locus-tag	class	description
XFHB_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
XFHB_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
XFHB_RS00025	COG0187	DNA topoisomerase II activity
XFHB_RS00035	COG0501	Belongs to the peptidase M48B family
XFHB_RS00075	COG0408	coproporphyrinogen oxidase activity
XFHB_RS00105	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
XFHB_RS00120	COG4969	Belongs to the N-Me-Phe pilin family
XFHB_RS00150	COG0284	orotidine-5'-phosphate decarboxylase activity
XFHB_RS00185	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
XFHB_RS00195	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
XFHB_RS00205	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
XFHB_RS00210	COG0511	ligase activity, forming carbon-carbon bonds
XFHB_RS00215	COG0439	Biotin carboxylase
XFHB_RS00220	COG0210	DNA helicase
XFHB_RS00230	COG1017	nitric oxide dioxygenase activity
XFHB_RS00230	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
XFHB_RS00245	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
XFHB_RS00255	COG1040	competence protein
XFHB_RS00260	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
XFHB_RS00265	COG1752	Esterase of the alpha-beta hydrolase superfamily
XFHB_RS00275	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
XFHB_RS00310	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
XFHB_RS00320	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
XFHB_RS00350	COG3121	Chaperone
XFHB_RS00355	COG3539	Fimbrial protein
XFHB_RS00360	COG1546	Belongs to the CinA family
XFHB_RS00365	COG0477	Major facilitator Superfamily
XFHB_RS00370	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
XFHB_RS00375	COG1923	regulation of RNA biosynthetic process
XFHB_RS00380	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
XFHB_RS00385	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
XFHB_RS00390	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
XFHB_RS00400	COG1534	Rna-binding protein
XFHB_RS00410	COG0129	dihydroxy-acid dehydratase activity
XFHB_RS00435	COG1560	Kdo2-lipid A biosynthetic process
XFHB_RS00440	COG1519	Transferase
XFHB_RS00455	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
XFHB_RS00460	COG0336	Belongs to the RNA methyltransferase TrmD family
XFHB_RS00465	COG0335	large ribosomal subunit rRNA binding
XFHB_RS00485	COG2171	N-acyltransferase activity
XFHB_RS00490	COG1393	Belongs to the ArsC family
XFHB_RS00495	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
XFHB_RS00500	COG0367	asparagine synthase
XFHB_RS00510	COG2070	2-Nitropropane dioxygenase
XFHB_RS00520	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
XFHB_RS00540	COG0339	signal peptide processing
XFHB_RS00565	COG0525	valine-tRNA ligase activity
XFHB_RS00605	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
XFHB_RS00615	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
XFHB_RS00625	COG4221	oxidoreductase activity
XFHB_RS00640	COG2003	Belongs to the UPF0758 family
XFHB_RS00645	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
XFHB_RS00655	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
XFHB_RS00665	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
XFHB_RS00705	COG2223	nitrite transmembrane transporter activity
XFHB_RS00710	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
XFHB_RS00715	COG0739	heme binding
XFHB_RS00720	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
XFHB_RS00750	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
XFHB_RS00765	COG1028	Short-chain dehydrogenase reductase Sdr
XFHB_RS00770	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
XFHB_RS00775	COG1272	protein, Hemolysin III
XFHB_RS00780	COG0463	Glycosyl transferase, family 2
XFHB_RS00785	COG0084	hydrolase, TatD family'
XFHB_RS00800	COG0509	glycine decarboxylation via glycine cleavage system
XFHB_RS00815	COG0330	HflC and HflK could
XFHB_RS00820	COG3956	TIGRFAM MazG family protein
XFHB_RS00825	COG1218	3'(2'),5'-bisphosphate nucleotidase
XFHB_RS00830	COG0494	nUDIX hydrolase
XFHB_RS00840	COG1385	rRNA (uridine-N3-)-methyltransferase activity
XFHB_RS00850	COG0513	Belongs to the DEAD box helicase family
XFHB_RS00855	COG0720	synthase
XFHB_RS00885	COG1981	membrane
XFHB_RS00895	COG0587	DNA-directed DNA polymerase activity
XFHB_RS00925	COG0512	Glutamine amidotransferase of anthranilate synthase
XFHB_RS00930	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
XFHB_RS00935	COG0134	indole-3-glycerol-phosphate synthase activity
XFHB_RS00960	COG0006	proline dipeptidase activity
XFHB_RS00975	COG0343	queuine tRNA-ribosyltransferase activity
XFHB_RS00980	COG1862	Preprotein translocase
XFHB_RS00985	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
XFHB_RS00990	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
XFHB_RS01000	COG0617	tRNA 3'-terminal CCA addition
XFHB_RS01010	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
