locus-tag	class	description
XFFB_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
XFFB_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
XFFB_RS00025	COG0187	DNA topoisomerase II activity
XFFB_RS00035	COG0501	Belongs to the peptidase M48B family
XFFB_RS00075	COG0408	coproporphyrinogen oxidase activity
XFFB_RS00100	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
XFFB_RS00115	COG4969	Belongs to the N-Me-Phe pilin family
XFFB_RS00145	COG0284	orotidine-5'-phosphate decarboxylase activity
XFFB_RS00185	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
XFFB_RS00195	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
XFFB_RS00205	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
XFFB_RS00210	COG0511	ligase activity, forming carbon-carbon bonds
XFFB_RS00215	COG0439	Biotin carboxylase
XFFB_RS00220	COG0210	DNA helicase
XFFB_RS00230	COG1017	nitric oxide dioxygenase activity
XFFB_RS00230	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
XFFB_RS00245	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
XFFB_RS00255	COG1040	competence protein
XFFB_RS00260	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
XFFB_RS00265	COG1752	Esterase of the alpha-beta hydrolase superfamily
XFFB_RS00275	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
XFFB_RS00310	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
XFFB_RS00320	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
XFFB_RS00355	COG3121	Chaperone
XFFB_RS00360	COG3539	Fimbrial protein
XFFB_RS00365	COG1546	Belongs to the CinA family
XFFB_RS00370	COG0477	Major facilitator Superfamily
XFFB_RS00375	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
XFFB_RS00380	COG1923	regulation of RNA biosynthetic process
XFFB_RS00385	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
XFFB_RS00390	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
XFFB_RS00400	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
XFFB_RS00410	COG1534	Rna-binding protein
XFFB_RS00420	COG0129	dihydroxy-acid dehydratase activity
XFFB_RS00445	COG1560	Kdo2-lipid A biosynthetic process
XFFB_RS00450	COG1519	Transferase
XFFB_RS00460	COG0228	four-way junction DNA binding
XFFB_RS00465	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
XFFB_RS00470	COG0336	Belongs to the RNA methyltransferase TrmD family
XFFB_RS00475	COG0335	large ribosomal subunit rRNA binding
XFFB_RS00495	COG2171	N-acyltransferase activity
XFFB_RS00500	COG1393	Belongs to the ArsC family
XFFB_RS00505	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
XFFB_RS00510	COG0367	asparagine synthase
XFFB_RS00520	COG2070	2-Nitropropane dioxygenase
XFFB_RS00525	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
XFFB_RS00530	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
XFFB_RS00550	COG0339	signal peptide processing
XFFB_RS00595	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
XFFB_RS00615	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
XFFB_RS00625	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
XFFB_RS00630	COG1166	arginine decarboxylase activity
XFFB_RS00635	COG4221	oxidoreductase activity
XFFB_RS00645	COG0018	arginyl-trna synthetase
XFFB_RS00650	COG2003	Belongs to the UPF0758 family
XFFB_RS00655	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
XFFB_RS00665	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
XFFB_RS00675	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
XFFB_RS00720	COG2223	nitrite transmembrane transporter activity
XFFB_RS00730	COG0739	heme binding
XFFB_RS00735	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
XFFB_RS00765	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
XFFB_RS00785	COG1028	Short-chain dehydrogenase reductase Sdr
XFFB_RS00790	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
XFFB_RS00795	COG1272	protein, Hemolysin III
XFFB_RS00800	COG0463	Glycosyl transferase, family 2
XFFB_RS00805	COG0084	hydrolase, TatD family'
XFFB_RS00820	COG0509	glycine decarboxylation via glycine cleavage system
XFFB_RS00825	COG0404	The glycine cleavage system catalyzes the degradation of glycine
XFFB_RS00835	COG0330	HflC and HflK could
XFFB_RS00840	COG3956	TIGRFAM MazG family protein
XFFB_RS00845	COG1218	3'(2'),5'-bisphosphate nucleotidase
XFFB_RS00850	COG0494	nUDIX hydrolase
XFFB_RS00860	COG1385	rRNA (uridine-N3-)-methyltransferase activity
XFFB_RS00870	COG0513	Belongs to the DEAD box helicase family
XFFB_RS00875	COG0720	synthase
XFFB_RS00910	COG1981	membrane
XFFB_RS00915	COG0825	malonyl-CoA metabolic process
XFFB_RS00920	COG0587	DNA-directed DNA polymerase activity
XFFB_RS00925	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
XFFB_RS00950	COG0512	Glutamine amidotransferase of anthranilate synthase
XFFB_RS00955	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
XFFB_RS00960	COG0134	indole-3-glycerol-phosphate synthase activity
XFFB_RS00985	COG0006	proline dipeptidase activity
XFFB_RS01000	COG0343	queuine tRNA-ribosyltransferase activity
XFFB_RS01005	COG1862	Preprotein translocase
XFFB_RS01010	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
XFFB_RS01015	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
XFFB_RS01025	COG0617	tRNA 3'-terminal CCA addition
XFFB_RS01035	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
XFFB_RS01065	COG0779	Required for maturation of 30S ribosomal subunits
XFFB_RS01070	COG0195	Participates in both transcription termination and antitermination
XFFB_RS01075	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
XFFB_RS01080	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
XFFB_RS01085	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
XFFB_RS01095	COG1185	polyribonucleotide nucleotidyltransferase activity
XFFB_RS01100	COG1733	regulation of RNA biosynthetic process
XFFB_RS01105	COG0702	epimerase
XFFB_RS01190	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
XFFB_RS01260	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
XFFB_RS01270	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
XFFB_RS01275	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XFFB_RS01280	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XFFB_RS01285	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
XFFB_RS01290	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XFFB_RS01300	COG0750	zinc metalloprotease
XFFB_RS01305	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
XFFB_RS01310	COG0575	Belongs to the CDS family
XFFB_RS01315	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
XFFB_RS01320	COG0233	cytoplasmic translational termination
XFFB_RS01325	COG2067	long-chain fatty acid transport protein
XFFB_RS01350	COG0528	UMP kinase activity
XFFB_RS01385	COG0363	glucosamine-6-phosphate deaminase activity
XFFB_RS01390	COG0837	glucose binding
XFFB_RS01395	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
XFFB_RS01400	COG3842	ATPase activity
XFFB_RS01405	COG0354	folic acid binding
XFFB_RS01415	COG2009	succinate dehydrogenase
XFFB_RS01420	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
XFFB_RS01430	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
XFFB_RS01435	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
XFFB_RS01445	COG4591	ABC-type transport system involved in lipoprotein release permease component
XFFB_RS01450	COG1136	(ABC) transporter
XFFB_RS01460	COG0811	peptide transport
