locus-tag	class	description
XCEL_RS00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
XCEL_RS00015	COG0592	DNA-directed DNA polymerase activity
XCEL_RS00020	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
XCEL_RS00025	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
XCEL_RS00030	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
XCEL_RS00035	COG0187	DNA topoisomerase II activity
XCEL_RS00040	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
XCEL_RS00085	COG3764	Sortase (surface protein transpeptidase)
XCEL_RS00105	COG0515	serine threonine protein kinase
XCEL_RS00110	COG0768	penicillin binding
XCEL_RS00125	COG1716	ATPase activity
XCEL_RS00155	COG0577	efflux transmembrane transporter activity
XCEL_RS00155	COG1136	(ABC) transporter
XCEL_RS00180	COG0702	epimerase
XCEL_RS00185	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
XCEL_RS00210	COG0436	Aminotransferase
XCEL_RS00235	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
XCEL_RS00235	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
XCEL_RS00240	COG0404	The glycine cleavage system catalyzes the degradation of glycine
XCEL_RS00245	COG0509	glycine decarboxylation via glycine cleavage system
XCEL_RS00270	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
XCEL_RS00280	COG0318	PFAM AMP-dependent synthetase and ligase
XCEL_RS00280	COG0204	Acyl-transferase
XCEL_RS00290	COG2818	Glycosylase
XCEL_RS00325	COG0366	Alpha amylase catalytic
XCEL_RS00335	COG4209	transmembrane transport
XCEL_RS00340	COG0395	ABC-type sugar transport system, permease component
XCEL_RS00345	COG0583	DNA-binding transcription factor activity
XCEL_RS00360	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
XCEL_RS00370	COG0805	protein transport
XCEL_RS00385	COG1643	Atp-dependent helicase
XCEL_RS00400	COG4585	Histidine kinase
XCEL_RS00410	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
XCEL_RS00420	COG2376	Dihydroxyacetone kinase
XCEL_RS00425	COG1984	allophanate hydrolase subunit 2
XCEL_RS00430	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
XCEL_RS00475	COG1132	(ABC) transporter
XCEL_RS00480	COG2197	response regulator
XCEL_RS00490	COG1131	(ABC) transporter
XCEL_RS00510	COG0765	amino acid transport
XCEL_RS00515	COG1126	abc transporter atp-binding protein
XCEL_RS00525	COG1278	Cold shock
XCEL_RS00555	COG1770	oligopeptidase
XCEL_RS00655	COG2329	Antibiotic biosynthesis monooxygenase
XCEL_RS00665	COG4702	Belongs to the UPF0303 family
XCEL_RS00670	COG0789	Transcriptional regulator
XCEL_RS00690	COG2201	protein-glutamate methylesterase activity
XCEL_RS00715	COG0659	secondary active sulfate transmembrane transporter activity
XCEL_RS00720	COG1309	transcriptional regulator
XCEL_RS00725	COG1131	(ABC) transporter
XCEL_RS00780	COG0406	alpha-ribazole phosphatase activity
XCEL_RS00800	COG0328	RNA-DNA hybrid ribonuclease activity
XCEL_RS00810	COG3265	gluconokinase activity
XCEL_RS00830	COG1053	succinate dehydrogenase
XCEL_RS00860	COG2018	Roadblock/LC7 domain
XCEL_RS00915	COG1176	ABC-type spermidine putrescine transport system, permease component I
XCEL_RS00920	COG3842	ATPase activity
XCEL_RS00935	COG0166	Belongs to the GPI family
XCEL_RS00950	COG1609	Transcriptional regulator
XCEL_RS00955	COG1472	Belongs to the glycosyl hydrolase 3 family
XCEL_RS00980	COG0589	response to stress
XCEL_RS00990	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
XCEL_RS01020	COG0443	Heat shock 70 kDa protein
XCEL_RS01030	COG0484	heat shock protein binding
XCEL_RS01035	COG0789	Transcriptional regulator
XCEL_RS01050	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
XCEL_RS01055	COG0590	tRNA wobble adenosine to inosine editing
XCEL_RS01065	COG1132	(ABC) transporter
XCEL_RS01075	COG2197	response regulator
XCEL_RS01120	COG0438	transferase activity, transferring glycosyl groups
XCEL_RS01135	COG1960	acyl-CoA dehydrogenase activity
XCEL_RS01145	COG3201	nicotinamide mononucleotide transporter
XCEL_RS01150	COG2223	nitrite transmembrane transporter activity
XCEL_RS01155	COG1309	transcriptional regulator
XCEL_RS01160	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
XCEL_RS01180	COG2233	PERMEase
XCEL_RS01210	COG2197	response regulator
XCEL_RS01215	COG3851	Histidine kinase
XCEL_RS01235	COG2197	response regulator
XCEL_RS01270	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
XCEL_RS01275	COG2011	ABC-type metal ion transport system permease component
XCEL_RS01300	COG1940	carbohydrate kinase activity
XCEL_RS01310	COG1172	Belongs to the binding-protein-dependent transport system permease family
XCEL_RS01325	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
XCEL_RS01335	COG0601	transmembrane transport
XCEL_RS01345	COG0444	Belongs to the ABC transporter superfamily
XCEL_RS01350	COG4172	Belongs to the ABC transporter superfamily
XCEL_RS01375	COG0598	Magnesium transport protein CorA
XCEL_RS01380	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
XCEL_RS01425	COG2329	Antibiotic biosynthesis monooxygenase
XCEL_RS01445	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
XCEL_RS01455	COG1733	regulation of RNA biosynthetic process
XCEL_RS01480	COG0513	Belongs to the DEAD box helicase family
XCEL_RS01485	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
XCEL_RS01520	COG0306	phosphate transporter
XCEL_RS01525	COG0406	alpha-ribazole phosphatase activity
XCEL_RS01525	COG0494	nUDIX hydrolase
XCEL_RS01530	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
XCEL_RS01540	COG0251	oxidation-reduction process
XCEL_RS01545	COG0179	Fumarylacetoacetate (FAA) hydrolase
XCEL_RS01550	COG1946	Acyl-CoA thioesterase
XCEL_RS01570	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
XCEL_RS01575	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
XCEL_RS01585	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
XCEL_RS01600	COG0456	acetyltransferase
XCEL_RS01605	COG4804	nuclease activity
XCEL_RS01610	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
XCEL_RS01615	COG1902	pentaerythritol trinitrate reductase activity
XCEL_RS01670	COG1111	helicase
XCEL_RS01670	COG1205	dead DEAH box helicase
XCEL_RS01685	COG1362	aminopeptidase activity
XCEL_RS01700	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
XCEL_RS01705	COG2514	catechol 2,3-dioxygenase activity
XCEL_RS01715	COG2318	DinB family
XCEL_RS01730	COG2890	protein-(glutamine-N5) methyltransferase activity
XCEL_RS01740	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
XCEL_RS01740	COG1754	DNA topoisomerase type I activity
XCEL_RS01745	COG0577	efflux transmembrane transporter activity
XCEL_RS01745	COG1136	(ABC) transporter
XCEL_RS01750	COG1136	(ABC) transporter
XCEL_RS01755	COG1104	cysteine desulfurase activity
XCEL_RS01765	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
XCEL_RS01770	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
XCEL_RS01815	COG0242	peptide deformylase activity
XCEL_RS01855	COG1609	Transcriptional regulator
XCEL_RS01860	COG4209	transmembrane transport
XCEL_RS01865	COG0395	ABC-type sugar transport system, permease component
XCEL_RS01885	COG1609	Transcriptional regulator
XCEL_RS01900	COG2186	Transcriptional regulator
XCEL_RS01910	COG0667	Aldo Keto reductase
XCEL_RS01925	COG1136	(ABC) transporter
XCEL_RS01940	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
XCEL_RS01945	COG2354	Protein conserved in bacteria
XCEL_RS01955	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
XCEL_RS01970	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
XCEL_RS01975	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
XCEL_RS01980	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
XCEL_RS01985	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
XCEL_RS02000	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
XCEL_RS02015	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
XCEL_RS02020	COG1609	Transcriptional regulator
XCEL_RS02030	COG0235	Class ii aldolase
XCEL_RS02035	COG2160	L-arabinose isomerase activity
XCEL_RS02040	COG4213	ABC transporter substrate-binding protein
XCEL_RS02050	COG4214	carbohydrate transport
XCEL_RS02065	COG1175	transmembrane transport
XCEL_RS02070	COG0395	ABC-type sugar transport system, permease component
XCEL_RS02075	COG1653	transport
XCEL_RS02090	COG1131	(ABC) transporter
XCEL_RS02115	COG1879	ABC-type sugar transport system periplasmic component
XCEL_RS02125	COG1172	Belongs to the binding-protein-dependent transport system permease family
XCEL_RS02130	COG1172	Belongs to the binding-protein-dependent transport system permease family
XCEL_RS02135	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
XCEL_RS02140	COG1116	anion transmembrane transporter activity
XCEL_RS02160	COG0569	domain protein
XCEL_RS02165	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
XCEL_RS02170	COG0123	including yeast histone deacetylase and acetoin utilization protein
XCEL_RS02175	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
XCEL_RS02180	COG0667	Aldo Keto reductase
XCEL_RS02185	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
XCEL_RS02190	COG1116	anion transmembrane transporter activity
XCEL_RS02195	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
XCEL_RS02215	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
XCEL_RS02230	COG0406	alpha-ribazole phosphatase activity
XCEL_RS02240	COG0785	Cytochrome C biogenesis protein