XFHB_RS01015	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
XFHB_RS01020	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
XFHB_RS01025	COG0166	Belongs to the GPI family
XFHB_RS01040	COG0779	Required for maturation of 30S ribosomal subunits
XFHB_RS01045	COG0195	Participates in both transcription termination and antitermination
XFHB_RS01050	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
XFHB_RS01055	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
XFHB_RS01060	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
XFHB_RS01070	COG1185	polyribonucleotide nucleotidyltransferase activity
XFHB_RS01075	COG1733	regulation of RNA biosynthetic process
XFHB_RS01080	COG0702	epimerase
XFHB_RS01135	COG2086	electron transfer activity
XFHB_RS01165	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
XFHB_RS01200	COG0477	Major facilitator Superfamily
XFHB_RS01215	COG0563	adenylate kinase activity
XFHB_RS01220	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
XFHB_RS01225	COG0671	phosphoesterase, PA-phosphatase related
XFHB_RS01235	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
XFHB_RS01240	COG0628	permease
XFHB_RS01260	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
XFHB_RS01265	COG1090	epimerase
XFHB_RS01270	COG0318	PFAM AMP-dependent synthetase and ligase
XFHB_RS01295	COG1049	propionate catabolic process, 2-methylcitrate cycle
XFHB_RS01315	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
XFHB_RS01365	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XFHB_RS01375	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XFHB_RS01385	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
XFHB_RS01390	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
XFHB_RS01395	COG1034	ATP synthesis coupled electron transport
XFHB_RS01415	COG0713	ATP synthesis coupled electron transport
XFHB_RS01430	COG1007	ATP synthesis coupled electron transport
XFHB_RS01435	COG1028	Short-chain dehydrogenase reductase Sdr
XFHB_RS01440	COG2851	Citrate transporter
XFHB_RS01455	COG0642	Histidine kinase
XFHB_RS01475	COG0675	Transposase, IS605 OrfB family
XFHB_RS01520	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
XFHB_RS01525	COG4206	TonB-dependent receptor
XFHB_RS01530	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
XFHB_RS01550	COG0277	FAD linked oxidase domain protein
XFHB_RS01555	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
XFHB_RS01565	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
XFHB_RS01570	COG2124	cytochrome p450
XFHB_RS01580	COG0305	Participates in initiation and elongation during chromosome replication
XFHB_RS01595	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
XFHB_RS01600	COG0667	Aldo Keto reductase
XFHB_RS01605	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
XFHB_RS01640	COG2194	sulfuric ester hydrolase activity
XFHB_RS01650	COG0352	thiamine-phosphate diphosphorylase activity
XFHB_RS01660	COG0542	response to heat
XFHB_RS01680	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
XFHB_RS01705	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
XFHB_RS01720	COG0494	nUDIX hydrolase
XFHB_RS01730	COG2193	ferroxidase activity
XFHB_RS01780	COG0861	Integral membrane protein TerC family
XFHB_RS01785	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
XFHB_RS01790	COG0531	amino acid
XFHB_RS01800	COG1116	anion transmembrane transporter activity
XFHB_RS01805	COG1322	Protein conserved in bacteria
XFHB_RS01815	COG2853	Lipoprotein
XFHB_RS01830	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
XFHB_RS01835	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
XFHB_RS01840	COG1127	ABC transporter
XFHB_RS01850	COG1074	ATP-dependent DNA helicase activity
XFHB_RS01865	COG0180	Tryptophanyl-tRNA synthetase
XFHB_RS01870	COG0358	DNA primase activity
XFHB_RS01890	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
XFHB_RS01895	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
XFHB_RS01900	COG0668	transmembrane transport
XFHB_RS01920	COG1183	phosphatidylcholine synthase activity
XFHB_RS01930	COG0442	prolyl-tRNA aminoacylation
XFHB_RS01950	COG0604	alcohol dehydrogenase
XFHB_RS01955	COG0330	HflC and HflK could
XFHB_RS01960	COG0330	HflC and HflK could
XFHB_RS01970	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
XFHB_RS01975	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
XFHB_RS01980	COG0105	UTP biosynthetic process
XFHB_RS01985	COG0820	rRNA (adenine-C2-)-methyltransferase activity
XFHB_RS02005	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XFHB_RS02010	COG1160	GTP binding
XFHB_RS02015	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
XFHB_RS02030	COG4943	cyclic-guanylate-specific phosphodiesterase activity
XFHB_RS02035	COG1611	Belongs to the LOG family
XFHB_RS02040	COG4968	Prepilin-type N-terminal cleavage methylation domain
XFHB_RS02085	COG0629	single-stranded DNA binding
XFHB_RS02155	COG2856	Zn peptidase