XFFB_RS01475	COG1663	tetraacyldisaccharide 4'-kinase activity
XFFB_RS01495	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XFFB_RS01525	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
XFFB_RS01555	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
XFFB_RS01560	COG0505	Belongs to the CarA family
XFFB_RS01570	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
XFFB_RS01580	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
XFFB_RS01585	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
XFFB_RS01590	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
XFFB_RS01605	COG1024	Enoyl-CoA hydratase
XFFB_RS01610	COG0019	diaminopimelate decarboxylase activity
XFFB_RS01620	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
XFFB_RS01630	COG0494	nUDIX hydrolase
XFFB_RS01645	COG0424	maF-like protein
XFFB_RS01660	COG0312	modulator of DNA gyrase
XFFB_RS01665	COG3028	Belongs to the UPF0307 family
XFFB_RS01670	COG0312	modulator of DNA gyrase
XFFB_RS01675	COG0583	DNA-binding transcription factor activity
XFFB_RS01680	COG0655	NAD(P)H dehydrogenase (quinone) activity
XFFB_RS01690	COG1064	alcohol dehydrogenase
XFFB_RS01705	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
XFFB_RS01715	COG0355	proton-transporting ATP synthase activity, rotational mechanism
XFFB_RS01720	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
XFFB_RS01725	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
XFFB_RS01730	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
XFFB_RS01735	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
XFFB_RS01740	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
XFFB_RS01750	COG0356	it plays a direct role in the translocation of protons across the membrane
XFFB_RS01770	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
XFFB_RS01775	COG0088	Forms part of the polypeptide exit tunnel
XFFB_RS01780	COG0089	rRNA binding
XFFB_RS01785	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
XFFB_RS01790	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
XFFB_RS01795	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
XFFB_RS01800	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
XFFB_RS01810	COG0255	Belongs to the universal ribosomal protein uL29 family
XFFB_RS01815	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
XFFB_RS01825	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
XFFB_RS01830	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
XFFB_RS01835	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
XFFB_RS01840	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
XFFB_RS01845	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
XFFB_RS01855	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
XFFB_RS01860	COG1841	ribosomal large subunit assembly
XFFB_RS01865	COG0200	Binds to the 23S rRNA
XFFB_RS01870	COG0201	protein transport
XFFB_RS01875	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
XFFB_RS01880	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
XFFB_RS01885	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
XFFB_RS01895	COG0203	ribosomal protein L17
XFFB_RS01900	COG2960	long-chain fatty acid transporting porin activity
XFFB_RS01915	COG5380	lipid catabolic process
XFFB_RS01925	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
XFFB_RS01940	COG0544	peptidyl-prolyl cis-trans isomerase activity
XFFB_RS01945	COG0740	serine-type endopeptidase activity
XFFB_RS01950	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
XFFB_RS01995	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
XFFB_RS02000	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
XFFB_RS02050	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XFFB_RS02055	COG0625	glutathione transferase activity
XFFB_RS02060	COG0039	L-malate dehydrogenase activity
XFFB_RS02065	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
XFFB_RS02070	COG1217	gtp-binding protein TYPA
XFFB_RS02115	COG1131	(ABC) transporter
XFFB_RS02140	COG1643	Atp-dependent helicase
XFFB_RS02145	COG1956	GAF domain-containing protein
XFFB_RS02150	COG0729	surface antigen
XFFB_RS02155	COG2911	Protein conserved in bacteria
XFFB_RS02170	COG0582	viral genome integration into host DNA
XFFB_RS02345	COG2373	Large extracellular alpha-helical protein
XFFB_RS02365	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
XFFB_RS02370	COG0668	transmembrane transport
XFFB_RS02380	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
XFFB_RS02400	COG5297	Belongs to the glycosyl hydrolase family 6
XFFB_RS02405	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
XFFB_RS02410	COG0321	lipoyl(octanoyl) transferase activity
XFFB_RS02415	COG2921	Belongs to the UPF0250 family
XFFB_RS02435	COG2733	membrane
XFFB_RS02440	COG1253	flavin adenine dinucleotide binding
XFFB_RS02470	COG0504	CTP synthase activity
XFFB_RS02475	COG2877	3-deoxy-8-phosphooctulonate synthase activity
XFFB_RS02480	COG0148	phosphopyruvate hydratase activity
XFFB_RS02485	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
XFFB_RS02490	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
XFFB_RS02495	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
XFFB_RS02500	COG2840	Smr protein MutS2
XFFB_RS02510	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
XFFB_RS02510	COG0644	oxidoreductase
XFFB_RS02525	COG3218	ABC-type transport auxiliary lipoprotein component
XFFB_RS02525	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
XFFB_RS02530	COG1127	ABC transporter
XFFB_RS02535	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
XFFB_RS02590	COG1077	Cell shape determining protein MreB Mrl
XFFB_RS02595	COG1792	Involved in formation and maintenance of cell shape
XFFB_RS02600	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
XFFB_RS02605	COG0768	penicillin binding
XFFB_RS02610	COG0772	Belongs to the SEDS family
XFFB_RS02615	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
XFFB_RS02620	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
XFFB_RS02640	COG2894	cell division
XFFB_RS02645	COG0850	regulation of cytokinetic process
XFFB_RS02665	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
XFFB_RS02675	COG3038	cytochrome b561
XFFB_RS02680	COG2353	YceI-like domain
XFFB_RS02685	COG2205	protein histidine kinase activity
XFFB_RS02685	COG2198	Histidine kinase
XFFB_RS02685	COG0784	Response regulator, receiver
XFFB_RS02695	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
XFFB_RS02705	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
XFFB_RS02710	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
XFFB_RS02720	COG0259	pyridoxamine-phosphate oxidase activity
XFFB_RS02725	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
XFFB_RS02750	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
XFFB_RS02755	COG4208	sulfate ABC transporter
XFFB_RS02760	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
XFFB_RS02770	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
XFFB_RS02780	COG1846	Transcriptional regulator
XFFB_RS02790	COG2267	carboxylic ester hydrolase activity
XFFB_RS02795	COG0156	8-amino-7-oxononanoate synthase activity
XFFB_RS02805	COG0109	protoheme IX farnesyltransferase activity
XFFB_RS02810	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
XFFB_RS02815	COG0617	tRNA 3'-terminal CCA addition
XFFB_RS02820	COG0741	lytic transglycosylase activity