XCEL_RS02245	COG1333	cytochrome c biogenesis protein
XCEL_RS02250	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
XCEL_RS02275	COG1470	cell adhesion involved in biofilm formation
XCEL_RS02295	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
XCEL_RS02300	COG4948	Mandelate Racemase Muconate Lactonizing
XCEL_RS02305	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
XCEL_RS02310	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
XCEL_RS02315	COG1309	transcriptional regulator
XCEL_RS02340	COG0534	Mate efflux family protein
XCEL_RS02345	COG1169	isochorismate synthase
XCEL_RS02350	COG2226	methyltransferase
XCEL_RS02355	COG0644	oxidoreductase
XCEL_RS02365	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XCEL_RS02370	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XCEL_RS02375	COG0649	NAD binding
XCEL_RS02385	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
XCEL_RS02390	COG1034	ATP synthesis coupled electron transport
XCEL_RS02395	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
XCEL_RS02400	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XCEL_RS02405	COG0839	Belongs to the complex I subunit 6 family
XCEL_RS02410	COG0713	ATP synthesis coupled electron transport
XCEL_RS02415	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
XCEL_RS02425	COG1007	ATP synthesis coupled electron transport
XCEL_RS02430	COG0142	geranyltranstransferase activity
XCEL_RS02440	COG0714	Associated with various cellular activities
XCEL_RS02480	COG1674	ftsk spoiiie
XCEL_RS02530	COG0501	Belongs to the peptidase M48B family
XCEL_RS02540	COG0561	phosphatase activity
XCEL_RS02545	COG1660	Displays ATPase and GTPase activities
XCEL_RS02555	COG1666	GTP binding
XCEL_RS02635	COG3617	BRO family, N-terminal domain
XCEL_RS02885	COG0305	Participates in initiation and elongation during chromosome replication
XCEL_RS03000	COG0267	Belongs to the bacterial ribosomal protein bL33 family
XCEL_RS03005	COG2030	dehydratase
XCEL_RS03015	COG1609	Transcriptional regulator
XCEL_RS03020	COG0738	Major facilitator superfamily
XCEL_RS03025	COG0812	UDP-N-acetylmuramate dehydrogenase activity
XCEL_RS03035	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
XCEL_RS03040	COG2197	response regulator
XCEL_RS03045	COG4585	Histidine kinase
XCEL_RS03050	COG0842	Transport permease protein
XCEL_RS03065	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
XCEL_RS03075	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
XCEL_RS03080	COG0081	regulation of translation
XCEL_RS03105	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
XCEL_RS03110	COG0222	ribosome binding
XCEL_RS03115	COG0085	RNA polymerase activity
XCEL_RS03120	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
XCEL_RS03125	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
XCEL_RS03130	COG0049	tRNA binding
XCEL_RS03135	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
XCEL_RS03140	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
XCEL_RS03145	COG0051	transcription antitermination factor activity, RNA binding
XCEL_RS03150	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
XCEL_RS03155	COG0088	Forms part of the polypeptide exit tunnel
XCEL_RS03160	COG0089	rRNA binding
XCEL_RS03165	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
XCEL_RS03170	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
XCEL_RS03175	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
XCEL_RS03180	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
XCEL_RS03185	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
XCEL_RS03190	COG0255	Belongs to the universal ribosomal protein uL29 family
XCEL_RS03195	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
XCEL_RS03200	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
XCEL_RS03205	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
XCEL_RS03210	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
XCEL_RS03215	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
XCEL_RS03220	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
XCEL_RS03225	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
XCEL_RS03235	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
XCEL_RS03240	COG1841	ribosomal large subunit assembly
XCEL_RS03245	COG0200	Binds to the 23S rRNA
XCEL_RS03250	COG0201	protein transport
XCEL_RS03255	COG0563	adenylate kinase activity
XCEL_RS03265	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
XCEL_RS03270	COG0257	Belongs to the bacterial ribosomal protein bL36 family
XCEL_RS03275	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
XCEL_RS03280	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
XCEL_RS03285	COG0202	RNA polymerase activity
XCEL_RS03290	COG0203	ribosomal protein L17
XCEL_RS03300	COG1940	carbohydrate kinase activity
XCEL_RS03305	COG0101	tRNA pseudouridine synthase activity
XCEL_RS03320	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
XCEL_RS03325	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
XCEL_RS03335	COG0242	peptide deformylase activity
XCEL_RS03345	COG1072	(Pantothenic acid kinase))
XCEL_RS03350	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
XCEL_RS03355	COG0736	holo-[acyl-carrier-protein] synthase activity
XCEL_RS03360	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
XCEL_RS03370	COG0386	Belongs to the glutathione peroxidase family
XCEL_RS03375	COG0564	pseudouridine synthase activity
XCEL_RS03380	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
XCEL_RS03385	COG0802	atpase or kinase
XCEL_RS03395	COG0456	acetyltransferase
XCEL_RS03405	COG0778	Nitroreductase
XCEL_RS03410	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
XCEL_RS03420	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
XCEL_RS03435	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
XCEL_RS03460	COG0516	GMP reductase activity
XCEL_RS03465	COG1012	belongs to the aldehyde dehydrogenase family
XCEL_RS03475	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
XCEL_RS03500	COG1132	(ABC) transporter
XCEL_RS03505	COG1132	(ABC) transporter
XCEL_RS03515	COG1136	(ABC) transporter
XCEL_RS03515	COG0577	efflux transmembrane transporter activity
XCEL_RS03540	COG0518	GMP synthase (glutamine-hydrolyzing) activity
XCEL_RS03540	COG0519	Catalyzes the synthesis of GMP from XMP
XCEL_RS03565	COG2197	response regulator
XCEL_RS03570	COG1648	precorrin-2 dehydrogenase activity
XCEL_RS03570	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
XCEL_RS03575	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
XCEL_RS03580	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
XCEL_RS03600	COG0175	sulfate reduction
XCEL_RS03605	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
XCEL_RS03610	COG2855	membrane
XCEL_RS03630	COG2746	aminoglycoside 3-N-acetyltransferase activity
XCEL_RS03635	COG0542	response to heat
XCEL_RS03645	COG0045	succinate-CoA ligase (ADP-forming) activity
XCEL_RS03655	COG1464	Belongs to the NlpA lipoprotein family
XCEL_RS03670	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
XCEL_RS03675	COG2011	ABC-type metal ion transport system permease component
XCEL_RS03705	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
XCEL_RS03725	COG0039	L-malate dehydrogenase activity
XCEL_RS03735	COG0640	Transcriptional regulator
XCEL_RS03775	COG4214	carbohydrate transport
XCEL_RS03780	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
XCEL_RS03785	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
XCEL_RS03800	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
XCEL_RS03805	COG2197	response regulator
XCEL_RS03810	COG4585	Histidine kinase
XCEL_RS03815	COG1131	(ABC) transporter
XCEL_RS03840	COG2239	Acts as a magnesium transporter
XCEL_RS03855	COG0006	proline dipeptidase activity
XCEL_RS03865	COG0613	PHP domain protein
XCEL_RS03870	COG2095	MarC family integral membrane protein
XCEL_RS03880	COG0513	Belongs to the DEAD box helicase family
XCEL_RS03930	COG2816	NAD+ diphosphatase activity
XCEL_RS03970	COG3480	Lon protease (S16) C-terminal proteolytic domain
XCEL_RS03975	COG1615	UPF0182 protein
XCEL_RS04085	COG1136	(ABC) transporter
XCEL_RS04090	COG0577	efflux transmembrane transporter activity
XCEL_RS04090	COG1136	(ABC) transporter
XCEL_RS04095	COG1131	(ABC) transporter
XCEL_RS04125	COG0739	heme binding
XCEL_RS04160	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
XCEL_RS04265	COG1136	(ABC) transporter
XCEL_RS04325	COG1136	(ABC) transporter
XCEL_RS04385	COG3012	SEC-C Motif Domain Protein
XCEL_RS04390	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
XCEL_RS04395	COG2720	vancomycin resistance protein
XCEL_RS04405	COG1129	ABC transporter
XCEL_RS04410	COG1172	Belongs to the binding-protein-dependent transport system permease family
XCEL_RS04415	COG1172	Belongs to the binding-protein-dependent transport system permease family
XCEL_RS04420	COG1879	ABC-type sugar transport system periplasmic component
XCEL_RS04435	COG1028	Short-chain dehydrogenase reductase Sdr
XCEL_RS04435	COG3347	Dehydrogenase
XCEL_RS04440	COG1609	Transcriptional regulator
XCEL_RS04445	COG1556	Lactate utilization protein
XCEL_RS04450	COG1139	Iron-sulfur cluster binding protein
XCEL_RS04455	COG0247	lactate metabolic process
XCEL_RS04480	COG0673	inositol 2-dehydrogenase activity
XCEL_RS04490	COG1175	transmembrane transport
XCEL_RS04495	COG0395	ABC-type sugar transport system, permease component
