locus-tag	class	description
A9255_RS00075	COG5301	cellulose 1,4-beta-cellobiosidase activity
A9255_RS00135	COG2841	Protein conserved in bacteria
A9255_RS00155	COG2814	Major facilitator Superfamily
A9255_RS00185	COG2353	YceI-like domain
A9255_RS00190	COG3038	cytochrome b561
A9255_RS00205	COG2079	MmgE PrpD family protein
A9255_RS00240	COG1278	Cold shock
A9255_RS00260	COG5301	cellulose 1,4-beta-cellobiosidase activity
A9255_RS00380	COG3561	AntA/AntB antirepressor
A9255_RS00475	COG4381	Mu-like prophage protein gp46
A9255_RS00500	COG5301	cellulose 1,4-beta-cellobiosidase activity
A9255_RS00515	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
A9255_RS00520	COG2867	negative regulation of translational initiation
A9255_RS00525	COG2914	Belongs to the UPF0125 (RnfH) family
A9255_RS00530	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A9255_RS00535	COG0497	DNA recombination
A9255_RS00540	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A9255_RS00545	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A9255_RS00550	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
A9255_RS00560	COG0513	Belongs to the DEAD box helicase family
A9255_RS00565	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
A9255_RS00570	COG1595	DNA-templated transcription, initiation
A9255_RS00585	COG3086	response to oxidative stress
A9255_RS00590	COG0481	GTPase activity
A9255_RS00595	COG0681	Belongs to the peptidase S26 family
A9255_RS00600	COG0571	ribonuclease III activity
A9255_RS00605	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
A9255_RS00610	COG1381	Involved in DNA repair and RecF pathway recombination
A9255_RS00615	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
A9255_RS00620	COG0736	holo-[acyl-carrier-protein] synthase activity
A9255_RS00625	COG0583	DNA-binding transcription factor activity
A9255_RS00630	COG2814	Major facilitator Superfamily
A9255_RS00635	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
A9255_RS00815	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
A9255_RS00825	COG1418	mRNA catabolic process
A9255_RS00835	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
A9255_RS00840	COG0047	phosphoribosylformylglycinamidine synthase activity
A9255_RS00840	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A9255_RS00845	COG2205	protein histidine kinase activity
A9255_RS00850	COG3170	Tfp pilus assembly protein FimV
A9255_RS00855	COG2204	response regulator
A9255_RS00860	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A9255_RS00860	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
A9255_RS00865	COG0347	Belongs to the P(II) protein family
A9255_RS00870	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A9255_RS00870	COG1017	nitric oxide dioxygenase activity
A9255_RS00875	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A9255_RS00880	COG2814	Major facilitator Superfamily
A9255_RS00890	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
A9255_RS00895	COG1959	2 iron, 2 sulfur cluster binding
A9255_RS00900	COG1104	cysteine desulfurase activity
A9255_RS00905	COG0822	iron-sulfur transferase activity
A9255_RS00910	COG0316	Belongs to the HesB IscA family
A9255_RS00920	COG0443	Heat shock 70 kDa protein
A9255_RS00925	COG0633	Ferredoxin
A9255_RS00930	COG2975	iron-sulfur cluster assembly
A9255_RS00935	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A9255_RS00945	COG2373	Large extracellular alpha-helical protein
A9255_RS00950	COG4953	penicillin-binding protein 1C
A9255_RS00960	COG3655	Transcriptional regulator
A9255_RS00970	COG0105	UTP biosynthetic process
A9255_RS00975	COG0820	rRNA (adenine-C2-)-methyltransferase activity
A9255_RS00990	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
A9255_RS00995	COG0124	histidyl-tRNA synthetase
A9255_RS01000	COG2976	Protein conserved in bacteria
A9255_RS01005	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A9255_RS01010	COG1160	GTP binding
A9255_RS01030	COG0408	coproporphyrinogen oxidase activity
A9255_RS01035	COG0456	acetyltransferase
A9255_RS01050	COG4150	thiosulfate binding
A9255_RS01055	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
A9255_RS01060	COG4208	sulfate ABC transporter
A9255_RS01065	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
A9255_RS01080	COG2190	(PTS) system
A9255_RS01090	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A9255_RS01095	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A9255_RS01105	COG3115	cell septum assembly
A9255_RS01110	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A9255_RS01115	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A9255_RS01120	COG3530	Putative quorum-sensing-regulated virulence factor
A9255_RS01135	COG2062	phosphohistidine phosphatase, SixA
A9255_RS01140	COG1024	Enoyl-CoA hydratase
A9255_RS01140	COG1250	3-hydroxyacyl-CoA dehydrogenase
A9255_RS01145	COG0183	Belongs to the thiolase family
A9255_RS01150	COG3691	Protein conserved in bacteria
A9255_RS01175	COG0582	viral genome integration into host DNA
A9255_RS01230	COG3423	Transcriptional regulator
A9255_RS01250	COG0727	PFAM Uncharacterised protein family (UPF0153)
A9255_RS01310	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A9255_RS01385	COG2840	Smr protein MutS2
A9255_RS01390	COG1228	amidohydrolase
A9255_RS01405	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
A9255_RS01410	COG2986	histidine ammonia-lyase
A9255_RS01425	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
A9255_RS01430	COG0730	response to heat
A9255_RS01435	COG3101	peptidyl-lysine hydroxylation
A9255_RS01455	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A9255_RS01455	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
A9255_RS01460	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A9255_RS01485	COG0642	Histidine kinase
A9255_RS01490	COG0697	spore germination
A9255_RS01500	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A9255_RS01505	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A9255_RS01510	COG0101	tRNA pseudouridine synthase activity
A9255_RS01515	COG0586	Pfam SNARE associated Golgi protein
A9255_RS01520	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
A9255_RS01525	COG0285	dihydrofolate synthase activity
A9255_RS01530	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
A9255_RS01535	COG1286	toxin biosynthetic process
A9255_RS01540	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
A9255_RS01545	COG0163	prenyltransferase activity
A9255_RS01550	COG1090	epimerase
A9255_RS01555	COG0625	glutathione transferase activity
A9255_RS01565	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A9255_RS01590	COG2070	2-Nitropropane dioxygenase
A9255_RS01590	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
A9255_RS01595	COG1028	Short-chain dehydrogenase reductase Sdr
A9255_RS01605	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A9255_RS01625	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A9255_RS01630	COG1131	(ABC) transporter
A9255_RS01675	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A9255_RS01680	COG3138	arginine N-succinyltransferase
A9255_RS01685	COG1012	belongs to the aldehyde dehydrogenase family
A9255_RS01690	COG3724	N-succinylarginine dihydrolase activity
A9255_RS01695	COG2988	succinylglutamate desuccinylase activity
A9255_RS01700	COG1113	amino acid transport
A9255_RS01715	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A9255_RS01720	COG0857	belongs to the CobB CobQ family
A9255_RS01720	COG0280	phosphate acetyltransferase
A9255_RS01725	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
A9255_RS01735	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A9255_RS01740	COG0471	metal ion transport
A9255_RS01740	COG0490	domain, Protein
A9255_RS01745	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
A9255_RS01750	COG0436	Aminotransferase
A9255_RS01755	COG0583	DNA-binding transcription factor activity
A9255_RS01760	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A9255_RS01765	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A9255_RS01770	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A9255_RS01770	COG0649	NAD binding
A9255_RS01785	COG1034	ATP synthesis coupled electron transport
A9255_RS01790	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
A9255_RS01795	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A9255_RS01800	COG0839	Belongs to the complex I subunit 6 family
A9255_RS01805	COG0713	ATP synthesis coupled electron transport
A9255_RS01810	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A9255_RS01815	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A9255_RS01820	COG1007	ATP synthesis coupled electron transport
A9255_RS01830	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A9255_RS01865	COG3545	Serine hydrolase
A9255_RS01880	COG1304	FMN binding
A9255_RS01900	COG3549	Plasmid maintenance system killer
A9255_RS01905	COG3093	addiction module antidote protein HigA
A9255_RS01915	COG1560	Kdo2-lipid A biosynthetic process
A9255_RS01945	COG1054	Belongs to the UPF0176 family
A9255_RS01955	COG0418	dihydroorotase activity
A9255_RS02005	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
A9255_RS02015	COG0643	Histidine kinase
A9255_RS02015	COG2198	Histidine kinase
A9255_RS02020	COG0835	chemotaxis
A9255_RS02025	COG0840	transmembrane signaling receptor activity
A9255_RS02030	COG0840	transmembrane signaling receptor activity
A9255_RS02035	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
A9255_RS02040	COG2201	protein-glutamate methylesterase activity
A9255_RS02045	COG0745	RESPONSE REGULATOR receiver
A9255_RS02050	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
A9255_RS02065	COG3111	PFAM Bacterial OB fold (BOF) protein
A9255_RS02070	COG1115	amino acid carrier protein
A9255_RS02075	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A9255_RS02110	COG1815	bacterial-type flagellum-dependent cell motility
A9255_RS02115	COG1558	bacterial-type flagellum-dependent cell motility
A9255_RS02140	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
A9255_RS02145	COG1706	bacterial-type flagellum-dependent cell motility
A9255_RS02160	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A9255_RS02215	COG3121	Chaperone
A9255_RS02245	COG1028	Short-chain dehydrogenase reductase Sdr
A9255_RS02260	COG1338	Plays a role in the flagellum-specific transport system
A9255_RS02280	COG1580	Controls the rotational direction of flagella during chemotaxis
A9255_RS02295	COG1157	protein secretion by the type III secretion system
A9255_RS02300	COG1317	bacterial-type flagellum organization
A9255_RS02305	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A9255_RS02310	COG1766	The M ring may be actively involved in energy transduction
A9255_RS02315	COG1677	Flagellar hook-basal body complex protein FliE
A9255_RS02355	COG1191	sigma factor activity
A9255_RS02365	COG0506	proline dehydrogenase activity
A9255_RS02365	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
A9255_RS02365	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
A9255_RS02370	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A9255_RS02555	COG0582	viral genome integration into host DNA
A9255_RS02565	COG1113	amino acid transport
A9255_RS02590	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
A9255_RS02600	COG0583	DNA-binding transcription factor activity
A9255_RS02605	COG0697	spore germination
A9255_RS02625	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
A9255_RS02645	COG2197	response regulator
A9255_RS02650	COG0322	excinuclease ABC activity
A9255_RS02655	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A9255_RS02715	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
A9255_RS02735	COG3501	Rhs element vgr protein
A9255_RS02745	COG0010	Belongs to the arginase family
A9255_RS02765	COG1690	Belongs to the RtcB family
A9255_RS02770	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
A9255_RS02785	COG1115	amino acid carrier protein
A9255_RS02790	COG3023	N-Acetylmuramoyl-L-alanine amidase
A9255_RS02795	COG2207	Transcriptional regulator
A9255_RS02795	COG3708	Transcriptional regulator
A9255_RS02800	COG1113	amino acid transport
A9255_RS02815	COG0351	phosphomethylpyrimidine kinase
A9255_RS02820	COG1830	Aldolase
A9255_RS02825	COG0826	peptidase U32
A9255_RS02830	COG3422	double-strand break repair
A9255_RS02835	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A9255_RS02840	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A9255_RS02845	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A9255_RS02855	COG3157	Type VI secretion system effector, Hcp
A9255_RS02860	COG2239	Acts as a magnesium transporter
A9255_RS02870	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
A9255_RS02875	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A9255_RS02880	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
A9255_RS02885	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
A9255_RS02930	COG3723	Recombinational DNA repair protein, rece pathway
A9255_RS02935	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A9255_RS03000	COG1846	Transcriptional regulator
A9255_RS03050	COG0484	heat shock protein binding
A9255_RS03080	COG3772	lysozyme
A9255_RS03235	COG1192	Involved in chromosome partitioning
A9255_RS03300	COG5301	cellulose 1,4-beta-cellobiosidase activity
A9255_RS03315	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
A9255_RS03320	COG2233	PERMEase
A9255_RS03335	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A9255_RS03340	COG1393	Belongs to the ArsC family
A9255_RS03345	COG4783	chaperone-mediated protein folding
A9255_RS03350	COG0628	permease
A9255_RS03355	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A9255_RS03360	COG2716	regulation of RNA biosynthetic process
A9255_RS03365	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A9255_RS03370	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
A9255_RS03375	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
A9255_RS03385	COG2707	UPF0756 membrane protein
A9255_RS03390	COG1444	tRNA N-acetyltransferase activity
A9255_RS03395	COG1876	peptidase activity
A9255_RS03400	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A9255_RS03405	COG1393	Belongs to the ArsC family
A9255_RS03410	COG2197	response regulator
A9255_RS03430	COG1770	oligopeptidase
A9255_RS03435	COG1629	transport
A9255_RS03435	COG4206	TonB-dependent receptor
A9255_RS03440	COG1570	exodeoxyribonuclease VII activity
A9255_RS03445	COG0517	IMP dehydrogenase activity
A9255_RS03445	COG0516	GMP reductase activity