XFFB_RS02830	COG0688	phosphatidylethanolamine metabolic process
XFFB_RS02840	COG2890	protein-(glutamine-N5) methyltransferase activity
XFFB_RS02845	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
XFFB_RS02855	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
XFFB_RS02865	COG0101	tRNA pseudouridine synthase activity
XFFB_RS02870	COG0135	phosphoribosylanthranilate isomerase activity
XFFB_RS02875	COG0133	tryptophan synthase activity
XFFB_RS02880	COG0159	tryptophan synthase activity
XFFB_RS02890	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
XFFB_RS02900	COG0514	ATP-dependent DNA helicase (RecQ)
XFFB_RS02905	COG0783	Belongs to the Dps family
XFFB_RS02910	COG1643	Atp-dependent helicase
XFFB_RS02925	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
XFFB_RS02925	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
XFFB_RS02930	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
XFFB_RS02935	COG1845	cytochrome c oxidase, subunit III
XFFB_RS02940	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
XFFB_RS02945	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
XFFB_RS02950	COG0142	geranyltranstransferase activity
XFFB_RS02960	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
XFFB_RS02980	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
XFFB_RS02985	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
XFFB_RS02995	COG1660	Displays ATPase and GTPase activities
XFFB_RS03015	COG1137	ATPase activity
XFFB_RS03030	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
XFFB_RS03040	COG0271	Belongs to the BolA IbaG family
XFFB_RS03045	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
XFFB_RS03090	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
XFFB_RS03095	COG4974	Belongs to the 'phage' integrase family
XFFB_RS03100	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
XFFB_RS03105	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
XFFB_RS03115	COG0218	Necessary for normal cell division and for the maintenance of normal septation
XFFB_RS03140	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
XFFB_RS03150	COG2915	High frequency lysogenization protein hflD homolog
XFFB_RS03165	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
XFFB_RS03170	COG0542	response to heat
XFFB_RS03180	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
XFFB_RS03185	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
XFFB_RS03195	COG0492	ferredoxin-NADP+ reductase activity
XFFB_RS03200	COG1674	ftsk spoiiie
XFFB_RS03210	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
XFFB_RS03215	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
XFFB_RS03220	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
XFFB_RS03225	COG4191	Histidine kinase
XFFB_RS03230	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
XFFB_RS03235	COG1028	Short-chain dehydrogenase reductase Sdr
XFFB_RS03250	COG0837	glucose binding
XFFB_RS03265	COG1609	Transcriptional regulator
XFFB_RS03270	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
XFFB_RS03275	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
XFFB_RS03280	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
XFFB_RS03285	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
XFFB_RS03290	COG0726	polysaccharide deacetylase
XFFB_RS03295	COG0297	glycogen (starch) synthase activity
XFFB_RS03310	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
XFFB_RS03320	COG0396	ATPase activity
XFFB_RS03325	COG0719	Fe-S assembly protein
XFFB_RS03330	COG1959	2 iron, 2 sulfur cluster binding
XFFB_RS03350	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
XFFB_RS03360	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
XFFB_RS03370	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
XFFB_RS03380	COG2226	methyltransferase
XFFB_RS03385	COG0308	aminopeptidase N
XFFB_RS03410	COG2912	Transglutaminase-like superfamily
XFFB_RS03425	COG0175	sulfate reduction
XFFB_RS03430	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
XFFB_RS03440	COG0175	sulfate reduction
XFFB_RS03445	COG0529	Catalyzes the synthesis of activated sulfate
XFFB_RS03445	COG2895	sulfate adenylyltransferase (ATP) activity
XFFB_RS03450	COG1758	RNA polymerase activity
XFFB_RS03455	COG0194	GDP metabolic process
XFFB_RS03460	COG1561	YicC-like family, N-terminal region
XFFB_RS03465	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
XFFB_RS03470	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
XFFB_RS03475	COG0635	Involved in the biosynthesis of porphyrin-containing compound
XFFB_RS03490	COG0596	Alpha beta hydrolase
XFFB_RS03500	COG2890	protein-(glutamine-N5) methyltransferase activity
XFFB_RS03520	COG5295	Hep Hag repeat protein
XFFB_RS03525	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
XFFB_RS03530	COG1459	type II secretion system
XFFB_RS03535	COG2165	general secretion pathway protein
XFFB_RS03540	COG4970	Tfp pilus assembly protein FimT
XFFB_RS03545	COG2165	general secretion pathway protein
XFFB_RS03550	COG4795	General secretion pathway protein
XFFB_RS03555	COG3156	type II secretion system protein K
XFFB_RS03560	COG3166	PFAM Fimbrial assembly family protein
XFFB_RS03575	COG1450	Type ii and iii secretion system protein
XFFB_RS03595	COG3634	alkyl hydroperoxide reductase activity
XFFB_RS03600	COG0583	DNA-binding transcription factor activity
XFFB_RS03620	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
XFFB_RS03625	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
XFFB_RS03630	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
XFFB_RS03665	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
XFFB_RS03690	COG0567	Dehydrogenase, E1 component
XFFB_RS03695	COG2850	peptidyl-arginine hydroxylation
XFFB_RS03875	COG0445	tRNA wobble uridine modification
XFFB_RS03915	COG1469	GTP cyclohydrolase I activity
XFFB_RS03925	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XFFB_RS03930	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XFFB_RS03945	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
XFFB_RS03980	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XFFB_RS03985	COG1028	Short-chain dehydrogenase reductase Sdr
XFFB_RS03990	COG3077	Addiction module antitoxin, RelB DinJ family
XFFB_RS03995	COG3041	Addiction module toxin RelE StbE family
XFFB_RS04030	COG4691	Plasmid stability protein
XFFB_RS04035	COG3609	addiction module antidote protein, CC2985 family
XFFB_RS04180	COG0629	single-stranded DNA binding
XFFB_RS04205	COG3451	type IV secretory pathway VirB4
XFFB_RS04265	COG0596	Alpha beta hydrolase
XFFB_RS04310	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
XFFB_RS04345	COG2925	Exonuclease
XFFB_RS04360	COG0025	NhaP-type Na H and K H
XFFB_RS04370	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
XFFB_RS04380	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
XFFB_RS04400	COG3079	Belongs to the UPF0149 family
XFFB_RS04405	COG0006	proline dipeptidase activity
XFFB_RS04450	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
XFFB_RS04455	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
XFFB_RS04490	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
XFFB_RS04495	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
XFFB_RS04505	COG0557	exoribonuclease II activity
XFFB_RS04515	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
XFFB_RS04520	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