XCEL_RS04540	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
XCEL_RS04565	COG1012	belongs to the aldehyde dehydrogenase family
XCEL_RS04580	COG1609	Transcriptional regulator
XCEL_RS04600	COG3250	beta-galactosidase activity
XCEL_RS04610	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
XCEL_RS04625	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
XCEL_RS04635	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
XCEL_RS04640	COG1472	Belongs to the glycosyl hydrolase 3 family
XCEL_RS04645	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
XCEL_RS04650	COG0601	transmembrane transport
XCEL_RS04660	COG0444	Belongs to the ABC transporter superfamily
XCEL_RS04675	COG0114	fumarate hydratase activity
XCEL_RS04685	COG1722	exodeoxyribonuclease VII activity
XCEL_RS04690	COG0488	(ABC) transporter
XCEL_RS04695	COG1570	exodeoxyribonuclease VII activity
XCEL_RS04710	COG1322	Protein conserved in bacteria
XCEL_RS04730	COG0012	GTP binding
XCEL_RS04755	COG4166	transmembrane transport
XCEL_RS04760	COG0601	transmembrane transport
XCEL_RS04765	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
XCEL_RS04770	COG0444	Belongs to the ABC transporter superfamily
XCEL_RS04775	COG4608	Belongs to the ABC transporter superfamily
XCEL_RS04800	COG4172	Belongs to the ABC transporter superfamily
XCEL_RS04805	COG1217	gtp-binding protein TYPA
XCEL_RS04810	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
XCEL_RS04830	COG0077	Prephenate dehydratase
XCEL_RS04835	COG0287	Prephenate dehydrogenase
XCEL_RS04875	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
XCEL_RS04880	COG1611	Belongs to the LOG family
XCEL_RS04885	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
XCEL_RS04900	COG1595	DNA-templated transcription, initiation
XCEL_RS04915	COG0180	Tryptophanyl-tRNA synthetase
XCEL_RS04930	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
XCEL_RS04935	COG1053	succinate dehydrogenase
XCEL_RS04945	COG2009	succinate dehydrogenase
XCEL_RS04950	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
XCEL_RS04950	COG0662	Cupin 2, conserved barrel domain protein
XCEL_RS04955	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
XCEL_RS04955	COG1473	amidohydrolase
XCEL_RS04960	COG1744	ABC transporter substrate-binding protein PnrA-like
XCEL_RS04965	COG3845	ABC transporter
XCEL_RS04970	COG4603	Belongs to the binding-protein-dependent transport system permease family
XCEL_RS04975	COG1079	Belongs to the binding-protein-dependent transport system permease family
XCEL_RS05000	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
XCEL_RS05005	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
XCEL_RS05015	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
XCEL_RS05035	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
XCEL_RS05050	COG4770	biotin carboxylase activity
XCEL_RS05055	COG0424	maF-like protein
XCEL_RS05095	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
XCEL_RS05110	COG2135	peptidase activity
XCEL_RS05115	COG1316	TRANSCRIPTIONal
XCEL_RS05120	COG1316	TRANSCRIPTIONal
XCEL_RS05160	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
XCEL_RS05165	COG2884	Cell division ATP-binding protein ftsE
XCEL_RS05170	COG2177	Part of the ABC transporter FtsEX involved in
XCEL_RS05180	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
XCEL_RS05190	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
XCEL_RS05210	COG1846	Transcriptional regulator
XCEL_RS05210	COG1940	carbohydrate kinase activity
XCEL_RS05220	COG1175	transmembrane transport
XCEL_RS05225	COG0395	ABC-type sugar transport system, permease component
XCEL_RS05235	COG0363	glucosamine-6-phosphate deaminase activity
XCEL_RS05260	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
XCEL_RS05270	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
XCEL_RS05280	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
XCEL_RS05285	COG1234	tRNA 3'-trailer cleavage
XCEL_RS05295	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
XCEL_RS05300	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
XCEL_RS05305	COG0488	(ABC) transporter
XCEL_RS05315	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
XCEL_RS05320	COG2154	pterin-4-alpha-carbinolamine dehydratase
XCEL_RS05370	COG0220	tRNA (guanine-N7-)-methyltransferase activity
XCEL_RS05380	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
XCEL_RS05400	COG1174	glycine betaine transport
XCEL_RS05405	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
XCEL_RS05425	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
XCEL_RS05445	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
XCEL_RS05470	COG0481	GTPase activity
XCEL_RS05510	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
XCEL_RS05515	COG0668	transmembrane transport
XCEL_RS05535	COG3590	peptidase
XCEL_RS05555	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
XCEL_RS05565	COG1045	serine acetyltransferase
XCEL_RS05615	COG0544	peptidyl-prolyl cis-trans isomerase activity
XCEL_RS05625	COG0740	serine-type endopeptidase activity
XCEL_RS05630	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
XCEL_RS05640	COG1605	Chorismate mutase
XCEL_RS05640	COG0287	Prephenate dehydrogenase
XCEL_RS05655	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
XCEL_RS05660	COG0765	amino acid transport
XCEL_RS05665	COG1126	abc transporter atp-binding protein
XCEL_RS05675	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
XCEL_RS05680	COG0778	Nitroreductase
XCEL_RS05680	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
XCEL_RS05700	COG1252	NADH dehydrogenase
XCEL_RS05705	COG1595	DNA-templated transcription, initiation
XCEL_RS05725	COG0395	ABC-type sugar transport system, permease component
XCEL_RS05765	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
XCEL_RS05770	COG0285	dihydrofolate synthase activity
XCEL_RS05775	COG5297	Belongs to the glycosyl hydrolase family 6
XCEL_RS05780	COG1609	Transcriptional regulator
XCEL_RS05790	COG5297	Belongs to the glycosyl hydrolase family 6
XCEL_RS05790	COG4733	cellulase activity
XCEL_RS05795	COG2376	Dihydroxyacetone kinase
XCEL_RS05800	COG1461	Dihydroxyacetone kinase
XCEL_RS05815	COG0105	UTP biosynthetic process
XCEL_RS05820	COG1196	nuclear chromosome segregation
XCEL_RS05845	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
XCEL_RS05860	COG0228	four-way junction DNA binding
XCEL_RS05865	COG1837	Belongs to the UPF0109 family
XCEL_RS05870	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
XCEL_RS05875	COG0336	Belongs to the RNA methyltransferase TrmD family
XCEL_RS05880	COG0335	large ribosomal subunit rRNA binding
XCEL_RS05885	COG0681	Belongs to the peptidase S26 family
XCEL_RS05890	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
XCEL_RS05900	COG0792	nuclease activity
XCEL_RS05915	COG4974	Belongs to the 'phage' integrase family
XCEL_RS05925	COG0052	Belongs to the universal ribosomal protein uS2 family
XCEL_RS05930	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
XCEL_RS05940	COG0233	cytoplasmic translational termination
XCEL_RS05945	COG0575	Belongs to the CDS family
XCEL_RS05950	COG0820	rRNA (adenine-C2-)-methyltransferase activity
XCEL_RS05970	COG0395	ABC-type sugar transport system, permease component
XCEL_RS05995	COG1501	Belongs to the glycosyl hydrolase 31 family
XCEL_RS06000	COG1472	Belongs to the glycosyl hydrolase 3 family
XCEL_RS06025	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
XCEL_RS06030	COG0750	zinc metalloprotease
XCEL_RS06035	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
XCEL_RS06050	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
XCEL_RS06055	COG0442	prolyl-tRNA aminoacylation
XCEL_RS06065	COG0779	Required for maturation of 30S ribosomal subunits
XCEL_RS06080	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
XCEL_RS06085	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
XCEL_RS06090	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
XCEL_RS06110	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
XCEL_RS06115	COG1185	polyribonucleotide nucleotidyltransferase activity
XCEL_RS06120	COG0612	Peptidase, M16
XCEL_RS06125	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
XCEL_RS06180	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
XCEL_RS06200	COG1674	ftsk spoiiie
XCEL_RS06215	COG1546	Belongs to the CinA family
XCEL_RS06215	COG1058	Belongs to the CinA family
XCEL_RS06220	COG1396	sequence-specific DNA binding
XCEL_RS06225	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
XCEL_RS06230	COG1201	RNA secondary structure unwinding
XCEL_RS06240	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
XCEL_RS06245	COG2137	regulation of response to DNA damage stimulus
XCEL_RS06250	COG0765	amino acid transport
XCEL_RS06255	COG0765	amino acid transport
XCEL_RS06260	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
XCEL_RS06265	COG1126	abc transporter atp-binding protein
XCEL_RS06270	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
XCEL_RS06290	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
XCEL_RS06295	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
XCEL_RS06300	COG2813	Specifically methylates the guanine in position
XCEL_RS06305	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
XCEL_RS06320	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
XCEL_RS06325	COG1388	LysM domain