A9255_RS03450	COG0519	Catalyzes the synthesis of GMP from XMP
A9255_RS03450	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A9255_RS03455	COG0582	viral genome integration into host DNA
A9255_RS03510	COG4139	cobalamin transport
A9255_RS03515	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A9255_RS03545	COG3850	Histidine kinase
A9255_RS03555	COG1294	oxidase, subunit
A9255_RS03560	COG1271	oxidase subunit
A9255_RS03570	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A9255_RS03620	COG0814	amino acid
A9255_RS03630	COG4974	Belongs to the 'phage' integrase family
A9255_RS03695	COG2072	flavoprotein involved in K transport
A9255_RS03705	COG2144	transferase activity, transferring acyl groups
A9255_RS03730	COG3604	Transcriptional regulator
A9255_RS03745	COG1187	pseudouridine synthase activity
A9255_RS03765	COG0500	methyltransferase
A9255_RS03780	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A9255_RS03840	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A9255_RS03845	COG1301	dicarboxylic acid transport
A9255_RS03855	COG3739	integral membrane protein
A9255_RS03860	COG3196	Protein conserved in bacteria
A9255_RS03885	COG1012	belongs to the aldehyde dehydrogenase family
A9255_RS03905	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A9255_RS03910	COG3152	Membrane
A9255_RS03915	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A9255_RS03970	COG0406	alpha-ribazole phosphatase activity
A9255_RS03975	COG1982	Orn Lys Arg decarboxylase major
A9255_RS03980	COG0531	amino acid
A9255_RS03985	COG2814	Major facilitator Superfamily
A9255_RS03990	COG0583	DNA-binding transcription factor activity
A9255_RS04025	COG0589	response to stress
A9255_RS04040	COG2356	endonuclease I
A9255_RS04045	COG1702	phosphate starvation-inducible protein PhoH
A9255_RS04080	COG5301	cellulose 1,4-beta-cellobiosidase activity
A9255_RS04085	COG2267	carboxylic ester hydrolase activity
A9255_RS04090	COG0012	GTP binding
A9255_RS04095	COG0193	aminoacyl-tRNA hydrolase activity
A9255_RS04115	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A9255_RS04120	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
A9255_RS04125	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
A9255_RS04130	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
A9255_RS04135	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A9255_RS04140	COG2890	protein-(glutamine-N5) methyltransferase activity
A9255_RS04145	COG2912	Transglutaminase-like superfamily
A9255_RS04150	COG2877	3-deoxy-8-phosphooctulonate synthase activity
A9255_RS04155	COG0659	secondary active sulfate transmembrane transporter activity
A9255_RS04190	COG0156	8-amino-7-oxononanoate synthase activity
A9255_RS04200	COG4569	acetaldehyde dehydrogenase (acetylating) activity
A9255_RS04205	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A9255_RS04225	COG2453	phosphatase
A9255_RS04225	COG0671	phosphoesterase, PA-phosphatase related
A9255_RS04235	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A9255_RS04245	COG2378	regulation of single-species biofilm formation
A9255_RS04280	COG1960	acyl-CoA dehydrogenase activity
A9255_RS04285	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A9255_RS04295	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A9255_RS04300	COG0076	glutamate decarboxylase activity
A9255_RS04330	COG3321	synthase
A9255_RS04330	COG1028	Short-chain dehydrogenase reductase Sdr
A9255_RS04330	COG0604	alcohol dehydrogenase
A9255_RS04345	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A9255_RS04350	COG3381	protein complex oligomerization
A9255_RS04360	COG0477	Major facilitator Superfamily
A9255_RS04365	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A9255_RS04370	COG0728	peptidoglycan biosynthetic process
A9255_RS04375	COG0018	arginyl-trna synthetase
A9255_RS04380	COG3102	Protein conserved in bacteria
A9255_RS04385	COG3142	Participates in the control of copper homeostasis
A9255_RS04390	COG0500	methyltransferase
A9255_RS04395	COG2226	methyltransferase
A9255_RS04400	COG3788	relative of glutathione S-transferase, MAPEG superfamily
A9255_RS04405	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
A9255_RS04410	COG0494	nUDIX hydrolase
A9255_RS04415	COG0217	transcriptional regulatory protein
A9255_RS04420	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
A9255_RS04425	COG0632	four-way junction helicase activity
A9255_RS04430	COG2255	four-way junction helicase activity
A9255_RS04435	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A9255_RS04440	COG1121	(ABC) transporter
A9255_RS04445	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
A9255_RS04450	COG0739	heme binding
A9255_RS04455	COG1560	Kdo2-lipid A biosynthetic process
A9255_RS04460	COG0469	pyruvate kinase activity
A9255_RS04465	COG1737	Transcriptional regulator
A9255_RS04470	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
A9255_RS04480	COG2076	Multidrug Resistance protein
A9255_RS04485	COG2076	Multidrug Resistance protein
A9255_RS04490	COG0251	oxidation-reduction process
A9255_RS04495	COG1199	ATP-dependent helicase activity
A9255_RS04505	COG3065	identical protein binding
A9255_RS04510	COG0318	PFAM AMP-dependent synthetase and ligase
A9255_RS04515	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
A9255_RS04520	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
A9255_RS04525	COG2894	cell division
A9255_RS04530	COG0850	regulation of cytokinetic process
A9255_RS04535	COG3100	YcgL domain-containing protein
A9255_RS04540	COG2951	lytic endotransglycosylase activity
A9255_RS04545	COG0179	Fumarylacetoacetate (FAA) hydrolase
A9255_RS04550	COG2983	Belongs to the UPF0260 family
A9255_RS04575	COG2267	carboxylic ester hydrolase activity
A9255_RS04585	COG3187	Heat shock protein
A9255_RS04590	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A9255_RS04595	COG2911	Protein conserved in bacteria
A9255_RS04605	COG3784	Protein of unknown function (DUF1318)
A9255_RS04615	COG1643	Atp-dependent helicase
A9255_RS04625	COG3188	usher protein
A9255_RS04630	COG3121	Chaperone
A9255_RS04640	COG0531	amino acid
A9255_RS04840	COG5301	cellulose 1,4-beta-cellobiosidase activity
A9255_RS04850	COG5301	cellulose 1,4-beta-cellobiosidase activity
A9255_RS04855	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
A9255_RS04860	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
A9255_RS04870	COG1021	2,3-dihydroxybenzoate-AMP ligase
A9255_RS04890	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A9255_RS04890	COG2226	methyltransferase
A9255_RS04890	COG3433	isochorismatase activity
A9255_RS04895	COG1132	(ABC) transporter
A9255_RS04900	COG2375	cellular response to nickel ion
A9255_RS04900	COG1132	(ABC) transporter
A9255_RS04910	COG4771	TonB-dependent receptor
A9255_RS04925	COG4974	Belongs to the 'phage' integrase family
A9255_RS04950	COG0589	response to stress
A9255_RS04955	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A9255_RS05150	COG4626	Terminase
A9255_RS05150	COG1802	Transcriptional regulator
A9255_RS05265	COG2814	Major facilitator Superfamily
A9255_RS05295	COG0477	Major facilitator Superfamily
A9255_RS05315	COG0697	spore germination
A9255_RS05370	COG0697	spore germination
A9255_RS05375	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A9255_RS05385	COG1902	pentaerythritol trinitrate reductase activity
A9255_RS05395	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A9255_RS05435	COG1671	Belongs to the UPF0178 family
A9255_RS05480	COG4221	oxidoreductase activity
A9255_RS05495	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
A9255_RS05500	COG1940	carbohydrate kinase activity
A9255_RS05505	COG0583	DNA-binding transcription factor activity
A9255_RS05510	COG2814	Major facilitator Superfamily
A9255_RS05525	COG0114	fumarate hydratase activity
A9255_RS05530	COG1482	cell wall glycoprotein biosynthetic process
A9255_RS05535	COG5339	Protein conserved in bacteria
A9255_RS05540	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
A9255_RS05545	COG0385	Bile acid
A9255_RS05550	COG0673	inositol 2-dehydrogenase activity
A9255_RS05560	COG4657	Part of a membrane complex involved in electron transport
A9255_RS05580	COG4659	FMN binding
A9255_RS05590	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A9255_RS05605	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
A9255_RS05615	COG0023	Translation Initiation Factor
A9255_RS05620	COG0284	orotidine-5'-phosphate decarboxylase activity
A9255_RS05625	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
A9255_RS05630	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
A9255_RS05640	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
A9255_RS05655	COG0583	DNA-binding transcription factor activity
A9255_RS05670	COG0616	signal peptide processing
A9255_RS05675	COG1028	Short-chain dehydrogenase reductase Sdr
A9255_RS05680	COG1187	pseudouridine synthase activity
A9255_RS05685	COG0009	L-threonylcarbamoyladenylate synthase
A9255_RS05705	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A9255_RS05710	COG0135	phosphoribosylanthranilate isomerase activity
A9255_RS05710	COG0134	indole-3-glycerol-phosphate synthase activity
A9255_RS05715	COG0133	tryptophan synthase activity
A9255_RS05720	COG0159	tryptophan synthase activity
A9255_RS05725	COG3047	cAMP biosynthetic process
A9255_RS05740	COG2917	probably involved in intracellular septation
A9255_RS05780	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
A9255_RS05785	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A9255_RS05790	COG3099	Belongs to the UPF0263 family
A9255_RS05800	COG0444	Belongs to the ABC transporter superfamily
A9255_RS05805	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A9255_RS05825	COG2095	MarC family integral membrane protein
A9255_RS05830	COG1012	belongs to the aldehyde dehydrogenase family
A9255_RS05830	COG1454	alcohol dehydrogenase
A9255_RS05835	COG1435	thymidine kinase activity
A9255_RS05840	COG2916	Histone family protein nucleoid-structuring protein H-NS
A9255_RS05855	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A9255_RS05860	COG0745	RESPONSE REGULATOR receiver
A9255_RS05865	COG3012	SEC-C Motif Domain Protein
A9255_RS05870	COG0788	formyltetrahydrofolate deformylase activity
A9255_RS05890	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A9255_RS06055	COG5484	DNA packaging
A9255_RS06055	COG3728	DNA packaging
A9255_RS06095	COG3772	lysozyme
A9255_RS06130	COG0484	heat shock protein binding
A9255_RS06180	COG2974	May be involved in recombination
A9255_RS06190	COG1846	Transcriptional regulator
A9255_RS06240	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A9255_RS06290	COG0582	viral genome integration into host DNA
A9255_RS06295	COG0778	Nitroreductase
A9255_RS06300	COG0616	signal peptide processing
A9255_RS06305	COG0252	asparaginase activity
A9255_RS06310	COG1335	isochorismatase
A9255_RS06315	COG5301	cellulose 1,4-beta-cellobiosidase activity
A9255_RS06355	COG3139	Protein of unknown function (DUF1315)
A9255_RS06375	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A9255_RS06380	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A9255_RS06475	COG2186	Transcriptional regulator
A9255_RS06480	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A9255_RS06485	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
A9255_RS06490	COG0037	tRNA processing
A9255_RS06495	COG0598	Magnesium transport protein CorA
A9255_RS06500	COG4166	transmembrane transport
A9255_RS06545	COG1360	Flagellar Motor Protein
A9255_RS06600	COG0515	serine threonine protein kinase
A9255_RS06615	COG3106	COG3106 Predicted ATPase
A9255_RS06620	COG1983	PspC domain protein
A9255_RS06630	COG1842	Phage shock protein A
A9255_RS06635	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
A9255_RS06640	COG4166	transmembrane transport
A9255_RS06650	COG4171	peptide transport system, permease
A9255_RS06680	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
A9255_RS06685	COG0259	pyridoxamine-phosphate oxidase activity
A9255_RS06690	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
A9255_RS06695	COG3133	Outer membrane lipoprotein
A9255_RS06705	COG3313	Fe-S protein
A9255_RS06710	COG0346	lactoylglutathione lyase activity
A9255_RS06720	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
A9255_RS06730	COG1609	Transcriptional regulator
A9255_RS06735	COG0583	DNA-binding transcription factor activity
A9255_RS06740	COG2814	Major facilitator Superfamily
A9255_RS06745	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A9255_RS06750	COG0307	riboflavin synthase, alpha
A9255_RS06755	COG0534	Mate efflux family protein
A9255_RS06775	COG4238	major outer membrane lipoprotein
A9255_RS06780	COG1376	ErfK ybiS ycfS ynhG family protein
A9255_RS06780	COG1388	LysM domain
A9255_RS06785	COG2050	protein possibly involved in aromatic compounds catabolism
A9255_RS06790	COG0277	FAD linked oxidase domain protein
A9255_RS06790	COG0247	lactate metabolic process
A9255_RS06795	COG0628	permease
A9255_RS06800	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A9255_RS06800	COG0574	Belongs to the PEP-utilizing enzyme family
A9255_RS06805	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
A9255_RS06810	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A9255_RS06815	COG4771	TonB-dependent receptor
A9255_RS06820	COG3720	iron ion transport
A9255_RS06825	COG4558	Periplasmic binding protein
A9255_RS06830	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A9255_RS06835	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
A9255_RS06840	COG2207	Transcriptional regulator
A9255_RS06845	COG0095	Lipoate-protein ligase
A9255_RS06850	COG0791	NLP P60 protein
A9255_RS06855	COG2076	Multidrug Resistance protein
A9255_RS06860	COG2076	Multidrug Resistance protein
A9255_RS06865	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
A9255_RS06870	COG0726	polysaccharide deacetylase
A9255_RS06875	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A9255_RS06875	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A9255_RS06880	COG0463	Glycosyl transferase, family 2
A9255_RS06885	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A9255_RS06890	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
A9255_RS06895	COG4139	cobalamin transport
A9255_RS06900	COG0776	regulation of translation
A9255_RS06905	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A9255_RS06905	COG0072	phenylalanine-tRNA ligase activity
A9255_RS06920	COG0291	Belongs to the bacterial ribosomal protein bL35 family
