locus-tag	class	description
J7S26_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
J7S26_RS00010	COG0230	Belongs to the bacterial ribosomal protein bL34 family
J7S26_RS00015	COG0594	ribonuclease P activity
J7S26_RS00020	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
J7S26_RS00030	COG1847	R3H domain protein
J7S26_RS00035	COG0357	Ribosomal RNA small subunit methyltransferase G
J7S26_RS00040	COG1192	Involved in chromosome partitioning
J7S26_RS00045	COG1475	DNA binding
J7S26_RS00050	COG3706	GGDEF domain
J7S26_RS00055	COG0820	rRNA (adenine-C2-)-methyltransferase activity
J7S26_RS00060	COG1181	Belongs to the D-alanine--D-alanine ligase family
J7S26_RS00070	COG1199	ATP-dependent helicase activity
J7S26_RS00105	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
J7S26_RS00135	COG1115	amino acid carrier protein
J7S26_RS00140	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
J7S26_RS00145	COG0708	Exodeoxyribonuclease III
J7S26_RS00150	COG0302	gtp cyclohydrolase
J7S26_RS00155	COG3830	Belongs to the UPF0237 family
J7S26_RS00165	COG1970	mechanosensitive ion channel activity
J7S26_RS00170	COG1169	isochorismate synthase
J7S26_RS00175	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
J7S26_RS00180	COG0596	Alpha beta hydrolase
J7S26_RS00185	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
J7S26_RS00205	COG3437	response regulator, receiver
J7S26_RS00215	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
J7S26_RS00220	COG1162	GTPase activity
J7S26_RS00230	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
J7S26_RS00240	COG1592	Rubrerythrin
J7S26_RS00250	COG0436	Aminotransferase
J7S26_RS00270	COG2414	aldehyde ferredoxin oxidoreductase
J7S26_RS00275	COG0437	4 iron, 4 sulfur cluster binding
J7S26_RS00280	COG0243	molybdopterin cofactor binding
J7S26_RS00290	COG3301	Polysulphide reductase, NrfD
J7S26_RS00295	COG1528	Iron-storage protein
J7S26_RS00305	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
J7S26_RS00310	COG0745	RESPONSE REGULATOR receiver
J7S26_RS00315	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
J7S26_RS00320	COG2759	Belongs to the formate--tetrahydrofolate ligase family
J7S26_RS00325	COG3404	Formiminotransferase-cyclodeaminase
J7S26_RS00330	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
J7S26_RS00335	COG3381	protein complex oligomerization
J7S26_RS00340	COG1725	Transcriptional regulator
J7S26_RS00345	COG1131	(ABC) transporter
J7S26_RS00365	COG0497	DNA recombination
J7S26_RS00375	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
J7S26_RS00380	COG0805	protein transport
J7S26_RS00385	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
J7S26_RS00415	COG0864	Transcriptional regulator
J7S26_RS00440	COG0443	Heat shock 70 kDa protein
J7S26_RS00445	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
J7S26_RS00450	COG0484	heat shock protein binding
J7S26_RS00455	COG0789	Transcriptional regulator
J7S26_RS00460	COG0542	response to heat
J7S26_RS00465	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
J7S26_RS00485	COG0745	RESPONSE REGULATOR receiver
J7S26_RS00500	COG5002	protein histidine kinase activity
J7S26_RS00505	COG3328	transposase activity
J7S26_RS00515	COG0583	DNA-binding transcription factor activity
J7S26_RS00530	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
J7S26_RS00550	COG1924	4 iron, 4 sulfur cluster binding
J7S26_RS00585	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
J7S26_RS00595	COG1966	Carbon starvation protein
J7S26_RS00610	COG3956	TIGRFAM MazG family protein
J7S26_RS00615	COG2357	RelA SpoT domain protein
J7S26_RS00635	COG1739	Uncharacterized protein family UPF0029
J7S26_RS00660	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
J7S26_RS00660	COG2205	protein histidine kinase activity
J7S26_RS00665	COG1316	TRANSCRIPTIONal
J7S26_RS00670	COG3620	sequence-specific DNA binding
J7S26_RS00680	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
J7S26_RS00695	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
J7S26_RS00700	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
J7S26_RS00705	COG0668	transmembrane transport
J7S26_RS00715	COG0436	Aminotransferase
J7S26_RS00735	COG1918	ferrous iron import across plasma membrane
J7S26_RS00735	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
J7S26_RS00750	COG3437	response regulator, receiver
J7S26_RS00755	COG2198	Histidine kinase
J7S26_RS00755	COG2205	protein histidine kinase activity
J7S26_RS00755	COG0784	Response regulator, receiver
J7S26_RS00780	COG0142	geranyltranstransferase activity
J7S26_RS00795	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
J7S26_RS00800	COG0066	3-isopropylmalate dehydratase activity
J7S26_RS00810	COG0473	3-isopropylmalate dehydrogenase activity
J7S26_RS00845	COG0124	histidyl-tRNA synthetase
J7S26_RS00850	COG0159	tryptophan synthase activity
J7S26_RS00855	COG0133	tryptophan synthase activity
J7S26_RS00860	COG0134	indole-3-glycerol-phosphate synthase activity
J7S26_RS00870	COG0512	Glutamine amidotransferase of anthranilate synthase
J7S26_RS00880	COG1294	oxidase, subunit
J7S26_RS00885	COG1271	oxidase subunit
J7S26_RS00900	COG1136	(ABC) transporter
J7S26_RS00920	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
J7S26_RS00925	COG0072	phenylalanine-tRNA ligase activity
J7S26_RS00930	COG0024	Methionine aminopeptidase
J7S26_RS00950	COG1086	Polysaccharide biosynthesis protein
J7S26_RS00955	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
J7S26_RS00960	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
J7S26_RS00965	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
J7S26_RS00970	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
J7S26_RS00975	COG1438	arginine binding
J7S26_RS00980	COG0137	argininosuccinate synthase activity
J7S26_RS00985	COG0165	Argininosuccinate lyase
J7S26_RS00990	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
J7S26_RS01000	COG0826	peptidase U32
J7S26_RS01005	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
J7S26_RS01025	COG2508	Transcriptional regulator
J7S26_RS01030	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
J7S26_RS01040	COG0243	molybdopterin cofactor binding
J7S26_RS01045	COG0437	4 iron, 4 sulfur cluster binding
