locus-tag	class	description
XFC3_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
XFC3_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
XFC3_RS00025	COG0187	DNA topoisomerase II activity
XFC3_RS00035	COG0501	Belongs to the peptidase M48B family
XFC3_RS00075	COG0408	coproporphyrinogen oxidase activity
XFC3_RS00105	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
XFC3_RS00120	COG4969	Belongs to the N-Me-Phe pilin family
XFC3_RS00150	COG0284	orotidine-5'-phosphate decarboxylase activity
XFC3_RS00190	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
XFC3_RS00200	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
XFC3_RS00210	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
XFC3_RS00215	COG0511	ligase activity, forming carbon-carbon bonds
XFC3_RS00220	COG0439	Biotin carboxylase
XFC3_RS00225	COG0210	DNA helicase
XFC3_RS00235	COG1017	nitric oxide dioxygenase activity
XFC3_RS00235	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
XFC3_RS00250	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
XFC3_RS00260	COG1040	competence protein
XFC3_RS00265	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
XFC3_RS00270	COG1752	Esterase of the alpha-beta hydrolase superfamily
XFC3_RS00280	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
XFC3_RS00315	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
XFC3_RS00325	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
XFC3_RS00355	COG3121	Chaperone
XFC3_RS00360	COG3539	Fimbrial protein
XFC3_RS00365	COG1546	Belongs to the CinA family
XFC3_RS00370	COG0477	Major facilitator Superfamily
XFC3_RS00375	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
XFC3_RS00380	COG1923	regulation of RNA biosynthetic process
XFC3_RS00385	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
XFC3_RS00390	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
XFC3_RS00400	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
XFC3_RS00410	COG1534	Rna-binding protein
XFC3_RS00420	COG0129	dihydroxy-acid dehydratase activity
XFC3_RS00445	COG1560	Kdo2-lipid A biosynthetic process
XFC3_RS00450	COG1519	Transferase
XFC3_RS00460	COG0228	four-way junction DNA binding
XFC3_RS00465	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
XFC3_RS00470	COG0336	Belongs to the RNA methyltransferase TrmD family
XFC3_RS00475	COG0335	large ribosomal subunit rRNA binding
XFC3_RS00495	COG2171	N-acyltransferase activity
XFC3_RS00500	COG1393	Belongs to the ArsC family
XFC3_RS00505	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
XFC3_RS00510	COG0367	asparagine synthase
XFC3_RS00520	COG2070	2-Nitropropane dioxygenase
XFC3_RS00525	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
XFC3_RS00530	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
XFC3_RS00550	COG0339	signal peptide processing
XFC3_RS00565	COG2132	Multicopper oxidase
XFC3_RS00575	COG0525	valine-tRNA ligase activity
XFC3_RS00615	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
XFC3_RS00625	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
XFC3_RS00630	COG1166	arginine decarboxylase activity
XFC3_RS00635	COG4221	oxidoreductase activity
XFC3_RS00645	COG0018	arginyl-trna synthetase
XFC3_RS00650	COG2003	Belongs to the UPF0758 family
XFC3_RS00655	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
XFC3_RS00665	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
XFC3_RS00675	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
XFC3_RS00720	COG2223	nitrite transmembrane transporter activity
XFC3_RS00725	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
XFC3_RS00730	COG0739	heme binding
XFC3_RS00735	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
XFC3_RS00765	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
XFC3_RS00780	COG1028	Short-chain dehydrogenase reductase Sdr
XFC3_RS00785	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
XFC3_RS00790	COG1272	protein, Hemolysin III
XFC3_RS00795	COG0463	Glycosyl transferase, family 2
XFC3_RS00800	COG0084	hydrolase, TatD family'
XFC3_RS00815	COG0509	glycine decarboxylation via glycine cleavage system
XFC3_RS00820	COG0404	The glycine cleavage system catalyzes the degradation of glycine
XFC3_RS00830	COG0330	HflC and HflK could
XFC3_RS00835	COG3956	TIGRFAM MazG family protein
XFC3_RS00840	COG1218	3'(2'),5'-bisphosphate nucleotidase
XFC3_RS00845	COG0494	nUDIX hydrolase
XFC3_RS00855	COG1385	rRNA (uridine-N3-)-methyltransferase activity
XFC3_RS00865	COG0513	Belongs to the DEAD box helicase family
XFC3_RS00870	COG0720	synthase
XFC3_RS00905	COG1981	membrane
XFC3_RS00910	COG0825	malonyl-CoA metabolic process
XFC3_RS00915	COG0587	DNA-directed DNA polymerase activity
XFC3_RS00945	COG0512	Glutamine amidotransferase of anthranilate synthase
XFC3_RS00950	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
XFC3_RS00955	COG0134	indole-3-glycerol-phosphate synthase activity
XFC3_RS00980	COG0006	proline dipeptidase activity
XFC3_RS00995	COG0343	queuine tRNA-ribosyltransferase activity
XFC3_RS01000	COG1862	Preprotein translocase
XFC3_RS01005	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
XFC3_RS01010	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
XFC3_RS01020	COG0617	tRNA 3'-terminal CCA addition
XFC3_RS01030	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
XFC3_RS01035	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
XFC3_RS01040	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
XFC3_RS01045	COG0166	Belongs to the GPI family
XFC3_RS01060	COG0779	Required for maturation of 30S ribosomal subunits
XFC3_RS01065	COG0195	Participates in both transcription termination and antitermination
XFC3_RS01070	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
XFC3_RS01075	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
XFC3_RS01080	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
XFC3_RS01090	COG1185	polyribonucleotide nucleotidyltransferase activity
XFC3_RS01095	COG1733	regulation of RNA biosynthetic process
XFC3_RS01100	COG0702	epimerase
XFC3_RS01155	COG2086	electron transfer activity
XFC3_RS01185	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
XFC3_RS01215	COG0477	Major facilitator Superfamily
XFC3_RS01230	COG0563	adenylate kinase activity
XFC3_RS01235	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
XFC3_RS01240	COG0671	phosphoesterase, PA-phosphatase related
XFC3_RS01250	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
XFC3_RS01255	COG0628	permease
XFC3_RS01275	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
XFC3_RS01280	COG1090	epimerase
XFC3_RS01285	COG0318	PFAM AMP-dependent synthetase and ligase
XFC3_RS01310	COG1049	propionate catabolic process, 2-methylcitrate cycle
XFC3_RS01380	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XFC3_RS01390	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XFC3_RS01400	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
XFC3_RS01405	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
XFC3_RS01410	COG1034	ATP synthesis coupled electron transport
XFC3_RS01430	COG0713	ATP synthesis coupled electron transport
XFC3_RS01445	COG1007	ATP synthesis coupled electron transport
XFC3_RS01450	COG1028	Short-chain dehydrogenase reductase Sdr
XFC3_RS01455	COG2851	Citrate transporter
XFC3_RS01470	COG0642	Histidine kinase
XFC3_RS01490	COG0675	Transposase, IS605 OrfB family
XFC3_RS01530	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