XFFB_RS04525	COG0302	gtp cyclohydrolase
XFFB_RS04540	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
XFFB_RS04545	COG1289	transmembrane transporter activity
XFFB_RS04555	COG0151	Belongs to the GarS family
XFFB_RS04560	COG0138	bifunctional purine biosynthesis protein purh
XFFB_RS04575	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
XFFB_RS04585	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
XFFB_RS04605	COG0596	Alpha beta hydrolase
XFFB_RS04610	COG0727	PFAM Uncharacterised protein family (UPF0153)
XFFB_RS04625	COG0752	glycyl-tRNA synthetase alpha subunit
XFFB_RS04630	COG0751	glycine-tRNA ligase activity
XFFB_RS04645	COG0189	ligase activity
XFFB_RS04660	COG0840	transmembrane signaling receptor activity
XFFB_RS04665	COG0784	Response regulator, receiver
XFFB_RS04665	COG2198	Histidine kinase
XFFB_RS04665	COG0643	Histidine kinase
XFFB_RS04695	COG0285	dihydrofolate synthase activity
XFFB_RS04705	COG0339	signal peptide processing
XFFB_RS04730	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
XFFB_RS04735	COG1301	dicarboxylic acid transport
XFFB_RS04740	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
XFFB_RS04745	COG0357	Ribosomal RNA small subunit methyltransferase G
XFFB_RS04750	COG2091	lysine biosynthetic process via aminoadipic acid
XFFB_RS04815	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
XFFB_RS04820	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
XFFB_RS04830	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
XFFB_RS04835	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
XFFB_RS04870	COG0084	hydrolase, TatD family'
XFFB_RS04885	COG0552	protein localization to endoplasmic reticulum
XFFB_RS04895	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
XFFB_RS04905	COG0217	transcriptional regulatory protein
XFFB_RS04910	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
XFFB_RS04915	COG0632	four-way junction helicase activity
XFFB_RS04920	COG3158	transport of potassium into the cell
XFFB_RS04925	COG2255	four-way junction helicase activity
XFFB_RS04930	COG0824	Thioesterase
XFFB_RS04950	COG0823	Involved in the tonB-independent uptake of proteins
XFFB_RS04955	COG2885	chlorophyll binding
XFFB_RS04965	COG0602	queuosine metabolic process
XFFB_RS04970	COG0588	phosphoglycerate mutase activity
XFFB_RS04975	COG1515	deoxyribonuclease V activity
XFFB_RS04985	COG0386	Belongs to the glutathione peroxidase family
XFFB_RS04995	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
XFFB_RS05005	COG0406	alpha-ribazole phosphatase activity
XFFB_RS05220	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
XFFB_RS05225	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
XFFB_RS05260	COG0675	Transposase, IS605 OrfB family
XFFB_RS05265	COG3852	Histidine kinase
XFFB_RS05270	COG2204	response regulator
XFFB_RS05280	COG0004	ammonium transporteR
XFFB_RS05285	COG0347	Belongs to the P(II) protein family
XFFB_RS05290	COG0174	glutamine synthetase
XFFB_RS05300	COG2353	YceI-like domain
XFFB_RS05360	COG3657	addiction module killer protein
XFFB_RS05365	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
XFFB_RS05400	COG2026	Addiction module toxin, RelE StbE family
XFFB_RS05475	COG2369	cell adhesion
XFFB_RS05480	COG3567	Phage-associated protein, HI1409 family
XFFB_RS05485	COG5410	chromosome segregation
XFFB_RS05510	COG3772	lysozyme
XFFB_RS05540	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
XFFB_RS05660	COG3617	BRO family, N-terminal domain
XFFB_RS05685	COG0629	single-stranded DNA binding
XFFB_RS05705	COG0556	nucleotide-excision repair
XFFB_RS05750	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
XFFB_RS05755	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
XFFB_RS05760	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
XFFB_RS05775	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
XFFB_RS05775	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
XFFB_RS05780	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
XFFB_RS05790	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
XFFB_RS05795	COG0488	(ABC) transporter
XFFB_RS05800	COG0579	oxidoreductase
XFFB_RS05805	COG3011	Protein conserved in bacteria
XFFB_RS05810	COG1496	oxidoreductase activity
XFFB_RS05815	COG0564	pseudouridine synthase activity
XFFB_RS05840	COG1918	ferrous iron import across plasma membrane
XFFB_RS05840	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
XFFB_RS05850	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
XFFB_RS05860	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
XFFB_RS05875	COG0758	DNA mediated transformation
XFFB_RS05880	COG2922	Belongs to the Smg family
XFFB_RS05885	COG1754	DNA topoisomerase type I activity
XFFB_RS05885	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
XFFB_RS05890	COG0009	L-threonylcarbamoyladenylate synthase
XFFB_RS05925	COG2969	positive regulation of protein catabolic process
XFFB_RS05935	COG2857	Cytochrome c1
XFFB_RS05940	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
XFFB_RS05945	COG0723	plastoquinol--plastocyanin reductase activity
XFFB_RS05955	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
XFFB_RS05960	COG1702	phosphate starvation-inducible protein PhoH
XFFB_RS05965	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
XFFB_RS05975	COG4535	Mg2 and Co2 transporter CorC
XFFB_RS06055	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
XFFB_RS06060	COG0277	FAD linked oxidase domain protein
XFFB_RS06065	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
XFFB_RS06070	COG0531	amino acid
XFFB_RS06075	COG0531	amino acid
XFFB_RS06080	COG0235	Class ii aldolase
XFFB_RS06085	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
XFFB_RS06090	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
XFFB_RS06095	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
XFFB_RS06095	COG0140	phosphoribosyl-ATP diphosphatase activity
XFFB_RS06105	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
XFFB_RS06115	COG0131	Imidazoleglycerol-phosphate dehydratase
XFFB_RS06115	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
XFFB_RS06125	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
XFFB_RS06130	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
XFFB_RS06140	COG0124	histidyl-tRNA synthetase
XFFB_RS06150	COG0083	homoserine kinase activity
XFFB_RS06155	COG0527	aspartate kinase activity
XFFB_RS06155	COG0460	homoserine dehydrogenase
XFFB_RS06160	COG0540	Belongs to the ATCase OTCase family
XFFB_RS06170	COG1678	Uncharacterized ACR, COG1678
XFFB_RS06180	COG1686	Belongs to the peptidase S11 family
XFFB_RS06190	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
XFFB_RS06205	COG4953	penicillin-binding protein 1C
XFFB_RS06235	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
XFFB_RS06240	COG0481	GTPase activity
XFFB_RS06255	COG0571	ribonuclease III activity
XFFB_RS06260	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
XFFB_RS06265	COG1381	Involved in DNA repair and RecF pathway recombination
XFFB_RS06270	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
XFFB_RS06275	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
XFFB_RS06285	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
XFFB_RS06290	COG1971	Probably functions as a manganese efflux pump
XFFB_RS06300	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XFFB_RS06305	COG0823	Involved in the tonB-independent uptake of proteins
