDD1_RS10990	COG0418	dihydroorotase activity
XDD1_RS11005	COG1054	Belongs to the UPF0176 family
XDD1_RS11020	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
XDD1_RS11025	COG0518	GMP synthase (glutamine-hydrolyzing) activity
XDD1_RS11025	COG0519	Catalyzes the synthesis of GMP from XMP
XDD1_RS11030	COG0517	IMP dehydrogenase activity
XDD1_RS11030	COG0516	GMP reductase activity
XDD1_RS11035	COG1570	exodeoxyribonuclease VII activity
XDD1_RS11060	COG1629	transport
XDD1_RS11060	COG4206	TonB-dependent receptor
XDD1_RS11065	COG1770	oligopeptidase
XDD1_RS11080	COG0281	malic enzyme
XDD1_RS11080	COG0280	phosphate acetyltransferase
XDD1_RS11095	COG2197	response regulator
XDD1_RS11100	COG1393	Belongs to the ArsC family
XDD1_RS11105	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
XDD1_RS11110	COG1876	peptidase activity
XDD1_RS11120	COG1444	tRNA N-acetyltransferase activity
XDD1_RS11125	COG2707	UPF0756 membrane protein
XDD1_RS11130	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
XDD1_RS11135	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
XDD1_RS11140	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
XDD1_RS11145	COG2716	regulation of RNA biosynthetic process
XDD1_RS11160	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
XDD1_RS11165	COG0628	permease
XDD1_RS11170	COG4783	chaperone-mediated protein folding
XDD1_RS11175	COG1393	Belongs to the ArsC family
XDD1_RS11180	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
XDD1_RS11190	COG2233	PERMEase
XDD1_RS11195	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
XDD1_RS11200	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
XDD1_RS11205	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
XDD1_RS11210	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
XDD1_RS11215	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
XDD1_RS11220	COG0248	Ppx GppA phosphatase
XDD1_RS11225	COG2239	Acts as a magnesium transporter
XDD1_RS11245	COG1028	Short-chain dehydrogenase reductase Sdr
XDD1_RS11270	COG3220	belongs to the UPF0276 family
XDD1_RS11300	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XDD1_RS11305	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XDD1_RS11310	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XDD1_RS11315	COG2205	protein histidine kinase activity
XDD1_RS11320	COG0745	RESPONSE REGULATOR receiver
XDD1_RS11325	COG2814	Major facilitator Superfamily
XDD1_RS11330	COG3422	double-strand break repair
XDD1_RS11335	COG0826	peptidase U32
XDD1_RS11340	COG1830	Aldolase
XDD1_RS11345	COG0351	phosphomethylpyrimidine kinase
XDD1_RS11365	COG3023	N-Acetylmuramoyl-L-alanine amidase
XDD1_RS11370	COG1115	amino acid carrier protein
XDD1_RS11390	COG0538	isocitrate dehydrogenase activity
XDD1_RS11395	COG1187	pseudouridine synthase activity
XDD1_RS11405	COG0482	sulfurtransferase activity
XDD1_RS11410	COG2915	High frequency lysogenization protein hflD homolog
XDD1_RS11415	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
XDD1_RS11420	COG3335	DDE superfamily endonuclease
XDD1_RS11425	COG0745	RESPONSE REGULATOR receiver
XDD1_RS11435	COG2850	peptidyl-arginine hydroxylation
XDD1_RS11445	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
XDD1_RS11450	COG4591	ABC-type transport system involved in lipoprotein release permease component
XDD1_RS11455	COG1136	(ABC) transporter
XDD1_RS11460	COG4591	ABC-type transport system involved in lipoprotein release permease component
XDD1_RS11465	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
XDD1_RS11475	COG1252	NADH dehydrogenase
XDD1_RS11480	COG1472	Belongs to the glycosyl hydrolase 3 family
XDD1_RS11490	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
XDD1_RS11495	COG0537	adenosine 5'-monophosphoramidase activity
XDD1_RS11500	COG0084	hydrolase, TatD family'
XDD1_RS11505	COG0470	DNA polymerase III
XDD1_RS11510	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
XDD1_RS11515	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
XDD1_RS11520	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
XDD1_RS11525	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
XDD1_RS11530	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
XDD1_RS11540	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
XDD1_RS11545	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
XDD1_RS11550	COG0416	fatty acid biosynthetic process
XDD1_RS11555	COG0333	Belongs to the bacterial ribosomal protein bL32 family
XDD1_RS11560	COG1399	metal-binding, possibly nucleic acid-binding protein
XDD1_RS11565	COG0424	maF-like protein
XDD1_RS11570	COG0564	pseudouridine synthase activity
XDD1_RS11575	COG1530	ribonuclease E activity
XDD1_RS11580	COG0702	epimerase
XDD1_RS11585	COG2926	Belongs to the UPF0265 family
XDD1_RS11590	COG2925	Exonuclease
XDD1_RS11595	COG0277	FAD linked oxidase domain protein
XDD1_RS11600	COG0531	amino acid
XDD1_RS11605	COG4771	TonB-dependent receptor
XDD1_RS11610	COG3842	ATPase activity
XDD1_RS11615	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
XDD1_RS11625	COG0833	amino acid
XDD1_RS11630	COG0583	DNA-binding transcription factor activity
XDD1_RS11635	COG2855	membrane
XDD1_RS11640	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
XDD1_RS11645	COG1105	Belongs to the carbohydrate kinase PfkB family
XDD1_RS11650	COG2816	NAD+ diphosphatase activity
XDD1_RS11660	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
XDD1_RS11675	COG0671	phosphoesterase, PA-phosphatase related
XDD1_RS11680	COG0791	NLP P60 protein
XDD1_RS11690	COG2814	Major facilitator Superfamily
XDD1_RS11695	COG1187	pseudouridine synthase activity
XDD1_RS11700	COG1061	Type III restriction enzyme res subunit
XDD1_RS11705	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
XDD1_RS11710	COG3081	Nucleoid-associated protein
XDD1_RS11715	COG3082	Protein of unknown function (DUF1414)
XDD1_RS11730	COG3335	DDE superfamily endonuclease