XFC3_RS01535	COG4206	TonB-dependent receptor
XFC3_RS01540	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
XFC3_RS01560	COG0277	FAD linked oxidase domain protein
XFC3_RS01565	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
XFC3_RS01575	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
XFC3_RS01580	COG2124	cytochrome p450
XFC3_RS01595	COG0305	Participates in initiation and elongation during chromosome replication
XFC3_RS01610	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
XFC3_RS01615	COG0667	Aldo Keto reductase
XFC3_RS01620	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
XFC3_RS01655	COG2194	sulfuric ester hydrolase activity
XFC3_RS01660	COG2124	cytochrome p450
XFC3_RS01665	COG0352	thiamine-phosphate diphosphorylase activity
XFC3_RS01675	COG0542	response to heat
XFC3_RS01695	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
XFC3_RS01720	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
XFC3_RS01735	COG0494	nUDIX hydrolase
XFC3_RS01745	COG2193	ferroxidase activity
XFC3_RS01795	COG0861	Integral membrane protein TerC family
XFC3_RS01800	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
XFC3_RS01805	COG0531	amino acid
XFC3_RS01815	COG1116	anion transmembrane transporter activity
XFC3_RS01820	COG1322	Protein conserved in bacteria
XFC3_RS01830	COG2853	Lipoprotein
XFC3_RS01845	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
XFC3_RS01850	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
XFC3_RS01855	COG1127	ABC transporter
XFC3_RS01860	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
XFC3_RS01865	COG1074	ATP-dependent DNA helicase activity
XFC3_RS01885	COG0180	Tryptophanyl-tRNA synthetase
XFC3_RS01890	COG0358	DNA primase activity
XFC3_RS01900	COG1610	YqeY-like protein
XFC3_RS01910	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
XFC3_RS01915	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
XFC3_RS01920	COG0668	transmembrane transport
XFC3_RS01940	COG1183	phosphatidylcholine synthase activity
XFC3_RS01950	COG0442	prolyl-tRNA aminoacylation
XFC3_RS01970	COG0604	alcohol dehydrogenase
XFC3_RS01975	COG0330	HflC and HflK could
XFC3_RS01980	COG0330	HflC and HflK could
XFC3_RS01990	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
XFC3_RS01995	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
XFC3_RS02000	COG0105	UTP biosynthetic process
XFC3_RS02005	COG0820	rRNA (adenine-C2-)-methyltransferase activity
XFC3_RS02025	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XFC3_RS02030	COG1160	GTP binding
XFC3_RS02035	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
XFC3_RS02050	COG4943	cyclic-guanylate-specific phosphodiesterase activity
XFC3_RS02055	COG1611	Belongs to the LOG family
XFC3_RS02060	COG4968	Prepilin-type N-terminal cleavage methylation domain
XFC3_RS02155	COG2878	Part of a membrane complex involved in electron transport
XFC3_RS02160	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
XFC3_RS02160	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
XFC3_RS02170	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
XFC3_RS02175	COG3107	peptidoglycan biosynthetic process
XFC3_RS02180	COG0792	nuclease activity
XFC3_RS02185	COG1162	GTPase activity
XFC3_RS02190	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
XFC3_RS02205	COG0519	Catalyzes the synthesis of GMP from XMP
XFC3_RS02205	COG0518	GMP synthase (glutamine-hydrolyzing) activity
XFC3_RS02220	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
XFC3_RS02225	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
XFC3_RS02235	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
XFC3_RS02250	COG0037	tRNA processing
XFC3_RS02260	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
XFC3_RS02285	COG3590	peptidase
XFC3_RS02315	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
XFC3_RS02325	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
XFC3_RS02335	COG0628	permease
XFC3_RS02345	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
XFC3_RS02350	COG3178	'Phosphotransferase
XFC3_RS02355	COG1555	photosystem II stabilization
XFC3_RS02360	COG1477	protein flavinylation
XFC3_RS02380	COG3128	pkhd-type hydroxylase
XFC3_RS02385	COG4774	siderophore transport
XFC3_RS02405	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
XFC3_RS02420	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
XFC3_RS02430	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
XFC3_RS02455	COG0459	protein refolding
XFC3_RS02465	COG1324	tolerance protein
XFC3_RS02475	COG0352	thiamine-phosphate diphosphorylase activity
XFC3_RS02475	COG0351	phosphomethylpyrimidine kinase
XFC3_RS02485	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
XFC3_RS02590	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
XFC3_RS02605	COG2311	Membrane
XFC3_RS02615	COG0791	NLP P60 protein
XFC3_RS02620	COG0791	NLP P60 protein
XFC3_RS02630	COG1301	dicarboxylic acid transport
XFC3_RS02640	COG0037	tRNA processing
XFC3_RS02645	COG1722	exodeoxyribonuclease VII activity
XFC3_RS02650	COG0142	geranyltranstransferase activity
XFC3_RS02705	COG1028	Short-chain dehydrogenase reductase Sdr
XFC3_RS02720	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
XFC3_RS02725	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
XFC3_RS02750	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
XFC3_RS02755	COG0483	inositol monophosphate 1-phosphatase activity
XFC3_RS02765	COG1509	lysine 2,3-aminomutase activity
XFC3_RS02775	COG0402	S-adenosylhomocysteine deaminase activity
XFC3_RS02780	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
XFC3_RS02785	COG0546	phosphoglycolate phosphatase activity
XFC3_RS02825	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
XFC3_RS02835	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
XFC3_RS02855	COG4133	protoheme IX ABC transporter activity
XFC3_RS02860	COG0436	Aminotransferase
XFC3_RS02875	COG1187	pseudouridine synthase activity
XFC3_RS02880	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
XFC3_RS02885	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
XFC3_RS02910	COG1175	transmembrane transport
XFC3_RS02915	COG0395	ABC-type sugar transport system, permease component
XFC3_RS02950	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
XFC3_RS02960	COG0776	regulation of translation
XFC3_RS02970	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
XFC3_RS02985	COG1210	Utp--glucose-1-phosphate uridylyltransferase
XFC3_RS02990	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
XFC3_RS03000	COG0518	GMP synthase (glutamine-hydrolyzing) activity
XFC3_RS03000	COG0519	Catalyzes the synthesis of GMP from XMP
XFC3_RS03015	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
XFC3_RS03020	COG0261	This protein binds to 23S rRNA in the presence of protein L20
XFC3_RS03025	COG0211	Belongs to the bacterial ribosomal protein bL27 family
XFC3_RS03030	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
XFC3_RS03035	COG0268	Binds directly to 16S ribosomal RNA
XFC3_RS03040	COG0728	peptidoglycan biosynthetic process
XFC3_RS03050	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
XFC3_RS03055	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
XFC3_RS03095	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XFC3_RS03095	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
XFC3_RS03165	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
