locus-tag	class	description
ET495_RS00010	COG4152	abc transporter atp-binding protein
ET495_RS00015	COG1309	transcriptional regulator
ET495_RS00025	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ET495_RS00040	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
ET495_RS00045	COG0193	aminoacyl-tRNA hydrolase activity
ET495_RS00065	COG0438	transferase activity, transferring glycosyl groups
ET495_RS00075	COG0438	transferase activity, transferring glycosyl groups
ET495_RS00140	COG1136	(ABC) transporter
ET495_RS00150	COG0148	phosphopyruvate hydratase activity
ET495_RS00185	COG4608	Belongs to the ABC transporter superfamily
ET495_RS00220	COG1252	NADH dehydrogenase
ET495_RS00235	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ET495_RS00270	COG1312	Catalyzes the dehydration of D-mannonate
ET495_RS00275	COG0246	Mannitol dehydrogenase
ET495_RS00290	COG1904	glucuronate isomerase
ET495_RS00295	COG2813	Specifically methylates the guanine in position
ET495_RS00315	COG2226	methyltransferase
ET495_RS00320	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ET495_RS00335	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ET495_RS00340	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ET495_RS00350	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ET495_RS00355	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ET495_RS00365	COG1570	exodeoxyribonuclease VII activity
ET495_RS00370	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ET495_RS00375	COG1322	Protein conserved in bacteria
ET495_RS00395	COG0012	GTP binding
ET495_RS00415	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ET495_RS00445	COG4172	Belongs to the ABC transporter superfamily
ET495_RS00450	COG1217	gtp-binding protein TYPA
ET495_RS00455	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ET495_RS00475	COG0077	Prephenate dehydratase
ET495_RS00480	COG0287	Prephenate dehydrogenase
ET495_RS00520	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ET495_RS00540	COG4122	O-methyltransferase activity
ET495_RS00560	COG0180	Tryptophanyl-tRNA synthetase
ET495_RS00585	COG3328	transposase activity
ET495_RS00605	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ET495_RS00610	COG1053	succinate dehydrogenase
ET495_RS00620	COG2009	succinate dehydrogenase
ET495_RS00625	COG0662	Cupin 2, conserved barrel domain protein
ET495_RS00625	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
ET495_RS00635	COG1744	ABC transporter substrate-binding protein PnrA-like
ET495_RS00645	COG4603	Belongs to the binding-protein-dependent transport system permease family
ET495_RS00650	COG1079	Belongs to the binding-protein-dependent transport system permease family
ET495_RS00675	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
ET495_RS00715	COG0672	)-iron permease
ET495_RS00735	COG4770	biotin carboxylase activity
ET495_RS00740	COG0424	maF-like protein
ET495_RS00745	COG0679	Auxin Efflux Carrier
ET495_RS00765	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ET495_RS00785	COG1316	TRANSCRIPTIONal
ET495_RS00825	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
ET495_RS00835	COG2177	Part of the ABC transporter FtsEX involved in
ET495_RS00845	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ET495_RS00860	COG1846	Transcriptional regulator
ET495_RS00860	COG1940	carbohydrate kinase activity
ET495_RS00870	COG1175	transmembrane transport
ET495_RS00885	COG0363	glucosamine-6-phosphate deaminase activity
ET495_RS00910	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ET495_RS00915	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
ET495_RS00925	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
ET495_RS00945	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
ET495_RS00950	COG0488	(ABC) transporter
ET495_RS00960	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ET495_RS00965	COG1175	transmembrane transport
ET495_RS00985	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ET495_RS01005	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ET495_RS01040	COG0009	L-threonylcarbamoyladenylate synthase
ET495_RS01050	COG0318	PFAM AMP-dependent synthetase and ligase
ET495_RS01055	COG1181	Belongs to the D-alanine--D-alanine ligase family
ET495_RS01075	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ET495_RS01080	COG1461	Dihydroxyacetone kinase
ET495_RS01090	COG0742	ribosomal rna small subunit methyltransferase
ET495_RS01095	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
ET495_RS01110	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ET495_RS01115	COG0571	ribonuclease III activity
ET495_RS01120	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ET495_RS01130	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
ET495_RS01135	COG4988	ABC transporter
ET495_RS01140	COG1294	oxidase, subunit
ET495_RS01145	COG1271	oxidase subunit
ET495_RS01155	COG1530	ribonuclease E activity
ET495_RS01160	COG1435	thymidine kinase activity
ET495_RS01170	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ET495_RS01175	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ET495_RS01180	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ET495_RS01190	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
ET495_RS01200	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ET495_RS01205	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ET495_RS01215	COG0799	negative regulation of ribosome biogenesis
ET495_RS01220	COG0406	alpha-ribazole phosphatase activity
ET495_RS01250	COG1028	Short-chain dehydrogenase reductase Sdr
ET495_RS01255	COG0183	Belongs to the thiolase family
ET495_RS01260	COG1024	Enoyl-CoA hydratase
ET495_RS01285	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
ET495_RS01320	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ET495_RS01335	COG1012	belongs to the aldehyde dehydrogenase family
ET495_RS01340	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ET495_RS01345	COG0583	DNA-binding transcription factor activity
ET495_RS01355	COG0765	amino acid transport
ET495_RS01360	COG4598	ABC transporter
ET495_RS01365	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
ET495_RS01370	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ET495_RS01375	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
ET495_RS01400	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
ET495_RS01420	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ET495_RS01440	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
ET495_RS01465	COG0714	Associated with various cellular activities
ET495_RS01530	COG1404	Belongs to the peptidase S8 family
ET495_RS01545	COG1404	Belongs to the peptidase S8 family
ET495_RS01550	COG1404	Belongs to the peptidase S8 family
ET495_RS01555	COG1404	Belongs to the peptidase S8 family
ET495_RS01600	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
ET495_RS01625	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
ET495_RS01645	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ET495_RS01650	COG0668	transmembrane transport
ET495_RS01715	COG1045	serine acetyltransferase
ET495_RS01725	COG0371	Dehydrogenase
ET495_RS01750	COG4569	acetaldehyde dehydrogenase (acetylating) activity
ET495_RS01815	COG1414	Transcriptional regulator
ET495_RS01825	COG1132	(ABC) transporter
ET495_RS01830	COG0544	peptidyl-prolyl cis-trans isomerase activity
ET495_RS01840	COG0740	serine-type endopeptidase activity
ET495_RS01845	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ET495_RS01850	COG1022	Amp-dependent synthetase and ligase
ET495_RS01855	COG1605	Chorismate mutase
ET495_RS01855	COG0287	Prephenate dehydrogenase
ET495_RS01870	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ET495_RS01875	COG0765	amino acid transport
ET495_RS01880	COG1126	abc transporter atp-binding protein
ET495_RS01890	COG0778	Nitroreductase
ET495_RS01890	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
ET495_RS01915	COG0395	ABC-type sugar transport system, permease component
ET495_RS01940	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ET495_RS01945	COG0285	dihydrofolate synthase activity
ET495_RS01950	COG2376	Dihydroxyacetone kinase
ET495_RS01970	COG0105	UTP biosynthetic process
ET495_RS02015	COG0228	four-way junction DNA binding
ET495_RS02020	COG1837	Belongs to the UPF0109 family
ET495_RS02025	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ET495_RS02030	COG0336	Belongs to the RNA methyltransferase TrmD family
ET495_RS02035	COG0335	large ribosomal subunit rRNA binding
ET495_RS02040	COG0681	Belongs to the peptidase S26 family