XDD1_RS11750	COG3397	chitin binding
XDD1_RS11755	COG0346	lactoylglutathione lyase activity
XDD1_RS11770	COG3023	N-Acetylmuramoyl-L-alanine amidase
XDD1_RS11775	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
XDD1_RS11785	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
XDD1_RS11790	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
XDD1_RS11800	COG2205	protein histidine kinase activity
XDD1_RS11800	COG0784	Response regulator, receiver
XDD1_RS11805	COG2197	response regulator
XDD1_RS11810	COG2198	Histidine kinase
XDD1_RS11810	COG0642	Histidine kinase
XDD1_RS11825	COG0814	amino acid
XDD1_RS11840	COG1441	menaquinone biosynthetic process
XDD1_RS11845	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
XDD1_RS11850	COG0596	Alpha beta hydrolase
XDD1_RS11855	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
XDD1_RS11860	COG1169	isochorismate synthase
XDD1_RS11865	COG0457	Tetratricopeptide repeat
XDD1_RS11870	COG1649	PFAM Uncharacterised BCR, COG1649
XDD1_RS11870	COG0726	polysaccharide deacetylase
XDD1_RS11875	COG1215	transferase activity, transferring glycosyl groups
XDD1_RS11890	COG2199	diguanylate cyclase activity
XDD1_RS11895	COG2885	chlorophyll binding
XDD1_RS11900	COG2200	EAL domain
XDD1_RS11910	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
XDD1_RS11915	COG1007	ATP synthesis coupled electron transport
XDD1_RS11920	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XDD1_RS11925	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
XDD1_RS11930	COG0713	ATP synthesis coupled electron transport
XDD1_RS11935	COG0839	Belongs to the complex I subunit 6 family
XDD1_RS11940	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XDD1_RS11950	COG1034	ATP synthesis coupled electron transport
XDD1_RS11965	COG0649	NAD binding
XDD1_RS11965	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XDD1_RS11970	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XDD1_RS11975	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XDD1_RS11980	COG0583	DNA-binding transcription factor activity
XDD1_RS11985	COG0436	Aminotransferase
XDD1_RS11990	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
XDD1_RS11995	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
XDD1_RS12000	COG0490	domain, Protein
XDD1_RS12000	COG0471	metal ion transport
XDD1_RS12005	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
XDD1_RS12015	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
XDD1_RS12020	COG0280	phosphate acetyltransferase
XDD1_RS12020	COG0857	belongs to the CobB CobQ family
XDD1_RS12030	COG3335	DDE superfamily endonuclease
XDD1_RS12045	COG1475	DNA binding
XDD1_RS12075	COG0582	viral genome integration into host DNA
XDD1_RS12090	COG2067	long-chain fatty acid transport protein
XDD1_RS12095	COG3691	Protein conserved in bacteria
XDD1_RS12100	COG0183	Belongs to the thiolase family
XDD1_RS12105	COG1024	Enoyl-CoA hydratase
XDD1_RS12105	COG1250	3-hydroxyacyl-CoA dehydrogenase
XDD1_RS12110	COG2062	phosphohistidine phosphatase, SixA
XDD1_RS12115	COG2840	Smr protein MutS2
XDD1_RS12120	COG1228	amidohydrolase
XDD1_RS12125	COG0010	Belongs to the arginase family
XDD1_RS12135	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
XDD1_RS12140	COG2986	histidine ammonia-lyase
XDD1_RS12155	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
XDD1_RS12160	COG0730	response to heat
XDD1_RS12165	COG3101	peptidyl-lysine hydroxylation
XDD1_RS12185	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
XDD1_RS12185	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XDD1_RS12190	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
XDD1_RS12215	COG0642	Histidine kinase
XDD1_RS12225	COG2207	Transcriptional regulator
XDD1_RS12230	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
XDD1_RS12235	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
XDD1_RS12240	COG0101	tRNA pseudouridine synthase activity
XDD1_RS12245	COG0586	Pfam SNARE associated Golgi protein
XDD1_RS12250	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
XDD1_RS12255	COG0285	dihydrofolate synthase activity
XDD1_RS12260	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
XDD1_RS12265	COG1286	toxin biosynthetic process
XDD1_RS12270	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
XDD1_RS12275	COG0163	prenyltransferase activity
XDD1_RS12280	COG1090	epimerase
XDD1_RS12285	COG0625	glutathione transferase activity
XDD1_RS12290	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
XDD1_RS12325	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
XDD1_RS12330	COG3138	arginine N-succinyltransferase
XDD1_RS12335	COG1012	belongs to the aldehyde dehydrogenase family
XDD1_RS12340	COG3724	N-succinylarginine dihydrolase activity
XDD1_RS12345	COG2988	succinylglutamate desuccinylase activity
XDD1_RS12350	COG1113	amino acid transport
XDD1_RS12425	COG0859	PFAM glycosyl transferase family 9
XDD1_RS12475	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
XDD1_RS12490	COG1028	Short-chain dehydrogenase reductase Sdr
XDD1_RS12495	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
XDD1_RS12500	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
XDD1_RS12505	COG3115	cell septum assembly
XDD1_RS12520	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
XDD1_RS12530	COG2190	(PTS) system
XDD1_RS12535	COG1250	3-hydroxyacyl-CoA dehydrogenase
XDD1_RS12595	COG1960	acyl-CoA dehydrogenase activity
XDD1_RS12600	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
XDD1_RS12605	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
XDD1_RS12625	COG3842	ATPase activity
XDD1_RS12630	COG0584	glycerophosphoryl diester phosphodiesterase
XDD1_RS12650	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
XDD1_RS12655	COG4208	sulfate ABC transporter
XDD1_RS12660	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
XDD1_RS12675	COG0456	acetyltransferase
XDD1_RS12750	COG1802	Transcriptional regulator