A9255_RS06925	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
A9255_RS06930	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A9255_RS06950	COG0741	lytic transglycosylase activity
A9255_RS06955	COG0803	Belongs to the bacterial solute-binding protein 9 family
A9255_RS06960	COG1121	(ABC) transporter
A9255_RS06965	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A9255_RS06970	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A9255_RS06975	COG3001	Fructosamine kinase
A9255_RS06985	COG1988	membrane-bound metal-dependent
A9255_RS06990	COG1823	symporter activity
A9255_RS06995	COG0501	Belongs to the peptidase M48B family
A9255_RS07005	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
A9255_RS07010	COG1956	GAF domain-containing protein
A9255_RS07020	COG1276	copper resistance
A9255_RS07025	COG2372	response to copper ion
A9255_RS07030	COG1528	Iron-storage protein
A9255_RS07050	COG3140	Belongs to the UPF0181 family
A9255_RS07055	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A9255_RS07060	COG0494	nUDIX hydrolase
A9255_RS07065	COG1760	l-serine dehydratase
A9255_RS07070	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
A9255_RS07070	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A9255_RS07075	COG3715	PTS system
A9255_RS07080	COG3716	PTS system mannose fructose sorbose family IID component
A9255_RS07085	COG4811	Protein of unknown function (DUF986)
A9255_RS07090	COG1971	Probably functions as a manganese efflux pump
A9255_RS07095	COG2226	methyltransferase
A9255_RS07105	COG2271	Major facilitator Superfamily
A9255_RS07115	COG3851	Histidine kinase
A9255_RS07120	COG2197	response regulator
A9255_RS07130	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A9255_RS07160	COG3547	Transposase (IS116 IS110 IS902 family)
A9255_RS07185	COG0583	DNA-binding transcription factor activity
A9255_RS07205	COG0473	3-isopropylmalate dehydrogenase activity
A9255_RS07205	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
A9255_RS07210	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
A9255_RS07210	COG0473	3-isopropylmalate dehydrogenase activity
A9255_RS07220	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A9255_RS07225	COG2814	Major facilitator Superfamily
A9255_RS07370	COG3772	lysozyme
A9255_RS07515	COG0582	viral genome integration into host DNA
A9255_RS07520	COG0538	isocitrate dehydrogenase activity
A9255_RS07525	COG1187	pseudouridine synthase activity
A9255_RS07535	COG0482	sulfurtransferase activity
A9255_RS07540	COG2915	High frequency lysogenization protein hflD homolog
A9255_RS07545	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A9255_RS07550	COG0745	RESPONSE REGULATOR receiver
A9255_RS07555	COG2205	protein histidine kinase activity
A9255_RS07565	COG2850	peptidyl-arginine hydroxylation
A9255_RS07575	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
A9255_RS07580	COG4591	ABC-type transport system involved in lipoprotein release permease component
A9255_RS07585	COG1136	(ABC) transporter
A9255_RS07590	COG4591	ABC-type transport system involved in lipoprotein release permease component
A9255_RS07600	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A9255_RS07605	COG3134	Outer membrane lipoprotein
A9255_RS07610	COG1252	NADH dehydrogenase
A9255_RS07615	COG1472	Belongs to the glycosyl hydrolase 3 family
A9255_RS07625	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
A9255_RS07630	COG0537	adenosine 5'-monophosphoramidase activity
A9255_RS07635	COG0084	hydrolase, TatD family'
A9255_RS07640	COG0470	DNA polymerase III
A9255_RS07645	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A9255_RS07650	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A9255_RS07655	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A9255_RS07660	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A9255_RS07665	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A9255_RS07675	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
A9255_RS07680	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A9255_RS07685	COG0416	fatty acid biosynthetic process
A9255_RS07690	COG0333	Belongs to the bacterial ribosomal protein bL32 family
A9255_RS07695	COG1399	metal-binding, possibly nucleic acid-binding protein
A9255_RS07700	COG0424	maF-like protein
A9255_RS07705	COG0564	pseudouridine synthase activity
A9255_RS07710	COG1530	ribonuclease E activity
A9255_RS07715	COG0702	epimerase
A9255_RS07720	COG2926	Belongs to the UPF0265 family
A9255_RS07745	COG4381	Mu-like prophage protein gp46
A9255_RS07800	COG4386	tail sheath protein
A9255_RS07895	COG3772	lysozyme
A9255_RS08060	COG0582	viral genome integration into host DNA
A9255_RS08065	COG2925	Exonuclease
A9255_RS08070	COG0277	FAD linked oxidase domain protein
A9255_RS08075	COG0531	amino acid
A9255_RS08080	COG4771	TonB-dependent receptor
A9255_RS08090	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A9255_RS08100	COG0833	amino acid
A9255_RS08105	COG0583	DNA-binding transcription factor activity
A9255_RS08110	COG2855	membrane
A9255_RS08115	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
A9255_RS08120	COG1105	Belongs to the carbohydrate kinase PfkB family
A9255_RS08125	COG0494	nUDIX hydrolase
A9255_RS08135	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A9255_RS08155	COG0671	phosphoesterase, PA-phosphatase related
A9255_RS08160	COG0791	NLP P60 protein
A9255_RS08170	COG2814	Major facilitator Superfamily
A9255_RS08175	COG1187	pseudouridine synthase activity
A9255_RS08180	COG1061	Type III restriction enzyme res subunit
A9255_RS08190	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
A9255_RS08195	COG3081	Nucleoid-associated protein
A9255_RS08200	COG3082	Protein of unknown function (DUF1414)
A9255_RS08235	COG5301	cellulose 1,4-beta-cellobiosidase activity
A9255_RS08315	COG3397	chitin binding
A9255_RS08320	COG0346	lactoylglutathione lyase activity
A9255_RS08335	COG0625	glutathione transferase activity
A9255_RS08340	COG3023	N-Acetylmuramoyl-L-alanine amidase
A9255_RS08345	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A9255_RS08355	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A9255_RS08360	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A9255_RS08370	COG2205	protein histidine kinase activity
A9255_RS08370	COG0784	Response regulator, receiver
A9255_RS08375	COG2197	response regulator
A9255_RS08380	COG0642	Histidine kinase
A9255_RS08380	COG2198	Histidine kinase
A9255_RS08395	COG0814	amino acid
A9255_RS08410	COG1441	menaquinone biosynthetic process
A9255_RS08415	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
A9255_RS08420	COG0596	Alpha beta hydrolase
A9255_RS08425	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
A9255_RS08430	COG3539	Fimbrial protein
A9255_RS08440	COG3121	Chaperone
A9255_RS08465	COG2199	diguanylate cyclase activity
A9255_RS08470	COG2885	chlorophyll binding
A9255_RS08555	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
A9255_RS08580	COG3561	AntA/AntB antirepressor
A9255_RS08605	COG2920	part of a sulfur-relay system
A9255_RS08610	COG1254	Belongs to the acylphosphatase family
A9255_RS08615	COG3785	DNA binding
A9255_RS08620	COG1832	CoA-binding protein
A9255_RS08630	COG0210	DNA helicase
A9255_RS08635	COG1289	transmembrane transporter activity
A9255_RS08655	COG3120	sequence-specific DNA binding
A9255_RS08660	COG1067	ATP-dependent peptidase activity
A9255_RS08665	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A9255_RS08670	COG3130	regulation of translation
A9255_RS08675	COG3009	Protein conserved in bacteria
A9255_RS08680	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
A9255_RS08680	COG3008	intermembrane lipid transfer
A9255_RS08685	COG2995	paraquat-inducible protein a
A9255_RS08690	COG0488	(ABC) transporter
A9255_RS08695	COG0116	Belongs to the methyltransferase superfamily
A9255_RS08695	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A9255_RS08700	COG3217	Mosc domain protein beta barrel domain protein
A9255_RS08700	COG0633	Ferredoxin
A9255_RS08710	COG0167	dihydroorotate dehydrogenase activity
A9255_RS08715	COG0308	aminopeptidase N
A9255_RS08720	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
A9255_RS08725	COG0017	Asparaginyl-tRNA synthetase
A9255_RS08730	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
A9255_RS08735	COG1448	Aminotransferase
A9255_RS08740	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A9255_RS08745	COG3108	Peptidase M15
A9255_RS08750	COG2989	Protein conserved in bacteria
A9255_RS08755	COG3700	Belongs to the class B bacterial acid phosphatase family
A9255_RS08765	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
A9255_RS08770	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
A9255_RS08775	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
A9255_RS08780	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
A9255_RS08785	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A9255_RS08790	COG1434	Gram-negative-bacterium-type cell wall biogenesis
A9255_RS08795	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
A9255_RS08800	COG2835	tetraacyldisaccharide 4'-kinase activity
A9255_RS08805	COG1663	tetraacyldisaccharide 4'-kinase activity
A9255_RS08810	COG1132	(ABC) transporter
A9255_RS08815	COG2333	competence protein COMEC
A9255_RS08815	COG0658	competence protein
A9255_RS08825	COG0539	negative regulation of cytoplasmic translation
A9255_RS08830	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
A9255_RS08835	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
A9255_RS08840	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
A9255_RS08855	COG0252	asparaginase activity
A9255_RS08860	COG1944	ATP diphosphatase activity
A9255_RS08865	COG2116	formate transmembrane transporter activity
A9255_RS08870	COG1882	Formate acetyltransferase
A9255_RS08875	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
A9255_RS08885	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
A9255_RS08890	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A9255_RS08895	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
A9255_RS08900	COG1674	ftsk spoiiie
A9255_RS08900	COG3107	peptidoglycan biosynthetic process
A9255_RS08905	COG1522	sequence-specific DNA binding
A9255_RS08910	COG0492	ferredoxin-NADP+ reductase activity
A9255_RS08920	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
A9255_RS08925	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
A9255_RS08930	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
A9255_RS08935	COG0542	response to heat
A9255_RS08940	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
A9255_RS08945	COG1278	Cold shock
A9255_RS08950	COG1136	(ABC) transporter
A9255_RS08950	COG0577	efflux transmembrane transporter activity
A9255_RS08955	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A9255_RS08960	COG3593	DNA synthesis involved in DNA repair
A9255_RS08965	COG2431	L-lysine efflux transmembrane transporter activity
A9255_RS08970	COG1126	abc transporter atp-binding protein
A9255_RS08975	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A9255_RS08980	COG4215	(ABC) transporter
A9255_RS08985	COG4160	amino acid transport
A9255_RS08990	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A9255_RS09010	COG0671	phosphoesterase, PA-phosphatase related
A9255_RS09015	COG0814	amino acid
A9255_RS09020	COG1686	Belongs to the peptidase S11 family
A9255_RS09025	COG0625	glutathione transferase activity
A9255_RS09030	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A9255_RS09035	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
A9255_RS09040	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A9255_RS09040	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
A9255_RS09045	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A9255_RS09045	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
A9255_RS09050	COG0131	Imidazoleglycerol-phosphate dehydratase
A9255_RS09050	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
A9255_RS09055	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
A9255_RS09060	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
A9255_RS09065	COG0107	imidazoleglycerol-phosphate synthase activity
A9255_RS09070	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
A9255_RS09070	COG0140	phosphoribosyl-ATP diphosphatase activity
A9255_RS09075	COG1454	alcohol dehydrogenase
A9255_RS09080	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
A9255_RS09090	COG1253	flavin adenine dinucleotide binding
A9255_RS09095	COG5301	cellulose 1,4-beta-cellobiosidase activity
A9255_RS09100	COG2982	Protein involved in outer membrane biogenesis
A9255_RS09105	COG0717	Belongs to the dCTP deaminase family
A9255_RS09110	COG0572	uridine kinase
A9255_RS09115	COG0489	protein tyrosine kinase activity
A9255_RS09120	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A9255_RS09120	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A9255_RS09125	COG1380	Effector of murein hydrolase LrgA
A9255_RS09130	COG1346	cytolysis
A9255_RS09135	COG0295	cytidine deaminase activity
A9255_RS09140	COG0281	malic enzyme
A9255_RS09145	COG2949	membrane
A9255_RS09150	COG2311	Membrane
A9255_RS09155	COG0302	gtp cyclohydrolase
A9255_RS09160	COG0477	Major facilitator Superfamily
A9255_RS09165	COG0303	'Molybdopterin
A9255_RS09170	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A9255_RS09175	COG0488	(ABC) transporter
A9255_RS09180	COG0673	inositol 2-dehydrogenase activity
A9255_RS09185	COG2807	transmembrane transport
A9255_RS09195	COG5006	permease, DMT superfamily
A9255_RS09215	COG2824	Alkylphosphonate utilization operon protein PhnA
A9255_RS09240	COG0488	(ABC) transporter
A9255_RS09250	COG2897	thiosulfate sulfurtransferase activity
A9255_RS09255	COG2261	transglycosylase associated protein
A9255_RS09270	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A9255_RS09275	COG0513	Belongs to the DEAD box helicase family
A9255_RS09280	COG1309	transcriptional regulator
A9255_RS09290	COG1131	(ABC) transporter
A9255_RS09295	COG0842	Transport permease protein
A9255_RS09300	COG0842	Transport permease protein
A9255_RS09310	COG0670	Belongs to the BI1 family
A9255_RS09315	COG0314	molybdopterin synthase activity
A9255_RS09320	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
A9255_RS09330	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A9255_RS09335	COG0391	Required for morphogenesis under gluconeogenic growth conditions
A9255_RS09340	COG0556	nucleotide-excision repair
A9255_RS09345	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