XFHB_RS02175	COG4197	protein conserved in bacteria, prophage-related
XFHB_RS02230	COG0740	serine-type endopeptidase activity
XFHB_RS02245	COG3772	lysozyme
XFHB_RS02290	COG5449	Phage conserved hypothetical protein BR0599
XFHB_RS02395	COG2878	Part of a membrane complex involved in electron transport
XFHB_RS02400	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
XFHB_RS02400	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
XFHB_RS02410	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
XFHB_RS02415	COG3107	peptidoglycan biosynthetic process
XFHB_RS02425	COG1162	GTPase activity
XFHB_RS02430	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
XFHB_RS02445	COG0519	Catalyzes the synthesis of GMP from XMP
XFHB_RS02445	COG0518	GMP synthase (glutamine-hydrolyzing) activity
XFHB_RS02460	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
XFHB_RS02465	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
XFHB_RS02475	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
XFHB_RS02490	COG0037	tRNA processing
XFHB_RS02500	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
XFHB_RS02520	COG3590	peptidase
XFHB_RS02550	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
XFHB_RS02560	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
XFHB_RS02570	COG0628	permease
XFHB_RS02580	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
XFHB_RS02585	COG3178	'Phosphotransferase
XFHB_RS02590	COG1555	photosystem II stabilization
XFHB_RS02595	COG1477	protein flavinylation
XFHB_RS02615	COG3128	pkhd-type hydroxylase
XFHB_RS02620	COG4774	siderophore transport
XFHB_RS02640	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
XFHB_RS02655	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
XFHB_RS02690	COG0459	protein refolding
XFHB_RS02700	COG1324	tolerance protein
XFHB_RS02710	COG0352	thiamine-phosphate diphosphorylase activity
XFHB_RS02710	COG0351	phosphomethylpyrimidine kinase
XFHB_RS02720	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
XFHB_RS02825	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
XFHB_RS02840	COG2311	Membrane
XFHB_RS02850	COG0791	NLP P60 protein
XFHB_RS02855	COG0791	NLP P60 protein
XFHB_RS02865	COG1301	dicarboxylic acid transport
XFHB_RS02875	COG0037	tRNA processing
XFHB_RS02880	COG1722	exodeoxyribonuclease VII activity
XFHB_RS02885	COG0142	geranyltranstransferase activity
XFHB_RS02940	COG1028	Short-chain dehydrogenase reductase Sdr
XFHB_RS02955	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
XFHB_RS02960	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
XFHB_RS02985	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
XFHB_RS02990	COG0483	inositol monophosphate 1-phosphatase activity
XFHB_RS03000	COG1509	lysine 2,3-aminomutase activity
XFHB_RS03010	COG0402	S-adenosylhomocysteine deaminase activity
XFHB_RS03015	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
XFHB_RS03020	COG0546	phosphoglycolate phosphatase activity
XFHB_RS03035	COG5434	Belongs to the glycosyl hydrolase 28 family
XFHB_RS03040	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
XFHB_RS03060	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
XFHB_RS03065	COG1138	Cytochrome C-type biogenesis protein
XFHB_RS03070	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
XFHB_RS03090	COG4133	protoheme IX ABC transporter activity
XFHB_RS03095	COG0436	Aminotransferase
XFHB_RS03110	COG1187	pseudouridine synthase activity
XFHB_RS03115	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
XFHB_RS03120	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
XFHB_RS03145	COG1175	transmembrane transport
XFHB_RS03150	COG0395	ABC-type sugar transport system, permease component
XFHB_RS03185	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
XFHB_RS03195	COG0776	regulation of translation
XFHB_RS03205	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
XFHB_RS03220	COG1210	Utp--glucose-1-phosphate uridylyltransferase
XFHB_RS03225	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
XFHB_RS03235	COG0518	GMP synthase (glutamine-hydrolyzing) activity
XFHB_RS03235	COG0519	Catalyzes the synthesis of GMP from XMP
XFHB_RS03250	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
XFHB_RS03255	COG0261	This protein binds to 23S rRNA in the presence of protein L20
XFHB_RS03260	COG0211	Belongs to the bacterial ribosomal protein bL27 family
XFHB_RS03265	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
XFHB_RS03270	COG0268	Binds directly to 16S ribosomal RNA
XFHB_RS03275	COG0728	peptidoglycan biosynthetic process
XFHB_RS03280	COG0196	riboflavin kinase activity
XFHB_RS03285	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
XFHB_RS03290	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
XFHB_RS03320	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XFHB_RS03320	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
XFHB_RS03410	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
