locus-tag	class	description
ET495_RS00010	ENOG4108IUX	(ABC) transporter
ET495_RS00015	ENOG41067SE	Tetr family transcriptional regulator
ET495_RS00025	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
ET495_RS00030	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
ET495_RS00040	ENOG4107XT7	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
ET495_RS00045	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
ET495_RS00065	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
ET495_RS00075	ENOG4107EF8	Glycosyl transferase (Group 1
ET495_RS00115	ENOG4108UHC	Glycosyl transferase, wecb taga cpsf family
ET495_RS00130	ENOG4105D9F	endo-1,4-beta-xylanase (EC 3.2.1.8)
ET495_RS00140	ENOG4105C19	ABC transporter
ET495_RS00150	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
ET495_RS00170	ENOG4105C87	Aminotransferase class I and II
ET495_RS00270	ENOG4105CHZ	Catalyzes the dehydration of D-mannonate (By similarity)
ET495_RS00275	ENOG4105DEI	Mannitol dehydrogenase
ET495_RS00290	ENOG4105D2H	Uronic isomerase
ET495_RS00295	ENOG4105D8J	Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity)
ET495_RS00315	ENOG41089UC	methyltransferase, type 11
ET495_RS00320	ENOG4107QXP	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
ET495_RS00335	ENOG4105C7B	Threonine dehydratase
ET495_RS00340	ENOG4107YD5	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
ET495_RS00350	ENOG4105T1M	mycothiol conjugate amidase mca
ET495_RS00365	ENOG4105DVS	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
ET495_RS00370	ENOG4105C48	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
ET495_RS00395	ENOG4105C3G	gtp-binding protein
ET495_RS00415	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
ET495_RS00445	ENOG4108JQ6	ABC transporter
ET495_RS00450	ENOG4105CI3	gtp-binding protein typa
ET495_RS00455	ENOG4108KZ5	Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity)
ET495_RS00475	ENOG4105CQC	Prephenate dehydratase
ET495_RS00490	ENOG4108Z4U	Ferredoxin
ET495_RS00520	ENOG4107R4C	succinyl-diaminopimelate desuccinylase
ET495_RS00540	ENOG4107ZBN	O-methyltransferase
ET495_RS00555	ENOG4105UTW	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity)
ET495_RS00560	ENOG4105C31	Tryptophanyl-tRNA synthetase
ET495_RS00585	ENOG4105D5G	Transposase
ET495_RS00605	ENOG4105E33	succinate dehydrogenase
ET495_RS00625	ENOG4105CJT	Mannose-1-phosphate guanylyltransferase
ET495_RS00635	ENOG4105DIH	basic membrane
ET495_RS00645	ENOG4105UIB	(ABC) transporter
ET495_RS00675	ENOG4105EKD	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity)
ET495_RS00710	ENOG410650H	(LipO)protein
ET495_RS00735	ENOG4108JIK	carboxylase
ET495_RS00740	ENOG4107WR6	Maf-like protein
ET495_RS00745	ENOG4105RK9	auxin efflux carrier
ET495_RS00765	ENOG4105D8K	carboxyl transferase
ET495_RS00785	ENOG4108KGH	TRANSCRIPTIONal
ET495_RS00825	ENOG4105CG1	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity)
ET495_RS00835	ENOG4107RYD	Part of the ABC transporter FtsEX involved in cellular division (By similarity)
ET495_RS00845	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
ET495_RS00860	ENOG4105E2R	ROK family
ET495_RS00880	ENOG41061DF	Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P (By similarity)
ET495_RS00885	ENOG4105CKA	Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity)
ET495_RS00905	ENOG4105E2V	Glycosyltransferase 36
ET495_RS00910	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
ET495_RS00915	ENOG4105KEN	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity)
ET495_RS00925	ENOG4105F03	Provides the (R)-glutamate required for cell wall biosynthesis (By similarity)
ET495_RS00945	ENOG4105ED0	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity)
ET495_RS00960	ENOG41080RH	Thioredoxin
ET495_RS00985	ENOG4105D82	Glutamate dehydrogenase
ET495_RS01005	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
ET495_RS01040	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
ET495_RS01050	ENOG4105CEY	Amp-dependent synthetase and ligase
ET495_RS01055	ENOG4105CPF	Cell wall formation (By similarity)
ET495_RS01075	ENOG4105VB9	50S ribosomal protein l28
ET495_RS01080	ENOG4105DP4	dak2 domain fusion protein ylov
ET495_RS01090	ENOG4106H78	methyltransferase
ET495_RS01095	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
ET495_RS01110	ENOG41084BZ	50S ribosomal protein L32
ET495_RS01115	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
ET495_RS01120	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
ET495_RS01130	ENOG4108JJ8	(ABC) transporter
ET495_RS01135	ENOG4108JJ9	ABC, transporter
ET495_RS01140	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
ET495_RS01145	ENOG4105C4M	(Ubiquinol oxidase) subunit I
ET495_RS01155	ENOG4105C03	ribonuclease
ET495_RS01160	ENOG4107T8J	thymidine kinase
ET495_RS01170	ENOG410826X	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
ET495_RS01175	ENOG4105K46	50S ribosomal protein l27
ET495_RS01180	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ET495_RS01190	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
ET495_RS01200	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
ET495_RS01205	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
ET495_RS01215	ENOG4105KEM	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity)
ET495_RS01220	ENOG4105CVJ	phosphoglycerate mutase
ET495_RS01250	ENOG4105CHR	reductase
ET495_RS01255	ENOG4105CHU	acetyl-coa acetyltransferase
ET495_RS01285	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
ET495_RS01335	ENOG4105C26	Dehydrogenase
ET495_RS01340	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
ET495_RS01345	ENOG4107RSM	transcriptional regulator
ET495_RS01355	ENOG4105E5Q	amino acid AbC transporter
ET495_RS01360	ENOG4108JEH	abc transporter atp-binding protein
ET495_RS01365	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
ET495_RS01370	ENOG4105EHG	Permease protein
ET495_RS01375	ENOG4108IPX	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity)
ET495_RS01400	ENOG4105C10	Electron transfer flavoprotein
ET495_RS01420	ENOG4107QN1	sodium solute
ET495_RS01430	ENOG4105E2D	ec 3.2.1.52
ET495_RS01440	ENOG4108RBP	3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity)
ET495_RS01465	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
ET495_RS01600	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
ET495_RS01625	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
ET495_RS01650	ENOG4105D8X	mechanosensitive ion channel
ET495_RS01715	ENOG4105D7W	serine acetyltransferase
ET495_RS01725	ENOG4105DCT	glycerol dehydrogenase
ET495_RS01750	ENOG4105DIV	Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD( ) and coenzyme A. Is the final enzyme in the meta- cleavage pathway for the degradation of aromatic compounds (By similarity)
ET495_RS01815	ENOG4107HP6	Transcriptional regulator
ET495_RS01830	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
ET495_RS01835	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
ET495_RS01840	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
ET495_RS01845	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
ET495_RS01850	ENOG4108IQE	Amp-dependent synthetase and ligase
ET495_RS01855	ENOG4105EHE	chorismate mutase- prephenate dehydrogenase
ET495_RS01870	ENOG4105EAB	amino acid AbC transporter
ET495_RS01875	ENOG4105DRP	amino acid AbC transporter
ET495_RS01880	ENOG4105CDA	abc transporter atp-binding protein
ET495_RS01890	ENOG41088YA	Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives (By similarity)
ET495_RS01940	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
ET495_RS01945	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
ET495_RS01950	ENOG4105CMT	Dihydroxyacetone kinase
ET495_RS01970	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
ET495_RS01985	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
ET495_RS02015	ENOG4105K5M	30s ribosomal protein S16
ET495_RS02020	ENOG41082KU	UPF0109 protein
ET495_RS02025	ENOG4107XUM	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
ET495_RS02030	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
ET495_RS02035	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
ET495_RS02040	ENOG4107QYR	Signal peptidase i
ET495_RS02045	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
ET495_RS02055	ENOG41080R2	UPF0102 protein
ET495_RS02070	ENOG4108IYT	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
ET495_RS02080	ENOG4105CE9	30S ribosomal protein S2
ET495_RS02085	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
ET495_RS02090	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
ET495_RS02095	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
ET495_RS02125	ENOG4105CEA	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)
ET495_RS02135	ENOG4108UV6	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
ET495_RS02140	ENOG4105C4U	4-methyl-5-beta-hydroxyethylthiazole kinase