J7S26_RS01060	COG1131	(ABC) transporter
J7S26_RS01100	COG0573	inorganic phosphate transmembrane transporter activity
J7S26_RS01105	COG0581	inorganic phosphate transmembrane transporter activity
J7S26_RS01110	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
J7S26_RS01115	COG0745	RESPONSE REGULATOR receiver
J7S26_RS01120	COG5002	protein histidine kinase activity
J7S26_RS01135	COG0110	maltose O-acetyltransferase activity
J7S26_RS01145	COG0667	Aldo Keto reductase
J7S26_RS01160	COG1940	carbohydrate kinase activity
J7S26_RS01165	COG0785	Cytochrome C biogenesis protein
J7S26_RS01175	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
J7S26_RS01180	COG0765	amino acid transport
J7S26_RS01185	COG1126	abc transporter atp-binding protein
J7S26_RS01195	COG3973	AAA domain
J7S26_RS01220	COG0519	Catalyzes the synthesis of GMP from XMP
J7S26_RS01235	COG5002	protein histidine kinase activity
J7S26_RS01235	COG2205	protein histidine kinase activity
J7S26_RS01235	COG0784	Response regulator, receiver
J7S26_RS01240	COG2826	transposase and inactivated derivatives, IS30 family
J7S26_RS01250	COG1733	regulation of RNA biosynthetic process
J7S26_RS01290	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
J7S26_RS01295	COG3177	Filamentation induced by cAMP protein fic
J7S26_RS01305	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
J7S26_RS01310	COG0243	molybdopterin cofactor binding
J7S26_RS01315	COG0437	4 iron, 4 sulfur cluster binding
J7S26_RS01320	COG0784	Response regulator, receiver
J7S26_RS01320	COG2205	protein histidine kinase activity
J7S26_RS01325	COG0745	RESPONSE REGULATOR receiver
J7S26_RS01335	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
J7S26_RS01340	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
J7S26_RS01350	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
J7S26_RS01360	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
J7S26_RS01370	COG1132	(ABC) transporter
J7S26_RS01375	COG0511	ligase activity, forming carbon-carbon bonds
J7S26_RS01375	COG5016	pyruvate
J7S26_RS01380	COG0439	Biotin carboxylase
J7S26_RS01390	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
J7S26_RS01400	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
J7S26_RS01405	COG0539	negative regulation of cytoplasmic translation
J7S26_RS01410	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
J7S26_RS01410	COG2755	lipolytic protein G-D-S-L family
J7S26_RS01415	COG0482	sulfurtransferase activity
J7S26_RS01420	COG0237	dephospho-CoA kinase activity
J7S26_RS01445	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
J7S26_RS01455	COG0556	nucleotide-excision repair
J7S26_RS01460	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
J7S26_RS01465	COG5002	protein histidine kinase activity
J7S26_RS01465	COG2205	protein histidine kinase activity
J7S26_RS01465	COG0784	Response regulator, receiver
J7S26_RS01470	COG2860	membrane
J7S26_RS01475	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
J7S26_RS01485	COG5002	protein histidine kinase activity
J7S26_RS01485	COG5001	Diguanylate cyclase
J7S26_RS01490	COG0085	RNA polymerase activity
J7S26_RS01495	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
J7S26_RS01530	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
J7S26_RS01535	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
J7S26_RS01540	COG0248	Ppx GppA phosphatase
J7S26_RS01545	COG2326	polyphosphate kinase activity
J7S26_RS01565	COG0343	queuine tRNA-ribosyltransferase activity
J7S26_RS01570	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
J7S26_RS01570	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
J7S26_RS01580	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
J7S26_RS01585	COG1122	ATPase activity
J7S26_RS01590	COG1122	ATPase activity
J7S26_RS01600	COG1115	amino acid carrier protein
J7S26_RS01605	COG1115	amino acid carrier protein
J7S26_RS01610	COG2081	HI0933 family
J7S26_RS01615	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
J7S26_RS01655	COG0698	ribose 5-phosphate isomerase
J7S26_RS01660	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
J7S26_RS01665	COG2131	deaminase
J7S26_RS01675	COG0356	it plays a direct role in the translocation of protons across the membrane
J7S26_RS01685	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
J7S26_RS01695	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
J7S26_RS01700	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
J7S26_RS01705	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
J7S26_RS01710	COG0355	proton-transporting ATP synthase activity, rotational mechanism
J7S26_RS01720	COG0101	tRNA pseudouridine synthase activity
J7S26_RS01730	COG0733	neurotransmitter:sodium symporter activity
J7S26_RS01760	COG0583	DNA-binding transcription factor activity
J7S26_RS01800	COG3976	FMN-binding domain protein
J7S26_RS01800	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
J7S26_RS01805	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
J7S26_RS01815	COG0243	molybdopterin cofactor binding
J7S26_RS01820	COG2197	response regulator
J7S26_RS01830	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
J7S26_RS01835	COG0154	amidase activity
J7S26_RS01840	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
J7S26_RS01850	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
J7S26_RS01855	COG1396	sequence-specific DNA binding
J7S26_RS01860	COG1115	amino acid carrier protein
J7S26_RS01870	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
J7S26_RS01880	COG4149	molybdate abc transporter
J7S26_RS01885	COG3842	ATPase activity
J7S26_RS01890	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
J7S26_RS01895	COG0632	four-way junction helicase activity
J7S26_RS01900	COG2255	four-way junction helicase activity
J7S26_RS01910	COG1278	Cold shock
J7S26_RS01930	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
J7S26_RS01940	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
J7S26_RS01960	COG0542	response to heat
J7S26_RS01965	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
J7S26_RS01975	COG0215	cysteine-tRNA ligase activity
J7S26_RS01980	COG0826	peptidase U32
J7S26_RS02000	COG0402	S-adenosylhomocysteine deaminase activity