XFHB_RS03430	COG1064	alcohol dehydrogenase
XFHB_RS03445	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XFHB_RS03450	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XFHB_RS03455	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
XFHB_RS03455	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
XFHB_RS03475	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
XFHB_RS03480	COG0066	3-isopropylmalate dehydratase activity
XFHB_RS03485	COG0473	3-isopropylmalate dehydrogenase activity
XFHB_RS03515	COG0438	transferase activity, transferring glycosyl groups
XFHB_RS03530	COG0438	transferase activity, transferring glycosyl groups
XFHB_RS03535	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
XFHB_RS03540	COG0745	RESPONSE REGULATOR receiver
XFHB_RS03545	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
XFHB_RS03550	COG2954	triphosphatase activity
XFHB_RS03555	COG1472	Belongs to the glycosyl hydrolase 3 family
XFHB_RS03560	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
XFHB_RS03570	COG1278	Cold shock
XFHB_RS03590	COG2914	Belongs to the UPF0125 (RnfH) family
XFHB_RS03595	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XFHB_RS03605	COG0497	DNA recombination
XFHB_RS03625	COG0484	heat shock protein binding
XFHB_RS03630	COG0287	Prephenate dehydrogenase
XFHB_RS03630	COG1605	Chorismate mutase
XFHB_RS03650	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
XFHB_RS03655	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
XFHB_RS03660	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
XFHB_RS03675	COG4555	ABC transporter
XFHB_RS03680	COG1668	transmembrane transport
XFHB_RS03695	COG1605	Chorismate mutase
XFHB_RS03695	COG0077	Prephenate dehydratase
XFHB_RS03700	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
XFHB_RS03745	COG3772	lysozyme
XFHB_RS03760	COG0322	excinuclease ABC activity
XFHB_RS03765	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
XFHB_RS03810	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
XFHB_RS03815	COG0489	protein tyrosine kinase activity
XFHB_RS03820	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
XFHB_RS03825	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
XFHB_RS03855	COG3617	BRO family, N-terminal domain
XFHB_RS03975	COG3772	lysozyme
XFHB_RS04045	COG3093	addiction module antidote protein HigA
XFHB_RS04120	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
XFHB_RS04125	COG1845	cytochrome c oxidase, subunit III
XFHB_RS04130	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
XFHB_RS04135	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
XFHB_RS04140	COG0142	geranyltranstransferase activity
XFHB_RS04145	COG0629	single-stranded DNA binding
XFHB_RS04150	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
XFHB_RS04170	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
XFHB_RS04185	COG1660	Displays ATPase and GTPase activities
XFHB_RS04205	COG1137	ATPase activity
XFHB_RS04220	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
XFHB_RS04230	COG0271	Belongs to the BolA IbaG family
XFHB_RS04235	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
XFHB_RS04275	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
XFHB_RS04280	COG4974	Belongs to the 'phage' integrase family
XFHB_RS04285	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
XFHB_RS04300	COG0218	Necessary for normal cell division and for the maintenance of normal septation
XFHB_RS04320	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
XFHB_RS04330	COG2915	High frequency lysogenization protein hflD homolog
XFHB_RS04335	COG0482	sulfurtransferase activity
XFHB_RS04345	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
XFHB_RS04350	COG0542	response to heat
XFHB_RS04360	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
XFHB_RS04365	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
XFHB_RS04375	COG0492	ferredoxin-NADP+ reductase activity
XFHB_RS04380	COG1674	ftsk spoiiie
XFHB_RS04390	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
XFHB_RS04395	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
XFHB_RS04400	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
XFHB_RS04405	COG4191	Histidine kinase
XFHB_RS04410	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
XFHB_RS04415	COG1028	Short-chain dehydrogenase reductase Sdr
XFHB_RS04430	COG0837	glucose binding
XFHB_RS04445	COG1609	Transcriptional regulator
XFHB_RS04450	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
XFHB_RS04455	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
XFHB_RS04460	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
XFHB_RS04465	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
XFHB_RS04470	COG0726	polysaccharide deacetylase
XFHB_RS04475	COG0297	glycogen (starch) synthase activity
XFHB_RS04490	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
XFHB_RS04495	COG0719	Fe-S assembly protein