XFC3_RS03200	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XFC3_RS03205	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XFC3_RS03210	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
XFC3_RS03210	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
XFC3_RS03230	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
XFC3_RS03235	COG0066	3-isopropylmalate dehydratase activity
XFC3_RS03240	COG0473	3-isopropylmalate dehydrogenase activity
XFC3_RS03270	COG0438	transferase activity, transferring glycosyl groups
XFC3_RS03285	COG0438	transferase activity, transferring glycosyl groups
XFC3_RS03290	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
XFC3_RS03295	COG0745	RESPONSE REGULATOR receiver
XFC3_RS03300	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
XFC3_RS03305	COG2954	triphosphatase activity
XFC3_RS03310	COG1472	Belongs to the glycosyl hydrolase 3 family
XFC3_RS03315	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
XFC3_RS03325	COG1278	Cold shock
XFC3_RS03345	COG2914	Belongs to the UPF0125 (RnfH) family
XFC3_RS03350	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XFC3_RS03360	COG0497	DNA recombination
XFC3_RS03370	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
XFC3_RS03375	COG0443	Heat shock 70 kDa protein
XFC3_RS03380	COG0484	heat shock protein binding
XFC3_RS03385	COG0287	Prephenate dehydrogenase
XFC3_RS03385	COG1605	Chorismate mutase
XFC3_RS03405	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
XFC3_RS03410	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
XFC3_RS03415	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
XFC3_RS03430	COG4555	ABC transporter
XFC3_RS03435	COG1668	transmembrane transport
XFC3_RS03445	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
XFC3_RS03450	COG1605	Chorismate mutase
XFC3_RS03450	COG0077	Prephenate dehydratase
XFC3_RS03455	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
XFC3_RS03495	COG3772	lysozyme
XFC3_RS03510	COG0322	excinuclease ABC activity
XFC3_RS03515	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
XFC3_RS03560	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
XFC3_RS03565	COG0489	protein tyrosine kinase activity
XFC3_RS03570	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
XFC3_RS03575	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
XFC3_RS03635	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
XFC3_RS03645	COG1192	Involved in chromosome partitioning
XFC3_RS03650	COG1475	DNA binding
XFC3_RS03660	COG0463	Glycosyl transferase, family 2
XFC3_RS03670	COG0318	PFAM AMP-dependent synthetase and ligase
XFC3_RS03680	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
XFC3_RS03685	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
XFC3_RS03695	COG0676	glucose-6-phosphate 1-epimerase activity
XFC3_RS03705	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
XFC3_RS03725	COG1297	OPT oligopeptide transporter protein
XFC3_RS03730	COG1506	peptidase
XFC3_RS03730	COG0823	Involved in the tonB-independent uptake of proteins
XFC3_RS03735	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XFC3_RS03745	COG1971	Probably functions as a manganese efflux pump
XFC3_RS03750	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
XFC3_RS03760	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
XFC3_RS03765	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
XFC3_RS03770	COG1381	Involved in DNA repair and RecF pathway recombination
XFC3_RS03775	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
XFC3_RS03780	COG0571	ribonuclease III activity
XFC3_RS03800	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
XFC3_RS03830	COG4953	penicillin-binding protein 1C
XFC3_RS03845	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
XFC3_RS03855	COG1686	Belongs to the peptidase S11 family
XFC3_RS03865	COG1678	Uncharacterized ACR, COG1678
XFC3_RS03875	COG0540	Belongs to the ATCase OTCase family
XFC3_RS03880	COG0527	aspartate kinase activity
XFC3_RS03880	COG0460	homoserine dehydrogenase
XFC3_RS03885	COG0083	homoserine kinase activity
XFC3_RS03895	COG0124	histidyl-tRNA synthetase
XFC3_RS03905	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
XFC3_RS03910	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
XFC3_RS03920	COG0131	Imidazoleglycerol-phosphate dehydratase
XFC3_RS03920	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
XFC3_RS03930	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
XFC3_RS03945	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
XFC3_RS03950	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
XFC3_RS03955	COG0235	Class ii aldolase
XFC3_RS03960	COG0531	amino acid
XFC3_RS03965	COG0531	amino acid
XFC3_RS03970	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
XFC3_RS03975	COG0277	FAD linked oxidase domain protein
XFC3_RS03980	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
XFC3_RS03990	COG2264	protein methyltransferase activity
XFC3_RS04015	COG3210	domain, Protein
XFC3_RS04105	COG2951	lytic endotransglycosylase activity
XFC3_RS04135	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
XFC3_RS04150	COG0495	leucyl-tRNA aminoacylation
XFC3_RS04160	COG3118	belongs to the thioredoxin family
XFC3_RS04170	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
XFC3_RS04185	COG2183	response to ionizing radiation
XFC3_RS04200	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
XFC3_RS04210	COG0328	RNA-DNA hybrid ribonuclease activity
XFC3_RS04215	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
XFC3_RS04310	COG3772	lysozyme
XFC3_RS04395	COG0631	protein serine/threonine phosphatase activity
XFC3_RS04410	COG0859	PFAM glycosyl transferase family 9
XFC3_RS04415	COG3642	lipopolysaccharide core region biosynthetic process
XFC3_RS04430	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
XFC3_RS04435	COG2967	ApaG domain
XFC3_RS04440	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
XFC3_RS04445	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
XFC3_RS04450	COG0704	Plays a role in the regulation of phosphate uptake
XFC3_RS04455	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
XFC3_RS04460	COG0581	inorganic phosphate transmembrane transporter activity
XFC3_RS04465	COG0573	inorganic phosphate transmembrane transporter activity
XFC3_RS04470	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
XFC3_RS04475	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
XFC3_RS04475	COG4651	solute:proton antiporter activity
XFC3_RS04490	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
XFC3_RS04500	COG0488	(ABC) transporter
XFC3_RS04655	COG0445	tRNA wobble uridine modification
XFC3_RS04695	COG1469	GTP cyclohydrolase I activity
XFC3_RS04705	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XFC3_RS04710	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XFC3_RS04720	COG2902	Dehydrogenase
XFC3_RS04725	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
XFC3_RS04760	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XFC3_RS04765	COG1028	Short-chain dehydrogenase reductase Sdr
XFC3_RS04770	COG3077	Addiction module antitoxin, RelB DinJ family
XFC3_RS04775	COG3041	Addiction module toxin RelE StbE family
XFC3_RS04805	COG4691	Plasmid stability protein
XFC3_RS04810	COG3609	addiction module antidote protein, CC2985 family
XFC3_RS05010	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
XFC3_RS05035	COG2925	Exonuclease
XFC3_RS05050	COG0025	NhaP-type Na H and K H
XFC3_RS05060	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