A9255_RS09350	COG2226	methyltransferase
A9255_RS09355	COG0156	8-amino-7-oxononanoate synthase activity
A9255_RS09360	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
A9255_RS09430	COG2706	6-phosphogluconolactonase activity
A9255_RS09435	COG0561	phosphatase activity
A9255_RS09440	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
A9255_RS09445	COG4149	molybdate abc transporter
A9255_RS09450	COG0725	ABC transporter, periplasmic molybdate-binding protein
A9255_RS09455	COG0477	Major facilitator Superfamily
A9255_RS09460	COG3585	molybdate ion transport
A9255_RS09460	COG2005	Transcriptional regulator
A9255_RS09465	COG1119	ATPase activity
A9255_RS09475	COG0588	phosphoglycerate mutase activity
A9255_RS09480	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A9255_RS09500	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
A9255_RS09505	COG2885	chlorophyll binding
A9255_RS09510	COG0823	Involved in the tonB-independent uptake of proteins
A9255_RS09515	COG3064	Membrane
A9255_RS09520	COG0848	biopolymer transport protein
A9255_RS09525	COG0811	peptide transport
A9255_RS09530	COG0824	Thioesterase
A9255_RS09535	COG3790	cyd operon protein YbgE
A9255_RS09540	COG4890	Cyd operon protein YbgT
A9255_RS09545	COG1294	oxidase, subunit
A9255_RS09550	COG1271	oxidase subunit
A9255_RS09565	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
A9255_RS09570	COG0045	succinate-CoA ligase (ADP-forming) activity
A9255_RS09575	COG0508	dehydrogenase complex catalyzes the overall conversion of
A9255_RS09580	COG0567	Dehydrogenase, E1 component
A9255_RS09585	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A9255_RS09590	COG1053	succinate dehydrogenase
A9255_RS09595	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
A9255_RS09605	COG0372	Belongs to the citrate synthase family
A9255_RS09610	COG1619	proteins homologs of microcin C7 resistance protein MccF
A9255_RS09620	COG2814	Major facilitator Superfamily
A9255_RS09625	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
A9255_RS09640	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
A9255_RS09645	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
A9255_RS09650	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
A9255_RS09655	COG2205	protein histidine kinase activity
A9255_RS09660	COG0745	RESPONSE REGULATOR receiver
A9255_RS09675	COG0033	Phosphoglucomutase
A9255_RS09680	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
A9255_RS09685	COG0596	Alpha beta hydrolase
A9255_RS09690	COG2226	methyltransferase
A9255_RS09715	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
A9255_RS09715	COG3064	Membrane
A9255_RS09715	COG1073	alpha beta
A9255_RS09720	COG2994	toxin metabolic process
A9255_RS09740	COG2274	protein secretion by the type I secretion system
A9255_RS09765	COG0662	Cupin 2, conserved barrel domain protein
A9255_RS09765	COG2207	Transcriptional regulator
A9255_RS09770	COG0582	viral genome integration into host DNA
A9255_RS09775	COG4932	domain protein
A9255_RS09775	COG2373	Large extracellular alpha-helical protein
A9255_RS09775	COG1388	LysM domain
A9255_RS09780	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A9255_RS09800	COG0716	FMN binding
A9255_RS09805	COG0735	belongs to the Fur family
A9255_RS09815	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A9255_RS09825	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A9255_RS09825	COG1263	PTS System
A9255_RS09825	COG2190	(PTS) system
A9255_RS09830	COG0363	glucosamine-6-phosphate deaminase activity
A9255_RS09835	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
A9255_RS09840	COG1846	Transcriptional regulator
A9255_RS09840	COG1940	carbohydrate kinase activity
A9255_RS09875	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A9255_RS09880	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A9255_RS09885	COG1702	phosphate starvation-inducible protein PhoH
A9255_RS09890	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
A9255_RS09895	COG4535	Mg2 and Co2 transporter CorC
A9255_RS09900	COG0815	Transfers the fatty acyl group on membrane lipoproteins
A9255_RS09910	COG0765	amino acid transport
A9255_RS09915	COG0765	amino acid transport
A9255_RS09920	COG1126	abc transporter atp-binding protein
A9255_RS09925	COG0495	leucyl-tRNA aminoacylation
A9255_RS09930	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
A9255_RS09935	COG1466	dna polymerase III delta subunit
A9255_RS09945	COG0799	negative regulation of ribosome biogenesis
A9255_RS09950	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
A9255_RS09955	COG0768	penicillin binding
A9255_RS09960	COG0772	Belongs to the SEDS family
A9255_RS09965	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A9255_RS09970	COG1686	Belongs to the peptidase S11 family
A9255_RS09975	COG2921	Belongs to the UPF0250 family
A9255_RS09995	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A9255_RS10000	COG0321	lipoyl(octanoyl) transferase activity
A9255_RS10005	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
A9255_RS10010	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A9255_RS10015	COG1278	Cold shock
A9255_RS10020	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A9255_RS10025	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
A9255_RS10035	COG1846	Transcriptional regulator
A9255_RS10040	COG1566	PFAM secretion protein HlyD family protein
A9255_RS10045	COG2814	Major facilitator Superfamily
A9255_RS10050	COG1605	Chorismate mutase
A9255_RS10055	COG0076	glutamate decarboxylase activity
A9255_RS10060	COG4114	ferric iron reductase
A9255_RS10065	COG1120	ATPase activity
A9255_RS10075	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A9255_RS10080	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A9255_RS10095	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A9255_RS10100	COG3148	PFAM DTW domain containing protein
A9255_RS10105	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A9255_RS10105	COG0045	succinate-CoA ligase (ADP-forming) activity
A9255_RS10105	COG1042	CoA-binding domain protein
A9255_RS10110	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A9255_RS10115	COG5544	Lipoprotein
A9255_RS10140	COG0542	response to heat
A9255_RS10145	COG1496	oxidoreductase activity
A9255_RS10150	COG0564	pseudouridine synthase activity
A9255_RS10155	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A9255_RS10160	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
A9255_RS10165	COG0077	Prephenate dehydratase
A9255_RS10165	COG1605	Chorismate mutase
A9255_RS10170	COG0287	Prephenate dehydrogenase
A9255_RS10170	COG1605	Chorismate mutase
A9255_RS10175	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A9255_RS10185	COG0335	large ribosomal subunit rRNA binding
A9255_RS10190	COG0336	Belongs to the RNA methyltransferase TrmD family
A9255_RS10195	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
A9255_RS10200	COG0228	four-way junction DNA binding
A9255_RS10205	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A9255_RS10210	COG4137	Cytochrome C assembly protein
A9255_RS10215	COG4536	flavin adenine dinucleotide binding
A9255_RS10230	COG1854	S-ribosylhomocysteine lyase activity
A9255_RS10235	COG2918	glutathione biosynthetic process
A9255_RS10260	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
A9255_RS10265	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A9255_RS10270	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
A9255_RS10280	COG2814	Major facilitator Superfamily
A9255_RS10285	COG0318	PFAM AMP-dependent synthetase and ligase
A9255_RS10285	COG0204	Acyl-transferase
A9255_RS10290	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
A9255_RS10295	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
A9255_RS10300	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
A9255_RS10310	COG1073	alpha beta
A9255_RS10315	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
A9255_RS10320	COG2195	Cleaves the N-terminal amino acid of tripeptides
A9255_RS10325	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A9255_RS10335	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A9255_RS10340	COG1309	transcriptional regulator
A9255_RS10345	COG1012	belongs to the aldehyde dehydrogenase family
A9255_RS10350	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
A9255_RS10370	COG1595	DNA-templated transcription, initiation
A9255_RS10375	COG2991	Protein conserved in bacteria
A9255_RS10380	COG1477	protein flavinylation
A9255_RS10390	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
A9255_RS10395	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
A9255_RS10400	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
A9255_RS10405	COG1805	sodium ion transport
A9255_RS10410	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
A9255_RS10415	COG3034	peptidoglycan biosynthetic process
A9255_RS10420	COG0121	glutamine amidotransferase
A9255_RS10425	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
A9255_RS10430	COG1960	acyl-CoA dehydrogenase activity
A9255_RS10440	COG0583	DNA-binding transcription factor activity
A9255_RS10445	COG0583	DNA-binding transcription factor activity
A9255_RS10450	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A9255_RS10470	COG1385	rRNA (uridine-N3-)-methyltransferase activity
A9255_RS10475	COG0189	ligase activity
A9255_RS10480	COG1678	Uncharacterized ACR, COG1678
A9255_RS10485	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
A9255_RS10490	COG2805	Type II/IV secretion system protein
A9255_RS10495	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
A9255_RS10500	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A9255_RS10505	COG0762	integral membrane protein
A9255_RS10510	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
A9255_RS10515	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A9255_RS10520	COG4607	ABC-type enterochelin transport system periplasmic component
A9255_RS10530	COG2066	Belongs to the glutaminase family
A9255_RS10535	COG3171	Protein conserved in bacteria
A9255_RS10540	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A9255_RS10545	COG1194	a g-specific adenine glycosylase
A9255_RS10550	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
A9255_RS10555	COG0741	lytic transglycosylase activity
A9255_RS10565	COG0582	viral genome integration into host DNA
A9255_RS10600	COG1028	Short-chain dehydrogenase reductase Sdr
A9255_RS10770	COG1028	Short-chain dehydrogenase reductase Sdr
A9255_RS10775	COG1535	isochorismatase
A9255_RS10775	COG3433	isochorismatase activity
A9255_RS10790	COG2814	Major facilitator Superfamily
A9255_RS10850	COG0443	Heat shock 70 kDa protein
A9255_RS10865	COG1309	transcriptional regulator
A9255_RS10880	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
A9255_RS10885	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
A9255_RS10890	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
A9255_RS10895	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A9255_RS10900	COG4974	Belongs to the 'phage' integrase family
A9255_RS10905	COG0716	FMN binding
A9255_RS10915	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
A9255_RS10920	COG0354	folic acid binding
A9255_RS10930	COG0477	Major facilitator Superfamily
A9255_RS10945	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A9255_RS10945	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A9255_RS10950	COG0509	glycine decarboxylation via glycine cleavage system
A9255_RS10955	COG0404	The glycine cleavage system catalyzes the degradation of glycine
A9255_RS10960	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A9255_RS10965	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A9255_RS10970	COG0006	proline dipeptidase activity
A9255_RS10975	COG3079	Belongs to the UPF0149 family
A9255_RS10990	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A9255_RS10995	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A9255_RS11000	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
A9255_RS11005	COG0583	DNA-binding transcription factor activity
A9255_RS11010	COG2968	Membrane
A9255_RS11015	COG1279	arginine transmembrane transporter activity
A9255_RS11020	COG0668	transmembrane transport
A9255_RS11025	COG3112	Uncharacterised protein family (UPF0231)
A9255_RS11035	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A9255_RS11040	COG0508	dehydrogenase complex catalyzes the overall conversion of
A9255_RS11045	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
A9255_RS11050	COG2186	Transcriptional regulator
A9255_RS11055	COG3725	Membrane protein required for beta-lactamase induction
A9255_RS11065	COG4969	Belongs to the N-Me-Phe pilin family
A9255_RS11070	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A9255_RS11075	COG1459	type II secretion system
A9255_RS11080	COG0237	dephospho-CoA kinase activity
A9255_RS11085	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
A9255_RS11090	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
A9255_RS11095	COG0494	nUDIX hydrolase
A9255_RS11100	COG0488	(ABC) transporter
A9255_RS11105	COG0653	protein targeting
A9255_RS11120	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
A9255_RS11130	COG0849	cell division
A9255_RS11135	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
A9255_RS11140	COG1181	Belongs to the D-alanine--D-alanine ligase family
A9255_RS11145	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A9255_RS11150	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A9255_RS11155	COG0772	Belongs to the SEDS family
A9255_RS11160	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
A9255_RS11165	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A9255_RS11170	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A9255_RS11175	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A9255_RS11180	COG0768	penicillin binding
A9255_RS11185	COG3116	cell division
A9255_RS11190	COG0275	rRNA processing
A9255_RS11210	COG0028	Belongs to the TPP enzyme family
A9255_RS11215	COG1022	Amp-dependent synthetase and ligase
A9255_RS11230	COG0473	3-isopropylmalate dehydrogenase activity
A9255_RS11235	COG4533	DNA binding
A9255_RS11240	COG3066	DNA modification
A9255_RS11245	COG3064	Membrane
A9255_RS11245	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
A9255_RS11245	COG1073	alpha beta
A9255_RS11250	COG1982	Orn Lys Arg decarboxylase major
A9255_RS11260	COG0242	peptide deformylase activity
A9255_RS11265	COG0626	cystathionine gamma-synthase activity
A9255_RS11285	COG4122	O-methyltransferase activity