XFFB_RS06305	COG1506	peptidase
XFFB_RS06310	COG1297	OPT oligopeptide transporter protein
XFFB_RS06330	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
XFFB_RS06340	COG0676	glucose-6-phosphate 1-epimerase activity
XFFB_RS06350	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
XFFB_RS06355	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
XFFB_RS06365	COG0318	PFAM AMP-dependent synthetase and ligase
XFFB_RS06375	COG0463	Glycosyl transferase, family 2
XFFB_RS06385	COG1475	DNA binding
XFFB_RS06390	COG1192	Involved in chromosome partitioning
XFFB_RS06400	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
XFFB_RS06455	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
XFFB_RS06460	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
XFFB_RS06465	COG0489	protein tyrosine kinase activity
XFFB_RS06470	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
XFFB_RS06515	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
XFFB_RS06520	COG0322	excinuclease ABC activity
XFFB_RS06535	COG3772	lysozyme
XFFB_RS06575	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
XFFB_RS06580	COG0077	Prephenate dehydratase
XFFB_RS06580	COG1605	Chorismate mutase
XFFB_RS06585	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
XFFB_RS06595	COG1668	transmembrane transport
XFFB_RS06600	COG4555	ABC transporter
XFFB_RS06615	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
XFFB_RS06620	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
XFFB_RS06625	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
XFFB_RS06645	COG0287	Prephenate dehydrogenase
XFFB_RS06645	COG1605	Chorismate mutase
XFFB_RS06650	COG0484	heat shock protein binding
XFFB_RS06655	COG0443	Heat shock 70 kDa protein
XFFB_RS06660	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
XFFB_RS06670	COG0497	DNA recombination
XFFB_RS06680	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XFFB_RS06685	COG2914	Belongs to the UPF0125 (RnfH) family
XFFB_RS06695	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
XFFB_RS06705	COG1278	Cold shock
XFFB_RS06710	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
XFFB_RS06715	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
XFFB_RS06725	COG2954	triphosphatase activity
XFFB_RS06730	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
XFFB_RS06735	COG0745	RESPONSE REGULATOR receiver
XFFB_RS06740	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
XFFB_RS06745	COG0438	transferase activity, transferring glycosyl groups
XFFB_RS06760	COG0438	transferase activity, transferring glycosyl groups
XFFB_RS06790	COG0473	3-isopropylmalate dehydrogenase activity
XFFB_RS06795	COG0066	3-isopropylmalate dehydratase activity
XFFB_RS06800	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
XFFB_RS06820	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
XFFB_RS06820	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
XFFB_RS06825	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XFFB_RS06830	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XFFB_RS06845	COG1064	alcohol dehydrogenase
XFFB_RS06865	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
XFFB_RS06925	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
XFFB_RS06925	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XFFB_RS06960	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
XFFB_RS06970	COG0196	riboflavin kinase activity
XFFB_RS06975	COG0728	peptidoglycan biosynthetic process
XFFB_RS06980	COG0268	Binds directly to 16S ribosomal RNA
XFFB_RS06985	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
XFFB_RS06990	COG0211	Belongs to the bacterial ribosomal protein bL27 family
XFFB_RS06995	COG0261	This protein binds to 23S rRNA in the presence of protein L20
XFFB_RS07015	COG0519	Catalyzes the synthesis of GMP from XMP
XFFB_RS07015	COG0518	GMP synthase (glutamine-hydrolyzing) activity
XFFB_RS07025	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
XFFB_RS07030	COG1210	Utp--glucose-1-phosphate uridylyltransferase
XFFB_RS07045	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
XFFB_RS07055	COG0776	regulation of translation
XFFB_RS07065	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
XFFB_RS07100	COG0395	ABC-type sugar transport system, permease component
XFFB_RS07105	COG1175	transmembrane transport
XFFB_RS07130	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
XFFB_RS07135	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
XFFB_RS07140	COG1187	pseudouridine synthase activity
XFFB_RS07155	COG0436	Aminotransferase
XFFB_RS07160	COG4133	protoheme IX ABC transporter activity
XFFB_RS07180	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
XFFB_RS07185	COG1138	Cytochrome C-type biogenesis protein
XFFB_RS07190	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
XFFB_RS07230	COG0546	phosphoglycolate phosphatase activity
XFFB_RS07235	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
XFFB_RS07240	COG0402	S-adenosylhomocysteine deaminase activity
XFFB_RS07250	COG1509	lysine 2,3-aminomutase activity
XFFB_RS07260	COG0483	inositol monophosphate 1-phosphatase activity
XFFB_RS07265	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
XFFB_RS07290	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
XFFB_RS07295	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
XFFB_RS07310	COG1028	Short-chain dehydrogenase reductase Sdr
XFFB_RS07365	COG0142	geranyltranstransferase activity
XFFB_RS07370	COG1722	exodeoxyribonuclease VII activity
XFFB_RS07375	COG0037	tRNA processing
XFFB_RS07385	COG1301	dicarboxylic acid transport
XFFB_RS07395	COG0791	NLP P60 protein
XFFB_RS07400	COG0791	NLP P60 protein
XFFB_RS07410	COG2311	Membrane
XFFB_RS07425	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
XFFB_RS07530	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
XFFB_RS07540	COG0351	phosphomethylpyrimidine kinase
XFFB_RS07540	COG0352	thiamine-phosphate diphosphorylase activity
XFFB_RS07550	COG1324	tolerance protein
XFFB_RS07585	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
XFFB_RS07595	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
XFFB_RS07610	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
XFFB_RS07630	COG4774	siderophore transport
XFFB_RS07635	COG3128	pkhd-type hydroxylase
XFFB_RS07655	COG1477	protein flavinylation
XFFB_RS07660	COG1555	photosystem II stabilization
XFFB_RS07665	COG3178	'Phosphotransferase
XFFB_RS07670	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
XFFB_RS07680	COG0628	permease
XFFB_RS07690	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
XFFB_RS07700	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
XFFB_RS07730	COG3590	peptidase
XFFB_RS07750	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
XFFB_RS07760	COG0037	tRNA processing
XFFB_RS07765	COG2974	May be involved in recombination
XFFB_RS07775	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
XFFB_RS07785	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
XFFB_RS07805	COG0519	Catalyzes the synthesis of GMP from XMP
XFFB_RS07805	COG0518	GMP synthase (glutamine-hydrolyzing) activity
XFFB_RS07820	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
XFFB_RS07825	COG1162	GTPase activity
XFFB_RS07830	COG0792	nuclease activity
XFFB_RS07835	COG3107	peptidoglycan biosynthetic process