ET495_RS02150	ENOG4105DZP	Membrane-associated zinc metalloprotease
ET495_RS02155	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
ET495_RS02175	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
ET495_RS02185	ENOG4107Z1I	Required for maturation of 30S ribosomal subunits (By similarity)
ET495_RS02205	ENOG4107ZPY	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
ET495_RS02210	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
ET495_RS02225	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
ET495_RS02230	ENOG4108RH7	phosphoglycerate mutase
ET495_RS02235	ENOG4105CEY	Amp-dependent synthetase and ligase
ET495_RS02270	ENOG4108QIU	Dehydrogenase
ET495_RS02280	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
ET495_RS02285	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
ET495_RS02290	ENOG4105C1V	Peptidase, M16
ET495_RS02295	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
ET495_RS02315	ENOG4108RTV	Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity)
ET495_RS02365	ENOG4105CEV	competence damage-inducible protein
ET495_RS02370	ENOG4105WBV	Transcriptional regulator
ET495_RS02395	ENOG4107KFM	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
ET495_RS02400	ENOG4105KC9	Modulates RecA activity (By similarity)
ET495_RS02405	ENOG4105DRP	amino acid AbC transporter
ET495_RS02410	ENOG4108Q1T	ABC transporter
ET495_RS02415	ENOG4107UBR	Extracellular solute-binding protein family 3
ET495_RS02420	ENOG4105CDA	abc transporter atp-binding protein
ET495_RS02425	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
ET495_RS02455	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
ET495_RS02460	ENOG4105E4Z	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)
ET495_RS02465	ENOG4107Y49	methyltransferase
ET495_RS02470	ENOG41069M3	Transcriptional regulator
ET495_RS02485	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
ET495_RS02500	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
ET495_RS02505	ENOG41067Z0	domain protein
ET495_RS02510	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
ET495_RS02515	ENOG4108JQ1	Dehydrogenase
ET495_RS02530	ENOG4105VEQ	Cold shock protein
ET495_RS02565	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
ET495_RS02570	ENOG4108V6E	Cell division protein mraZ
ET495_RS02575	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
ET495_RS02585	ENOG4105CJN	penicillin-binding protein
ET495_RS02600	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
ET495_RS02605	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
ET495_RS02615	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
ET495_RS02620	ENOG4105DFU	Cell wall formation (By similarity)
ET495_RS02630	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
ET495_RS02640	ENOG4105VR5	Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity)
ET495_RS02650	ENOG4105XWG	Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity)
ET495_RS02675	ENOG4105C0B	DNA polymerase III (alpha subunit)
ET495_RS02690	ENOG4105WQ3	Rna-binding protein
ET495_RS02695	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
ET495_RS02705	ENOG4107XR4	alpha beta
ET495_RS02725	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
ET495_RS02735	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
ET495_RS02765	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
ET495_RS02770	ENOG41084BS	50S ribosomal protein L35
ET495_RS02775	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
ET495_RS02780	ENOG4105C2N	RNA methyltransferase TrmH family group 3
ET495_RS02790	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
ET495_RS02800	ENOG4105DT9	hydrolase family 43
ET495_RS02810	ENOG4105EE6	Alcohol dehydrogenase zinc-binding domain protein
ET495_RS02815	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
ET495_RS02820	ENOG4105C5V	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity)
ET495_RS02825	ENOG4105CAS	nag kinase
ET495_RS02830	ENOG4105C8Y	Acetylornithine aminotransferase
ET495_RS02840	ENOG4105XBY	Regulates arginine biosynthesis genes (By similarity)
ET495_RS02845	ENOG4105CH7	arginosuccinase
ET495_RS02855	ENOG4108VX5	3-methyladenine DNA glycosylase
ET495_RS02910	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
ET495_RS02935	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
ET495_RS02985	ENOG4105JRK	feS assembly protein SufD
ET495_RS02995	ENOG4105C3K	feS assembly ATPase SufC
ET495_RS03005	ENOG4108UNV	SUF system FeS assembly protein, NifU family
ET495_RS03010	ENOG4105VG1	fes assembly suf system protein
ET495_RS03035	ENOG410839S	Toxic component of a toxin-antitoxin (TA) module (By similarity)
ET495_RS03040	ENOG4105E0A	ABC, transporter
ET495_RS03050	ENOG4105S6R	Iron-hydroxamate transporter permease subunit
ET495_RS03080	ENOG4105KDC	50s ribosomal protein l28
ET495_RS03085	ENOG4105W0E	50S ribosomal protein L33
ET495_RS03090	ENOG41080FR	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
ET495_RS03095	ENOG4105NRA	50s ribosomal protein l31 type b
ET495_RS03100	ENOG4108638	50S ribosomal protein L36
ET495_RS03120	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
ET495_RS03165	ENOG4105C5H	ABC transporter
ET495_RS03225	ENOG4105DKW	ABC transporter
ET495_RS03285	ENOG4108V1U	phospholipid-binding protein
ET495_RS03360	ENOG4105D5G	Transposase
ET495_RS03380	ENOG4105EYG	tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity)
ET495_RS03425	ENOG4105BZK	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity)
ET495_RS03435	ENOG4105D5G	Transposase
ET495_RS03460	ENOG4105D5G	Transposase
ET495_RS03490	ENOG4107ZVI	PhiRv2 prophage protein
ET495_RS03520	ENOG4105C5H	ABC transporter
ET495_RS03525	ENOG4105CHJ	isochorismatase hydrolase
ET495_RS03530	ENOG4108TKW	Glyoxalase Bleomycin resistance protein (Dioxygenase
ET495_RS03540	ENOG4105DGW	oligopeptidase A
ET495_RS03545	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
ET495_RS03560	ENOG4107SET	aldo keto reductase
ET495_RS03570	ENOG4105C8N	cysteinyl-tRNA synthetase
ET495_RS03600	ENOG4105DHM	ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity)
ET495_RS03605	ENOG4105E5F	proteasome
ET495_RS03610	ENOG4105WFD	Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation (By similarity)
ET495_RS03615	ENOG4105KPK	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity)
ET495_RS03625	ENOG4105DVV	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine (By similarity)
ET495_RS03640	ENOG4105BZ1	(ABC) transporter
ET495_RS03645	ENOG4105BZ1	(ABC) transporter
ET495_RS03650	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
ET495_RS03670	ENOG4105DK0	Indole-3-glycerol phosphate synthase
ET495_RS03675	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
ET495_RS03680	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
ET495_RS03685	ENOG4107TBN	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
ET495_RS03690	ENOG4105CBC	glutamate synthase
ET495_RS03745	ENOG4108YRB	methyltransferase
ET495_RS03755	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
ET495_RS03780	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
ET495_RS03805	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
ET495_RS03830	ENOG4105E5G	Alpha beta hydrolase fold
ET495_RS03870	ENOG4105C21	Displays ATPase and GTPase activities (By similarity)
ET495_RS03875	ENOG4105CHW	UPF0052 protein
ET495_RS03880	ENOG4108IQE	Amp-dependent synthetase and ligase
ET495_RS03890	ENOG4105CIE	May be required for sporulation (By similarity)
ET495_RS03895	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
ET495_RS03900	ENOG4105BZA	Phosphoglycerate kinase
ET495_RS03920	ENOG4107XU2	6-phosphogluconolactonase (EC 3.1.1.31)
ET495_RS03935	ENOG4107QQX	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
ET495_RS03945	ENOG4105F1R	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity)
ET495_RS03960	ENOG4108KVX	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity)
ET495_RS03965	ENOG4105K8I	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity)
ET495_RS04015	ENOG4105D5G	Transposase
ET495_RS04030	ENOG4105D5G	Transposase
ET495_RS04065	ENOG4105EGI	Transcriptional regulator
ET495_RS04100	ENOG4105DA5	(ABC) transporter
ET495_RS04110	ENOG4105CJ1	ABC, transporter
ET495_RS04120	ENOG4105C0A	alcohol dehydrogenase
ET495_RS04180	ENOG4105EWI	Short-chain dehydrogenase reductase Sdr
ET495_RS04190	ENOG4107YAQ	Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity)
ET495_RS04195	ENOG4105D2B	acyl-CoA dehydrogenase
ET495_RS04205	ENOG4105CHR	reductase
ET495_RS04210	ENOG4105CEY	Amp-dependent synthetase and ligase
ET495_RS04225	ENOG4105CSH	Transporter
ET495_RS04240	ENOG4105CEU	Arginine dihydrolase
ET495_RS04245	ENOG4105CHU	acetyl-coa acetyltransferase
ET495_RS04260	ENOG4108JU9	GAF modulated sigma54 specific transcriptional regulator Fis family
ET495_RS04265	ENOG4107SZ9	Hydantoinase oxoprolinase
ET495_RS04270	ENOG4105RQI	acetone carboxylase gamma subunit