XDD1_RS12750	COG4626	Terminase
XDD1_RS12760	COG3423	Transcriptional regulator
XDD1_RS12765	COG0408	coproporphyrinogen oxidase activity
XDD1_RS12800	COG1160	GTP binding
XDD1_RS12805	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XDD1_RS12810	COG2976	Protein conserved in bacteria
XDD1_RS12815	COG0124	histidyl-tRNA synthetase
XDD1_RS12820	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
XDD1_RS12835	COG0820	rRNA (adenine-C2-)-methyltransferase activity
XDD1_RS12840	COG0105	UTP biosynthetic process
XDD1_RS12845	COG3655	Transcriptional regulator
XDD1_RS12855	COG4953	penicillin-binding protein 1C
XDD1_RS12860	COG2373	Large extracellular alpha-helical protein
XDD1_RS12870	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
XDD1_RS12875	COG2975	iron-sulfur cluster assembly
XDD1_RS12880	COG0633	Ferredoxin
XDD1_RS12885	COG0443	Heat shock 70 kDa protein
XDD1_RS12890	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
XDD1_RS12895	COG0316	Belongs to the HesB IscA family
XDD1_RS12900	COG0822	iron-sulfur transferase activity
XDD1_RS12905	COG1104	cysteine desulfurase activity
XDD1_RS12910	COG1959	2 iron, 2 sulfur cluster binding
XDD1_RS12915	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
XDD1_RS12925	COG2814	Major facilitator Superfamily
XDD1_RS12930	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
XDD1_RS12935	COG1017	nitric oxide dioxygenase activity
XDD1_RS12935	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
XDD1_RS12940	COG0347	Belongs to the P(II) protein family
XDD1_RS12945	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
XDD1_RS12945	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
XDD1_RS12950	COG2204	response regulator
XDD1_RS12955	COG3170	Tfp pilus assembly protein FimV
XDD1_RS12960	COG2205	protein histidine kinase activity
XDD1_RS12965	COG0047	phosphoribosylformylglycinamidine synthase activity
XDD1_RS12965	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
XDD1_RS12970	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
XDD1_RS12980	COG1418	mRNA catabolic process
XDD1_RS12985	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
XDD1_RS12995	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
XDD1_RS13000	COG0736	holo-[acyl-carrier-protein] synthase activity
XDD1_RS13005	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
XDD1_RS13010	COG1381	Involved in DNA repair and RecF pathway recombination
XDD1_RS13015	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
XDD1_RS13020	COG0571	ribonuclease III activity
XDD1_RS13025	COG0681	Belongs to the peptidase S26 family
XDD1_RS13030	COG0481	GTPase activity
XDD1_RS13035	COG3086	response to oxidative stress
XDD1_RS13050	COG1595	DNA-templated transcription, initiation
XDD1_RS13055	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
XDD1_RS13060	COG0513	Belongs to the DEAD box helicase family
XDD1_RS13070	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
XDD1_RS13075	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
XDD1_RS13080	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
XDD1_RS13085	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
XDD1_RS13090	COG0497	DNA recombination
XDD1_RS13095	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XDD1_RS13100	COG2914	Belongs to the UPF0125 (RnfH) family
XDD1_RS13105	COG2867	negative regulation of translational initiation
XDD1_RS13110	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
XDD1_RS13230	COG4695	Portal protein
XDD1_RS13280	COG4974	Belongs to the 'phage' integrase family
XDD1_RS13290	COG3335	DDE superfamily endonuclease
XDD1_RS13355	COG3038	cytochrome b561
XDD1_RS13360	COG2353	YceI-like domain
XDD1_RS13380	COG1309	transcriptional regulator
XDD1_RS13385	COG2814	Major facilitator Superfamily
XDD1_RS13395	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
XDD1_RS13405	COG2841	Protein conserved in bacteria
XDD1_RS13545	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
XDD1_RS13550	COG1028	Short-chain dehydrogenase reductase Sdr
XDD1_RS13555	COG0318	PFAM AMP-dependent synthetase and ligase
XDD1_RS13570	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
XDD1_RS13575	COG0346	lactoylglutathione lyase activity
XDD1_RS13590	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
XDD1_RS13590	COG1522	sequence-specific DNA binding
XDD1_RS13625	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
XDD1_RS13630	COG0732	type I restriction modification DNA specificity domain
XDD1_RS13645	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
XDD1_RS13650	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
XDD1_RS13655	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
XDD1_RS13660	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
XDD1_RS13665	COG4974	Belongs to the 'phage' integrase family
XDD1_RS13670	COG0716	FMN binding
XDD1_RS13675	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
XDD1_RS13680	COG0354	folic acid binding
XDD1_RS13690	COG3135	benzoate transporter
XDD1_RS13700	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
XDD1_RS13710	COG3335	DDE superfamily endonuclease
XDD1_RS13715	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
XDD1_RS13720	COG2814	Major facilitator Superfamily
XDD1_RS13730	COG2192	nodulation
XDD1_RS13740	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
XDD1_RS13740	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
XDD1_RS13745	COG0509	glycine decarboxylation via glycine cleavage system
XDD1_RS13750	COG0404	The glycine cleavage system catalyzes the degradation of glycine
XDD1_RS13755	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XDD1_RS13760	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XDD1_RS13765	COG0006	proline dipeptidase activity
XDD1_RS13770	COG3079	Belongs to the UPF0149 family
XDD1_RS13780	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