XFFB_RS07840	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
XFFB_RS07850	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
XFFB_RS07850	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
XFFB_RS07855	COG2878	Part of a membrane complex involved in electron transport
XFFB_RS07960	COG5449	Phage conserved hypothetical protein BR0599
XFFB_RS08005	COG3772	lysozyme
XFFB_RS08115	COG4969	Belongs to the N-Me-Phe pilin family
XFFB_RS08140	COG0629	single-stranded DNA binding
XFFB_RS08185	COG4968	Prepilin-type N-terminal cleavage methylation domain
XFFB_RS08195	COG4943	cyclic-guanylate-specific phosphodiesterase activity
XFFB_RS08210	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
XFFB_RS08215	COG1160	GTP binding
XFFB_RS08220	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XFFB_RS08240	COG0820	rRNA (adenine-C2-)-methyltransferase activity
XFFB_RS08245	COG0105	UTP biosynthetic process
XFFB_RS08250	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
XFFB_RS08255	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
XFFB_RS08265	COG0330	HflC and HflK could
XFFB_RS08270	COG0330	HflC and HflK could
XFFB_RS08275	COG0604	alcohol dehydrogenase
XFFB_RS08300	COG0442	prolyl-tRNA aminoacylation
XFFB_RS08310	COG1183	phosphatidylcholine synthase activity
XFFB_RS08330	COG0668	transmembrane transport
XFFB_RS08335	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
XFFB_RS08340	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
XFFB_RS08350	COG1610	YqeY-like protein
XFFB_RS08360	COG0358	DNA primase activity
XFFB_RS08365	COG0180	Tryptophanyl-tRNA synthetase
XFFB_RS08380	COG1074	ATP-dependent DNA helicase activity
XFFB_RS08390	COG1127	ABC transporter
XFFB_RS08395	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
XFFB_RS08400	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
XFFB_RS08415	COG2853	Lipoprotein
XFFB_RS08425	COG1322	Protein conserved in bacteria
XFFB_RS08430	COG1116	anion transmembrane transporter activity
XFFB_RS08440	COG0531	amino acid
XFFB_RS08445	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
XFFB_RS08450	COG0861	Integral membrane protein TerC family
XFFB_RS08485	COG2205	protein histidine kinase activity
XFFB_RS08485	COG3437	response regulator, receiver
XFFB_RS08485	COG3850	Histidine kinase
XFFB_RS08485	COG4999	Histidine kinase
XFFB_RS08500	COG2193	ferroxidase activity
XFFB_RS08510	COG0494	nUDIX hydrolase
XFFB_RS08525	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
XFFB_RS08570	COG0542	response to heat
XFFB_RS08580	COG0352	thiamine-phosphate diphosphorylase activity
XFFB_RS08585	COG2124	cytochrome p450
XFFB_RS08590	COG2194	sulfuric ester hydrolase activity
XFFB_RS08625	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
XFFB_RS08630	COG0667	Aldo Keto reductase
XFFB_RS08635	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
XFFB_RS08650	COG0305	Participates in initiation and elongation during chromosome replication
XFFB_RS08665	COG2124	cytochrome p450
XFFB_RS08670	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
XFFB_RS08680	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
XFFB_RS08685	COG0277	FAD linked oxidase domain protein
XFFB_RS08705	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
XFFB_RS08710	COG4206	TonB-dependent receptor
XFFB_RS08715	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
XFFB_RS08750	COG0675	Transposase, IS605 OrfB family
XFFB_RS08770	COG0642	Histidine kinase
XFFB_RS08785	COG2851	Citrate transporter
XFFB_RS08790	COG1028	Short-chain dehydrogenase reductase Sdr
XFFB_RS08795	COG1007	ATP synthesis coupled electron transport
XFFB_RS08810	COG0713	ATP synthesis coupled electron transport
XFFB_RS08830	COG1034	ATP synthesis coupled electron transport
XFFB_RS08835	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
XFFB_RS08840	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
XFFB_RS08850	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XFFB_RS08860	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XFFB_RS08930	COG1049	propionate catabolic process, 2-methylcitrate cycle
XFFB_RS08960	COG1090	epimerase
XFFB_RS08965	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
XFFB_RS08985	COG0628	permease
XFFB_RS08990	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
XFFB_RS09000	COG0671	phosphoesterase, PA-phosphatase related
XFFB_RS09005	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
XFFB_RS09010	COG0563	adenylate kinase activity
XFFB_RS09025	COG0477	Major facilitator Superfamily
XFFB_RS09040	COG1946	Acyl-CoA thioesterase
XFFB_RS09050	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
XFFB_RS09060	COG1914	H( )-stimulated, divalent metal cation uptake system
XFFB_RS09115	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
XFFB_RS09120	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
XFFB_RS09125	COG0165	Argininosuccinate lyase
XFFB_RS09135	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
XFFB_RS09140	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
XFFB_RS09145	COG0137	argininosuccinate synthase activity
XFFB_RS09150	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
XFFB_RS09165	COG0215	cysteine-tRNA ligase activity
XFFB_RS09170	COG2166	iron-sulfur cluster assembly
XFFB_RS09190	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
XFFB_RS09195	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
XFFB_RS09215	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
XFFB_RS09225	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
XFFB_RS09230	COG0742	ribosomal rna small subunit methyltransferase
XFFB_RS09235	COG0326	Molecular chaperone. Has ATPase activity
XFFB_RS09240	COG0281	malic enzyme
XFFB_RS09240	COG0280	phosphate acetyltransferase
XFFB_RS09245	COG1301	dicarboxylic acid transport
XFFB_RS09415	COG2369	cell adhesion
XFFB_RS09475	COG0582	viral genome integration into host DNA
XFFB_RS09485	COG5410	chromosome segregation
XFFB_RS09510	COG3772	lysozyme
XFFB_RS09530	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
XFFB_RS09645	COG5532	Uncharacterized conserved protein (DUF2303)
XFFB_RS09665	COG0629	single-stranded DNA binding
XFFB_RS09675	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
XFFB_RS09695	COG0745	RESPONSE REGULATOR receiver
XFFB_RS09700	COG0642	Histidine kinase
XFFB_RS09710	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
XFFB_RS09755	COG0045	succinate-CoA ligase (ADP-forming) activity
XFFB_RS09760	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
XFFB_RS09770	COG2831	hemolysin activation secretion protein
XFFB_RS09785	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
XFFB_RS09795	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
XFFB_RS09805	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
XFFB_RS09810	COG3115	cell septum assembly
XFFB_RS09820	COG0359	binds to the 23S rRNA
XFFB_RS09825	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
XFFB_RS09835	COG0316	Belongs to the HesB IscA family
XFFB_RS09840	COG0017	Asparaginyl-tRNA synthetase
XFFB_RS09865	COG0167	dihydroorotate dehydrogenase activity
XFFB_RS09870	COG0812	UDP-N-acetylmuramate dehydrogenase activity
XFFB_RS09875	COG0697	spore germination
XFFB_RS09885	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
XFFB_RS09900	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
XFFB_RS09905	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