ET495_RS04275	ENOG4107RID	5-oxoprolinase (ATP-hydrolyzing)
ET495_RS04320	ENOG4108UIN	ybak prolyl-trna synthetase associated region
ET495_RS04325	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
ET495_RS04335	ENOG4105CHR	reductase
ET495_RS04340	ENOG4105E98	transcriptional regulator DeoR family
ET495_RS04355	ENOG4105DM4	PTS System
ET495_RS04370	ENOG4105CJW	magnesium transporter
ET495_RS04375	ENOG410834F	Transcriptional regulator
ET495_RS04400	ENOG4105DRP	amino acid AbC transporter
ET495_RS04405	ENOG4105E5Q	amino acid AbC transporter
ET495_RS04435	ENOG4108JPZ	Monovalent cation H antiporter subunit D
ET495_RS04460	ENOG41080EA	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
ET495_RS04470	ENOG4107RWR	Sodium hydrogen exchanger
ET495_RS04515	ENOG4105VSY	K01512 acylphosphatase EC 3.6.1.7
ET495_RS04530	ENOG4105BZ1	(ABC) transporter
ET495_RS04535	ENOG4105BZ1	(ABC) transporter
ET495_RS04540	ENOG4107R3N	Filamentation induced by cAMP protein fic
ET495_RS04545	ENOG4105DND	Transcriptional regulator
ET495_RS04550	ENOG4107RTD	sua5 ycio yrdc ywlc family protein
ET495_RS04565	ENOG4108ZK7	protein family UPF0029, Impact, N-terminal protein
ET495_RS04575	ENOG4108ZBR	Gcn5-related n-acetyltransferase
ET495_RS04580	ENOG4105DPV	During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction
ET495_RS04595	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
ET495_RS04615	ENOG4108FFZ	Transcriptional regulator
ET495_RS04630	ENOG41067S4	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
ET495_RS04635	ENOG4105DCX	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)
ET495_RS04655	ENOG4105CI2	imidazolone-5-propionate hydrolase
ET495_RS04665	ENOG4106N3V	dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83)
ET495_RS04705	ENOG4105CDH	Citrulline--aspartate ligase
ET495_RS04725	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
ET495_RS04770	ENOG4108UW8	fha domain-containing protein
ET495_RS04805	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
ET495_RS04810	ENOG4105M0N	phosphoribosyl-ATP pyrophosphatase
ET495_RS04815	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
ET495_RS04820	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
ET495_RS04825	ENOG4108R6K	riboflavin synthase, subunit alpha
ET495_RS04835	ENOG4105DJV	ribulose-phosphate 3-epimerase
ET495_RS04845	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
ET495_RS04860	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
ET495_RS04870	ENOG4105MTQ	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
ET495_RS04875	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
ET495_RS04880	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
ET495_RS04890	ENOG4105SKN	orotidine 5''-phosphate decarboxylase
ET495_RS04895	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
ET495_RS04900	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
ET495_RS04910	ENOG4105CD3	dihydroorotase
ET495_RS04915	ENOG4105CXT	aspartate transcarbamylase
ET495_RS04920	ENOG4108UK1	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity)
ET495_RS04925	ENOG410803B	Involved in the transcription termination process (By similarity)
ET495_RS04930	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
ET495_RS04945	ENOG4107VXZ	Hydrolase
ET495_RS04950	ENOG4108Z38	Catalyzes a trans-dehydration via an enolate intermediate (By similarity)
ET495_RS04965	ENOG4105DMF	Dehydrogenase
ET495_RS04985	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
ET495_RS04990	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
ET495_RS04995	ENOG4105E2X	shikimate dehydrogenase
ET495_RS05000	ENOG4105HHA	aminodeoxychorismate lyase
ET495_RS05010	ENOG41080G3	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
ET495_RS05030	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
ET495_RS05040	ENOG4105ETE	Transcriptional regulator (LacI family
ET495_RS05045	ENOG4107R5G	Periplasmic binding protein LacI transcriptional regulator
ET495_RS05050	ENOG4105CNN	ABC, transporter
ET495_RS05055	ENOG4105C2J	ABC transporter
ET495_RS05070	ENOG4105C9M	aspartyl-trna synthetase
ET495_RS05080	ENOG4105CUT	histidyl-tRNA synthetase
ET495_RS05115	ENOG4105C99	atpase involved in dna repair
ET495_RS05125	ENOG4105DQE	DNA ligase
ET495_RS05140	ENOG4109003	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity)
ET495_RS05145	ENOG4107RTU	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
ET495_RS05150	ENOG4107RSV	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
ET495_RS05160	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
ET495_RS05165	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
ET495_RS05170	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
ET495_RS05175	ENOG4105CDY	transcriptional regulatory protein
ET495_RS05180	ENOG4108UHX	Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity)
ET495_RS05185	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
ET495_RS05190	ENOG4105CD9	Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity)
ET495_RS05205	ENOG4107YQ3	lipid a biosynthesis lauroyl acyltransferase
ET495_RS05220	ENOG4105C22	threonyL-tRNA synthetase
ET495_RS05250	ENOG4108Z2X	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity)
ET495_RS05265	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
ET495_RS05270	ENOG4108JGH	Tetr family transcriptional regulator
ET495_RS05280	ENOG4105CEY	Amp-dependent synthetase and ligase
ET495_RS05310	ENOG4105JSC	dimethylmenaquinone methyltransferase
ET495_RS05315	ENOG4105CSH	Transporter
ET495_RS05320	ENOG4105QPS	Monooxygenase
ET495_RS05325	ENOG4105C26	Dehydrogenase
ET495_RS05330	ENOG4105DA5	(ABC) transporter
ET495_RS05340	ENOG4105CJ1	ABC, transporter
ET495_RS05385	ENOG4105D7K	pfkb domain protein
ET495_RS05390	ENOG4107QKS	N-acylglucosamine 2-epimerase
ET495_RS05415	ENOG4105ETE	Transcriptional regulator (LacI family
ET495_RS05420	ENOG4105E2R	ROK family
ET495_RS05450	ENOG4108MXD	gtp-binding protein
ET495_RS05500	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
ET495_RS05530	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
ET495_RS05535	ENOG4105C4B	ABC transporter, permease
ET495_RS05555	ENOG4108KD5	ADP-ribosylation crystallin J1
ET495_RS05590	ENOG410836F	Transposase
ET495_RS05595	ENOG410836F	Transposase
ET495_RS05600	ENOG410836F	Transposase
ET495_RS05605	ENOG4105H9W	Short-chain dehydrogenase reductase Sdr
ET495_RS05610	ENOG4105D5G	Transposase
ET495_RS05625	ENOG4105D5G	Transposase
ET495_RS05645	ENOG4105CRQ	synthase (Component I)
ET495_RS05685	ENOG4105CSR	polyphosphate kinase 2
ET495_RS05725	ENOG4105C7Q	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity)
ET495_RS05740	ENOG4105CHU	acetyl-coa acetyltransferase
ET495_RS05750	ENOG4105F1A	Pyruvate formate-lyase
ET495_RS05765	ENOG4105ERX	Dehydrogenase
ET495_RS05770	ENOG4105EEM	helicase
ET495_RS05770	ENOG4105EEM	helicase
ET495_RS05775	ENOG4105P8F	nudix hydrolase
ET495_RS05795	ENOG4108M15	ABC transporter
ET495_RS05800	ENOG4107QM5	aconitate hydratase
ET495_RS05820	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
ET495_RS05825	ENOG4105C0X	amino acid
ET495_RS05830	ENOG4107VEG	TrkA-N domain protein
ET495_RS05875	ENOG4105EN6	Membrane
ET495_RS05885	ENOG4107W53	thymidine kinase
ET495_RS05920	ENOG4108J2P	Alpha beta hydrolase fold
ET495_RS05940	ENOG4105CE1	Ferrous iron transport protein b
ET495_RS05950	ENOG4105C3R	Methionine synthase
ET495_RS05980	ENOG410839S	Toxic component of a toxin-antitoxin (TA) module (By similarity)
ET495_RS06010	ENOG41061P8	Persistence to inhibition of murein or DNA biosynthesis regulatory protein
ET495_RS06035	ENOG4105C32	Amino acid ABC transporter (Permease)
ET495_RS06040	ENOG4108IV0	ABC, transporter
ET495_RS06045	ENOG4105C0Z	ABC transporter
ET495_RS06085	ENOG4106UW1	Major Facilitator superfamily
ET495_RS06090	ENOG41080T7	secreted protein
ET495_RS06095	ENOG4105DBE	peroxidase
ET495_RS06125	ENOG410836F	Transposase
ET495_RS06195	ENOG4107ZVI	PhiRv2 prophage protein
ET495_RS06215	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
ET495_RS06220	ENOG4105SHT	UspA domain-containing protein
ET495_RS06235	ENOG4105EAH	synthase
ET495_RS06250	ENOG4105C7V	phospho-2-dehydro-3-deoxyheptonate aldolase
ET495_RS06270	ENOG4105DKQ	ROK family
ET495_RS06290	ENOG4108I0Q	anthranilate phosphoribosyltransferase
ET495_RS06300	ENOG4105CCU	oxidase (Subunit III)
ET495_RS06305	ENOG4107UDY	cytochrome C
ET495_RS06310	ENOG4107EUI	c reductase, iron-sulfur
ET495_RS06315	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
ET495_RS06325	ENOG4105MCD	Part of cytochrome c oxidase, its function is
ET495_RS06330	ENOG4105BZ9	Cytochrome C oxidase, subunit I
ET495_RS06335	ENOG4105CV4	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity)
ET495_RS06360	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
ET495_RS06370	ENOG4105CPC	Aldo Keto reductase