J7S26_RS02005	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
J7S26_RS02020	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
J7S26_RS02025	COG0736	holo-[acyl-carrier-protein] synthase activity
J7S26_RS02030	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
J7S26_RS02030	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
J7S26_RS02050	COG1091	dTDP-4-dehydrorhamnose reductase activity
J7S26_RS02060	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
J7S26_RS02065	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
J7S26_RS02070	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
J7S26_RS02075	COG0131	Imidazoleglycerol-phosphate dehydratase
J7S26_RS02080	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
J7S26_RS02090	COG0107	imidazoleglycerol-phosphate synthase activity
J7S26_RS02095	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
J7S26_RS02105	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
J7S26_RS02115	COG0616	signal peptide processing
J7S26_RS02120	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
J7S26_RS02120	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
J7S26_RS02125	COG0328	RNA-DNA hybrid ribonuclease activity
J7S26_RS02145	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
J7S26_RS02155	COG1597	lipid kinase activity
J7S26_RS02160	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
J7S26_RS02165	COG0217	transcriptional regulatory protein
J7S26_RS02175	COG2001	Belongs to the MraZ family
J7S26_RS02180	COG0275	rRNA processing
J7S26_RS02190	COG0768	penicillin binding
J7S26_RS02195	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
J7S26_RS02205	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
J7S26_RS02210	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
J7S26_RS02215	COG0772	Belongs to the SEDS family
J7S26_RS02220	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
J7S26_RS02225	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
J7S26_RS02230	COG0812	UDP-N-acetylmuramate dehydrogenase activity
J7S26_RS02235	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
J7S26_RS02240	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
J7S26_RS02260	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
J7S26_RS02265	COG0762	integral membrane protein
J7S26_RS02290	COG0437	4 iron, 4 sulfur cluster binding
J7S26_RS02295	COG0243	molybdopterin cofactor binding
J7S26_RS02315	COG0426	domain, Protein
J7S26_RS02320	COG2184	nucleotidyltransferase activity
J7S26_RS02355	COG3475	LICD family
J7S26_RS02370	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
J7S26_RS02380	COG1682	transport, permease protein
J7S26_RS02385	COG1134	teichoic acid transport
J7S26_RS02390	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
J7S26_RS02405	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
J7S26_RS02420	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
J7S26_RS02425	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
J7S26_RS02475	COG0180	Tryptophanyl-tRNA synthetase
J7S26_RS02490	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
J7S26_RS02495	COG0513	Belongs to the DEAD box helicase family
J7S26_RS02505	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
J7S26_RS02515	COG0138	bifunctional purine biosynthesis protein purh
J7S26_RS02520	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
J7S26_RS02525	COG1968	undecaprenyl-diphosphatase activity
J7S26_RS02545	COG1077	Cell shape determining protein MreB Mrl
J7S26_RS02550	COG1792	Involved in formation and maintenance of cell shape
J7S26_RS02560	COG0768	penicillin binding
J7S26_RS02565	COG0772	Belongs to the SEDS family
J7S26_RS02595	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
J7S26_RS02600	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
J7S26_RS02605	COG1316	TRANSCRIPTIONal
J7S26_RS02610	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
J7S26_RS02610	COG0316	Belongs to the HesB IscA family
J7S26_RS02620	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
J7S26_RS02625	COG2033	superoxide reductase activity
J7S26_RS02640	COG0254	rRNA binding
J7S26_RS02645	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
J7S26_RS02645	COG1773	rubredoxin
J7S26_RS02650	COG0500	methyltransferase
J7S26_RS02655	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
J7S26_RS02660	COG3872	metal-dependent enzyme
J7S26_RS02670	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
J7S26_RS02675	COG0765	amino acid transport
J7S26_RS02680	COG0765	amino acid transport
J7S26_RS02695	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
J7S26_RS02705	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
J7S26_RS02710	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
J7S26_RS02730	COG1194	a g-specific adenine glycosylase
J7S26_RS02735	COG1971	Probably functions as a manganese efflux pump
J7S26_RS02745	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
J7S26_RS02770	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
J7S26_RS02780	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
J7S26_RS02790	COG0488	(ABC) transporter
J7S26_RS02800	COG0583	DNA-binding transcription factor activity
J7S26_RS02805	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
J7S26_RS02810	COG1994	Peptidase M50
J7S26_RS02820	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
J7S26_RS02825	COG1187	pseudouridine synthase activity
J7S26_RS02830	COG0287	Prephenate dehydrogenase
J7S26_RS02845	COG0204	Acyl-transferase
J7S26_RS02850	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
J7S26_RS02860	COG1160	GTP binding
J7S26_RS02865	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
J7S26_RS02870	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
J7S26_RS02875	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
J7S26_RS02880	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
J7S26_RS02890	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
J7S26_RS02905	COG1216	Glycosyl transferase, family 2
J7S26_RS02910	COG1215	transferase activity, transferring glycosyl groups
J7S26_RS02915	COG1316	TRANSCRIPTIONal
J7S26_RS02920	COG1316	TRANSCRIPTIONal
J7S26_RS02925	COG1216	Glycosyl transferase, family 2
J7S26_RS02930	COG1215	transferase activity, transferring glycosyl groups