ET495_RS02045	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ET495_RS02055	COG0792	nuclease activity
ET495_RS02070	COG4974	Belongs to the 'phage' integrase family
ET495_RS02080	COG0052	Belongs to the universal ribosomal protein uS2 family
ET495_RS02085	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ET495_RS02095	COG0233	cytoplasmic translational termination
ET495_RS02125	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
ET495_RS02135	COG0352	thiamine-phosphate diphosphorylase activity
ET495_RS02140	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
ET495_RS02150	COG0750	zinc metalloprotease
ET495_RS02155	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
ET495_RS02170	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ET495_RS02175	COG0442	prolyl-tRNA aminoacylation
ET495_RS02185	COG0779	Required for maturation of 30S ribosomal subunits
ET495_RS02205	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ET495_RS02210	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
ET495_RS02225	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ET495_RS02225	COG0574	Belongs to the PEP-utilizing enzyme family
ET495_RS02230	COG0406	alpha-ribazole phosphatase activity
ET495_RS02235	COG0318	PFAM AMP-dependent synthetase and ligase
ET495_RS02280	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
ET495_RS02285	COG1185	polyribonucleotide nucleotidyltransferase activity
ET495_RS02290	COG0612	Peptidase, M16
ET495_RS02295	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
ET495_RS02315	COG0456	acetyltransferase
ET495_RS02365	COG1546	Belongs to the CinA family
ET495_RS02365	COG1058	Belongs to the CinA family
ET495_RS02370	COG1396	sequence-specific DNA binding
ET495_RS02395	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ET495_RS02395	COG1372	Participates in initiation and elongation during chromosome replication
ET495_RS02400	COG2137	regulation of response to DNA damage stimulus
ET495_RS02405	COG0765	amino acid transport
ET495_RS02410	COG0765	amino acid transport
ET495_RS02415	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ET495_RS02420	COG1126	abc transporter atp-binding protein
ET495_RS02425	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ET495_RS02455	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ET495_RS02460	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ET495_RS02465	COG2813	Specifically methylates the guanine in position
ET495_RS02485	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ET495_RS02500	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ET495_RS02505	COG1388	LysM domain
ET495_RS02510	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ET495_RS02515	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ET495_RS02530	COG1278	Cold shock
ET495_RS02545	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ET495_RS02565	COG0714	Associated with various cellular activities
ET495_RS02570	COG2001	Belongs to the MraZ family
ET495_RS02575	COG0275	rRNA processing
ET495_RS02585	COG0768	penicillin binding
ET495_RS02600	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ET495_RS02605	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ET495_RS02615	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ET495_RS02620	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ET495_RS02630	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ET495_RS02640	COG1799	cell septum assembly
ET495_RS02650	COG3599	regulation of cell shape
ET495_RS02660	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ET495_RS02675	COG0587	DNA-directed DNA polymerase activity
ET495_RS02690	COG2501	S4 domain
ET495_RS02695	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ET495_RS02705	COG1073	alpha beta
ET495_RS02725	COG0131	Imidazoleglycerol-phosphate dehydratase
ET495_RS02735	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ET495_RS02765	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
ET495_RS02770	COG0291	Belongs to the bacterial ribosomal protein bL35 family
ET495_RS02775	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ET495_RS02780	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ET495_RS02790	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ET495_RS02815	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ET495_RS02820	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
ET495_RS02825	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ET495_RS02830	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ET495_RS02840	COG1438	arginine binding
ET495_RS02845	COG0165	Argininosuccinate lyase
ET495_RS02855	COG2094	Belongs to the DNA glycosylase MPG family
ET495_RS02910	COG0497	DNA recombination
ET495_RS02935	COG0504	CTP synthase activity
ET495_RS02985	COG0719	Fe-S assembly protein
ET495_RS02995	COG0396	ATPase activity
ET495_RS03005	COG0822	iron-sulfur transferase activity
ET495_RS03010	COG2151	metal-sulfur cluster biosynthetic enzyme
ET495_RS03035	COG2337	Toxic component of a toxin-antitoxin (TA) module
ET495_RS03040	COG1120	ATPase activity
ET495_RS03080	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ET495_RS03090	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ET495_RS03095	COG0254	rRNA binding
ET495_RS03100	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ET495_RS03120	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ET495_RS03135	COG2855	membrane
ET495_RS03145	COG1695	Transcriptional regulator
ET495_RS03165	COG0488	(ABC) transporter
ET495_RS03225	COG1119	ATPase activity
ET495_RS03285	COG1881	PFAM PEBP family protein
ET495_RS03360	COG3328	transposase activity
ET495_RS03380	COG0582	viral genome integration into host DNA
ET495_RS03410	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
ET495_RS03425	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ET495_RS03435	COG3328	transposase activity
ET495_RS03460	COG3328	transposase activity
ET495_RS03520	COG0488	(ABC) transporter
ET495_RS03525	COG1335	isochorismatase
ET495_RS03530	COG2514	catechol 2,3-dioxygenase activity
ET495_RS03545	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ET495_RS03560	COG0667	Aldo Keto reductase
ET495_RS03570	COG0215	cysteine-tRNA ligase activity
ET495_RS03590	COG1994	Peptidase M50
ET495_RS03590	COG0517	IMP dehydrogenase activity
ET495_RS03600	COG1222	aaa ATPase
ET495_RS03605	COG4122	O-methyltransferase activity
ET495_RS03615	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
ET495_RS03625	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
ET495_RS03640	COG1132	(ABC) transporter
ET495_RS03645	COG1132	(ABC) transporter
ET495_RS03670	COG0134	indole-3-glycerol-phosphate synthase activity
ET495_RS03675	COG0133	tryptophan synthase activity
ET495_RS03680	COG0159	tryptophan synthase activity
ET495_RS03685	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ET495_RS03690	COG0070	glutamate synthase
ET495_RS03690	COG0069	glutamate synthase activity
ET495_RS03690	COG0067	glutamate synthase
ET495_RS03745	COG2226	methyltransferase
ET495_RS03755	COG0539	negative regulation of cytoplasmic translation
ET495_RS03780	COG0237	dephospho-CoA kinase activity
ET495_RS03805	COG0556	nucleotide-excision repair
ET495_RS03830	COG2267	carboxylic ester hydrolase activity
ET495_RS03840	COG3842	ATPase activity
ET495_RS03870	COG1660	Displays ATPase and GTPase activities
ET495_RS03875	COG0391	Required for morphogenesis under gluconeogenic growth conditions
ET495_RS03880	COG1022	Amp-dependent synthetase and ligase
ET495_RS03890	COG1481	regulation of sporulation
ET495_RS03895	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ET495_RS03900	COG0126	phosphoglycerate kinase activity
ET495_RS03910	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ET495_RS03920	COG0363	glucosamine-6-phosphate deaminase activity
ET495_RS03935	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ET495_RS03945	COG0109	protoheme IX farnesyltransferase activity
ET495_RS03960	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
ET495_RS03965	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
ET495_RS03985	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ET495_RS04015	COG3328	transposase activity
ET495_RS04030	COG3328	transposase activity
ET495_RS04065	COG0583	DNA-binding transcription factor activity
ET495_RS04100	COG1131	(ABC) transporter
ET495_RS04110	COG1131	(ABC) transporter
ET495_RS04180	COG1028	Short-chain dehydrogenase reductase Sdr
ET495_RS04190	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ET495_RS04195	COG1960	acyl-CoA dehydrogenase activity
ET495_RS04205	COG1028	Short-chain dehydrogenase reductase Sdr