XDD1_RS13785	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
XDD1_RS13790	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
XDD1_RS13795	COG0583	DNA-binding transcription factor activity
XDD1_RS13805	COG1279	arginine transmembrane transporter activity
XDD1_RS13810	COG0668	transmembrane transport
XDD1_RS13815	COG3112	Uncharacterised protein family (UPF0231)
XDD1_RS13835	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
XDD1_RS13840	COG0508	dehydrogenase complex catalyzes the overall conversion of
XDD1_RS13845	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
XDD1_RS13850	COG2186	Transcriptional regulator
XDD1_RS13860	COG3725	Membrane protein required for beta-lactamase induction
XDD1_RS13865	COG3023	N-Acetylmuramoyl-L-alanine amidase
XDD1_RS13870	COG4969	Belongs to the N-Me-Phe pilin family
XDD1_RS13875	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
XDD1_RS13885	COG0237	dephospho-CoA kinase activity
XDD1_RS13890	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
XDD1_RS13895	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
XDD1_RS13900	COG0494	nUDIX hydrolase
XDD1_RS13905	COG0653	protein targeting
XDD1_RS13920	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
XDD1_RS13930	COG0849	cell division
XDD1_RS13935	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
XDD1_RS13940	COG1181	Belongs to the D-alanine--D-alanine ligase family
XDD1_RS13945	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
XDD1_RS13950	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
XDD1_RS13955	COG0772	Belongs to the SEDS family
XDD1_RS13960	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
XDD1_RS13965	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
XDD1_RS13970	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
XDD1_RS13975	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
XDD1_RS13980	COG0768	penicillin binding
XDD1_RS13985	COG3116	cell division
XDD1_RS13990	COG0275	rRNA processing
XDD1_RS13995	COG2001	Belongs to the MraZ family
XDD1_RS14010	COG0028	Belongs to the TPP enzyme family
XDD1_RS14015	COG1022	Amp-dependent synthetase and ligase
XDD1_RS14030	COG0473	3-isopropylmalate dehydrogenase activity
XDD1_RS14035	COG3066	DNA modification
XDD1_RS14045	COG0242	peptide deformylase activity
XDD1_RS14050	COG0626	cystathionine gamma-synthase activity
XDD1_RS14090	COG3842	ATPase activity
XDD1_RS14095	COG0534	Mate efflux family protein
XDD1_RS14115	COG0814	amino acid
XDD1_RS14120	COG0582	viral genome integration into host DNA
XDD1_RS14125	COG0523	cobalamin synthesis protein
XDD1_RS14130	COG2879	small protein
XDD1_RS14135	COG1966	Carbon starvation protein
XDD1_RS14140	COG2194	sulfuric ester hydrolase activity
XDD1_RS14155	COG1840	ABC-type Fe3 transport system, periplasmic component
XDD1_RS14165	COG2271	Major facilitator Superfamily
XDD1_RS14185	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
XDD1_RS14190	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
XDD1_RS14210	COG3335	DDE superfamily endonuclease
XDD1_RS14270	COG1802	Transcriptional regulator
XDD1_RS14270	COG4626	Terminase
XDD1_RS14285	COG3423	Transcriptional regulator
XDD1_RS14305	COG0288	reversible hydration of carbon dioxide
XDD1_RS14310	COG1131	(ABC) transporter
XDD1_RS14315	COG0842	Transport permease protein
XDD1_RS14320	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
XDD1_RS14325	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
XDD1_RS14330	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
XDD1_RS14340	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
XDD1_RS14350	COG1489	DNA binding
XDD1_RS14355	COG1643	Atp-dependent helicase
XDD1_RS14360	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
XDD1_RS14390	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
XDD1_RS14395	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
XDD1_RS14400	COG0316	Belongs to the HesB IscA family
XDD1_RS14405	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
XDD1_RS14410	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
XDD1_RS14415	COG0232	Belongs to the dGTPase family. Type 2 subfamily
XDD1_RS14420	COG3850	Histidine kinase
XDD1_RS14420	COG3437	response regulator, receiver
XDD1_RS14420	COG4999	Histidine kinase
XDD1_RS14420	COG2205	protein histidine kinase activity
XDD1_RS14425	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
XDD1_RS14430	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
XDD1_RS14435	COG3956	TIGRFAM MazG family protein
XDD1_RS14440	COG0504	CTP synthase activity
XDD1_RS14445	COG0148	phosphopyruvate hydratase activity
XDD1_RS14460	COG0471	metal ion transport
XDD1_RS14470	COG1301	dicarboxylic acid transport
XDD1_RS14485	COG3091	SprT-like family
XDD1_RS14490	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
XDD1_RS14495	COG1166	arginine decarboxylase activity
XDD1_RS14500	COG0010	Belongs to the arginase family
XDD1_RS14525	COG1085	galactose-1-phosphate uridylyltransferase
XDD1_RS14530	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
XDD1_RS14560	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
XDD1_RS14575	COG4942	peptidase
XDD1_RS14575	COG1388	LysM domain
XDD1_RS14580	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
XDD1_RS14585	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
XDD1_RS14590	COG0585	pseudouridine synthase activity
XDD1_RS14595	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
XDD1_RS14600	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
XDD1_RS14605	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
XDD1_RS14615	COG2895	sulfate adenylyltransferase (ATP) activity
XDD1_RS14620	COG0175	sulfate reduction
XDD1_RS14625	COG1648	precorrin-2 dehydrogenase activity
XDD1_RS14625	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
XDD1_RS14630	COG0175	sulfate reduction
XDD1_RS14635	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