XFC3_RS05070	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
XFC3_RS05090	COG3079	Belongs to the UPF0149 family
XFC3_RS05095	COG0006	proline dipeptidase activity
XFC3_RS05140	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
XFC3_RS05145	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
XFC3_RS05180	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
XFC3_RS05185	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
XFC3_RS05195	COG0557	exoribonuclease II activity
XFC3_RS05205	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
XFC3_RS05210	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
XFC3_RS05215	COG0302	gtp cyclohydrolase
XFC3_RS05230	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
XFC3_RS05235	COG1289	transmembrane transporter activity
XFC3_RS05245	COG0151	Belongs to the GarS family
XFC3_RS05250	COG0138	bifunctional purine biosynthesis protein purh
XFC3_RS05265	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
XFC3_RS05275	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
XFC3_RS05295	COG0596	Alpha beta hydrolase
XFC3_RS05300	COG0727	PFAM Uncharacterised protein family (UPF0153)
XFC3_RS05315	COG0752	glycyl-tRNA synthetase alpha subunit
XFC3_RS05320	COG0751	glycine-tRNA ligase activity
XFC3_RS05335	COG0189	ligase activity
XFC3_RS05350	COG0840	transmembrane signaling receptor activity
XFC3_RS05355	COG2198	Histidine kinase
XFC3_RS05355	COG0784	Response regulator, receiver
XFC3_RS05355	COG0643	Histidine kinase
XFC3_RS05385	COG0285	dihydrofolate synthase activity
XFC3_RS05395	COG0339	signal peptide processing
XFC3_RS05420	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
XFC3_RS05425	COG1301	dicarboxylic acid transport
XFC3_RS05430	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
XFC3_RS05435	COG0357	Ribosomal RNA small subunit methyltransferase G
XFC3_RS05440	COG2091	lysine biosynthetic process via aminoadipic acid
XFC3_RS05505	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
XFC3_RS05510	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
XFC3_RS05520	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
XFC3_RS05525	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
XFC3_RS05550	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
XFC3_RS05550	COG0512	Glutamine amidotransferase of anthranilate synthase
XFC3_RS05560	COG0084	hydrolase, TatD family'
XFC3_RS05575	COG0552	protein localization to endoplasmic reticulum
XFC3_RS05585	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
XFC3_RS05595	COG0217	transcriptional regulatory protein
XFC3_RS05600	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
XFC3_RS05605	COG0632	four-way junction helicase activity
XFC3_RS05610	COG3158	transport of potassium into the cell
XFC3_RS05615	COG2255	four-way junction helicase activity
XFC3_RS05620	COG0824	Thioesterase
XFC3_RS05640	COG0823	Involved in the tonB-independent uptake of proteins
XFC3_RS05645	COG2885	chlorophyll binding
XFC3_RS05655	COG0602	queuosine metabolic process
XFC3_RS05660	COG0588	phosphoglycerate mutase activity
XFC3_RS05665	COG1515	deoxyribonuclease V activity
XFC3_RS05675	COG0386	Belongs to the glutathione peroxidase family
XFC3_RS05685	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
XFC3_RS05695	COG0406	alpha-ribazole phosphatase activity
XFC3_RS05905	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
XFC3_RS05910	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
XFC3_RS05950	COG0675	Transposase, IS605 OrfB family
XFC3_RS06080	COG2369	cell adhesion
XFC3_RS06095	COG3567	Phage-associated protein, HI1409 family
XFC3_RS06100	COG5410	chromosome segregation
XFC3_RS06125	COG3772	lysozyme
XFC3_RS06145	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
XFC3_RS06255	COG5532	Uncharacterized conserved protein (DUF2303)
XFC3_RS06295	COG0629	single-stranded DNA binding
XFC3_RS06310	COG3852	Histidine kinase
XFC3_RS06315	COG2204	response regulator
XFC3_RS06325	COG0004	ammonium transporteR
XFC3_RS06330	COG0347	Belongs to the P(II) protein family
XFC3_RS06335	COG0174	glutamine synthetase
XFC3_RS06340	COG1968	undecaprenyl-diphosphatase activity
XFC3_RS06345	COG2353	YceI-like domain
XFC3_RS06365	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
XFC3_RS06375	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
XFC3_RS06400	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
XFC3_RS06405	COG1764	response to oxidative stress
XFC3_RS06410	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
XFC3_RS06420	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
XFC3_RS06440	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
XFC3_RS06445	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
XFC3_RS06450	COG0333	Belongs to the bacterial ribosomal protein bL32 family
XFC3_RS06455	COG1399	metal-binding, possibly nucleic acid-binding protein
XFC3_RS06465	COG0714	Associated with various cellular activities
XFC3_RS06485	COG0537	adenosine 5'-monophosphoramidase activity
XFC3_RS06490	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
XFC3_RS06495	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
XFC3_RS06515	COG0338	D12 class N6 adenine-specific DNA methyltransferase
XFC3_RS06525	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
XFC3_RS06530	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
XFC3_RS06535	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
XFC3_RS06560	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
XFC3_RS06560	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
XFC3_RS06565	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
XFC3_RS06650	COG0629	single-stranded DNA binding
XFC3_RS06660	COG0270	DNA (cytosine-5-)-methyltransferase activity
XFC3_RS06835	COG1064	alcohol dehydrogenase
XFC3_RS06845	COG4221	oxidoreductase activity
XFC3_RS06855	COG3386	PFAM SMP-30 Gluconolaconase
XFC3_RS06860	COG1028	Short-chain dehydrogenase reductase Sdr
XFC3_RS06865	COG2133	pyrroloquinoline quinone binding
XFC3_RS06895	COG1064	alcohol dehydrogenase
XFC3_RS06905	COG1902	pentaerythritol trinitrate reductase activity
XFC3_RS06910	COG0583	DNA-binding transcription factor activity
XFC3_RS06915	COG0667	Aldo Keto reductase
XFC3_RS06935	COG1942	4-Oxalocrotonate Tautomerase
XFC3_RS06940	COG0667	Aldo Keto reductase
XFC3_RS06945	COG0667	Aldo Keto reductase
XFC3_RS06950	COG0583	DNA-binding transcription factor activity
XFC3_RS06960	COG1396	sequence-specific DNA binding
XFC3_RS06970	COG0582	viral genome integration into host DNA
XFC3_RS06980	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
XFC3_RS06985	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
XFC3_RS06990	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
XFC3_RS06995	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
XFC3_RS07010	COG0251	oxidation-reduction process
XFC3_RS07015	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
XFC3_RS07015	COG0392	lysyltransferase activity
XFC3_RS07030	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
XFC3_RS07040	COG0463	Glycosyl transferase, family 2
XFC3_RS07090	COG0181	hydroxymethylbilane synthase activity
XFC3_RS07100	COG3275	phosphorelay sensor kinase activity
XFC3_RS07110	COG2943	transferase activity, transferring hexosyl groups
XFC3_RS07125	COG2226	methyltransferase
XFC3_RS07140	COG2027	D-alanyl-D-alanine carboxypeptidase
XFC3_RS07150	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