XCEL_RS06330	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
XCEL_RS06335	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
XCEL_RS06350	COG4251	negative regulation of phosphorylation
XCEL_RS06355	COG0784	Response regulator, receiver
XCEL_RS06365	COG1278	Cold shock
XCEL_RS06380	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
XCEL_RS06400	COG0714	Associated with various cellular activities
XCEL_RS06405	COG2001	Belongs to the MraZ family
XCEL_RS06410	COG0275	rRNA processing
XCEL_RS06420	COG0768	penicillin binding
XCEL_RS06435	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
XCEL_RS06440	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
XCEL_RS06450	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
XCEL_RS06455	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
XCEL_RS06465	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
XCEL_RS06475	COG1799	cell septum assembly
XCEL_RS06485	COG3599	regulation of cell shape
XCEL_RS06495	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
XCEL_RS06510	COG0587	DNA-directed DNA polymerase activity
XCEL_RS06535	COG2501	S4 domain
XCEL_RS06540	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
XCEL_RS06545	COG1660	Displays ATPase and GTPase activities
XCEL_RS06565	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
XCEL_RS06570	COG0131	Imidazoleglycerol-phosphate dehydratase
XCEL_RS06580	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
XCEL_RS06585	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
XCEL_RS06610	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
XCEL_RS06615	COG0291	Belongs to the bacterial ribosomal protein bL35 family
XCEL_RS06620	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
XCEL_RS06625	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
XCEL_RS06635	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
XCEL_RS06665	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
XCEL_RS06670	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
XCEL_RS06675	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
XCEL_RS06680	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
XCEL_RS06690	COG1438	arginine binding
XCEL_RS06695	COG0165	Argininosuccinate lyase
XCEL_RS06700	COG0572	uridine kinase
XCEL_RS06705	COG2094	Belongs to the DNA glycosylase MPG family
XCEL_RS06710	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
XCEL_RS06735	COG0647	UMP catabolic process
XCEL_RS06755	COG0497	DNA recombination
XCEL_RS06780	COG0504	CTP synthase activity
XCEL_RS06785	COG0494	nUDIX hydrolase
XCEL_RS06810	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
XCEL_RS06820	COG1131	(ABC) transporter
XCEL_RS06835	COG0719	Fe-S assembly protein
XCEL_RS06845	COG0396	ATPase activity
XCEL_RS06855	COG0822	iron-sulfur transferase activity
XCEL_RS06860	COG2151	metal-sulfur cluster biosynthetic enzyme
XCEL_RS06885	COG3833	ABC-type maltose transport systems, permease component
XCEL_RS06890	COG1175	transmembrane transport
XCEL_RS06905	COG0673	inositol 2-dehydrogenase activity
XCEL_RS06955	COG2267	carboxylic ester hydrolase activity
XCEL_RS07000	COG4607	ABC-type enterochelin transport system periplasmic component
XCEL_RS07005	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
XCEL_RS07010	COG4605	iron ion homeostasis
XCEL_RS07015	COG4604	ABC transporter, ATP-binding protein
XCEL_RS07025	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
XCEL_RS07030	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
XCEL_RS07045	COG1028	Short-chain dehydrogenase reductase Sdr
XCEL_RS07065	COG1695	Transcriptional regulator
XCEL_RS07080	COG0488	(ABC) transporter
XCEL_RS07105	COG1028	Short-chain dehydrogenase reductase Sdr
XCEL_RS07130	COG0297	glycogen (starch) synthase activity
XCEL_RS07145	COG0745	RESPONSE REGULATOR receiver
XCEL_RS07150	COG2205	protein histidine kinase activity
XCEL_RS07160	COG1119	ATPase activity
XCEL_RS07230	COG0587	DNA-directed DNA polymerase activity
XCEL_RS07250	COG1988	membrane-bound metal-dependent
XCEL_RS07260	COG2382	esterase
XCEL_RS07265	COG1120	ATPase activity
XCEL_RS07270	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
XCEL_RS07275	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
XCEL_RS07280	COG4592	Periplasmic binding protein
XCEL_RS07290	COG0352	thiamine-phosphate diphosphorylase activity
XCEL_RS07290	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
XCEL_RS07290	COG0351	phosphomethylpyrimidine kinase
XCEL_RS07300	COG0352	thiamine-phosphate diphosphorylase activity
XCEL_RS07305	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XCEL_RS07305	COG2022	thiamine diphosphate biosynthetic process
XCEL_RS07315	COG2022	thiamine diphosphate biosynthetic process
XCEL_RS07325	COG2197	response regulator
XCEL_RS07380	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
XCEL_RS07385	COG0488	(ABC) transporter
XCEL_RS07395	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
XCEL_RS07410	COG0656	L-ascorbic acid biosynthetic process
XCEL_RS07420	COG0215	cysteine-tRNA ligase activity
XCEL_RS07430	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
XCEL_RS07440	COG1994	Peptidase M50
XCEL_RS07440	COG0517	IMP dehydrogenase activity
XCEL_RS07450	COG1222	aaa ATPase
XCEL_RS07455	COG4122	O-methyltransferase activity
XCEL_RS07465	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
XCEL_RS07470	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
XCEL_RS07475	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
XCEL_RS07485	COG0107	imidazoleglycerol-phosphate synthase activity
XCEL_RS07490	COG1132	(ABC) transporter
XCEL_RS07495	COG1132	(ABC) transporter
XCEL_RS07520	COG0134	indole-3-glycerol-phosphate synthase activity
XCEL_RS07525	COG0133	tryptophan synthase activity
XCEL_RS07530	COG0159	tryptophan synthase activity
XCEL_RS07535	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
XCEL_RS07540	COG0069	glutamate synthase activity
XCEL_RS07540	COG0070	glutamate synthase
XCEL_RS07540	COG0067	glutamate synthase
XCEL_RS07605	COG0539	negative regulation of cytoplasmic translation
XCEL_RS07610	COG1090	epimerase
XCEL_RS07630	COG0237	dephospho-CoA kinase activity
XCEL_RS07630	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
XCEL_RS07670	COG0556	nucleotide-excision repair
XCEL_RS07750	COG0322	excinuclease ABC activity
XCEL_RS07755	COG1660	Displays ATPase and GTPase activities
XCEL_RS07760	COG0391	Required for morphogenesis under gluconeogenic growth conditions
XCEL_RS07765	COG1481	regulation of sporulation
XCEL_RS07770	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
XCEL_RS07775	COG0126	phosphoglycerate kinase activity
XCEL_RS07780	COG0149	triose-phosphate isomerase activity
XCEL_RS07785	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
XCEL_RS07795	COG0363	glucosamine-6-phosphate deaminase activity
XCEL_RS07810	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
XCEL_RS07820	COG0109	protoheme IX farnesyltransferase activity
XCEL_RS07840	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
XCEL_RS07845	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
XCEL_RS07855	COG1160	GTP binding
XCEL_RS07930	COG4974	Belongs to the 'phage' integrase family
XCEL_RS07955	COG1136	(ABC) transporter
XCEL_RS08065	COG2226	methyltransferase
XCEL_RS08075	COG3012	SEC-C Motif Domain Protein
XCEL_RS08115	COG1136	(ABC) transporter
XCEL_RS08115	COG0577	efflux transmembrane transporter activity
XCEL_RS08120	COG4585	Histidine kinase
XCEL_RS08125	COG2197	response regulator
XCEL_RS08130	COG2197	response regulator
XCEL_RS08135	COG4585	Histidine kinase
XCEL_RS08155	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
XCEL_RS08160	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
XCEL_RS08160	COG2146	nitrite reductase [NAD(P)H] activity
XCEL_RS08165	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
XCEL_RS08165	COG1648	precorrin-2 dehydrogenase activity
XCEL_RS08170	COG4122	O-methyltransferase activity
XCEL_RS08175	COG2267	carboxylic ester hydrolase activity
XCEL_RS08190	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
XCEL_RS08195	COG1309	transcriptional regulator
XCEL_RS08200	COG2197	response regulator
XCEL_RS08205	COG4585	Histidine kinase
XCEL_RS08260	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
XCEL_RS08265	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
XCEL_RS08275	COG0673	inositol 2-dehydrogenase activity
XCEL_RS08285	COG2318	DinB family
XCEL_RS08315	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
XCEL_RS08325	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
XCEL_RS08330	COG1560	Kdo2-lipid A biosynthetic process
XCEL_RS08335	COG0438	transferase activity, transferring glycosyl groups
XCEL_RS08345	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
XCEL_RS08350	COG1051	belongs to the nudix hydrolase family
XCEL_RS08355	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
XCEL_RS08360	COG0217	transcriptional regulatory protein
XCEL_RS08365	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
XCEL_RS08370	COG0632	four-way junction helicase activity
XCEL_RS08375	COG2255	four-way junction helicase activity
XCEL_RS08385	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
XCEL_RS08390	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
XCEL_RS08395	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