XDD1_RS14640	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
XDD1_RS14645	COG0720	synthase
XDD1_RS14650	COG0602	queuosine metabolic process
XDD1_RS14660	COG3021	interspecies interaction between organisms
XDD1_RS14695	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
XDD1_RS14705	COG1739	Uncharacterized protein family UPF0029
XDD1_RS14710	COG0006	proline dipeptidase activity
XDD1_RS14715	COG1024	Enoyl-CoA hydratase
XDD1_RS14715	COG1250	3-hydroxyacyl-CoA dehydrogenase
XDD1_RS14720	COG0183	Belongs to the thiolase family
XDD1_RS14730	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
XDD1_RS14745	COG0805	protein transport
XDD1_RS14750	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
XDD1_RS14755	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
XDD1_RS14760	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
XDD1_RS14765	COG3165	ubiquinone biosynthetic process from chorismate
XDD1_RS14770	COG2226	methyltransferase
XDD1_RS14775	COG1322	Protein conserved in bacteria
XDD1_RS14780	COG0586	Pfam SNARE associated Golgi protein
XDD1_RS14795	COG2610	gluconate transmembrane transporter activity
XDD1_RS14800	COG2610	gluconate transmembrane transporter activity
XDD1_RS14805	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
XDD1_RS14810	COG1349	DNA-binding transcription factor activity
XDD1_RS14815	COG3622	Belongs to the hyi family
XDD1_RS14820	COG3395	kinase activity
XDD1_RS14835	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
XDD1_RS14840	COG0583	DNA-binding transcription factor activity
XDD1_RS14845	COG0025	NhaP-type Na H and K H
XDD1_RS14850	COG2252	PERMEase
XDD1_RS14895	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
XDD1_RS14910	COG1448	Aminotransferase
XDD1_RS14925	COG3423	Transcriptional regulator
XDD1_RS15015	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
XDD1_RS15025	COG0735	belongs to the Fur family
XDD1_RS15035	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
XDD1_RS15040	COG2937	Belongs to the GPAT DAPAT family
XDD1_RS15045	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
XDD1_RS15050	COG3161	chorismate lyase activity
XDD1_RS15055	COG0166	Belongs to the GPI family
XDD1_RS15060	COG0527	aspartate kinase activity
XDD1_RS15070	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
XDD1_RS15080	COG0800	Aldolase
XDD1_RS15085	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
XDD1_RS15090	COG2224	Isocitrate lyase
XDD1_RS15095	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
XDD1_RS15100	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
XDD1_RS15130	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
XDD1_RS15135	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
XDD1_RS15145	COG1464	Belongs to the NlpA lipoprotein family
XDD1_RS15155	COG1720	tRNA m6t6A37 methyltransferase activity
XDD1_RS15160	COG0442	prolyl-tRNA aminoacylation
XDD1_RS15165	COG3015	lipoprotein NlpE involved in copper resistance
XDD1_RS15170	COG4568	rho-dependent transcription termination
XDD1_RS15180	COG0037	tRNA processing
XDD1_RS15190	COG0825	malonyl-CoA metabolic process
XDD1_RS15200	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
XDD1_RS15205	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XDD1_RS15210	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XDD1_RS15215	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
XDD1_RS15220	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XDD1_RS15230	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XDD1_RS15235	COG0750	zinc metalloprotease
XDD1_RS15240	COG0575	Belongs to the CDS family
XDD1_RS15245	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
XDD1_RS15250	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
XDD1_RS15255	COG0233	cytoplasmic translational termination
XDD1_RS15260	COG0528	UMP kinase activity
XDD1_RS15265	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
XDD1_RS15270	COG0052	Belongs to the universal ribosomal protein uS2 family
XDD1_RS15280	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
XDD1_RS15305	COG0564	pseudouridine synthase activity
XDD1_RS15310	COG3098	single-species biofilm formation
XDD1_RS15335	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
XDD1_RS15335	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
XDD1_RS15345	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
XDD1_RS15390	COG2890	protein-(glutamine-N5) methyltransferase activity
XDD1_RS15395	COG0156	8-amino-7-oxononanoate synthase activity
XDD1_RS15410	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
XDD1_RS15410	COG0512	Glutamine amidotransferase of anthranilate synthase
XDD1_RS15420	COG0477	Major facilitator Superfamily
XDD1_RS15425	COG1028	Short-chain dehydrogenase reductase Sdr
XDD1_RS15430	COG1028	Short-chain dehydrogenase reductase Sdr
XDD1_RS15440	COG2363	Small membrane protein
XDD1_RS15445	COG0583	DNA-binding transcription factor activity
XDD1_RS15450	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
XDD1_RS15475	COG2166	iron-sulfur cluster assembly
XDD1_RS15480	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
XDD1_RS15485	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
XDD1_RS15500	COG0860	N-Acetylmuramoyl-L-alanine amidase
XDD1_RS15505	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
XDD1_RS15505	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
XDD1_RS15510	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
XDD1_RS15515	COG1074	ATP-dependent DNA helicase activity
XDD1_RS15525	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
XDD1_RS15545	COG2165	general secretion pathway protein
XDD1_RS15555	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
XDD1_RS15560	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
XDD1_RS15565	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
XDD1_RS15570	COG0494	nUDIX hydrolase
XDD1_RS15575	COG4143	(ABC) transporter