ET495_RS06390	ENOG4107QYT	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity)
ET495_RS06405	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
ET495_RS06435	ENOG4105D9R	oxidoreductase
ET495_RS06440	ENOG4108BDP	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
ET495_RS06445	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
ET495_RS06475	ENOG4105C5F	glutamine synthetase
ET495_RS06510	ENOG4105CHR	reductase
ET495_RS06540	ENOG4107XFJ	UPF0246 protein
ET495_RS06555	ENOG4105EGD	dinuclear metal center protein, YbgI family
ET495_RS06565	ENOG4105CHH	sulfate transporter
ET495_RS06585	ENOG4105CJ1	ABC, transporter
ET495_RS06595	ENOG4105C9U	ATP-dependent DNA helicase RecQ
ET495_RS06605	ENOG41085J0	Protein CrcB homolog
ET495_RS06610	ENOG41083TI	Protein CrcB homolog
ET495_RS06655	ENOG4105D5G	Transposase
ET495_RS06690	ENOG4105DAQ	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity)
ET495_RS06710	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
ET495_RS06715	ENOG41082KT	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
ET495_RS06730	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
ET495_RS06790	ENOG4107AQZ	Membrane
ET495_RS06795	ENOG4108MES	Periplasmic binding protein
ET495_RS06800	ENOG4105DHS	permease protein
ET495_RS06815	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
ET495_RS06825	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
ET495_RS06830	ENOG4105C4Q	deoxyguanosinetriphosphate triphosphohydrolase-like protein
ET495_RS06835	ENOG4105BZ4	penicillin-binding protein
ET495_RS06870	ENOG4107R28	alpha amylase, catalytic region
ET495_RS06875	ENOG4105EG2	ABC transporter, permease
ET495_RS06880	ENOG4105D56	permease protein
ET495_RS06895	ENOG4105CG3	alpha amylase, catalytic region
ET495_RS06930	ENOG4108Z6X	(sortase) family
ET495_RS06945	ENOG4105BZU	Histidine kinase
ET495_RS06950	ENOG4105KCT	ABC transporter
ET495_RS06960	ENOG4106PMH	Extracellular solute-binding protein family 3
ET495_RS06965	ENOG4105DRP	amino acid AbC transporter
ET495_RS06985	ENOG4105D9H	Catalyzes the attachment of glycine to tRNA(Gly) (By similarity)
ET495_RS06990	ENOG4105DSE	periplasmic solute binding protein
ET495_RS06995	ENOG4105FDK	ABC transporter
ET495_RS07010	ENOG4105DQ5	transport system permease protein
ET495_RS07015	ENOG4105TVJ	transport system, permease
ET495_RS07020	ENOG4105E0A	ABC, transporter
ET495_RS07035	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
ET495_RS07040	ENOG4106DBE	Involved in DNA repair and RecF pathway recombination (By similarity)
ET495_RS07045	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
ET495_RS07050	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
ET495_RS07055	ENOG4105WBV	Transcriptional regulator
ET495_RS07065	ENOG4107QXN	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
ET495_RS07085	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
ET495_RS07095	ENOG4107VNR	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
ET495_RS07105	ENOG4107YU2	histidine triad (hIT) protein
ET495_RS07115	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
ET495_RS07120	ENOG4105CI8	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity)
ET495_RS07125	ENOG4105XPP	Protein of unknown function (DUF1275)
ET495_RS07130	ENOG4105DEF	Extracellular solute-binding protein, family 5
ET495_RS07140	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
ET495_RS07150	ENOG4108JQ6	ABC transporter
ET495_RS07190	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
ET495_RS07230	ENOG4108IUK	alpha amylase, catalytic
ET495_RS07235	ENOG4105KQV	Binds directly to 16S ribosomal RNA (By similarity)
ET495_RS07255	ENOG4105EPR	degv family
ET495_RS07260	ENOG4105D7A	ATP-binding protein
ET495_RS07270	ENOG4105C26	Dehydrogenase
ET495_RS07315	ENOG4105C8T	Leucyl-tRNA synthetase
ET495_RS07325	ENOG4105F27	Major Facilitator
ET495_RS07345	ENOG4105FDF	Could be involved in DNA repair (By similarity)
ET495_RS07380	ENOG4105DWT	malate dehydrogenase (quinone)
ET495_RS07400	ENOG4107WA4	MmpL domain-containing protein
ET495_RS07410	ENOG4108NKJ	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity)
ET495_RS07415	ENOG4105C15	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
ET495_RS07420	ENOG4108IIE	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
ET495_RS07425	ENOG4107VBM	3-beta hydroxysteroid dehydrogenase isomerase
ET495_RS07435	ENOG41080HT	Transcriptional regulator, arsr family
ET495_RS07445	ENOG4105CDA	abc transporter atp-binding protein
ET495_RS07450	ENOG4105EAB	amino acid AbC transporter
ET495_RS07455	ENOG4105EAD	ABC transporter
ET495_RS07460	ENOG4105GBT	ABC transporter
ET495_RS07470	ENOG4107QMW	pyridine nucleotide-disulfide oxidoreductase
ET495_RS07475	ENOG4105KTU	Transcriptional regulator, arsr family
ET495_RS07495	ENOG4105DIK	(ABC) transporter
ET495_RS07500	ENOG4105CC5	ABC transporter
ET495_RS07525	ENOG4105FCI	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity)
ET495_RS07535	ENOG4105DRI	Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity)
ET495_RS07545	ENOG4105FDP	GntR family transcriptional regulator
ET495_RS07605	ENOG4105CMG	Carbohydrate kinase
ET495_RS07615	ENOG4105MVE	transcriptional regulator
ET495_RS07620	ENOG4105DYW	oxidoreductase
ET495_RS07625	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
ET495_RS07635	ENOG41069M3	Transcriptional regulator
ET495_RS07670	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
ET495_RS07675	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
ET495_RS07685	ENOG4105ERH	Fumarylacetoacetate hydrolase
ET495_RS07725	ENOG4108Z66	YbaK ebsC protein
ET495_RS07735	ENOG4105DFA	alanine racemase domain protein
ET495_RS07740	ENOG4105DF9	Lipoate-protein, ligase
ET495_RS07745	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
ET495_RS07750	ENOG4105CM2	brancheD-chain amino acid aminotransferase
ET495_RS07755	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
ET495_RS07760	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
ET495_RS07765	ENOG4108ZP8	Acetolactate synthase small subunit
ET495_RS07775	ENOG4105KZX	Pterin carbinolamine dehydratase
ET495_RS07790	ENOG4105C01	Dihydroxy-acid dehydratase
ET495_RS07795	ENOG4105DUX	Transporter
ET495_RS07805	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
ET495_RS07810	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
ET495_RS07815	ENOG41081AP	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
ET495_RS07825	ENOG41069M3	Transcriptional regulator
ET495_RS07830	ENOG4107R9S	Malate synthase
ET495_RS07865	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
ET495_RS07870	ENOG4105C0A	alcohol dehydrogenase
ET495_RS07885	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
ET495_RS07895	ENOG4105C10	Electron transfer flavoprotein
ET495_RS07915	ENOG4105EP6	Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity)
ET495_RS07925	ENOG41070F3	Catalyzes the ATP-dependent phosphorylation of maltose to maltose 1-phosphate. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, GlgE and GlgB (By similarity)
ET495_RS07930	ENOG4105C7N	Xanthine uracil vitamin C permease
ET495_RS07935	ENOG4105C9C	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity)
ET495_RS07960	ENOG4107S9D	Alpha beta hydrolase
ET495_RS07975	ENOG4108V1T	peptidylprolyl cis-trans isomerase
ET495_RS07995	ENOG41076CZ	activating enzyme
ET495_RS08015	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
ET495_RS08080	ENOG4105WH1	Two component transcriptional regulator luxr family
ET495_RS08110	ENOG4105F9F	transposase
ET495_RS08150	ENOG4105BZU	Histidine kinase
ET495_RS08155	ENOG4105ETX	regulatoR
ET495_RS08160	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
ET495_RS08165	ENOG4105C4B	ABC transporter, permease
ET495_RS08205	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
ET495_RS08240	ENOG4105DR5	peptidase
ET495_RS08335	ENOG4105WH1	Two component transcriptional regulator luxr family
ET495_RS08395	ENOG4105E05	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
ET495_RS08405	ENOG4105G3E	Probably involved in ribonucleotide reductase function (By similarity)
ET495_RS08420	ENOG4105CE4	GlcNAc 6-P deacetylase
ET495_RS08425	ENOG4105CYV	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity)
ET495_RS08435	ENOG410825K	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
ET495_RS08440	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
ET495_RS08445	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
ET495_RS08450	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
ET495_RS08455	ENOG4108T62	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
ET495_RS08460	ENOG4107Z0K	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity)
ET495_RS08470	ENOG4107UH5	it plays a direct role in the translocation of protons across the membrane (By similarity)
ET495_RS08490	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