ET495_RS04225	COG0477	Major facilitator Superfamily
ET495_RS04240	COG2235	arginine
ET495_RS04245	COG0183	Belongs to the thiolase family
ET495_RS04260	COG3284	Transcriptional regulator
ET495_RS04265	COG0145	ligase activity
ET495_RS04270	COG4647	ligase activity
ET495_RS04275	COG0145	ligase activity
ET495_RS04320	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ET495_RS04325	COG1136	(ABC) transporter
ET495_RS04325	COG0577	efflux transmembrane transporter activity
ET495_RS04335	COG1028	Short-chain dehydrogenase reductase Sdr
ET495_RS04340	COG1349	DNA-binding transcription factor activity
ET495_RS04370	COG2239	Acts as a magnesium transporter
ET495_RS04375	COG1846	Transcriptional regulator
ET495_RS04400	COG0765	amino acid transport
ET495_RS04405	COG0765	amino acid transport
ET495_RS04425	COG3548	integral membrane protein
ET495_RS04435	COG0651	ATP synthesis coupled electron transport
ET495_RS04460	COG0713	ATP synthesis coupled electron transport
ET495_RS04470	COG0475	glutathione-regulated potassium exporter activity
ET495_RS04515	COG1254	Belongs to the acylphosphatase family
ET495_RS04530	COG1132	(ABC) transporter
ET495_RS04535	COG1132	(ABC) transporter
ET495_RS04545	COG0583	DNA-binding transcription factor activity
ET495_RS04550	COG0009	L-threonylcarbamoyladenylate synthase
ET495_RS04565	COG1739	Uncharacterized protein family UPF0029
ET495_RS04575	COG0456	acetyltransferase
ET495_RS04580	COG0783	Belongs to the Dps family
ET495_RS04595	COG0714	Associated with various cellular activities
ET495_RS04615	COG2378	regulation of single-species biofilm formation
ET495_RS04630	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ET495_RS04635	COG0805	protein transport
ET495_RS04655	COG1228	amidohydrolase
ET495_RS04665	COG1216	Glycosyl transferase, family 2
ET495_RS04705	COG0137	argininosuccinate synthase activity
ET495_RS04735	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
ET495_RS04770	COG1716	ATPase activity
ET495_RS04805	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
ET495_RS04810	COG0140	phosphoribosyl-ATP diphosphatase activity
ET495_RS04815	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ET495_RS04820	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ET495_RS04820	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ET495_RS04835	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ET495_RS04845	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ET495_RS04850	COG1011	Hydrolase
ET495_RS04860	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ET495_RS04870	COG1758	RNA polymerase activity
ET495_RS04875	COG0194	GDP metabolic process
ET495_RS04880	COG0322	excinuclease ABC activity
ET495_RS04890	COG0284	orotidine-5'-phosphate decarboxylase activity
ET495_RS04895	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ET495_RS04910	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ET495_RS04915	COG0540	Belongs to the ATCase OTCase family
ET495_RS04920	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
ET495_RS04925	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ET495_RS04930	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ET495_RS04945	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ET495_RS04950	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
ET495_RS04985	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ET495_RS04990	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
ET495_RS04995	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ET495_RS05000	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ET495_RS05005	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ET495_RS05010	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ET495_RS05030	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ET495_RS05040	COG1609	Transcriptional regulator
ET495_RS05060	COG1222	aaa ATPase
ET495_RS05070	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ET495_RS05080	COG0124	histidyl-tRNA synthetase
ET495_RS05115	COG1196	nuclear chromosome segregation
ET495_RS05130	COG1793	dna ligase
ET495_RS05140	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ET495_RS05145	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ET495_RS05150	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ET495_RS05160	COG2255	four-way junction helicase activity
ET495_RS05165	COG0632	four-way junction helicase activity
ET495_RS05170	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
ET495_RS05175	COG0217	transcriptional regulatory protein
ET495_RS05180	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
ET495_RS05185	COG1051	belongs to the nudix hydrolase family
ET495_RS05190	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
ET495_RS05205	COG1560	Kdo2-lipid A biosynthetic process
ET495_RS05210	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ET495_RS05220	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ET495_RS05250	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
ET495_RS05265	COG2814	Major facilitator Superfamily
ET495_RS05270	COG1309	transcriptional regulator
ET495_RS05280	COG0318	PFAM AMP-dependent synthetase and ligase
ET495_RS05295	COG3971	2-oxopent-4-enoate hydratase activity
ET495_RS05310	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ET495_RS05315	COG0477	Major facilitator Superfamily
ET495_RS05325	COG1012	belongs to the aldehyde dehydrogenase family
ET495_RS05330	COG1131	(ABC) transporter
ET495_RS05340	COG1131	(ABC) transporter
ET495_RS05380	COG0798	PFAM Bile acid sodium symporter
ET495_RS05385	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ET495_RS05395	COG3250	beta-galactosidase activity
ET495_RS05405	COG1175	transmembrane transport
ET495_RS05415	COG1609	Transcriptional regulator
ET495_RS05420	COG1846	Transcriptional regulator
ET495_RS05420	COG1940	carbohydrate kinase activity
ET495_RS05450	COG3596	GTP binding
ET495_RS05460	COG3547	Transposase (IS116 IS110 IS902 family)
ET495_RS05500	COG1136	(ABC) transporter
ET495_RS05500	COG0577	efflux transmembrane transporter activity
ET495_RS05520	COG2801	Transposase and inactivated derivatives
ET495_RS05530	COG1968	undecaprenyl-diphosphatase activity
ET495_RS05535	COG0390	transport system, permease component
ET495_RS05555	COG1397	ADP-ribosylglycohydrolase
ET495_RS05565	COG0395	ABC-type sugar transport system, permease component
ET495_RS05590	COG3547	Transposase (IS116 IS110 IS902 family)
ET495_RS05595	COG3547	Transposase (IS116 IS110 IS902 family)
ET495_RS05600	COG3547	Transposase (IS116 IS110 IS902 family)
ET495_RS05605	COG1028	Short-chain dehydrogenase reductase Sdr
ET495_RS05610	COG3328	transposase activity
ET495_RS05625	COG3328	transposase activity
ET495_RS05635	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ET495_RS05645	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ET495_RS05685	COG2326	polyphosphate kinase activity
ET495_RS05725	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
ET495_RS05740	COG0183	Belongs to the thiolase family
ET495_RS05750	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
ET495_RS05765	COG0516	GMP reductase activity
ET495_RS05765	COG0517	IMP dehydrogenase activity
ET495_RS05770	COG3973	AAA domain
ET495_RS05770	COG3973	AAA domain
ET495_RS05775	COG0494	nUDIX hydrolase
ET495_RS05795	COG1131	(ABC) transporter
ET495_RS05800	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ET495_RS05825	COG0531	amino acid
ET495_RS05830	COG0569	domain protein
ET495_RS05875	COG2860	membrane
ET495_RS05885	COG1435	thymidine kinase activity
ET495_RS05920	COG0596	Alpha beta hydrolase
ET495_RS05940	COG1918	ferrous iron import across plasma membrane
ET495_RS05940	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
ET495_RS05950	COG0646	methionine synthase
ET495_RS05950	COG1410	methionine synthase
ET495_RS05980	COG2337	Toxic component of a toxin-antitoxin (TA) module
ET495_RS06010	COG1396	sequence-specific DNA binding
ET495_RS06035	COG0559	Belongs to the binding-protein-dependent transport system permease family
ET495_RS06085	COG0738	Major facilitator superfamily
ET495_RS06090	COG2847	Copper chaperone PCu(A)C
ET495_RS06095	COG2837	iron assimilation
ET495_RS06125	COG3547	Transposase (IS116 IS110 IS902 family)
ET495_RS06215	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ET495_RS06220	COG0589	response to stress
ET495_RS06235	COG0142	geranyltranstransferase activity
ET495_RS06250	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
ET495_RS06270	COG1940	carbohydrate kinase activity