J7S26_RS02935	COG1301	dicarboxylic acid transport
J7S26_RS02950	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
J7S26_RS02965	COG0674	pyruvate-flavodoxin oxidoreductase activity
J7S26_RS02985	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
J7S26_RS02990	COG2116	formate transmembrane transporter activity
J7S26_RS03005	COG0475	glutathione-regulated potassium exporter activity
J7S26_RS03030	COG0515	serine threonine protein kinase
J7S26_RS03080	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
J7S26_RS03175	COG1783	phage Terminase large subunit
J7S26_RS03255	COG1476	TRANSCRIPTIONal
J7S26_RS03270	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
J7S26_RS03280	COG2814	Major facilitator Superfamily
J7S26_RS03305	COG3328	transposase activity
J7S26_RS03315	COG0326	Molecular chaperone. Has ATPase activity
J7S26_RS03335	COG1881	PFAM PEBP family protein
J7S26_RS03340	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
J7S26_RS03350	COG0544	peptidyl-prolyl cis-trans isomerase activity
J7S26_RS03355	COG0740	serine-type endopeptidase activity
J7S26_RS03360	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
J7S26_RS03365	COG0525	valine-tRNA ligase activity
J7S26_RS03375	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
J7S26_RS03390	COG0105	UTP biosynthetic process
J7S26_RS03400	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
J7S26_RS03410	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
J7S26_RS03420	COG0779	Required for maturation of 30S ribosomal subunits
J7S26_RS03425	COG0195	Participates in both transcription termination and antitermination
J7S26_RS03435	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
J7S26_RS03440	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
J7S26_RS03465	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
J7S26_RS03470	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
J7S26_RS03480	COG0322	excinuclease ABC activity
J7S26_RS03485	COG1660	Displays ATPase and GTPase activities
J7S26_RS03490	COG0391	Required for morphogenesis under gluconeogenic growth conditions
J7S26_RS03495	COG1481	regulation of sporulation
J7S26_RS03500	COG0227	Belongs to the bacterial ribosomal protein bL28 family
J7S26_RS03505	COG1302	Protein conserved in bacteria
J7S26_RS03510	COG1461	Dihydroxyacetone kinase
J7S26_RS03515	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
J7S26_RS03520	COG0742	ribosomal rna small subunit methyltransferase
J7S26_RS03540	COG0333	Belongs to the bacterial ribosomal protein bL32 family
J7S26_RS03545	COG0416	fatty acid biosynthetic process
J7S26_RS03550	COG0571	ribonuclease III activity
J7S26_RS03555	COG1196	nuclear chromosome segregation
J7S26_RS03560	COG0552	protein localization to endoplasmic reticulum
J7S26_RS03565	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
J7S26_RS03575	COG1335	isochorismatase
J7S26_RS03595	COG0129	dihydroxy-acid dehydratase activity
J7S26_RS03600	COG0028	Belongs to the TPP enzyme family
J7S26_RS03605	COG0440	acetolactate synthase activity
J7S26_RS03610	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
J7S26_RS03615	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
J7S26_RS03620	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
J7S26_RS03640	COG1216	Glycosyl transferase, family 2
J7S26_RS03690	COG0437	4 iron, 4 sulfur cluster binding
J7S26_RS03715	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
J7S26_RS03725	COG0456	acetyltransferase
J7S26_RS03740	COG3093	addiction module antidote protein HigA
J7S26_RS03745	COG4134	Bacterial extracellular solute-binding protein
J7S26_RS03750	COG1176	ABC-type spermidine putrescine transport system, permease component I
J7S26_RS03755	COG1177	transmembrane transport
J7S26_RS03760	COG3842	ATPase activity
J7S26_RS03785	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
J7S26_RS03790	COG2738	Putative neutral zinc metallopeptidase
J7S26_RS03795	COG1570	exodeoxyribonuclease VII activity
J7S26_RS03800	COG1722	exodeoxyribonuclease VII activity
J7S26_RS03805	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
J7S26_RS03820	COG0335	large ribosomal subunit rRNA binding
J7S26_RS03830	COG0792	nuclease activity
J7S26_RS03845	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
J7S26_RS03850	COG4974	Belongs to the 'phage' integrase family
J7S26_RS03865	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
J7S26_RS03895	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
J7S26_RS03900	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
J7S26_RS03915	COG1381	Involved in DNA repair and RecF pathway recombination
J7S26_RS03925	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
J7S26_RS03930	COG1185	polyribonucleotide nucleotidyltransferase activity
J7S26_RS03935	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
J7S26_RS03940	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
J7S26_RS03945	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
J7S26_RS03960	COG1666	GTP binding
J7S26_RS03965	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
J7S26_RS03970	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
J7S26_RS03975	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
J7S26_RS03980	COG2137	regulation of response to DNA damage stimulus
J7S26_RS03985	COG2217	Heavy metal translocating P-type atpase
J7S26_RS03995	COG0640	Transcriptional regulator
J7S26_RS04000	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
J7S26_RS04005	COG0540	Belongs to the ATCase OTCase family
J7S26_RS04010	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
J7S26_RS04015	COG3695	enzyme binding
J7S26_RS04020	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
J7S26_RS04025	COG0543	2 iron, 2 sulfur cluster binding
J7S26_RS04030	COG0167	dihydroorotate dehydrogenase activity
J7S26_RS04035	COG0284	orotidine-5'-phosphate decarboxylase activity
J7S26_RS04045	COG0194	GDP metabolic process
J7S26_RS04055	COG0301	tRNA thio-modification
J7S26_RS04090	COG0635	Involved in the biosynthesis of porphyrin-containing compound
J7S26_RS04095	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
J7S26_RS04105	COG0481	GTPase activity