XCEL_RS08400	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
XCEL_RS08405	COG1793	dna ligase
XCEL_RS08420	COG1196	nuclear chromosome segregation
XCEL_RS08430	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
XCEL_RS08435	COG0124	histidyl-tRNA synthetase
XCEL_RS08445	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
XCEL_RS08465	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
XCEL_RS08480	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
XCEL_RS08485	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
XCEL_RS08500	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
XCEL_RS08505	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
XCEL_RS08510	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
XCEL_RS08515	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
XCEL_RS08515	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
XCEL_RS08545	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
XCEL_RS08560	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
XCEL_RS08565	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
XCEL_RS08570	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
XCEL_RS08575	COG0540	Belongs to the ATCase OTCase family
XCEL_RS08580	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
XCEL_RS08595	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
XCEL_RS08600	COG0284	orotidine-5'-phosphate decarboxylase activity
XCEL_RS08605	COG0322	excinuclease ABC activity
XCEL_RS08615	COG1758	RNA polymerase activity
XCEL_RS08625	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
XCEL_RS08645	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
XCEL_RS08660	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
XCEL_RS08675	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
XCEL_RS08675	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
XCEL_RS08680	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
XCEL_RS08685	COG0140	phosphoribosyl-ATP diphosphatase activity
XCEL_RS08690	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
XCEL_RS08725	COG1716	ATPase activity
XCEL_RS08745	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
XCEL_RS08780	COG3340	Belongs to the peptidase S51 family
XCEL_RS08790	COG2337	Toxic component of a toxin-antitoxin (TA) module
XCEL_RS08815	COG3550	peptidyl-serine autophosphorylation
XCEL_RS08860	COG1487	ribonuclease activity
XCEL_RS08870	COG0137	argininosuccinate synthase activity
XCEL_RS08890	COG0686	Belongs to the AlaDH PNT family
XCEL_RS08900	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
XCEL_RS08910	COG0815	Transfers the fatty acyl group on membrane lipoproteins
XCEL_RS08915	COG1228	amidohydrolase
XCEL_RS08925	COG1597	lipid kinase activity
XCEL_RS08930	COG0805	protein transport
XCEL_RS08950	COG2378	regulation of single-species biofilm formation
XCEL_RS08970	COG0714	Associated with various cellular activities
XCEL_RS08990	COG0783	Belongs to the Dps family
XCEL_RS09000	COG1739	Uncharacterized protein family UPF0029
XCEL_RS09010	COG0009	L-threonylcarbamoyladenylate synthase
XCEL_RS09045	COG3486	L-lysine 6-monooxygenase (NADPH) activity
XCEL_RS09060	COG1132	(ABC) transporter
XCEL_RS09065	COG1132	(ABC) transporter
XCEL_RS09100	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
XCEL_RS09100	COG2146	nitrite reductase [NAD(P)H] activity
XCEL_RS09105	COG2146	nitrite reductase [NAD(P)H] activity
XCEL_RS09105	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
XCEL_RS09120	COG0315	cyclic pyranopterin monophosphate synthase activity
XCEL_RS09135	COG0243	molybdopterin cofactor binding
XCEL_RS09140	COG2223	nitrite transmembrane transporter activity
XCEL_RS09155	COG1140	nitrate reductase beta subunit
XCEL_RS09225	COG0475	glutathione-regulated potassium exporter activity
XCEL_RS09230	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
XCEL_RS09235	COG1006	Multisubunit Na H antiporter MnhC subunit
XCEL_RS09260	COG2111	Na H antiporter
XCEL_RS09260	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
XCEL_RS09265	COG4608	Belongs to the ABC transporter superfamily
XCEL_RS09270	COG0444	Belongs to the ABC transporter superfamily
XCEL_RS09275	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
XCEL_RS09280	COG0601	transmembrane transport
XCEL_RS09285	COG4166	transmembrane transport
XCEL_RS09310	COG1022	Amp-dependent synthetase and ligase
XCEL_RS09320	COG1253	flavin adenine dinucleotide binding
XCEL_RS09335	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
XCEL_RS09340	COG2116	formate transmembrane transporter activity
XCEL_RS09345	COG4269	membrane
XCEL_RS09360	COG0640	Transcriptional regulator
XCEL_RS09470	COG2326	polyphosphate kinase activity
XCEL_RS09475	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
XCEL_RS09505	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
XCEL_RS09515	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
XCEL_RS09520	COG0183	Belongs to the thiolase family
XCEL_RS09525	COG1250	3-hydroxyacyl-CoA dehydrogenase
XCEL_RS09525	COG1024	Enoyl-CoA hydratase
XCEL_RS09530	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
XCEL_RS09540	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
XCEL_RS09560	COG3973	AAA domain
XCEL_RS09565	COG0494	nUDIX hydrolase
XCEL_RS09575	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
XCEL_RS09590	COG1131	(ABC) transporter
XCEL_RS09605	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
XCEL_RS09640	COG0531	amino acid
XCEL_RS09645	COG0569	domain protein
XCEL_RS09670	COG0756	dUTP diphosphatase activity
XCEL_RS09690	COG2860	membrane
XCEL_RS09705	COG1435	thymidine kinase activity
XCEL_RS09730	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
XCEL_RS09760	COG1410	methionine synthase
XCEL_RS09760	COG0646	methionine synthase
XCEL_RS09900	COG1132	(ABC) transporter
XCEL_RS09905	COG0446	pyridine nucleotide-disulphide oxidoreductase
XCEL_RS09910	COG1937	Protein conserved in bacteria
XCEL_RS09920	COG0318	PFAM AMP-dependent synthetase and ligase
XCEL_RS09950	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
XCEL_RS09965	COG3655	Transcriptional regulator
XCEL_RS09975	COG4941	Belongs to the sigma-70 factor family
XCEL_RS09995	COG0187	DNA topoisomerase II activity
XCEL_RS10010	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
XCEL_RS10015	COG0589	response to stress
XCEL_RS10030	COG0142	geranyltranstransferase activity
XCEL_RS10040	COG0515	serine threonine protein kinase
XCEL_RS10040	COG2815	serine threonine protein kinase
XCEL_RS10045	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
XCEL_RS10065	COG1940	carbohydrate kinase activity
XCEL_RS10085	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
XCEL_RS10095	COG1845	cytochrome c oxidase, subunit III
XCEL_RS10100	COG2010	Cytochrome c
XCEL_RS10105	COG0723	plastoquinol--plastocyanin reductase activity
XCEL_RS10110	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
XCEL_RS10130	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
XCEL_RS10135	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
XCEL_RS10170	COG0667	Aldo Keto reductase
XCEL_RS10185	COG0167	dihydroorotate dehydrogenase activity
XCEL_RS10200	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
XCEL_RS10205	COG0508	dehydrogenase complex catalyzes the overall conversion of
XCEL_RS10220	COG0673	inositol 2-dehydrogenase activity
XCEL_RS10225	COG0321	lipoyl(octanoyl) transferase activity
XCEL_RS10230	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
XCEL_RS10265	COG0596	Alpha beta hydrolase
XCEL_RS10270	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
XCEL_RS10285	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
XCEL_RS10290	COG0174	glutamine synthetase
XCEL_RS10310	COG0530	calcium, potassium:sodium antiporter activity
XCEL_RS10460	COG3022	response to hydroperoxide
XCEL_RS10475	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
XCEL_RS10480	COG0659	secondary active sulfate transmembrane transporter activity
XCEL_RS10500	COG0514	ATP-dependent DNA helicase (RecQ)
XCEL_RS10520	COG0442	prolyl-tRNA aminoacylation
XCEL_RS10540	COG0022	dehydrogenase e1 component
XCEL_RS10545	COG0508	dehydrogenase complex catalyzes the overall conversion of
XCEL_RS10550	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
XCEL_RS10560	COG1960	acyl-CoA dehydrogenase activity
XCEL_RS10575	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
XCEL_RS10585	COG0183	Belongs to the thiolase family
XCEL_RS10605	COG0477	Major facilitator Superfamily
XCEL_RS10625	COG1175	transmembrane transport
XCEL_RS10630	COG0395	ABC-type sugar transport system, permease component
XCEL_RS10645	COG0366	Alpha amylase catalytic
XCEL_RS10655	COG1940	carbohydrate kinase activity
XCEL_RS10660	COG2188	Transcriptional regulator
XCEL_RS10665	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
XCEL_RS10720	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
XCEL_RS10740	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
XCEL_RS10745	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
XCEL_RS10750	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
XCEL_RS10805	COG1522	sequence-specific DNA binding
XCEL_RS10815	COG2814	Major facilitator Superfamily
XCEL_RS10825	COG2182	Extracellular solute-binding protein
XCEL_RS10830	COG1175	transmembrane transport
XCEL_RS10835	COG3833	ABC-type maltose transport systems, permease component