ET495_RS08495	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
ET495_RS08500	ENOG4105VFB	Binds the 23S rRNA (By similarity)
ET495_RS08515	ENOG4105D5I	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity)
ET495_RS08520	ENOG4107R5I	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity)
ET495_RS08525	ENOG4105D6E	homoserine dehydrogenase
ET495_RS08530	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
ET495_RS08535	ENOG4105C75	arginyL-tRNA synthetase
ET495_RS08560	ENOG4105CR4	methylisocitrate lyase
ET495_RS08595	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
ET495_RS08600	ENOG4105EB3	Histidine kinase
ET495_RS08605	ENOG4105C7P	2-oxoglutarate dehydrogenase, E1
ET495_RS08610	ENOG4107SET	aldo keto reductase
ET495_RS08640	ENOG4105EMN	RNA polymerase sigma factor
ET495_RS08650	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
ET495_RS08655	ENOG4105E06	May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity)
ET495_RS08660	ENOG4107TK4	histidinol-phosphate phosphatase
ET495_RS08670	ENOG4105C6K	Malic enzyme
ET495_RS08680	ENOG4107YMV	ethanolamine utilization protein
ET495_RS08690	ENOG4105NDK	ethanolamine utilization protein
ET495_RS08695	ENOG4105KNY	Microcompartments protein
ET495_RS08700	ENOG4105C0A	alcohol dehydrogenase
ET495_RS08705	ENOG4106D67	ethanolamine utilization protein
ET495_RS08710	ENOG4107FQ9	ethanolamine ammonia-lyase
ET495_RS08715	ENOG4105CPD	ethanolamine ammonia-lyase
ET495_RS08720	ENOG4105DYY	Reactivating factor for ethanolamine ammonia lyase
ET495_RS08725	ENOG4105WVM	ethanolamine utilization protein EutN carboxysome structural protein Ccml
ET495_RS08730	ENOG4105ENY	Ethanolamine utilization protein eutH
ET495_RS08740	ENOG4108JJB	ABC transporter
ET495_RS08760	ENOG4105CT4	transporter
ET495_RS08795	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
ET495_RS08800	ENOG4105T0Z	Conserved Protein
ET495_RS08805	ENOG4108S7Q	sigma 54 modulation protein ribosomal protein S30ea
ET495_RS08810	ENOG4109003	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity)
ET495_RS08820	ENOG4105BZU	Histidine kinase
ET495_RS08825	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
ET495_RS08835	ENOG4108WQ6	secreted protein
ET495_RS08840	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
ET495_RS08875	ENOG4105C3E	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity)
ET495_RS08885	ENOG4105D3Q	Sugar transferase
ET495_RS08890	ENOG4105D3Q	Sugar transferase
ET495_RS08915	ENOG4105JNK	Glycosyl transferase (Group 1
ET495_RS08925	ENOG4107YJ4	chain length determinant protein
ET495_RS08950	ENOG4107QKV	phosphomannomutase
ET495_RS08955	ENOG4105EIP	mannose-6-phosphate isomerase
ET495_RS08995	ENOG4105K51	Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity)
ET495_RS09035	ENOG4107QPT	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity)
ET495_RS09040	ENOG4105DBZ	Dtdp-4-dehydrorhamnose reductase
ET495_RS09045	ENOG4108URP	Dtdp-4-dehydrorhamnose 3,5-epimerase
ET495_RS09050	ENOG4105CJT	Mannose-1-phosphate guanylyltransferase
ET495_RS09085	ENOG4108NMT	An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity)
ET495_RS09115	ENOG4105C0K	Gdp-mannose 4,6-dehydratase
ET495_RS09120	ENOG4105C0K	Gdp-mannose 4,6-dehydratase
ET495_RS09130	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
ET495_RS09170	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
ET495_RS09205	ENOG4105DBZ	Dtdp-4-dehydrorhamnose reductase
ET495_RS09235	ENOG4108TJN	glycosyl transferase group 1
ET495_RS09240	ENOG4105MFV	ABC-2 type transporter
ET495_RS09245	ENOG4105EY8	ABC transporter
ET495_RS09265	ENOG4105C1B	dTDP-glucose 4-6-dehydratase
ET495_RS09270	ENOG4108KGH	TRANSCRIPTIONal
ET495_RS09280	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
ET495_RS09295	ENOG41065SU	Two-component system sensor kinase
ET495_RS09300	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
ET495_RS09305	ENOG4105BZU	Histidine kinase
ET495_RS09310	ENOG4105WH1	Two component transcriptional regulator luxr family
ET495_RS09315	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
ET495_RS09370	ENOG4105ETE	Transcriptional regulator (LacI family
ET495_RS09375	ENOG4105E2V	Glycosyltransferase 36
ET495_RS09380	ENOG4105CUB	amino acid
ET495_RS09385	ENOG4105C26	Dehydrogenase
ET495_RS09395	ENOG4105D82	Glutamate dehydrogenase
ET495_RS09400	ENOG4105C76	Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity)
ET495_RS09405	ENOG4107JTW	chlorite dismutase
ET495_RS09410	ENOG4107QME	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
ET495_RS09425	ENOG4105BZW	Glycerate kinase
ET495_RS09435	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
ET495_RS09445	ENOG4105YX8	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
ET495_RS09455	ENOG4105C9Q	fumarate hydratase class II
ET495_RS09470	ENOG4105C3U	ABC transporter
ET495_RS09490	ENOG4107QK4	glycoside hydrolase, family 3 domain protein
ET495_RS09495	ENOG4108IAB	Phoh family
ET495_RS09505	ENOG4105DRC	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
ET495_RS09520	ENOG4107R9S	Malate synthase
ET495_RS09530	ENOG4105WH1	Two component transcriptional regulator luxr family
ET495_RS09535	ENOG4105ENE	Histidine kinase
ET495_RS09545	ENOG4105CSU	acyl-Coa dehydrogenase
ET495_RS09590	ENOG4105DHU	Bile acid
ET495_RS09595	ENOG4105D7K	pfkb domain protein
ET495_RS09600	ENOG4108UHU	Aldolase
ET495_RS09610	ENOG41068KF	Universal stress protein
ET495_RS09625	ENOG4105NAE	bifunctional deaminase-reductase domain protein
ET495_RS09635	ENOG41073R8	VanW family
ET495_RS09660	ENOG4107YCY	Transcriptional regulator
ET495_RS09670	ENOG4105CNN	ABC, transporter
ET495_RS09690	ENOG4105DIA	mandelate racemase muconate lactonizing
ET495_RS09695	ENOG4105ERH	Fumarylacetoacetate hydrolase
ET495_RS09705	ENOG4105CHG	glycolate oxidase (iron-sulfur subunit)
ET495_RS09715	ENOG41080R8	Conserved Protein
ET495_RS09740	ENOG4108638	50S ribosomal protein L36
ET495_RS09790	ENOG4105BZU	Histidine kinase
ET495_RS09795	ENOG4105WH1	Two component transcriptional regulator luxr family
ET495_RS09810	ENOG4105F37	PsaA and PsaB bind P700, the primary electron donor of photosystem I (PSI), as well as the electron acceptors A0, A1 and FX. PSI is a plastocyanin cytochrome c6-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn. Oxidized P700 is reduced on the lumenal side of the thylakoid membrane by plastocyanin or cytochrome c6
ET495_RS09985	ENOG4107SID	ATP-dependent exodnase (exonuclease v)
ET495_RS10085	ENOG4105E4C	Lytic transglycosylase catalytic
ET495_RS10235	ENOG4105M2E	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity)
ET495_RS10250	ENOG4107SFI	Major Facilitator superfamily
ET495_RS10255	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
ET495_RS10285	ENOG4105C93	Xylose Isomerase
ET495_RS10365	ENOG4105XT2	Transcriptional regulator
ET495_RS10430	ENOG4107R8H	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity)
ET495_RS10435	ENOG4107SFI	Major Facilitator superfamily
ET495_RS10440	ENOG4105XMC	MarR family Transcriptional regulator
ET495_RS10455	ENOG4105C5Y	PTS System
ET495_RS10480	ENOG4105BZ3	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity)
ET495_RS10485	ENOG4105BZ3	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity)
ET495_RS10490	ENOG4105CKA	Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity)
ET495_RS10510	ENOG4108KGH	TRANSCRIPTIONal
ET495_RS10525	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
ET495_RS10575	ENOG4105C7N	Xanthine uracil vitamin C permease
ET495_RS10580	ENOG4105D3Q	Sugar transferase
ET495_RS10615	ENOG4105VEQ	Cold shock protein
ET495_RS10625	ENOG4105CFI	type iii restriction protein res subunit
ET495_RS10650	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
ET495_RS10655	ENOG4105BZU	Histidine kinase
ET495_RS10670	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
ET495_RS10690	ENOG4105D5S	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity)
ET495_RS10710	ENOG4108762	serine threonine protein kinase
ET495_RS10715	ENOG4105C1K	alpha-alpha-trehalose-phosphate synthase
ET495_RS10735	ENOG4105C8N	cysteinyl-tRNA synthetase
ET495_RS10755	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
ET495_RS10760	ENOG4105CE5	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity)
ET495_RS10775	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
ET495_RS10790	ENOG4107QJG	Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity)
ET495_RS10795	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
ET495_RS10800	ENOG4105E2Z	phosphate ABC transporter (Permease
ET495_RS10810	ENOG4107QJG	Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity)
ET495_RS10815	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
ET495_RS10820	ENOG4105BZU	Histidine kinase
ET495_RS10825	ENOG4108UTW	Plays a role in the regulation of phosphate uptake
ET495_RS10830	ENOG4107RPC	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