XFC3_RS07165	COG2900	Belongs to the SlyX family
XFC3_RS07180	COG0386	Belongs to the glutathione peroxidase family
XFC3_RS07190	COG1131	(ABC) transporter
XFC3_RS07210	COG3657	addiction module killer protein
XFC3_RS07215	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
XFC3_RS07310	COG2369	cell adhesion
XFC3_RS07315	COG3567	Phage-associated protein, HI1409 family
XFC3_RS07320	COG5410	chromosome segregation
XFC3_RS07345	COG3772	lysozyme
XFC3_RS07365	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
XFC3_RS07400	COG0114	fumarate hydratase activity
XFC3_RS07445	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
XFC3_RS07465	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
XFC3_RS07470	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
XFC3_RS07475	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
XFC3_RS07495	COG0583	DNA-binding transcription factor activity
XFC3_RS07500	COG3634	alkyl hydroperoxide reductase activity
XFC3_RS07520	COG1450	Type ii and iii secretion system protein
XFC3_RS07535	COG3166	PFAM Fimbrial assembly family protein
XFC3_RS07540	COG3156	type II secretion system protein K
XFC3_RS07545	COG4795	General secretion pathway protein
XFC3_RS07550	COG2165	general secretion pathway protein
XFC3_RS07555	COG4970	Tfp pilus assembly protein FimT
XFC3_RS07560	COG2165	general secretion pathway protein
XFC3_RS07565	COG1459	type II secretion system
XFC3_RS07570	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
XFC3_RS07575	COG5295	Hep Hag repeat protein
XFC3_RS07595	COG2890	protein-(glutamine-N5) methyltransferase activity
XFC3_RS07605	COG0596	Alpha beta hydrolase
XFC3_RS07620	COG0635	Involved in the biosynthesis of porphyrin-containing compound
XFC3_RS07625	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
XFC3_RS07635	COG1561	YicC-like family, N-terminal region
XFC3_RS07640	COG0194	GDP metabolic process
XFC3_RS07645	COG1758	RNA polymerase activity
XFC3_RS07650	COG2895	sulfate adenylyltransferase (ATP) activity
XFC3_RS07650	COG0529	Catalyzes the synthesis of activated sulfate
XFC3_RS07655	COG0175	sulfate reduction
XFC3_RS07660	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
XFC3_RS07665	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
XFC3_RS07670	COG0175	sulfate reduction
XFC3_RS07685	COG2912	Transglutaminase-like superfamily
XFC3_RS07710	COG0308	aminopeptidase N
XFC3_RS07715	COG2226	methyltransferase
XFC3_RS07750	COG3617	BRO family, N-terminal domain
XFC3_RS07860	COG3772	lysozyme
XFC3_RS08005	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
XFC3_RS08015	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
XFC3_RS08025	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
XFC3_RS08045	COG1959	2 iron, 2 sulfur cluster binding
XFC3_RS08050	COG0719	Fe-S assembly protein
XFC3_RS08055	COG0396	ATPase activity
XFC3_RS08060	COG0719	Fe-S assembly protein
XFC3_RS08065	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
XFC3_RS08080	COG0297	glycogen (starch) synthase activity
XFC3_RS08085	COG0726	polysaccharide deacetylase
XFC3_RS08090	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
XFC3_RS08095	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
XFC3_RS08100	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
XFC3_RS08105	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
XFC3_RS08110	COG1609	Transcriptional regulator
XFC3_RS08125	COG0837	glucose binding
XFC3_RS08140	COG1028	Short-chain dehydrogenase reductase Sdr
XFC3_RS08145	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
XFC3_RS08150	COG4191	Histidine kinase
XFC3_RS08155	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
XFC3_RS08160	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
XFC3_RS08165	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
XFC3_RS08175	COG1674	ftsk spoiiie
XFC3_RS08180	COG0492	ferredoxin-NADP+ reductase activity
XFC3_RS08190	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
XFC3_RS08195	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
XFC3_RS08205	COG0542	response to heat
XFC3_RS08210	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
XFC3_RS08220	COG0482	sulfurtransferase activity
XFC3_RS08225	COG2915	High frequency lysogenization protein hflD homolog
XFC3_RS08235	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
XFC3_RS08260	COG0218	Necessary for normal cell division and for the maintenance of normal septation
XFC3_RS08265	COG3572	ergothioneine biosynthetic process
XFC3_RS08275	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
XFC3_RS08280	COG4974	Belongs to the 'phage' integrase family
XFC3_RS08285	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
XFC3_RS08325	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
XFC3_RS08330	COG0271	Belongs to the BolA IbaG family
XFC3_RS08340	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
XFC3_RS08355	COG1137	ATPase activity
XFC3_RS08375	COG1660	Displays ATPase and GTPase activities
XFC3_RS08385	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
XFC3_RS08390	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
XFC3_RS08410	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
XFC3_RS08415	COG0629	single-stranded DNA binding
XFC3_RS08420	COG0142	geranyltranstransferase activity
XFC3_RS08425	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
XFC3_RS08430	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
XFC3_RS08435	COG1845	cytochrome c oxidase, subunit III
XFC3_RS08440	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
XFC3_RS08445	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
XFC3_RS08445	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
XFC3_RS08460	COG1643	Atp-dependent helicase
XFC3_RS08465	COG0783	Belongs to the Dps family
XFC3_RS08470	COG0514	ATP-dependent DNA helicase (RecQ)
XFC3_RS08480	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
XFC3_RS08490	COG0159	tryptophan synthase activity
XFC3_RS08495	COG0133	tryptophan synthase activity
XFC3_RS08500	COG0135	phosphoribosylanthranilate isomerase activity
XFC3_RS08505	COG0101	tRNA pseudouridine synthase activity
XFC3_RS08515	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
XFC3_RS08525	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
XFC3_RS08530	COG2890	protein-(glutamine-N5) methyltransferase activity
XFC3_RS08540	COG0688	phosphatidylethanolamine metabolic process
XFC3_RS08550	COG0741	lytic transglycosylase activity
XFC3_RS08555	COG0617	tRNA 3'-terminal CCA addition
XFC3_RS08560	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
XFC3_RS08565	COG0109	protoheme IX farnesyltransferase activity
XFC3_RS08575	COG0156	8-amino-7-oxononanoate synthase activity
XFC3_RS08580	COG2267	carboxylic ester hydrolase activity
XFC3_RS08590	COG1846	Transcriptional regulator
XFC3_RS08600	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
XFC3_RS08610	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
XFC3_RS08615	COG4208	sulfate ABC transporter
XFC3_RS08620	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
XFC3_RS08635	COG3142	Participates in the control of copper homeostasis
XFC3_RS08645	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
XFC3_RS08650	COG0259	pyridoxamine-phosphate oxidase activity
XFC3_RS08660	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
XFC3_RS08665	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