ET495_RS06290	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ET495_RS06300	COG1845	cytochrome c oxidase, subunit III
ET495_RS06305	COG2010	Cytochrome c
ET495_RS06310	COG0723	plastoquinol--plastocyanin reductase activity
ET495_RS06315	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ET495_RS06330	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ET495_RS06335	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ET495_RS06370	COG0667	Aldo Keto reductase
ET495_RS06390	COG0167	dihydroorotate dehydrogenase activity
ET495_RS06405	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ET495_RS06410	COG0508	dehydrogenase complex catalyzes the overall conversion of
ET495_RS06435	COG0673	inositol 2-dehydrogenase activity
ET495_RS06440	COG0321	lipoyl(octanoyl) transferase activity
ET495_RS06445	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ET495_RS06475	COG0174	glutamine synthetase
ET495_RS06540	COG3022	response to hydroperoxide
ET495_RS06555	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ET495_RS06565	COG0659	secondary active sulfate transmembrane transporter activity
ET495_RS06580	COG1309	transcriptional regulator
ET495_RS06585	COG1131	(ABC) transporter
ET495_RS06595	COG0514	ATP-dependent DNA helicase (RecQ)
ET495_RS06605	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ET495_RS06610	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ET495_RS06655	COG3328	transposase activity
ET495_RS06690	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
ET495_RS06710	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ET495_RS06715	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ET495_RS06720	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ET495_RS06790	COG5006	permease, DMT superfamily
ET495_RS06795	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ET495_RS06800	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ET495_RS06815	COG0477	Major facilitator Superfamily
ET495_RS06825	COG0358	DNA primase activity
ET495_RS06835	COG4499	WXG100 protein secretion system (Wss), protein YukC
ET495_RS06835	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ET495_RS06870	COG0366	Alpha amylase catalytic
ET495_RS06875	COG3833	ABC-type maltose transport systems, permease component
ET495_RS06880	COG1175	transmembrane transport
ET495_RS06895	COG0366	Alpha amylase catalytic
ET495_RS06930	COG3764	Sortase (surface protein transpeptidase)
ET495_RS06940	COG2197	response regulator
ET495_RS06945	COG4585	Histidine kinase
ET495_RS06950	COG0842	Transport permease protein
ET495_RS06965	COG0765	amino acid transport
ET495_RS06985	COG0423	glycine-tRNA ligase activity
ET495_RS06990	COG3443	Belongs to the bacterial solute-binding protein 9 family
ET495_RS06990	COG0803	Belongs to the bacterial solute-binding protein 9 family
ET495_RS06995	COG1121	(ABC) transporter
ET495_RS07010	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ET495_RS07015	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ET495_RS07020	COG1120	ATPase activity
ET495_RS07035	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ET495_RS07040	COG1381	Involved in DNA repair and RecF pathway recombination
ET495_RS07045	COG0740	serine-type endopeptidase activity
ET495_RS07050	COG0740	serine-type endopeptidase activity
ET495_RS07055	COG1396	sequence-specific DNA binding
ET495_RS07065	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ET495_RS07085	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ET495_RS07095	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ET495_RS07105	COG0537	adenosine 5'-monophosphoramidase activity
ET495_RS07115	COG0484	heat shock protein binding
ET495_RS07120	COG1420	regulation of RNA biosynthetic process
ET495_RS07125	COG3619	membrane
ET495_RS07130	COG0747	negative chemotaxis
ET495_RS07140	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ET495_RS07190	COG0481	GTPase activity
ET495_RS07200	COG1305	Transglutaminase-like
ET495_RS07230	COG0366	Alpha amylase catalytic
ET495_RS07235	COG0268	Binds directly to 16S ribosomal RNA
ET495_RS07255	COG1307	EDD domain protein, DegV family
ET495_RS07260	COG0433	COG0433 Predicted ATPase
ET495_RS07325	COG2814	Major facilitator Superfamily
ET495_RS07345	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
ET495_RS07350	COG2357	RelA SpoT domain protein
ET495_RS07380	COG0579	oxidoreductase
ET495_RS07395	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ET495_RS07395	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ET495_RS07400	COG2409	Drug exporters of the RND superfamily
ET495_RS07410	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ET495_RS07415	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
ET495_RS07420	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
ET495_RS07425	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ET495_RS07445	COG1126	abc transporter atp-binding protein
ET495_RS07450	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ET495_RS07455	COG0765	amino acid transport
ET495_RS07460	COG4215	(ABC) transporter
ET495_RS07470	COG0446	pyridine nucleotide-disulphide oxidoreductase
ET495_RS07475	COG0640	Transcriptional regulator
ET495_RS07495	COG1121	(ABC) transporter
ET495_RS07500	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ET495_RS07525	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
ET495_RS07535	COG0673	inositol 2-dehydrogenase activity
ET495_RS07545	COG2188	Transcriptional regulator
ET495_RS07605	COG1070	Carbohydrate kinase
ET495_RS07615	COG1349	DNA-binding transcription factor activity
ET495_RS07620	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ET495_RS07625	COG0066	3-isopropylmalate dehydratase activity
ET495_RS07635	COG1414	Transcriptional regulator
ET495_RS07670	COG0546	phosphoglycolate phosphatase activity
ET495_RS07675	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ET495_RS07685	COG0179	Fumarylacetoacetate (FAA) hydrolase
ET495_RS07725	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ET495_RS07740	COG0095	Lipoate-protein ligase
ET495_RS07745	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ET495_RS07750	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ET495_RS07755	COG0473	3-isopropylmalate dehydrogenase activity
ET495_RS07760	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
ET495_RS07765	COG0440	acetolactate synthase activity
ET495_RS07775	COG2154	pterin-4-alpha-carbinolamine dehydratase
ET495_RS07790	COG0129	dihydroxy-acid dehydratase activity
ET495_RS07795	COG3104	oligopeptide transport
ET495_RS07805	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ET495_RS07810	COG0154	amidase activity
ET495_RS07815	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ET495_RS07825	COG1414	Transcriptional regulator
ET495_RS07830	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
ET495_RS07865	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ET495_RS07870	COG1012	belongs to the aldehyde dehydrogenase family
ET495_RS07870	COG1454	alcohol dehydrogenase
ET495_RS07875	COG1505	serine-type exopeptidase activity
ET495_RS07885	COG0482	sulfurtransferase activity
ET495_RS07895	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
ET495_RS07915	COG0366	Alpha amylase catalytic
ET495_RS07925	COG3281	Trehalose synthase
ET495_RS07930	COG2252	PERMEase
ET495_RS07935	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
ET495_RS07960	COG2267	carboxylic ester hydrolase activity
ET495_RS07975	COG0545	Peptidyl-prolyl cis-trans isomerase
ET495_RS07995	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
ET495_RS08015	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ET495_RS08080	COG2197	response regulator
ET495_RS08105	COG2801	Transposase and inactivated derivatives
ET495_RS08110	COG2826	transposase and inactivated derivatives, IS30 family
ET495_RS08150	COG5002	protein histidine kinase activity
ET495_RS08155	COG0745	RESPONSE REGULATOR receiver
ET495_RS08160	COG1968	undecaprenyl-diphosphatase activity
ET495_RS08165	COG0390	transport system, permease component
ET495_RS08205	COG1136	(ABC) transporter
ET495_RS08205	COG0577	efflux transmembrane transporter activity
ET495_RS08240	COG0739	heme binding
ET495_RS08335	COG2197	response regulator
ET495_RS08395	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ET495_RS08405	COG1780	Probably involved in ribonucleotide reductase function
ET495_RS08420	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ET495_RS08425	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
ET495_RS08435	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ET495_RS08440	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