ET495_RS10845	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
ET495_RS10865	ENOG4105CRK	lysyL-tRNA synthetase
ET495_RS10895	ENOG4105EEI	dihydropteroate synthase
ET495_RS10900	ENOG4105EUJ	GTP cyclohydrolase i
ET495_RS10905	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
ET495_RS10915	ENOG4107RD1	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
ET495_RS10930	ENOG4105F0N	pyrophosphate phospho-hydrolase
ET495_RS10945	ENOG4108FKR	NLP P60 protein
ET495_RS10955	ENOG4105DWV	Homoserine O-trans-acetylase
ET495_RS11000	ENOG4108RTV	Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity)
ET495_RS11005	ENOG4105CQB	FAD linked oxidase domain protein
ET495_RS11010	ENOG4108Z9K	Osmotically inducible protein
ET495_RS11035	ENOG4108YYA	Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity)
ET495_RS11070	ENOG4108X6U	May play a role in the intracellular transport of hydrophobic ligands
ET495_RS11085	ENOG4108YYC	ycei family
ET495_RS11095	ENOG4107NHD	transcriptional regulator
ET495_RS11100	ENOG4105D74	hydrolase
ET495_RS11125	ENOG4105BZ4	penicillin-binding protein
ET495_RS11130	ENOG4105DIN	metallophosphoesterase
ET495_RS11175	ENOG4105CPQ	Dehydrogenase
ET495_RS11200	ENOG4105C0Z	ABC transporter
ET495_RS11205	ENOG4108IV0	ABC, transporter
ET495_RS11230	ENOG4105E99	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity)
ET495_RS11275	ENOG4107ZVI	PhiRv2 prophage protein
ET495_RS11300	ENOG4108QXE	glycerophosphoryl diester phosphodiesterase
ET495_RS11315	ENOG4105CMR	udp-glucose 4-epimerase
ET495_RS11325	ENOG4105C85	amino acid
ET495_RS11380	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
ET495_RS11395	ENOG4105CGH	5'-nucleotidase
ET495_RS11410	ENOG4105TMB	Formate nitrite transporter
ET495_RS11420	ENOG4105MXW	flavin reductase domain protein, FMN-binding
ET495_RS11455	ENOG4105FBW	Monooxygenase
ET495_RS11465	ENOG4105DEN	Luciferase family
ET495_RS11470	ENOG4105EAB	amino acid AbC transporter
ET495_RS11495	ENOG4108JQ6	ABC transporter
ET495_RS11500	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
ET495_RS11510	ENOG4107RNA	Nickel ABC transporter, periplasmic nickel-binding protein
ET495_RS11520	ENOG4105E9K	Isocitrate dehydrogenase
ET495_RS11550	ENOG4107QIK	phosphoribosylformylglycinamidine synthase
ET495_RS11570	ENOG4105CHU	acetyl-coa acetyltransferase
ET495_RS11575	ENOG4105CHR	reductase
ET495_RS11635	ENOG4105CEY	Amp-dependent synthetase and ligase
ET495_RS11705	ENOG4105G3E	Probably involved in ribonucleotide reductase function (By similarity)
ET495_RS11710	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
ET495_RS11715	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
ET495_RS11725	ENOG4105D21	Phosphoribosylformylglycinamidine synthase I
ET495_RS11760	ENOG4105C8V	SAICAR synthetase
ET495_RS11765	ENOG4105C12	Phosphoribosylglycinamide synthetase
ET495_RS11775	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
ET495_RS11840	ENOG4105DQR	SNARE associated Golgi
ET495_RS11850	ENOG41065E1	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
ET495_RS11860	ENOG4107FW0	short-chain dehydrogenase reductase
ET495_RS11885	ENOG4108MRH	transcriptional regulatory protein
ET495_RS11895	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
ET495_RS11905	ENOG4105DEF	Extracellular solute-binding protein, family 5
ET495_RS11935	ENOG4105CPQ	Dehydrogenase
ET495_RS11940	ENOG4108JQ0	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
ET495_RS11945	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
ET495_RS11965	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
ET495_RS11985	ENOG4108JPZ	Monovalent cation H antiporter subunit D
ET495_RS11990	ENOG4105MKQ	Monovalent cation H antiporter subunit C
ET495_RS11995	ENOG4105D65	subunit l
ET495_RS12005	ENOG4105DHP	deoxycytidine triphosphate deaminase
ET495_RS12015	ENOG4105EUB	pirin domain protein
ET495_RS12040	ENOG4108KQI	regulatory protein luxr
ET495_RS12055	ENOG4105EY0	Xylose isomerase domain protein TIM barrel
ET495_RS12060	ENOG4105C5Y	PTS System
ET495_RS12070	ENOG4105CF9	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity)
ET495_RS12075	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
ET495_RS12090	ENOG4105CV8	reductase
ET495_RS12110	ENOG4105EYF	MMPL domain protein
ET495_RS12125	ENOG4107RN0	branched-chain alpha-keto acid dehydrogenase subunit E2
ET495_RS12130	ENOG4105CPP	Dehydrogenase, E1 component
ET495_RS12140	ENOG4105CIH	Imidazole acetol-phosphate transaminase
ET495_RS12145	ENOG41082T9	Membrane
ET495_RS12160	ENOG4107QTF	adenylosuccinate lyase
ET495_RS12170	ENOG4105CID	antiterminator
ET495_RS12195	ENOG4105MP0	transposase
ET495_RS12225	ENOG4105EB1	binding-protein-dependent transport systems inner membrane Component
ET495_RS12230	ENOG4105S9S	Binding-protein-dependent transport systems, inner membrane component
ET495_RS12235	ENOG4105EPJ	extracellular solute-binding protein family 1
ET495_RS12255	ENOG4108KP7	hydrolase
ET495_RS12260	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
ET495_RS12315	ENOG4108MXC	l-carnitine dehydratase bile acid-inducible protein F
ET495_RS12320	ENOG4105C7E	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity)
ET495_RS12325	ENOG4105CFZ	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity)
ET495_RS12345	ENOG4105D52	delta-aminolevulinic acid dehydratase
ET495_RS12350	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
ET495_RS12355	ENOG4105VPX	protein, conserved in bacteria
ET495_RS12385	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
ET495_RS12400	ENOG4108426	dNA-binding protein
ET495_RS12430	ENOG4105WH1	Two component transcriptional regulator luxr family
ET495_RS12450	ENOG4105CCA	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity)
ET495_RS12515	ENOG4105D22	carbon starvation protein
ET495_RS12535	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
ET495_RS12585	ENOG4105CIK	Amidinotransferase
ET495_RS12600	ENOG41080V3	Major Facilitator superfamily
ET495_RS12620	ENOG4108AZI	Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2- methyl-5-hydroxymethylpyrimidine phosphate (HMP-P) (By similarity)
ET495_RS12630	ENOG4105C1X	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity)
ET495_RS12645	ENOG4105CJW	magnesium transporter
ET495_RS12650	ENOG4105C7K	acetolactate synthase
ET495_RS12745	ENOG4108W5M	transcriptional regulator
ET495_RS12750	ENOG4105CHR	reductase
ET495_RS12760	ENOG4108SC4	)-transporter
ET495_RS12780	ENOG4105CDU	Replicative dna helicase
ET495_RS12785	ENOG4105UQX	Mate efflux family protein
ET495_RS12790	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
ET495_RS12795	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
ET495_RS12805	ENOG410829C	Binds together with S18 to 16S ribosomal RNA (By similarity)
ET495_RS12815	ENOG4105K7K	Transcriptional regulator
ET495_RS12820	ENOG4105CZA	synthase
ET495_RS12920	ENOG41062IR	nudix hydrolase
ET495_RS12945	ENOG4105C3M	thioredoxin reductase
ET495_RS12950	ENOG4105K63	Thioredoxin
ET495_RS12960	ENOG4105CPF	Cell wall formation (By similarity)
ET495_RS12970	ENOG4107QJE	Chromosome Partitioning Protein
ET495_RS12975	ENOG4107XUG	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
ET495_RS12990	ENOG4105VAS	Could be involved in insertion of integral membrane proteins into the membrane (By similarity)
ET495_RS12995	ENOG4105XH8	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
ET495_RS13000	ENOG41084CH	50S ribosomal protein l34
ET495_RS13005	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
ET495_RS13010	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
ET495_RS13015	ENOG4108J5G	6-phosphogluconate dehydrogenase
ET495_RS13025	ENOG4105K7N	UPF0232 protein
ET495_RS13030	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
ET495_RS13035	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
ET495_RS13055	ENOG4105EB3	Histidine kinase
ET495_RS13060	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
ET495_RS13075	ENOG4105CSR	polyphosphate kinase 2
ET495_RS13095	ENOG4105ZJT	Cell division protein CrgA
ET495_RS13105	ENOG4108U4N	(sortase) family
ET495_RS13115	ENOG4105D9P	serine threonine protein kinase
ET495_RS13120	ENOG4107TPY	serine threonine protein kinase
ET495_RS13140	ENOG4105HZM	Fha domain containing protein
ET495_RS13170	ENOG4105WH1	Two component transcriptional regulator luxr family
ET495_RS13195	ENOG4105KJF	protein tyrosine phosphatase
ET495_RS13220	ENOG4105CHM	Aminotransferase
ET495_RS13255	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
ET495_RS13260	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
ET495_RS13290	ENOG4105SYT	Methylenetetrahydrofolate reductase
ET495_RS13300	ENOG4105CEY	Amp-dependent synthetase and ligase
ET495_RS13315	ENOG4108R3E	Dna-3-methyladenine glycosylase i
ET495_RS13340	ENOG4108ZG0	Ompa motb domain protein
ET495_RS13345	ENOG4105CK2	sodium dicarboxylate symporter