J7S26_RS04110	COG0268	Binds directly to 16S ribosomal RNA
J7S26_RS04140	COG1420	regulation of RNA biosynthetic process
J7S26_RS04145	COG0484	heat shock protein binding
J7S26_RS04155	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
J7S26_RS04165	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
J7S26_RS04180	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
J7S26_RS04185	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
J7S26_RS04195	COG0116	Belongs to the methyltransferase superfamily
J7S26_RS04195	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
J7S26_RS04205	COG3853	Toxic anion resistance protein (TelA)
J7S26_RS04235	COG0861	Integral membrane protein TerC family
J7S26_RS04240	COG1418	mRNA catabolic process
J7S26_RS04250	COG2359	stage V sporulation protein S
J7S26_RS04255	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
J7S26_RS04260	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
J7S26_RS04270	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
J7S26_RS04275	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
J7S26_RS04280	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
J7S26_RS04285	COG0756	dUTP diphosphatase activity
J7S26_RS04305	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
J7S26_RS04305	COG3976	FMN-binding domain protein
J7S26_RS04315	COG0437	4 iron, 4 sulfur cluster binding
J7S26_RS04320	COG0243	molybdopterin cofactor binding
J7S26_RS04330	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
J7S26_RS04360	COG1686	Belongs to the peptidase S11 family
J7S26_RS04365	COG2720	vancomycin resistance protein
J7S26_RS04380	COG0649	NAD binding
J7S26_RS04390	COG3260	NADH ubiquinone oxidoreductase 20
J7S26_RS04400	COG2111	Na H antiporter
J7S26_RS04400	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
J7S26_RS04410	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
J7S26_RS04415	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
J7S26_RS04420	COG0564	pseudouridine synthase activity
J7S26_RS04425	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
J7S26_RS04430	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
J7S26_RS04450	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
J7S26_RS04455	COG1937	Protein conserved in bacteria
J7S26_RS04460	COG2217	Heavy metal translocating P-type atpase
J7S26_RS04475	COG1136	(ABC) transporter
J7S26_RS04475	COG0577	efflux transmembrane transporter activity
J7S26_RS04485	COG0745	RESPONSE REGULATOR receiver
J7S26_RS04490	COG0538	isocitrate dehydrogenase activity
J7S26_RS04505	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
J7S26_RS04505	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
J7S26_RS04510	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
J7S26_RS04515	COG0242	peptide deformylase activity
J7S26_RS04535	COG0232	Belongs to the dGTPase family. Type 2 subfamily
J7S26_RS04550	COG0280	phosphate acetyltransferase
J7S26_RS04575	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
J7S26_RS04580	COG1114	Component of the transport system for branched-chain amino acids
J7S26_RS04605	COG0574	Belongs to the PEP-utilizing enzyme family
J7S26_RS04605	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
J7S26_RS04610	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
J7S26_RS04615	COG0751	glycine-tRNA ligase activity
J7S26_RS04620	COG0752	glycyl-tRNA synthetase alpha subunit
J7S26_RS04625	COG0681	Belongs to the peptidase S26 family
J7S26_RS04630	COG0336	Belongs to the RNA methyltransferase TrmD family
J7S26_RS04645	COG0228	four-way junction DNA binding
J7S26_RS04650	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
J7S26_RS04655	COG4988	ABC transporter
J7S26_RS04665	COG0812	UDP-N-acetylmuramate dehydrogenase activity
J7S26_RS04675	COG2814	Major facilitator Superfamily
J7S26_RS04695	COG0562	UDP-galactopyranose mutase
J7S26_RS04700	COG1216	Glycosyl transferase, family 2
J7S26_RS04705	COG1216	Glycosyl transferase, family 2
J7S26_RS04710	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
J7S26_RS04720	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
J7S26_RS04725	COG1216	Glycosyl transferase, family 2
J7S26_RS04745	COG3475	LICD family
J7S26_RS04775	COG0617	tRNA 3'-terminal CCA addition
J7S26_RS04790	COG1611	Belongs to the LOG family
J7S26_RS04795	COG1228	amidohydrolase
J7S26_RS04800	COG2827	Endonuclease containing a URI domain
J7S26_RS04825	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
J7S26_RS04835	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
J7S26_RS04850	COG1691	(AIR) carboxylase
J7S26_RS04870	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
J7S26_RS04875	COG4750	Nucleotidyl transferase
J7S26_RS04880	COG0697	spore germination
J7S26_RS04890	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
J7S26_RS04915	COG1131	(ABC) transporter
J7S26_RS04990	COG0018	arginyl-trna synthetase
J7S26_RS05000	COG1288	antiporter activity
J7S26_RS05005	COG0549	Belongs to the carbamate kinase family
J7S26_RS05010	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
J7S26_RS05015	COG2235	arginine
J7S26_RS05030	COG0437	4 iron, 4 sulfur cluster binding
J7S26_RS05035	COG0243	molybdopterin cofactor binding
J7S26_RS05075	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
J7S26_RS05080	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
J7S26_RS05085	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
J7S26_RS05110	COG1363	Peptidase, m42
J7S26_RS05125	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
J7S26_RS05135	COG1028	Short-chain dehydrogenase reductase Sdr
J7S26_RS05140	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
J7S26_RS05165	COG0557	exoribonuclease II activity
J7S26_RS05170	COG0793	Belongs to the peptidase S41A family
J7S26_RS05175	COG2177	Part of the ABC transporter FtsEX involved in
J7S26_RS05180	COG2884	Cell division ATP-binding protein ftsE
J7S26_RS05185	COG3958	Transketolase
J7S26_RS05190	COG3959	Transketolase, thiamine diphosphate binding domain
J7S26_RS05195	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
J7S26_RS05200	COG0653	protein targeting
J7S26_RS05205	COG3629	intracellular signal transduction
J7S26_RS05210	COG2890	protein-(glutamine-N5) methyltransferase activity