XFC3_RS08675	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
XFC3_RS08685	COG0784	Response regulator, receiver
XFC3_RS08685	COG2205	protein histidine kinase activity
XFC3_RS08685	COG2198	Histidine kinase
XFC3_RS08690	COG2353	YceI-like domain
XFC3_RS08695	COG3038	cytochrome b561
XFC3_RS08705	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
XFC3_RS08725	COG0850	regulation of cytokinetic process
XFC3_RS08730	COG2894	cell division
XFC3_RS08750	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
XFC3_RS08755	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
XFC3_RS08760	COG0772	Belongs to the SEDS family
XFC3_RS08765	COG0768	penicillin binding
XFC3_RS08770	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
XFC3_RS08775	COG1792	Involved in formation and maintenance of cell shape
XFC3_RS08780	COG1077	Cell shape determining protein MreB Mrl
XFC3_RS08835	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
XFC3_RS08840	COG1127	ABC transporter
XFC3_RS08845	COG3218	ABC-type transport auxiliary lipoprotein component
XFC3_RS08845	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
XFC3_RS08860	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
XFC3_RS08860	COG0644	oxidoreductase
XFC3_RS08870	COG2840	Smr protein MutS2
XFC3_RS08875	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
XFC3_RS08880	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
XFC3_RS08885	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
XFC3_RS08890	COG0148	phosphopyruvate hydratase activity
XFC3_RS08895	COG2877	3-deoxy-8-phosphooctulonate synthase activity
XFC3_RS08900	COG0504	CTP synthase activity
XFC3_RS08930	COG1253	flavin adenine dinucleotide binding
XFC3_RS08935	COG2733	membrane
XFC3_RS08955	COG2921	Belongs to the UPF0250 family
XFC3_RS08960	COG0321	lipoyl(octanoyl) transferase activity
XFC3_RS08965	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
XFC3_RS08970	COG5297	Belongs to the glycosyl hydrolase family 6
XFC3_RS08990	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
XFC3_RS09000	COG0668	transmembrane transport
XFC3_RS09005	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
XFC3_RS09025	COG2373	Large extracellular alpha-helical protein
XFC3_RS09120	COG2911	Protein conserved in bacteria
XFC3_RS09125	COG0729	surface antigen
XFC3_RS09130	COG1956	GAF domain-containing protein
XFC3_RS09135	COG1643	Atp-dependent helicase
XFC3_RS09160	COG1131	(ABC) transporter
XFC3_RS09165	COG0842	Transport permease protein
XFC3_RS09205	COG1217	gtp-binding protein TYPA
XFC3_RS09210	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
XFC3_RS09215	COG0039	L-malate dehydrogenase activity
XFC3_RS09220	COG0625	glutathione transferase activity
XFC3_RS09225	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XFC3_RS09275	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
XFC3_RS09280	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
XFC3_RS09315	COG0776	regulation of translation
XFC3_RS09325	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
XFC3_RS09330	COG0740	serine-type endopeptidase activity
XFC3_RS09335	COG0544	peptidyl-prolyl cis-trans isomerase activity
XFC3_RS09350	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
XFC3_RS09360	COG5380	lipid catabolic process
XFC3_RS09370	COG0606	chelatase, subunit chli
XFC3_RS09375	COG2960	long-chain fatty acid transporting porin activity
XFC3_RS09380	COG0203	ribosomal protein L17
XFC3_RS09390	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
XFC3_RS09395	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
XFC3_RS09400	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
XFC3_RS09405	COG0201	protein transport
XFC3_RS09410	COG0200	Binds to the 23S rRNA
XFC3_RS09415	COG1841	ribosomal large subunit assembly
XFC3_RS09420	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
XFC3_RS09430	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
XFC3_RS09435	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
XFC3_RS09440	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
XFC3_RS09445	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
XFC3_RS09450	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
XFC3_RS09460	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
XFC3_RS09465	COG0255	Belongs to the universal ribosomal protein uL29 family
XFC3_RS09475	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
XFC3_RS09480	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
XFC3_RS09485	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
XFC3_RS09490	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
XFC3_RS09495	COG0089	rRNA binding
XFC3_RS09500	COG0088	Forms part of the polypeptide exit tunnel
XFC3_RS09505	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
XFC3_RS09520	COG0356	it plays a direct role in the translocation of protons across the membrane
XFC3_RS09530	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
XFC3_RS09535	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
XFC3_RS09540	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
XFC3_RS09545	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
XFC3_RS09550	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
XFC3_RS09555	COG0355	proton-transporting ATP synthase activity, rotational mechanism
XFC3_RS09565	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
XFC3_RS09580	COG1064	alcohol dehydrogenase
XFC3_RS09595	COG0583	DNA-binding transcription factor activity
XFC3_RS09600	COG0312	modulator of DNA gyrase
XFC3_RS09605	COG3028	Belongs to the UPF0307 family
XFC3_RS09610	COG0312	modulator of DNA gyrase
XFC3_RS09625	COG0424	maF-like protein
XFC3_RS09640	COG0494	nUDIX hydrolase
XFC3_RS09650	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
XFC3_RS09660	COG0019	diaminopimelate decarboxylase activity
XFC3_RS09665	COG1024	Enoyl-CoA hydratase
XFC3_RS09680	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
XFC3_RS09685	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
XFC3_RS09690	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
XFC3_RS09700	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
XFC3_RS09705	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
XFC3_RS09710	COG0505	Belongs to the CarA family
XFC3_RS09715	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
XFC3_RS09745	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
XFC3_RS09775	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XFC3_RS09795	COG1663	tetraacyldisaccharide 4'-kinase activity
XFC3_RS09800	COG1132	(ABC) transporter
XFC3_RS09810	COG0811	peptide transport
XFC3_RS09820	COG1136	(ABC) transporter
XFC3_RS09825	COG4591	ABC-type transport system involved in lipoprotein release permease component
XFC3_RS09835	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
XFC3_RS09840	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
XFC3_RS09850	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
XFC3_RS09855	COG2009	succinate dehydrogenase
XFC3_RS09865	COG0354	folic acid binding
XFC3_RS09870	COG3842	ATPase activity
XFC3_RS09875	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
XFC3_RS09880	COG0837	glucose binding
XFC3_RS09885	COG0363	glucosamine-6-phosphate deaminase activity
XFC3_RS09920	COG0528	UMP kinase activity
XFC3_RS09945	COG2067	long-chain fatty acid transport protein
XFC3_RS09950	COG0233	cytoplasmic translational termination
XFC3_RS09955	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