XFFB_RS09920	COG1132	(ABC) transporter
XFFB_RS09930	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
XFFB_RS09935	COG1538	Outer membrane efflux protein
XFFB_RS09940	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XFFB_RS09955	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
XFFB_RS09970	COG4783	chaperone-mediated protein folding
XFFB_RS09980	COG0473	3-isopropylmalate dehydrogenase activity
XFFB_RS09990	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
XFFB_RS10000	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
XFFB_RS10010	COG0316	Belongs to the HesB IscA family
XFFB_RS10010	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
XFFB_RS10015	COG2154	pterin-4-alpha-carbinolamine dehydratase
XFFB_RS10025	COG0564	pseudouridine synthase activity
XFFB_RS10035	COG2197	response regulator
XFFB_RS10040	COG1054	Belongs to the UPF0176 family
XFFB_RS10055	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
XFFB_RS10070	COG0488	(ABC) transporter
XFFB_RS10080	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
XFFB_RS10085	COG1278	Cold shock
XFFB_RS10095	COG0501	Belongs to the peptidase M48B family
XFFB_RS10105	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
XFFB_RS10110	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
XFFB_RS10115	COG0049	tRNA binding
XFFB_RS10125	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
XFFB_RS10130	COG0085	RNA polymerase activity
XFFB_RS10135	COG0222	ribosome binding
XFFB_RS10140	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
XFFB_RS10145	COG0081	regulation of translation
XFFB_RS10150	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
XFFB_RS10155	COG0250	Participates in transcription elongation, termination and antitermination
XFFB_RS10160	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
XFFB_RS10170	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
XFFB_RS10190	COG0012	GTP binding
XFFB_RS10195	COG0193	aminoacyl-tRNA hydrolase activity
XFFB_RS10205	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
XFFB_RS10215	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
XFFB_RS10220	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
XFFB_RS10230	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
XFFB_RS10235	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
XFFB_RS10245	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
XFFB_RS10245	COG0116	Belongs to the methyltransferase superfamily
XFFB_RS10295	COG2095	MarC family integral membrane protein
XFFB_RS10305	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
XFFB_RS10320	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
XFFB_RS10345	COG0210	DNA helicase
XFFB_RS10350	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
XFFB_RS10355	COG0616	signal peptide processing
XFFB_RS10360	COG0534	Mate efflux family protein
XFFB_RS10375	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
XFFB_RS10385	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
XFFB_RS10390	COG2201	protein-glutamate methylesterase activity
XFFB_RS10395	COG2177	Part of the ABC transporter FtsEX involved in
XFFB_RS10400	COG2884	Cell division ATP-binding protein ftsE
XFFB_RS10405	COG0513	Belongs to the DEAD box helicase family
XFFB_RS10410	COG3118	belongs to the thioredoxin family
XFFB_RS10415	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
XFFB_RS10430	COG0793	Belongs to the peptidase S41A family
XFFB_RS10435	COG4942	peptidase
XFFB_RS10450	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XFFB_RS10455	COG0493	'glutamate synthase
XFFB_RS10460	COG0069	glutamate synthase activity
XFFB_RS10460	COG0067	glutamate synthase
XFFB_RS10460	COG0070	glutamate synthase
XFFB_RS10495	COG1028	Short-chain dehydrogenase reductase Sdr
XFFB_RS10520	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
XFFB_RS10545	COG0732	type I restriction modification DNA specificity domain
XFFB_RS10565	COG1280	lysine exporter protein (LysE YggA)
XFFB_RS10580	COG4942	peptidase
XFFB_RS10610	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
XFFB_RS10625	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
XFFB_RS10775	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
XFFB_RS10780	COG3657	addiction module killer protein
XFFB_RS10800	COG1131	(ABC) transporter
XFFB_RS10805	COG0386	Belongs to the glutathione peroxidase family
XFFB_RS10820	COG2900	Belongs to the SlyX family
XFFB_RS10835	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
XFFB_RS10845	COG2027	D-alanyl-D-alanine carboxypeptidase
XFFB_RS10860	COG2226	methyltransferase
XFFB_RS10875	COG2943	transferase activity, transferring hexosyl groups
XFFB_RS10885	COG3275	phosphorelay sensor kinase activity
XFFB_RS10895	COG0181	hydroxymethylbilane synthase activity
XFFB_RS10940	COG0463	Glycosyl transferase, family 2
XFFB_RS10950	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
XFFB_RS10965	COG0392	lysyltransferase activity
XFFB_RS10965	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
XFFB_RS10970	COG0251	oxidation-reduction process
XFFB_RS10985	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
XFFB_RS10990	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
XFFB_RS10995	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
XFFB_RS11000	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
XFFB_RS11010	COG0582	viral genome integration into host DNA
XFFB_RS11020	COG1396	sequence-specific DNA binding
XFFB_RS11030	COG0583	DNA-binding transcription factor activity
XFFB_RS11035	COG0667	Aldo Keto reductase
XFFB_RS11040	COG0667	Aldo Keto reductase
XFFB_RS11045	COG1942	4-Oxalocrotonate Tautomerase
XFFB_RS11065	COG0667	Aldo Keto reductase
XFFB_RS11070	COG0583	DNA-binding transcription factor activity
XFFB_RS11075	COG1902	pentaerythritol trinitrate reductase activity
XFFB_RS11085	COG1064	alcohol dehydrogenase
XFFB_RS11115	COG2133	pyrroloquinoline quinone binding
XFFB_RS11120	COG1028	Short-chain dehydrogenase reductase Sdr
XFFB_RS11125	COG3386	PFAM SMP-30 Gluconolaconase
XFFB_RS11135	COG4221	oxidoreductase activity
XFFB_RS11145	COG1064	alcohol dehydrogenase
XFFB_RS11320	COG0270	DNA (cytosine-5-)-methyltransferase activity
XFFB_RS11330	COG0629	single-stranded DNA binding
XFFB_RS11415	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
XFFB_RS11420	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
XFFB_RS11420	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
XFFB_RS11445	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
XFFB_RS11465	COG0338	D12 class N6 adenine-specific DNA methyltransferase
XFFB_RS11485	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
XFFB_RS11490	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
XFFB_RS11495	COG0537	adenosine 5'-monophosphoramidase activity
XFFB_RS11515	COG0714	Associated with various cellular activities
XFFB_RS11525	COG1399	metal-binding, possibly nucleic acid-binding protein
XFFB_RS11530	COG0333	Belongs to the bacterial ribosomal protein bL32 family
XFFB_RS11535	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
XFFB_RS11540	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
XFFB_RS11560	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
XFFB_RS11570	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
XFFB_RS11575	COG1764	response to oxidative stress