XCEL_RS10855	COG0366	Alpha amylase catalytic
XCEL_RS10860	COG0366	Alpha amylase catalytic
XCEL_RS10865	COG3833	ABC-type maltose transport systems, permease component
XCEL_RS10870	COG1175	transmembrane transport
XCEL_RS10885	COG0366	Alpha amylase catalytic
XCEL_RS10900	COG0423	glycine-tRNA ligase activity
XCEL_RS10905	COG0803	Belongs to the bacterial solute-binding protein 9 family
XCEL_RS10905	COG3443	Belongs to the bacterial solute-binding protein 9 family
XCEL_RS10910	COG1121	(ABC) transporter
XCEL_RS10915	COG1108	ABC-type Mn2 Zn2 transport systems permease components
XCEL_RS10925	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
XCEL_RS10930	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
XCEL_RS10935	COG1120	ATPase activity
XCEL_RS10945	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
XCEL_RS10950	COG1381	Involved in DNA repair and RecF pathway recombination
XCEL_RS10955	COG0740	serine-type endopeptidase activity
XCEL_RS10960	COG0740	serine-type endopeptidase activity
XCEL_RS10965	COG1396	sequence-specific DNA binding
XCEL_RS10975	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
XCEL_RS10990	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
XCEL_RS11000	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
XCEL_RS11010	COG0537	adenosine 5'-monophosphoramidase activity
XCEL_RS11020	COG0484	heat shock protein binding
XCEL_RS11025	COG1420	regulation of RNA biosynthetic process
XCEL_RS11035	COG1672	PFAM Archaeal ATPase
XCEL_RS11035	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
XCEL_RS11060	COG0481	GTPase activity
XCEL_RS11075	COG1305	Transglutaminase-like
XCEL_RS11095	COG0268	Binds directly to 16S ribosomal RNA
XCEL_RS11140	COG1307	EDD domain protein, DegV family
XCEL_RS11145	COG0433	COG0433 Predicted ATPase
XCEL_RS11150	COG4552	Acetyltransferase involved in intracellular survival and related
XCEL_RS11155	COG0058	SHG alpha-glucan phosphorylase activity
XCEL_RS11185	COG2814	Major facilitator Superfamily
XCEL_RS11205	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
XCEL_RS11220	COG2357	RelA SpoT domain protein
XCEL_RS11230	COG4941	Belongs to the sigma-70 factor family
XCEL_RS11235	COG3795	YCII-related domain
XCEL_RS11265	COG0579	oxidoreductase
XCEL_RS11270	COG0583	DNA-binding transcription factor activity
XCEL_RS11285	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
XCEL_RS11290	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
XCEL_RS11315	COG0588	phosphoglycerate mutase activity
XCEL_RS11320	COG0799	negative regulation of ribosome biogenesis
XCEL_RS11330	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
XCEL_RS11335	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
XCEL_RS11340	COG0477	Major facilitator Superfamily
XCEL_RS11345	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
XCEL_RS11355	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
XCEL_RS11360	COG0211	Belongs to the bacterial ribosomal protein bL27 family
XCEL_RS11365	COG0261	This protein binds to 23S rRNA in the presence of protein L20
XCEL_RS11370	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
XCEL_RS11380	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
XCEL_RS11390	COG1435	thymidine kinase activity
XCEL_RS11395	COG1530	ribonuclease E activity
XCEL_RS11400	COG1271	oxidase subunit
XCEL_RS11405	COG1294	oxidase, subunit
XCEL_RS11410	COG4988	ABC transporter
XCEL_RS11415	COG1132	(ABC) transporter
XCEL_RS11425	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
XCEL_RS11430	COG0571	ribonuclease III activity
XCEL_RS11435	COG0333	Belongs to the bacterial ribosomal protein bL32 family
XCEL_RS11455	COG0742	ribosomal rna small subunit methyltransferase
XCEL_RS11465	COG1461	Dihydroxyacetone kinase
XCEL_RS11470	COG0227	Belongs to the bacterial ribosomal protein bL28 family
XCEL_RS11490	COG1181	Belongs to the D-alanine--D-alanine ligase family
XCEL_RS11500	COG0009	L-threonylcarbamoyladenylate synthase
XCEL_RS11505	COG2271	Major facilitator Superfamily
XCEL_RS11510	COG4977	sequence-specific DNA binding
XCEL_RS11525	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
XCEL_RS11535	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
XCEL_RS11540	COG0477	Major facilitator Superfamily
XCEL_RS11545	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
XCEL_RS11560	COG0602	queuosine metabolic process
XCEL_RS11565	COG1328	CTP reductase activity
XCEL_RS11575	COG2149	membrane
XCEL_RS11595	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
XCEL_RS11600	COG1120	ATPase activity
XCEL_RS11620	COG1733	regulation of RNA biosynthetic process
XCEL_RS11625	COG2337	Toxic component of a toxin-antitoxin (TA) module
XCEL_RS11685	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
XCEL_RS11690	COG0210	DNA helicase
XCEL_RS11755	COG1619	proteins homologs of microcin C7 resistance protein MccF
XCEL_RS11820	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
XCEL_RS11835	COG0066	3-isopropylmalate dehydratase activity
XCEL_RS11840	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
XCEL_RS11845	COG1414	Transcriptional regulator
XCEL_RS11880	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
XCEL_RS11895	COG0179	Fumarylacetoacetate (FAA) hydrolase
XCEL_RS11950	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
XCEL_RS11955	COG3304	Inner membrane component domain
XCEL_RS11975	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
XCEL_RS11980	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
XCEL_RS11985	COG0473	3-isopropylmalate dehydrogenase activity
XCEL_RS11990	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
XCEL_RS11995	COG0440	acetolactate synthase activity
XCEL_RS12005	COG2154	pterin-4-alpha-carbinolamine dehydratase
XCEL_RS12015	COG0129	dihydroxy-acid dehydratase activity
XCEL_RS12020	COG0129	dihydroxy-acid dehydratase activity
XCEL_RS12030	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
XCEL_RS12035	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
XCEL_RS12040	COG0154	amidase activity
XCEL_RS12045	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
XCEL_RS12080	COG1879	ABC-type sugar transport system periplasmic component
XCEL_RS12085	COG1172	Belongs to the binding-protein-dependent transport system permease family
XCEL_RS12090	COG1129	ABC transporter
XCEL_RS12095	COG1940	carbohydrate kinase activity
XCEL_RS12105	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
XCEL_RS12110	COG1012	belongs to the aldehyde dehydrogenase family
XCEL_RS12110	COG1454	alcohol dehydrogenase
XCEL_RS12115	COG1505	serine-type exopeptidase activity
XCEL_RS12125	COG0482	sulfurtransferase activity
XCEL_RS12140	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
XCEL_RS12170	COG0366	Alpha amylase catalytic
XCEL_RS12180	COG3281	Trehalose synthase
XCEL_RS12185	COG2252	PERMEase
XCEL_RS12190	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
XCEL_RS12215	COG2267	carboxylic ester hydrolase activity
XCEL_RS12245	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
XCEL_RS12245	COG0574	Belongs to the PEP-utilizing enzyme family
XCEL_RS12265	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
XCEL_RS12270	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
XCEL_RS12275	COG1780	Probably involved in ribonucleotide reductase function
XCEL_RS12295	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
XCEL_RS12310	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
XCEL_RS12320	COG0355	proton-transporting ATP synthase activity, rotational mechanism
XCEL_RS12325	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
XCEL_RS12330	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
XCEL_RS12335	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
XCEL_RS12340	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
XCEL_RS12345	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
XCEL_RS12355	COG0356	it plays a direct role in the translocation of protons across the membrane
XCEL_RS12365	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
XCEL_RS12375	COG2890	protein-(glutamine-N5) methyltransferase activity
XCEL_RS12380	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
XCEL_RS12385	COG0254	rRNA binding
XCEL_RS12390	COG0438	transferase activity, transferring glycosyl groups
XCEL_RS12400	COG0083	homoserine kinase activity
XCEL_RS12405	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
XCEL_RS12410	COG0460	homoserine dehydrogenase
XCEL_RS12420	COG0018	arginyl-trna synthetase
XCEL_RS12480	COG2079	MmgE PrpD family protein
XCEL_RS12485	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
XCEL_RS12510	COG1253	flavin adenine dinucleotide binding
XCEL_RS12515	COG0745	RESPONSE REGULATOR receiver
XCEL_RS12520	COG2205	protein histidine kinase activity
XCEL_RS12525	COG0567	Dehydrogenase, E1 component
XCEL_RS12525	COG0508	dehydrogenase complex catalyzes the overall conversion of
XCEL_RS12530	COG0667	Aldo Keto reductase
XCEL_RS12535	COG2017	converts alpha-aldose to the beta-anomer
XCEL_RS12545	COG5662	AntiSigma factor
XCEL_RS12550	COG1595	DNA-templated transcription, initiation
XCEL_RS12560	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
XCEL_RS12570	COG0483	inositol monophosphate 1-phosphatase activity
XCEL_RS12580	COG2211	Major facilitator Superfamily
XCEL_RS12615	COG0653	protein targeting
XCEL_RS12620	COG3214	Protein conserved in bacteria