ET495_RS08445	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ET495_RS08450	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ET495_RS08455	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ET495_RS08470	COG0356	it plays a direct role in the translocation of protons across the membrane
ET495_RS08490	COG2890	protein-(glutamine-N5) methyltransferase activity
ET495_RS08495	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ET495_RS08500	COG0254	rRNA binding
ET495_RS08515	COG0083	homoserine kinase activity
ET495_RS08520	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ET495_RS08525	COG0460	homoserine dehydrogenase
ET495_RS08530	COG0019	diaminopimelate decarboxylase activity
ET495_RS08535	COG0018	arginyl-trna synthetase
ET495_RS08560	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
ET495_RS08595	COG0745	RESPONSE REGULATOR receiver
ET495_RS08600	COG2205	protein histidine kinase activity
ET495_RS08605	COG0567	Dehydrogenase, E1 component
ET495_RS08605	COG0508	dehydrogenase complex catalyzes the overall conversion of
ET495_RS08610	COG0667	Aldo Keto reductase
ET495_RS08635	COG5662	AntiSigma factor
ET495_RS08640	COG1595	DNA-templated transcription, initiation
ET495_RS08650	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ET495_RS08655	COG1162	GTPase activity
ET495_RS08660	COG0483	inositol monophosphate 1-phosphatase activity
ET495_RS08670	COG0280	phosphate acetyltransferase
ET495_RS08670	COG0857	belongs to the CobB CobQ family
ET495_RS08675	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
ET495_RS08700	COG1454	alcohol dehydrogenase
ET495_RS08700	COG1012	belongs to the aldehyde dehydrogenase family
ET495_RS08710	COG4302	ethanolamine ammonia-lyase activity
ET495_RS08715	COG4303	Ethanolamine ammonia lyase large subunit
ET495_RS08725	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
ET495_RS08740	COG3845	ABC transporter
ET495_RS08760	COG2211	Major facilitator Superfamily
ET495_RS08795	COG0653	protein targeting
ET495_RS08800	COG3214	Protein conserved in bacteria
ET495_RS08805	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ET495_RS08810	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ET495_RS08820	COG5002	protein histidine kinase activity
ET495_RS08825	COG0745	RESPONSE REGULATOR receiver
ET495_RS08840	COG0714	Associated with various cellular activities
ET495_RS08875	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
ET495_RS08915	COG0438	transferase activity, transferring glycosyl groups
ET495_RS08925	COG0489	protein tyrosine kinase activity
ET495_RS08950	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ET495_RS09035	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
ET495_RS09045	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
ET495_RS09050	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
ET495_RS09050	COG0662	Cupin 2, conserved barrel domain protein
ET495_RS09085	COG0438	transferase activity, transferring glycosyl groups
ET495_RS09110	COG1216	Glycosyl transferase, family 2
ET495_RS09110	COG0438	transferase activity, transferring glycosyl groups
ET495_RS09130	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ET495_RS09170	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ET495_RS09200	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
ET495_RS09215	COG0463	Glycosyl transferase, family 2
ET495_RS09265	COG1088	dTDP-glucose 4,6-dehydratase activity
ET495_RS09270	COG1316	TRANSCRIPTIONal
ET495_RS09280	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ET495_RS09295	COG2205	protein histidine kinase activity
ET495_RS09300	COG0745	RESPONSE REGULATOR receiver
ET495_RS09305	COG4585	Histidine kinase
ET495_RS09310	COG2197	response regulator
ET495_RS09315	COG0577	efflux transmembrane transporter activity
ET495_RS09315	COG1136	(ABC) transporter
ET495_RS09360	COG0395	ABC-type sugar transport system, permease component
ET495_RS09365	COG2723	6-phospho-beta-galactosidase activity
ET495_RS09375	COG3459	Glycosyltransferase 36 associated
ET495_RS09380	COG0531	amino acid
ET495_RS09385	COG1012	belongs to the aldehyde dehydrogenase family
ET495_RS09395	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ET495_RS09400	COG2890	protein-(glutamine-N5) methyltransferase activity
ET495_RS09405	COG3253	May function as heme-dependent peroxidase
ET495_RS09410	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ET495_RS09425	COG1929	Belongs to the glycerate kinase type-1 family
ET495_RS09435	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ET495_RS09445	COG1722	exodeoxyribonuclease VII activity
ET495_RS09455	COG0114	fumarate hydratase activity
ET495_RS09470	COG0444	Belongs to the ABC transporter superfamily
ET495_RS09480	COG0601	transmembrane transport
ET495_RS09495	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
ET495_RS09505	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ET495_RS09520	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
ET495_RS09530	COG2197	response regulator
ET495_RS09535	COG4585	Histidine kinase
ET495_RS09545	COG1960	acyl-CoA dehydrogenase activity
ET495_RS09595	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ET495_RS09625	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ET495_RS09635	COG2720	vancomycin resistance protein
ET495_RS09660	COG2186	Transcriptional regulator
ET495_RS09670	COG1172	Belongs to the binding-protein-dependent transport system permease family
ET495_RS09690	COG4948	Mandelate Racemase Muconate Lactonizing
ET495_RS09695	COG0179	Fumarylacetoacetate (FAA) hydrolase
ET495_RS09700	COG1028	Short-chain dehydrogenase reductase Sdr
ET495_RS09705	COG0247	lactate metabolic process
ET495_RS09710	COG1139	Iron-sulfur cluster binding protein
ET495_RS09715	COG1556	Lactate utilization protein
ET495_RS09740	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ET495_RS09790	COG3850	Histidine kinase
ET495_RS09795	COG2197	response regulator
ET495_RS09810	COG2885	chlorophyll binding
ET495_RS09985	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ET495_RS10085	COG0739	heme binding
ET495_RS10085	COG0741	lytic transglycosylase activity
ET495_RS10085	COG1196	nuclear chromosome segregation
ET495_RS10235	COG1970	mechanosensitive ion channel activity
ET495_RS10250	COG2814	Major facilitator Superfamily
ET495_RS10255	COG0577	efflux transmembrane transporter activity
ET495_RS10255	COG1136	(ABC) transporter
ET495_RS10270	COG2197	response regulator
ET495_RS10280	COG1940	carbohydrate kinase activity
ET495_RS10285	COG2115	Belongs to the xylose isomerase family
ET495_RS10290	COG1070	Carbohydrate kinase
ET495_RS10365	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ET495_RS10430	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
ET495_RS10435	COG2814	Major facilitator Superfamily
ET495_RS10440	COG1846	Transcriptional regulator
ET495_RS10455	COG2190	(PTS) system
ET495_RS10460	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ET495_RS10465	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ET495_RS10470	COG2188	Transcriptional regulator
ET495_RS10475	COG1263	PTS System
ET495_RS10480	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ET495_RS10485	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
ET495_RS10485	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ET495_RS10490	COG0363	glucosamine-6-phosphate deaminase activity
ET495_RS10505	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ET495_RS10510	COG1316	TRANSCRIPTIONal
ET495_RS10525	COG0438	transferase activity, transferring glycosyl groups
ET495_RS10555	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
ET495_RS10575	COG2252	PERMEase
ET495_RS10580	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ET495_RS10615	COG1278	Cold shock
ET495_RS10625	COG1061	Type III restriction enzyme res subunit
ET495_RS10635	COG1842	Phage shock protein A
ET495_RS10650	COG0745	RESPONSE REGULATOR receiver
ET495_RS10655	COG2205	protein histidine kinase activity
ET495_RS10670	COG0459	protein refolding
ET495_RS10690	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
ET495_RS10710	COG0515	serine threonine protein kinase
ET495_RS10710	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ET495_RS10715	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
ET495_RS10720	COG3842	ATPase activity
ET495_RS10735	COG0215	cysteine-tRNA ligase activity
ET495_RS10755	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ET495_RS10760	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ET495_RS10775	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ET495_RS10795	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ET495_RS10800	COG0581	inorganic phosphate transmembrane transporter activity