A9255_RS11290	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A9255_RS11295	COG2977	Belongs to the P-Pant transferase superfamily
A9255_RS11300	COG0066	3-isopropylmalate dehydratase activity
A9255_RS11305	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
A9255_RS11310	COG0583	DNA-binding transcription factor activity
A9255_RS11320	COG1881	PFAM PEBP family protein
A9255_RS11325	COG0010	Belongs to the arginase family
A9255_RS11330	COG1166	arginine decarboxylase activity
A9255_RS11335	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
A9255_RS11340	COG3091	SprT-like family
A9255_RS11355	COG0563	adenylate kinase activity
A9255_RS11360	COG0326	Molecular chaperone. Has ATPase activity
A9255_RS11365	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
A9255_RS11370	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
A9255_RS11375	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A9255_RS11380	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A9255_RS11395	COG1196	nuclear chromosome segregation
A9255_RS11395	COG3264	Mechanosensitive ion channel
A9255_RS11400	COG1309	transcriptional regulator
A9255_RS11405	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A9255_RS11410	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A9255_RS11430	COG0004	ammonium transporteR
A9255_RS11435	COG0347	Belongs to the P(II) protein family
A9255_RS11440	COG1132	(ABC) transporter
A9255_RS11445	COG1132	(ABC) transporter
A9255_RS11450	COG1522	sequence-specific DNA binding
A9255_RS11460	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
A9255_RS11465	COG0824	Thioesterase
A9255_RS11470	COG1555	photosystem II stabilization
A9255_RS11475	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A9255_RS11480	COG0776	regulation of translation
A9255_RS11485	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
A9255_RS11490	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
A9255_RS11495	COG0740	serine-type endopeptidase activity
A9255_RS11500	COG0544	peptidyl-prolyl cis-trans isomerase activity
A9255_RS11505	COG0271	Belongs to the BolA IbaG family
A9255_RS11510	COG3056	Lipoprotein
A9255_RS11515	COG2223	nitrite transmembrane transporter activity
A9255_RS11525	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
A9255_RS11530	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A9255_RS11535	COG1845	cytochrome c oxidase, subunit III
A9255_RS11540	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
A9255_RS11545	COG0109	protoheme IX farnesyltransferase activity
A9255_RS11550	COG2814	Major facilitator Superfamily
A9255_RS11560	COG1666	GTP binding
A9255_RS11565	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
A9255_RS11570	COG0693	protein deglycase activity
A9255_RS11575	COG0301	tRNA thio-modification
A9255_RS11575	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A9255_RS11585	COG0142	geranyltranstransferase activity
A9255_RS11590	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
A9255_RS11640	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
A9255_RS11645	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
A9255_RS11650	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A9255_RS11655	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
A9255_RS11660	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A9255_RS11660	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A9255_RS11665	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
A9255_RS11670	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A9255_RS11680	COG1862	Preprotein translocase
A9255_RS11685	COG0343	queuine tRNA-ribosyltransferase activity
A9255_RS11690	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
A9255_RS11695	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
A9255_RS11700	COG0450	alkyl hydroperoxide reductase
A9255_RS11710	COG1114	Component of the transport system for branched-chain amino acids
A9255_RS11715	COG5002	protein histidine kinase activity
A9255_RS11720	COG0745	RESPONSE REGULATOR receiver
A9255_RS11725	COG0420	3'-5' exonuclease activity
A9255_RS11730	COG0419	ATPase involved in DNA repair
A9255_RS11765	COG3719	Belongs to the RNase T2 family
A9255_RS11770	COG0737	Belongs to the 5'-nucleotidase family
A9255_RS11780	COG1940	carbohydrate kinase activity
A9255_RS11785	COG2974	May be involved in recombination
A9255_RS11790	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
A9255_RS11800	COG3525	Glycosyl hydrolase, family 20, catalytic domain
A9255_RS11805	COG0848	biopolymer transport protein
A9255_RS11825	COG1979	alcohol dehydrogenase
A9255_RS11830	COG0656	L-ascorbic acid biosynthetic process
A9255_RS11840	COG3726	membrane protein affecting hemolysin expression
A9255_RS11845	COG0560	Phosphoserine phosphatase
A9255_RS11850	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
A9255_RS11860	COG1126	abc transporter atp-binding protein
A9255_RS11865	COG0488	(ABC) transporter
A9255_RS11870	COG0741	lytic transglycosylase activity
A9255_RS11875	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
A9255_RS11880	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
A9255_RS11885	COG0406	alpha-ribazole phosphatase activity
A9255_RS11890	COG3708	Transcriptional regulator
A9255_RS11890	COG2207	Transcriptional regulator
A9255_RS11895	COG3045	CreA protein
A9255_RS11900	COG0745	RESPONSE REGULATOR receiver
A9255_RS11910	COG0083	homoserine kinase activity
A9255_RS11920	COG1278	Cold shock
A9255_RS11925	COG3022	response to hydroperoxide
A9255_RS11930	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A9255_RS11935	COG0521	Mo-molybdopterin cofactor biosynthetic process
A9255_RS11940	COG2723	6-phospho-beta-galactosidase activity
A9255_RS11975	COG1960	acyl-CoA dehydrogenase activity
A9255_RS11990	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
A9255_RS11995	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A9255_RS12005	COG1584	GPR1 FUN34 yaaH family protein
A9255_RS12010	COG0443	Heat shock 70 kDa protein
A9255_RS12015	COG0484	heat shock protein binding
A9255_RS12030	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A9255_RS12035	COG0583	DNA-binding transcription factor activity
A9255_RS12040	COG0268	Binds directly to 16S ribosomal RNA
A9255_RS12045	COG0196	riboflavin kinase activity
A9255_RS12050	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A9255_RS12055	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
A9255_RS12060	COG1047	Peptidyl-prolyl cis-trans
A9255_RS12065	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
A9255_RS12085	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
A9255_RS12090	COG0505	Belongs to the CarA family
A9255_RS12095	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A9255_RS12100	COG0582	viral genome integration into host DNA
A9255_RS12115	COG3539	Fimbrial protein
A9255_RS12120	COG3121	Chaperone
A9255_RS12125	COG3188	usher protein
A9255_RS12130	COG3539	Fimbrial protein
A9255_RS12135	COG0813	purine-nucleoside phosphorylase activity
A9255_RS12140	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
A9255_RS12145	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
A9255_RS12150	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
A9255_RS12155	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A9255_RS12160	COG0084	hydrolase, TatD family'
A9255_RS12165	COG4667	esterase of the alpha-beta hydrolase superfamily
A9255_RS12170	COG2823	Periplasmic or secreted lipoprotein
A9255_RS12175	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
A9255_RS12180	COG0456	acetyltransferase
A9255_RS12185	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
A9255_RS12190	COG2813	Specifically methylates the guanine in position
A9255_RS12215	COG1012	belongs to the aldehyde dehydrogenase family
A9255_RS12225	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A9255_RS12240	COG3423	Transcriptional regulator
A9255_RS12245	COG2076	Multidrug Resistance protein
A9255_RS12250	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A9255_RS12255	COG1509	lysine 2,3-aminomutase activity
A9255_RS12265	COG0459	protein refolding
A9255_RS12280	COG1027	Aspartate ammonia-lyase
A9255_RS12285	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
A9255_RS12290	COG4232	protein-disulfide reductase activity
A9255_RS12295	COG1309	transcriptional regulator
A9255_RS12305	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
A9255_RS12340	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
A9255_RS12405	COG4221	oxidoreductase activity
A9255_RS12415	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
A9255_RS12420	COG0732	type I restriction modification DNA specificity domain
A9255_RS12425	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
A9255_RS12470	COG3501	Rhs element vgr protein
A9255_RS12480	COG4104	PAAR repeat-containing protein
A9255_RS12480	COG3209	COG3209 Rhs family protein
A9255_RS12560	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A9255_RS12560	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
A9255_RS12590	COG3423	Transcriptional regulator
A9255_RS12630	COG0431	NADPH-dependent FMN reductase
A9255_RS12640	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
A9255_RS12685	COG0582	viral genome integration into host DNA
A9255_RS12720	COG3501	Rhs element vgr protein
A9255_RS12730	COG3423	Transcriptional regulator
A9255_RS12745	COG3501	Rhs element vgr protein
A9255_RS12785	COG0477	Major facilitator Superfamily
A9255_RS12800	COG2382	esterase
A9255_RS12810	COG1169	isochorismate synthase
A9255_RS12815	COG1021	2,3-dihydroxybenzoate-AMP ligase
A9255_RS12820	COG3433	isochorismatase activity
A9255_RS12820	COG1535	isochorismatase
A9255_RS12825	COG1028	Short-chain dehydrogenase reductase Sdr
A9255_RS12830	COG2862	Uncharacterized protein family, UPF0114
A9255_RS12845	COG1358	cellular component organization or biogenesis
A9255_RS12885	COG0582	viral genome integration into host DNA
A9255_RS12890	COG3033	Beta-eliminating lyase
A9255_RS12910	COG3853	Toxic anion resistance protein (TelA)
A9255_RS12925	COG2992	FlgJ-related protein
A9255_RS12945	COG2610	gluconate transmembrane transporter activity
A9255_RS12950	COG3265	gluconokinase activity
A9255_RS12955	COG1609	Transcriptional regulator
A9255_RS12960	COG1609	Transcriptional regulator
A9255_RS12965	COG1486	melibiose metabolic process
A9255_RS12970	COG1447	Phosphotransferase system cellobiose-specific component IIA
A9255_RS12975	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A9255_RS13010	COG1203	CRISPR-associated helicase, Cas3
A9255_RS13020	COG0477	Major facilitator Superfamily
A9255_RS13060	COG0300	oxidoreductase activity
A9255_RS13065	COG0300	oxidoreductase activity
A9255_RS13070	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A9255_RS13080	COG1309	transcriptional regulator
A9255_RS13110	COG0693	protein deglycase activity
A9255_RS13130	COG0179	Fumarylacetoacetate (FAA) hydrolase
A9255_RS13175	COG0488	(ABC) transporter
A9255_RS13190	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
A9255_RS13195	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A9255_RS13215	COG2873	o-acetylhomoserine
A9255_RS13240	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A9255_RS13245	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A9255_RS13265	COG1177	transmembrane transport
A9255_RS13275	COG3842	ATPase activity
A9255_RS13285	COG0583	DNA-binding transcription factor activity
A9255_RS13290	COG1301	dicarboxylic acid transport
A9255_RS13310	COG0582	viral genome integration into host DNA
A9255_RS13320	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A9255_RS13335	COG0795	lipopolysaccharide-transporting ATPase activity
A9255_RS13340	COG0795	lipopolysaccharide-transporting ATPase activity
A9255_RS13345	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A9255_RS13350	COG2927	DNA polymerase III (CHI subunit)
A9255_RS13355	COG0525	valine-tRNA ligase activity
A9255_RS13375	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A9255_RS13385	COG0765	amino acid transport
A9255_RS13390	COG1126	abc transporter atp-binding protein
A9255_RS13395	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A9255_RS13410	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A9255_RS13415	COG1012	belongs to the aldehyde dehydrogenase family
A9255_RS13420	COG4638	Rieske (2fe-2S)
A9255_RS13425	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A9255_RS13430	COG0473	3-isopropylmalate dehydrogenase activity
A9255_RS13435	COG0583	DNA-binding transcription factor activity
A9255_RS13440	COG0456	acetyltransferase
A9255_RS13445	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
A9255_RS13450	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A9255_RS13470	COG3541	Predicted nucleotidyltransferase
A9255_RS13475	COG1690	Belongs to the RtcB family
A9255_RS13485	COG4650	regulator
A9255_RS13490	COG1234	tRNA 3'-trailer cleavage
A9255_RS13500	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A9255_RS13505	COG0540	Belongs to the ATCase OTCase family
A9255_RS13530	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
A9255_RS13535	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
A9255_RS13550	COG0602	queuosine metabolic process
A9255_RS13555	COG3787	Belongs to the UPF0306 family
A9255_RS13565	COG3153	acetyltransferase
A9255_RS13570	COG3154	lipid carrier protein
A9255_RS13585	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A9255_RS13590	COG0582	viral genome integration into host DNA
A9255_RS13600	COG3275	phosphorelay sensor kinase activity
A9255_RS13615	COG0513	Belongs to the DEAD box helicase family
A9255_RS13630	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
A9255_RS13635	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A9255_RS13640	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
A9255_RS13645	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
A9255_RS13650	COG0195	Participates in both transcription termination and antitermination
A9255_RS13655	COG0779	Required for maturation of 30S ribosomal subunits
A9255_RS13670	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A9255_RS13675	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A9255_RS13680	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
A9255_RS13690	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
A9255_RS13695	COG1534	Rna-binding protein
A9255_RS13705	COG2027	D-alanyl-D-alanine carboxypeptidase
A9255_RS13710	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A9255_RS13715	COG0211	Belongs to the bacterial ribosomal protein bL27 family