XCEL_RS12625	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
XCEL_RS12640	COG0577	efflux transmembrane transporter activity
XCEL_RS12640	COG1136	(ABC) transporter
XCEL_RS12650	COG5401	PFAM Sporulation and spore germination
XCEL_RS12655	COG5002	protein histidine kinase activity
XCEL_RS12660	COG0745	RESPONSE REGULATOR receiver
XCEL_RS12680	COG0714	Associated with various cellular activities
XCEL_RS12720	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
XCEL_RS12740	COG4176	ABC-type proline glycine betaine transport system permease component
XCEL_RS12755	COG2721	sulfolactate sulfo-lyase activity
XCEL_RS12760	COG1609	Transcriptional regulator
XCEL_RS12765	COG1175	transmembrane transport
XCEL_RS12770	COG0395	ABC-type sugar transport system, permease component
XCEL_RS12780	COG1028	Short-chain dehydrogenase reductase Sdr
XCEL_RS12785	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
XCEL_RS12790	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
XCEL_RS12795	COG2835	tetraacyldisaccharide 4'-kinase activity
XCEL_RS12800	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
XCEL_RS12805	COG1482	cell wall glycoprotein biosynthetic process
XCEL_RS12875	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
XCEL_RS12890	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
XCEL_RS12905	COG1088	dTDP-glucose 4,6-dehydratase activity
XCEL_RS12930	COG1216	Glycosyl transferase, family 2
XCEL_RS12960	COG1216	Glycosyl transferase, family 2
XCEL_RS13010	COG0463	Glycosyl transferase, family 2
XCEL_RS13015	COG1216	Glycosyl transferase, family 2
XCEL_RS13020	COG1215	transferase activity, transferring glycosyl groups
XCEL_RS13025	COG1134	teichoic acid transport
XCEL_RS13040	COG3475	LICD family
XCEL_RS13045	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
XCEL_RS13050	COG0438	transferase activity, transferring glycosyl groups
XCEL_RS13065	COG1316	TRANSCRIPTIONal
XCEL_RS13085	COG2205	protein histidine kinase activity
XCEL_RS13090	COG0745	RESPONSE REGULATOR receiver
XCEL_RS13100	COG2197	response regulator
XCEL_RS13110	COG1136	(ABC) transporter
XCEL_RS13110	COG0577	efflux transmembrane transporter activity
XCEL_RS13155	COG1175	transmembrane transport
XCEL_RS13160	COG0395	ABC-type sugar transport system, permease component
XCEL_RS13175	COG3459	Glycosyltransferase 36 associated
XCEL_RS13180	COG1012	belongs to the aldehyde dehydrogenase family
XCEL_RS13185	COG0656	L-ascorbic acid biosynthetic process
XCEL_RS13200	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
XCEL_RS13205	COG2890	protein-(glutamine-N5) methyltransferase activity
XCEL_RS13210	COG3253	May function as heme-dependent peroxidase
XCEL_RS13215	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
XCEL_RS13225	COG1929	Belongs to the glycerate kinase type-1 family
XCEL_RS13230	COG2409	Drug exporters of the RND superfamily
XCEL_RS13240	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
XCEL_RS13250	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
XCEL_RS13260	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
XCEL_RS13270	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
XCEL_RS13275	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
XCEL_RS13295	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
XCEL_RS13305	COG1793	dna ligase
XCEL_RS13325	COG2813	Specifically methylates the guanine in position
XCEL_RS13335	COG1175	transmembrane transport
XCEL_RS13340	COG0395	ABC-type sugar transport system, permease component
XCEL_RS13345	COG1904	glucuronate isomerase
XCEL_RS13375	COG0246	Mannitol dehydrogenase
XCEL_RS13380	COG0673	inositol 2-dehydrogenase activity
XCEL_RS13390	COG1609	Transcriptional regulator
XCEL_RS13395	COG4209	transmembrane transport
XCEL_RS13400	COG0395	ABC-type sugar transport system, permease component
XCEL_RS13425	COG0246	Mannitol dehydrogenase
XCEL_RS13430	COG1312	Catalyzes the dehydration of D-mannonate
XCEL_RS13445	COG3387	PFAM Glycoside hydrolase 15-related
XCEL_RS13470	COG2814	Major facilitator Superfamily
XCEL_RS13480	COG1252	NADH dehydrogenase
XCEL_RS13510	COG0148	phosphopyruvate hydratase activity
XCEL_RS13560	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
XCEL_RS13600	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
XCEL_RS13605	COG0673	inositol 2-dehydrogenase activity
XCEL_RS13620	COG0193	aminoacyl-tRNA hydrolase activity
XCEL_RS13625	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
XCEL_RS13635	COG0463	Glycosyl transferase, family 2
XCEL_RS13645	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
XCEL_RS13660	COG4152	abc transporter atp-binding protein
XCEL_RS13665	COG1668	transmembrane transport
XCEL_RS13675	COG2807	transmembrane transport
XCEL_RS13685	COG4585	Histidine kinase
XCEL_RS13690	COG2197	response regulator
XCEL_RS13715	COG0488	(ABC) transporter
XCEL_RS13720	COG3458	cephalosporin-C deacetylase activity
XCEL_RS13725	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
XCEL_RS13730	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
XCEL_RS13755	COG0084	hydrolase, TatD family'
XCEL_RS13760	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
XCEL_RS13775	COG1335	isochorismatase
XCEL_RS13810	COG1280	lysine exporter protein (LysE YggA)
XCEL_RS13855	COG1176	ABC-type spermidine putrescine transport system, permease component I
XCEL_RS13860	COG3842	ATPase activity
XCEL_RS13870	COG1609	Transcriptional regulator
XCEL_RS13880	COG1175	transmembrane transport
XCEL_RS13905	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
XCEL_RS13910	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
XCEL_RS13935	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
XCEL_RS13940	COG1105	Belongs to the carbohydrate kinase PfkB family
XCEL_RS13945	COG0723	plastoquinol--plastocyanin reductase activity
XCEL_RS13985	COG1752	Esterase of the alpha-beta hydrolase superfamily
XCEL_RS14005	COG2207	Transcriptional regulator
XCEL_RS14005	COG3708	Transcriptional regulator
XCEL_RS14020	COG1609	Transcriptional regulator
XCEL_RS14030	COG4209	transmembrane transport
XCEL_RS14035	COG0395	ABC-type sugar transport system, permease component
XCEL_RS14045	COG0657	acetylesterase activity
XCEL_RS14070	COG1253	flavin adenine dinucleotide binding
XCEL_RS14095	COG0366	Alpha amylase catalytic
XCEL_RS14100	COG1609	Transcriptional regulator
XCEL_RS14125	COG1136	(ABC) transporter
XCEL_RS14125	COG4591	ABC-type transport system involved in lipoprotein release permease component
XCEL_RS14130	COG1136	(ABC) transporter
XCEL_RS14130	COG0577	efflux transmembrane transporter activity
XCEL_RS14175	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
XCEL_RS14195	COG1970	mechanosensitive ion channel activity
XCEL_RS14210	COG3173	Aminoglycoside phosphotransferase
XCEL_RS14215	COG1136	(ABC) transporter
XCEL_RS14215	COG0577	efflux transmembrane transporter activity
XCEL_RS14245	COG2115	Belongs to the xylose isomerase family
XCEL_RS14250	COG1070	Carbohydrate kinase
XCEL_RS14315	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
XCEL_RS14340	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
XCEL_RS14345	COG2814	Major facilitator Superfamily
XCEL_RS14350	COG2814	Major facilitator Superfamily
XCEL_RS14355	COG1846	Transcriptional regulator
XCEL_RS14375	COG3206	protein involved in exopolysaccharide biosynthesis
XCEL_RS14375	COG0489	protein tyrosine kinase activity
XCEL_RS14385	COG2770	Histidine kinase
XCEL_RS14385	COG2208	phosphoserine phosphatase activity
XCEL_RS14440	COG0028	Belongs to the TPP enzyme family
XCEL_RS14535	COG0489	protein tyrosine kinase activity
XCEL_RS14595	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
XCEL_RS14620	COG1609	Transcriptional regulator
XCEL_RS14625	COG0395	ABC-type sugar transport system, permease component
XCEL_RS14630	COG1175	transmembrane transport
XCEL_RS14660	COG1487	ribonuclease activity
XCEL_RS14685	COG2252	PERMEase
XCEL_RS14690	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
XCEL_RS14710	COG1278	Cold shock
XCEL_RS14720	COG1061	Type III restriction enzyme res subunit
XCEL_RS14730	COG1842	Phage shock protein A
XCEL_RS14745	COG0745	RESPONSE REGULATOR receiver
XCEL_RS14750	COG2205	protein histidine kinase activity
XCEL_RS14765	COG0459	protein refolding
XCEL_RS14780	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
XCEL_RS14810	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
XCEL_RS14815	COG3842	ATPase activity
XCEL_RS14825	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
XCEL_RS14830	COG0215	cysteine-tRNA ligase activity
XCEL_RS14850	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
XCEL_RS14855	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
XCEL_RS14860	COG1329	Transcriptional regulator
XCEL_RS14870	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
XCEL_RS14890	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
XCEL_RS14910	COG0745	RESPONSE REGULATOR receiver
XCEL_RS14915	COG5002	protein histidine kinase activity
XCEL_RS14920	COG0704	Plays a role in the regulation of phosphate uptake
XCEL_RS14925	COG0588	phosphoglycerate mutase activity
XCEL_RS14930	COG0297	glycogen (starch) synthase activity
XCEL_RS14950	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
XCEL_RS14985	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
XCEL_RS14990	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