ET495_RS10815	COG0745	RESPONSE REGULATOR receiver
ET495_RS10820	COG5002	protein histidine kinase activity
ET495_RS10825	COG0704	Plays a role in the regulation of phosphate uptake
ET495_RS10830	COG0588	phosphoglycerate mutase activity
ET495_RS10845	COG0297	glycogen (starch) synthase activity
ET495_RS10865	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ET495_RS10895	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ET495_RS10900	COG0302	gtp cyclohydrolase
ET495_RS10905	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ET495_RS10915	COG0037	tRNA processing
ET495_RS10925	COG2027	D-alanyl-D-alanine carboxypeptidase
ET495_RS10930	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
ET495_RS10955	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ET495_RS10985	COG0391	Required for morphogenesis under gluconeogenic growth conditions
ET495_RS10990	COG1920	GTP binding
ET495_RS11000	COG0456	acetyltransferase
ET495_RS11000	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ET495_RS11005	COG0277	FAD linked oxidase domain protein
ET495_RS11005	COG0247	lactate metabolic process
ET495_RS11010	COG1764	response to oxidative stress
ET495_RS11035	COG1490	D-aminoacyl-tRNA deacylase activity
ET495_RS11060	COG4129	membrane
ET495_RS11070	COG3485	protocatechuate 3,4-dioxygenase
ET495_RS11085	COG2353	YceI-like domain
ET495_RS11095	COG0745	RESPONSE REGULATOR receiver
ET495_RS11100	COG0596	Alpha beta hydrolase
ET495_RS11130	COG1408	metallophosphoesterase
ET495_RS11175	COG1063	alcohol dehydrogenase
ET495_RS11230	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ET495_RS11300	COG0584	glycerophosphoryl diester phosphodiesterase
ET495_RS11315	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ET495_RS11380	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ET495_RS11395	COG0737	Belongs to the 5'-nucleotidase family
ET495_RS11410	COG2116	formate transmembrane transporter activity
ET495_RS11420	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ET495_RS11430	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ET495_RS11440	COG1403	HNH endonuclease
ET495_RS11455	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ET495_RS11465	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ET495_RS11470	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ET495_RS11495	COG4172	Belongs to the ABC transporter superfamily
ET495_RS11500	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ET495_RS11505	COG0601	transmembrane transport
ET495_RS11510	COG0747	negative chemotaxis
ET495_RS11520	COG2838	Isocitrate dehydrogenase
ET495_RS11550	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ET495_RS11570	COG0183	Belongs to the thiolase family
ET495_RS11580	COG2030	dehydratase
ET495_RS11605	COG0154	amidase activity
ET495_RS11635	COG0318	PFAM AMP-dependent synthetase and ligase
ET495_RS11705	COG1780	Probably involved in ribonucleotide reductase function
ET495_RS11710	COG0535	radical SAM domain protein
ET495_RS11715	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ET495_RS11725	COG0047	phosphoribosylformylglycinamidine synthase activity
ET495_RS11760	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
ET495_RS11765	COG0151	Belongs to the GarS family
ET495_RS11775	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ET495_RS11840	COG0586	Pfam SNARE associated Golgi protein
ET495_RS11850	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ET495_RS11860	COG0300	oxidoreductase activity
ET495_RS11895	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ET495_RS11900	COG0601	transmembrane transport
ET495_RS11905	COG0747	negative chemotaxis
ET495_RS11935	COG1063	alcohol dehydrogenase
ET495_RS11940	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ET495_RS11965	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ET495_RS11965	COG2169	Transcriptional regulator
ET495_RS11985	COG0651	ATP synthesis coupled electron transport
ET495_RS11990	COG1006	Multisubunit Na H antiporter MnhC subunit
ET495_RS11995	COG2111	Na H antiporter
ET495_RS11995	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ET495_RS12005	COG0717	Belongs to the dCTP deaminase family
ET495_RS12040	COG2909	trisaccharide binding
ET495_RS12055	COG1082	Xylose isomerase domain protein TIM barrel
ET495_RS12060	COG2190	(PTS) system
ET495_RS12070	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
ET495_RS12075	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ET495_RS12075	COG0574	Belongs to the PEP-utilizing enzyme family
ET495_RS12090	COG0656	L-ascorbic acid biosynthetic process
ET495_RS12110	COG2409	Drug exporters of the RND superfamily
ET495_RS12125	COG0508	dehydrogenase complex catalyzes the overall conversion of
ET495_RS12130	COG0022	dehydrogenase e1 component
ET495_RS12140	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ET495_RS12145	COG1950	PFAM Membrane protein of
ET495_RS12160	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ET495_RS12170	COG3711	transcriptional antiterminator
ET495_RS12190	COG2801	Transposase and inactivated derivatives
ET495_RS12225	COG0395	ABC-type sugar transport system, permease component
ET495_RS12230	COG1175	transmembrane transport
ET495_RS12235	COG1653	transport
ET495_RS12255	COG0561	phosphatase activity
ET495_RS12260	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ET495_RS12275	COG1215	transferase activity, transferring glycosyl groups
ET495_RS12315	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ET495_RS12320	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ET495_RS12325	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ET495_RS12335	COG0181	hydroxymethylbilane synthase activity
ET495_RS12345	COG0113	porphobilinogen synthase activity
ET495_RS12350	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ET495_RS12355	COG1937	Protein conserved in bacteria
ET495_RS12385	COG0601	transmembrane transport
ET495_RS12430	COG2197	response regulator
ET495_RS12450	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
ET495_RS12485	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
ET495_RS12500	COG3591	Belongs to the peptidase S1B family
ET495_RS12500	COG1864	DNA RNA non-specific endonuclease
ET495_RS12515	COG1966	Carbon starvation protein
ET495_RS12535	COG0601	transmembrane transport
ET495_RS12545	COG2318	DinB family
ET495_RS12585	COG1834	amidinotransferase
ET495_RS12600	COG0477	Major facilitator Superfamily
ET495_RS12630	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
ET495_RS12645	COG2239	Acts as a magnesium transporter
ET495_RS12650	COG0028	Belongs to the TPP enzyme family
ET495_RS12745	COG0583	DNA-binding transcription factor activity
ET495_RS12750	COG1028	Short-chain dehydrogenase reductase Sdr
ET495_RS12760	COG2814	Major facilitator Superfamily
ET495_RS12780	COG0305	Participates in initiation and elongation during chromosome replication
ET495_RS12785	COG0534	Mate efflux family protein
ET495_RS12790	COG0359	binds to the 23S rRNA
ET495_RS12795	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ET495_RS12805	COG0360	Binds together with S18 to 16S ribosomal RNA
ET495_RS12815	COG1695	Transcriptional regulator
ET495_RS12820	COG1260	myo-inositol-1-phosphate synthase
ET495_RS12910	COG2814	Major facilitator Superfamily
ET495_RS12915	COG0617	tRNA 3'-terminal CCA addition
ET495_RS12945	COG0492	ferredoxin-NADP+ reductase activity
ET495_RS12950	COG3118	belongs to the thioredoxin family
ET495_RS12960	COG1181	Belongs to the D-alanine--D-alanine ligase family
ET495_RS12970	COG1192	Involved in chromosome partitioning
ET495_RS12975	COG0357	Ribosomal RNA small subunit methyltransferase G
ET495_RS12990	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
ET495_RS12995	COG0594	ribonuclease P activity
ET495_RS13000	COG0230	Belongs to the bacterial ribosomal protein bL34 family
ET495_RS13005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ET495_RS13010	COG0592	DNA-directed DNA polymerase activity
ET495_RS13015	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
ET495_RS13025	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
ET495_RS13030	COG0187	DNA topoisomerase II activity
ET495_RS13035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ET495_RS13055	COG2205	protein histidine kinase activity
ET495_RS13060	COG0745	RESPONSE REGULATOR receiver
ET495_RS13075	COG2326	polyphosphate kinase activity
ET495_RS13105	COG3764	Sortase (surface protein transpeptidase)