XFC3_RS09960	COG0575	Belongs to the CDS family
XFC3_RS09965	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
XFC3_RS09970	COG0750	zinc metalloprotease
XFC3_RS09980	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XFC3_RS09985	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
XFC3_RS09990	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XFC3_RS09995	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XFC3_RS10000	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
XFC3_RS10010	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
XFC3_RS10060	COG1946	Acyl-CoA thioesterase
XFC3_RS10070	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
XFC3_RS10080	COG1914	H( )-stimulated, divalent metal cation uptake system
XFC3_RS10125	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
XFC3_RS10130	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
XFC3_RS10135	COG0165	Argininosuccinate lyase
XFC3_RS10140	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
XFC3_RS10145	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
XFC3_RS10150	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
XFC3_RS10155	COG0137	argininosuccinate synthase activity
XFC3_RS10160	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
XFC3_RS10175	COG0215	cysteine-tRNA ligase activity
XFC3_RS10180	COG2166	iron-sulfur cluster assembly
XFC3_RS10200	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
XFC3_RS10205	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
XFC3_RS10225	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
XFC3_RS10235	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
XFC3_RS10240	COG0742	ribosomal rna small subunit methyltransferase
XFC3_RS10245	COG0326	Molecular chaperone. Has ATPase activity
XFC3_RS10250	COG0280	phosphate acetyltransferase
XFC3_RS10250	COG0281	malic enzyme
XFC3_RS10255	COG1301	dicarboxylic acid transport
XFC3_RS10385	COG3772	lysozyme
XFC3_RS10470	COG3617	BRO family, N-terminal domain
XFC3_RS10640	COG3772	lysozyme
XFC3_RS10750	COG3617	BRO family, N-terminal domain
XFC3_RS10795	COG0556	nucleotide-excision repair
XFC3_RS10810	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
XFC3_RS10820	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
XFC3_RS10840	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
XFC3_RS10845	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
XFC3_RS10850	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
XFC3_RS10865	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
XFC3_RS10865	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
XFC3_RS10870	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
XFC3_RS10880	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
XFC3_RS10885	COG0488	(ABC) transporter
XFC3_RS10890	COG0579	oxidoreductase
XFC3_RS10895	COG3011	Protein conserved in bacteria
XFC3_RS10905	COG1496	oxidoreductase activity
XFC3_RS10910	COG0564	pseudouridine synthase activity
XFC3_RS10915	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XFC3_RS10935	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
XFC3_RS10935	COG1918	ferrous iron import across plasma membrane
XFC3_RS10945	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
XFC3_RS10955	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
XFC3_RS10970	COG0758	DNA mediated transformation
XFC3_RS10975	COG2922	Belongs to the Smg family
XFC3_RS10980	COG1754	DNA topoisomerase type I activity
XFC3_RS10980	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
XFC3_RS10985	COG0009	L-threonylcarbamoyladenylate synthase
XFC3_RS11020	COG2969	positive regulation of protein catabolic process
XFC3_RS11025	COG0625	glutathione transferase activity
XFC3_RS11030	COG2857	Cytochrome c1
XFC3_RS11035	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
XFC3_RS11040	COG0723	plastoquinol--plastocyanin reductase activity
XFC3_RS11045	COG0741	lytic transglycosylase activity
XFC3_RS11050	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
XFC3_RS11055	COG1702	phosphate starvation-inducible protein PhoH
XFC3_RS11060	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
XFC3_RS11070	COG4535	Mg2 and Co2 transporter CorC
XFC3_RS11135	COG3210	domain, Protein
XFC3_RS11160	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
XFC3_RS11170	COG1199	ATP-dependent helicase activity
XFC3_RS11180	COG0288	reversible hydration of carbon dioxide
XFC3_RS11205	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
XFC3_RS11210	COG2011	ABC-type metal ion transport system permease component
XFC3_RS11215	COG1464	Belongs to the NlpA lipoprotein family
XFC3_RS11230	COG0508	dehydrogenase complex catalyzes the overall conversion of
XFC3_RS11235	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
XFC3_RS11250	COG0626	cystathionine gamma-synthase activity
XFC3_RS11255	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
XFC3_RS11260	COG0739	heme binding
XFC3_RS11275	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
XFC3_RS11280	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
XFC3_RS11285	COG1238	metal cluster binding
XFC3_RS11310	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
XFC3_RS11315	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XFC3_RS11320	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
XFC3_RS11325	COG1388	LysM domain
XFC3_RS11325	COG3858	chitin binding
XFC3_RS11330	COG3525	Glycosyl hydrolase, family 20, catalytic domain
XFC3_RS11340	COG1472	Belongs to the glycosyl hydrolase 3 family
XFC3_RS11355	COG3537	Alpha-1,2-mannosidase
XFC3_RS11365	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
XFC3_RS11370	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
XFC3_RS11375	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
XFC3_RS11385	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XFC3_RS11390	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XFC3_RS11395	COG0583	DNA-binding transcription factor activity
XFC3_RS11425	COG3588	fructose-bisphosphate aldolase
XFC3_RS11435	COG0469	pyruvate kinase activity
XFC3_RS11445	COG0126	phosphoglycerate kinase activity
XFC3_RS11450	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
XFC3_RS11455	COG0735	belongs to the Fur family
XFC3_RS11465	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XFC3_RS11465	COG5297	Belongs to the glycosyl hydrolase family 6
XFC3_RS11475	COG0612	Peptidase, M16
XFC3_RS11490	COG4305	rare lipoprotein A
XFC3_RS11495	COG0653	protein targeting
XFC3_RS11500	COG0739	heme binding
XFC3_RS11510	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
XFC3_RS11520	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
XFC3_RS11530	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
XFC3_RS11535	COG1181	Belongs to the D-alanine--D-alanine ligase family
XFC3_RS11540	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
XFC3_RS11545	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
XFC3_RS11555	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
XFC3_RS11560	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
XFC3_RS11565	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
XFC3_RS11575	COG3116	cell division
XFC3_RS11580	COG0275	rRNA processing
XFC3_RS11585	COG2001	Belongs to the MraZ family
XFC3_RS11600	COG0471	metal ion transport
XFC3_RS11600	COG3273	potassium ion transport
XFC3_RS11605	COG0220	tRNA (guanine-N7-)-methyltransferase activity
XFC3_RS11610	COG2022	thiamine diphosphate biosynthetic process