J7S26_RS05220	COG0492	ferredoxin-NADP+ reductase activity
J7S26_RS05235	COG0569	domain protein
J7S26_RS05235	COG0475	glutathione-regulated potassium exporter activity
J7S26_RS05240	COG4145	pantothenate transmembrane transporter activity
J7S26_RS05250	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
J7S26_RS05260	COG0799	negative regulation of ribosome biogenesis
J7S26_RS05270	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
J7S26_RS05275	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
J7S26_RS05280	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
J7S26_RS05285	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
J7S26_RS05290	COG0211	Belongs to the bacterial ribosomal protein bL27 family
J7S26_RS05295	COG0261	This protein binds to 23S rRNA in the presence of protein L20
J7S26_RS05305	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
J7S26_RS05310	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
J7S26_RS05315	COG0602	queuosine metabolic process
J7S26_RS05320	COG0720	synthase
J7S26_RS05330	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
J7S26_RS05335	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
J7S26_RS05350	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
J7S26_RS05355	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
J7S26_RS05360	COG0745	RESPONSE REGULATOR receiver
J7S26_RS05365	COG0174	glutamine synthetase
J7S26_RS05380	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
J7S26_RS05385	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
J7S26_RS05395	COG0463	Glycosyl transferase, family 2
J7S26_RS05400	COG0443	Heat shock 70 kDa protein
J7S26_RS05405	COG0484	heat shock protein binding
J7S26_RS05425	COG0460	homoserine dehydrogenase
J7S26_RS05445	COG1362	aminopeptidase activity
J7S26_RS05455	COG1592	Rubrerythrin
J7S26_RS05470	COG1131	(ABC) transporter
J7S26_RS05490	COG2197	response regulator
J7S26_RS05535	COG1307	EDD domain protein, DegV family
J7S26_RS05545	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
J7S26_RS05550	COG1774	PSP1 C-terminal conserved region
J7S26_RS05560	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
J7S26_RS05570	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
J7S26_RS05585	COG0551	DNA topoisomerase type I activity
J7S26_RS05585	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
J7S26_RS05590	COG0367	asparagine synthase
J7S26_RS05605	COG0081	regulation of translation
J7S26_RS05610	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
J7S26_RS05615	COG0250	Participates in transcription elongation, termination and antitermination
J7S26_RS05630	COG0267	Belongs to the bacterial ribosomal protein bL33 family
J7S26_RS05655	COG0791	NLP P60 protein
J7S26_RS05660	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
J7S26_RS05665	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
J7S26_RS05675	COG1013	pyruvate-flavodoxin oxidoreductase activity
J7S26_RS05675	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
J7S26_RS05675	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
J7S26_RS05675	COG0674	pyruvate-flavodoxin oxidoreductase activity
J7S26_RS05705	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
J7S26_RS05710	COG4608	Belongs to the ABC transporter superfamily
J7S26_RS05725	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
J7S26_RS05730	COG0363	glucosamine-6-phosphate deaminase activity
J7S26_RS05740	COG0563	adenylate kinase activity
J7S26_RS05745	COG0201	protein transport
J7S26_RS05750	COG0200	Binds to the 23S rRNA
J7S26_RS05755	COG1841	ribosomal large subunit assembly
J7S26_RS05760	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
J7S26_RS05765	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
J7S26_RS05770	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
J7S26_RS05775	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
J7S26_RS05780	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
J7S26_RS05785	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
J7S26_RS05790	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
J7S26_RS05795	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
J7S26_RS05800	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
J7S26_RS05805	COG0255	Belongs to the universal ribosomal protein uL29 family
J7S26_RS05810	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
J7S26_RS05815	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
J7S26_RS05825	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
J7S26_RS05830	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
J7S26_RS05835	COG0006	proline dipeptidase activity
J7S26_RS05850	COG0544	peptidyl-prolyl cis-trans isomerase activity
J7S26_RS05860	COG1136	(ABC) transporter
J7S26_RS05865	COG0089	rRNA binding
J7S26_RS05870	COG0088	Forms part of the polypeptide exit tunnel
J7S26_RS05875	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
J7S26_RS05880	COG0051	transcription antitermination factor activity, RNA binding
J7S26_RS05885	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
J7S26_RS05895	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
J7S26_RS05980	COG0348	domain, Protein
J7S26_RS05995	COG0243	molybdopterin cofactor binding
J7S26_RS06000	COG0437	4 iron, 4 sulfur cluster binding
J7S26_RS06005	COG2195	Cleaves the N-terminal amino acid of tripeptides
J7S26_RS06010	COG0517	IMP dehydrogenase activity
J7S26_RS06010	COG1227	inorganic diphosphatase activity
J7S26_RS06015	COG1760	l-serine dehydratase
J7S26_RS06025	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
J7S26_RS06035	COG0537	adenosine 5'-monophosphoramidase activity
J7S26_RS06040	COG1028	Short-chain dehydrogenase reductase Sdr
J7S26_RS06045	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
J7S26_RS06050	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
J7S26_RS06060	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
J7S26_RS06065	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
J7S26_RS06090	COG2949	membrane
J7S26_RS06130	COG1013	pyruvate-flavodoxin oxidoreductase activity
J7S26_RS06135	COG0674	pyruvate-flavodoxin oxidoreductase activity
J7S26_RS06140	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