XDD1_RS15580	COG1178	ABC-type Fe3 transport system permease component
XDD1_RS15585	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
XDD1_RS15605	COG0417	DNA replication proofreading
XDD1_RS15610	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
XDD1_RS15615	COG0564	pseudouridine synthase activity
XDD1_RS15620	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
XDD1_RS15625	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
XDD1_RS15630	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
XDD1_RS15635	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
XDD1_RS15640	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
XDD1_RS15645	COG2967	ApaG domain
XDD1_RS15650	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
XDD1_RS15660	COG2132	Multicopper oxidase
XDD1_RS15665	COG0204	Acyl-transferase
XDD1_RS15670	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
XDD1_RS15680	COG3150	esterase
XDD1_RS15685	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
XDD1_RS15690	COG0494	nUDIX hydrolase
XDD1_RS15695	COG1538	Outer membrane efflux protein
XDD1_RS15700	COG5463	Belongs to the UPF0441 family
XDD1_RS15705	COG0754	glutathionylspermidine amidase activity
XDD1_RS15710	COG3384	dioxygenase
XDD1_RS15715	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
XDD1_RS15725	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
XDD1_RS15725	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
XDD1_RS15730	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
XDD1_RS15735	COG3025	triphosphatase activity
XDD1_RS15740	COG4991	sh3 domain protein
XDD1_RS15745	COG0617	tRNA 3'-terminal CCA addition
XDD1_RS15750	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
XDD1_RS15755	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
XDD1_RS15760	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
XDD1_RS15770	COG0828	Belongs to the bacterial ribosomal protein bS21 family
XDD1_RS15775	COG0358	DNA primase activity
XDD1_RS15795	COG1598	PFAM Uncharacterised protein family UPF0150
XDD1_RS15800	COG1724	mRNA binding
XDD1_RS15920	COG4695	Portal protein
XDD1_RS15975	COG4974	Belongs to the 'phage' integrase family
XDD1_RS16000	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
XDD1_RS16005	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
XDD1_RS16020	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
XDD1_RS16050	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
XDD1_RS16060	COG1028	Short-chain dehydrogenase reductase Sdr
XDD1_RS16080	COG2990	Protein conserved in bacteria
XDD1_RS16090	COG1902	pentaerythritol trinitrate reductase activity
XDD1_RS16090	COG0446	pyridine nucleotide-disulphide oxidoreductase
XDD1_RS16095	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
XDD1_RS16100	COG0586	Pfam SNARE associated Golgi protein
XDD1_RS16105	COG4575	ribosome binding
XDD1_RS16110	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
XDD1_RS16120	COG2259	Doxx family
XDD1_RS16125	COG0583	DNA-binding transcription factor activity
XDD1_RS16130	COG1741	Belongs to the pirin family
XDD1_RS16135	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
XDD1_RS16145	COG0792	nuclease activity
XDD1_RS16150	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
XDD1_RS16155	COG2823	Periplasmic or secreted lipoprotein
XDD1_RS16180	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
XDD1_RS16185	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
XDD1_RS16190	COG0784	Response regulator, receiver
XDD1_RS16190	COG2198	Histidine kinase
XDD1_RS16190	COG5002	protein histidine kinase activity
XDD1_RS16195	COG0069	glutamate synthase activity
XDD1_RS16195	COG0067	glutamate synthase
XDD1_RS16195	COG0070	glutamate synthase
XDD1_RS16200	COG0493	'glutamate synthase
XDD1_RS16210	COG2969	positive regulation of protein catabolic process
XDD1_RS16215	COG0625	glutathione transferase activity
XDD1_RS16220	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
XDD1_RS16225	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
XDD1_RS16230	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
XDD1_RS16235	COG3105	Protein conserved in bacteria
XDD1_RS16240	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
XDD1_RS16245	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
XDD1_RS16250	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
XDD1_RS16255	COG5007	Belongs to the BolA IbaG family
XDD1_RS16265	COG2854	intermembrane phospholipid transfer
XDD1_RS16270	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
XDD1_RS16275	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
XDD1_RS16280	COG1127	ABC transporter
XDD1_RS16285	COG0530	calcium, potassium:sodium antiporter activity
XDD1_RS16290	COG0517	IMP dehydrogenase activity
XDD1_RS16290	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
XDD1_RS16295	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
XDD1_RS16300	COG3117	lipopolysaccharide transmembrane transporter activity
XDD1_RS16305	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
XDD1_RS16310	COG1137	ATPase activity
XDD1_RS16315	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
XDD1_RS16330	COG1660	Displays ATPase and GTPase activities
XDD1_RS16335	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
XDD1_RS16345	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
XDD1_RS16360	COG0312	modulator of DNA gyrase
XDD1_RS16365	COG3028	Belongs to the UPF0307 family
XDD1_RS16370	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
XDD1_RS16380	COG0789	Transcriptional regulator
XDD1_RS16395	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XDD1_RS16400	COG0312	modulator of DNA gyrase
XDD1_RS16405	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
XDD1_RS16410	COG3164	Protein of unknown function
XDD1_RS16420	COG0424	maF-like protein
XDD1_RS16425	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