ET495_RS13120	COG0515	serine threonine protein kinase
ET495_RS13140	COG1716	ATPase activity
ET495_RS13170	COG2197	response regulator
ET495_RS13195	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ET495_RS13220	COG0436	Aminotransferase
ET495_RS13255	COG0404	The glycine cleavage system catalyzes the degradation of glycine
ET495_RS13260	COG0509	glycine decarboxylation via glycine cleavage system
ET495_RS13275	COG0738	Major facilitator superfamily
ET495_RS13290	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
ET495_RS13300	COG0318	PFAM AMP-dependent synthetase and ligase
ET495_RS13300	COG0204	Acyl-transferase
ET495_RS13315	COG2818	Glycosylase
ET495_RS13340	COG2885	chlorophyll binding
ET495_RS13345	COG1301	dicarboxylic acid transport
ET495_RS13350	COG3290	protein histidine kinase activity
ET495_RS13355	COG4565	transcriptional regulatory protein
ET495_RS13360	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
ET495_RS13380	COG0442	prolyl-tRNA aminoacylation
ET495_RS13410	COG0765	amino acid transport
ET495_RS13435	COG1278	Cold shock
ET495_RS13505	COG3012	SEC-C Motif Domain Protein
ET495_RS13510	COG2814	Major facilitator Superfamily
ET495_RS13530	COG1937	Protein conserved in bacteria
ET495_RS13580	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ET495_RS13590	COG1309	transcriptional regulator
ET495_RS13595	COG1131	(ABC) transporter
ET495_RS13630	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ET495_RS13635	COG0300	oxidoreductase activity
ET495_RS13645	COG0406	alpha-ribazole phosphatase activity
ET495_RS13670	COG3265	gluconokinase activity
ET495_RS13700	COG1053	succinate dehydrogenase
ET495_RS13740	COG1857	crispr-associated protein
ET495_RS13760	COG3328	transposase activity
ET495_RS13765	COG3328	transposase activity
ET495_RS13795	COG0604	alcohol dehydrogenase
ET495_RS13805	COG2018	Roadblock/LC7 domain
ET495_RS13875	COG0166	Belongs to the GPI family
ET495_RS13885	COG1609	Transcriptional regulator
ET495_RS13895	COG1175	transmembrane transport
ET495_RS13905	COG1472	Belongs to the glycosyl hydrolase 3 family
ET495_RS13955	COG0375	protein maturation
ET495_RS13965	COG0298	carbon dioxide binding
ET495_RS13975	COG0375	protein maturation
ET495_RS13980	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
ET495_RS13985	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
ET495_RS13990	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
ET495_RS14000	COG3338	carbonate dehydratase activity
ET495_RS14005	COG0298	carbon dioxide binding
ET495_RS14020	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
ET495_RS14040	COG1028	Short-chain dehydrogenase reductase Sdr
ET495_RS14065	COG0443	Heat shock 70 kDa protein
ET495_RS14075	COG0484	heat shock protein binding
ET495_RS14080	COG0789	Transcriptional regulator
ET495_RS14095	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
ET495_RS14100	COG0590	tRNA wobble adenosine to inosine editing
ET495_RS14110	COG1132	(ABC) transporter
ET495_RS14150	COG1715	Restriction endonuclease
ET495_RS14215	COG0395	ABC-type sugar transport system, permease component
ET495_RS14220	COG1175	transmembrane transport
ET495_RS14235	COG1609	Transcriptional regulator
ET495_RS14245	COG0438	transferase activity, transferring glycosyl groups
ET495_RS14265	COG1960	acyl-CoA dehydrogenase activity
ET495_RS14270	COG3201	nicotinamide mononucleotide transporter
ET495_RS14275	COG1309	transcriptional regulator
ET495_RS14285	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
ET495_RS14295	COG2233	PERMEase
ET495_RS14325	COG1028	Short-chain dehydrogenase reductase Sdr
ET495_RS14330	COG1028	Short-chain dehydrogenase reductase Sdr
ET495_RS14355	COG1464	Belongs to the NlpA lipoprotein family
ET495_RS14360	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ET495_RS14365	COG2011	ABC-type metal ion transport system permease component
ET495_RS14375	COG0494	nUDIX hydrolase
ET495_RS14390	COG1172	Belongs to the binding-protein-dependent transport system permease family
ET495_RS14395	COG4213	ABC transporter substrate-binding protein
ET495_RS14410	COG1609	Transcriptional regulator
ET495_RS14420	COG1175	transmembrane transport
ET495_RS14425	COG0395	ABC-type sugar transport system, permease component
ET495_RS14430	COG1653	transport
ET495_RS14440	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ET495_RS14455	COG0598	Magnesium transport protein CorA
ET495_RS14460	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ET495_RS14485	COG2329	Antibiotic biosynthesis monooxygenase
ET495_RS14550	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ET495_RS14565	COG1846	Transcriptional regulator
ET495_RS14590	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
ET495_RS14605	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ET495_RS14610	COG1902	pentaerythritol trinitrate reductase activity
ET495_RS14660	COG0596	Alpha beta hydrolase
ET495_RS14675	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
ET495_RS14680	COG2318	DinB family
ET495_RS14705	COG1754	DNA topoisomerase type I activity
ET495_RS14705	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ET495_RS14715	COG0577	efflux transmembrane transporter activity
ET495_RS14715	COG1136	(ABC) transporter
ET495_RS14725	COG1104	cysteine desulfurase activity
ET495_RS14735	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
ET495_RS14740	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
ET495_RS14790	COG0242	peptide deformylase activity
ET495_RS14800	COG0589	response to stress
ET495_RS14825	COG0395	ABC-type sugar transport system, permease component
ET495_RS14855	COG4209	transmembrane transport
ET495_RS14860	COG0395	ABC-type sugar transport system, permease component
ET495_RS14875	COG1609	Transcriptional regulator
ET495_RS14910	COG2186	Transcriptional regulator
ET495_RS14920	COG0667	Aldo Keto reductase
ET495_RS14925	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ET495_RS14935	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ET495_RS14940	COG2354	Protein conserved in bacteria
ET495_RS14945	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
ET495_RS14980	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ET495_RS14985	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ET495_RS14990	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
ET495_RS15005	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
ET495_RS15010	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
ET495_RS15025	COG1609	Transcriptional regulator
ET495_RS15040	COG2160	L-arabinose isomerase activity
ET495_RS15080	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ET495_RS15085	COG0569	domain protein
ET495_RS15090	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ET495_RS15095	COG0123	including yeast histone deacetylase and acetoin utilization protein
ET495_RS15115	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
ET495_RS15130	COG0406	alpha-ribazole phosphatase activity
ET495_RS15140	COG0785	Cytochrome C biogenesis protein
ET495_RS15150	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ET495_RS15175	COG1470	cell adhesion involved in biofilm formation
ET495_RS15210	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
ET495_RS15215	COG4948	Mandelate Racemase Muconate Lactonizing
ET495_RS15220	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
ET495_RS15225	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ET495_RS15245	COG0534	Mate efflux family protein
ET495_RS15250	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ET495_RS15265	COG1136	(ABC) transporter
ET495_RS15275	COG2226	methyltransferase
ET495_RS15285	COG2197	response regulator
ET495_RS15295	COG1136	(ABC) transporter
ET495_RS15300	COG0577	efflux transmembrane transporter activity
ET495_RS15300	COG1136	(ABC) transporter
ET495_RS15315	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ET495_RS15325	COG0649	NAD binding
ET495_RS15340	COG1034	ATP synthesis coupled electron transport
ET495_RS15350	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ET495_RS15355	COG0839	Belongs to the complex I subunit 6 family
ET495_RS15360	COG0713	ATP synthesis coupled electron transport
ET495_RS15365	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ET495_RS15375	COG1007	ATP synthesis coupled electron transport
ET495_RS15380	COG0142	geranyltranstransferase activity
ET495_RS15390	COG2885	chlorophyll binding
ET495_RS15405	COG0631	protein serine/threonine phosphatase activity
ET495_RS15445	COG2885	chlorophyll binding
ET495_RS15490	COG3850	Histidine kinase
ET495_RS15495	COG2197	response regulator