XFC3_RS11640	COG2755	lipolytic protein G-D-S-L family
XFC3_RS11640	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
XFC3_RS11665	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
XFC3_RS11690	COG3453	Protein conserved in bacteria
XFC3_RS11690	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
XFC3_RS11695	COG0640	Transcriptional regulator
XFC3_RS11700	COG2391	methyltransferase activity
XFC3_RS11705	COG2391	methyltransferase activity
XFC3_RS11710	COG0730	response to heat
XFC3_RS11715	COG0717	Belongs to the dCTP deaminase family
XFC3_RS11725	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
XFC3_RS11730	COG0860	N-Acetylmuramoyl-L-alanine amidase
XFC3_RS11735	COG0802	atpase or kinase
XFC3_RS11740	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
XFC3_RS11740	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
XFC3_RS11750	COG1570	exodeoxyribonuclease VII activity
XFC3_RS11775	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
XFC3_RS11795	COG0776	regulation of translation
XFC3_RS11800	COG0072	phenylalanine-tRNA ligase activity
XFC3_RS11800	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
XFC3_RS11805	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
XFC3_RS11810	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
XFC3_RS11820	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
XFC3_RS11825	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
XFC3_RS11895	COG2944	sequence-specific DNA binding
XFC3_RS11965	COG3772	lysozyme
XFC3_RS12075	COG3617	BRO family, N-terminal domain
XFC3_RS12105	COG0582	viral genome integration into host DNA
XFC3_RS12125	COG0745	RESPONSE REGULATOR receiver
XFC3_RS12130	COG0642	Histidine kinase
XFC3_RS12135	COG0237	dephospho-CoA kinase activity
XFC3_RS12140	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
XFC3_RS12190	COG0045	succinate-CoA ligase (ADP-forming) activity
XFC3_RS12195	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
XFC3_RS12205	COG2831	hemolysin activation secretion protein
XFC3_RS12220	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
XFC3_RS12230	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
XFC3_RS12240	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
XFC3_RS12245	COG3115	cell septum assembly
XFC3_RS12255	COG0359	binds to the 23S rRNA
XFC3_RS12260	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
XFC3_RS12270	COG0316	Belongs to the HesB IscA family
XFC3_RS12275	COG0017	Asparaginyl-tRNA synthetase
XFC3_RS12300	COG0167	dihydroorotate dehydrogenase activity
XFC3_RS12305	COG0812	UDP-N-acetylmuramate dehydrogenase activity
XFC3_RS12310	COG0697	spore germination
XFC3_RS12320	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
XFC3_RS12335	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
XFC3_RS12340	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
XFC3_RS12355	COG1132	(ABC) transporter
XFC3_RS12365	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
XFC3_RS12370	COG1538	Outer membrane efflux protein
XFC3_RS12375	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XFC3_RS12390	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
XFC3_RS12405	COG4783	chaperone-mediated protein folding
XFC3_RS12415	COG0473	3-isopropylmalate dehydrogenase activity
XFC3_RS12425	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
XFC3_RS12435	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
XFC3_RS12445	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
XFC3_RS12445	COG0316	Belongs to the HesB IscA family
XFC3_RS12450	COG2154	pterin-4-alpha-carbinolamine dehydratase
XFC3_RS12460	COG0564	pseudouridine synthase activity
XFC3_RS12465	COG1530	ribonuclease E activity
XFC3_RS12470	COG2197	response regulator
XFC3_RS12475	COG1054	Belongs to the UPF0176 family
XFC3_RS12490	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
XFC3_RS12505	COG0488	(ABC) transporter
XFC3_RS12515	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
XFC3_RS12520	COG1278	Cold shock
XFC3_RS12530	COG0501	Belongs to the peptidase M48B family
XFC3_RS12540	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
XFC3_RS12545	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
XFC3_RS12550	COG0049	tRNA binding
XFC3_RS12560	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
XFC3_RS12565	COG0085	RNA polymerase activity
XFC3_RS12570	COG0222	ribosome binding
XFC3_RS12575	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
XFC3_RS12580	COG0081	regulation of translation
XFC3_RS12585	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
XFC3_RS12590	COG0250	Participates in transcription elongation, termination and antitermination
XFC3_RS12595	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
XFC3_RS12605	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
XFC3_RS12625	COG0012	GTP binding
XFC3_RS12630	COG0193	aminoacyl-tRNA hydrolase activity
XFC3_RS12635	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
XFC3_RS12640	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
XFC3_RS12650	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
XFC3_RS12655	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
XFC3_RS12665	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
XFC3_RS12670	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
XFC3_RS12680	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
XFC3_RS12680	COG0116	Belongs to the methyltransferase superfamily
XFC3_RS12735	COG2095	MarC family integral membrane protein
XFC3_RS12745	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
XFC3_RS12760	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
XFC3_RS12775	COG2132	Multicopper oxidase
XFC3_RS12785	COG0210	DNA helicase
XFC3_RS12790	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
XFC3_RS12795	COG0616	signal peptide processing
XFC3_RS12815	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
XFC3_RS12825	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
XFC3_RS12830	COG2201	protein-glutamate methylesterase activity
XFC3_RS12835	COG2177	Part of the ABC transporter FtsEX involved in
XFC3_RS12840	COG2884	Cell division ATP-binding protein ftsE
XFC3_RS12845	COG0513	Belongs to the DEAD box helicase family
XFC3_RS12850	COG3118	belongs to the thioredoxin family
XFC3_RS12855	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
XFC3_RS12870	COG0793	Belongs to the peptidase S41A family
XFC3_RS12875	COG4942	peptidase
XFC3_RS12890	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XFC3_RS12895	COG0493	'glutamate synthase
XFC3_RS12900	COG0069	glutamate synthase activity
XFC3_RS12900	COG0070	glutamate synthase
XFC3_RS12900	COG0067	glutamate synthase
XFC3_RS12935	COG1028	Short-chain dehydrogenase reductase Sdr
XFC3_RS12960	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
XFC3_RS12985	COG0732	type I restriction modification DNA specificity domain
XFC3_RS13005	COG1280	lysine exporter protein (LysE YggA)
XFC3_RS13020	COG4942	peptidase
XFC3_RS13050	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
XFC3_RS13065	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
XFC3_RS13190	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
XFC3_RS13195	COG3657	addiction module killer protein
XFC3_RS13265	COG3210	domain, Protein
XFC3_RS13280	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
XFC3_RS13290	COG0706	membrane insertase activity
XFC3_RS13295	COG0594	ribonuclease P activity