ET495_RS13350	ENOG4105CEQ	signal transduction histidine kinase regulating citrate malate metabolism
ET495_RS13355	ENOG4108MRH	transcriptional regulatory protein
ET495_RS13360	ENOG4108UVJ	appr-1-p processing domain protein
ET495_RS13380	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
ET495_RS13410	ENOG4105E5Q	amino acid AbC transporter
ET495_RS13435	ENOG4105VEQ	Cold shock protein
ET495_RS13445	ENOG4108IV0	ABC, transporter
ET495_RS13450	ENOG4105C0Z	ABC transporter
ET495_RS13455	ENOG4105CF8	branched-chain amino acid ABC transporter, permease
ET495_RS13460	ENOG4105C32	Amino acid ABC transporter (Permease)
ET495_RS13480	ENOG4105C5W	Aldolase
ET495_RS13505	ENOG4105K5B	UPF0225 protein
ET495_RS13510	ENOG4105F27	Major Facilitator
ET495_RS13580	ENOG4107RAW	3-carboxy-cis-cis-muconate cycloisomerase
ET495_RS13590	ENOG4108X07	Tetr family transcriptional regulator
ET495_RS13595	ENOG4105CIG	ABC transporter
ET495_RS13630	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
ET495_RS13635	ENOG4108IXY	short-chain dehydrogenase reductase
ET495_RS13645	ENOG4108ZM9	phosphoglycerate mutase
ET495_RS13665	ENOG4105C6Z	Gluconate
ET495_RS13670	ENOG4108Z67	carbohydrate kinase, thermoresistant glucokinase family
ET495_RS13740	ENOG41060M0	Crispr-associated protein, cse4 family
ET495_RS13745	ENOG4108VWQ	crispr-associated protein
ET495_RS13760	ENOG4105D5G	Transposase
ET495_RS13765	ENOG4105D5G	Transposase
ET495_RS13790	ENOG4108VC7	Protein of unknown function (DUF2587)
ET495_RS13795	ENOG4105EE6	Alcohol dehydrogenase zinc-binding domain protein
ET495_RS13805	ENOG4105GWZ	Roadblock lc7 family protein
ET495_RS13875	ENOG4107QP8	phosphohexose isomerase
ET495_RS13885	ENOG4105ETE	Transcriptional regulator (LacI family
ET495_RS13895	ENOG4105F0P	binding-protein-dependent transport systems inner membrane Component
ET495_RS13955	ENOG4105WMM	Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity)
ET495_RS13960	ENOG4107RSS	Hydrogenase accessory protein HypB
ET495_RS13975	ENOG4105WMM	Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity)
ET495_RS13980	ENOG4108USZ	hydrogenase
ET495_RS13985	ENOG4105X7T	Ni Fe-hydrogenase, b-type cytochrome subunit
ET495_RS13990	ENOG4105DPX	Hydrogenase, large subunit
ET495_RS13995	ENOG4105E3S	small subunit
ET495_RS14000	ENOG4108UHE	carbonic anhydrase
ET495_RS14010	ENOG4105CQS	hydrogenase expression formation protein HypD
ET495_RS14040	ENOG4105CHR	reductase
ET495_RS14065	ENOG4105CFG	Acts as a chaperone (By similarity)
ET495_RS14075	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
ET495_RS14080	ENOG4105KNI	merR family transcriptional Regulator
ET495_RS14095	ENOG4105CZ5	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity)
ET495_RS14100	ENOG4108Z6B	deaminase
ET495_RS14110	ENOG4105BZ1	(ABC) transporter
ET495_RS14150	ENOG4106H3A	restriction
ET495_RS14235	ENOG4105ETE	Transcriptional regulator (LacI family
ET495_RS14245	ENOG4108MJN	Glycosyl Transferase
ET495_RS14265	ENOG4105C1G	acyl-Coa dehydrogenase
ET495_RS14285	ENOG4105MC2	DSBA oxidoreductase
ET495_RS14295	ENOG4105C2W	permease
ET495_RS14325	ENOG4105CHR	reductase
ET495_RS14355	ENOG4105D01	(LipO)protein
ET495_RS14360	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
ET495_RS14365	ENOG4108UMI	ABC transporter, permease
ET495_RS14375	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
ET495_RS14390	ENOG4105CNN	ABC, transporter
ET495_RS14395	ENOG4105DFW	ABC transporter
ET495_RS14410	ENOG4105ETE	Transcriptional regulator (LacI family
ET495_RS14425	ENOG4105DRS	transport system, permease
ET495_RS14440	ENOG4105C1B	dTDP-glucose 4-6-dehydratase
ET495_RS14455	ENOG4105D7N	magnesium and cobalt transport protein CorA
ET495_RS14460	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
ET495_RS14485	ENOG4105KAC	Antibiotic biosynthesis monooxygenase
ET495_RS14550	ENOG4105E0X	reductase
ET495_RS14565	ENOG4108T3F	Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes
ET495_RS14590	ENOG4105CUU	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity)
ET495_RS14605	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
ET495_RS14610	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
ET495_RS14660	ENOG4107J5P	Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity)
ET495_RS14675	ENOG4105EAY	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
ET495_RS14705	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
ET495_RS14715	ENOG4108EE5	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
ET495_RS14725	ENOG4107QI6	Cysteine desulfurase
ET495_RS14730	ENOG4105D18	nicotinate-nucleotide pyrophosphorylase
ET495_RS14735	ENOG4108IYU	L-aspartate oxidase
ET495_RS14740	ENOG4105D0I	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity)
ET495_RS14760	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
ET495_RS14790	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
ET495_RS14800	ENOG4108YV4	Universal stress protein
ET495_RS14825	ENOG4105DRS	transport system, permease
ET495_RS14860	ENOG4105C50	Binding-protein-dependent transport systems, inner membrane component
ET495_RS14875	ENOG4105ETE	Transcriptional regulator (LacI family
ET495_RS14910	ENOG41073TP	transcriptional regulator
ET495_RS14920	ENOG4105CPC	Aldo Keto reductase
ET495_RS14925	ENOG4108RVA	ribokinase
ET495_RS14935	ENOG4108UIQ	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity)
ET495_RS14940	ENOG4105CKW	Inner membrane protein yedI
ET495_RS14945	ENOG4105C0M	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity)
ET495_RS14980	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
ET495_RS14985	ENOG4105C6V	Glycerol-3-phosphate dehydrogenase
ET495_RS15005	ENOG4105E59	Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity)
ET495_RS15010	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
ET495_RS15025	ENOG4105ETE	Transcriptional regulator (LacI family
ET495_RS15040	ENOG4105CAC	Catalyzes the conversion of L-arabinose to L-ribulose (By similarity)
ET495_RS15080	ENOG4105C0D	helicase
ET495_RS15085	ENOG4107ZYR	domain protein
ET495_RS15090	ENOG4105CZN	Potassium uptake protein
ET495_RS15095	ENOG4105DGU	Histone deacetylase
ET495_RS15115	ENOG4105FF6	Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity)
ET495_RS15130	ENOG4108RH7	phosphoglycerate mutase
ET495_RS15140	ENOG4107QIV	Cytochrome c biogenesis protein
ET495_RS15150	ENOG4105CRE	cytochrome C
ET495_RS15175	ENOG4108R5T	secreted protein
ET495_RS15210	ENOG4107SIQ	Naphthoate synthase
ET495_RS15215	ENOG4107TCW	O-succinylbenzoate synthase
ET495_RS15220	ENOG4105C4A	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity)
ET495_RS15245	ENOG4107QJQ	Mate efflux family protein
ET495_RS15250	ENOG4105C0D	helicase
ET495_RS15265	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
ET495_RS15270	ENOG4105E4F	Isochorismate synthase
ET495_RS15275	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
ET495_RS15285	ENOG4105WH1	Two component transcriptional regulator luxr family
ET495_RS15295	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
ET495_RS15300	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
ET495_RS15315	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
ET495_RS15325	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
ET495_RS15340	ENOG4108IEH	NADH dehydrogenase subunit g
ET495_RS15350	ENOG4105P3U	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
ET495_RS15355	ENOG41087XN	oxidoreductase
ET495_RS15360	ENOG4105M5H	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
ET495_RS15365	ENOG4105D65	subunit l
ET495_RS15375	ENOG4105CNR	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
ET495_RS15390	ENOG4105F37	PsaA and PsaB bind P700, the primary electron donor of photosystem I (PSI), as well as the electron acceptors A0, A1 and FX. PSI is a plastocyanin cytochrome c6-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn. Oxidized P700 is reduced on the lumenal side of the thylakoid membrane by plastocyanin or cytochrome c6
ET495_RS15405	ENOG4108ZF3	Phosphatase
ET495_RS15445	ENOG4105F37	PsaA and PsaB bind P700, the primary electron donor of photosystem I (PSI), as well as the electron acceptors A0, A1 and FX. PSI is a plastocyanin cytochrome c6-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn. Oxidized P700 is reduced on the lumenal side of the thylakoid membrane by plastocyanin or cytochrome c6
ET495_RS15490	ENOG4105BZU	Histidine kinase
ET495_RS15495	ENOG4105WH1	Two component transcriptional regulator luxr family
ET495_RS15510	ENOG4105F37	PsaA and PsaB bind P700, the primary electron donor of photosystem I (PSI), as well as the electron acceptors A0, A1 and FX. PSI is a plastocyanin cytochrome c6-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn. Oxidized P700 is reduced on the lumenal side of the thylakoid membrane by plastocyanin or cytochrome c6
ET495_RS15540	ENOG4105D0M	Protease HtpX homolog
ET495_RS15555	ENOG410667J	hydrolase