XDD1_RS16430	COG1792	Involved in formation and maintenance of cell shape
XDD1_RS16435	COG1077	Cell shape determining protein MreB Mrl
XDD1_RS16440	COG0604	alcohol dehydrogenase
XDD1_RS16445	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
XDD1_RS16450	COG0511	ligase activity, forming carbon-carbon bonds
XDD1_RS16455	COG0439	Biotin carboxylase
XDD1_RS16460	COG3924	membrane
XDD1_RS16465	COG4145	pantothenate transmembrane transporter activity
XDD1_RS16470	COG2264	protein methyltransferase activity
XDD1_RS16475	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
XDD1_RS16480	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
XDD1_RS16515	COG1396	sequence-specific DNA binding
XDD1_RS16520	COG1929	Belongs to the glycerate kinase type-1 family
XDD1_RS16530	COG2177	Part of the ABC transporter FtsEX involved in
XDD1_RS16535	COG2884	Cell division ATP-binding protein ftsE
XDD1_RS16540	COG0552	protein localization to endoplasmic reticulum
XDD1_RS16540	COG0552	protein localization to endoplasmic reticulum
XDD1_RS16545	COG0742	ribosomal rna small subunit methyltransferase
XDD1_RS16550	COG3776	membrane
XDD1_RS16555	COG2217	Heavy metal translocating P-type atpase
XDD1_RS16560	COG0425	Belongs to the sulfur carrier protein TusA family
XDD1_RS16565	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
XDD1_RS16575	COG0318	PFAM AMP-dependent synthetase and ligase
XDD1_RS16575	COG1028	Short-chain dehydrogenase reductase Sdr
XDD1_RS16575	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
XDD1_RS16575	COG3321	synthase
XDD1_RS16575	COG0300	oxidoreductase activity
XDD1_RS16580	COG2271	Major facilitator Superfamily
XDD1_RS16585	COG0584	glycerophosphoryl diester phosphodiesterase
XDD1_RS16590	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
XDD1_RS16595	COG1053	succinate dehydrogenase
XDD1_RS16600	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
XDD1_RS16605	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
XDD1_RS16610	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
XDD1_RS16625	COG4770	biotin carboxylase activity
XDD1_RS16635	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
XDD1_RS16640	COG1914	H( )-stimulated, divalent metal cation uptake system
XDD1_RS16670	COG0138	bifunctional purine biosynthesis protein purh
XDD1_RS16675	COG0151	Belongs to the GarS family
XDD1_RS16695	COG1515	deoxyribonuclease V activity
XDD1_RS16705	COG2816	NAD+ diphosphatase activity
XDD1_RS16710	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
XDD1_RS16715	COG0352	thiamine-phosphate diphosphorylase activity
XDD1_RS16720	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
XDD1_RS16730	COG2022	thiamine diphosphate biosynthetic process
XDD1_RS16740	COG1051	belongs to the nudix hydrolase family
XDD1_RS16745	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
XDD1_RS16760	COG2223	nitrite transmembrane transporter activity
XDD1_RS16765	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
XDD1_RS16775	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
XDD1_RS16780	COG2909	trisaccharide binding
XDD1_RS16785	COG0058	SHG alpha-glucan phosphorylase activity
XDD1_RS16790	COG1640	4-alpha-glucanotransferase
XDD1_RS16795	COG3833	ABC-type maltose transport systems, permease component
XDD1_RS16800	COG1175	transmembrane transport
XDD1_RS16805	COG2182	Extracellular solute-binding protein
XDD1_RS16810	COG3842	ATPase activity
XDD1_RS16815	COG4580	involved in the transport of maltose and maltodextrins
XDD1_RS16830	COG0726	polysaccharide deacetylase
XDD1_RS16835	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
XDD1_RS16840	COG0085	RNA polymerase activity
XDD1_RS16845	COG0222	ribosome binding
XDD1_RS16850	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
XDD1_RS16855	COG0081	regulation of translation
XDD1_RS16860	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
XDD1_RS16865	COG0250	Participates in transcription elongation, termination and antitermination
XDD1_RS16875	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
XDD1_RS16880	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
XDD1_RS16885	COG0049	tRNA binding
XDD1_RS16890	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
XDD1_RS16895	COG2168	tRNA wobble position uridine thiolation
XDD1_RS16900	COG2923	Belongs to the DsrF TusC family
XDD1_RS16905	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
XDD1_RS16910	COG2964	Protein conserved in bacteria
XDD1_RS16915	COG0545	Peptidyl-prolyl cis-trans isomerase
XDD1_RS16920	COG2900	Belongs to the SlyX family
XDD1_RS16925	COG1047	Peptidyl-prolyl cis-trans
XDD1_RS16930	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
XDD1_RS16935	COG0488	(ABC) transporter
XDD1_RS16940	COG0583	DNA-binding transcription factor activity
XDD1_RS16945	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
XDD1_RS16950	COG1263	PTS System
XDD1_RS16950	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
XDD1_RS16960	COG3089	Belongs to the UPF0270 family
XDD1_RS16965	COG3954	Phosphoribulokinase
XDD1_RS16970	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
XDD1_RS16975	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
XDD1_RS16985	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
XDD1_RS16990	COG0218	Necessary for normal cell division and for the maintenance of normal septation
XDD1_RS17000	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
XDD1_RS17005	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
XDD1_RS17010	COG3084	Protein conserved in bacteria
XDD1_RS17025	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
XDD1_RS17030	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
XDD1_RS17040	COG1070	Carbohydrate kinase
XDD1_RS17045	COG2390	Transcriptional regulator
XDD1_RS17060	COG1172	Belongs to the binding-protein-dependent transport system permease family
XDD1_RS17070	COG1830	Aldolase
XDD1_RS17075	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