J7S26_RS06145	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
J7S26_RS06170	COG0516	GMP reductase activity
J7S26_RS06170	COG0517	IMP dehydrogenase activity
J7S26_RS06185	COG0745	RESPONSE REGULATOR receiver
J7S26_RS06215	COG0393	Putative heavy-metal-binding
J7S26_RS06220	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
J7S26_RS06225	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
J7S26_RS06250	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
J7S26_RS06255	COG0438	transferase activity, transferring glycosyl groups
J7S26_RS06270	COG1309	transcriptional regulator
J7S26_RS06300	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
J7S26_RS06305	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
J7S26_RS06310	COG2270	Major facilitator Superfamily
J7S26_RS06330	COG2860	membrane
J7S26_RS06335	COG1392	Phosphate transport regulator
J7S26_RS06340	COG0306	phosphate transporter
J7S26_RS06345	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
J7S26_RS06350	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
J7S26_RS06355	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
J7S26_RS06355	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
J7S26_RS06360	COG0205	6-phosphofructokinase activity
J7S26_RS06365	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
J7S26_RS06375	COG0569	domain protein
J7S26_RS06385	COG1253	flavin adenine dinucleotide binding
J7S26_RS06390	COG1272	protein, Hemolysin III
J7S26_RS06395	COG3428	Bacterial PH domain
J7S26_RS06415	COG1610	YqeY-like protein
J7S26_RS06420	COG1210	Utp--glucose-1-phosphate uridylyltransferase
J7S26_RS06435	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
J7S26_RS06440	COG1131	(ABC) transporter
J7S26_RS06445	COG1138	Cytochrome C-type biogenesis protein
J7S26_RS06450	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
J7S26_RS06455	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
J7S26_RS06470	COG5002	protein histidine kinase activity
J7S26_RS06470	COG2205	protein histidine kinase activity
J7S26_RS06470	COG0784	Response regulator, receiver
J7S26_RS06475	COG2223	nitrite transmembrane transporter activity
J7S26_RS06490	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
J7S26_RS06505	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
J7S26_RS06515	COG0084	hydrolase, TatD family'
J7S26_RS06520	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
J7S26_RS06520	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
J7S26_RS06535	COG0019	diaminopimelate decarboxylase activity
J7S26_RS06560	COG1045	serine acetyltransferase
J7S26_RS06600	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
J7S26_RS06615	COG5002	protein histidine kinase activity
J7S26_RS06620	COG0745	RESPONSE REGULATOR receiver
J7S26_RS06630	COG1268	BioY protein
J7S26_RS06655	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
J7S26_RS06660	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
J7S26_RS06665	COG0424	maF-like protein
J7S26_RS06680	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
J7S26_RS06690	COG1950	PFAM Membrane protein of
J7S26_RS06695	COG0488	(ABC) transporter
J7S26_RS06705	COG1122	ATPase activity
J7S26_RS06710	COG1122	ATPase activity
J7S26_RS06715	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
J7S26_RS06720	COG2814	Major facilitator Superfamily
J7S26_RS06725	COG0193	aminoacyl-tRNA hydrolase activity
J7S26_RS06730	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
J7S26_RS06735	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
J7S26_RS06740	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
J7S26_RS06755	COG0285	dihydrofolate synthase activity
J7S26_RS06765	COG3620	sequence-specific DNA binding
J7S26_RS06770	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
J7S26_RS06775	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
J7S26_RS06780	COG0598	Magnesium transport protein CorA
J7S26_RS06785	COG1573	uracil-dna glycosylase
J7S26_RS06790	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
J7S26_RS06800	COG0789	Transcriptional regulator
J7S26_RS06815	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
J7S26_RS06840	COG1464	Belongs to the NlpA lipoprotein family
J7S26_RS06845	COG2011	ABC-type metal ion transport system permease component
J7S26_RS06850	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
J7S26_RS06860	COG0546	phosphoglycolate phosphatase activity
J7S26_RS06870	COG3275	phosphorelay sensor kinase activity
J7S26_RS06875	COG0730	response to heat
J7S26_RS06885	COG2197	response regulator
J7S26_RS06890	COG2235	arginine
J7S26_RS06900	COG0477	Major facilitator Superfamily
J7S26_RS06915	COG1834	amidinotransferase
J7S26_RS06920	COG0298	carbon dioxide binding
J7S26_RS06930	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
J7S26_RS06935	COG3279	Response regulator of the LytR AlgR family
J7S26_RS06945	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
J7S26_RS06980	COG0459	protein refolding
J7S26_RS06985	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
J7S26_RS07000	COG1120	ATPase activity
J7S26_RS07005	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
J7S26_RS07020	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
J7S26_RS07050	COG0203	ribosomal protein L17
J7S26_RS07055	COG0202	RNA polymerase activity
J7S26_RS07060	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
J7S26_RS07065	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
J7S26_RS07070	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
J7S26_RS07080	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
J7S26_RS07085	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
J7S26_RS07085	COG1918	ferrous iron import across plasma membrane
J7S26_RS07090	COG3279	Response regulator of the LytR AlgR family
J7S26_RS07095	COG0745	RESPONSE REGULATOR receiver
J7S26_RS07095	COG2972	Histidine kinase
J7S26_RS07120	COG0251	oxidation-reduction process
J7S26_RS07140	COG2814	Major facilitator Superfamily
J7S26_RS07145	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
J7S26_RS07155	COG0514	ATP-dependent DNA helicase (RecQ)
J7S26_RS07190	COG0347	Belongs to the P(II) protein family
J7S26_RS07195	COG0004	ammonium transporteR
J7S26_RS07205	COG0519	Catalyzes the synthesis of GMP from XMP