A9255_RS13720	COG0261	This protein binds to 23S rRNA in the presence of protein L20
A9255_RS13725	COG0142	geranyltranstransferase activity
A9255_RS13740	COG3423	Transcriptional regulator
A9255_RS13745	COG0039	L-malate dehydrogenase activity
A9255_RS13755	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A9255_RS13760	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
A9255_RS13770	COG2105	PFAM AIG2 family protein
A9255_RS13775	COG2911	Protein conserved in bacteria
A9255_RS13785	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A9255_RS13790	COG1253	flavin adenine dinucleotide binding
A9255_RS13800	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
A9255_RS13810	COG0545	Peptidyl-prolyl cis-trans isomerase
A9255_RS13820	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
A9255_RS13825	COG2965	DNA replication, synthesis of RNA primer
A9255_RS13830	COG0360	Binds together with S18 to 16S ribosomal RNA
A9255_RS13835	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A9255_RS13840	COG0557	exoribonuclease II activity
A9255_RS13845	COG1959	2 iron, 2 sulfur cluster binding
A9255_RS13850	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
A9255_RS13855	COG0330	HflC and HflK could
A9255_RS13860	COG0330	HflC and HflK could
A9255_RS13865	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A9255_RS13870	COG1923	regulation of RNA biosynthetic process
A9255_RS13875	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
A9255_RS13880	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
A9255_RS13890	COG0802	atpase or kinase
A9255_RS13895	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A9255_RS13900	COG2368	4-hydroxyphenylacetate
A9255_RS13905	COG1960	acyl-CoA dehydrogenase activity
A9255_RS13910	COG3033	Beta-eliminating lyase
A9255_RS13920	COG0477	Major facilitator Superfamily
A9255_RS13925	COG0583	DNA-binding transcription factor activity
A9255_RS13930	COG2368	4-hydroxyphenylacetate
A9255_RS13970	COG2814	Major facilitator Superfamily
A9255_RS13980	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
A9255_RS13985	COG1162	GTPase activity
A9255_RS13990	COG0688	phosphatidylethanolamine metabolic process
A9255_RS13995	COG1511	domain protein
A9255_RS13995	COG3264	Mechanosensitive ion channel
A9255_RS14010	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A9255_RS14045	COG1609	Transcriptional regulator
A9255_RS14050	COG0477	Major facilitator Superfamily
A9255_RS14055	COG0561	phosphatase activity
A9255_RS14060	COG2267	carboxylic ester hydrolase activity
A9255_RS14065	COG0514	ATP-dependent DNA helicase (RecQ)
A9255_RS14075	COG2050	protein possibly involved in aromatic compounds catabolism
A9255_RS14085	COG2962	Rard protein
A9255_RS14090	COG0598	Magnesium transport protein CorA
A9255_RS14095	COG0210	DNA helicase
A9255_RS14100	COG1011	Hydrolase
A9255_RS14110	COG3159	Protein conserved in bacteria
A9255_RS14115	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
A9255_RS14120	COG1965	Belongs to the frataxin family
A9255_RS14130	COG0181	hydroxymethylbilane synthase activity
A9255_RS14140	COG2959	enzyme of heme biosynthesis
A9255_RS14145	COG3071	HemY protein
A9255_RS14175	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
A9255_RS14185	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
A9255_RS14190	COG2244	polysaccharide biosynthetic process
A9255_RS14195	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A9255_RS14200	COG0456	acetyltransferase
A9255_RS14205	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
A9255_RS14210	COG1088	dTDP-glucose 4,6-dehydratase activity
A9255_RS14215	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
A9255_RS14220	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
A9255_RS14225	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
A9255_RS14230	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A9255_RS14235	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
A9255_RS14240	COG3118	belongs to the thioredoxin family
A9255_RS14245	COG0513	Belongs to the DEAD box helicase family
A9255_RS14250	COG0248	Ppx GppA phosphatase
A9255_RS14265	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
A9255_RS14270	COG0583	DNA-binding transcription factor activity
A9255_RS14280	COG1566	PFAM secretion protein HlyD family protein
A9255_RS14285	COG2814	Major facilitator Superfamily
A9255_RS14295	COG0129	dihydroxy-acid dehydratase activity
A9255_RS14305	COG3978	acetolactate synthase activity
A9255_RS14315	COG0606	chelatase, subunit chli
A9255_RS14320	COG3085	chromosome segregation
A9255_RS14325	COG0583	DNA-binding transcription factor activity
A9255_RS14360	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
A9255_RS14370	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A9255_RS14375	COG0009	L-threonylcarbamoyladenylate synthase
A9255_RS14380	COG0551	DNA topoisomerase type I activity
A9255_RS14385	COG0758	DNA mediated transformation
A9255_RS14390	COG0242	peptide deformylase activity
A9255_RS14395	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A9255_RS14400	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A9255_RS14400	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A9255_RS14405	COG0569	domain protein
A9255_RS14410	COG3036	rescue of stalled ribosome
A9255_RS14415	COG0789	Transcriptional regulator
A9255_RS14420	COG0203	ribosomal protein L17
A9255_RS14425	COG0202	RNA polymerase activity
A9255_RS14430	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
A9255_RS14440	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
A9255_RS14445	COG0257	Belongs to the bacterial ribosomal protein bL36 family
A9255_RS14450	COG0201	protein transport
A9255_RS14455	COG0200	Binds to the 23S rRNA
A9255_RS14460	COG1841	ribosomal large subunit assembly
A9255_RS14465	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
A9255_RS14470	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
A9255_RS14475	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
A9255_RS14480	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
A9255_RS14485	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
A9255_RS14490	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
A9255_RS14495	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
A9255_RS14500	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
A9255_RS14505	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
A9255_RS14515	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
A9255_RS14530	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
A9255_RS14535	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
A9255_RS14545	COG0088	Forms part of the polypeptide exit tunnel
A9255_RS14550	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
A9255_RS14555	COG0051	transcription antitermination factor activity, RNA binding
A9255_RS14565	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A9255_RS14590	COG1072	(Pantothenic acid kinase))
A9255_RS14600	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A9255_RS14635	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
A9255_RS14640	COG4206	TonB-dependent receptor
A9255_RS14645	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A9255_RS14660	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A9255_RS14670	COG0165	Argininosuccinate lyase
A9255_RS14675	COG0137	argininosuccinate synthase activity
A9255_RS14680	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A9255_RS14685	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
A9255_RS14690	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A9255_RS14705	COG0477	Major facilitator Superfamily
A9255_RS14710	COG0583	DNA-binding transcription factor activity
A9255_RS14715	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
A9255_RS14720	COG0527	aspartate kinase activity
A9255_RS14720	COG0460	homoserine dehydrogenase
A9255_RS14725	COG0626	cystathionine gamma-synthase activity
A9255_RS14730	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
A9255_RS14740	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A9255_RS14745	COG1609	Transcriptional regulator
A9255_RS14750	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A9255_RS14755	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
A9255_RS14760	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
A9255_RS14765	COG1575	Belongs to the MenA family. Type 1 subfamily
A9255_RS14770	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
A9255_RS14775	COG3074	FtsZ-dependent cytokinesis
A9255_RS14785	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
A9255_RS14790	COG2814	Major facilitator Superfamily
A9255_RS14800	COG3152	Membrane
A9255_RS14810	COG0149	triose-phosphate isomerase activity
A9255_RS14815	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
A9255_RS14820	COG0205	6-phosphofructokinase activity
A9255_RS14830	COG4589	Belongs to the CDS family
A9255_RS14840	COG3678	ATP-independent chaperone mediated protein folding
A9255_RS14845	COG0745	RESPONSE REGULATOR receiver
A9255_RS14850	COG2205	protein histidine kinase activity
A9255_RS14880	COG0463	Glycosyl transferase, family 2
A9255_RS14900	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A9255_RS14905	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
A9255_RS14910	COG1045	serine acetyltransferase
A9255_RS14915	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
A9255_RS14920	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
A9255_RS14925	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A9255_RS14930	COG4942	peptidase
A9255_RS14935	COG2861	carbohydrate metabolic process
A9255_RS14940	COG1063	alcohol dehydrogenase
A9255_RS14945	COG0156	8-amino-7-oxononanoate synthase activity
A9255_RS14950	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A9255_RS14980	COG0859	PFAM glycosyl transferase family 9
A9255_RS14990	COG0438	transferase activity, transferring glycosyl groups
A9255_RS14995	COG1519	Transferase
A9255_RS15005	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
A9255_RS15010	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A9255_RS15035	COG0438	transferase activity, transferring glycosyl groups
A9255_RS15040	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A9255_RS15050	COG2003	Belongs to the UPF0758 family
A9255_RS15055	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A9255_RS15060	COG0756	dUTP diphosphatase activity
A9255_RS15065	COG1309	transcriptional regulator
A9255_RS15070	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
A9255_RS15075	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
A9255_RS15080	COG1561	YicC-like family, N-terminal region
A9255_RS15105	COG3645	SOS response
A9255_RS15125	COG1368	sulfuric ester hydrolase activity
A9255_RS15130	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
A9255_RS15175	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
A9255_RS15180	COG0706	membrane insertase activity
A9255_RS15185	COG0594	ribonuclease P activity
A9255_RS15190	COG0230	Belongs to the bacterial ribosomal protein bL34 family
A9255_RS15200	COG0592	DNA-directed DNA polymerase activity
A9255_RS15205	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A9255_RS15210	COG0187	DNA topoisomerase II activity
A9255_RS15220	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A9255_RS15225	COG0254	rRNA binding
A9255_RS15240	COG2255	four-way junction helicase activity
A9255_RS15305	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A9255_RS15315	COG0355	proton-transporting ATP synthase activity, rotational mechanism
A9255_RS15320	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
A9255_RS15325	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
A9255_RS15330	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
A9255_RS15335	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A9255_RS15340	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A9255_RS15350	COG0356	it plays a direct role in the translocation of protons across the membrane
A9255_RS15355	COG3312	ion transport
A9255_RS15360	COG0357	Ribosomal RNA small subunit methyltransferase G
A9255_RS15365	COG0445	tRNA wobble uridine modification
A9255_RS15370	COG0716	FMN binding
A9255_RS15375	COG1522	sequence-specific DNA binding
A9255_RS15380	COG2502	aspartate--ammonia ligase
A9255_RS15385	COG2425	protein containing a von Willebrand factor type A (vWA) domain
A9255_RS15390	COG0714	Associated with various cellular activities
A9255_RS15395	COG1869	D-ribose catabolic process
A9255_RS15400	COG1129	ABC transporter
A9255_RS15405	COG1172	Belongs to the binding-protein-dependent transport system permease family
A9255_RS15410	COG1879	ABC-type sugar transport system periplasmic component
A9255_RS15415	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A9255_RS15420	COG1609	Transcriptional regulator
A9255_RS15425	COG0477	Major facilitator Superfamily
A9255_RS15455	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A9255_RS15460	COG3162	membrane
A9255_RS15465	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A9255_RS15470	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
A9255_RS15480	COG2258	MOSC domain
A9255_RS15485	COG3774	pathogenesis
A9255_RS15490	COG0180	Tryptophanyl-tRNA synthetase
A9255_RS15495	COG0546	phosphoglycolate phosphatase activity
A9255_RS15500	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A9255_RS15515	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
A9255_RS15520	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
A9255_RS15525	COG4796	Type ii and iii secretion system protein
A9255_RS15545	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
A9255_RS15555	COG0494	nUDIX hydrolase
A9255_RS15565	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
A9255_RS15570	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
A9255_RS15575	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
A9255_RS15610	COG2081	HI0933 family
A9255_RS15615	COG0306	phosphate transporter
A9255_RS15625	COG0589	response to stress
A9255_RS15640	COG0742	ribosomal rna small subunit methyltransferase
A9255_RS15670	COG0366	Alpha amylase catalytic
A9255_RS15675	COG1263	PTS System
A9255_RS15675	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A9255_RS15715	COG3327	negative regulation of DNA-templated transcription, initiation
A9255_RS15720	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
A9255_RS15725	COG0183	Belongs to the thiolase family
A9255_RS15730	COG2050	protein possibly involved in aromatic compounds catabolism
