locus-tag	class	description
H8F46_RS00030	COG1203	CRISPR-associated helicase, Cas3
H8F46_RS00060	COG2226	methyltransferase
H8F46_RS00065	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H8F46_RS00070	COG0741	lytic transglycosylase activity
H8F46_RS00070	COG1388	LysM domain
H8F46_RS00075	COG3842	ATPase activity
H8F46_RS00085	COG1177	transmembrane transport
H8F46_RS00100	COG3293	Transposase
H8F46_RS00165	COG3501	Rhs element vgr protein
H8F46_RS00230	COG0346	lactoylglutathione lyase activity
H8F46_RS00235	COG3397	chitin binding
H8F46_RS00255	COG5433	transposase activity
H8F46_RS00275	COG3335	DDE superfamily endonuclease
H8F46_RS00440	COG3335	DDE superfamily endonuclease
H8F46_RS00450	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H8F46_RS00460	COG0028	Belongs to the TPP enzyme family
H8F46_RS00465	COG2814	Major facilitator Superfamily
H8F46_RS00470	COG1028	Short-chain dehydrogenase reductase Sdr
H8F46_RS00480	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
H8F46_RS00490	COG2801	Transposase and inactivated derivatives
H8F46_RS00515	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H8F46_RS00550	COG3657	addiction module killer protein
H8F46_RS00555	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H8F46_RS00625	COG3335	DDE superfamily endonuclease
H8F46_RS00675	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H8F46_RS00705	COG3423	Transcriptional regulator
H8F46_RS00825	COG3209	COG3209 Rhs family protein
H8F46_RS00825	COG4104	PAAR repeat-containing protein
H8F46_RS00840	COG3328	transposase activity
H8F46_RS00855	COG0582	viral genome integration into host DNA
H8F46_RS00865	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
H8F46_RS00870	COG2501	S4 domain
H8F46_RS00890	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H8F46_RS00910	COG0534	Mate efflux family protein
H8F46_RS00925	COG3293	Transposase
H8F46_RS00955	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H8F46_RS00960	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H8F46_RS00965	COG0675	Transposase, IS605 OrfB family
H8F46_RS00970	COG2991	Protein conserved in bacteria
H8F46_RS00975	COG1477	protein flavinylation
H8F46_RS00980	COG2871	sodium ion transport
H8F46_RS00985	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
H8F46_RS00990	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
H8F46_RS00995	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
H8F46_RS01000	COG1805	sodium ion transport
H8F46_RS01005	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
H8F46_RS01010	COG3034	peptidoglycan biosynthetic process
H8F46_RS01015	COG0121	glutamine amidotransferase
H8F46_RS01020	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
H8F46_RS01025	COG1960	acyl-CoA dehydrogenase activity
H8F46_RS01035	COG0583	DNA-binding transcription factor activity
H8F46_RS01040	COG0583	DNA-binding transcription factor activity
H8F46_RS01055	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
H8F46_RS01060	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H8F46_RS01065	COG0189	ligase activity
H8F46_RS01070	COG1678	Uncharacterized ACR, COG1678
H8F46_RS01075	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H8F46_RS01080	COG2805	Type II/IV secretion system protein
H8F46_RS01085	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
H8F46_RS01090	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
H8F46_RS01095	COG0762	integral membrane protein
H8F46_RS01100	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
H8F46_RS01105	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H8F46_RS01110	COG0066	3-isopropylmalate dehydratase activity
H8F46_RS01115	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H8F46_RS01120	COG0583	DNA-binding transcription factor activity
H8F46_RS01130	COG1881	PFAM PEBP family protein
H8F46_RS01135	COG4607	ABC-type enterochelin transport system periplasmic component
H8F46_RS01145	COG2066	Belongs to the glutaminase family
H8F46_RS01150	COG3171	Protein conserved in bacteria
H8F46_RS01155	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H8F46_RS01160	COG1194	a g-specific adenine glycosylase
H8F46_RS01165	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
H8F46_RS01170	COG0741	lytic transglycosylase activity
H8F46_RS01180	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
H8F46_RS01220	COG2801	Transposase and inactivated derivatives
H8F46_RS01255	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
H8F46_RS01265	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
H8F46_RS01270	COG2801	Transposase and inactivated derivatives
H8F46_RS01320	COG3615	Tellurite resistance protein tehB
H8F46_RS01320	COG0500	methyltransferase
H8F46_RS01330	COG1028	Short-chain dehydrogenase reductase Sdr
H8F46_RS01340	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H8F46_RS01360	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H8F46_RS01380	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
H8F46_RS01390	COG1309	transcriptional regulator
H8F46_RS01395	COG4232	protein-disulfide reductase activity
H8F46_RS01400	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
H8F46_RS01405	COG1027	Aspartate ammonia-lyase
H8F46_RS01420	COG0459	protein refolding
H8F46_RS01430	COG1509	lysine 2,3-aminomutase activity
H8F46_RS01435	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H8F46_RS01445	COG3423	Transcriptional regulator
H8F46_RS01460	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H8F46_RS01470	COG1012	belongs to the aldehyde dehydrogenase family
H8F46_RS01485	COG2813	Specifically methylates the guanine in position
H8F46_RS01490	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
H8F46_RS01575	COG3423	Transcriptional regulator
H8F46_RS01580	COG3335	DDE superfamily endonuclease
H8F46_RS01590	COG3293	Transposase
H8F46_RS01605	COG2801	Transposase and inactivated derivatives
H8F46_RS01620	COG3547	Transposase (IS116 IS110 IS902 family)
H8F46_RS01645	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H8F46_RS01700	COG3501	Rhs element vgr protein
H8F46_RS01715	COG3423	Transcriptional regulator
H8F46_RS01770	COG4372	Transposase
H8F46_RS01775	COG3436	PFAM IS66 Orf2 family protein
H8F46_RS01840	COG3962	Belongs to the TPP enzyme family
H8F46_RS01845	COG0673	inositol 2-dehydrogenase activity
H8F46_RS01850	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H8F46_RS01855	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H8F46_RS01865	COG3718	enzyme involved in inositol metabolism
H8F46_RS01895	COG2862	Uncharacterized protein family, UPF0114
H8F46_RS01910	COG1358	cellular component organization or biogenesis
H8F46_RS01950	COG5433	transposase activity
H8F46_RS01975	COG3344	reverse transcriptase
H8F46_RS01985	COG3335	DDE superfamily endonuclease
H8F46_RS02025	COG5433	transposase activity
H8F46_RS02030	COG5464	transposase or invertase
H8F46_RS02065	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
H8F46_RS02070	COG4208	sulfate ABC transporter
H8F46_RS02075	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
H8F46_RS02120	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
H8F46_RS02125	COG2867	negative regulation of translational initiation
H8F46_RS02130	COG2914	Belongs to the UPF0125 (RnfH) family
H8F46_RS02135	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H8F46_RS02140	COG0497	DNA recombination
H8F46_RS02145	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H8F46_RS02150	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
H8F46_RS02155	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
H8F46_RS02170	COG0513	Belongs to the DEAD box helicase family
H8F46_RS02175	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
H8F46_RS02180	COG1595	DNA-templated transcription, initiation
H8F46_RS02195	COG3086	response to oxidative stress
H8F46_RS02200	COG0481	GTPase activity
H8F46_RS02205	COG0681	Belongs to the peptidase S26 family
H8F46_RS02210	COG0571	ribonuclease III activity
H8F46_RS02220	COG1381	Involved in DNA repair and RecF pathway recombination
H8F46_RS02225	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
H8F46_RS02230	COG0736	holo-[acyl-carrier-protein] synthase activity
H8F46_RS02235	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H8F46_RS02245	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
H8F46_RS02255	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
H8F46_RS02260	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H8F46_RS02260	COG0047	phosphoribosylformylglycinamidine synthase activity
H8F46_RS02265	COG2205	protein histidine kinase activity
H8F46_RS02270	COG3170	Tfp pilus assembly protein FimV
H8F46_RS02275	COG2204	response regulator
H8F46_RS02280	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H8F46_RS02280	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H8F46_RS02285	COG0347	Belongs to the P(II) protein family
H8F46_RS02290	COG1017	nitric oxide dioxygenase activity
H8F46_RS02290	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H8F46_RS02295	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H8F46_RS02300	COG2814	Major facilitator Superfamily
H8F46_RS02310	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
H8F46_RS02315	COG1959	2 iron, 2 sulfur cluster binding
H8F46_RS02320	COG1104	cysteine desulfurase activity
H8F46_RS02325	COG0822	iron-sulfur transferase activity
H8F46_RS02330	COG0316	Belongs to the HesB IscA family
H8F46_RS02335	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
H8F46_RS02340	COG0443	Heat shock 70 kDa protein
H8F46_RS02345	COG0633	Ferredoxin
H8F46_RS02350	COG2975	iron-sulfur cluster assembly
H8F46_RS02355	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H8F46_RS02365	COG2373	Large extracellular alpha-helical protein
H8F46_RS02370	COG4953	penicillin-binding protein 1C
H8F46_RS02375	COG0105	UTP biosynthetic process
H8F46_RS02380	COG0820	rRNA (adenine-C2-)-methyltransferase activity
H8F46_RS02395	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
H8F46_RS02405	COG0124	histidyl-tRNA synthetase
H8F46_RS02410	COG2976	Protein conserved in bacteria
H8F46_RS02415	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H8F46_RS02420	COG1160	GTP binding
H8F46_RS02440	COG0408	coproporphyrinogen oxidase activity
H8F46_RS02450	COG3265	gluconokinase activity
H8F46_RS02455	COG2610	gluconate transmembrane transporter activity
H8F46_RS02460	COG2026	Addiction module toxin, RelE StbE family
H8F46_RS02495	COG2992	FlgJ-related protein
H8F46_RS02505	COG1028	Short-chain dehydrogenase reductase Sdr
H8F46_RS02505	COG1028	Short-chain dehydrogenase reductase Sdr
H8F46_RS02565	COG4974	Belongs to the 'phage' integrase family
H8F46_RS02570	COG0358	DNA primase activity
H8F46_RS02575	COG1395	domain, Protein
H8F46_RS02585	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
H8F46_RS02610	COG3501	Rhs element vgr protein
H8F46_RS02620	COG5433	transposase activity
H8F46_RS02675	COG2841	Protein conserved in bacteria
H8F46_RS02680	COG4574	serine-type endopeptidase inhibitor activity
H8F46_RS02690	COG3293	Transposase
H8F46_RS02720	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H8F46_RS02730	COG2079	MmgE PrpD family protein
H8F46_RS02735	COG0372	Belongs to the citrate synthase family
H8F46_RS02765	COG1629	transport
H8F46_RS02785	COG5433	transposase activity
H8F46_RS02800	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
H8F46_RS02805	COG1012	belongs to the aldehyde dehydrogenase family
H8F46_RS02810	COG1309	transcriptional regulator
H8F46_RS02815	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H8F46_RS02825	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H8F46_RS02830	COG2195	Cleaves the N-terminal amino acid of tripeptides
H8F46_RS02835	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
H8F46_RS02840	COG1073	alpha beta
H8F46_RS02850	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
H8F46_RS02855	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
H8F46_RS02860	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
H8F46_RS02870	COG2814	Major facilitator Superfamily
H8F46_RS02880	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
H8F46_RS02885	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H8F46_RS02890	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
H8F46_RS02915	COG2918	glutathione biosynthetic process
H8F46_RS02920	COG1854	S-ribosylhomocysteine lyase activity
H8F46_RS02925	COG3328	transposase activity
H8F46_RS02930	COG4536	flavin adenine dinucleotide binding
H8F46_RS02935	COG4137	Cytochrome C assembly protein
H8F46_RS02940	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H8F46_RS02945	COG0228	four-way junction DNA binding
H8F46_RS02950	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H8F46_RS02955	COG0336	Belongs to the RNA methyltransferase TrmD family
H8F46_RS02960	COG0335	large ribosomal subunit rRNA binding
H8F46_RS02970	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H8F46_RS02975	COG1605	Chorismate mutase
H8F46_RS02975	COG0287	Prephenate dehydrogenase
H8F46_RS02980	COG0077	Prephenate dehydratase
H8F46_RS02980	COG1605	Chorismate mutase
H8F46_RS02985	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
H8F46_RS02990	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H8F46_RS02995	COG0564	pseudouridine synthase activity
H8F46_RS03000	COG1496	oxidoreductase activity
H8F46_RS03005	COG0542	response to heat
H8F46_RS03030	COG5544	Lipoprotein
H8F46_RS03035	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H8F46_RS03040	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H8F46_RS03040	COG1042	CoA-binding domain protein
H8F46_RS03040	COG0045	succinate-CoA ligase (ADP-forming) activity
H8F46_RS03045	COG3148	PFAM DTW domain containing protein
H8F46_RS03050	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H8F46_RS03070	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H8F46_RS03075	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H8F46_RS03080	COG1120	ATPase activity
H8F46_RS03085	COG4114	ferric iron reductase
H8F46_RS03090	COG0076	glutamate decarboxylase activity
H8F46_RS03095	COG3486	L-lysine 6-monooxygenase (NADPH) activity
H8F46_RS03105	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H8F46_RS03110	COG2814	Major facilitator Superfamily
H8F46_RS03115	COG1566	PFAM secretion protein HlyD family protein
H8F46_RS03120	COG1846	Transcriptional regulator
H8F46_RS03130	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
H8F46_RS03140	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H8F46_RS03145	COG1278	Cold shock
H8F46_RS03150	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H8F46_RS03155	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H8F46_RS03160	COG0321	lipoyl(octanoyl) transferase activity
H8F46_RS03165	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H8F46_RS03170	COG2921	Belongs to the UPF0250 family
H8F46_RS03175	COG1686	Belongs to the peptidase S11 family
H8F46_RS03180	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H8F46_RS03185	COG0772	Belongs to the SEDS family
H8F46_RS03190	COG0768	penicillin binding
H8F46_RS03195	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
H8F46_RS03200	COG0799	negative regulation of ribosome biogenesis
H8F46_RS03210	COG1466	dna polymerase III delta subunit
H8F46_RS03215	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
H8F46_RS03220	COG0495	leucyl-tRNA aminoacylation
H8F46_RS03225	COG1126	abc transporter atp-binding protein
H8F46_RS03230	COG0765	amino acid transport
H8F46_RS03235	COG0765	amino acid transport
H8F46_RS03245	COG0815	Transfers the fatty acyl group on membrane lipoproteins
H8F46_RS03250	COG4535	Mg2 and Co2 transporter CorC
H8F46_RS03255	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
H8F46_RS03260	COG1702	phosphate starvation-inducible protein PhoH
H8F46_RS03265	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H8F46_RS03270	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H8F46_RS03315	COG1846	Transcriptional regulator
H8F46_RS03315	COG1940	carbohydrate kinase activity
H8F46_RS03320	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
H8F46_RS03325	COG0363	glucosamine-6-phosphate deaminase activity
H8F46_RS03330	COG1263	PTS System
H8F46_RS03330	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H8F46_RS03330	COG2190	(PTS) system
H8F46_RS03340	COG2801	Transposase and inactivated derivatives
H8F46_RS03355	COG0716	FMN binding
H8F46_RS03360	COG0735	belongs to the Fur family
H8F46_RS03370	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H8F46_RS03390	COG0673	inositol 2-dehydrogenase activity
H8F46_RS03425	COG2801	Transposase and inactivated derivatives
H8F46_RS03475	COG4977	sequence-specific DNA binding
H8F46_RS03505	COG2994	toxin metabolic process
H8F46_RS03510	COG1073	alpha beta
H8F46_RS03510	COG3064	Membrane
H8F46_RS03510	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
H8F46_RS03525	COG2264	protein methyltransferase activity
H8F46_RS03530	COG0596	Alpha beta hydrolase
H8F46_RS03535	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
H8F46_RS03540	COG0033	Phosphoglucomutase
H8F46_RS03550	COG1418	mRNA catabolic process
H8F46_RS03555	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H8F46_RS03565	COG0745	RESPONSE REGULATOR receiver
H8F46_RS03570	COG2205	protein histidine kinase activity
H8F46_RS03575	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
H8F46_RS03580	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
H8F46_RS03585	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
H8F46_RS03600	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
H8F46_RS03610	COG2814	Major facilitator Superfamily
H8F46_RS03630	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
H8F46_RS03635	COG1053	succinate dehydrogenase
H8F46_RS03640	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H8F46_RS03645	COG0567	Dehydrogenase, E1 component
H8F46_RS03650	COG0508	dehydrogenase complex catalyzes the overall conversion of
H8F46_RS03655	COG0045	succinate-CoA ligase (ADP-forming) activity
H8F46_RS03660	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
H8F46_RS03665	COG1271	oxidase subunit
H8F46_RS03670	COG1294	oxidase, subunit
H8F46_RS03675	COG4890	Cyd operon protein YbgT
H8F46_RS03680	COG3790	cyd operon protein YbgE
H8F46_RS03685	COG0824	Thioesterase
H8F46_RS03690	COG0811	peptide transport
H8F46_RS03695	COG0848	biopolymer transport protein
H8F46_RS03700	COG3064	Membrane
H8F46_RS03705	COG0823	Involved in the tonB-independent uptake of proteins
H8F46_RS03710	COG2885	chlorophyll binding
H8F46_RS03715	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
H8F46_RS03735	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H8F46_RS03740	COG0588	phosphoglycerate mutase activity
H8F46_RS03755	COG1119	ATPase activity
H8F46_RS03760	COG2005	Transcriptional regulator
H8F46_RS03760	COG3585	molybdate ion transport
H8F46_RS03770	COG0477	Major facilitator Superfamily
H8F46_RS03775	COG0725	ABC transporter, periplasmic molybdate-binding protein
H8F46_RS03780	COG4149	molybdate abc transporter
H8F46_RS03785	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
H8F46_RS03790	COG0561	phosphatase activity
H8F46_RS03795	COG2706	6-phosphogluconolactonase activity
H8F46_RS03805	COG4106	trans-aconitate 2-methyltransferase activity
H8F46_RS03820	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
H8F46_RS03825	COG0156	8-amino-7-oxononanoate synthase activity
H8F46_RS03830	COG2226	methyltransferase
H8F46_RS03835	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
H8F46_RS03840	COG0556	nucleotide-excision repair
H8F46_RS03845	COG0391	Required for morphogenesis under gluconeogenic growth conditions
H8F46_RS03850	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H8F46_RS03860	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
H8F46_RS03865	COG0314	molybdopterin synthase activity
H8F46_RS03870	COG0670	Belongs to the BI1 family
H8F46_RS03880	COG0842	Transport permease protein
H8F46_RS03885	COG0842	Transport permease protein
H8F46_RS03890	COG1131	(ABC) transporter
H8F46_RS03900	COG1309	transcriptional regulator
H8F46_RS03905	COG0513	Belongs to the DEAD box helicase family
H8F46_RS03910	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H8F46_RS03930	COG3209	COG3209 Rhs family protein
H8F46_RS03945	COG4974	Belongs to the 'phage' integrase family
H8F46_RS03955	COG0358	DNA primase activity
H8F46_RS03960	COG1395	domain, Protein
H8F46_RS03990	COG4974	Belongs to the 'phage' integrase family
H8F46_RS03995	COG0358	DNA primase activity
H8F46_RS04000	COG1395	domain, Protein
H8F46_RS04015	COG3209	COG3209 Rhs family protein
H8F46_RS04030	COG3501	Rhs element vgr protein
H8F46_RS04065	COG3082	Protein of unknown function (DUF1414)
H8F46_RS04070	COG3081	Nucleoid-associated protein
H8F46_RS04075	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
H8F46_RS04080	COG1061	Type III restriction enzyme res subunit
H8F46_RS04085	COG1187	pseudouridine synthase activity
H8F46_RS04090	COG2814	Major facilitator Superfamily
H8F46_RS04100	COG0791	NLP P60 protein
H8F46_RS04105	COG0671	phosphoesterase, PA-phosphatase related
H8F46_RS04115	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
H8F46_RS04120	COG0625	glutathione transferase activity
H8F46_RS04125	COG1090	epimerase
H8F46_RS04130	COG0163	prenyltransferase activity
H8F46_RS04135	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
H8F46_RS04140	COG1286	toxin biosynthetic process
H8F46_RS04145	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
H8F46_RS04150	COG0285	dihydrofolate synthase activity
H8F46_RS04155	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
H8F46_RS04160	COG0586	Pfam SNARE associated Golgi protein
H8F46_RS04165	COG0101	tRNA pseudouridine synthase activity
H8F46_RS04170	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H8F46_RS04175	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H8F46_RS04180	COG2207	Transcriptional regulator
H8F46_RS04190	COG0642	Histidine kinase
H8F46_RS04205	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H8F46_RS04210	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H8F46_RS04210	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
H8F46_RS04225	COG3101	peptidyl-lysine hydroxylation
H8F46_RS04230	COG0730	response to heat
H8F46_RS04235	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
H8F46_RS04250	COG2986	histidine ammonia-lyase
H8F46_RS04255	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
H8F46_RS04265	COG0010	Belongs to the arginase family
H8F46_RS04270	COG1228	amidohydrolase
H8F46_RS04275	COG2840	Smr protein MutS2
H8F46_RS04280	COG2062	phosphohistidine phosphatase, SixA
H8F46_RS04285	COG1024	Enoyl-CoA hydratase
H8F46_RS04285	COG1250	3-hydroxyacyl-CoA dehydrogenase
H8F46_RS04290	COG0183	Belongs to the thiolase family
H8F46_RS04295	COG3691	Protein conserved in bacteria
H8F46_RS04300	COG2067	long-chain fatty acid transport protein
H8F46_RS04325	COG0727	PFAM Uncharacterised protein family (UPF0153)
H8F46_RS04370	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H8F46_RS04385	COG3530	Putative quorum-sensing-regulated virulence factor
H8F46_RS04390	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H8F46_RS04395	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H8F46_RS04400	COG3115	cell septum assembly
H8F46_RS04410	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H8F46_RS04415	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H8F46_RS04425	COG2190	(PTS) system
H8F46_RS04455	COG2249	NAD(P)H dehydrogenase (quinone) activity
H8F46_RS04475	COG1028	Short-chain dehydrogenase reductase Sdr
H8F46_RS04480	COG1028	Short-chain dehydrogenase reductase Sdr
H8F46_RS04485	COG4221	oxidoreductase activity
H8F46_RS04490	COG0574	Belongs to the PEP-utilizing enzyme family
H8F46_RS04490	COG3848	Pyruvate phosphate dikinase
H8F46_RS04495	COG3328	transposase activity
H8F46_RS04515	COG3023	N-Acetylmuramoyl-L-alanine amidase
H8F46_RS04520	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H8F46_RS04530	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H8F46_RS04535	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H8F46_RS04545	COG0784	Response regulator, receiver
H8F46_RS04545	COG2205	protein histidine kinase activity
H8F46_RS04550	COG2197	response regulator
H8F46_RS04555	COG2198	Histidine kinase
H8F46_RS04555	COG0642	Histidine kinase
H8F46_RS04570	COG0814	amino acid
H8F46_RS04585	COG1441	menaquinone biosynthetic process
H8F46_RS04590	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
H8F46_RS04595	COG0596	Alpha beta hydrolase
H8F46_RS04600	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
H8F46_RS04610	COG1169	isochorismate synthase
H8F46_RS04615	COG0457	Tetratricopeptide repeat
H8F46_RS04620	COG1649	PFAM Uncharacterised BCR, COG1649
H8F46_RS04620	COG0726	polysaccharide deacetylase
H8F46_RS04625	COG1215	transferase activity, transferring glycosyl groups
H8F46_RS04640	COG2199	diguanylate cyclase activity
H8F46_RS04645	COG2885	chlorophyll binding
H8F46_RS04650	COG2771	luxR family
H8F46_RS04650	COG2200	EAL domain
H8F46_RS04680	COG3037	sugar-specific permease SgaT UlaA
H8F46_RS04690	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H8F46_RS04695	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H8F46_RS04700	COG1007	ATP synthesis coupled electron transport
H8F46_RS04705	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H8F46_RS04710	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H8F46_RS04715	COG0713	ATP synthesis coupled electron transport
H8F46_RS04720	COG0839	Belongs to the complex I subunit 6 family
H8F46_RS04725	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H8F46_RS04735	COG1034	ATP synthesis coupled electron transport
H8F46_RS04740	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
H8F46_RS04750	COG0649	NAD binding
H8F46_RS04750	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H8F46_RS04755	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H8F46_RS04760	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H8F46_RS04765	COG0583	DNA-binding transcription factor activity
H8F46_RS04770	COG0436	Aminotransferase
H8F46_RS04780	COG0471	metal ion transport
H8F46_RS04780	COG0490	domain, Protein
H8F46_RS04785	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H8F46_RS04790	COG3092	negative regulation of chromosome organization
H8F46_RS04795	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H8F46_RS04800	COG0280	phosphate acetyltransferase
H8F46_RS04800	COG0857	belongs to the CobB CobQ family
H8F46_RS04865	COG5433	transposase activity
H8F46_RS04875	COG4615	Cyclic peptide transporter
H8F46_RS04935	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H8F46_RS04945	COG1105	Belongs to the carbohydrate kinase PfkB family
H8F46_RS04950	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
H8F46_RS04955	COG2855	membrane
H8F46_RS04960	COG0583	DNA-binding transcription factor activity
H8F46_RS04965	COG0833	amino acid
H8F46_RS04975	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H8F46_RS04980	COG1120	ATPase activity
H8F46_RS04985	COG4771	TonB-dependent receptor
H8F46_RS04990	COG0531	amino acid
H8F46_RS04995	COG0277	FAD linked oxidase domain protein
H8F46_RS05000	COG2925	Exonuclease
H8F46_RS05005	COG2926	Belongs to the UPF0265 family
H8F46_RS05020	COG5441	Belongs to the UPF0261 family
H8F46_RS05025	COG5564	TIM-barrel signal transduction protein
H8F46_RS05035	COG0702	epimerase
H8F46_RS05045	COG1530	ribonuclease E activity
H8F46_RS05050	COG0564	pseudouridine synthase activity
H8F46_RS05055	COG0424	maF-like protein
H8F46_RS05060	COG1399	metal-binding, possibly nucleic acid-binding protein
H8F46_RS05065	COG0333	Belongs to the bacterial ribosomal protein bL32 family
H8F46_RS05070	COG0416	fatty acid biosynthetic process
H8F46_RS05075	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H8F46_RS05080	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H8F46_RS05090	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H8F46_RS05095	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H8F46_RS05100	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H8F46_RS05105	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H8F46_RS05110	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
H8F46_RS05115	COG0470	DNA polymerase III
H8F46_RS05120	COG0084	hydrolase, TatD family'
H8F46_RS05125	COG0537	adenosine 5'-monophosphoramidase activity
H8F46_RS05130	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
H8F46_RS05140	COG1472	Belongs to the glycosyl hydrolase 3 family
H8F46_RS05145	COG1252	NADH dehydrogenase
H8F46_RS05150	COG3134	Outer membrane lipoprotein
H8F46_RS05155	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H8F46_RS05160	COG4591	ABC-type transport system involved in lipoprotein release permease component
H8F46_RS05165	COG1136	(ABC) transporter
H8F46_RS05170	COG4591	ABC-type transport system involved in lipoprotein release permease component
H8F46_RS05195	COG2850	peptidyl-arginine hydroxylation
H8F46_RS05205	COG0745	RESPONSE REGULATOR receiver
H8F46_RS05210	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H8F46_RS05215	COG2915	High frequency lysogenization protein hflD homolog
H8F46_RS05220	COG0482	sulfurtransferase activity
H8F46_RS05230	COG1187	pseudouridine synthase activity
H8F46_RS05235	COG0538	isocitrate dehydrogenase activity
H8F46_RS05265	COG1115	amino acid carrier protein
H8F46_RS05270	COG3023	N-Acetylmuramoyl-L-alanine amidase
H8F46_RS05275	COG2207	Transcriptional regulator
H8F46_RS05275	COG3708	Transcriptional regulator
H8F46_RS05295	COG0351	phosphomethylpyrimidine kinase
H8F46_RS05300	COG1830	Aldolase
H8F46_RS05305	COG0826	peptidase U32
H8F46_RS05310	COG2814	Major facilitator Superfamily
H8F46_RS05315	COG0745	RESPONSE REGULATOR receiver
H8F46_RS05320	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H8F46_RS05325	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H8F46_RS05330	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H8F46_RS05340	COG2239	Acts as a magnesium transporter
H8F46_RS05350	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
H8F46_RS05355	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H8F46_RS05360	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H8F46_RS05365	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
H8F46_RS05370	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
H8F46_RS05375	COG2233	PERMEase
H8F46_RS05380	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
H8F46_RS05385	COG1393	Belongs to the ArsC family
H8F46_RS05390	COG4783	chaperone-mediated protein folding
H8F46_RS05395	COG0628	permease
H8F46_RS05400	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H8F46_RS05405	COG2716	regulation of RNA biosynthetic process
H8F46_RS05410	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H8F46_RS05415	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
H8F46_RS05420	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
H8F46_RS05425	COG2707	UPF0756 membrane protein
H8F46_RS05430	COG1444	tRNA N-acetyltransferase activity
H8F46_RS05440	COG1876	peptidase activity
H8F46_RS05445	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H8F46_RS05450	COG1393	Belongs to the ArsC family
H8F46_RS05455	COG2197	response regulator
H8F46_RS05475	COG1770	oligopeptidase
H8F46_RS05535	COG4171	peptide transport system, permease
H8F46_RS05545	COG4166	transmembrane transport
H8F46_RS05550	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
H8F46_RS05555	COG1842	Phage shock protein A
H8F46_RS05565	COG1983	PspC domain protein
H8F46_RS05570	COG3106	COG3106 Predicted ATPase
H8F46_RS05590	COG0598	Magnesium transport protein CorA
H8F46_RS05595	COG0037	tRNA processing
H8F46_RS05610	COG3423	Transcriptional regulator
H8F46_RS05620	COG1113	amino acid transport
H8F46_RS05645	COG1214	PFAM Peptidase M22, glycoprotease
H8F46_RS05645	COG0456	acetyltransferase
H8F46_RS05650	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H8F46_RS05650	COG2169	Transcriptional regulator
H8F46_RS05665	COG2197	response regulator
H8F46_RS05670	COG0322	excinuclease ABC activity
H8F46_RS05675	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H8F46_RS05695	COG0582	viral genome integration into host DNA
H8F46_RS05775	COG3111	PFAM Bacterial OB fold (BOF) protein
H8F46_RS05820	COG3328	transposase activity
H8F46_RS05855	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
H8F46_RS05860	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H8F46_RS05865	COG2186	Transcriptional regulator
H8F46_RS06010	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H8F46_RS06015	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H8F46_RS06030	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H8F46_RS06035	COG3139	Protein of unknown function (DUF1315)
H8F46_RS06055	COG1335	isochorismatase
H8F46_RS06060	COG0252	asparaginase activity
H8F46_RS06070	COG0616	signal peptide processing
H8F46_RS06075	COG0778	Nitroreductase
H8F46_RS06080	COG0709	Synthesizes selenophosphate from selenide and ATP
H8F46_RS06085	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H8F46_RS06110	COG0788	formyltetrahydrofolate deformylase activity
H8F46_RS06115	COG3012	SEC-C Motif Domain Protein
H8F46_RS06120	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H8F46_RS06140	COG1435	thymidine kinase activity
H8F46_RS06145	COG1454	alcohol dehydrogenase
H8F46_RS06145	COG1012	belongs to the aldehyde dehydrogenase family
H8F46_RS06150	COG2095	MarC family integral membrane protein
H8F46_RS06170	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H8F46_RS06175	COG0444	Belongs to the ABC transporter superfamily
H8F46_RS06180	COG4608	Belongs to the ABC transporter superfamily
H8F46_RS06195	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H8F46_RS06260	COG3099	Belongs to the UPF0263 family
H8F46_RS06280	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
H8F46_RS06300	COG2917	probably involved in intracellular septation
H8F46_RS06315	COG3047	cAMP biosynthetic process
H8F46_RS06320	COG0159	tryptophan synthase activity
H8F46_RS06325	COG0133	tryptophan synthase activity
H8F46_RS06335	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H8F46_RS06365	COG0009	L-threonylcarbamoyladenylate synthase
H8F46_RS06380	COG1028	Short-chain dehydrogenase reductase Sdr
H8F46_RS06385	COG0616	signal peptide processing
H8F46_RS06400	COG0583	DNA-binding transcription factor activity
H8F46_RS06410	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
H8F46_RS06420	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
H8F46_RS06425	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
H8F46_RS06430	COG0284	orotidine-5'-phosphate decarboxylase activity
H8F46_RS06435	COG0023	Translation Initiation Factor
H8F46_RS06455	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
H8F46_RS06495	COG2801	Transposase and inactivated derivatives
H8F46_RS06500	COG3328	transposase activity
H8F46_RS06505	COG2801	Transposase and inactivated derivatives
H8F46_RS06530	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H8F46_RS06540	COG4659	FMN binding
H8F46_RS06560	COG4657	Part of a membrane complex involved in electron transport
H8F46_RS06570	COG0673	inositol 2-dehydrogenase activity
H8F46_RS06575	COG0385	Bile acid
H8F46_RS06580	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
H8F46_RS06585	COG5339	Protein conserved in bacteria
H8F46_RS06590	COG1482	cell wall glycoprotein biosynthetic process
H8F46_RS06595	COG0114	fumarate hydratase activity
H8F46_RS06615	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
H8F46_RS06630	COG4221	oxidoreductase activity
H8F46_RS06635	COG1902	pentaerythritol trinitrate reductase activity
H8F46_RS06645	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H8F46_RS06675	COG1309	transcriptional regulator
H8F46_RS06680	COG1069	ribulokinase activity
H8F46_RS06705	COG3335	DDE superfamily endonuclease
H8F46_RS06740	COG1671	Belongs to the UPF0178 family
H8F46_RS06745	COG1396	sequence-specific DNA binding
H8F46_RS06750	COG0235	Class ii aldolase
H8F46_RS06765	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H8F46_RS06785	COG1012	belongs to the aldehyde dehydrogenase family
H8F46_RS06835	COG1073	alpha beta
H8F46_RS06835	COG3064	Membrane
H8F46_RS06835	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
H8F46_RS06860	COG1846	Transcriptional regulator
H8F46_RS06905	COG2175	clavaminate synthase activity
H8F46_RS06925	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H8F46_RS06930	COG0589	response to stress
H8F46_RS06955	COG4974	Belongs to the 'phage' integrase family
H8F46_RS06985	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
H8F46_RS06990	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
H8F46_RS07010	COG0531	amino acid
H8F46_RS07040	COG1643	Atp-dependent helicase
H8F46_RS07050	COG3784	Protein of unknown function (DUF1318)
H8F46_RS07060	COG2911	Protein conserved in bacteria
H8F46_RS07065	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H8F46_RS07075	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
H8F46_RS07090	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H8F46_RS07095	COG0494	nUDIX hydrolase
H8F46_RS07100	COG2983	Belongs to the UPF0260 family
H8F46_RS07105	COG0179	Fumarylacetoacetate (FAA) hydrolase
H8F46_RS07110	COG2951	lytic endotransglycosylase activity
H8F46_RS07115	COG3100	YcgL domain-containing protein
H8F46_RS07120	COG0850	regulation of cytokinetic process
H8F46_RS07125	COG2894	cell division
H8F46_RS07130	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
H8F46_RS07150	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
H8F46_RS07155	COG0318	PFAM AMP-dependent synthetase and ligase
H8F46_RS07160	COG3065	identical protein binding
H8F46_RS07170	COG1199	ATP-dependent helicase activity
H8F46_RS07190	COG0251	oxidation-reduction process
H8F46_RS07195	COG2076	Multidrug Resistance protein
H8F46_RS07200	COG2076	Multidrug Resistance protein
H8F46_RS07205	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
H8F46_RS07210	COG1737	Transcriptional regulator
H8F46_RS07215	COG0469	pyruvate kinase activity
H8F46_RS07230	COG1560	Kdo2-lipid A biosynthetic process
H8F46_RS07235	COG0739	heme binding
H8F46_RS07240	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
H8F46_RS07245	COG1121	(ABC) transporter
H8F46_RS07250	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H8F46_RS07285	COG0604	alcohol dehydrogenase
H8F46_RS07285	COG3321	synthase
H8F46_RS07295	COG0436	Aminotransferase
H8F46_RS07300	COG1509	lysine 2,3-aminomutase activity
H8F46_RS07305	COG2255	four-way junction helicase activity
H8F46_RS07310	COG0632	four-way junction helicase activity
H8F46_RS07315	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
H8F46_RS07320	COG0217	transcriptional regulatory protein
H8F46_RS07325	COG0494	nUDIX hydrolase
H8F46_RS07330	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
H8F46_RS07335	COG3788	relative of glutathione S-transferase, MAPEG superfamily
H8F46_RS07340	COG2226	methyltransferase
H8F46_RS07345	COG0500	methyltransferase
H8F46_RS07350	COG3142	Participates in the control of copper homeostasis
H8F46_RS07355	COG3102	Protein conserved in bacteria
H8F46_RS07360	COG0018	arginyl-trna synthetase
H8F46_RS07365	COG0728	peptidoglycan biosynthetic process
H8F46_RS07370	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H8F46_RS07375	COG0477	Major facilitator Superfamily
H8F46_RS07385	COG3381	protein complex oligomerization
H8F46_RS07390	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H8F46_RS07400	COG1028	Short-chain dehydrogenase reductase Sdr
H8F46_RS07400	COG3321	synthase
H8F46_RS07400	COG0604	alcohol dehydrogenase
H8F46_RS07415	COG2378	regulation of single-species biofilm formation
H8F46_RS07425	COG5301	cellulose 1,4-beta-cellobiosidase activity
H8F46_RS07435	COG0659	secondary active sulfate transmembrane transporter activity
H8F46_RS07440	COG3604	Transcriptional regulator
H8F46_RS07465	COG2144	transferase activity, transferring acyl groups
H8F46_RS07475	COG2072	flavoprotein involved in K transport
H8F46_RS07480	COG2877	3-deoxy-8-phosphooctulonate synthase activity
H8F46_RS07490	COG2890	protein-(glutamine-N5) methyltransferase activity
H8F46_RS07495	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H8F46_RS07500	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
H8F46_RS07505	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
H8F46_RS07510	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
H8F46_RS07515	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H8F46_RS07530	COG0193	aminoacyl-tRNA hydrolase activity
H8F46_RS07535	COG0012	GTP binding
H8F46_RS07540	COG0402	S-adenosylhomocysteine deaminase activity
H8F46_RS07585	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H8F46_RS07595	COG1271	oxidase subunit
H8F46_RS07600	COG1294	oxidase, subunit
H8F46_RS07610	COG1702	phosphate starvation-inducible protein PhoH
H8F46_RS07615	COG2356	endonuclease I
H8F46_RS07630	COG0589	response to stress
H8F46_RS07635	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H8F46_RS07640	COG2313	pseudouridylate synthase activity
H8F46_RS07645	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H8F46_RS07650	COG0531	amino acid
H8F46_RS07655	COG1982	Orn Lys Arg decarboxylase major
H8F46_RS07750	COG0076	glutamate decarboxylase activity
H8F46_RS07765	COG0501	Belongs to the peptidase M48B family
H8F46_RS07800	COG5464	transposase or invertase
H8F46_RS07820	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H8F46_RS07835	COG4372	Transposase
H8F46_RS07840	COG3436	PFAM IS66 Orf2 family protein
H8F46_RS07860	COG1278	Cold shock
H8F46_RS07895	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
H8F46_RS07945	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
H8F46_RS07950	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H8F46_RS07955	COG0259	pyridoxamine-phosphate oxidase activity
H8F46_RS07960	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
H8F46_RS07965	COG3133	Outer membrane lipoprotein
H8F46_RS07970	COG1846	Transcriptional regulator
H8F46_RS07975	COG3313	Fe-S protein
H8F46_RS07980	COG0346	lactoylglutathione lyase activity
H8F46_RS07985	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H8F46_RS07990	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H8F46_RS08000	COG1609	Transcriptional regulator
H8F46_RS08005	COG0583	DNA-binding transcription factor activity
H8F46_RS08010	COG2814	Major facilitator Superfamily
H8F46_RS08015	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H8F46_RS08020	COG0307	riboflavin synthase, alpha
H8F46_RS08025	COG0534	Mate efflux family protein
H8F46_RS08050	COG4238	major outer membrane lipoprotein
H8F46_RS08055	COG1388	LysM domain
H8F46_RS08055	COG1376	ErfK ybiS ycfS ynhG family protein
H8F46_RS08060	COG2050	protein possibly involved in aromatic compounds catabolism
H8F46_RS08065	COG0247	lactate metabolic process
H8F46_RS08065	COG0277	FAD linked oxidase domain protein
H8F46_RS08070	COG0628	permease
H8F46_RS08075	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H8F46_RS08075	COG0574	Belongs to the PEP-utilizing enzyme family
H8F46_RS08080	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
H8F46_RS08100	COG3720	iron ion transport
H8F46_RS08105	COG4558	Periplasmic binding protein
H8F46_RS08110	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H8F46_RS08115	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
H8F46_RS08125	COG2207	Transcriptional regulator
H8F46_RS08130	COG0095	Lipoate-protein ligase
H8F46_RS08145	COG1598	PFAM Uncharacterised protein family UPF0150
H8F46_RS08155	COG0791	NLP P60 protein
H8F46_RS08160	COG2076	Multidrug Resistance protein
H8F46_RS08165	COG2076	Multidrug Resistance protein
H8F46_RS08170	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
H8F46_RS08175	COG0726	polysaccharide deacetylase
H8F46_RS08180	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H8F46_RS08180	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H8F46_RS08185	COG0463	Glycosyl transferase, family 2
H8F46_RS08190	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H8F46_RS08195	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
H8F46_RS08200	COG4139	cobalamin transport
H8F46_RS08205	COG0776	regulation of translation
H8F46_RS08210	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H8F46_RS08210	COG0072	phenylalanine-tRNA ligase activity
H8F46_RS08230	COG0291	Belongs to the bacterial ribosomal protein bL35 family
H8F46_RS08235	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
H8F46_RS08240	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H8F46_RS08250	COG0803	Belongs to the bacterial solute-binding protein 9 family
H8F46_RS08255	COG1121	(ABC) transporter
H8F46_RS08260	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H8F46_RS08265	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H8F46_RS08270	COG3001	Fructosamine kinase
H8F46_RS08280	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H8F46_RS08285	COG1988	membrane-bound metal-dependent
H8F46_RS08300	COG3344	reverse transcriptase
H8F46_RS08310	COG1823	symporter activity
H8F46_RS08315	COG0501	Belongs to the peptidase M48B family
H8F46_RS08325	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
H8F46_RS08330	COG1956	GAF domain-containing protein
H8F46_RS08340	COG1276	copper resistance
H8F46_RS08345	COG2372	response to copper ion
H8F46_RS08350	COG1528	Iron-storage protein
H8F46_RS08370	COG3140	Belongs to the UPF0181 family
H8F46_RS08380	COG0494	nUDIX hydrolase
H8F46_RS08385	COG1760	l-serine dehydratase
H8F46_RS08390	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
H8F46_RS08390	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H8F46_RS08395	COG3715	PTS system
H8F46_RS08400	COG3716	PTS system mannose fructose sorbose family IID component
H8F46_RS08405	COG4811	Protein of unknown function (DUF986)
H8F46_RS08410	COG1971	Probably functions as a manganese efflux pump
H8F46_RS08415	COG2226	methyltransferase
H8F46_RS08420	COG2271	Major facilitator Superfamily
H8F46_RS08425	COG3851	Histidine kinase
H8F46_RS08435	COG3077	Addiction module antitoxin, RelB DinJ family
H8F46_RS08445	COG2197	response regulator
H8F46_RS08460	COG2197	response regulator
H8F46_RS08475	COG0519	Catalyzes the synthesis of GMP from XMP
H8F46_RS08475	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H8F46_RS08480	COG0517	IMP dehydrogenase activity
H8F46_RS08480	COG0516	GMP reductase activity
H8F46_RS08485	COG1570	exodeoxyribonuclease VII activity
H8F46_RS08530	COG3423	Transcriptional regulator
H8F46_RS08535	COG3335	DDE superfamily endonuclease
H8F46_RS08555	COG2920	part of a sulfur-relay system
H8F46_RS08560	COG1254	Belongs to the acylphosphatase family
H8F46_RS08570	COG2801	Transposase and inactivated derivatives
H8F46_RS08580	COG1832	CoA-binding protein
H8F46_RS08585	COG1803	Methylglyoxal synthase
H8F46_RS08590	COG0210	DNA helicase
H8F46_RS08600	COG5433	transposase activity
H8F46_RS08635	COG2801	Transposase and inactivated derivatives
H8F46_RS08645	COG3210	domain, Protein
H8F46_RS08645	COG3064	Membrane
H8F46_RS08645	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
H8F46_RS08660	COG3293	Transposase
H8F46_RS08670	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
H8F46_RS08675	COG0745	RESPONSE REGULATOR receiver
H8F46_RS08680	COG2201	protein-glutamate methylesterase activity
H8F46_RS08690	COG0840	transmembrane signaling receptor activity
H8F46_RS08695	COG0840	transmembrane signaling receptor activity
H8F46_RS08700	COG0835	chemotaxis
H8F46_RS08705	COG0643	Histidine kinase
H8F46_RS08705	COG2198	Histidine kinase
H8F46_RS08715	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
H8F46_RS08740	COG0418	dihydroorotase activity
H8F46_RS08760	COG1620	l-lactate permease
H8F46_RS08765	COG1304	FMN binding
H8F46_RS08785	COG1560	Kdo2-lipid A biosynthetic process
H8F46_RS08790	COG1054	Belongs to the UPF0176 family
H8F46_RS08825	COG5301	cellulose 1,4-beta-cellobiosidase activity
H8F46_RS08840	COG4384	Bacteriophage Mu Gp45 protein
H8F46_RS08850	COG4228	DNA circulation
H8F46_RS08865	COG4397	Mu-like prophage major head subunit gpT
H8F46_RS08870	COG4388	Caudovirus prohead serine protease
H8F46_RS08875	COG5005	Phage virion morphogenesis
H8F46_RS08880	COG2369	cell adhesion
H8F46_RS08885	COG4383	Mu-like prophage protein gp29
H8F46_RS08890	COG4373	Mu-like prophage FluMu protein gp28
H8F46_RS08900	COG0640	Transcriptional regulator
H8F46_RS08935	COG5566	PFAM Mor transcription activator
H8F46_RS08990	COG2842	Transposition protein
H8F46_RS09000	COG3423	Transcriptional regulator
H8F46_RS09060	COG3335	DDE superfamily endonuclease
H8F46_RS09080	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H8F46_RS09085	COG0506	proline dehydrogenase activity
H8F46_RS09085	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
H8F46_RS09085	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
H8F46_RS09095	COG1191	sigma factor activity
H8F46_RS09130	COG1677	Flagellar hook-basal body complex protein FliE
H8F46_RS09135	COG1766	The M ring may be actively involved in energy transduction
H8F46_RS09150	COG1157	protein secretion by the type III secretion system
H8F46_RS09165	COG1580	Controls the rotational direction of flagella during chemotaxis
H8F46_RS09200	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
H8F46_RS09240	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H8F46_RS09245	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H8F46_RS09245	COG1028	Short-chain dehydrogenase reductase Sdr
H8F46_RS09245	COG3321	synthase
H8F46_RS09245	COG4221	oxidoreductase activity
H8F46_RS09265	COG1250	3-hydroxyacyl-CoA dehydrogenase
H8F46_RS09285	COG1104	cysteine desulfurase activity
H8F46_RS09295	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H8F46_RS09305	COG1705	Flagellar rod assembly protein muramidase FlgJ
H8F46_RS09305	COG3951	Flagellar rod assembly protein muramidase FlgJ
H8F46_RS09310	COG1706	bacterial-type flagellum-dependent cell motility
H8F46_RS09315	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
H8F46_RS09340	COG1558	bacterial-type flagellum-dependent cell motility
H8F46_RS09345	COG1815	bacterial-type flagellum-dependent cell motility
H8F46_RS09375	COG3121	Chaperone
H8F46_RS09385	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H8F46_RS09390	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H8F46_RS09460	COG2831	hemolysin activation secretion protein
H8F46_RS09505	COG3335	DDE superfamily endonuclease
H8F46_RS09520	COG3070	regulator of competence-specific genes
H8F46_RS09525	COG5404	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
H8F46_RS09530	COG2885	chlorophyll binding
H8F46_RS09530	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
H8F46_RS09535	COG3120	sequence-specific DNA binding
H8F46_RS09540	COG1067	ATP-dependent peptidase activity
H8F46_RS09545	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H8F46_RS09550	COG3130	regulation of translation
H8F46_RS09555	COG3009	Protein conserved in bacteria
H8F46_RS09560	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H8F46_RS09560	COG3008	intermembrane lipid transfer
H8F46_RS09565	COG2995	paraquat-inducible protein a
H8F46_RS09570	COG0488	(ABC) transporter
H8F46_RS09575	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H8F46_RS09575	COG0116	Belongs to the methyltransferase superfamily
H8F46_RS09580	COG3217	Mosc domain protein beta barrel domain protein
H8F46_RS09580	COG0633	Ferredoxin
H8F46_RS09590	COG0167	dihydroorotate dehydrogenase activity
H8F46_RS09595	COG0308	aminopeptidase N
H8F46_RS09600	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
H8F46_RS09605	COG0017	Asparaginyl-tRNA synthetase
H8F46_RS09610	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
H8F46_RS09615	COG1448	Aminotransferase
H8F46_RS09620	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H8F46_RS09625	COG3108	Peptidase M15
H8F46_RS09630	COG2989	Protein conserved in bacteria
H8F46_RS09635	COG3700	Belongs to the class B bacterial acid phosphatase family
H8F46_RS09640	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
H8F46_RS09645	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
H8F46_RS09650	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
H8F46_RS09655	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H8F46_RS09660	COG1434	Gram-negative-bacterium-type cell wall biogenesis
H8F46_RS09665	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
H8F46_RS09670	COG2835	tetraacyldisaccharide 4'-kinase activity
H8F46_RS09675	COG1663	tetraacyldisaccharide 4'-kinase activity
H8F46_RS09680	COG1132	(ABC) transporter
H8F46_RS09685	COG2333	competence protein COMEC
H8F46_RS09685	COG0658	competence protein
H8F46_RS09695	COG0539	negative regulation of cytoplasmic translation
H8F46_RS09700	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
H8F46_RS09705	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H8F46_RS09710	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
H8F46_RS09720	COG0252	asparaginase activity
H8F46_RS09725	COG1944	ATP diphosphatase activity
H8F46_RS09730	COG2116	formate transmembrane transporter activity
H8F46_RS09735	COG1882	Formate acetyltransferase
H8F46_RS09740	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
H8F46_RS09750	COG3293	Transposase
H8F46_RS09755	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
H8F46_RS09760	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H8F46_RS09765	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
H8F46_RS09770	COG3107	peptidoglycan biosynthetic process
H8F46_RS09770	COG1674	ftsk spoiiie
H8F46_RS09775	COG1522	sequence-specific DNA binding
H8F46_RS09780	COG0492	ferredoxin-NADP+ reductase activity
H8F46_RS09790	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
H8F46_RS09795	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
H8F46_RS09805	COG0542	response to heat
H8F46_RS09810	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
H8F46_RS09815	COG1278	Cold shock
H8F46_RS09820	COG3593	DNA synthesis involved in DNA repair
H8F46_RS09825	COG2431	L-lysine efflux transmembrane transporter activity
H8F46_RS09830	COG1126	abc transporter atp-binding protein
H8F46_RS09835	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H8F46_RS09840	COG4215	(ABC) transporter
H8F46_RS09845	COG4160	amino acid transport
H8F46_RS09850	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H8F46_RS09875	COG0671	phosphoesterase, PA-phosphatase related
H8F46_RS09880	COG0814	amino acid
H8F46_RS09885	COG1686	Belongs to the peptidase S11 family
H8F46_RS09890	COG0625	glutathione transferase activity
H8F46_RS09895	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H8F46_RS09905	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H8F46_RS09910	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H8F46_RS09910	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H8F46_RS09915	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H8F46_RS09915	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H8F46_RS09920	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
H8F46_RS09920	COG0131	Imidazoleglycerol-phosphate dehydratase
H8F46_RS09925	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H8F46_RS09930	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
H8F46_RS09935	COG0107	imidazoleglycerol-phosphate synthase activity
H8F46_RS09940	COG0140	phosphoribosyl-ATP diphosphatase activity
H8F46_RS09940	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H8F46_RS09945	COG2226	methyltransferase
H8F46_RS09960	COG1454	alcohol dehydrogenase
H8F46_RS09965	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H8F46_RS09970	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
H8F46_RS09975	COG1253	flavin adenine dinucleotide binding
H8F46_RS09980	COG5301	cellulose 1,4-beta-cellobiosidase activity
H8F46_RS09985	COG2982	Protein involved in outer membrane biogenesis
H8F46_RS09990	COG0717	Belongs to the dCTP deaminase family
H8F46_RS09995	COG0572	uridine kinase
H8F46_RS10005	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H8F46_RS10005	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H8F46_RS10010	COG1380	Effector of murein hydrolase LrgA
H8F46_RS10015	COG1346	cytolysis
H8F46_RS10020	COG0295	cytidine deaminase activity
H8F46_RS10025	COG0281	malic enzyme
H8F46_RS10030	COG2949	membrane
H8F46_RS10035	COG2311	Membrane
H8F46_RS10040	COG0302	gtp cyclohydrolase
H8F46_RS10045	COG0477	Major facilitator Superfamily
H8F46_RS10055	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H8F46_RS10060	COG0488	(ABC) transporter
H8F46_RS10070	COG0454	-acetyltransferase
H8F46_RS10080	COG5006	permease, DMT superfamily
H8F46_RS10090	COG2824	Alkylphosphonate utilization operon protein PhnA
H8F46_RS10110	COG2897	thiosulfate sulfurtransferase activity
H8F46_RS10120	COG5433	transposase activity
H8F46_RS10150	COG5301	cellulose 1,4-beta-cellobiosidase activity
H8F46_RS10260	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H8F46_RS10265	COG1028	Short-chain dehydrogenase reductase Sdr
H8F46_RS10270	COG0318	PFAM AMP-dependent synthetase and ligase
H8F46_RS10285	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
H8F46_RS10305	COG1492	cobalamin metabolic process
H8F46_RS10380	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
H8F46_RS10390	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H8F46_RS10390	COG1648	precorrin-2 dehydrogenase activity
H8F46_RS10395	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H8F46_RS10415	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H8F46_RS10430	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
H8F46_RS10440	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H8F46_RS10445	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H8F46_RS10450	COG4974	Belongs to the 'phage' integrase family
H8F46_RS10455	COG0716	FMN binding
H8F46_RS10465	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
H8F46_RS10470	COG0354	folic acid binding
H8F46_RS10485	COG1216	Glycosyl transferase, family 2
H8F46_RS10485	COG1442	glycosyl transferase family 8
H8F46_RS10495	COG0463	Glycosyl transferase, family 2
H8F46_RS10515	COG1136	(ABC) transporter
H8F46_RS10515	COG0577	efflux transmembrane transporter activity
H8F46_RS10520	COG0577	efflux transmembrane transporter activity
H8F46_RS10520	COG1136	(ABC) transporter
H8F46_RS10535	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H8F46_RS10535	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H8F46_RS10540	COG0509	glycine decarboxylation via glycine cleavage system
H8F46_RS10545	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H8F46_RS10550	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H8F46_RS10555	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H8F46_RS10560	COG0006	proline dipeptidase activity
H8F46_RS10565	COG3079	Belongs to the UPF0149 family
H8F46_RS10580	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H8F46_RS10585	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H8F46_RS10590	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
H8F46_RS10595	COG0583	DNA-binding transcription factor activity
H8F46_RS10605	COG1279	arginine transmembrane transporter activity
H8F46_RS10610	COG0668	transmembrane transport
H8F46_RS10615	COG3112	Uncharacterised protein family (UPF0231)
H8F46_RS10650	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H8F46_RS10655	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H8F46_RS10660	COG0508	dehydrogenase complex catalyzes the overall conversion of
H8F46_RS10665	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
H8F46_RS10670	COG2186	Transcriptional regulator
H8F46_RS10675	COG3725	Membrane protein required for beta-lactamase induction
H8F46_RS10680	COG3023	N-Acetylmuramoyl-L-alanine amidase
H8F46_RS10685	COG4969	Belongs to the N-Me-Phe pilin family
H8F46_RS10690	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H8F46_RS10695	COG1459	type II secretion system
H8F46_RS10700	COG0237	dephospho-CoA kinase activity
H8F46_RS10705	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
H8F46_RS10710	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
H8F46_RS10715	COG0494	nUDIX hydrolase
H8F46_RS10720	COG0488	(ABC) transporter
H8F46_RS10725	COG0653	protein targeting
H8F46_RS10740	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
H8F46_RS10750	COG0849	cell division
H8F46_RS10755	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
H8F46_RS10760	COG1181	Belongs to the D-alanine--D-alanine ligase family
H8F46_RS10765	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H8F46_RS10770	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H8F46_RS10775	COG0772	Belongs to the SEDS family
H8F46_RS10780	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
H8F46_RS10785	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H8F46_RS10790	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H8F46_RS10795	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H8F46_RS10800	COG0768	penicillin binding
H8F46_RS10805	COG3116	cell division
H8F46_RS10810	COG0275	rRNA processing
H8F46_RS10815	COG2001	Belongs to the MraZ family
H8F46_RS10830	COG0028	Belongs to the TPP enzyme family
H8F46_RS10835	COG1022	Amp-dependent synthetase and ligase
H8F46_RS10855	COG0473	3-isopropylmalate dehydrogenase activity
H8F46_RS10860	COG3066	DNA modification
H8F46_RS10870	COG0242	peptide deformylase activity
H8F46_RS10880	COG0626	cystathionine gamma-synthase activity
H8F46_RS10910	COG3335	DDE superfamily endonuclease
H8F46_RS10920	COG2977	Belongs to the P-Pant transferase superfamily
H8F46_RS10925	COG0010	Belongs to the arginase family
H8F46_RS10930	COG5301	cellulose 1,4-beta-cellobiosidase activity
H8F46_RS10935	COG1166	arginine decarboxylase activity
H8F46_RS10940	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
H8F46_RS10950	COG3091	SprT-like family
H8F46_RS10985	COG3328	transposase activity
H8F46_RS11030	COG1509	lysine 2,3-aminomutase activity
H8F46_RS11035	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
H8F46_RS11040	COG0142	geranyltranstransferase activity
H8F46_RS11050	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H8F46_RS11050	COG0301	tRNA thio-modification
H8F46_RS11055	COG0693	protein deglycase activity
H8F46_RS11060	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
H8F46_RS11065	COG1666	GTP binding
H8F46_RS11070	COG2814	Major facilitator Superfamily
H8F46_RS11075	COG0109	protoheme IX farnesyltransferase activity
H8F46_RS11080	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
H8F46_RS11085	COG1845	cytochrome c oxidase, subunit III
H8F46_RS11090	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H8F46_RS11095	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H8F46_RS11105	COG2223	nitrite transmembrane transporter activity
H8F46_RS11110	COG3056	Lipoprotein
H8F46_RS11115	COG0271	Belongs to the BolA IbaG family
H8F46_RS11120	COG0544	peptidyl-prolyl cis-trans isomerase activity
H8F46_RS11125	COG0740	serine-type endopeptidase activity
H8F46_RS11130	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
H8F46_RS11135	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
H8F46_RS11145	COG0776	regulation of translation
H8F46_RS11150	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H8F46_RS11155	COG1555	photosystem II stabilization
H8F46_RS11160	COG0824	Thioesterase
H8F46_RS11165	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
H8F46_RS11175	COG1522	sequence-specific DNA binding
H8F46_RS11180	COG1132	(ABC) transporter
H8F46_RS11185	COG1132	(ABC) transporter
H8F46_RS11190	COG0347	Belongs to the P(II) protein family
H8F46_RS11195	COG0004	ammonium transporteR
H8F46_RS11200	COG1946	Acyl-CoA thioesterase
H8F46_RS11230	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H8F46_RS11235	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H8F46_RS11240	COG1309	transcriptional regulator
H8F46_RS11245	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
H8F46_RS11250	COG3264	Mechanosensitive ion channel
H8F46_RS11250	COG1196	nuclear chromosome segregation
H8F46_RS11265	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H8F46_RS11280	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H8F46_RS11285	COG0326	Molecular chaperone. Has ATPase activity
H8F46_RS11290	COG0563	adenylate kinase activity
H8F46_RS11295	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H8F46_RS11300	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
H8F46_RS11305	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H8F46_RS11310	COG4651	solute:proton antiporter activity
H8F46_RS11310	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H8F46_RS11315	COG2223	nitrite transmembrane transporter activity
H8F46_RS11320	COG0737	Belongs to the 5'-nucleotidase family
H8F46_RS11340	COG3735	TraB family
H8F46_RS11345	COG2217	Heavy metal translocating P-type atpase
H8F46_RS11355	COG1585	Membrane protein implicated in regulation of membrane protease activity
H8F46_RS11360	COG0330	HflC and HflK could
H8F46_RS11365	COG3118	belongs to the thioredoxin family
H8F46_RS11370	COG0300	oxidoreductase activity
H8F46_RS11375	COG2755	lipolytic protein G-D-S-L family
H8F46_RS11380	COG4181	ATPase activity
H8F46_RS11385	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
H8F46_RS11400	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
H8F46_RS11405	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
H8F46_RS11410	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H8F46_RS11415	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H8F46_RS11420	COG0215	cysteine-tRNA ligase activity
H8F46_RS11460	COG0288	reversible hydration of carbon dioxide
H8F46_RS11465	COG1131	(ABC) transporter
H8F46_RS11470	COG0842	Transport permease protein
H8F46_RS11480	COG0697	spore germination
H8F46_RS11490	COG0656	L-ascorbic acid biosynthetic process
H8F46_RS11495	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
H8F46_RS11500	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
H8F46_RS11505	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H8F46_RS11515	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H8F46_RS11525	COG1489	DNA binding
H8F46_RS11530	COG1643	Atp-dependent helicase
H8F46_RS11535	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H8F46_RS11540	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
H8F46_RS11545	COG0316	Belongs to the HesB IscA family
H8F46_RS11560	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H8F46_RS11565	COG0232	Belongs to the dGTPase family. Type 2 subfamily
H8F46_RS11575	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H8F46_RS11580	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H8F46_RS11585	COG3956	TIGRFAM MazG family protein
H8F46_RS11590	COG0504	CTP synthase activity
H8F46_RS11595	COG0148	phosphopyruvate hydratase activity
H8F46_RS11600	COG0471	metal ion transport
H8F46_RS11615	COG1301	dicarboxylic acid transport
H8F46_RS11630	COG5433	transposase activity
H8F46_RS11635	COG5464	transposase or invertase
H8F46_RS11675	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
H8F46_RS11680	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
H8F46_RS11685	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
H8F46_RS11690	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H8F46_RS11695	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
H8F46_RS11700	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H8F46_RS11700	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H8F46_RS11705	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H8F46_RS11710	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H8F46_RS11720	COG1862	Preprotein translocase
H8F46_RS11730	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
H8F46_RS11735	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
H8F46_RS11740	COG0450	alkyl hydroperoxide reductase
H8F46_RS11755	COG5002	protein histidine kinase activity
H8F46_RS11760	COG0745	RESPONSE REGULATOR receiver
H8F46_RS11765	COG0420	3'-5' exonuclease activity
H8F46_RS11770	COG0419	ATPase involved in DNA repair
H8F46_RS11775	COG0733	neurotransmitter:sodium symporter activity
H8F46_RS11800	COG3719	Belongs to the RNase T2 family
H8F46_RS11820	COG0596	Alpha beta hydrolase
H8F46_RS11880	COG3561	AntA/AntB antirepressor
H8F46_RS11895	COG0582	viral genome integration into host DNA
H8F46_RS11915	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H8F46_RS11920	COG2368	4-hydroxyphenylacetate
H8F46_RS11945	COG3971	2-oxopent-4-enoate hydratase activity
H8F46_RS11960	COG3384	dioxygenase
H8F46_RS11965	COG1012	belongs to the aldehyde dehydrogenase family
H8F46_RS11975	COG0179	Fumarylacetoacetate (FAA) hydrolase
H8F46_RS11980	COG1846	Transcriptional regulator
H8F46_RS11990	COG3423	Transcriptional regulator
H8F46_RS12015	COG3335	DDE superfamily endonuclease
H8F46_RS12095	COG0312	modulator of DNA gyrase
H8F46_RS12100	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H8F46_RS12105	COG3164	Protein of unknown function
H8F46_RS12110	COG1530	ribonuclease E activity
H8F46_RS12115	COG0424	maF-like protein
H8F46_RS12120	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
H8F46_RS12125	COG1792	Involved in formation and maintenance of cell shape
H8F46_RS12130	COG1077	Cell shape determining protein MreB Mrl
H8F46_RS12135	COG0604	alcohol dehydrogenase
H8F46_RS12140	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
H8F46_RS12145	COG0511	ligase activity, forming carbon-carbon bonds
H8F46_RS12150	COG0439	Biotin carboxylase
H8F46_RS12155	COG3924	membrane
H8F46_RS12160	COG4145	pantothenate transmembrane transporter activity
H8F46_RS12165	COG2264	protein methyltransferase activity
H8F46_RS12170	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H8F46_RS12175	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
H8F46_RS12180	COG3423	Transcriptional regulator
H8F46_RS12200	COG3293	Transposase
H8F46_RS12230	COG3335	DDE superfamily endonuclease
H8F46_RS12245	COG1028	Short-chain dehydrogenase reductase Sdr
H8F46_RS12250	COG0697	spore germination
H8F46_RS12275	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H8F46_RS12310	COG0484	heat shock protein binding
H8F46_RS12315	COG0443	Heat shock 70 kDa protein
H8F46_RS12320	COG1584	GPR1 FUN34 yaaH family protein
H8F46_RS12330	COG0521	Mo-molybdopterin cofactor biosynthetic process
H8F46_RS12335	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H8F46_RS12340	COG3022	response to hydroperoxide
H8F46_RS12370	COG1028	Short-chain dehydrogenase reductase Sdr
H8F46_RS12375	COG1535	isochorismatase
H8F46_RS12375	COG3433	isochorismatase activity
H8F46_RS12385	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H8F46_RS12390	COG2814	Major facilitator Superfamily
H8F46_RS12400	COG0083	homoserine kinase activity
H8F46_RS12410	COG0745	RESPONSE REGULATOR receiver
H8F46_RS12420	COG3045	CreA protein
H8F46_RS12425	COG3708	Transcriptional regulator
H8F46_RS12425	COG2207	Transcriptional regulator
H8F46_RS12430	COG0406	alpha-ribazole phosphatase activity
H8F46_RS12435	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
H8F46_RS12440	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
H8F46_RS12445	COG0741	lytic transglycosylase activity
H8F46_RS12455	COG0488	(ABC) transporter
H8F46_RS12480	COG0410	ABC transporter
H8F46_RS12490	COG4177	L-phenylalanine transmembrane transporter activity
H8F46_RS12495	COG0559	Belongs to the binding-protein-dependent transport system permease family
H8F46_RS12505	COG1929	Belongs to the glycerate kinase type-1 family
H8F46_RS12515	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H8F46_RS12520	COG2177	Part of the ABC transporter FtsEX involved in
H8F46_RS12525	COG2884	Cell division ATP-binding protein ftsE
H8F46_RS12530	COG0552	protein localization to endoplasmic reticulum
H8F46_RS12535	COG0742	ribosomal rna small subunit methyltransferase
H8F46_RS12540	COG3776	membrane
H8F46_RS12545	COG3714	YhhN family
H8F46_RS12555	COG0425	Belongs to the sulfur carrier protein TusA family
H8F46_RS12560	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
H8F46_RS12590	COG2271	Major facilitator Superfamily
H8F46_RS12595	COG0584	glycerophosphoryl diester phosphodiesterase
H8F46_RS12600	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
H8F46_RS12610	COG1053	succinate dehydrogenase
H8F46_RS12615	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H8F46_RS12620	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
H8F46_RS12625	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
H8F46_RS12630	COG4771	TonB-dependent receptor
H8F46_RS12635	COG4770	biotin carboxylase activity
H8F46_RS12645	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
H8F46_RS12680	COG0138	bifunctional purine biosynthesis protein purh
H8F46_RS12685	COG0151	Belongs to the GarS family
H8F46_RS12705	COG1515	deoxyribonuclease V activity
H8F46_RS12710	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
H8F46_RS12715	COG0339	signal peptide processing
H8F46_RS12720	COG2816	NAD+ diphosphatase activity
H8F46_RS12745	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
H8F46_RS12750	COG0352	thiamine-phosphate diphosphorylase activity
H8F46_RS12755	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H8F46_RS12760	COG2104	thiamine diphosphate biosynthetic process
H8F46_RS12765	COG2022	thiamine diphosphate biosynthetic process
H8F46_RS12780	COG3436	PFAM IS66 Orf2 family protein
H8F46_RS12785	COG4372	Transposase
H8F46_RS12790	COG0543	2 iron, 2 sulfur cluster binding
H8F46_RS12790	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H8F46_RS12800	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H8F46_RS12805	COG0765	amino acid transport
H8F46_RS12810	COG1126	abc transporter atp-binding protein
H8F46_RS12815	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H8F46_RS12835	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H8F46_RS12850	COG1012	belongs to the aldehyde dehydrogenase family
H8F46_RS12855	COG4638	Rieske (2fe-2S)
H8F46_RS12860	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H8F46_RS12870	COG0583	DNA-binding transcription factor activity
H8F46_RS12890	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
H8F46_RS12895	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
H8F46_RS12910	COG2515	1-aminocyclopropane-1-carboxylate deaminase
H8F46_RS12915	COG1280	lysine exporter protein (LysE YggA)
H8F46_RS12920	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
H8F46_RS12930	COG0864	Transcriptional regulator
H8F46_RS12935	COG1690	Belongs to the RtcB family
H8F46_RS12995	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
H8F46_RS13010	COG0602	queuosine metabolic process
H8F46_RS13015	COG3787	Belongs to the UPF0306 family
H8F46_RS13030	COG3153	acetyltransferase
H8F46_RS13035	COG3154	lipid carrier protein
H8F46_RS13040	COG1470	cell adhesion involved in biofilm formation
H8F46_RS13040	COG1388	LysM domain
H8F46_RS13045	COG3275	phosphorelay sensor kinase activity
H8F46_RS13055	COG0513	Belongs to the DEAD box helicase family
H8F46_RS13070	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
H8F46_RS13075	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H8F46_RS13080	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
H8F46_RS13085	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
H8F46_RS13090	COG0195	Participates in both transcription termination and antitermination
H8F46_RS13095	COG0779	Required for maturation of 30S ribosomal subunits
H8F46_RS13110	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H8F46_RS13115	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H8F46_RS13120	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H8F46_RS13130	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
H8F46_RS13135	COG1534	Rna-binding protein
H8F46_RS13145	COG2027	D-alanyl-D-alanine carboxypeptidase
H8F46_RS13150	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
H8F46_RS13155	COG0211	Belongs to the bacterial ribosomal protein bL27 family
H8F46_RS13160	COG0261	This protein binds to 23S rRNA in the presence of protein L20
H8F46_RS13165	COG0142	geranyltranstransferase activity
H8F46_RS13180	COG3423	Transcriptional regulator
H8F46_RS13185	COG0039	L-malate dehydrogenase activity
H8F46_RS13195	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H8F46_RS13200	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
H8F46_RS13210	COG2105	PFAM AIG2 family protein
H8F46_RS13220	COG0729	surface antigen
H8F46_RS13225	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H8F46_RS13230	COG1253	flavin adenine dinucleotide binding
H8F46_RS13240	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
H8F46_RS13250	COG2337	Toxic component of a toxin-antitoxin (TA) module
H8F46_RS13260	COG0545	Peptidyl-prolyl cis-trans isomerase
H8F46_RS13280	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
H8F46_RS13285	COG2965	DNA replication, synthesis of RNA primer
H8F46_RS13290	COG0360	Binds together with S18 to 16S ribosomal RNA
H8F46_RS13295	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H8F46_RS13300	COG0557	exoribonuclease II activity
H8F46_RS13305	COG1959	2 iron, 2 sulfur cluster binding
H8F46_RS13310	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H8F46_RS13315	COG0330	HflC and HflK could
H8F46_RS13320	COG0330	HflC and HflK could
H8F46_RS13325	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H8F46_RS13330	COG1923	regulation of RNA biosynthetic process
H8F46_RS13335	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
H8F46_RS13340	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H8F46_RS13345	COG0860	N-Acetylmuramoyl-L-alanine amidase
H8F46_RS13350	COG0802	atpase or kinase
H8F46_RS13355	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H8F46_RS13360	COG2368	4-hydroxyphenylacetate
H8F46_RS13365	COG2368	4-hydroxyphenylacetate
H8F46_RS13370	COG1960	acyl-CoA dehydrogenase activity
H8F46_RS13375	COG3033	Beta-eliminating lyase
H8F46_RS13385	COG0477	Major facilitator Superfamily
H8F46_RS13390	COG0583	DNA-binding transcription factor activity
H8F46_RS13420	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
H8F46_RS13425	COG1162	GTPase activity
H8F46_RS13430	COG0688	phosphatidylethanolamine metabolic process
H8F46_RS13435	COG1511	domain protein
H8F46_RS13435	COG3264	Mechanosensitive ion channel
H8F46_RS13450	COG3152	Membrane
H8F46_RS13455	COG1609	Transcriptional regulator
H8F46_RS13460	COG0477	Major facilitator Superfamily
H8F46_RS13465	COG0561	phosphatase activity
H8F46_RS13470	COG2267	carboxylic ester hydrolase activity
H8F46_RS13475	COG0514	ATP-dependent DNA helicase (RecQ)
H8F46_RS13485	COG2050	protein possibly involved in aromatic compounds catabolism
H8F46_RS13510	COG0598	Magnesium transport protein CorA
H8F46_RS13515	COG0210	DNA helicase
H8F46_RS13520	COG1011	Hydrolase
H8F46_RS13525	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
H8F46_RS13530	COG3159	Protein conserved in bacteria
H8F46_RS13535	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
H8F46_RS13545	COG1965	Belongs to the frataxin family
H8F46_RS13555	COG0181	hydroxymethylbilane synthase activity
H8F46_RS13565	COG2959	enzyme of heme biosynthesis
H8F46_RS13570	COG3071	HemY protein
H8F46_RS13600	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
H8F46_RS13610	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H8F46_RS13615	COG2244	polysaccharide biosynthetic process
H8F46_RS13620	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H8F46_RS13625	COG0456	acetyltransferase
H8F46_RS13630	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
H8F46_RS13635	COG1088	dTDP-glucose 4,6-dehydratase activity
H8F46_RS13640	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
H8F46_RS13645	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
H8F46_RS13650	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
H8F46_RS13655	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H8F46_RS13660	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
H8F46_RS13665	COG3118	belongs to the thioredoxin family
H8F46_RS13670	COG0513	Belongs to the DEAD box helicase family
H8F46_RS13675	COG0248	Ppx GppA phosphatase
H8F46_RS13680	COG0210	DNA helicase
H8F46_RS13690	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
H8F46_RS13715	COG0129	dihydroxy-acid dehydratase activity
H8F46_RS13720	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H8F46_RS13725	COG3978	acetolactate synthase activity
H8F46_RS13745	COG3085	chromosome segregation
H8F46_RS13750	COG0583	DNA-binding transcription factor activity
H8F46_RS13790	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
H8F46_RS13800	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H8F46_RS13805	COG0009	L-threonylcarbamoyladenylate synthase
H8F46_RS13810	COG0551	DNA topoisomerase type I activity
H8F46_RS13815	COG0758	DNA mediated transformation
H8F46_RS13820	COG0242	peptide deformylase activity
H8F46_RS13825	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H8F46_RS13830	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H8F46_RS13830	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H8F46_RS13835	COG0569	domain protein
H8F46_RS13840	COG3036	rescue of stalled ribosome
H8F46_RS13845	COG0789	Transcriptional regulator
H8F46_RS13850	COG0203	ribosomal protein L17
H8F46_RS13855	COG0202	RNA polymerase activity
H8F46_RS13860	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
H8F46_RS13870	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
H8F46_RS13875	COG0257	Belongs to the bacterial ribosomal protein bL36 family
H8F46_RS13880	COG0201	protein transport
H8F46_RS13885	COG0200	Binds to the 23S rRNA
H8F46_RS13890	COG1841	ribosomal large subunit assembly
H8F46_RS13895	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
H8F46_RS13900	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
H8F46_RS13905	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
H8F46_RS13910	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
H8F46_RS13915	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
H8F46_RS13920	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
H8F46_RS13925	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
H8F46_RS13930	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
H8F46_RS13935	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
H8F46_RS13945	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
H8F46_RS13960	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
H8F46_RS13965	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
H8F46_RS13975	COG0088	Forms part of the polypeptide exit tunnel
H8F46_RS13980	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
H8F46_RS13985	COG0051	transcription antitermination factor activity, RNA binding
H8F46_RS13990	COG5433	transposase activity
H8F46_RS14010	COG3344	reverse transcriptase
H8F46_RS14030	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H8F46_RS14065	COG1072	(Pantothenic acid kinase))
H8F46_RS14075	COG0812	UDP-N-acetylmuramate dehydrogenase activity
H8F46_RS14110	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H8F46_RS14115	COG4206	TonB-dependent receptor
H8F46_RS14120	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H8F46_RS14135	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H8F46_RS14145	COG0165	Argininosuccinate lyase
H8F46_RS14150	COG0137	argininosuccinate synthase activity
H8F46_RS14160	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
H8F46_RS14165	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H8F46_RS14170	COG1598	PFAM Uncharacterised protein family UPF0150
H8F46_RS14190	COG3077	Addiction module antitoxin, RelB DinJ family
H8F46_RS14210	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
H8F46_RS14215	COG0527	aspartate kinase activity
H8F46_RS14215	COG0460	homoserine dehydrogenase
H8F46_RS14220	COG0626	cystathionine gamma-synthase activity
H8F46_RS14225	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
H8F46_RS14235	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H8F46_RS14240	COG1609	Transcriptional regulator
H8F46_RS14245	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H8F46_RS14250	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
H8F46_RS14255	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
H8F46_RS14260	COG1575	Belongs to the MenA family. Type 1 subfamily
H8F46_RS14265	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H8F46_RS14270	COG3074	FtsZ-dependent cytokinesis
H8F46_RS14280	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H8F46_RS14285	COG2814	Major facilitator Superfamily
H8F46_RS14295	COG3152	Membrane
H8F46_RS14305	COG0149	triose-phosphate isomerase activity
H8F46_RS14335	COG3645	SOS response
H8F46_RS14395	COG1561	YicC-like family, N-terminal region
H8F46_RS14400	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
H8F46_RS14405	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
H8F46_RS14410	COG1309	transcriptional regulator
H8F46_RS14415	COG0756	dUTP diphosphatase activity
H8F46_RS14420	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H8F46_RS14425	COG2003	Belongs to the UPF0758 family
H8F46_RS14435	COG0267	Belongs to the bacterial ribosomal protein bL33 family
H8F46_RS14440	COG0438	transferase activity, transferring glycosyl groups
H8F46_RS14450	COG0438	transferase activity, transferring glycosyl groups
H8F46_RS14465	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H8F46_RS14470	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
H8F46_RS14480	COG1519	Transferase
H8F46_RS14485	COG0859	PFAM glycosyl transferase family 9
H8F46_RS14495	COG0438	transferase activity, transferring glycosyl groups
H8F46_RS14525	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H8F46_RS14530	COG0156	8-amino-7-oxononanoate synthase activity
H8F46_RS14535	COG1063	alcohol dehydrogenase
H8F46_RS14540	COG2861	carbohydrate metabolic process
H8F46_RS14545	COG4942	peptidase
H8F46_RS14555	COG3657	addiction module killer protein
H8F46_RS14560	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H8F46_RS14565	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
H8F46_RS14570	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
H8F46_RS14575	COG1045	serine acetyltransferase
H8F46_RS14580	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H8F46_RS14620	COG3293	Transposase
H8F46_RS14640	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H8F46_RS14645	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H8F46_RS14760	COG0673	inositol 2-dehydrogenase activity
H8F46_RS14770	COG2205	protein histidine kinase activity
H8F46_RS14775	COG0745	RESPONSE REGULATOR receiver
H8F46_RS14780	COG3678	ATP-independent chaperone mediated protein folding
H8F46_RS14790	COG1724	mRNA binding
H8F46_RS14795	COG1598	PFAM Uncharacterised protein family UPF0150
H8F46_RS14805	COG2944	sequence-specific DNA binding
H8F46_RS14815	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
H8F46_RS14820	COG0205	6-phosphofructokinase activity
H8F46_RS14825	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
H8F46_RS14830	COG3177	Filamentation induced by cAMP protein fic
H8F46_RS14845	COG3609	addiction module antidote protein, CC2985 family
H8F46_RS14850	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H8F46_RS14860	COG2188	Transcriptional regulator
H8F46_RS14865	COG1368	sulfuric ester hydrolase activity
H8F46_RS14870	COG3058	Necessary for formate dehydrogenase activity
H8F46_RS14890	COG2864	formate dehydrogenase
H8F46_RS14900	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
H8F46_RS14925	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
H8F46_RS14930	COG2249	NAD(P)H dehydrogenase (quinone) activity
H8F46_RS14945	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
H8F46_RS14965	COG4796	Type ii and iii secretion system protein
H8F46_RS14970	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
H8F46_RS14975	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
H8F46_RS14980	COG3266	domain, Protein
H8F46_RS14990	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H8F46_RS14995	COG0546	phosphoglycolate phosphatase activity
H8F46_RS15000	COG0180	Tryptophanyl-tRNA synthetase
H8F46_RS15005	COG2258	MOSC domain
H8F46_RS15010	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H8F46_RS15015	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H8F46_RS15020	COG3162	membrane
H8F46_RS15025	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H8F46_RS15050	COG0477	Major facilitator Superfamily
H8F46_RS15055	COG1609	Transcriptional regulator
H8F46_RS15060	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H8F46_RS15075	COG0714	Associated with various cellular activities
H8F46_RS15080	COG2425	protein containing a von Willebrand factor type A (vWA) domain
H8F46_RS15085	COG2502	aspartate--ammonia ligase
H8F46_RS15090	COG1522	sequence-specific DNA binding
H8F46_RS15095	COG0716	FMN binding
H8F46_RS15100	COG0445	tRNA wobble uridine modification
H8F46_RS15105	COG0357	Ribosomal RNA small subunit methyltransferase G
H8F46_RS15110	COG3312	ion transport
H8F46_RS15115	COG0356	it plays a direct role in the translocation of protons across the membrane
H8F46_RS15125	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H8F46_RS15130	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H8F46_RS15135	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
H8F46_RS15140	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
H8F46_RS15145	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
H8F46_RS15150	COG0355	proton-transporting ATP synthase activity, rotational mechanism
H8F46_RS15155	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H8F46_RS15160	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H8F46_RS15170	COG0732	type I restriction modification DNA specificity domain
H8F46_RS15175	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
H8F46_RS15205	COG0257	Belongs to the bacterial ribosomal protein bL36 family
H8F46_RS15210	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H8F46_RS15225	COG0187	DNA topoisomerase II activity
H8F46_RS15230	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H8F46_RS15235	COG0592	DNA-directed DNA polymerase activity
H8F46_RS15245	COG0230	Belongs to the bacterial ribosomal protein bL34 family
H8F46_RS15250	COG0594	ribonuclease P activity
H8F46_RS15255	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
H8F46_RS15260	COG0706	membrane insertase activity
H8F46_RS15265	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
H8F46_RS15270	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H8F46_RS15295	COG3038	cytochrome b561
H8F46_RS15325	COG3327	negative regulation of DNA-templated transcription, initiation
H8F46_RS15340	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
H8F46_RS15345	COG0183	Belongs to the thiolase family
H8F46_RS15350	COG2050	protein possibly involved in aromatic compounds catabolism
H8F46_RS15355	COG1250	3-hydroxyacyl-CoA dehydrogenase
H8F46_RS15360	COG1024	Enoyl-CoA hydratase
H8F46_RS15365	COG1024	Enoyl-CoA hydratase
H8F46_RS15370	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H8F46_RS15375	COG2151	metal-sulfur cluster biosynthetic enzyme
H8F46_RS15380	COG3396	Phenylacetate-CoA oxygenase
H8F46_RS15385	COG3460	Phenylacetate-CoA oxygenase
H8F46_RS15390	COG3396	Phenylacetate-CoA oxygenase
H8F46_RS15395	COG2030	dehydratase
H8F46_RS15395	COG1012	belongs to the aldehyde dehydrogenase family
H8F46_RS15400	COG4680	protein conserved in bacteria
H8F46_RS15405	COG5499	transcription regulator containing HTH domain
H8F46_RS15425	COG0306	phosphate transporter
H8F46_RS15430	COG2081	HI0933 family
H8F46_RS15465	COG1741	Belongs to the pirin family
H8F46_RS15470	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
H8F46_RS15475	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
H8F46_RS15480	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
H8F46_RS15490	COG0494	nUDIX hydrolase
H8F46_RS15500	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H8F46_RS15500	COG1263	PTS System
H8F46_RS15505	COG0366	Alpha amylase catalytic
H8F46_RS15545	COG1028	Short-chain dehydrogenase reductase Sdr
H8F46_RS15555	COG3344	reverse transcriptase
H8F46_RS15605	COG1942	4-Oxalocrotonate Tautomerase
H8F46_RS15610	COG1295	ribonuclease BN
H8F46_RS15730	COG3335	DDE superfamily endonuclease
H8F46_RS15760	COG3335	DDE superfamily endonuclease
H8F46_RS15795	COG2204	response regulator
H8F46_RS15810	COG3078	GTPase activator activity
H8F46_RS15850	COG3157	Type VI secretion system effector, Hcp
H8F46_RS15855	COG0765	amino acid transport
H8F46_RS15860	COG0765	amino acid transport
H8F46_RS15865	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H8F46_RS15870	COG0704	Plays a role in the regulation of phosphate uptake
H8F46_RS15875	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H8F46_RS15880	COG0581	inorganic phosphate transmembrane transporter activity
H8F46_RS15885	COG0573	inorganic phosphate transmembrane transporter activity
H8F46_RS15890	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H8F46_RS15905	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H8F46_RS15910	COG2183	response to ionizing radiation
H8F46_RS15920	COG1918	ferrous iron import across plasma membrane
H8F46_RS15940	COG0339	signal peptide processing
H8F46_RS15945	COG0742	ribosomal rna small subunit methyltransferase
H8F46_RS15955	COG0589	response to stress
H8F46_RS15970	COG0626	cystathionine gamma-synthase activity
H8F46_RS15985	COG1735	metal-dependent hydrolase with the TIM-barrel fold
H8F46_RS15990	COG3457	Alanine racemase
H8F46_RS16000	COG2188	Transcriptional regulator
H8F46_RS16005	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H8F46_RS16015	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
H8F46_RS16020	COG1349	DNA-binding transcription factor activity
H8F46_RS16025	COG0705	Rhomboid family
H8F46_RS16030	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H8F46_RS16035	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
H8F46_RS16035	COG0316	Belongs to the HesB IscA family
H8F46_RS16045	COG0596	Alpha beta hydrolase
H8F46_RS16065	COG0612	Peptidase, M16
H8F46_RS16070	COG0675	Transposase, IS605 OrfB family
H8F46_RS16080	COG2199	diguanylate cyclase activity
H8F46_RS16080	COG2200	EAL domain
H8F46_RS16085	COG4608	Belongs to the ABC transporter superfamily
H8F46_RS16090	COG0444	Belongs to the ABC transporter superfamily
H8F46_RS16095	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H8F46_RS16100	COG0601	transmembrane transport
H8F46_RS16105	COG0747	negative chemotaxis
H8F46_RS16120	COG0751	glycine-tRNA ligase activity
H8F46_RS16125	COG0752	glycyl-tRNA synthetase alpha subunit
H8F46_RS16130	COG2818	Glycosylase
H8F46_RS16135	COG3977	Valine--pyruvate aminotransferase
H8F46_RS16145	COG0641	radical SAM
H8F46_RS16155	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H8F46_RS16165	COG5645	(Lipo)protein
H8F46_RS16170	COG0823	Involved in the tonB-independent uptake of proteins
H8F46_RS16175	COG2860	membrane
H8F46_RS16180	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H8F46_RS16185	COG0194	GDP metabolic process
H8F46_RS16195	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H8F46_RS16200	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H8F46_RS16205	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H8F46_RS16210	COG0786	glutamate:sodium symporter activity
H8F46_RS16215	COG2233	PERMEase
H8F46_RS16220	COG2982	Protein involved in outer membrane biogenesis
H8F46_RS16225	COG0456	acetyltransferase
H8F46_RS16230	COG1490	D-aminoacyl-tRNA deacylase activity
H8F46_RS16280	COG3344	reverse transcriptase
H8F46_RS16340	COG0726	polysaccharide deacetylase
H8F46_RS16345	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H8F46_RS16350	COG0085	RNA polymerase activity
H8F46_RS16355	COG0222	ribosome binding
H8F46_RS16360	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
H8F46_RS16365	COG0081	regulation of translation
H8F46_RS16370	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
H8F46_RS16375	COG0250	Participates in transcription elongation, termination and antitermination
H8F46_RS16385	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H8F46_RS16390	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H8F46_RS16395	COG0049	tRNA binding
H8F46_RS16400	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
H8F46_RS16405	COG2168	tRNA wobble position uridine thiolation
H8F46_RS16410	COG2923	Belongs to the DsrF TusC family
H8F46_RS16415	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
H8F46_RS16420	COG2964	Protein conserved in bacteria
H8F46_RS16425	COG0545	Peptidyl-prolyl cis-trans isomerase
H8F46_RS16430	COG2900	Belongs to the SlyX family
H8F46_RS16445	COG0483	inositol monophosphate 1-phosphatase activity
H8F46_RS16450	COG2813	Specifically methylates the guanine in position
H8F46_RS16465	COG2234	aminopeptidase activity
H8F46_RS16475	COG1047	Peptidyl-prolyl cis-trans
H8F46_RS16480	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
H8F46_RS16490	COG2249	NAD(P)H dehydrogenase (quinone) activity
H8F46_RS16495	COG0488	(ABC) transporter
H8F46_RS16505	COG0583	DNA-binding transcription factor activity
H8F46_RS16510	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
H8F46_RS16515	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H8F46_RS16515	COG1263	PTS System
H8F46_RS16520	COG1280	lysine exporter protein (LysE YggA)
H8F46_RS16525	COG0429	hydrolase of the alpha beta-hydrolase fold
H8F46_RS16530	COG3089	Belongs to the UPF0270 family
H8F46_RS16535	COG3954	Phosphoribulokinase
H8F46_RS16540	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H8F46_RS16545	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H8F46_RS16555	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H8F46_RS16560	COG0218	Necessary for normal cell division and for the maintenance of normal septation
H8F46_RS16565	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H8F46_RS16565	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H8F46_RS16570	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H8F46_RS16575	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
H8F46_RS16585	COG1763	Mo-molybdopterin cofactor biosynthetic process
H8F46_RS16590	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
H8F46_RS16595	COG1830	Aldolase
H8F46_RS16600	COG1879	ABC-type sugar transport system periplasmic component
H8F46_RS16605	COG1070	Carbohydrate kinase
H8F46_RS16630	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
H8F46_RS16635	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H8F46_RS16700	COG3335	DDE superfamily endonuclease
H8F46_RS16725	COG4580	involved in the transport of maltose and maltodextrins
H8F46_RS16730	COG3842	ATPase activity
H8F46_RS16735	COG2182	Extracellular solute-binding protein
H8F46_RS16740	COG1175	transmembrane transport
H8F46_RS16745	COG3833	ABC-type maltose transport systems, permease component
H8F46_RS16750	COG1640	4-alpha-glucanotransferase
H8F46_RS16755	COG0058	SHG alpha-glucan phosphorylase activity
H8F46_RS16760	COG2909	trisaccharide binding
H8F46_RS16770	COG1063	alcohol dehydrogenase
H8F46_RS16775	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H8F46_RS16780	COG2223	nitrite transmembrane transporter activity
H8F46_RS16795	COG4372	Transposase
H8F46_RS16800	COG3436	PFAM IS66 Orf2 family protein
H8F46_RS16825	COG0525	valine-tRNA ligase activity
H8F46_RS16830	COG2927	DNA polymerase III (CHI subunit)
H8F46_RS16835	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H8F46_RS16840	COG0795	lipopolysaccharide-transporting ATPase activity
H8F46_RS16845	COG0795	lipopolysaccharide-transporting ATPase activity
H8F46_RS16850	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H8F46_RS16860	COG0582	viral genome integration into host DNA
H8F46_RS16870	COG2801	Transposase and inactivated derivatives
H8F46_RS16905	COG0402	S-adenosylhomocysteine deaminase activity
H8F46_RS16920	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H8F46_RS16925	COG3293	Transposase
H8F46_RS16940	COG1396	sequence-specific DNA binding
H8F46_RS16945	COG3550	peptidyl-serine autophosphorylation
H8F46_RS16950	COG1301	dicarboxylic acid transport
H8F46_RS16955	COG0583	DNA-binding transcription factor activity
H8F46_RS16960	COG1794	racemase activity, acting on amino acids and derivatives
H8F46_RS16965	COG3586	endonuclease activity
H8F46_RS17005	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
H8F46_RS17010	COG3328	transposase activity
H8F46_RS17025	COG3028	Belongs to the UPF0307 family
H8F46_RS17030	COG0312	modulator of DNA gyrase
H8F46_RS17050	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H8F46_RS17070	COG3676	manually curated
H8F46_RS17085	COG0583	DNA-binding transcription factor activity
H8F46_RS17095	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H8F46_RS17100	COG1660	Displays ATPase and GTPase activities
H8F46_RS17110	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
H8F46_RS17115	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
H8F46_RS17120	COG1137	ATPase activity
H8F46_RS17125	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
H8F46_RS17130	COG3117	lipopolysaccharide transmembrane transporter activity
H8F46_RS17135	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
H8F46_RS17140	COG0517	IMP dehydrogenase activity
H8F46_RS17140	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
H8F46_RS17145	COG0530	calcium, potassium:sodium antiporter activity
H8F46_RS17150	COG1127	ABC transporter
H8F46_RS17155	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H8F46_RS17160	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H8F46_RS17165	COG2854	intermembrane phospholipid transfer
H8F46_RS17170	COG3113	response to antibiotic
H8F46_RS17175	COG5007	Belongs to the BolA IbaG family
H8F46_RS17180	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H8F46_RS17185	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H8F46_RS17190	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H8F46_RS17195	COG3105	Protein conserved in bacteria
H8F46_RS17200	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
H8F46_RS17205	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
H8F46_RS17210	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H8F46_RS17215	COG0625	glutathione transferase activity
H8F46_RS17220	COG2969	positive regulation of protein catabolic process
H8F46_RS17230	COG0493	'glutamate synthase
H8F46_RS17235	COG0067	glutamate synthase
H8F46_RS17235	COG0069	glutamate synthase activity
H8F46_RS17235	COG0070	glutamate synthase
H8F46_RS17240	COG0784	Response regulator, receiver
H8F46_RS17240	COG2198	Histidine kinase
H8F46_RS17240	COG5002	protein histidine kinase activity
H8F46_RS17245	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
H8F46_RS17250	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H8F46_RS17265	COG2823	Periplasmic or secreted lipoprotein
H8F46_RS17270	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
H8F46_RS17275	COG0792	nuclease activity
H8F46_RS17285	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
H8F46_RS17300	COG1741	Belongs to the pirin family
H8F46_RS17305	COG0583	DNA-binding transcription factor activity
H8F46_RS17310	COG2259	Doxx family
H8F46_RS17320	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
H8F46_RS17325	COG4575	ribosome binding
H8F46_RS17330	COG0586	Pfam SNARE associated Golgi protein
H8F46_RS17335	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
H8F46_RS17340	COG1902	pentaerythritol trinitrate reductase activity
H8F46_RS17340	COG0446	pyridine nucleotide-disulphide oxidoreductase
H8F46_RS17350	COG2990	Protein conserved in bacteria
H8F46_RS17360	COG0477	Major facilitator Superfamily
H8F46_RS17475	COG5433	transposase activity
H8F46_RS17530	COG1802	Transcriptional regulator
H8F46_RS17530	COG4626	Terminase
H8F46_RS17545	COG3423	Transcriptional regulator
H8F46_RS17565	COG0358	DNA primase activity
H8F46_RS17570	COG0828	Belongs to the bacterial ribosomal protein bS21 family
H8F46_RS17575	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
H8F46_RS17585	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
H8F46_RS17590	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
H8F46_RS17600	COG4991	sh3 domain protein
H8F46_RS17605	COG3025	triphosphatase activity
H8F46_RS17610	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
H8F46_RS17615	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
H8F46_RS17615	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
H8F46_RS17625	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H8F46_RS17630	COG3384	dioxygenase
H8F46_RS17635	COG0754	glutathionylspermidine amidase activity
H8F46_RS17640	COG5463	Belongs to the UPF0441 family
H8F46_RS17645	COG1538	Outer membrane efflux protein
H8F46_RS17650	COG0494	nUDIX hydrolase
H8F46_RS17655	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
H8F46_RS17660	COG3150	esterase
H8F46_RS17670	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
H8F46_RS17675	COG0204	Acyl-transferase
H8F46_RS17680	COG2132	Multicopper oxidase
H8F46_RS17690	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H8F46_RS17695	COG2967	ApaG domain
H8F46_RS17700	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H8F46_RS17705	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
H8F46_RS17710	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H8F46_RS17715	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
H8F46_RS17720	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
H8F46_RS17725	COG0564	pseudouridine synthase activity
H8F46_RS17730	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H8F46_RS17745	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
H8F46_RS17750	COG1178	ABC-type Fe3 transport system permease component
H8F46_RS17755	COG4143	(ABC) transporter
H8F46_RS17760	COG0494	nUDIX hydrolase
H8F46_RS17770	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
H8F46_RS17775	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
H8F46_RS17790	COG2175	clavaminate synthase activity
H8F46_RS17795	COG2165	general secretion pathway protein
H8F46_RS17800	COG4795	General secretion pathway protein
H8F46_RS17815	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
H8F46_RS17825	COG1074	ATP-dependent DNA helicase activity
H8F46_RS17830	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H8F46_RS17840	COG0860	N-Acetylmuramoyl-L-alanine amidase
H8F46_RS17860	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
H8F46_RS17865	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
H8F46_RS17870	COG2166	iron-sulfur cluster assembly
H8F46_RS17875	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H8F46_RS17880	COG0583	DNA-binding transcription factor activity
H8F46_RS17885	COG2363	Small membrane protein
H8F46_RS17890	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
H8F46_RS17920	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H8F46_RS17930	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
H8F46_RS17930	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
H8F46_RS17945	COG3098	single-species biofilm formation
H8F46_RS17950	COG0564	pseudouridine synthase activity
H8F46_RS17990	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
H8F46_RS18000	COG0052	Belongs to the universal ribosomal protein uS2 family
H8F46_RS18005	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
H8F46_RS18010	COG0528	UMP kinase activity
H8F46_RS18015	COG0233	cytoplasmic translational termination
H8F46_RS18020	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
H8F46_RS18025	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H8F46_RS18030	COG0575	Belongs to the CDS family
H8F46_RS18035	COG0750	zinc metalloprotease
H8F46_RS18040	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H8F46_RS18050	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H8F46_RS18055	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H8F46_RS18060	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H8F46_RS18065	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H8F46_RS18070	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H8F46_RS18080	COG0825	malonyl-CoA metabolic process
H8F46_RS18085	COG0037	tRNA processing
H8F46_RS18090	COG4568	rho-dependent transcription termination
H8F46_RS18095	COG3015	lipoprotein NlpE involved in copper resistance
H8F46_RS18100	COG0442	prolyl-tRNA aminoacylation
H8F46_RS18105	COG1720	tRNA m6t6A37 methyltransferase activity
H8F46_RS18115	COG1464	Belongs to the NlpA lipoprotein family
H8F46_RS18125	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H8F46_RS18130	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
H8F46_RS18160	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
H8F46_RS18165	COG3423	Transcriptional regulator
H8F46_RS18170	COG1802	Transcriptional regulator
H8F46_RS18170	COG4626	Terminase
H8F46_RS18250	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
H8F46_RS18255	COG2224	Isocitrate lyase
H8F46_RS18260	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
H8F46_RS18270	COG0800	Aldolase
H8F46_RS18275	COG1414	Transcriptional regulator
H8F46_RS18290	COG0527	aspartate kinase activity
H8F46_RS18295	COG0166	Belongs to the GPI family
H8F46_RS18300	COG3161	chorismate lyase activity
H8F46_RS18305	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
H8F46_RS18310	COG2937	Belongs to the GPAT DAPAT family
H8F46_RS18315	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
H8F46_RS18325	COG0735	belongs to the Fur family
H8F46_RS18345	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
H8F46_RS18360	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H8F46_RS18380	COG1448	Aminotransferase
H8F46_RS18420	COG0837	glucose binding
H8F46_RS18425	COG2146	nitrite reductase [NAD(P)H] activity
H8F46_RS18430	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H8F46_RS18465	COG2252	PERMEase
H8F46_RS18485	COG2366	antibiotic biosynthetic process
H8F46_RS18490	COG0025	NhaP-type Na H and K H
H8F46_RS18500	COG0583	DNA-binding transcription factor activity
H8F46_RS18505	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
H8F46_RS18515	COG2610	gluconate transmembrane transporter activity
H8F46_RS18520	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
H8F46_RS18530	COG0586	Pfam SNARE associated Golgi protein
H8F46_RS18535	COG2226	methyltransferase
H8F46_RS18540	COG3165	ubiquinone biosynthetic process from chorismate
H8F46_RS18545	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H8F46_RS18550	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H8F46_RS18555	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H8F46_RS18560	COG0805	protein transport
H8F46_RS18575	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
H8F46_RS18585	COG0183	Belongs to the thiolase family
H8F46_RS18590	COG1024	Enoyl-CoA hydratase
H8F46_RS18590	COG1250	3-hydroxyacyl-CoA dehydrogenase
H8F46_RS18595	COG0006	proline dipeptidase activity
H8F46_RS18600	COG1739	Uncharacterized protein family UPF0029
H8F46_RS18610	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
H8F46_RS18645	COG3021	interspecies interaction between organisms
H8F46_RS18655	COG0602	queuosine metabolic process
H8F46_RS18660	COG0720	synthase
H8F46_RS18665	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H8F46_RS18670	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H8F46_RS18675	COG0175	sulfate reduction
H8F46_RS18680	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H8F46_RS18680	COG1648	precorrin-2 dehydrogenase activity
H8F46_RS18685	COG0175	sulfate reduction
H8F46_RS18690	COG2895	sulfate adenylyltransferase (ATP) activity
H8F46_RS18695	COG0529	Catalyzes the synthesis of activated sulfate
H8F46_RS18700	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
H8F46_RS18705	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
H8F46_RS18710	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
H8F46_RS18715	COG0585	pseudouridine synthase activity
H8F46_RS18720	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
H8F46_RS18725	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H8F46_RS18730	COG1388	LysM domain
H8F46_RS18730	COG4942	peptidase
H8F46_RS18745	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
H8F46_RS18760	COG1966	Carbon starvation protein
H8F46_RS18765	COG2879	small protein
H8F46_RS18770	COG0523	cobalamin synthesis protein
H8F46_RS18775	COG0582	viral genome integration into host DNA
H8F46_RS18785	COG0814	amino acid
H8F46_RS18795	COG3091	SprT-like family
H8F46_RS18810	COG0657	acetylesterase activity
H8F46_RS18875	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
H8F46_RS18885	COG4667	esterase of the alpha-beta hydrolase superfamily
H8F46_RS18890	COG0084	hydrolase, TatD family'
H8F46_RS18895	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H8F46_RS18900	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
H8F46_RS18905	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
H8F46_RS18910	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
H8F46_RS18915	COG0813	purine-nucleoside phosphorylase activity
H8F46_RS18925	COG3188	usher protein
H8F46_RS18930	COG3121	Chaperone
H8F46_RS18950	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H8F46_RS18955	COG0505	Belongs to the CarA family
H8F46_RS18960	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
H8F46_RS18975	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
H8F46_RS18980	COG1047	Peptidyl-prolyl cis-trans
H8F46_RS18985	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
H8F46_RS18990	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H8F46_RS18995	COG0196	riboflavin kinase activity
H8F46_RS19000	COG0268	Binds directly to 16S ribosomal RNA
H8F46_RS19005	COG0583	DNA-binding transcription factor activity
H8F46_RS19010	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H8F46_RS19025	COG0737	Belongs to the 5'-nucleotidase family
H8F46_RS19030	COG1940	carbohydrate kinase activity
H8F46_RS19035	COG2974	May be involved in recombination
H8F46_RS19095	COG0848	biopolymer transport protein
H8F46_RS19105	COG0626	cystathionine gamma-synthase activity
H8F46_RS19115	COG0656	L-ascorbic acid biosynthetic process
H8F46_RS19125	COG3726	membrane protein affecting hemolysin expression
H8F46_RS19130	COG0560	Phosphoserine phosphatase
H8F46_RS19135	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
H8F46_RS19140	COG3335	DDE superfamily endonuclease
H8F46_RS19150	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H8F46_RS19155	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H8F46_RS19170	COG4115	mRNA cleavage
H8F46_RS19180	COG1120	ATPase activity
H8F46_RS19185	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H8F46_RS19190	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H8F46_RS19195	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
H8F46_RS19200	COG4772	TonB-dependent receptor
H8F46_RS19205	COG3712	iron ion homeostasis
H8F46_RS19210	COG1595	DNA-templated transcription, initiation
H8F46_RS19215	COG2873	o-acetylhomoserine
H8F46_RS19265	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H8F46_RS19270	COG1518	maintenance of DNA repeat elements