ET495_RS15560	ENOG4108VPT	UPF0234 protein
ET495_RS15580	ENOG4105WDJ	50S ribosomal protein L33
ET495_RS15585	ENOG410900P	UPF0336 protein
ET495_RS15600	ENOG4106UW1	Major Facilitator superfamily
ET495_RS15605	ENOG4107R4N	Cell wall formation (By similarity)
ET495_RS15615	ENOG4105KME	endoribonuclease L-psp
ET495_RS15620	ENOG4105ERH	Fumarylacetoacetate hydrolase
ET495_RS15625	ENOG4105C29	acyl-CoA thioesterase
ET495_RS15660	ENOG4106IPI	cyclase, family
ET495_RS15690	ENOG4105BZU	Histidine kinase
ET495_RS15725	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
ET495_RS15730	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
ET495_RS15750	ENOG4108VZM	50s ribosomal protein L10
ET495_RS15755	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
ET495_RS15760	ENOG4107QIH	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
ET495_RS15770	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
ET495_RS15775	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
ET495_RS15780	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
ET495_RS15785	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
ET495_RS15790	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
ET495_RS15795	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
ET495_RS15800	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
ET495_RS15805	ENOG4105KZR	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
ET495_RS15810	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ET495_RS15815	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
ET495_RS15820	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
ET495_RS15825	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
ET495_RS15830	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
ET495_RS15835	ENOG41082SA	50s ribosomal protein l29
ET495_RS15840	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
ET495_RS15845	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
ET495_RS15850	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
ET495_RS15855	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ET495_RS15860	ENOG41082QR	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
ET495_RS15865	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
ET495_RS15870	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
ET495_RS15880	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
ET495_RS15885	ENOG410849U	50S ribosomal protein L30
ET495_RS15890	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
ET495_RS15895	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
ET495_RS15900	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
ET495_RS15910	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
ET495_RS15915	ENOG41067V7	50S ribosomal protein L36
ET495_RS15920	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ET495_RS15925	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
ET495_RS15930	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
ET495_RS15935	ENOG4108ZT0	50S ribosomal protein l17
ET495_RS15945	ENOG4105DFK	Polyphosphate glucokinase
ET495_RS15950	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
ET495_RS15965	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
ET495_RS15970	ENOG4108UJD	30S ribosomal protein S9
ET495_RS15980	ENOG4108RBJ	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
ET495_RS15995	ENOG4105CS9	pantothenic acid kinase
ET495_RS16000	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
ET495_RS16005	ENOG41082KK	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity)
ET495_RS16010	ENOG4105EQP	Catalyzes the pyrimidine ring opening between N-3 and C- 4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate (By similarity)
ET495_RS16035	ENOG4108V06	Glutathione peroxidase
ET495_RS16040	ENOG4108YBP	pseudouridine synthase
ET495_RS16055	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
ET495_RS16060	ENOG4108097	ATP-binding protein
ET495_RS16070	ENOG41080E2	ribosomal-protein-alanine acetyltransferase
ET495_RS16080	ENOG4108RDT	NADH dehydrogenase NAD(P)H nitroreductase)
ET495_RS16085	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
ET495_RS16105	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
ET495_RS16110	ENOG4105KIU	Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity)
ET495_RS16120	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
ET495_RS16130	ENOG4107QVP	Dehydrogenase
ET495_RS16135	ENOG4105C26	Dehydrogenase
ET495_RS16150	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
ET495_RS16160	ENOG4107QRI	Phosphoketolase
ET495_RS16170	ENOG4105BZ1	(ABC) transporter
ET495_RS16175	ENOG4105BZ1	(ABC) transporter
ET495_RS16180	ENOG4105WX6	Membrane
ET495_RS16185	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
ET495_RS16210	ENOG4105WH1	Two component transcriptional regulator luxr family
ET495_RS16275	ENOG4105EFS	Binding-protein-dependent transport systems, inner membrane component
ET495_RS16280	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
ET495_RS16285	ENOG4105FBW	Monooxygenase
ET495_RS16295	ENOG4105K4P	CoA-binding domain protein
ET495_RS16305	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
ET495_RS16310	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
ET495_RS16350	ENOG4105D9Z	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
ET495_RS16390	ENOG4105DKQ	ROK family
ET495_RS16395	ENOG4105DFW	ABC transporter
ET495_RS16405	ENOG4108HWW	ABC transporter
ET495_RS16415	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
ET495_RS16420	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
ET495_RS16435	ENOG4105CRD	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity)
ET495_RS16450	ENOG4105F44	Two component transcriptional regulator, winged helix family
ET495_RS16455	ENOG4106F60	Histidine kinase
ET495_RS16470	ENOG4105CJW	magnesium transporter
ET495_RS16480	ENOG4107T6F	Xaa-Pro aminopeptidase
ET495_RS16500	ENOG4108YZG	isomerase
ET495_RS16510	ENOG4107QVN	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
ET495_RS16540	ENOG4105CEY	Amp-dependent synthetase and ligase
ET495_RS16580	ENOG4105C1J	atp-dependent rna helicase
ET495_RS16610	ENOG4105E09	nadh pyrophosphatase
ET495_RS16630	ENOG4105WBQ	Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity)
ET495_RS16655	ENOG4105DJZ	UPF0182 protein
ET495_RS16675	ENOG4105CRD	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity)
ET495_RS16680	ENOG4107HQ7	repeat protein
ET495_RS16685	ENOG4105EZV	Transcriptional regulator
ET495_RS16690	ENOG4105ETE	Transcriptional regulator (LacI family
ET495_RS16720	ENOG4105DET	Rhamnulokinase
ET495_RS16735	ENOG4105CT8	Phosphorylase
ET495_RS16740	ENOG4105C0A	alcohol dehydrogenase
ET495_RS16815	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
ET495_RS16820	ENOG4108UMI	ABC transporter, permease
ET495_RS16825	ENOG4105D01	(LipO)protein
ET495_RS16855	ENOG4105CHR	reductase
ET495_RS16860	ENOG4105D50	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate (By similarity)
ET495_RS16920	ENOG4105VFR	signal peptidase
ET495_RS16935	ENOG4105CHU	acetyl-coa acetyltransferase
ET495_RS16945	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
ET495_RS16950	ENOG4108TZA	Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules (By similarity)
ET495_RS16955	ENOG4105DXM	phenylacetic acid degradation protein
ET495_RS16970	ENOG4108ZJI	phenylacetic acid degradation protein
ET495_RS16975	ENOG4105CRS	phenylacetate-CoA oxygenase PaaG subunit
ET495_RS16980	ENOG4105N76	Phenylacetate-CoA oxygenase, subunit
ET495_RS16985	ENOG4105D9S	phenylacetate-CoA oxygenase PaaI subunit
ET495_RS16990	ENOG4108ZA2	phenylacetate-CoA oxygenase PaaJ subunit
ET495_RS16995	ENOG4105CJJ	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity)
ET495_RS17035	ENOG4105F0P	binding-protein-dependent transport systems inner membrane Component
ET495_RS17080	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
ET495_RS17115	ENOG4105E2D	ec 3.2.1.52
ET495_RS17130	ENOG4108RWI	nicotinamidase
ET495_RS17145	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
ET495_RS17150	ENOG4105F8V	Hydrolase, tatD family
ET495_RS17175	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
ET495_RS17180	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
ET495_RS17185	ENOG4105I82	acetyl xylan esterase
ET495_RS17190	ENOG4105C5H	ABC transporter
ET495_RS17195	ENOG4105M4B	Catalyzes the transfer of an acetyl group from acetyl- CoA to the 6'-amino group of aminoglycoside molecules conferring resistance to antibiotics containing the purpurosamine ring (By similarity)
ET495_RS17240	ENOG4105DJ2	Major Facilitator Superfamily
ET495_RS17245	ENOG4105FS7	Transcriptional regulator
ET495_RS17290	ENOG4105E4C	Lytic transglycosylase catalytic
ET495_RS17295	ENOG4107SN7	NLP P60 protein
ET495_RS17365	ENOG4105FA0	parb-like partition protein
ET495_RS17410	ENOG4105MZU	cell filamentation protein
ET495_RS17415	ENOG4108C33	Resolvase