J7S26_RS07210	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
J7S26_RS07225	COG1979	alcohol dehydrogenase
J7S26_RS07230	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
J7S26_RS07235	COG2897	thiosulfate sulfurtransferase activity
J7S26_RS07245	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
J7S26_RS07270	COG0166	Belongs to the GPI family
J7S26_RS07280	COG0058	SHG alpha-glucan phosphorylase activity
J7S26_RS07285	COG0297	glycogen (starch) synthase activity
J7S26_RS07290	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
J7S26_RS07295	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
J7S26_RS07305	COG0697	spore germination
J7S26_RS07315	COG0736	holo-[acyl-carrier-protein] synthase activity
J7S26_RS07330	COG0280	phosphate acetyltransferase
J7S26_RS07335	COG3426	butyrate kinase activity
J7S26_RS07355	COG0513	Belongs to the DEAD box helicase family
J7S26_RS07380	COG0583	DNA-binding transcription factor activity
J7S26_RS07385	COG3381	protein complex oligomerization
J7S26_RS07390	COG0437	4 iron, 4 sulfur cluster binding
J7S26_RS07395	COG0243	molybdopterin cofactor binding
J7S26_RS07400	COG0546	phosphoglycolate phosphatase activity
J7S26_RS07405	COG0442	prolyl-tRNA aminoacylation
J7S26_RS07410	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
J7S26_RS07415	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
J7S26_RS07420	COG0750	zinc metalloprotease
J7S26_RS07425	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
J7S26_RS07430	COG0575	Belongs to the CDS family
J7S26_RS07435	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
J7S26_RS07450	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
J7S26_RS07450	COG1215	transferase activity, transferring glycosyl groups
J7S26_RS07460	COG1442	glycosyl transferase family 8
J7S26_RS07460	COG1216	Glycosyl transferase, family 2
J7S26_RS07475	COG0233	cytoplasmic translational termination
J7S26_RS07480	COG0528	UMP kinase activity
J7S26_RS07490	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
J7S26_RS07515	COG0544	peptidyl-prolyl cis-trans isomerase activity
J7S26_RS07520	COG1047	Peptidyl-prolyl cis-trans
J7S26_RS07555	COG2814	Major facilitator Superfamily
J7S26_RS07565	COG2197	response regulator
J7S26_RS07590	COG2815	serine threonine protein kinase
J7S26_RS07590	COG0515	serine threonine protein kinase
J7S26_RS07595	COG0745	RESPONSE REGULATOR receiver
J7S26_RS07625	COG1136	(ABC) transporter
J7S26_RS07625	COG0577	efflux transmembrane transporter activity
J7S26_RS07640	COG1490	D-aminoacyl-tRNA deacylase activity
J7S26_RS07645	COG1116	anion transmembrane transporter activity
J7S26_RS07655	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
J7S26_RS07665	COG1811	Na channel or pump
J7S26_RS07685	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
J7S26_RS07690	COG0521	Mo-molybdopterin cofactor biosynthetic process
J7S26_RS07730	COG2197	response regulator
J7S26_RS07750	COG0367	asparagine synthase
J7S26_RS07755	COG2239	Acts as a magnesium transporter
J7S26_RS07780	COG1959	2 iron, 2 sulfur cluster binding
J7S26_RS07785	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
J7S26_RS07800	COG1757	Na H antiporter
J7S26_RS07810	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
J7S26_RS07825	COG0674	pyruvate-flavodoxin oxidoreductase activity
J7S26_RS07865	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
J7S26_RS07885	COG1484	DNA-dependent DNA replication
J7S26_RS07905	COG3328	transposase activity
J7S26_RS07930	COG0657	acetylesterase activity
J7S26_RS07955	COG1834	amidinotransferase
J7S26_RS07965	COG0386	Belongs to the glutathione peroxidase family
J7S26_RS08015	COG0733	neurotransmitter:sodium symporter activity
J7S26_RS08025	COG0733	neurotransmitter:sodium symporter activity
J7S26_RS08030	COG1376	ErfK ybiS ycfS ynhG family protein
J7S26_RS08055	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
J7S26_RS08055	COG0646	methionine synthase
J7S26_RS08070	COG2226	methyltransferase
J7S26_RS08075	COG0635	Involved in the biosynthesis of porphyrin-containing compound
J7S26_RS08080	COG0402	S-adenosylhomocysteine deaminase activity
J7S26_RS08095	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
J7S26_RS08110	COG0398	Pfam SNARE associated Golgi protein
J7S26_RS08125	COG1842	Phage shock protein A
J7S26_RS08135	COG2814	Major facilitator Superfamily
J7S26_RS08140	COG3976	FMN-binding domain protein
J7S26_RS08140	COG1053	succinate dehydrogenase
J7S26_RS08140	COG0431	NADPH-dependent FMN reductase
J7S26_RS08145	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
J7S26_RS08145	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
J7S26_RS08150	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
J7S26_RS08160	COG1181	Belongs to the D-alanine--D-alanine ligase family
J7S26_RS08165	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
J7S26_RS08280	COG1459	type II secretion system
J7S26_RS08385	COG0459	protein refolding
J7S26_RS08405	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
J7S26_RS08410	COG0802	atpase or kinase
J7S26_RS08415	COG1373	ATPase (AAA superfamily
J7S26_RS08420	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
J7S26_RS08425	COG0635	Involved in the biosynthesis of porphyrin-containing compound
J7S26_RS08435	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
J7S26_RS08445	COG0420	3'-5' exonuclease activity
J7S26_RS08450	COG0305	Participates in initiation and elongation during chromosome replication
J7S26_RS08455	COG0359	binds to the 23S rRNA
J7S26_RS08460	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
J7S26_RS08465	COG0629	single-stranded DNA binding
J7S26_RS08470	COG0360	Binds together with S18 to 16S ribosomal RNA
J7S26_RS08480	COG1119	ATPase activity
J7S26_RS08500	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
J7S26_RS08505	COG1217	gtp-binding protein TYPA
J7S26_RS08510	COG0484	heat shock protein binding
J7S26_RS08515	COG2223	nitrite transmembrane transporter activity
J7S26_RS08535	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
J7S26_RS08540	COG0187	DNA topoisomerase II activity
J7S26_RS08545	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
J7S26_RS08550	COG0592	DNA-directed DNA polymerase activity