A9255_RS15735	COG1250	3-hydroxyacyl-CoA dehydrogenase
A9255_RS15740	COG1024	Enoyl-CoA hydratase
A9255_RS15745	COG1024	Enoyl-CoA hydratase
A9255_RS15750	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A9255_RS15755	COG2151	metal-sulfur cluster biosynthetic enzyme
A9255_RS15760	COG3396	Phenylacetate-CoA oxygenase
A9255_RS15765	COG3460	Phenylacetate-CoA oxygenase
A9255_RS15770	COG3396	Phenylacetate-CoA oxygenase
A9255_RS15775	COG1012	belongs to the aldehyde dehydrogenase family
A9255_RS15775	COG2030	dehydratase
A9255_RS15785	COG0626	cystathionine gamma-synthase activity
A9255_RS15800	COG1735	metal-dependent hydrolase with the TIM-barrel fold
A9255_RS15805	COG3457	Alanine racemase
A9255_RS15815	COG2188	Transcriptional regulator
A9255_RS15840	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
A9255_RS15845	COG1349	DNA-binding transcription factor activity
A9255_RS15850	COG0705	Rhomboid family
A9255_RS15855	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A9255_RS15860	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
A9255_RS15860	COG0316	Belongs to the HesB IscA family
A9255_RS15870	COG0596	Alpha beta hydrolase
A9255_RS15895	COG1918	ferrous iron import across plasma membrane
A9255_RS15905	COG2183	response to ionizing radiation
A9255_RS15910	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A9255_RS15925	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
A9255_RS15930	COG0573	inorganic phosphate transmembrane transporter activity
A9255_RS15935	COG0581	inorganic phosphate transmembrane transporter activity
A9255_RS15940	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A9255_RS15945	COG0704	Plays a role in the regulation of phosphate uptake
A9255_RS15950	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A9255_RS15955	COG0765	amino acid transport
A9255_RS15960	COG0765	amino acid transport
A9255_RS15980	COG2252	PERMEase
A9255_RS16055	COG1011	Hydrolase
A9255_RS16060	COG1490	D-aminoacyl-tRNA deacylase activity
A9255_RS16065	COG0456	acetyltransferase
A9255_RS16070	COG2982	Protein involved in outer membrane biogenesis
A9255_RS16075	COG2233	PERMEase
A9255_RS16080	COG0786	glutamate:sodium symporter activity
A9255_RS16085	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A9255_RS16090	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A9255_RS16095	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A9255_RS16105	COG0194	GDP metabolic process
A9255_RS16110	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A9255_RS16115	COG2860	membrane
A9255_RS16120	COG0823	Involved in the tonB-independent uptake of proteins
A9255_RS16125	COG5645	(Lipo)protein
A9255_RS16130	COG3977	Valine--pyruvate aminotransferase
A9255_RS16135	COG2818	Glycosylase
A9255_RS16140	COG0752	glycyl-tRNA synthetase alpha subunit
A9255_RS16145	COG0751	glycine-tRNA ligase activity
A9255_RS16155	COG0747	negative chemotaxis
A9255_RS16160	COG0601	transmembrane transport
A9255_RS16165	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A9255_RS16170	COG0444	Belongs to the ABC transporter superfamily
A9255_RS16175	COG4608	Belongs to the ABC transporter superfamily
A9255_RS16180	COG2199	diguanylate cyclase activity
A9255_RS16180	COG2200	EAL domain
A9255_RS16185	COG0612	Peptidase, M16
A9255_RS16200	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A9255_RS16200	COG2169	Transcriptional regulator
A9255_RS16210	COG1942	4-Oxalocrotonate Tautomerase
A9255_RS16215	COG1295	ribonuclease BN
A9255_RS16310	COG3501	Rhs element vgr protein
A9255_RS16320	COG4104	PAAR repeat-containing protein
A9255_RS16320	COG3209	COG3209 Rhs family protein
A9255_RS16345	COG3209	COG3209 Rhs family protein
A9255_RS16345	COG4104	PAAR repeat-containing protein
A9255_RS16385	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
A9255_RS16390	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A9255_RS16405	COG1396	sequence-specific DNA binding
A9255_RS16410	COG1070	Carbohydrate kinase
A9255_RS16415	COG2390	Transcriptional regulator
A9255_RS16430	COG1172	Belongs to the binding-protein-dependent transport system permease family
A9255_RS16440	COG1830	Aldolase
A9255_RS16445	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
A9255_RS16455	COG0076	glutamate decarboxylase activity
A9255_RS16465	COG1763	Mo-molybdopterin cofactor biosynthetic process
A9255_RS16470	COG0746	molybdenum cofactor guanylyltransferase activity
A9255_RS16475	COG3084	Protein conserved in bacteria
A9255_RS16480	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
A9255_RS16490	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A9255_RS16490	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A9255_RS16495	COG0218	Necessary for normal cell division and for the maintenance of normal septation
A9255_RS16520	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A9255_RS16530	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A9255_RS16535	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A9255_RS16540	COG3954	Phosphoribulokinase
A9255_RS16555	COG1280	lysine exporter protein (LysE YggA)
A9255_RS16560	COG1263	PTS System
A9255_RS16560	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A9255_RS16565	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
A9255_RS16570	COG1662	PFAM IS1 transposase
A9255_RS16570	COG3677	Transposase
A9255_RS16575	COG0583	DNA-binding transcription factor activity
A9255_RS16580	COG0488	(ABC) transporter
A9255_RS16585	COG2249	NAD(P)H dehydrogenase (quinone) activity
A9255_RS16595	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
A9255_RS16600	COG1047	Peptidyl-prolyl cis-trans
A9255_RS16605	COG2900	Belongs to the SlyX family
A9255_RS16610	COG0545	Peptidyl-prolyl cis-trans isomerase
A9255_RS16615	COG2964	Protein conserved in bacteria
A9255_RS16620	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
A9255_RS16625	COG2923	Belongs to the DsrF TusC family
A9255_RS16630	COG2168	tRNA wobble position uridine thiolation
A9255_RS16635	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
A9255_RS16640	COG0049	tRNA binding
A9255_RS16645	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A9255_RS16660	COG0250	Participates in transcription elongation, termination and antitermination
A9255_RS16665	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
A9255_RS16670	COG0081	regulation of translation
A9255_RS16675	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
A9255_RS16680	COG0222	ribosome binding
A9255_RS16685	COG0085	RNA polymerase activity
A9255_RS16690	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A9255_RS16700	COG4580	involved in the transport of maltose and maltodextrins
A9255_RS16705	COG3842	ATPase activity
A9255_RS16710	COG2182	Extracellular solute-binding protein
A9255_RS16715	COG1175	transmembrane transport
A9255_RS16720	COG3833	ABC-type maltose transport systems, permease component
A9255_RS16725	COG1640	4-alpha-glucanotransferase
A9255_RS16730	COG0058	SHG alpha-glucan phosphorylase activity
A9255_RS16735	COG2909	trisaccharide binding
A9255_RS16740	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A9255_RS16745	COG1063	alcohol dehydrogenase
A9255_RS16750	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A9255_RS16755	COG2223	nitrite transmembrane transporter activity
A9255_RS16770	COG2022	thiamine diphosphate biosynthetic process
A9255_RS16775	COG2104	thiamine diphosphate biosynthetic process
A9255_RS16780	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A9255_RS16785	COG0352	thiamine-phosphate diphosphorylase activity
A9255_RS16790	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
A9255_RS16810	COG2816	NAD+ diphosphatase activity
A9255_RS16815	COG0339	signal peptide processing
A9255_RS16820	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
A9255_RS16825	COG1515	deoxyribonuclease V activity
A9255_RS16845	COG0151	Belongs to the GarS family
A9255_RS16850	COG0138	bifunctional purine biosynthesis protein purh
A9255_RS16890	COG1914	H( )-stimulated, divalent metal cation uptake system
A9255_RS16895	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
A9255_RS16905	COG4770	biotin carboxylase activity
A9255_RS16910	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
A9255_RS16915	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
A9255_RS16920	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A9255_RS16925	COG1053	succinate dehydrogenase
A9255_RS16935	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
A9255_RS16940	COG0584	glycerophosphoryl diester phosphodiesterase
A9255_RS16945	COG2271	Major facilitator Superfamily
A9255_RS16965	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
A9255_RS16985	COG3714	YhhN family
A9255_RS16990	COG3776	membrane
A9255_RS16995	COG0742	ribosomal rna small subunit methyltransferase
A9255_RS17000	COG0552	protein localization to endoplasmic reticulum
A9255_RS17000	COG0552	protein localization to endoplasmic reticulum
A9255_RS17005	COG2884	Cell division ATP-binding protein ftsE
A9255_RS17010	COG2177	Part of the ABC transporter FtsEX involved in
A9255_RS17015	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A9255_RS17020	COG2610	gluconate transmembrane transporter activity
A9255_RS17025	COG1929	Belongs to the glycerate kinase type-1 family
A9255_RS17030	COG2814	Major facilitator Superfamily
A9255_RS17035	COG1846	Transcriptional regulator
A9255_RS17070	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
A9255_RS17075	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A9255_RS17085	COG2264	protein methyltransferase activity
A9255_RS17090	COG4145	pantothenate transmembrane transporter activity
A9255_RS17095	COG3924	membrane
A9255_RS17100	COG2373	Large extracellular alpha-helical protein
A9255_RS17100	COG4932	domain protein
A9255_RS17100	COG1388	LysM domain
A9255_RS17115	COG0439	Biotin carboxylase
A9255_RS17120	COG0511	ligase activity, forming carbon-carbon bonds
A9255_RS17125	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
A9255_RS17130	COG0604	alcohol dehydrogenase
A9255_RS17135	COG1077	Cell shape determining protein MreB Mrl
A9255_RS17145	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
A9255_RS17150	COG0424	maF-like protein
A9255_RS17155	COG1530	ribonuclease E activity
A9255_RS17160	COG3164	Protein of unknown function
A9255_RS17165	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A9255_RS17170	COG0312	modulator of DNA gyrase
A9255_RS17180	COG2732	(Barnase) inhibitor
A9255_RS17200	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A9255_RS17205	COG3028	Belongs to the UPF0307 family
A9255_RS17210	COG0312	modulator of DNA gyrase
A9255_RS17215	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A9255_RS17230	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A9255_RS17235	COG1660	Displays ATPase and GTPase activities
A9255_RS17250	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
A9255_RS17255	COG1137	ATPase activity
A9255_RS17260	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
A9255_RS17265	COG3117	lipopolysaccharide transmembrane transporter activity
A9255_RS17270	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
A9255_RS17275	COG0517	IMP dehydrogenase activity
A9255_RS17275	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
A9255_RS17280	COG0530	calcium, potassium:sodium antiporter activity
A9255_RS17285	COG1127	ABC transporter
A9255_RS17290	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A9255_RS17295	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
A9255_RS17300	COG2854	intermembrane phospholipid transfer
A9255_RS17310	COG5007	Belongs to the BolA IbaG family
A9255_RS17315	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A9255_RS17320	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A9255_RS17325	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A9255_RS17330	COG3105	Protein conserved in bacteria
A9255_RS17335	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
A9255_RS17340	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
A9255_RS17345	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A9255_RS17350	COG0625	glutathione transferase activity
A9255_RS17355	COG2969	positive regulation of protein catabolic process
A9255_RS17365	COG0493	'glutamate synthase
A9255_RS17370	COG0070	glutamate synthase
A9255_RS17370	COG0069	glutamate synthase activity
A9255_RS17370	COG0067	glutamate synthase
A9255_RS17375	COG2198	Histidine kinase
A9255_RS17375	COG5002	protein histidine kinase activity
A9255_RS17375	COG0784	Response regulator, receiver
A9255_RS17380	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
A9255_RS17385	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A9255_RS17390	COG2823	Periplasmic or secreted lipoprotein
A9255_RS17395	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
A9255_RS17400	COG0792	nuclease activity
A9255_RS17410	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
A9255_RS17420	COG1741	Belongs to the pirin family
A9255_RS17425	COG0583	DNA-binding transcription factor activity
A9255_RS17430	COG2259	Doxx family
A9255_RS17440	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
A9255_RS17445	COG4575	ribosome binding
A9255_RS17450	COG0586	Pfam SNARE associated Golgi protein
A9255_RS17465	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
A9255_RS17475	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
A9255_RS17480	COG0446	pyridine nucleotide-disulphide oxidoreductase
A9255_RS17480	COG1902	pentaerythritol trinitrate reductase activity
A9255_RS17490	COG2990	Protein conserved in bacteria
A9255_RS17500	COG0477	Major facilitator Superfamily
A9255_RS17515	COG1028	Short-chain dehydrogenase reductase Sdr
A9255_RS17525	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A9255_RS17570	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A9255_RS17575	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A9255_RS17620	COG4974	Belongs to the 'phage' integrase family
A9255_RS17680	COG4695	Portal protein
A9255_RS17790	COG1724	mRNA binding
A9255_RS17795	COG1598	PFAM Uncharacterised protein family UPF0150
A9255_RS17815	COG0358	DNA primase activity
A9255_RS17820	COG0828	Belongs to the bacterial ribosomal protein bS21 family
A9255_RS17825	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
A9255_RS17840	COG3133	Outer membrane lipoprotein
A9255_RS17850	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
A9255_RS17855	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
A9255_RS17860	COG0617	tRNA 3'-terminal CCA addition