ET495_RS15510	COG2885	chlorophyll binding
ET495_RS15540	COG0501	Belongs to the peptidase M48B family
ET495_RS15555	COG0561	phosphatase activity
ET495_RS15560	COG1666	GTP binding
ET495_RS15580	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ET495_RS15585	COG2030	dehydratase
ET495_RS15600	COG2223	nitrite transmembrane transporter activity
ET495_RS15605	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ET495_RS15615	COG0251	oxidation-reduction process
ET495_RS15620	COG0179	Fumarylacetoacetate (FAA) hydrolase
ET495_RS15625	COG1946	Acyl-CoA thioesterase
ET495_RS15645	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ET495_RS15650	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ET495_RS15660	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
ET495_RS15680	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
ET495_RS15690	COG3851	Histidine kinase
ET495_RS15715	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ET495_RS15725	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ET495_RS15730	COG0081	regulation of translation
ET495_RS15750	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ET495_RS15755	COG0222	ribosome binding
ET495_RS15760	COG0085	RNA polymerase activity
ET495_RS15770	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ET495_RS15775	COG0049	tRNA binding
ET495_RS15780	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ET495_RS15785	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ET495_RS15790	COG0051	transcription antitermination factor activity, RNA binding
ET495_RS15795	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ET495_RS15800	COG0088	Forms part of the polypeptide exit tunnel
ET495_RS15805	COG0089	rRNA binding
ET495_RS15810	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ET495_RS15815	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ET495_RS15820	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ET495_RS15825	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ET495_RS15830	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ET495_RS15835	COG0255	Belongs to the universal ribosomal protein uL29 family
ET495_RS15840	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ET495_RS15845	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ET495_RS15850	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
ET495_RS15855	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ET495_RS15860	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ET495_RS15865	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ET495_RS15870	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
ET495_RS15880	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ET495_RS15885	COG1841	ribosomal large subunit assembly
ET495_RS15890	COG0200	Binds to the 23S rRNA
ET495_RS15895	COG0201	protein transport
ET495_RS15900	COG0563	adenylate kinase activity
ET495_RS15910	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ET495_RS15915	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ET495_RS15920	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ET495_RS15925	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ET495_RS15930	COG0202	RNA polymerase activity
ET495_RS15935	COG0203	ribosomal protein L17
ET495_RS15945	COG1940	carbohydrate kinase activity
ET495_RS15950	COG0101	tRNA pseudouridine synthase activity
ET495_RS15965	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ET495_RS15970	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ET495_RS15980	COG0242	peptide deformylase activity
ET495_RS15995	COG1072	(Pantothenic acid kinase))
ET495_RS16000	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ET495_RS16005	COG0736	holo-[acyl-carrier-protein] synthase activity
ET495_RS16010	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ET495_RS16035	COG0386	Belongs to the glutathione peroxidase family
ET495_RS16040	COG0564	pseudouridine synthase activity
ET495_RS16055	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ET495_RS16060	COG0802	atpase or kinase
ET495_RS16070	COG0456	acetyltransferase
ET495_RS16080	COG0778	Nitroreductase
ET495_RS16085	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ET495_RS16105	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
ET495_RS16130	COG0516	GMP reductase activity
ET495_RS16135	COG1012	belongs to the aldehyde dehydrogenase family
ET495_RS16150	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ET495_RS16160	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
ET495_RS16170	COG1132	(ABC) transporter
ET495_RS16175	COG1132	(ABC) transporter
ET495_RS16185	COG0519	Catalyzes the synthesis of GMP from XMP
ET495_RS16185	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ET495_RS16210	COG2197	response regulator
ET495_RS16275	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ET495_RS16280	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ET495_RS16295	COG1832	CoA-binding protein
ET495_RS16305	COG1136	(ABC) transporter
ET495_RS16305	COG0577	efflux transmembrane transporter activity
ET495_RS16310	COG1136	(ABC) transporter
ET495_RS16310	COG0577	efflux transmembrane transporter activity
ET495_RS16350	COG0039	L-malate dehydrogenase activity
ET495_RS16395	COG4213	ABC transporter substrate-binding protein
ET495_RS16405	COG4214	carbohydrate transport
ET495_RS16415	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ET495_RS16420	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ET495_RS16435	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
ET495_RS16450	COG0745	RESPONSE REGULATOR receiver
ET495_RS16455	COG2205	protein histidine kinase activity
ET495_RS16470	COG2239	Acts as a magnesium transporter
ET495_RS16480	COG0006	proline dipeptidase activity
ET495_RS16500	COG0698	ribose 5-phosphate isomerase
ET495_RS16510	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ET495_RS16580	COG0513	Belongs to the DEAD box helicase family
ET495_RS16610	COG2816	NAD+ diphosphatase activity
ET495_RS16655	COG1615	UPF0182 protein
ET495_RS16675	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
ET495_RS16680	COG0457	Tetratricopeptide repeat
ET495_RS16685	COG2169	Transcriptional regulator
ET495_RS16685	COG1917	Cupin 2, conserved barrel domain protein
ET495_RS16690	COG1609	Transcriptional regulator
ET495_RS16700	COG0395	ABC-type sugar transport system, permease component
ET495_RS16720	COG1070	Carbohydrate kinase
ET495_RS16735	COG5426	von Willebrand factor, type A
ET495_RS16740	COG1454	alcohol dehydrogenase
ET495_RS16815	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ET495_RS16820	COG2011	ABC-type metal ion transport system permease component
ET495_RS16825	COG1464	Belongs to the NlpA lipoprotein family
ET495_RS16855	COG1028	Short-chain dehydrogenase reductase Sdr
ET495_RS16860	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
ET495_RS16870	COG1653	transport
ET495_RS16875	COG1175	transmembrane transport
ET495_RS16880	COG0395	ABC-type sugar transport system, permease component
ET495_RS16920	COG0681	Belongs to the peptidase S26 family
ET495_RS16935	COG0183	Belongs to the thiolase family
ET495_RS16945	COG1250	3-hydroxyacyl-CoA dehydrogenase
ET495_RS16950	COG2050	protein possibly involved in aromatic compounds catabolism
ET495_RS16955	COG1012	belongs to the aldehyde dehydrogenase family
ET495_RS16955	COG2030	dehydratase
ET495_RS16970	COG2050	protein possibly involved in aromatic compounds catabolism
ET495_RS16975	COG3396	Phenylacetate-CoA oxygenase
ET495_RS16980	COG3460	Phenylacetate-CoA oxygenase
ET495_RS16985	COG3396	Phenylacetate-CoA oxygenase
ET495_RS16990	COG2151	metal-sulfur cluster biosynthetic enzyme
ET495_RS16995	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ET495_RS17035	COG1175	transmembrane transport
ET495_RS17080	COG1136	(ABC) transporter
ET495_RS17130	COG1335	isochorismatase
ET495_RS17145	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ET495_RS17150	COG0084	hydrolase, TatD family'
ET495_RS17175	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ET495_RS17180	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ET495_RS17185	COG3458	cephalosporin-C deacetylase activity
ET495_RS17190	COG0488	(ABC) transporter
ET495_RS17210	COG1136	(ABC) transporter
ET495_RS17210	COG0577	efflux transmembrane transporter activity
ET495_RS17240	COG2807	transmembrane transport
ET495_RS17245	COG1846	Transcriptional regulator
ET495_RS17290	COG0741	lytic transglycosylase activity
ET495_RS17295	COG0791	NLP P60 protein
ET495_RS17365	COG1475	DNA binding
ET495_RS17410	COG2184	nucleotidyltransferase activity