XFFB_RS11580	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
XFFB_RS11605	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
XFFB_RS11615	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
XFFB_RS11630	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
XFFB_RS11775	COG3772	lysozyme
XFFB_RS11845	COG2944	sequence-specific DNA binding
XFFB_RS11915	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
XFFB_RS11920	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
XFFB_RS11930	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
XFFB_RS11935	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
XFFB_RS11940	COG0072	phenylalanine-tRNA ligase activity
XFFB_RS11940	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
XFFB_RS11945	COG0776	regulation of translation
XFFB_RS11965	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
XFFB_RS11990	COG1570	exodeoxyribonuclease VII activity
XFFB_RS12000	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
XFFB_RS12000	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
XFFB_RS12005	COG0802	atpase or kinase
XFFB_RS12010	COG0860	N-Acetylmuramoyl-L-alanine amidase
XFFB_RS12015	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
XFFB_RS12025	COG0717	Belongs to the dCTP deaminase family
XFFB_RS12030	COG0730	response to heat
XFFB_RS12035	COG2391	methyltransferase activity
XFFB_RS12040	COG2391	methyltransferase activity
XFFB_RS12045	COG0640	Transcriptional regulator
XFFB_RS12050	COG3453	Protein conserved in bacteria
XFFB_RS12050	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
XFFB_RS12075	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
XFFB_RS12100	COG2755	lipolytic protein G-D-S-L family
XFFB_RS12100	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
XFFB_RS12130	COG2022	thiamine diphosphate biosynthetic process
XFFB_RS12135	COG0220	tRNA (guanine-N7-)-methyltransferase activity
XFFB_RS12140	COG3273	potassium ion transport
XFFB_RS12140	COG0471	metal ion transport
XFFB_RS12155	COG2001	Belongs to the MraZ family
XFFB_RS12160	COG0275	rRNA processing
XFFB_RS12165	COG3116	cell division
XFFB_RS12175	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
XFFB_RS12180	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
XFFB_RS12185	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
XFFB_RS12195	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
XFFB_RS12200	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
XFFB_RS12205	COG1181	Belongs to the D-alanine--D-alanine ligase family
XFFB_RS12210	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
XFFB_RS12220	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
XFFB_RS12230	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
XFFB_RS12240	COG0739	heme binding
XFFB_RS12245	COG0653	protein targeting
XFFB_RS12250	COG4305	rare lipoprotein A
XFFB_RS12265	COG0612	Peptidase, M16
XFFB_RS12275	COG5297	Belongs to the glycosyl hydrolase family 6
XFFB_RS12275	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XFFB_RS12285	COG0735	belongs to the Fur family
XFFB_RS12290	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
XFFB_RS12295	COG0126	phosphoglycerate kinase activity
XFFB_RS12305	COG0469	pyruvate kinase activity
XFFB_RS12315	COG3588	fructose-bisphosphate aldolase
XFFB_RS12345	COG0583	DNA-binding transcription factor activity
XFFB_RS12350	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XFFB_RS12355	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XFFB_RS12365	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
XFFB_RS12370	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
XFFB_RS12375	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
XFFB_RS12385	COG3537	Alpha-1,2-mannosidase
XFFB_RS12400	COG1472	Belongs to the glycosyl hydrolase 3 family
XFFB_RS12410	COG3525	Glycosyl hydrolase, family 20, catalytic domain
XFFB_RS12415	COG1388	LysM domain
XFFB_RS12415	COG3858	chitin binding
XFFB_RS12420	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
XFFB_RS12425	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XFFB_RS12430	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
XFFB_RS12440	COG5002	protein histidine kinase activity
XFFB_RS12455	COG1238	metal cluster binding
XFFB_RS12460	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
XFFB_RS12465	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
XFFB_RS12485	COG0739	heme binding
XFFB_RS12490	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
XFFB_RS12495	COG0626	cystathionine gamma-synthase activity
XFFB_RS12510	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
XFFB_RS12515	COG0508	dehydrogenase complex catalyzes the overall conversion of
XFFB_RS12530	COG1464	Belongs to the NlpA lipoprotein family
XFFB_RS12535	COG2011	ABC-type metal ion transport system permease component
XFFB_RS12540	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
XFFB_RS12565	COG0288	reversible hydration of carbon dioxide
XFFB_RS12575	COG1199	ATP-dependent helicase activity
XFFB_RS12585	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
XFFB_RS12690	COG2951	lytic endotransglycosylase activity
XFFB_RS12720	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
XFFB_RS12735	COG0495	leucyl-tRNA aminoacylation
XFFB_RS12745	COG3118	belongs to the thioredoxin family
XFFB_RS12755	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
XFFB_RS12770	COG2183	response to ionizing radiation
XFFB_RS12785	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
XFFB_RS12795	COG0328	RNA-DNA hybrid ribonuclease activity
XFFB_RS12800	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
XFFB_RS12805	COG0631	protein serine/threonine phosphatase activity
XFFB_RS12820	COG0859	PFAM glycosyl transferase family 9
XFFB_RS12825	COG3642	lipopolysaccharide core region biosynthetic process
XFFB_RS12840	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
XFFB_RS12845	COG2967	ApaG domain
XFFB_RS12850	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
XFFB_RS12855	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
XFFB_RS12860	COG0704	Plays a role in the regulation of phosphate uptake
XFFB_RS12865	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
XFFB_RS12870	COG0581	inorganic phosphate transmembrane transporter activity
XFFB_RS12875	COG0573	inorganic phosphate transmembrane transporter activity
XFFB_RS12880	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
XFFB_RS12885	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
XFFB_RS12885	COG4651	solute:proton antiporter activity
XFFB_RS12900	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
XFFB_RS12910	COG0488	(ABC) transporter
XFFB_RS13045	COG3772	lysozyme
XFFB_RS13070	COG5410	chromosome segregation
XFFB_RS13075	COG3567	Phage-associated protein, HI1409 family
XFFB_RS13080	COG2369	cell adhesion
XFFB_RS13145	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
XFFB_RS13150	COG3657	addiction module killer protein
XFFB_RS13205	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
XFFB_RS13215	COG0706	membrane insertase activity
XFFB_RS13220	COG0594	ribonuclease P activity
XFFB_RS13235	COG3451	type IV secretory pathway VirB4
XFFB_RS13295	COG0596	Alpha beta hydrolase
XFFB_RS13340	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
XFFB_RS13455	COG0629	single-stranded DNA binding
XFFB_RS13465	COG4962	Type ii secretion system protein e