XCEL_RS14995	COG0302	gtp cyclohydrolase
XCEL_RS15000	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
XCEL_RS15005	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
XCEL_RS15010	COG0037	tRNA processing
XCEL_RS15025	COG0745	RESPONSE REGULATOR receiver
XCEL_RS15030	COG1840	ABC-type Fe3 transport system, periplasmic component
XCEL_RS15040	COG3842	ATPase activity
XCEL_RS15045	COG2027	D-alanyl-D-alanine carboxypeptidase
XCEL_RS15050	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
XCEL_RS15055	COG1063	alcohol dehydrogenase
XCEL_RS15060	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
XCEL_RS15065	COG0791	NLP P60 protein
XCEL_RS15065	COG3883	PFAM NLP P60 protein
XCEL_RS15075	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
XCEL_RS15090	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
XCEL_RS15110	COG0391	Required for morphogenesis under gluconeogenic growth conditions
XCEL_RS15115	COG1920	GTP binding
XCEL_RS15135	COG0778	Nitroreductase
XCEL_RS15145	COG0247	lactate metabolic process
XCEL_RS15145	COG0277	FAD linked oxidase domain protein
XCEL_RS15175	COG1490	D-aminoacyl-tRNA deacylase activity
XCEL_RS15200	COG4129	membrane
XCEL_RS15205	COG0404	The glycine cleavage system catalyzes the degradation of glycine
XCEL_RS15210	COG3485	protocatechuate 3,4-dioxygenase
XCEL_RS15235	COG0745	RESPONSE REGULATOR receiver
XCEL_RS15240	COG0596	Alpha beta hydrolase
XCEL_RS15265	COG1408	metallophosphoesterase
XCEL_RS15330	COG1120	ATPase activity
XCEL_RS15335	COG0577	efflux transmembrane transporter activity
XCEL_RS15335	COG1136	(ABC) transporter
XCEL_RS15340	COG0577	efflux transmembrane transporter activity
XCEL_RS15365	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
XCEL_RS15415	COG1268	BioY protein
XCEL_RS15425	COG0183	Belongs to the thiolase family
XCEL_RS15430	COG1122	ATPase activity
XCEL_RS15450	COG0494	nUDIX hydrolase
XCEL_RS15460	COG0584	glycerophosphoryl diester phosphodiesterase
XCEL_RS15470	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
XCEL_RS15515	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
XCEL_RS15530	COG0737	Belongs to the 5'-nucleotidase family
XCEL_RS15545	COG2116	formate transmembrane transporter activity
XCEL_RS15560	COG0778	Nitroreductase
XCEL_RS15570	COG2838	Isocitrate dehydrogenase
XCEL_RS15585	COG1216	Glycosyl transferase, family 2
XCEL_RS15590	COG2244	polysaccharide biosynthetic process
XCEL_RS15605	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
XCEL_RS15645	COG2030	dehydratase
XCEL_RS15660	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
XCEL_RS15700	COG0047	phosphoribosylformylglycinamidine synthase activity
XCEL_RS15705	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
XCEL_RS15735	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
XCEL_RS15740	COG0151	Belongs to the GarS family
XCEL_RS15760	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
XCEL_RS15790	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
XCEL_RS15805	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
XCEL_RS15810	COG4221	oxidoreductase activity
XCEL_RS15820	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
XCEL_RS15825	COG0601	transmembrane transport
XCEL_RS15845	COG0708	Exodeoxyribonuclease III
XCEL_RS15850	COG1136	(ABC) transporter
XCEL_RS15850	COG0577	efflux transmembrane transporter activity
XCEL_RS15855	COG0577	efflux transmembrane transporter activity
XCEL_RS15855	COG1136	(ABC) transporter
XCEL_RS15905	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
XCEL_RS15910	COG0601	transmembrane transport
XCEL_RS15960	COG2197	response regulator
XCEL_RS15970	COG2169	Transcriptional regulator
XCEL_RS15970	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
XCEL_RS15990	COG0651	ATP synthesis coupled electron transport
XCEL_RS15995	COG1006	Multisubunit Na H antiporter MnhC subunit
XCEL_RS16000	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
XCEL_RS16000	COG2111	Na H antiporter
XCEL_RS16010	COG0717	Belongs to the dCTP deaminase family
XCEL_RS16045	COG1309	transcriptional regulator
XCEL_RS16055	COG2909	trisaccharide binding
XCEL_RS16070	COG1082	Xylose isomerase domain protein TIM barrel
XCEL_RS16075	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
XCEL_RS16080	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
XCEL_RS16085	COG2190	(PTS) system
XCEL_RS16095	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
XCEL_RS16100	COG0574	Belongs to the PEP-utilizing enzyme family
XCEL_RS16100	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
XCEL_RS16140	COG0656	L-ascorbic acid biosynthetic process
XCEL_RS16160	COG2409	Drug exporters of the RND superfamily
XCEL_RS16170	COG3336	cytochrome c oxidase
XCEL_RS16175	COG0508	dehydrogenase complex catalyzes the overall conversion of
XCEL_RS16180	COG0022	dehydrogenase e1 component
XCEL_RS16190	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
XCEL_RS16195	COG1950	PFAM Membrane protein of
XCEL_RS16210	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
XCEL_RS16240	COG5006	permease, DMT superfamily
XCEL_RS16245	COG0248	Ppx GppA phosphatase
XCEL_RS16255	COG0395	ABC-type sugar transport system, permease component
XCEL_RS16260	COG1175	transmembrane transport
XCEL_RS16265	COG1653	transport
XCEL_RS16280	COG1396	sequence-specific DNA binding
XCEL_RS16285	COG0561	phosphatase activity
XCEL_RS16290	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
XCEL_RS16295	COG1597	lipid kinase activity
XCEL_RS16305	COG1215	transferase activity, transferring glycosyl groups
XCEL_RS16315	COG1804	L-carnitine dehydratase bile acid-inducible protein F
XCEL_RS16320	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
XCEL_RS16325	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
XCEL_RS16335	COG3177	Filamentation induced by cAMP protein fic
XCEL_RS16340	COG0181	hydroxymethylbilane synthase activity
XCEL_RS16350	COG0113	porphobilinogen synthase activity
XCEL_RS16355	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
XCEL_RS16365	COG1937	Protein conserved in bacteria
XCEL_RS16390	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
XCEL_RS16395	COG0601	transmembrane transport
XCEL_RS16410	COG3657	addiction module killer protein
XCEL_RS16415	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
XCEL_RS16465	COG1672	PFAM Archaeal ATPase
XCEL_RS16465	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
XCEL_RS16480	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
XCEL_RS16485	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
XCEL_RS16490	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
XCEL_RS16505	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
XCEL_RS16510	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
XCEL_RS16525	COG2353	YceI-like domain
XCEL_RS16540	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
XCEL_RS16555	COG2318	DinB family
XCEL_RS16595	COG1834	amidinotransferase
XCEL_RS16635	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
XCEL_RS16655	COG2239	Acts as a magnesium transporter
XCEL_RS16675	COG1131	(ABC) transporter
XCEL_RS16685	COG3845	ABC transporter
XCEL_RS16705	COG2197	response regulator
XCEL_RS16715	COG3744	PilT protein domain protein
XCEL_RS16740	COG1733	regulation of RNA biosynthetic process
XCEL_RS16750	COG1619	proteins homologs of microcin C7 resistance protein MccF
XCEL_RS16760	COG0596	Alpha beta hydrolase
XCEL_RS16770	COG0477	Major facilitator Superfamily
XCEL_RS16790	COG0446	pyridine nucleotide-disulphide oxidoreductase
XCEL_RS16795	COG2226	methyltransferase
XCEL_RS16800	COG0640	Transcriptional regulator
XCEL_RS16810	COG0305	Participates in initiation and elongation during chromosome replication
XCEL_RS16815	COG0534	Mate efflux family protein
XCEL_RS16820	COG0359	binds to the 23S rRNA
XCEL_RS16825	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
XCEL_RS16835	COG0360	Binds together with S18 to 16S ribosomal RNA
XCEL_RS16840	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
XCEL_RS16845	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
XCEL_RS16850	COG1695	Transcriptional regulator
XCEL_RS16855	COG1260	myo-inositol-1-phosphate synthase
XCEL_RS16865	COG2814	Major facilitator Superfamily
XCEL_RS16870	COG0617	tRNA 3'-terminal CCA addition
XCEL_RS16895	COG0492	ferredoxin-NADP+ reductase activity
XCEL_RS16900	COG3118	belongs to the thioredoxin family
XCEL_RS16905	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
XCEL_RS16910	COG1181	Belongs to the D-alanine--D-alanine ligase family
XCEL_RS16920	COG1192	Involved in chromosome partitioning
XCEL_RS16925	COG0357	Ribosomal RNA small subunit methyltransferase G
XCEL_RS16935	COG0706	membrane insertase activity
XCEL_RS16940	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
XCEL_RS16945	COG0594	ribonuclease P activity
XCEL_RS16950	COG0230	Belongs to the bacterial ribosomal protein bL34 family
XCEL_RS16960	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
XCEL_RS17420	COG1643	Atp-dependent helicase
XCEL_RS17570	COG2314	TM2 domain
XCEL_RS17635	COG1051	belongs to the nudix hydrolase family
XCEL_RS17680	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
XCEL_RS17730	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
XCEL_RS17730	COG1199	ATP-dependent helicase activity
XCEL_RS17780	COG1316	TRANSCRIPTIONal
XCEL_RS17790	COG1070	Carbohydrate kinase