A9255_RS17865	COG4991	sh3 domain protein
A9255_RS17870	COG3025	triphosphatase activity
A9255_RS17875	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
A9255_RS17880	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
A9255_RS17880	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
A9255_RS17890	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A9255_RS17895	COG3384	dioxygenase
A9255_RS17900	COG0754	glutathionylspermidine amidase activity
A9255_RS17905	COG5463	Belongs to the UPF0441 family
A9255_RS17910	COG1538	Outer membrane efflux protein
A9255_RS17915	COG0494	nUDIX hydrolase
A9255_RS17920	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
A9255_RS17925	COG3150	esterase
A9255_RS17930	COG0187	DNA topoisomerase II activity
A9255_RS17935	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A9255_RS17940	COG0204	Acyl-transferase
A9255_RS17945	COG2132	Multicopper oxidase
A9255_RS17955	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
A9255_RS17960	COG2967	ApaG domain
A9255_RS17965	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A9255_RS17970	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
A9255_RS17975	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A9255_RS17980	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
A9255_RS17985	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
A9255_RS17990	COG0564	pseudouridine synthase activity
A9255_RS17995	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A9255_RS18000	COG0417	DNA replication proofreading
A9255_RS18020	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
A9255_RS18025	COG1178	ABC-type Fe3 transport system permease component
A9255_RS18030	COG4143	(ABC) transporter
A9255_RS18035	COG0494	nUDIX hydrolase
A9255_RS18045	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
A9255_RS18050	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
A9255_RS18060	COG4795	General secretion pathway protein
A9255_RS18075	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
A9255_RS18080	COG1025	Belongs to the peptidase M16 family
A9255_RS18085	COG1074	ATP-dependent DNA helicase activity
A9255_RS18090	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A9255_RS18100	COG0860	N-Acetylmuramoyl-L-alanine amidase
A9255_RS18120	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
A9255_RS18125	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
A9255_RS18130	COG2166	iron-sulfur cluster assembly
A9255_RS18140	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A9255_RS18145	COG0583	DNA-binding transcription factor activity
A9255_RS18150	COG2363	Small membrane protein
A9255_RS18190	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A9255_RS18195	COG1611	Belongs to the LOG family
A9255_RS18200	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
A9255_RS18200	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
A9255_RS18215	COG3098	single-species biofilm formation
A9255_RS18220	COG0564	pseudouridine synthase activity
A9255_RS18255	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
A9255_RS18265	COG0052	Belongs to the universal ribosomal protein uS2 family
A9255_RS18270	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
A9255_RS18275	COG0528	UMP kinase activity
A9255_RS18280	COG0233	cytoplasmic translational termination
A9255_RS18285	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
A9255_RS18290	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A9255_RS18295	COG0575	Belongs to the CDS family
A9255_RS18300	COG0750	zinc metalloprotease
A9255_RS18315	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A9255_RS18320	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A9255_RS18325	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A9255_RS18330	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A9255_RS18335	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A9255_RS18345	COG0825	malonyl-CoA metabolic process
A9255_RS18355	COG0037	tRNA processing
A9255_RS18370	COG4568	rho-dependent transcription termination
A9255_RS18375	COG3015	lipoprotein NlpE involved in copper resistance
A9255_RS18380	COG0442	prolyl-tRNA aminoacylation
A9255_RS18385	COG1720	tRNA m6t6A37 methyltransferase activity
A9255_RS18395	COG1464	Belongs to the NlpA lipoprotein family
A9255_RS18405	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A9255_RS18410	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
A9255_RS18440	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
A9255_RS18445	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
A9255_RS18450	COG2224	Isocitrate lyase
A9255_RS18455	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
A9255_RS18475	COG1414	Transcriptional regulator
A9255_RS18485	COG0527	aspartate kinase activity
A9255_RS18490	COG0166	Belongs to the GPI family
A9255_RS18495	COG3161	chorismate lyase activity
A9255_RS18500	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
A9255_RS18505	COG2937	Belongs to the GPAT DAPAT family
A9255_RS18510	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
A9255_RS18520	COG0735	belongs to the Fur family
A9255_RS18540	COG2814	Major facilitator Superfamily
A9255_RS18570	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
A9255_RS18575	COG5532	Uncharacterized conserved protein (DUF2303)
A9255_RS18610	COG4725	Belongs to the MT-A70-like family
A9255_RS18620	COG1403	HNH endonuclease
A9255_RS18700	COG4626	Terminase
A9255_RS18700	COG1802	Transcriptional regulator
A9255_RS18810	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A9255_RS18815	COG0604	alcohol dehydrogenase
A9255_RS18820	COG0582	viral genome integration into host DNA
A9255_RS18855	COG1802	Transcriptional regulator
A9255_RS18855	COG4626	Terminase
A9255_RS18865	COG3423	Transcriptional regulator
A9255_RS18880	COG1448	Aminotransferase
A9255_RS18900	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A9255_RS18990	COG2252	PERMEase
A9255_RS18995	COG0025	NhaP-type Na H and K H
A9255_RS19005	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
A9255_RS19015	COG3395	kinase activity
A9255_RS19020	COG3622	Belongs to the hyi family
A9255_RS19025	COG1349	DNA-binding transcription factor activity
A9255_RS19030	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A9255_RS19035	COG2610	gluconate transmembrane transporter activity
A9255_RS19040	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
A9255_RS19050	COG0586	Pfam SNARE associated Golgi protein
A9255_RS19055	COG1322	Protein conserved in bacteria
A9255_RS19060	COG2226	methyltransferase
A9255_RS19065	COG3165	ubiquinone biosynthetic process from chorismate
A9255_RS19070	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
A9255_RS19075	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A9255_RS19080	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A9255_RS19085	COG0805	protein transport
A9255_RS19100	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
A9255_RS19110	COG0183	Belongs to the thiolase family
A9255_RS19115	COG1024	Enoyl-CoA hydratase
A9255_RS19115	COG1250	3-hydroxyacyl-CoA dehydrogenase
A9255_RS19120	COG0006	proline dipeptidase activity
A9255_RS19125	COG1739	Uncharacterized protein family UPF0029
A9255_RS19135	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
A9255_RS19170	COG3021	interspecies interaction between organisms
A9255_RS19180	COG0602	queuosine metabolic process
A9255_RS19185	COG0720	synthase
A9255_RS19190	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
A9255_RS19195	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A9255_RS19200	COG0175	sulfate reduction
A9255_RS19245	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A9255_RS19250	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A9255_RS19255	COG1648	precorrin-2 dehydrogenase activity
A9255_RS19255	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A9255_RS19260	COG0175	sulfate reduction
A9255_RS19265	COG2895	sulfate adenylyltransferase (ATP) activity
A9255_RS19270	COG0529	Catalyzes the synthesis of activated sulfate
A9255_RS19280	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
A9255_RS19285	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
A9255_RS19290	COG0585	pseudouridine synthase activity
A9255_RS19295	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
A9255_RS19300	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
A9255_RS19305	COG4942	peptidase
A9255_RS19305	COG1388	LysM domain
A9255_RS19320	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
A9255_RS19340	COG0024	Methionine aminopeptidase
A9255_RS19345	COG2194	sulfuric ester hydrolase activity
A9255_RS19350	COG1966	Carbon starvation protein
A9255_RS19355	COG2879	small protein
A9255_RS19360	COG0523	cobalamin synthesis protein
A9255_RS19365	COG0582	viral genome integration into host DNA
A9255_RS19370	COG0814	amino acid
A9255_RS19395	COG0534	Mate efflux family protein
A9255_RS19400	COG3842	ATPase activity
A9255_RS19410	COG1840	ABC-type Fe3 transport system, periplasmic component
A9255_RS19415	COG2271	Major facilitator Superfamily
A9255_RS19445	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
A9255_RS19465	COG0288	reversible hydration of carbon dioxide
A9255_RS19470	COG1131	(ABC) transporter
A9255_RS19475	COG0842	Transport permease protein
A9255_RS19480	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A9255_RS19490	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
A9255_RS19495	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
A9255_RS19500	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
A9255_RS19510	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A9255_RS19520	COG1489	DNA binding
A9255_RS19525	COG1643	Atp-dependent helicase
A9255_RS19530	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A9255_RS19540	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
A9255_RS19545	COG0316	Belongs to the HesB IscA family
A9255_RS19560	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A9255_RS19565	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A9255_RS19580	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A9255_RS19585	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A9255_RS19590	COG3956	TIGRFAM MazG family protein
A9255_RS19595	COG0504	CTP synthase activity
A9255_RS19600	COG0148	phosphopyruvate hydratase activity
A9255_RS19605	COG0471	metal ion transport
A9255_RS19610	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
A9255_RS19615	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
A9255_RS19620	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A9255_RS19625	COG4651	solute:proton antiporter activity
A9255_RS19625	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A9255_RS19635	COG0737	Belongs to the 5'-nucleotidase family
A9255_RS19645	COG3735	TraB family
A9255_RS19650	COG2217	Heavy metal translocating P-type atpase
A9255_RS19660	COG1585	Membrane protein implicated in regulation of membrane protease activity
A9255_RS19665	COG0330	HflC and HflK could
A9255_RS19670	COG3118	belongs to the thioredoxin family
A9255_RS19675	COG1509	lysine 2,3-aminomutase activity
A9255_RS19680	COG0436	Aminotransferase
A9255_RS19690	COG0604	alcohol dehydrogenase
A9255_RS19690	COG3321	synthase
A9255_RS19730	COG2755	lipolytic protein G-D-S-L family
A9255_RS19735	COG4181	ATPase activity
A9255_RS19740	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
A9255_RS19755	COG0307	riboflavin synthase, alpha
A9255_RS19760	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
A9255_RS19765	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
A9255_RS19770	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A9255_RS19775	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A9255_RS19780	COG0215	cysteine-tRNA ligase activity
A9255_RS19785	COG2501	S4 domain
A9255_RS19790	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
A9255_RS19900	COG0484	heat shock protein binding
A9255_RS19980	COG0740	serine-type endopeptidase activity
A9255_RS20075	COG2264	protein methyltransferase activity
A9255_RS20105	COG3501	Rhs element vgr protein
A9255_RS20135	COG3423	Transcriptional regulator
A9255_RS20155	COG0582	viral genome integration into host DNA
A9255_RS20180	COG1484	DNA-dependent DNA replication
A9255_RS20185	COG0305	Participates in initiation and elongation during chromosome replication
A9255_RS20240	COG1802	Transcriptional regulator
A9255_RS20240	COG4626	Terminase
A9255_RS20245	COG4695	Portal protein
A9255_RS20340	COG3657	addiction module killer protein
A9255_RS20345	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A9255_RS20380	COG3209	COG3209 Rhs family protein
A9255_RS20395	COG3501	Rhs element vgr protein
A9255_RS20430	COG0583	DNA-binding transcription factor activity
A9255_RS20465	COG0789	Transcriptional regulator
A9255_RS20475	COG0354	folic acid binding
A9255_RS20495	COG1388	LysM domain
A9255_RS20495	COG0741	lytic transglycosylase activity
A9255_RS20500	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A9255_RS20505	COG2226	methyltransferase
A9255_RS20515	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A9255_RS20530	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
A9255_RS20535	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
A9255_RS20540	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A9255_RS20545	COG0126	phosphoglycerate kinase activity
A9255_RS20555	COG3104	oligopeptide transport
A9255_RS20560	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A9255_RS20565	COG2368	4-hydroxyphenylacetate
A9255_RS20585	COG3971	2-oxopent-4-enoate hydratase activity
A9255_RS20600	COG3384	dioxygenase
A9255_RS20605	COG1012	belongs to the aldehyde dehydrogenase family
A9255_RS20615	COG0179	Fumarylacetoacetate (FAA) hydrolase
A9255_RS20620	COG1846	Transcriptional regulator
A9255_RS20635	COG3962	Belongs to the TPP enzyme family
A9255_RS20640	COG0673	inositol 2-dehydrogenase activity
A9255_RS20645	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A9255_RS20650	COG0673	inositol 2-dehydrogenase activity
A9255_RS20655	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A9255_RS20665	COG3718	enzyme involved in inositol metabolism
A9255_RS20670	COG2197	response regulator
A9255_RS20685	COG0346	lactoylglutathione lyase activity
A9255_RS20700	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A9255_RS20715	COG0318	PFAM AMP-dependent synthetase and ligase
A9255_RS20720	COG1028	Short-chain dehydrogenase reductase Sdr
A9255_RS20725	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)