XDD1_RS17080	COG0076	glutamate decarboxylase activity
XDD1_RS17085	COG1763	Mo-molybdopterin cofactor biosynthetic process
XDD1_RS17090	COG0746	molybdenum cofactor guanylyltransferase activity
XDD1_RS17130	COG3209	COG3209 Rhs family protein
XDD1_RS17170	COG3209	COG3209 Rhs family protein
XDD1_RS17185	COG3501	Rhs element vgr protein
XDD1_RS17280	COG3209	COG3209 Rhs family protein
XDD1_RS17295	COG3501	Rhs element vgr protein
XDD1_RS17335	COG3209	COG3209 Rhs family protein
XDD1_RS17335	COG4104	PAAR repeat-containing protein
XDD1_RS17345	COG3501	Rhs element vgr protein
XDD1_RS17440	COG1295	ribonuclease BN
XDD1_RS17445	COG1942	4-Oxalocrotonate Tautomerase
XDD1_RS17465	COG0612	Peptidase, M16
XDD1_RS17470	COG2199	diguanylate cyclase activity
XDD1_RS17470	COG2200	EAL domain
XDD1_RS17475	COG4608	Belongs to the ABC transporter superfamily
XDD1_RS17480	COG0444	Belongs to the ABC transporter superfamily
XDD1_RS17485	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
XDD1_RS17490	COG0601	transmembrane transport
XDD1_RS17495	COG0747	negative chemotaxis
XDD1_RS17530	COG0751	glycine-tRNA ligase activity
XDD1_RS17535	COG0752	glycyl-tRNA synthetase alpha subunit
XDD1_RS17540	COG2818	Glycosylase
XDD1_RS17555	COG3977	Valine--pyruvate aminotransferase
XDD1_RS17560	COG5645	(Lipo)protein
XDD1_RS17565	COG0823	Involved in the tonB-independent uptake of proteins
XDD1_RS17570	COG2860	membrane
XDD1_RS17575	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
XDD1_RS17580	COG0194	GDP metabolic process
XDD1_RS17590	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
XDD1_RS17595	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
XDD1_RS17605	COG0786	glutamate:sodium symporter activity
XDD1_RS17610	COG2233	PERMEase
XDD1_RS17620	COG0456	acetyltransferase
XDD1_RS17625	COG1490	D-aminoacyl-tRNA deacylase activity
XDD1_RS17640	COG1011	Hydrolase
XDD1_RS17650	COG1217	gtp-binding protein TYPA
XDD1_RS17715	COG2204	response regulator
XDD1_RS17720	COG2337	Toxic component of a toxin-antitoxin (TA) module
XDD1_RS17745	COG2252	PERMEase
XDD1_RS17770	COG3157	Type VI secretion system effector, Hcp
XDD1_RS17775	COG0765	amino acid transport
XDD1_RS17780	COG0765	amino acid transport
XDD1_RS17785	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
XDD1_RS17790	COG0704	Plays a role in the regulation of phosphate uptake
XDD1_RS17795	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
XDD1_RS17800	COG0581	inorganic phosphate transmembrane transporter activity
XDD1_RS17805	COG0573	inorganic phosphate transmembrane transporter activity
XDD1_RS17810	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
XDD1_RS17855	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
XDD1_RS17860	COG2183	response to ionizing radiation
XDD1_RS17865	COG1918	ferrous iron import across plasma membrane
XDD1_RS17880	COG0583	DNA-binding transcription factor activity
XDD1_RS17940	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
XDD1_RS17960	COG0596	Alpha beta hydrolase
XDD1_RS17965	COG1040	competence protein
XDD1_RS17970	COG0316	Belongs to the HesB IscA family
XDD1_RS17970	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
XDD1_RS17975	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
XDD1_RS17980	COG0705	Rhomboid family
XDD1_RS17985	COG1349	DNA-binding transcription factor activity
XDD1_RS17990	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
XDD1_RS18015	COG3335	DDE superfamily endonuclease
XDD1_RS18025	COG2188	Transcriptional regulator
XDD1_RS18035	COG3457	Alanine racemase
XDD1_RS18040	COG1735	metal-dependent hydrolase with the TIM-barrel fold
XDD1_RS18055	COG0626	cystathionine gamma-synthase activity
XDD1_RS18090	COG2030	dehydratase
XDD1_RS18090	COG1012	belongs to the aldehyde dehydrogenase family
XDD1_RS18095	COG3396	Phenylacetate-CoA oxygenase
XDD1_RS18100	COG3460	Phenylacetate-CoA oxygenase
XDD1_RS18105	COG3396	Phenylacetate-CoA oxygenase
XDD1_RS18110	COG2151	metal-sulfur cluster biosynthetic enzyme
XDD1_RS18115	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
XDD1_RS18120	COG1024	Enoyl-CoA hydratase
XDD1_RS18125	COG1024	Enoyl-CoA hydratase
XDD1_RS18130	COG1250	3-hydroxyacyl-CoA dehydrogenase
XDD1_RS18135	COG2050	protein possibly involved in aromatic compounds catabolism
XDD1_RS18140	COG0183	Belongs to the thiolase family
XDD1_RS18145	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
XDD1_RS18150	COG2814	Major facilitator Superfamily
XDD1_RS18195	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
XDD1_RS18205	COG2188	Transcriptional regulator
XDD1_RS18210	COG1368	sulfuric ester hydrolase activity
XDD1_RS18225	COG3276	selenocysteine insertion sequence binding
XDD1_RS18250	COG1921	L-seryl-tRNASec selenium transferase activity
XDD1_RS18255	COG3058	Necessary for formate dehydrogenase activity
XDD1_RS18265	COG2864	formate dehydrogenase
XDD1_RS18270	COG0437	4 iron, 4 sulfur cluster binding
XDD1_RS18275	COG3383	formate dehydrogenase (NAD+) activity
XDD1_RS18275	COG0243	molybdopterin cofactor binding
XDD1_RS18280	COG0243	molybdopterin cofactor binding
XDD1_RS18280	COG3383	formate dehydrogenase (NAD+) activity
XDD1_RS18285	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
XDD1_RS18325	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
XDD1_RS18330	COG0706	membrane insertase activity
XDD1_RS18335	COG0594	ribonuclease P activity
XDD1_RS18395	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
XDD1_RS18445	COG1121	(ABC) transporter
XDD1_RS18450	COG3842	ATPase activity
XDD1_RS18490	COG5301	cellulose 1,4-beta-cellobiosidase activity
XDD1_RS18520	COG3209	COG3209 Rhs family protein
XDD1_RS18540	COG1470	cell adhesion involved in biofilm formation
XDD1_RS18540	COG1388	LysM domain
XDD1_RS18550	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
XDD1_RS18550	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus