locus-tag	class	description
XPG1_RS00010	COG0592	DNA-directed DNA polymerase activity
XPG1_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
XPG1_RS00020	COG0187	DNA topoisomerase II activity
XPG1_RS00025	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
XPG1_RS00055	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
XPG1_RS00060	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
XPG1_RS00065	COG0355	proton-transporting ATP synthase activity, rotational mechanism
XPG1_RS00070	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
XPG1_RS00075	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
XPG1_RS00080	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
XPG1_RS00085	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
XPG1_RS00090	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
XPG1_RS00100	COG0356	it plays a direct role in the translocation of protons across the membrane
XPG1_RS00105	COG3312	ion transport
XPG1_RS00110	COG0357	Ribosomal RNA small subunit methyltransferase G
XPG1_RS00115	COG0445	tRNA wobble uridine modification
XPG1_RS00120	COG0716	FMN binding
XPG1_RS00125	COG1522	sequence-specific DNA binding
XPG1_RS00130	COG2502	aspartate--ammonia ligase
XPG1_RS00135	COG2425	protein containing a von Willebrand factor type A (vWA) domain
XPG1_RS00140	COG0714	Associated with various cellular activities
XPG1_RS00145	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
XPG1_RS00150	COG0477	Major facilitator Superfamily
XPG1_RS00175	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
XPG1_RS00180	COG3162	membrane
XPG1_RS00185	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
XPG1_RS00190	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
XPG1_RS00195	COG2258	MOSC domain
XPG1_RS00200	COG0180	Tryptophanyl-tRNA synthetase
XPG1_RS00205	COG0546	phosphoglycolate phosphatase activity
XPG1_RS00210	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
XPG1_RS00225	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
XPG1_RS00230	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
XPG1_RS00235	COG4796	Type ii and iii secretion system protein
XPG1_RS00255	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
XPG1_RS00260	COG0494	nUDIX hydrolase
XPG1_RS00275	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
XPG1_RS00280	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
XPG1_RS00285	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
XPG1_RS00295	COG0583	DNA-binding transcription factor activity
XPG1_RS00300	COG2814	Major facilitator Superfamily
XPG1_RS00320	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
XPG1_RS00330	COG0667	Aldo Keto reductase
XPG1_RS00345	COG0583	DNA-binding transcription factor activity
XPG1_RS00350	COG2081	HI0933 family
XPG1_RS00355	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XPG1_RS00370	COG0789	Transcriptional regulator
XPG1_RS00380	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
XPG1_RS00415	COG0742	ribosomal rna small subunit methyltransferase
XPG1_RS00425	COG0589	response to stress
XPG1_RS00430	COG0306	phosphate transporter
XPG1_RS00435	COG2814	Major facilitator Superfamily
XPG1_RS00445	COG1309	transcriptional regulator
XPG1_RS00460	COG1028	Short-chain dehydrogenase reductase Sdr
XPG1_RS00465	COG0477	Major facilitator Superfamily
XPG1_RS00480	COG1309	transcriptional regulator
XPG1_RS00490	COG1764	response to oxidative stress
XPG1_RS00515	COG0366	Alpha amylase catalytic
XPG1_RS00520	COG1263	PTS System
XPG1_RS00520	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
XPG1_RS00525	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
XPG1_RS00530	COG1349	DNA-binding transcription factor activity
XPG1_RS00535	COG0705	Rhomboid family
XPG1_RS00540	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
XPG1_RS00545	COG0316	Belongs to the HesB IscA family
XPG1_RS00545	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
XPG1_RS00555	COG0596	Alpha beta hydrolase
XPG1_RS00620	COG1918	ferrous iron import across plasma membrane
XPG1_RS00630	COG2183	response to ionizing radiation
XPG1_RS00635	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
XPG1_RS00650	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
XPG1_RS00655	COG0573	inorganic phosphate transmembrane transporter activity
XPG1_RS00660	COG0581	inorganic phosphate transmembrane transporter activity
XPG1_RS00665	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
XPG1_RS00670	COG0704	Plays a role in the regulation of phosphate uptake
XPG1_RS00675	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
XPG1_RS00680	COG0765	amino acid transport
XPG1_RS00685	COG0765	amino acid transport
XPG1_RS00690	COG2252	PERMEase
XPG1_RS00710	COG2204	response regulator
XPG1_RS00815	COG1011	Hydrolase
XPG1_RS00820	COG1490	D-aminoacyl-tRNA deacylase activity
XPG1_RS00825	COG0456	acetyltransferase
XPG1_RS00830	COG2982	Protein involved in outer membrane biogenesis
XPG1_RS00835	COG2233	PERMEase
XPG1_RS00840	COG0786	glutamate:sodium symporter activity
XPG1_RS00845	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
XPG1_RS00850	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
XPG1_RS00860	COG0194	GDP metabolic process
XPG1_RS00865	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
XPG1_RS00870	COG2860	membrane
XPG1_RS00875	COG0823	Involved in the tonB-independent uptake of proteins
XPG1_RS00880	COG5645	(Lipo)protein
XPG1_RS00885	COG3977	Valine--pyruvate aminotransferase
XPG1_RS00890	COG2818	Glycosylase
XPG1_RS00895	COG0752	glycyl-tRNA synthetase alpha subunit
XPG1_RS00900	COG0751	glycine-tRNA ligase activity
XPG1_RS00910	COG0747	negative chemotaxis
XPG1_RS00915	COG0601	transmembrane transport
XPG1_RS00920	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
XPG1_RS00925	COG0444	Belongs to the ABC transporter superfamily
XPG1_RS00930	COG4608	Belongs to the ABC transporter superfamily
XPG1_RS00935	COG2199	diguanylate cyclase activity
XPG1_RS00935	COG2200	EAL domain
XPG1_RS00940	COG0612	Peptidase, M16
XPG1_RS00955	COG1942	4-Oxalocrotonate Tautomerase
XPG1_RS00960	COG1295	ribonuclease BN
XPG1_RS01055	COG3501	Rhs element vgr protein
XPG1_RS01070	COG3209	COG3209 Rhs family protein
XPG1_RS01085	COG2932	Transcriptional regulator
XPG1_RS01090	COG0358	DNA primase activity
XPG1_RS01095	COG4974	Belongs to the 'phage' integrase family
XPG1_RS01105	COG3209	COG3209 Rhs family protein
XPG1_RS01105	COG4104	PAAR repeat-containing protein
XPG1_RS01115	COG4372	Transposase
XPG1_RS01130	COG2801	Transposase and inactivated derivatives
XPG1_RS01160	COG4795	General secretion pathway protein
XPG1_RS01175	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
XPG1_RS01185	COG1074	ATP-dependent DNA helicase activity
XPG1_RS01190	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
XPG1_RS01205	COG0860	N-Acetylmuramoyl-L-alanine amidase
XPG1_RS01225	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
XPG1_RS01230	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
XPG1_RS01235	COG2166	iron-sulfur cluster assembly
XPG1_RS01240	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
XPG1_RS01245	COG0583	DNA-binding transcription factor activity
XPG1_RS01250	COG2363	Small membrane protein
XPG1_RS01260	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
XPG1_RS01265	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
XPG1_RS01270	COG0126	phosphoglycerate kinase activity
XPG1_RS01280	COG3104	oligopeptide transport
XPG1_RS01285	COG2501	S4 domain
XPG1_RS01290	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
XPG1_RS01300	COG0582	viral genome integration into host DNA
XPG1_RS01340	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
XPG1_RS01400	COG0305	Participates in initiation and elongation during chromosome replication
XPG1_RS01495	COG3728	DNA packaging
XPG1_RS01495	COG5484	DNA packaging
XPG1_RS01680	COG0525	valine-tRNA ligase activity
XPG1_RS01685	COG2927	DNA polymerase III (CHI subunit)
XPG1_RS01690	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
XPG1_RS01695	COG0795	lipopolysaccharide-transporting ATPase activity
XPG1_RS01700	COG0795	lipopolysaccharide-transporting ATPase activity
XPG1_RS01705	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
XPG1_RS01775	COG2814	Major facilitator Superfamily
XPG1_RS01785	COG0583	DNA-binding transcription factor activity
XPG1_RS01845	COG1715	Restriction endonuclease
XPG1_RS01855	COG0243	molybdopterin cofactor binding
XPG1_RS01865	COG0419	ATPase involved in DNA repair
XPG1_RS01870	COG0420	3'-5' exonuclease activity
XPG1_RS01875	COG0745	RESPONSE REGULATOR receiver
XPG1_RS01880	COG5002	protein histidine kinase activity
XPG1_RS01895	COG0450	alkyl hydroperoxide reductase
XPG1_RS01900	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
XPG1_RS01905	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
XPG1_RS01910	COG0343	queuine tRNA-ribosyltransferase activity
XPG1_RS01915	COG1862	Preprotein translocase
XPG1_RS01925	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
XPG1_RS01930	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
XPG1_RS01935	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
XPG1_RS01935	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
XPG1_RS01940	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
XPG1_RS01945	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
XPG1_RS01950	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
XPG1_RS01955	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
XPG1_RS01970	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
XPG1_RS01975	COG1757	Na H antiporter
XPG1_RS01980	COG1609	Transcriptional regulator
XPG1_RS01995	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
XPG1_RS02000	COG0142	geranyltranstransferase activity
XPG1_RS02010	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
XPG1_RS02010	COG0301	tRNA thio-modification
XPG1_RS02015	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
XPG1_RS02020	COG1666	GTP binding
XPG1_RS02025	COG2814	Major facilitator Superfamily
XPG1_RS02030	COG0109	protoheme IX farnesyltransferase activity
XPG1_RS02035	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
XPG1_RS02040	COG1845	cytochrome c oxidase, subunit III
XPG1_RS02045	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
XPG1_RS02050	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
XPG1_RS02060	COG2223	nitrite transmembrane transporter activity
XPG1_RS02065	COG3056	Lipoprotein
XPG1_RS02070	COG0271	Belongs to the BolA IbaG family
XPG1_RS02080	COG0740	serine-type endopeptidase activity
XPG1_RS02085	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
XPG1_RS02090	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
XPG1_RS02100	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
XPG1_RS02105	COG1555	photosystem II stabilization
XPG1_RS02110	COG0824	Thioesterase
XPG1_RS02115	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
XPG1_RS02125	COG1522	sequence-specific DNA binding
XPG1_RS02130	COG1132	(ABC) transporter
XPG1_RS02135	COG1132	(ABC) transporter
XPG1_RS02140	COG0347	Belongs to the P(II) protein family
XPG1_RS02145	COG0004	ammonium transporteR
XPG1_RS02160	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XPG1_RS02165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XPG1_RS02170	COG1309	transcriptional regulator
XPG1_RS02180	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
XPG1_RS02190	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
XPG1_RS02195	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
XPG1_RS02200	COG0326	Molecular chaperone. Has ATPase activity
XPG1_RS02205	COG0563	adenylate kinase activity
XPG1_RS02210	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
XPG1_RS02215	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
XPG1_RS02220	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
XPG1_RS02225	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
XPG1_RS02225	COG4651	solute:proton antiporter activity
XPG1_RS02235	COG0737	Belongs to the 5'-nucleotidase family
XPG1_RS02245	COG3735	TraB family
XPG1_RS02250	COG2217	Heavy metal translocating P-type atpase
XPG1_RS02260	COG1585	Membrane protein implicated in regulation of membrane protease activity
XPG1_RS02265	COG0330	HflC and HflK could
XPG1_RS02270	COG3118	belongs to the thioredoxin family
XPG1_RS02275	COG0300	oxidoreductase activity
XPG1_RS02280	COG2755	lipolytic protein G-D-S-L family
XPG1_RS02285	COG4181	ATPase activity
XPG1_RS02290	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
XPG1_RS02305	COG2873	o-acetylhomoserine
XPG1_RS02325	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
XPG1_RS02330	COG1518	maintenance of DNA repeat elements
XPG1_RS02360	COG1203	CRISPR-associated helicase, Cas3
XPG1_RS02385	COG1609	Transcriptional regulator
XPG1_RS02390	COG3265	gluconokinase activity
XPG1_RS02395	COG2610	gluconate transmembrane transporter activity
XPG1_RS02415	COG2992	FlgJ-related protein
XPG1_RS02465	COG1358	cellular component organization or biogenesis
XPG1_RS02475	COG2862	Uncharacterized protein family, UPF0114
XPG1_RS02485	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
XPG1_RS02490	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
XPG1_RS02495	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XPG1_RS02500	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
XPG1_RS02520	COG1177	transmembrane transport
XPG1_RS02530	COG3153	acetyltransferase
XPG1_RS02540	COG3787	Belongs to the UPF0306 family
XPG1_RS02545	COG0602	queuosine metabolic process
XPG1_RS02560	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
XPG1_RS02580	COG5505	Protein of unknown function (DUF819)
XPG1_RS02590	COG0582	viral genome integration into host DNA
XPG1_RS02595	COG0814	amino acid
XPG1_RS02615	COG0534	Mate efflux family protein
XPG1_RS02625	COG0673	inositol 2-dehydrogenase activity
XPG1_RS02635	COG0288	reversible hydration of carbon dioxide
XPG1_RS02640	COG1131	(ABC) transporter
XPG1_RS02645	COG0842	Transport permease protein
XPG1_RS02650	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
XPG1_RS02665	COG1349	DNA-binding transcription factor activity
XPG1_RS02675	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
XPG1_RS02685	COG3716	PTS system mannose fructose sorbose family IID component
XPG1_RS02690	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
XPG1_RS02695	COG2222	sugar isomerase
XPG1_RS02700	COG0191	fructose-bisphosphate aldolase activity
XPG1_RS02705	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
XPG1_RS02710	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
XPG1_RS02715	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
XPG1_RS02720	COG0617	tRNA 3'-terminal CCA addition
XPG1_RS02725	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
XPG1_RS02735	COG1489	DNA binding
XPG1_RS02740	COG1643	Atp-dependent helicase
XPG1_RS02745	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
XPG1_RS02750	COG1278	Cold shock
XPG1_RS02755	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
XPG1_RS02760	COG0316	Belongs to the HesB IscA family
XPG1_RS02765	COG1396	sequence-specific DNA binding
XPG1_RS02770	COG3135	benzoate transporter
XPG1_RS02820	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
XPG1_RS02825	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
XPG1_RS02830	COG0232	Belongs to the dGTPase family. Type 2 subfamily
XPG1_RS02840	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
XPG1_RS02845	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
XPG1_RS02850	COG3956	TIGRFAM MazG family protein
XPG1_RS02855	COG0504	CTP synthase activity
XPG1_RS02860	COG0148	phosphopyruvate hydratase activity
XPG1_RS02865	COG0471	metal ion transport
XPG1_RS02880	COG3091	SprT-like family
XPG1_RS02890	COG1166	arginine decarboxylase activity
XPG1_RS02895	COG0010	Belongs to the arginase family
XPG1_RS02915	COG2345	Transcriptional regulator
XPG1_RS02920	COG1262	PFAM Formylglycine-generating sulfatase enzyme
XPG1_RS02935	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
XPG1_RS02945	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
XPG1_RS02960	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
XPG1_RS02965	COG0626	cystathionine gamma-synthase activity
XPG1_RS02970	COG0242	peptide deformylase activity
XPG1_RS02975	COG3066	DNA modification
XPG1_RS02980	COG0473	3-isopropylmalate dehydrogenase activity
XPG1_RS02995	COG1022	Amp-dependent synthetase and ligase
XPG1_RS03000	COG0028	Belongs to the TPP enzyme family
XPG1_RS03020	COG2001	Belongs to the MraZ family
XPG1_RS03025	COG0275	rRNA processing
XPG1_RS03030	COG3116	cell division
XPG1_RS03035	COG0768	penicillin binding
XPG1_RS03040	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
XPG1_RS03045	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
XPG1_RS03050	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
XPG1_RS03055	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
XPG1_RS03060	COG0772	Belongs to the SEDS family
XPG1_RS03065	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
XPG1_RS03070	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
XPG1_RS03075	COG1181	Belongs to the D-alanine--D-alanine ligase family
XPG1_RS03080	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
XPG1_RS03085	COG0849	cell division
XPG1_RS03095	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
XPG1_RS03110	COG0653	protein targeting
XPG1_RS03115	COG0488	(ABC) transporter
XPG1_RS03120	COG0494	nUDIX hydrolase
XPG1_RS03130	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
XPG1_RS03135	COG0237	dephospho-CoA kinase activity
XPG1_RS03145	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
XPG1_RS03150	COG4969	Belongs to the N-Me-Phe pilin family
XPG1_RS03155	COG3023	N-Acetylmuramoyl-L-alanine amidase
XPG1_RS03160	COG3725	Membrane protein required for beta-lactamase induction
XPG1_RS03165	COG2186	Transcriptional regulator
XPG1_RS03170	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
XPG1_RS03175	COG0508	dehydrogenase complex catalyzes the overall conversion of
XPG1_RS03180	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
XPG1_RS03190	COG2801	Transposase and inactivated derivatives
XPG1_RS03195	COG2963	transposase activity
XPG1_RS03200	COG3246	L-lysine catabolic process to acetate
XPG1_RS03210	COG0183	Belongs to the thiolase family
XPG1_RS03215	COG0113	porphobilinogen synthase activity
XPG1_RS03220	COG0697	spore germination
XPG1_RS03235	COG2313	pseudouridylate synthase activity
XPG1_RS03245	COG0546	phosphoglycolate phosphatase activity
XPG1_RS03255	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
XPG1_RS03285	COG3112	Uncharacterised protein family (UPF0231)
XPG1_RS03290	COG0668	transmembrane transport
XPG1_RS03300	COG0583	DNA-binding transcription factor activity
XPG1_RS03305	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
XPG1_RS03310	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
XPG1_RS03315	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
XPG1_RS03330	COG3079	Belongs to the UPF0149 family
XPG1_RS03335	COG0006	proline dipeptidase activity
XPG1_RS03340	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XPG1_RS03345	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XPG1_RS03350	COG0404	The glycine cleavage system catalyzes the degradation of glycine
XPG1_RS03355	COG0509	glycine decarboxylation via glycine cleavage system
XPG1_RS03360	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
XPG1_RS03360	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
XPG1_RS03370	COG0354	folic acid binding
XPG1_RS03375	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
XPG1_RS03385	COG0716	FMN binding
XPG1_RS03390	COG4974	Belongs to the 'phage' integrase family
XPG1_RS03395	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
XPG1_RS03400	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
XPG1_RS03405	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
XPG1_RS03410	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
XPG1_RS03420	COG0582	viral genome integration into host DNA
XPG1_RS03450	COG5433	transposase activity
XPG1_RS03455	COG3676	manually curated
XPG1_RS03475	COG0741	lytic transglycosylase activity
XPG1_RS03475	COG1388	LysM domain
XPG1_RS03480	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
XPG1_RS03485	COG2226	methyltransferase
XPG1_RS03490	COG0328	RNA-DNA hybrid ribonuclease activity
XPG1_RS03510	COG2197	response regulator
XPG1_RS03520	COG0501	Belongs to the peptidase M48B family
XPG1_RS03530	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
XPG1_RS03540	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
XPG1_RS03545	COG0318	PFAM AMP-dependent synthetase and ligase
XPG1_RS03550	COG1028	Short-chain dehydrogenase reductase Sdr
XPG1_RS03555	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
XPG1_RS03620	COG5301	cellulose 1,4-beta-cellobiosidase activity
XPG1_RS03625	COG1442	glycosyl transferase family 8
XPG1_RS03640	COG5301	cellulose 1,4-beta-cellobiosidase activity
XPG1_RS03650	COG0438	transferase activity, transferring glycosyl groups
XPG1_RS03655	COG5433	transposase activity
XPG1_RS03665	COG2194	sulfuric ester hydrolase activity
XPG1_RS03685	COG0859	PFAM glycosyl transferase family 9
XPG1_RS03730	COG2841	Protein conserved in bacteria
XPG1_RS03770	COG2353	YceI-like domain
XPG1_RS03775	COG3038	cytochrome b561
XPG1_RS03780	COG0625	glutathione transferase activity
XPG1_RS03810	COG2814	Major facilitator Superfamily
XPG1_RS03825	COG2198	Histidine kinase
XPG1_RS03825	COG0642	Histidine kinase
XPG1_RS03830	COG2197	response regulator
XPG1_RS03835	COG2205	protein histidine kinase activity
XPG1_RS03835	COG0784	Response regulator, receiver
XPG1_RS03845	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
XPG1_RS03850	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
XPG1_RS03860	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
XPG1_RS03870	COG3397	chitin binding
XPG1_RS03915	COG2963	transposase activity
XPG1_RS03920	COG2801	Transposase and inactivated derivatives
XPG1_RS03930	COG0582	viral genome integration into host DNA
XPG1_RS03935	COG0582	viral genome integration into host DNA
XPG1_RS04000	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
XPG1_RS04090	COG4626	Terminase
XPG1_RS04090	COG1802	Transcriptional regulator
XPG1_RS04235	COG1802	Transcriptional regulator
XPG1_RS04235	COG4626	Terminase
XPG1_RS04240	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
XPG1_RS04260	COG1674	ftsk spoiiie
XPG1_RS04305	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
XPG1_RS04310	COG2867	negative regulation of translational initiation
XPG1_RS04315	COG2914	Belongs to the UPF0125 (RnfH) family
XPG1_RS04320	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XPG1_RS04325	COG0497	DNA recombination
XPG1_RS04330	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
XPG1_RS04335	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
XPG1_RS04340	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
XPG1_RS04345	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
XPG1_RS04355	COG0513	Belongs to the DEAD box helicase family
XPG1_RS04360	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
XPG1_RS04370	COG1595	DNA-templated transcription, initiation
XPG1_RS04385	COG3086	response to oxidative stress
XPG1_RS04390	COG0481	GTPase activity
XPG1_RS04395	COG0681	Belongs to the peptidase S26 family
XPG1_RS04400	COG0571	ribonuclease III activity
XPG1_RS04405	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
XPG1_RS04410	COG1381	Involved in DNA repair and RecF pathway recombination
XPG1_RS04415	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
XPG1_RS04420	COG0736	holo-[acyl-carrier-protein] synthase activity
XPG1_RS04425	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
XPG1_RS04530	COG3772	lysozyme
XPG1_RS04545	COG1598	PFAM Uncharacterised protein family UPF0150
XPG1_RS04555	COG5484	DNA packaging
XPG1_RS04555	COG3728	DNA packaging
XPG1_RS04560	COG1783	phage Terminase large subunit
XPG1_RS04630	COG0741	lytic transglycosylase activity
XPG1_RS04630	COG1196	nuclear chromosome segregation
XPG1_RS04630	COG0739	heme binding
XPG1_RS04720	COG0590	tRNA wobble adenosine to inosine editing
XPG1_RS04725	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
XPG1_RS04730	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
XPG1_RS04730	COG0047	phosphoribosylformylglycinamidine synthase activity
XPG1_RS04735	COG2205	protein histidine kinase activity
XPG1_RS04740	COG3170	Tfp pilus assembly protein FimV
XPG1_RS04745	COG2204	response regulator
XPG1_RS04750	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
XPG1_RS04750	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
XPG1_RS04755	COG0347	Belongs to the P(II) protein family
XPG1_RS04760	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
XPG1_RS04760	COG1017	nitric oxide dioxygenase activity
XPG1_RS04765	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
XPG1_RS04770	COG2814	Major facilitator Superfamily
XPG1_RS04775	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
XPG1_RS04780	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
XPG1_RS04785	COG1120	ATPase activity
XPG1_RS04800	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
XPG1_RS04800	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
XPG1_RS04805	COG4607	ABC-type enterochelin transport system periplasmic component
XPG1_RS04810	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
XPG1_RS04815	COG4774	siderophore transport
XPG1_RS04815	COG1629	transport
XPG1_RS04820	COG0662	Cupin 2, conserved barrel domain protein
XPG1_RS04825	COG1028	Short-chain dehydrogenase reductase Sdr
XPG1_RS04830	COG3433	isochorismatase activity
XPG1_RS04830	COG1535	isochorismatase
XPG1_RS04835	COG1021	2,3-dihydroxybenzoate-AMP ligase
XPG1_RS04840	COG1169	isochorismate synthase
XPG1_RS04860	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
XPG1_RS04865	COG1959	2 iron, 2 sulfur cluster binding
XPG1_RS04870	COG1104	cysteine desulfurase activity
XPG1_RS04875	COG0822	iron-sulfur transferase activity
XPG1_RS04880	COG0316	Belongs to the HesB IscA family
XPG1_RS04885	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
XPG1_RS04890	COG0443	Heat shock 70 kDa protein
XPG1_RS04895	COG0633	Ferredoxin
XPG1_RS04900	COG2975	iron-sulfur cluster assembly
XPG1_RS04905	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
XPG1_RS04915	COG2373	Large extracellular alpha-helical protein
XPG1_RS04920	COG4953	penicillin-binding protein 1C
XPG1_RS04930	COG3655	Transcriptional regulator
XPG1_RS04940	COG0105	UTP biosynthetic process
XPG1_RS04945	COG0820	rRNA (adenine-C2-)-methyltransferase activity
XPG1_RS04960	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
XPG1_RS04965	COG0124	histidyl-tRNA synthetase
XPG1_RS04970	COG2976	Protein conserved in bacteria
XPG1_RS04975	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XPG1_RS04980	COG1160	GTP binding
XPG1_RS04995	COG0408	coproporphyrinogen oxidase activity
XPG1_RS05000	COG3423	Transcriptional regulator
XPG1_RS05010	COG4626	Terminase
XPG1_RS05010	COG1802	Transcriptional regulator
XPG1_RS05090	COG0456	acetyltransferase
XPG1_RS05100	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
XPG1_RS05105	COG4208	sulfate ABC transporter
XPG1_RS05110	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
XPG1_RS05115	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
XPG1_RS05120	COG2190	(PTS) system
XPG1_RS05130	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
XPG1_RS05150	COG3115	cell septum assembly
XPG1_RS05155	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
XPG1_RS05160	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
XPG1_RS05165	COG3530	Putative quorum-sensing-regulated virulence factor
XPG1_RS05170	COG1028	Short-chain dehydrogenase reductase Sdr
XPG1_RS05180	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
XPG1_RS05255	COG3691	Protein conserved in bacteria
XPG1_RS05260	COG0183	Belongs to the thiolase family
XPG1_RS05265	COG1024	Enoyl-CoA hydratase
XPG1_RS05265	COG1250	3-hydroxyacyl-CoA dehydrogenase
XPG1_RS05270	COG2062	phosphohistidine phosphatase, SixA
XPG1_RS05275	COG2840	Smr protein MutS2
XPG1_RS05280	COG1228	amidohydrolase
XPG1_RS05285	COG0010	Belongs to the arginase family
XPG1_RS05295	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
XPG1_RS05300	COG2986	histidine ammonia-lyase
XPG1_RS05325	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
XPG1_RS05330	COG0730	response to heat
XPG1_RS05335	COG3101	peptidyl-lysine hydroxylation
XPG1_RS05345	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
XPG1_RS05345	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XPG1_RS05350	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
XPG1_RS05375	COG0640	Transcriptional regulator
XPG1_RS05390	COG0642	Histidine kinase
XPG1_RS05400	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
XPG1_RS05405	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
XPG1_RS05410	COG0101	tRNA pseudouridine synthase activity
XPG1_RS05415	COG0586	Pfam SNARE associated Golgi protein
XPG1_RS05420	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
XPG1_RS05425	COG0285	dihydrofolate synthase activity
XPG1_RS05430	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
XPG1_RS05435	COG1286	toxin biosynthetic process
XPG1_RS05440	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
XPG1_RS05445	COG0163	prenyltransferase activity
XPG1_RS05450	COG1090	epimerase
XPG1_RS05455	COG0625	glutathione transferase activity
XPG1_RS05465	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
XPG1_RS05470	COG3138	arginine N-succinyltransferase
XPG1_RS05475	COG1012	belongs to the aldehyde dehydrogenase family
XPG1_RS05480	COG3724	N-succinylarginine dihydrolase activity
XPG1_RS05485	COG2988	succinylglutamate desuccinylase activity
XPG1_RS05490	COG1113	amino acid transport
XPG1_RS05510	COG0280	phosphate acetyltransferase
XPG1_RS05510	COG0857	belongs to the CobB CobQ family
XPG1_RS05515	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
XPG1_RS05525	COG0490	domain, Protein
XPG1_RS05525	COG0471	metal ion transport
XPG1_RS05530	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
XPG1_RS05535	COG0436	Aminotransferase
XPG1_RS05540	COG0583	DNA-binding transcription factor activity
XPG1_RS05545	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XPG1_RS05550	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XPG1_RS05555	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XPG1_RS05555	COG0649	NAD binding
XPG1_RS05570	COG1034	ATP synthesis coupled electron transport
XPG1_RS05580	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XPG1_RS05585	COG0839	Belongs to the complex I subunit 6 family
XPG1_RS05590	COG0713	ATP synthesis coupled electron transport
XPG1_RS05595	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
XPG1_RS05600	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XPG1_RS05605	COG1007	ATP synthesis coupled electron transport
XPG1_RS05610	COG2200	EAL domain
XPG1_RS05620	COG2199	diguanylate cyclase activity
XPG1_RS05635	COG1215	transferase activity, transferring glycosyl groups
XPG1_RS05640	COG0726	polysaccharide deacetylase
XPG1_RS05640	COG1649	PFAM Uncharacterised BCR, COG1649
XPG1_RS05645	COG0457	Tetratricopeptide repeat
XPG1_RS05660	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
XPG1_RS05665	COG0596	Alpha beta hydrolase
XPG1_RS05670	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
XPG1_RS05675	COG1441	menaquinone biosynthetic process
XPG1_RS05690	COG0814	amino acid
XPG1_RS05695	COG2814	Major facilitator Superfamily
XPG1_RS05705	COG3093	addiction module antidote protein HigA
XPG1_RS05730	COG2189	Belongs to the N(4) N(6)-methyltransferase family
XPG1_RS05745	COG3676	manually curated
XPG1_RS05770	COG3083	sulfuric ester hydrolase activity
XPG1_RS05775	COG3082	Protein of unknown function (DUF1414)
XPG1_RS05780	COG3081	Nucleoid-associated protein
XPG1_RS05785	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
XPG1_RS05790	COG1061	Type III restriction enzyme res subunit
XPG1_RS05795	COG1187	pseudouridine synthase activity
XPG1_RS05800	COG2814	Major facilitator Superfamily
XPG1_RS05810	COG0791	NLP P60 protein
XPG1_RS05815	COG0671	phosphoesterase, PA-phosphatase related
XPG1_RS05830	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
XPG1_RS05840	COG1105	Belongs to the carbohydrate kinase PfkB family
XPG1_RS05845	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
XPG1_RS05850	COG2855	membrane
XPG1_RS05855	COG0583	DNA-binding transcription factor activity
XPG1_RS05860	COG0833	amino acid
XPG1_RS05870	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
XPG1_RS05875	COG1120	ATPase activity
XPG1_RS05880	COG4771	TonB-dependent receptor
XPG1_RS05885	COG0531	amino acid
XPG1_RS05890	COG0277	FAD linked oxidase domain protein
XPG1_RS05895	COG2925	Exonuclease
XPG1_RS05915	COG2926	Belongs to the UPF0265 family
XPG1_RS05920	COG0702	epimerase
XPG1_RS05925	COG1530	ribonuclease E activity
XPG1_RS05930	COG0564	pseudouridine synthase activity
XPG1_RS05935	COG0424	maF-like protein
XPG1_RS05940	COG1399	metal-binding, possibly nucleic acid-binding protein
XPG1_RS05945	COG0333	Belongs to the bacterial ribosomal protein bL32 family
XPG1_RS05950	COG0416	fatty acid biosynthetic process
XPG1_RS05955	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
XPG1_RS05970	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
XPG1_RS05975	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
XPG1_RS05980	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
XPG1_RS05985	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
XPG1_RS05990	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
XPG1_RS05995	COG0470	DNA polymerase III
XPG1_RS06000	COG0084	hydrolase, TatD family'
XPG1_RS06005	COG0537	adenosine 5'-monophosphoramidase activity
XPG1_RS06010	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
XPG1_RS06020	COG1472	Belongs to the glycosyl hydrolase 3 family
XPG1_RS06025	COG1252	NADH dehydrogenase
XPG1_RS06065	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
XPG1_RS06070	COG4591	ABC-type transport system involved in lipoprotein release permease component
XPG1_RS06075	COG1136	(ABC) transporter
XPG1_RS06080	COG4591	ABC-type transport system involved in lipoprotein release permease component
XPG1_RS06085	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
XPG1_RS06090	COG2195	Cleaves the N-terminal amino acid of tripeptides
XPG1_RS06095	COG2850	peptidyl-arginine hydroxylation
XPG1_RS06100	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
XPG1_RS06105	COG2205	protein histidine kinase activity
XPG1_RS06110	COG0745	RESPONSE REGULATOR receiver
XPG1_RS06115	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
XPG1_RS06120	COG2915	High frequency lysogenization protein hflD homolog
XPG1_RS06125	COG0482	sulfurtransferase activity
XPG1_RS06130	COG1187	pseudouridine synthase activity
XPG1_RS06135	COG0538	isocitrate dehydrogenase activity
XPG1_RS06140	COG0582	viral genome integration into host DNA
XPG1_RS06175	COG3723	Recombinational DNA repair protein, rece pathway
XPG1_RS06180	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
XPG1_RS06235	COG1846	Transcriptional regulator
XPG1_RS06330	COG1783	phage Terminase large subunit
XPG1_RS06350	COG2369	cell adhesion
XPG1_RS06460	COG0538	isocitrate dehydrogenase activity
XPG1_RS06485	COG1115	amino acid carrier protein
XPG1_RS06490	COG2207	Transcriptional regulator
XPG1_RS06490	COG3708	Transcriptional regulator
XPG1_RS06505	COG0351	phosphomethylpyrimidine kinase
XPG1_RS06510	COG1830	Aldolase
XPG1_RS06515	COG0826	peptidase U32
XPG1_RS06520	COG2814	Major facilitator Superfamily
XPG1_RS06525	COG0745	RESPONSE REGULATOR receiver
XPG1_RS06530	COG2205	protein histidine kinase activity
XPG1_RS06535	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XPG1_RS06540	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XPG1_RS06545	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XPG1_RS06550	COG2239	Acts as a magnesium transporter
XPG1_RS06560	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
XPG1_RS06565	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
XPG1_RS06570	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
XPG1_RS06575	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
XPG1_RS06580	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
XPG1_RS06585	COG2233	PERMEase
XPG1_RS06590	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
XPG1_RS06595	COG1393	Belongs to the ArsC family
XPG1_RS06600	COG4783	chaperone-mediated protein folding
XPG1_RS06605	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
XPG1_RS06610	COG2716	regulation of RNA biosynthetic process
XPG1_RS06615	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
XPG1_RS06620	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
XPG1_RS06625	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
XPG1_RS06640	COG2707	UPF0756 membrane protein
XPG1_RS06645	COG1444	tRNA N-acetyltransferase activity
XPG1_RS06655	COG1876	peptidase activity
XPG1_RS06660	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
XPG1_RS06665	COG1393	Belongs to the ArsC family
XPG1_RS06670	COG2197	response regulator
XPG1_RS06675	COG0281	malic enzyme
XPG1_RS06675	COG0280	phosphate acetyltransferase
XPG1_RS06685	COG1570	exodeoxyribonuclease VII activity
XPG1_RS06690	COG0516	GMP reductase activity
XPG1_RS06690	COG0517	IMP dehydrogenase activity
XPG1_RS06695	COG0519	Catalyzes the synthesis of GMP from XMP
XPG1_RS06695	COG0518	GMP synthase (glutamine-hydrolyzing) activity
XPG1_RS06700	COG0582	viral genome integration into host DNA
XPG1_RS06775	COG2197	response regulator
XPG1_RS06780	COG3851	Histidine kinase
XPG1_RS06785	COG2271	Major facilitator Superfamily
XPG1_RS06795	COG2226	methyltransferase
XPG1_RS06800	COG1971	Probably functions as a manganese efflux pump
XPG1_RS06805	COG4811	Protein of unknown function (DUF986)
XPG1_RS06810	COG3716	PTS system mannose fructose sorbose family IID component
XPG1_RS06815	COG3715	PTS system
XPG1_RS06820	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
XPG1_RS06820	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
XPG1_RS06825	COG1760	l-serine dehydratase
XPG1_RS06830	COG0494	nUDIX hydrolase
XPG1_RS06840	COG3140	Belongs to the UPF0181 family
XPG1_RS06860	COG1528	Iron-storage protein
XPG1_RS06865	COG2372	response to copper ion
XPG1_RS06870	COG1276	copper resistance
XPG1_RS06880	COG1956	GAF domain-containing protein
XPG1_RS06885	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
XPG1_RS06895	COG0501	Belongs to the peptidase M48B family
XPG1_RS06900	COG1823	symporter activity
XPG1_RS06905	COG1988	membrane-bound metal-dependent
XPG1_RS06910	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
XPG1_RS06915	COG3001	Fructosamine kinase
XPG1_RS06920	COG1108	ABC-type Mn2 Zn2 transport systems permease components
XPG1_RS06925	COG1108	ABC-type Mn2 Zn2 transport systems permease components
XPG1_RS06930	COG1121	(ABC) transporter
XPG1_RS06935	COG0803	Belongs to the bacterial solute-binding protein 9 family
XPG1_RS06940	COG0741	lytic transglycosylase activity
XPG1_RS06945	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
XPG1_RS06950	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
XPG1_RS06955	COG0291	Belongs to the bacterial ribosomal protein bL35 family
XPG1_RS06970	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
XPG1_RS06970	COG0072	phenylalanine-tRNA ligase activity
XPG1_RS06975	COG0776	regulation of translation
XPG1_RS06980	COG4139	cobalamin transport
XPG1_RS06985	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
XPG1_RS06990	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
XPG1_RS06995	COG0463	Glycosyl transferase, family 2
XPG1_RS07000	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
XPG1_RS07000	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
XPG1_RS07005	COG0726	polysaccharide deacetylase
XPG1_RS07010	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
XPG1_RS07015	COG2076	Multidrug Resistance protein
XPG1_RS07020	COG2076	Multidrug Resistance protein
XPG1_RS07025	COG0791	NLP P60 protein
XPG1_RS07030	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
XPG1_RS07035	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
XPG1_RS07040	COG4558	Periplasmic binding protein
XPG1_RS07045	COG3720	iron ion transport
XPG1_RS07050	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
XPG1_RS07055	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
XPG1_RS07060	COG0574	Belongs to the PEP-utilizing enzyme family
XPG1_RS07060	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
XPG1_RS07065	COG0628	permease
XPG1_RS07070	COG0247	lactate metabolic process
XPG1_RS07070	COG0277	FAD linked oxidase domain protein
XPG1_RS07075	COG2050	protein possibly involved in aromatic compounds catabolism
XPG1_RS07080	COG1388	LysM domain
XPG1_RS07080	COG1376	ErfK ybiS ycfS ynhG family protein
XPG1_RS07085	COG4238	major outer membrane lipoprotein
XPG1_RS07105	COG0534	Mate efflux family protein
XPG1_RS07110	COG0307	riboflavin synthase, alpha
XPG1_RS07115	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
XPG1_RS07120	COG2814	Major facilitator Superfamily
XPG1_RS07125	COG0583	DNA-binding transcription factor activity
XPG1_RS07130	COG1609	Transcriptional regulator
XPG1_RS07140	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
XPG1_RS07145	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
XPG1_RS07150	COG0346	lactoylglutathione lyase activity
XPG1_RS07160	COG3133	Outer membrane lipoprotein
XPG1_RS07165	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
XPG1_RS07170	COG0259	pyridoxamine-phosphate oxidase activity
XPG1_RS07175	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
XPG1_RS07180	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
XPG1_RS07195	COG4172	Belongs to the ABC transporter superfamily
XPG1_RS07200	COG4171	peptide transport system, permease
XPG1_RS07210	COG4166	transmembrane transport
XPG1_RS07215	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
XPG1_RS07220	COG1842	Phage shock protein A
XPG1_RS07230	COG1983	PspC domain protein
XPG1_RS07235	COG3106	COG3106 Predicted ATPase
XPG1_RS07255	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
XPG1_RS07260	COG0598	Magnesium transport protein CorA
XPG1_RS07265	COG0037	tRNA processing
XPG1_RS07285	COG1132	(ABC) transporter
XPG1_RS07300	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
XPG1_RS07305	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
XPG1_RS07310	COG2186	Transcriptional regulator
XPG1_RS07315	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XPG1_RS07320	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
XPG1_RS07345	COG3139	Protein of unknown function (DUF1315)
XPG1_RS07360	COG1335	isochorismatase
XPG1_RS07365	COG0252	asparaginase activity
XPG1_RS07370	COG0616	signal peptide processing
XPG1_RS07375	COG0778	Nitroreductase
XPG1_RS07380	COG0709	Synthesizes selenophosphate from selenide and ATP
XPG1_RS07380	COG0709	Synthesizes selenophosphate from selenide and ATP
XPG1_RS07385	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
XPG1_RS07390	COG0708	Exodeoxyribonuclease III
XPG1_RS07405	COG0788	formyltetrahydrofolate deformylase activity
XPG1_RS07410	COG3012	SEC-C Motif Domain Protein
XPG1_RS07415	COG1210	Utp--glucose-1-phosphate uridylyltransferase
XPG1_RS07430	COG2916	Histone family protein nucleoid-structuring protein H-NS
XPG1_RS07435	COG1435	thymidine kinase activity
XPG1_RS07440	COG1012	belongs to the aldehyde dehydrogenase family
XPG1_RS07440	COG1454	alcohol dehydrogenase
XPG1_RS07455	COG0601	transmembrane transport
XPG1_RS07460	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
XPG1_RS07465	COG0444	Belongs to the ABC transporter superfamily
XPG1_RS07470	COG4608	Belongs to the ABC transporter superfamily
XPG1_RS07475	COG3099	Belongs to the UPF0263 family
XPG1_RS07480	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XPG1_RS07485	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
XPG1_RS07495	COG2917	probably involved in intracellular septation
XPG1_RS07505	COG3047	cAMP biosynthetic process
XPG1_RS07510	COG0159	tryptophan synthase activity
XPG1_RS07515	COG0133	tryptophan synthase activity
XPG1_RS07525	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
XPG1_RS07530	COG0512	Glutamine amidotransferase of anthranilate synthase
XPG1_RS07545	COG0009	L-threonylcarbamoyladenylate synthase
XPG1_RS07560	COG1028	Short-chain dehydrogenase reductase Sdr
XPG1_RS07565	COG0616	signal peptide processing
XPG1_RS07580	COG0583	DNA-binding transcription factor activity
XPG1_RS07600	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
XPG1_RS07605	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
XPG1_RS07610	COG0284	orotidine-5'-phosphate decarboxylase activity
XPG1_RS07615	COG0023	Translation Initiation Factor
XPG1_RS07625	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
XPG1_RS07630	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
XPG1_RS07640	COG4659	FMN binding
XPG1_RS07645	COG4658	electron transport chain
XPG1_RS07650	COG4656	Part of a membrane complex involved in electron transport
XPG1_RS07660	COG4657	Part of a membrane complex involved in electron transport
XPG1_RS07665	COG0673	inositol 2-dehydrogenase activity
XPG1_RS07670	COG0385	Bile acid
XPG1_RS07675	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
XPG1_RS07680	COG5339	Protein conserved in bacteria
XPG1_RS07685	COG1482	cell wall glycoprotein biosynthetic process
XPG1_RS07690	COG0114	fumarate hydratase activity
XPG1_RS07700	COG2814	Major facilitator Superfamily
XPG1_RS07705	COG0583	DNA-binding transcription factor activity
XPG1_RS07720	COG1940	carbohydrate kinase activity
XPG1_RS07725	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
XPG1_RS07740	COG4221	oxidoreductase activity
XPG1_RS07745	COG1132	(ABC) transporter
XPG1_RS07820	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
XPG1_RS07820	COG2169	Transcriptional regulator
XPG1_RS07825	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
XPG1_RS07840	COG0583	DNA-binding transcription factor activity
XPG1_RS07850	COG1280	lysine exporter protein (LysE YggA)
XPG1_RS07865	COG4771	TonB-dependent receptor
XPG1_RS07875	COG0697	spore germination
XPG1_RS07885	COG0456	acetyltransferase
XPG1_RS07910	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
XPG1_RS07915	COG0589	response to stress
XPG1_RS07920	COG4974	Belongs to the 'phage' integrase family
XPG1_RS07940	COG5433	transposase activity
XPG1_RS07950	COG0384	phenazine biosynthesis protein PhzF
XPG1_RS07955	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
XPG1_RS07960	COG0477	Major facilitator Superfamily
XPG1_RS07965	COG1028	Short-chain dehydrogenase reductase Sdr
XPG1_RS07985	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
XPG1_RS07990	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
XPG1_RS08000	COG0531	amino acid
XPG1_RS08010	COG3121	Chaperone
XPG1_RS08035	COG0577	efflux transmembrane transporter activity
XPG1_RS08035	COG1136	(ABC) transporter
XPG1_RS08040	COG1136	(ABC) transporter
XPG1_RS08055	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
XPG1_RS08065	COG1643	Atp-dependent helicase
XPG1_RS08070	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
XPG1_RS08075	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
XPG1_RS08085	COG2983	Belongs to the UPF0260 family
XPG1_RS08090	COG0179	Fumarylacetoacetate (FAA) hydrolase
XPG1_RS08095	COG2951	lytic endotransglycosylase activity
XPG1_RS08100	COG3100	YcgL domain-containing protein
XPG1_RS08105	COG0850	regulation of cytokinetic process
XPG1_RS08110	COG2894	cell division
XPG1_RS08115	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
XPG1_RS08120	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
XPG1_RS08125	COG0318	PFAM AMP-dependent synthetase and ligase
XPG1_RS08135	COG1199	ATP-dependent helicase activity
XPG1_RS08140	COG0251	oxidation-reduction process
XPG1_RS08145	COG2076	Multidrug Resistance protein
XPG1_RS08150	COG2076	Multidrug Resistance protein
XPG1_RS08155	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
XPG1_RS08160	COG1737	Transcriptional regulator
XPG1_RS08165	COG0469	pyruvate kinase activity
XPG1_RS08170	COG1560	Kdo2-lipid A biosynthetic process
XPG1_RS08175	COG0739	heme binding
XPG1_RS08180	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
XPG1_RS08185	COG1121	(ABC) transporter
XPG1_RS08190	COG1108	ABC-type Mn2 Zn2 transport systems permease components
XPG1_RS08200	COG2255	four-way junction helicase activity
XPG1_RS08205	COG0632	four-way junction helicase activity
XPG1_RS08210	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
XPG1_RS08215	COG0217	transcriptional regulatory protein
XPG1_RS08220	COG0494	nUDIX hydrolase
XPG1_RS08225	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
XPG1_RS08230	COG3788	relative of glutathione S-transferase, MAPEG superfamily
XPG1_RS08235	COG2226	methyltransferase
XPG1_RS08240	COG0500	methyltransferase
XPG1_RS08245	COG3142	Participates in the control of copper homeostasis
XPG1_RS08250	COG3102	Protein conserved in bacteria
XPG1_RS08255	COG0018	arginyl-trna synthetase
XPG1_RS08380	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
XPG1_RS08390	COG3381	protein complex oligomerization
XPG1_RS08395	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
XPG1_RS08430	COG2814	Major facilitator Superfamily
XPG1_RS08445	COG5433	transposase activity
XPG1_RS08475	COG2378	regulation of single-species biofilm formation
XPG1_RS08490	COG0488	(ABC) transporter
XPG1_RS08495	COG0659	secondary active sulfate transmembrane transporter activity
XPG1_RS08500	COG2877	3-deoxy-8-phosphooctulonate synthase activity
XPG1_RS08515	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
XPG1_RS08520	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
XPG1_RS08525	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
XPG1_RS08530	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
XPG1_RS08535	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
XPG1_RS08555	COG0193	aminoacyl-tRNA hydrolase activity
XPG1_RS08560	COG0012	GTP binding
XPG1_RS08590	COG0579	oxidoreductase
XPG1_RS08600	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
XPG1_RS08605	COG1271	oxidase subunit
XPG1_RS08610	COG1294	oxidase, subunit
XPG1_RS08615	COG2356	endonuclease I
XPG1_RS08635	COG1335	isochorismatase
XPG1_RS08660	COG0531	amino acid
XPG1_RS08665	COG1982	Orn Lys Arg decarboxylase major
XPG1_RS08680	COG0076	glutamate decarboxylase activity
XPG1_RS08690	COG0583	DNA-binding transcription factor activity
XPG1_RS08695	COG1301	dicarboxylic acid transport
XPG1_RS08715	COG2084	Dehydrogenase
XPG1_RS08720	COG2814	Major facilitator Superfamily
XPG1_RS08750	COG1028	Short-chain dehydrogenase reductase Sdr
XPG1_RS08760	COG1309	transcriptional regulator
XPG1_RS08765	COG0814	amino acid
XPG1_RS08770	COG2826	transposase and inactivated derivatives, IS30 family
XPG1_RS08940	COG3423	Transcriptional regulator
XPG1_RS08945	COG1802	Transcriptional regulator
XPG1_RS08945	COG4626	Terminase
XPG1_RS09075	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
XPG1_RS09080	COG0322	excinuclease ABC activity
XPG1_RS09085	COG2197	response regulator
XPG1_RS09105	COG1113	amino acid transport
XPG1_RS09110	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
XPG1_RS09115	COG0506	proline dehydrogenase activity
XPG1_RS09115	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
XPG1_RS09115	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
XPG1_RS09125	COG1191	sigma factor activity
XPG1_RS09160	COG1677	Flagellar hook-basal body complex protein FliE
XPG1_RS09165	COG1766	The M ring may be actively involved in energy transduction
XPG1_RS09180	COG1157	protein secretion by the type III secretion system
XPG1_RS09190	COG3144	bacterial-type flagellum assembly
XPG1_RS09200	COG1580	Controls the rotational direction of flagella during chemotaxis
XPG1_RS09225	COG1987	bacterial-type flagellum assembly
XPG1_RS09240	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
XPG1_RS09245	COG1256	bacterial-type flagellum assembly
XPG1_RS09255	COG1706	bacterial-type flagellum-dependent cell motility
XPG1_RS09260	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
XPG1_RS09285	COG1558	bacterial-type flagellum-dependent cell motility
XPG1_RS09290	COG1815	bacterial-type flagellum-dependent cell motility
XPG1_RS09310	COG3539	Fimbrial protein
XPG1_RS09315	COG3121	Chaperone
XPG1_RS09330	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
XPG1_RS09335	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
XPG1_RS09340	COG1115	amino acid carrier protein
XPG1_RS09350	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
XPG1_RS09355	COG0745	RESPONSE REGULATOR receiver
XPG1_RS09360	COG2201	protein-glutamate methylesterase activity
XPG1_RS09365	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
XPG1_RS09370	COG0840	transmembrane signaling receptor activity
XPG1_RS09380	COG0835	chemotaxis
XPG1_RS09385	COG0643	Histidine kinase
XPG1_RS09385	COG2198	Histidine kinase
XPG1_RS09395	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
XPG1_RS09415	COG1285	pathogenesis
XPG1_RS09455	COG0418	dihydroorotase activity
XPG1_RS09465	COG1054	Belongs to the UPF0176 family
XPG1_RS09470	COG1560	Kdo2-lipid A biosynthetic process
XPG1_RS09495	COG1304	FMN binding
XPG1_RS09500	COG1620	l-lactate permease
XPG1_RS09510	COG3545	Serine hydrolase
XPG1_RS09520	COG5433	transposase activity
XPG1_RS09545	COG1733	regulation of RNA biosynthetic process
XPG1_RS09550	COG2814	Major facilitator Superfamily
XPG1_RS09555	COG0583	DNA-binding transcription factor activity
XPG1_RS09585	COG2920	part of a sulfur-relay system
XPG1_RS09590	COG1254	Belongs to the acylphosphatase family
XPG1_RS09595	COG3785	DNA binding
XPG1_RS09600	COG1832	CoA-binding protein
XPG1_RS09605	COG0210	DNA helicase
XPG1_RS09610	COG1289	transmembrane transporter activity
XPG1_RS09620	COG3070	regulator of competence-specific genes
XPG1_RS09625	COG5404	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
XPG1_RS09635	COG3120	sequence-specific DNA binding
XPG1_RS09640	COG1067	ATP-dependent peptidase activity
XPG1_RS09645	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
XPG1_RS09650	COG3009	Protein conserved in bacteria
XPG1_RS09655	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
XPG1_RS09655	COG3008	intermembrane lipid transfer
XPG1_RS09660	COG2995	paraquat-inducible protein a
XPG1_RS09665	COG0488	(ABC) transporter
XPG1_RS09670	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
XPG1_RS09670	COG0116	Belongs to the methyltransferase superfamily
XPG1_RS09675	COG3217	Mosc domain protein beta barrel domain protein
XPG1_RS09675	COG0633	Ferredoxin
XPG1_RS09685	COG0167	dihydroorotate dehydrogenase activity
XPG1_RS09690	COG0640	Transcriptional regulator
XPG1_RS09710	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
XPG1_RS09725	COG2186	Transcriptional regulator
XPG1_RS09730	COG3734	2-keto-3-deoxy-galactonokinase
XPG1_RS09735	COG0800	Aldolase
XPG1_RS09740	COG4948	Mandelate Racemase Muconate Lactonizing
XPG1_RS09745	COG2271	Major facilitator Superfamily
XPG1_RS09750	COG0308	aminopeptidase N
XPG1_RS09755	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
XPG1_RS09760	COG0017	Asparaginyl-tRNA synthetase
XPG1_RS09765	COG2801	Transposase and inactivated derivatives
XPG1_RS09770	COG2963	transposase activity
XPG1_RS09775	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
XPG1_RS09780	COG1448	Aminotransferase
XPG1_RS09785	COG2801	Transposase and inactivated derivatives
XPG1_RS09790	COG2963	transposase activity
XPG1_RS09795	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
XPG1_RS09800	COG3108	Peptidase M15
XPG1_RS09805	COG2989	Protein conserved in bacteria
XPG1_RS09810	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
XPG1_RS09815	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
XPG1_RS09820	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
XPG1_RS09825	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
XPG1_RS09830	COG1434	Gram-negative-bacterium-type cell wall biogenesis
XPG1_RS09840	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
XPG1_RS09845	COG2835	tetraacyldisaccharide 4'-kinase activity
XPG1_RS09850	COG1663	tetraacyldisaccharide 4'-kinase activity
XPG1_RS09855	COG1132	(ABC) transporter
XPG1_RS09860	COG2333	competence protein COMEC
XPG1_RS09860	COG0658	competence protein
XPG1_RS09870	COG0539	negative regulation of cytoplasmic translation
XPG1_RS09875	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
XPG1_RS09880	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
XPG1_RS09885	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
XPG1_RS09890	COG0252	asparaginase activity
XPG1_RS09895	COG1944	ATP diphosphatase activity
XPG1_RS09900	COG2116	formate transmembrane transporter activity
XPG1_RS09905	COG1882	Formate acetyltransferase
XPG1_RS09910	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
XPG1_RS09920	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
XPG1_RS09925	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
XPG1_RS09930	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
XPG1_RS09935	COG1674	ftsk spoiiie
XPG1_RS09935	COG3107	peptidoglycan biosynthetic process
XPG1_RS09940	COG1522	sequence-specific DNA binding
XPG1_RS09945	COG0492	ferredoxin-NADP+ reductase activity
XPG1_RS09955	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
XPG1_RS09960	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
XPG1_RS09970	COG0542	response to heat
XPG1_RS09975	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
XPG1_RS09980	COG1278	Cold shock
XPG1_RS09985	COG1136	(ABC) transporter
XPG1_RS09985	COG0577	efflux transmembrane transporter activity
XPG1_RS09990	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XPG1_RS09995	COG2431	L-lysine efflux transmembrane transporter activity
XPG1_RS10000	COG1126	abc transporter atp-binding protein
XPG1_RS10005	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
XPG1_RS10010	COG4215	(ABC) transporter
XPG1_RS10015	COG4160	amino acid transport
XPG1_RS10020	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
XPG1_RS10040	COG0671	phosphoesterase, PA-phosphatase related
XPG1_RS10045	COG0814	amino acid
XPG1_RS10050	COG1686	Belongs to the peptidase S11 family
XPG1_RS10055	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
XPG1_RS10060	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
XPG1_RS10065	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
XPG1_RS10065	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
XPG1_RS10070	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
XPG1_RS10070	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
XPG1_RS10075	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
XPG1_RS10075	COG0131	Imidazoleglycerol-phosphate dehydratase
XPG1_RS10080	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
XPG1_RS10085	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
XPG1_RS10090	COG0107	imidazoleglycerol-phosphate synthase activity
XPG1_RS10095	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
XPG1_RS10095	COG0140	phosphoribosyl-ATP diphosphatase activity
XPG1_RS10100	COG1454	alcohol dehydrogenase
XPG1_RS10105	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
XPG1_RS10115	COG1253	flavin adenine dinucleotide binding
XPG1_RS10120	COG2982	Protein involved in outer membrane biogenesis
XPG1_RS10125	COG0717	Belongs to the dCTP deaminase family
XPG1_RS10130	COG0572	uridine kinase
XPG1_RS10145	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
XPG1_RS10145	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
XPG1_RS10150	COG1380	Effector of murein hydrolase LrgA
XPG1_RS10155	COG1346	cytolysis
XPG1_RS10165	COG0281	malic enzyme
XPG1_RS10170	COG2949	membrane
XPG1_RS10175	COG2311	Membrane
XPG1_RS10180	COG0302	gtp cyclohydrolase
XPG1_RS10185	COG0477	Major facilitator Superfamily
XPG1_RS10200	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
XPG1_RS10205	COG0488	(ABC) transporter
XPG1_RS10215	COG5006	permease, DMT superfamily
XPG1_RS10220	COG2824	Alkylphosphonate utilization operon protein PhnA
XPG1_RS10240	COG1199	ATP-dependent helicase activity
XPG1_RS10245	COG2897	thiosulfate sulfurtransferase activity
XPG1_RS10250	COG2261	transglycosylase associated protein
XPG1_RS10265	COG1535	isochorismatase
XPG1_RS10265	COG3433	isochorismatase activity
XPG1_RS10270	COG1028	Short-chain dehydrogenase reductase Sdr
XPG1_RS10285	COG1131	(ABC) transporter
XPG1_RS10295	COG3220	belongs to the UPF0276 family
XPG1_RS10310	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
XPG1_RS10325	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
XPG1_RS10330	COG0513	Belongs to the DEAD box helicase family
XPG1_RS10335	COG1309	transcriptional regulator
XPG1_RS10345	COG1131	(ABC) transporter
XPG1_RS10350	COG0842	Transport permease protein
XPG1_RS10355	COG0842	Transport permease protein
XPG1_RS10365	COG0670	Belongs to the BI1 family
XPG1_RS10370	COG0314	molybdopterin synthase activity
XPG1_RS10375	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
XPG1_RS10380	COG0315	cyclic pyranopterin monophosphate synthase activity
XPG1_RS10385	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
XPG1_RS10390	COG0391	Required for morphogenesis under gluconeogenic growth conditions
XPG1_RS10395	COG0556	nucleotide-excision repair
XPG1_RS10405	COG2226	methyltransferase
XPG1_RS10410	COG0156	8-amino-7-oxononanoate synthase activity
XPG1_RS10415	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
XPG1_RS10430	COG2706	6-phosphogluconolactonase activity
XPG1_RS10435	COG0561	phosphatase activity
XPG1_RS10440	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
XPG1_RS10445	COG4149	molybdate abc transporter
XPG1_RS10450	COG0725	ABC transporter, periplasmic molybdate-binding protein
XPG1_RS10460	COG3585	molybdate ion transport
XPG1_RS10460	COG2005	Transcriptional regulator
XPG1_RS10465	COG1119	ATPase activity
XPG1_RS10480	COG0588	phosphoglycerate mutase activity
XPG1_RS10485	COG2801	Transposase and inactivated derivatives
XPG1_RS10490	COG2963	transposase activity
XPG1_RS10495	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
XPG1_RS10510	COG2814	Major facilitator Superfamily
XPG1_RS10515	COG0583	DNA-binding transcription factor activity
XPG1_RS10530	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
XPG1_RS10535	COG2885	chlorophyll binding
XPG1_RS10540	COG0823	Involved in the tonB-independent uptake of proteins
XPG1_RS10545	COG3064	Membrane
XPG1_RS10550	COG0848	biopolymer transport protein
XPG1_RS10555	COG0811	peptide transport
XPG1_RS10560	COG0824	Thioesterase
XPG1_RS10565	COG3790	cyd operon protein YbgE
XPG1_RS10570	COG1294	oxidase, subunit
XPG1_RS10575	COG1271	oxidase subunit
XPG1_RS10580	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
XPG1_RS10585	COG0045	succinate-CoA ligase (ADP-forming) activity
XPG1_RS10590	COG0508	dehydrogenase complex catalyzes the overall conversion of
XPG1_RS10595	COG0567	Dehydrogenase, E1 component
XPG1_RS10600	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
XPG1_RS10605	COG1053	succinate dehydrogenase
XPG1_RS10610	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
XPG1_RS10640	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
XPG1_RS10650	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
XPG1_RS10655	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
XPG1_RS10660	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
XPG1_RS10665	COG2205	protein histidine kinase activity
XPG1_RS10680	COG0033	Phosphoglucomutase
XPG1_RS10685	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
XPG1_RS10690	COG0596	Alpha beta hydrolase
XPG1_RS10695	COG2226	methyltransferase
XPG1_RS10715	COG3064	Membrane
XPG1_RS10715	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
XPG1_RS10715	COG1073	alpha beta
XPG1_RS10720	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
XPG1_RS10720	COG1073	alpha beta
XPG1_RS10720	COG3064	Membrane
XPG1_RS10725	COG2994	toxin metabolic process
XPG1_RS10745	COG2274	protein secretion by the type I secretion system
XPG1_RS10750	COG2207	Transcriptional regulator
XPG1_RS10750	COG1917	Cupin 2, conserved barrel domain protein
XPG1_RS10760	COG0716	FMN binding
XPG1_RS10765	COG0735	belongs to the Fur family
XPG1_RS10770	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
XPG1_RS10805	COG2190	(PTS) system
XPG1_RS10805	COG1263	PTS System
XPG1_RS10805	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
XPG1_RS10810	COG0363	glucosamine-6-phosphate deaminase activity
XPG1_RS10815	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
XPG1_RS10820	COG1940	carbohydrate kinase activity
XPG1_RS10820	COG1846	Transcriptional regulator
XPG1_RS10855	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XPG1_RS10860	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
XPG1_RS10865	COG1702	phosphate starvation-inducible protein PhoH
XPG1_RS10870	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
XPG1_RS10875	COG4535	Mg2 and Co2 transporter CorC
XPG1_RS10880	COG0815	Transfers the fatty acyl group on membrane lipoproteins
XPG1_RS10890	COG0765	amino acid transport
XPG1_RS10895	COG0765	amino acid transport
XPG1_RS10900	COG1126	abc transporter atp-binding protein
XPG1_RS10905	COG0495	leucyl-tRNA aminoacylation
XPG1_RS10910	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
XPG1_RS10915	COG1466	dna polymerase III delta subunit
XPG1_RS10925	COG0799	negative regulation of ribosome biogenesis
XPG1_RS10930	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
XPG1_RS10935	COG0768	penicillin binding
XPG1_RS10940	COG0772	Belongs to the SEDS family
XPG1_RS10945	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
XPG1_RS10950	COG1686	Belongs to the peptidase S11 family
XPG1_RS10955	COG2921	Belongs to the UPF0250 family
XPG1_RS10960	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
XPG1_RS10965	COG0321	lipoyl(octanoyl) transferase activity
XPG1_RS10970	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
XPG1_RS10975	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
XPG1_RS10985	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
XPG1_RS10995	COG4175	Glycine betaine
XPG1_RS11000	COG4176	ABC-type proline glycine betaine transport system permease component
XPG1_RS11005	COG2113	Glycine betaine
XPG1_RS11010	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
XPG1_RS11015	COG1846	Transcriptional regulator
XPG1_RS11020	COG1566	PFAM secretion protein HlyD family protein
XPG1_RS11025	COG2814	Major facilitator Superfamily
XPG1_RS11030	COG4114	ferric iron reductase
XPG1_RS11035	COG1120	ATPase activity
XPG1_RS11045	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
XPG1_RS11050	COG3148	PFAM DTW domain containing protein
XPG1_RS11055	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
XPG1_RS11055	COG1042	CoA-binding domain protein
XPG1_RS11055	COG0045	succinate-CoA ligase (ADP-forming) activity
XPG1_RS11060	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XPG1_RS11085	COG0542	response to heat
XPG1_RS11090	COG1496	oxidoreductase activity
XPG1_RS11095	COG0564	pseudouridine synthase activity
XPG1_RS11100	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XPG1_RS11115	COG0477	Major facilitator Superfamily
XPG1_RS11130	COG0287	Prephenate dehydrogenase
XPG1_RS11130	COG1605	Chorismate mutase
XPG1_RS11135	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
XPG1_RS11140	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
XPG1_RS11145	COG0335	large ribosomal subunit rRNA binding
XPG1_RS11150	COG0336	Belongs to the RNA methyltransferase TrmD family
XPG1_RS11155	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
XPG1_RS11165	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
XPG1_RS11170	COG4137	Cytochrome C assembly protein
XPG1_RS11175	COG4536	flavin adenine dinucleotide binding
XPG1_RS11180	COG2918	glutathione biosynthetic process
XPG1_RS11205	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
XPG1_RS11210	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
XPG1_RS11225	COG2814	Major facilitator Superfamily
XPG1_RS11230	COG0318	PFAM AMP-dependent synthetase and ligase
XPG1_RS11230	COG0204	Acyl-transferase
XPG1_RS11235	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
XPG1_RS11240	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
XPG1_RS11245	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
XPG1_RS11255	COG1073	alpha beta
XPG1_RS11260	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
XPG1_RS11270	COG2195	Cleaves the N-terminal amino acid of tripeptides
XPG1_RS11275	COG2814	Major facilitator Superfamily
XPG1_RS11280	COG0583	DNA-binding transcription factor activity
XPG1_RS11300	COG1629	transport
XPG1_RS11305	COG1595	DNA-templated transcription, initiation
XPG1_RS11310	COG2991	Protein conserved in bacteria
XPG1_RS11315	COG1477	protein flavinylation
XPG1_RS11325	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
XPG1_RS11330	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
XPG1_RS11335	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
XPG1_RS11340	COG1805	sodium ion transport
XPG1_RS11345	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
XPG1_RS11350	COG3034	peptidoglycan biosynthetic process
XPG1_RS11355	COG0121	glutamine amidotransferase
XPG1_RS11360	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
XPG1_RS11365	COG1960	acyl-CoA dehydrogenase activity
XPG1_RS11375	COG0583	DNA-binding transcription factor activity
XPG1_RS11380	COG0583	DNA-binding transcription factor activity
XPG1_RS11395	COG1385	rRNA (uridine-N3-)-methyltransferase activity
XPG1_RS11400	COG0189	ligase activity
XPG1_RS11405	COG1678	Uncharacterized ACR, COG1678
XPG1_RS11410	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
XPG1_RS11415	COG2805	Type II/IV secretion system protein
XPG1_RS11420	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
XPG1_RS11425	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
XPG1_RS11430	COG0762	integral membrane protein
XPG1_RS11435	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
XPG1_RS11440	COG0635	Involved in the biosynthesis of porphyrin-containing compound
XPG1_RS11445	COG0066	3-isopropylmalate dehydratase activity
XPG1_RS11450	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
XPG1_RS11465	COG1881	PFAM PEBP family protein
XPG1_RS11470	COG4607	ABC-type enterochelin transport system periplasmic component
XPG1_RS11480	COG2066	Belongs to the glutaminase family
XPG1_RS11485	COG3171	Protein conserved in bacteria
XPG1_RS11490	COG0220	tRNA (guanine-N7-)-methyltransferase activity
XPG1_RS11495	COG1194	a g-specific adenine glycosylase
XPG1_RS11500	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
XPG1_RS11505	COG0741	lytic transglycosylase activity
XPG1_RS11515	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
XPG1_RS11560	COG2808	Putative FMN-binding domain
XPG1_RS11585	COG1012	belongs to the aldehyde dehydrogenase family
XPG1_RS11590	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
XPG1_RS11645	COG0635	Involved in the biosynthesis of porphyrin-containing compound
XPG1_RS11665	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
XPG1_RS11685	COG1673	EVE domain
XPG1_RS11695	COG2814	Major facilitator Superfamily
XPG1_RS11800	COG3423	Transcriptional regulator
XPG1_RS11830	COG4372	Transposase
XPG1_RS11840	COG3385	transposase activity
XPG1_RS11865	COG4974	Belongs to the 'phage' integrase family
XPG1_RS11950	COG2226	methyltransferase
XPG1_RS11990	COG0583	DNA-binding transcription factor activity
XPG1_RS11995	COG0667	Aldo Keto reductase
XPG1_RS12000	COG2814	Major facilitator Superfamily
XPG1_RS12005	COG1733	regulation of RNA biosynthetic process
XPG1_RS12010	COG0604	alcohol dehydrogenase
XPG1_RS12020	COG3210	domain, Protein
XPG1_RS12030	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
XPG1_RS12045	COG2963	transposase activity
XPG1_RS12050	COG3210	domain, Protein
XPG1_RS12085	COG4221	oxidoreductase activity
XPG1_RS12095	COG2801	Transposase and inactivated derivatives
XPG1_RS12100	COG2963	transposase activity
XPG1_RS12110	COG0583	DNA-binding transcription factor activity
XPG1_RS12135	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
XPG1_RS12155	COG2814	Major facilitator Superfamily
XPG1_RS12160	COG1309	transcriptional regulator
XPG1_RS12185	COG0477	Major facilitator Superfamily
XPG1_RS12210	COG1960	acyl-CoA dehydrogenase activity
XPG1_RS12235	COG2814	Major facilitator Superfamily
XPG1_RS12245	COG1028	Short-chain dehydrogenase reductase Sdr
XPG1_RS12250	COG1028	Short-chain dehydrogenase reductase Sdr
XPG1_RS12260	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
XPG1_RS12265	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
XPG1_RS12270	COG0077	Prephenate dehydratase
XPG1_RS12270	COG1605	Chorismate mutase
XPG1_RS12295	COG0716	FMN binding
XPG1_RS12300	COG0564	pseudouridine synthase activity
XPG1_RS12305	COG3098	single-species biofilm formation
XPG1_RS12315	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
XPG1_RS12315	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
XPG1_RS12320	COG1611	Belongs to the LOG family
XPG1_RS12325	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
XPG1_RS12355	COG2879	small protein
XPG1_RS12360	COG1966	Carbon starvation protein
XPG1_RS12365	COG2194	sulfuric ester hydrolase activity
XPG1_RS12410	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
XPG1_RS12425	COG4942	peptidase
XPG1_RS12425	COG1388	LysM domain
XPG1_RS12430	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
XPG1_RS12435	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
XPG1_RS12440	COG0585	pseudouridine synthase activity
XPG1_RS12445	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
XPG1_RS12475	COG0529	Catalyzes the synthesis of activated sulfate
XPG1_RS12480	COG2895	sulfate adenylyltransferase (ATP) activity
XPG1_RS12485	COG0175	sulfate reduction
XPG1_RS12490	COG1648	precorrin-2 dehydrogenase activity
XPG1_RS12490	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
XPG1_RS12495	COG0175	sulfate reduction
XPG1_RS12500	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
XPG1_RS12505	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
XPG1_RS12510	COG0720	synthase
XPG1_RS12515	COG0602	queuosine metabolic process
XPG1_RS12525	COG3021	interspecies interaction between organisms
XPG1_RS12560	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
XPG1_RS12565	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
XPG1_RS12575	COG1464	Belongs to the NlpA lipoprotein family
XPG1_RS12585	COG1720	tRNA m6t6A37 methyltransferase activity
XPG1_RS12590	COG0442	prolyl-tRNA aminoacylation
XPG1_RS12595	COG4568	rho-dependent transcription termination
XPG1_RS12600	COG0488	(ABC) transporter
XPG1_RS12615	COG0741	lytic transglycosylase activity
XPG1_RS12620	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
XPG1_RS12625	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
XPG1_RS12630	COG0406	alpha-ribazole phosphatase activity
XPG1_RS12635	COG2207	Transcriptional regulator
XPG1_RS12635	COG3708	Transcriptional regulator
XPG1_RS12640	COG3045	CreA protein
XPG1_RS12645	COG0745	RESPONSE REGULATOR receiver
XPG1_RS12655	COG0083	homoserine kinase activity
XPG1_RS12665	COG3022	response to hydroperoxide
XPG1_RS12670	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
XPG1_RS12675	COG0521	Mo-molybdopterin cofactor biosynthetic process
XPG1_RS12685	COG1584	GPR1 FUN34 yaaH family protein
XPG1_RS12690	COG0443	Heat shock 70 kDa protein
XPG1_RS12695	COG0484	heat shock protein binding
XPG1_RS12710	COG2814	Major facilitator Superfamily
XPG1_RS12715	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
XPG1_RS12720	COG0583	DNA-binding transcription factor activity
XPG1_RS12730	COG0196	riboflavin kinase activity
XPG1_RS12735	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
XPG1_RS12740	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
XPG1_RS12745	COG1047	Peptidyl-prolyl cis-trans
XPG1_RS12750	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
XPG1_RS12755	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
XPG1_RS12765	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
XPG1_RS12785	COG3121	Chaperone
XPG1_RS12790	COG3188	usher protein
XPG1_RS12800	COG0813	purine-nucleoside phosphorylase activity
XPG1_RS12805	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
XPG1_RS12810	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
XPG1_RS12815	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
XPG1_RS12820	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
XPG1_RS12825	COG0084	hydrolase, TatD family'
XPG1_RS12830	COG4667	esterase of the alpha-beta hydrolase superfamily
XPG1_RS12835	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
XPG1_RS12845	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
XPG1_RS12850	COG2813	Specifically methylates the guanine in position
XPG1_RS12865	COG1785	Belongs to the alkaline phosphatase family
XPG1_RS12885	COG3423	Transcriptional regulator
XPG1_RS12890	COG2076	Multidrug Resistance protein
XPG1_RS12895	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
XPG1_RS12900	COG1509	lysine 2,3-aminomutase activity
XPG1_RS12910	COG0459	protein refolding
XPG1_RS12925	COG1027	Aspartate ammonia-lyase
XPG1_RS12945	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
XPG1_RS12950	COG4232	protein-disulfide reductase activity
XPG1_RS12955	COG1309	transcriptional regulator
XPG1_RS12965	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
XPG1_RS13015	COG3547	Transposase (IS116 IS110 IS902 family)
XPG1_RS13105	COG4372	Transposase
XPG1_RS13155	COG3423	Transcriptional regulator
XPG1_RS13255	COG2814	Major facilitator Superfamily
XPG1_RS13265	COG1309	transcriptional regulator
XPG1_RS13270	COG2814	Major facilitator Superfamily
XPG1_RS13280	COG0037	tRNA processing
XPG1_RS13285	COG0697	spore germination
XPG1_RS13290	COG0825	malonyl-CoA metabolic process
XPG1_RS13300	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
XPG1_RS13305	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XPG1_RS13310	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XPG1_RS13315	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
XPG1_RS13320	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XPG1_RS13335	COG0750	zinc metalloprotease
XPG1_RS13340	COG0575	Belongs to the CDS family
XPG1_RS13345	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
XPG1_RS13350	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
XPG1_RS13355	COG0233	cytoplasmic translational termination
XPG1_RS13360	COG0528	UMP kinase activity
XPG1_RS13365	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
XPG1_RS13370	COG0052	Belongs to the universal ribosomal protein uS2 family
XPG1_RS13380	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
XPG1_RS13390	COG1126	abc transporter atp-binding protein
XPG1_RS13400	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
XPG1_RS13405	COG0560	Phosphoserine phosphatase
XPG1_RS13410	COG3726	membrane protein affecting hemolysin expression
XPG1_RS13415	COG0656	L-ascorbic acid biosynthetic process
XPG1_RS13440	COG0848	biopolymer transport protein
XPG1_RS13450	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
XPG1_RS13455	COG2974	May be involved in recombination
XPG1_RS13460	COG1940	carbohydrate kinase activity
XPG1_RS13465	COG0737	Belongs to the 5'-nucleotidase family
XPG1_RS13475	COG2132	Multicopper oxidase
XPG1_RS13480	COG0204	Acyl-transferase
XPG1_RS13485	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
XPG1_RS13495	COG3150	esterase
XPG1_RS13500	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
XPG1_RS13505	COG0494	nUDIX hydrolase
XPG1_RS13510	COG1538	Outer membrane efflux protein
XPG1_RS13515	COG5463	Belongs to the UPF0441 family
XPG1_RS13520	COG0754	glutathionylspermidine amidase activity
XPG1_RS13525	COG3384	dioxygenase
XPG1_RS13530	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
XPG1_RS13545	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
XPG1_RS13545	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
XPG1_RS13550	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
XPG1_RS13555	COG3025	triphosphatase activity
XPG1_RS13560	COG4991	sh3 domain protein
XPG1_RS13565	COG0617	tRNA 3'-terminal CCA addition
XPG1_RS13570	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
XPG1_RS13575	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
XPG1_RS13585	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
XPG1_RS13590	COG0828	Belongs to the bacterial ribosomal protein bS21 family
XPG1_RS13595	COG0358	DNA primase activity
XPG1_RS13610	COG1598	PFAM Uncharacterised protein family UPF0150
XPG1_RS13615	COG1724	mRNA binding
XPG1_RS13635	COG0215	cysteine-tRNA ligase activity
XPG1_RS13640	COG1396	sequence-specific DNA binding
XPG1_RS13645	COG1929	Belongs to the glycerate kinase type-1 family
XPG1_RS13655	COG2177	Part of the ABC transporter FtsEX involved in
XPG1_RS13660	COG2884	Cell division ATP-binding protein ftsE
XPG1_RS13665	COG0552	protein localization to endoplasmic reticulum
XPG1_RS13665	COG0552	protein localization to endoplasmic reticulum
XPG1_RS13670	COG0742	ribosomal rna small subunit methyltransferase
XPG1_RS13675	COG3776	membrane
XPG1_RS13685	COG0425	Belongs to the sulfur carrier protein TusA family
XPG1_RS13690	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
XPG1_RS13710	COG2271	Major facilitator Superfamily
XPG1_RS13715	COG0584	glycerophosphoryl diester phosphodiesterase
XPG1_RS13720	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
XPG1_RS13725	COG1053	succinate dehydrogenase
XPG1_RS13730	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
XPG1_RS13735	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
XPG1_RS13740	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
XPG1_RS13750	COG4770	biotin carboxylase activity
XPG1_RS13760	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
XPG1_RS13765	COG1914	H( )-stimulated, divalent metal cation uptake system
XPG1_RS13800	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
XPG1_RS13810	COG1739	Uncharacterized protein family UPF0029
XPG1_RS13815	COG0006	proline dipeptidase activity
XPG1_RS13820	COG1024	Enoyl-CoA hydratase
XPG1_RS13820	COG1250	3-hydroxyacyl-CoA dehydrogenase
XPG1_RS13825	COG0183	Belongs to the thiolase family
XPG1_RS13835	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
XPG1_RS13850	COG0805	protein transport
XPG1_RS13855	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
XPG1_RS13860	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
XPG1_RS13865	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
XPG1_RS13870	COG3165	ubiquinone biosynthetic process from chorismate
XPG1_RS13875	COG2226	methyltransferase
XPG1_RS13885	COG0586	Pfam SNARE associated Golgi protein
XPG1_RS13900	COG2610	gluconate transmembrane transporter activity
XPG1_RS13920	COG3609	addiction module antidote protein, CC2985 family
XPG1_RS13950	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
XPG1_RS13955	COG0583	DNA-binding transcription factor activity
XPG1_RS13960	COG0025	NhaP-type Na H and K H
XPG1_RS13965	COG2252	PERMEase
XPG1_RS13985	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
XPG1_RS14000	COG1448	Aminotransferase
XPG1_RS14025	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
XPG1_RS14030	COG0735	belongs to the Fur family
XPG1_RS14040	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
XPG1_RS14045	COG2937	Belongs to the GPAT DAPAT family
XPG1_RS14050	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
XPG1_RS14055	COG3161	chorismate lyase activity
XPG1_RS14060	COG0166	Belongs to the GPI family
XPG1_RS14065	COG0527	aspartate kinase activity
XPG1_RS14075	COG0800	Aldolase
XPG1_RS14080	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
XPG1_RS14085	COG2224	Isocitrate lyase
XPG1_RS14090	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
XPG1_RS14095	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
XPG1_RS14125	COG0138	bifunctional purine biosynthesis protein purh
XPG1_RS14130	COG0151	Belongs to the GarS family
XPG1_RS14150	COG1515	deoxyribonuclease V activity
XPG1_RS14155	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
XPG1_RS14160	COG2816	NAD+ diphosphatase activity
XPG1_RS14165	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
XPG1_RS14170	COG0352	thiamine-phosphate diphosphorylase activity
XPG1_RS14175	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
XPG1_RS14180	COG2104	thiamine diphosphate biosynthetic process
XPG1_RS14185	COG2022	thiamine diphosphate biosynthetic process
XPG1_RS14200	COG2223	nitrite transmembrane transporter activity
XPG1_RS14205	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
XPG1_RS14215	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
XPG1_RS14220	COG2909	trisaccharide binding
XPG1_RS14225	COG0058	SHG alpha-glucan phosphorylase activity
XPG1_RS14230	COG1640	4-alpha-glucanotransferase
XPG1_RS14235	COG3833	ABC-type maltose transport systems, permease component
XPG1_RS14240	COG1175	transmembrane transport
XPG1_RS14245	COG2182	Extracellular solute-binding protein
XPG1_RS14250	COG3842	ATPase activity
XPG1_RS14255	COG4580	involved in the transport of maltose and maltodextrins
XPG1_RS14265	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
XPG1_RS14270	COG0085	RNA polymerase activity
XPG1_RS14275	COG0222	ribosome binding
XPG1_RS14280	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
XPG1_RS14285	COG0081	regulation of translation
XPG1_RS14290	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
XPG1_RS14295	COG0250	Participates in transcription elongation, termination and antitermination
XPG1_RS14305	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
XPG1_RS14310	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
XPG1_RS14315	COG0049	tRNA binding
XPG1_RS14320	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
XPG1_RS14325	COG2168	tRNA wobble position uridine thiolation
XPG1_RS14330	COG2923	Belongs to the DsrF TusC family
XPG1_RS14335	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
XPG1_RS14340	COG2964	Protein conserved in bacteria
XPG1_RS14345	COG0545	Peptidyl-prolyl cis-trans isomerase
XPG1_RS14350	COG2900	Belongs to the SlyX family
XPG1_RS14355	COG1047	Peptidyl-prolyl cis-trans
XPG1_RS14360	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
XPG1_RS14365	COG0488	(ABC) transporter
XPG1_RS14370	COG0583	DNA-binding transcription factor activity
XPG1_RS14375	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
XPG1_RS14385	COG3089	Belongs to the UPF0270 family
XPG1_RS14390	COG3954	Phosphoribulokinase
XPG1_RS14395	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
XPG1_RS14405	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
XPG1_RS14415	COG0218	Necessary for normal cell division and for the maintenance of normal septation
XPG1_RS14420	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
XPG1_RS14420	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
XPG1_RS14430	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
XPG1_RS14435	COG3084	Protein conserved in bacteria
XPG1_RS14445	COG1763	Mo-molybdopterin cofactor biosynthetic process
XPG1_RS14455	COG0697	spore germination
XPG1_RS14460	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
XPG1_RS14465	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
XPG1_RS14520	COG3547	Transposase (IS116 IS110 IS902 family)
XPG1_RS14535	COG4372	Transposase
XPG1_RS14555	COG4974	Belongs to the 'phage' integrase family
XPG1_RS14560	COG0358	DNA primase activity
XPG1_RS14565	COG2932	Transcriptional regulator
XPG1_RS14580	COG3209	COG3209 Rhs family protein
XPG1_RS14580	COG4104	PAAR repeat-containing protein
XPG1_RS14595	COG3501	Rhs element vgr protein
XPG1_RS14600	COG2175	clavaminate synthase activity
XPG1_RS14615	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
XPG1_RS14620	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
XPG1_RS14625	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
XPG1_RS14630	COG0494	nUDIX hydrolase
XPG1_RS14635	COG4143	(ABC) transporter
XPG1_RS14640	COG1178	ABC-type Fe3 transport system permease component
XPG1_RS14645	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
XPG1_RS14660	COG5433	transposase activity
XPG1_RS14670	COG2990	Protein conserved in bacteria
XPG1_RS14680	COG1902	pentaerythritol trinitrate reductase activity
XPG1_RS14680	COG0446	pyridine nucleotide-disulphide oxidoreductase
XPG1_RS14685	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
XPG1_RS14690	COG0586	Pfam SNARE associated Golgi protein
XPG1_RS14700	COG2814	Major facilitator Superfamily
XPG1_RS14715	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
XPG1_RS14720	COG0673	inositol 2-dehydrogenase activity
XPG1_RS14730	COG4575	ribosome binding
XPG1_RS14735	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
XPG1_RS14745	COG2259	Doxx family
XPG1_RS14750	COG0583	DNA-binding transcription factor activity
XPG1_RS14755	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
XPG1_RS14765	COG0792	nuclease activity
XPG1_RS14770	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
XPG1_RS14775	COG2823	Periplasmic or secreted lipoprotein
XPG1_RS14780	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
XPG1_RS14785	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
XPG1_RS14790	COG2198	Histidine kinase
XPG1_RS14790	COG5002	protein histidine kinase activity
XPG1_RS14790	COG0784	Response regulator, receiver
XPG1_RS14795	COG0070	glutamate synthase
XPG1_RS14795	COG0069	glutamate synthase activity
XPG1_RS14795	COG0067	glutamate synthase
XPG1_RS14800	COG0493	'glutamate synthase
XPG1_RS14810	COG2969	positive regulation of protein catabolic process
XPG1_RS14815	COG0625	glutathione transferase activity
XPG1_RS14820	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
XPG1_RS14825	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
XPG1_RS14830	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
XPG1_RS14835	COG3105	Protein conserved in bacteria
XPG1_RS14840	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
XPG1_RS14845	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
XPG1_RS14850	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
XPG1_RS14855	COG5007	Belongs to the BolA IbaG family
XPG1_RS14865	COG2854	intermembrane phospholipid transfer
XPG1_RS14870	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
XPG1_RS14875	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
XPG1_RS14880	COG1127	ABC transporter
XPG1_RS14885	COG0530	calcium, potassium:sodium antiporter activity
XPG1_RS14890	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
XPG1_RS14890	COG0517	IMP dehydrogenase activity
XPG1_RS14895	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
XPG1_RS14900	COG3117	lipopolysaccharide transmembrane transporter activity
XPG1_RS14905	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
XPG1_RS14910	COG1137	ATPase activity
XPG1_RS14915	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
XPG1_RS14925	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
XPG1_RS14930	COG1660	Displays ATPase and GTPase activities
XPG1_RS14935	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
XPG1_RS14950	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
XPG1_RS14955	COG0312	modulator of DNA gyrase
XPG1_RS14960	COG3028	Belongs to the UPF0307 family
XPG1_RS14995	COG0312	modulator of DNA gyrase
XPG1_RS15000	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
XPG1_RS15005	COG3164	Protein of unknown function
XPG1_RS15010	COG1530	ribonuclease E activity
XPG1_RS15015	COG0424	maF-like protein
XPG1_RS15020	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
XPG1_RS15025	COG1792	Involved in formation and maintenance of cell shape
XPG1_RS15030	COG1077	Cell shape determining protein MreB Mrl
XPG1_RS15035	COG0604	alcohol dehydrogenase
XPG1_RS15040	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
XPG1_RS15045	COG0511	ligase activity, forming carbon-carbon bonds
XPG1_RS15050	COG0439	Biotin carboxylase
XPG1_RS15055	COG3924	membrane
XPG1_RS15060	COG4145	pantothenate transmembrane transporter activity
XPG1_RS15065	COG2264	protein methyltransferase activity
XPG1_RS15070	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
XPG1_RS15075	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
XPG1_RS15085	COG0477	Major facilitator Superfamily
XPG1_RS15105	COG0583	DNA-binding transcription factor activity
XPG1_RS15110	COG1470	cell adhesion involved in biofilm formation
XPG1_RS15110	COG1388	LysM domain
XPG1_RS15115	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XPG1_RS15130	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
XPG1_RS15155	COG0765	amino acid transport
XPG1_RS15160	COG1126	abc transporter atp-binding protein
XPG1_RS15165	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
XPG1_RS15170	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
XPG1_RS15175	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
XPG1_RS15180	COG0626	cystathionine gamma-synthase activity
XPG1_RS15185	COG1757	Na H antiporter
XPG1_RS15190	COG2515	1-aminocyclopropane-1-carboxylate deaminase
XPG1_RS15205	COG1846	Transcriptional regulator
XPG1_RS15210	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
XPG1_RS15215	COG0564	pseudouridine synthase activity
XPG1_RS15220	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
XPG1_RS15225	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
XPG1_RS15230	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
XPG1_RS15235	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
XPG1_RS15240	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
XPG1_RS15245	COG2967	ApaG domain
XPG1_RS15250	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
XPG1_RS15255	COG0513	Belongs to the DEAD box helicase family
XPG1_RS15270	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
XPG1_RS15275	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
XPG1_RS15280	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
XPG1_RS15285	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
XPG1_RS15290	COG0195	Participates in both transcription termination and antitermination
XPG1_RS15295	COG0779	Required for maturation of 30S ribosomal subunits
XPG1_RS15310	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
XPG1_RS15315	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
XPG1_RS15320	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
XPG1_RS15330	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
XPG1_RS15335	COG1534	Rna-binding protein
XPG1_RS15345	COG2027	D-alanyl-D-alanine carboxypeptidase
XPG1_RS15350	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
XPG1_RS15355	COG0211	Belongs to the bacterial ribosomal protein bL27 family
XPG1_RS15360	COG0261	This protein binds to 23S rRNA in the presence of protein L20
XPG1_RS15365	COG0142	geranyltranstransferase activity
XPG1_RS15380	COG3423	Transcriptional regulator
XPG1_RS15385	COG0039	L-malate dehydrogenase activity
XPG1_RS15395	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
XPG1_RS15400	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
XPG1_RS15420	COG2105	PFAM AIG2 family protein
XPG1_RS15425	COG2911	Protein conserved in bacteria
XPG1_RS15435	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
XPG1_RS15440	COG1253	flavin adenine dinucleotide binding
XPG1_RS15450	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
XPG1_RS15460	COG0545	Peptidyl-prolyl cis-trans isomerase
XPG1_RS15465	COG0359	binds to the 23S rRNA
XPG1_RS15470	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
XPG1_RS15475	COG2965	DNA replication, synthesis of RNA primer
XPG1_RS15480	COG0360	Binds together with S18 to 16S ribosomal RNA
XPG1_RS15485	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
XPG1_RS15490	COG0557	exoribonuclease II activity
XPG1_RS15495	COG1959	2 iron, 2 sulfur cluster binding
XPG1_RS15500	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
XPG1_RS15505	COG0330	HflC and HflK could
XPG1_RS15510	COG0330	HflC and HflK could
XPG1_RS15515	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
XPG1_RS15520	COG1923	regulation of RNA biosynthetic process
XPG1_RS15525	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
XPG1_RS15530	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
XPG1_RS15535	COG0860	N-Acetylmuramoyl-L-alanine amidase
XPG1_RS15540	COG0802	atpase or kinase
XPG1_RS15545	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
XPG1_RS15570	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
XPG1_RS15575	COG1162	GTPase activity
XPG1_RS15580	COG0688	phosphatidylethanolamine metabolic process
XPG1_RS15585	COG1511	domain protein
XPG1_RS15585	COG3264	Mechanosensitive ion channel
XPG1_RS15590	COG0561	phosphatase activity
XPG1_RS15595	COG2267	carboxylic ester hydrolase activity
XPG1_RS15600	COG0514	ATP-dependent DNA helicase (RecQ)
XPG1_RS15605	COG2050	protein possibly involved in aromatic compounds catabolism
XPG1_RS15620	COG2814	Major facilitator Superfamily
XPG1_RS15625	COG0583	DNA-binding transcription factor activity
XPG1_RS15635	COG0598	Magnesium transport protein CorA
XPG1_RS15645	COG1011	Hydrolase
XPG1_RS15660	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
XPG1_RS15670	COG1965	Belongs to the frataxin family
XPG1_RS15680	COG0181	hydroxymethylbilane synthase activity
XPG1_RS15690	COG2959	enzyme of heme biosynthesis
XPG1_RS15695	COG3071	HemY protein
XPG1_RS15725	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
XPG1_RS15735	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
XPG1_RS15740	COG2244	polysaccharide biosynthetic process
XPG1_RS15745	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
XPG1_RS15750	COG0456	acetyltransferase
XPG1_RS15755	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
XPG1_RS15760	COG1088	dTDP-glucose 4,6-dehydratase activity
XPG1_RS15765	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
XPG1_RS15770	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
XPG1_RS15775	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
XPG1_RS15780	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
XPG1_RS15785	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
XPG1_RS15790	COG3118	belongs to the thioredoxin family
XPG1_RS15795	COG0513	Belongs to the DEAD box helicase family
XPG1_RS15800	COG0248	Ppx GppA phosphatase
XPG1_RS15810	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
XPG1_RS15825	COG0129	dihydroxy-acid dehydratase activity
XPG1_RS15835	COG3978	acetolactate synthase activity
XPG1_RS15845	COG0606	chelatase, subunit chli
XPG1_RS15850	COG3085	chromosome segregation
XPG1_RS15855	COG0583	DNA-binding transcription factor activity
XPG1_RS15890	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
XPG1_RS15900	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
XPG1_RS15905	COG0009	L-threonylcarbamoyladenylate synthase
XPG1_RS15910	COG0551	DNA topoisomerase type I activity
XPG1_RS15915	COG0758	DNA mediated transformation
XPG1_RS15925	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
XPG1_RS15930	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
XPG1_RS15930	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
XPG1_RS15935	COG0569	domain protein
XPG1_RS15945	COG3036	rescue of stalled ribosome
XPG1_RS15950	COG0789	Transcriptional regulator
XPG1_RS15955	COG0203	ribosomal protein L17
XPG1_RS15960	COG0202	RNA polymerase activity
XPG1_RS15965	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
XPG1_RS15975	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
XPG1_RS15980	COG0257	Belongs to the bacterial ribosomal protein bL36 family
XPG1_RS15985	COG0201	protein transport
XPG1_RS15990	COG0200	Binds to the 23S rRNA
XPG1_RS15995	COG1841	ribosomal large subunit assembly
XPG1_RS16000	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
XPG1_RS16005	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
XPG1_RS16010	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
XPG1_RS16015	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
XPG1_RS16020	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
XPG1_RS16025	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
XPG1_RS16030	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
XPG1_RS16035	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
XPG1_RS16040	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
XPG1_RS16050	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
XPG1_RS16065	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
XPG1_RS16070	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
XPG1_RS16075	COG0089	rRNA binding
XPG1_RS16080	COG0088	Forms part of the polypeptide exit tunnel
XPG1_RS16085	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
XPG1_RS16090	COG0051	transcription antitermination factor activity, RNA binding
XPG1_RS16105	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
XPG1_RS16135	COG1072	(Pantothenic acid kinase))
XPG1_RS16140	COG2801	Transposase and inactivated derivatives
XPG1_RS16145	COG2963	transposase activity
XPG1_RS16155	COG0812	UDP-N-acetylmuramate dehydrogenase activity
XPG1_RS16195	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
XPG1_RS16200	COG4206	TonB-dependent receptor
XPG1_RS16205	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
XPG1_RS16220	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
XPG1_RS16235	COG0165	Argininosuccinate lyase
XPG1_RS16240	COG0137	argininosuccinate synthase activity
XPG1_RS16245	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
XPG1_RS16250	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
XPG1_RS16255	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
XPG1_RS16265	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
XPG1_RS16270	COG0460	homoserine dehydrogenase
XPG1_RS16270	COG0527	aspartate kinase activity
XPG1_RS16275	COG0626	cystathionine gamma-synthase activity
XPG1_RS16280	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
XPG1_RS16290	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
XPG1_RS16295	COG1609	Transcriptional regulator
XPG1_RS16300	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
XPG1_RS16305	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
XPG1_RS16310	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
XPG1_RS16315	COG1575	Belongs to the MenA family. Type 1 subfamily
XPG1_RS16320	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
XPG1_RS16325	COG3074	FtsZ-dependent cytokinesis
XPG1_RS16335	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
XPG1_RS16345	COG3152	Membrane
XPG1_RS16355	COG0149	triose-phosphate isomerase activity
XPG1_RS16360	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
XPG1_RS16365	COG0205	6-phosphofructokinase activity
XPG1_RS16370	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
XPG1_RS16390	COG0745	RESPONSE REGULATOR receiver
XPG1_RS16395	COG2205	protein histidine kinase activity
XPG1_RS16440	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
XPG1_RS16455	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
XPG1_RS16460	COG1045	serine acetyltransferase
XPG1_RS16465	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
XPG1_RS16470	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
XPG1_RS16475	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
XPG1_RS16480	COG4942	peptidase
XPG1_RS16490	COG2861	carbohydrate metabolic process
XPG1_RS16495	COG1063	alcohol dehydrogenase
XPG1_RS16500	COG0156	8-amino-7-oxononanoate synthase activity
XPG1_RS16505	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
XPG1_RS16525	COG0859	PFAM glycosyl transferase family 9
XPG1_RS16535	COG0859	PFAM glycosyl transferase family 9
XPG1_RS16545	COG0438	transferase activity, transferring glycosyl groups
XPG1_RS16545	COG0297	glycogen (starch) synthase activity
XPG1_RS16550	COG1519	Transferase
XPG1_RS16560	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
XPG1_RS16565	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
XPG1_RS16575	COG0438	transferase activity, transferring glycosyl groups
XPG1_RS16585	COG0438	transferase activity, transferring glycosyl groups
XPG1_RS16590	COG0267	Belongs to the bacterial ribosomal protein bL33 family
XPG1_RS16600	COG2003	Belongs to the UPF0758 family
XPG1_RS16610	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
XPG1_RS16615	COG0756	dUTP diphosphatase activity
XPG1_RS16620	COG1309	transcriptional regulator
XPG1_RS16625	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
XPG1_RS16630	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
XPG1_RS16635	COG1561	YicC-like family, N-terminal region
XPG1_RS16640	COG0582	viral genome integration into host DNA
XPG1_RS16650	COG3645	SOS response
XPG1_RS16665	COG3645	SOS response
XPG1_RS16700	COG5433	transposase activity
XPG1_RS16725	COG1368	sulfuric ester hydrolase activity
XPG1_RS16730	COG3276	selenocysteine insertion sequence binding
XPG1_RS16735	COG1921	L-seryl-tRNASec selenium transferase activity
XPG1_RS16740	COG3058	Necessary for formate dehydrogenase activity
XPG1_RS16750	COG0733	neurotransmitter:sodium symporter activity
XPG1_RS16760	COG2864	formate dehydrogenase
XPG1_RS16770	COG0243	molybdopterin cofactor binding
XPG1_RS16770	COG3383	formate dehydrogenase (NAD+) activity
XPG1_RS16780	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
XPG1_RS16790	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
XPG1_RS16830	COG2249	NAD(P)H dehydrogenase (quinone) activity
XPG1_RS16835	COG1028	Short-chain dehydrogenase reductase Sdr
XPG1_RS16840	COG1028	Short-chain dehydrogenase reductase Sdr
XPG1_RS16855	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
XPG1_RS16870	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
XPG1_RS16875	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
XPG1_RS16880	COG0706	membrane insertase activity
XPG1_RS16885	COG0594	ribonuclease P activity
XPG1_RS17045	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
XPG1_RS17050	COG5433	transposase activity
XPG1_RS17100	COG0305	Participates in initiation and elongation during chromosome replication
XPG1_RS17105	COG0305	Participates in initiation and elongation during chromosome replication
XPG1_RS17165	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type