XFHB_RS04500	COG0396	ATPase activity
XFHB_RS04505	COG0719	Fe-S assembly protein
XFHB_RS04510	COG1959	2 iron, 2 sulfur cluster binding
XFHB_RS04530	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
XFHB_RS04540	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
XFHB_RS04550	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
XFHB_RS04560	COG2226	methyltransferase
XFHB_RS04565	COG0308	aminopeptidase N
XFHB_RS04585	COG2912	Transglutaminase-like superfamily
XFHB_RS04600	COG0175	sulfate reduction
XFHB_RS04605	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
XFHB_RS04615	COG0175	sulfate reduction
XFHB_RS04620	COG0529	Catalyzes the synthesis of activated sulfate
XFHB_RS04620	COG2895	sulfate adenylyltransferase (ATP) activity
XFHB_RS04625	COG1758	RNA polymerase activity
XFHB_RS04630	COG0194	GDP metabolic process
XFHB_RS04635	COG1561	YicC-like family, N-terminal region
XFHB_RS04640	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
XFHB_RS04645	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
XFHB_RS04650	COG0635	Involved in the biosynthesis of porphyrin-containing compound
XFHB_RS04665	COG0596	Alpha beta hydrolase
XFHB_RS04670	COG2890	protein-(glutamine-N5) methyltransferase activity
XFHB_RS04685	COG5295	Hep Hag repeat protein
XFHB_RS04690	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
XFHB_RS04695	COG1459	type II secretion system
XFHB_RS04700	COG2165	general secretion pathway protein
XFHB_RS04705	COG4970	Tfp pilus assembly protein FimT
XFHB_RS04710	COG2165	general secretion pathway protein
XFHB_RS04715	COG4795	General secretion pathway protein
XFHB_RS04720	COG3156	type II secretion system protein K
XFHB_RS04725	COG3166	PFAM Fimbrial assembly family protein
XFHB_RS04740	COG1450	Type ii and iii secretion system protein
XFHB_RS04760	COG3634	alkyl hydroperoxide reductase activity
XFHB_RS04765	COG0583	DNA-binding transcription factor activity
XFHB_RS04790	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
XFHB_RS04795	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
XFHB_RS04830	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
XFHB_RS04855	COG0567	Dehydrogenase, E1 component
XFHB_RS04860	COG2850	peptidyl-arginine hydroxylation
XFHB_RS04880	COG0114	fumarate hydratase activity
XFHB_RS04885	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
XFHB_RS05050	COG0445	tRNA wobble uridine modification
XFHB_RS05085	COG1469	GTP cyclohydrolase I activity
XFHB_RS05095	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XFHB_RS05100	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XFHB_RS05110	COG2902	Dehydrogenase
XFHB_RS05160	COG1028	Short-chain dehydrogenase reductase Sdr
XFHB_RS05165	COG3077	Addiction module antitoxin, RelB DinJ family
XFHB_RS05170	COG3041	Addiction module toxin RelE StbE family
XFHB_RS05245	COG4691	Plasmid stability protein
XFHB_RS05310	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
XFHB_RS05445	COG0629	single-stranded DNA binding
XFHB_RS05455	COG4962	Type ii secretion system protein e
XFHB_RS05470	COG3451	type IV secretory pathway VirB4
XFHB_RS05540	COG4691	Plasmid stability protein
XFHB_RS05575	COG3657	addiction module killer protein
XFHB_RS05595	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
XFHB_RS05635	COG2925	Exonuclease
XFHB_RS05650	COG0025	NhaP-type Na H and K H
XFHB_RS05660	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
XFHB_RS05670	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
XFHB_RS05690	COG3079	Belongs to the UPF0149 family
XFHB_RS05695	COG0006	proline dipeptidase activity
XFHB_RS05740	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
XFHB_RS05745	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
XFHB_RS05780	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
XFHB_RS05785	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
XFHB_RS05795	COG0557	exoribonuclease II activity
XFHB_RS05805	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
XFHB_RS05810	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
XFHB_RS05815	COG0302	gtp cyclohydrolase
XFHB_RS05830	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
XFHB_RS05835	COG1289	transmembrane transporter activity
XFHB_RS05845	COG0151	Belongs to the GarS family
XFHB_RS05850	COG0138	bifunctional purine biosynthesis protein purh
XFHB_RS05865	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
XFHB_RS05875	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
XFHB_RS05900	COG0727	PFAM Uncharacterised protein family (UPF0153)
XFHB_RS05910	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
XFHB_RS05910	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
XFHB_RS05950	COG0840	transmembrane signaling receptor activity
XFHB_RS05955	COG0643	Histidine kinase
XFHB_RS05955	COG2198	Histidine kinase
XFHB_RS05955	COG0784	Response regulator, receiver
XFHB_RS05985	COG0285	dihydrofolate synthase activity
XFHB_RS05995	COG0339	signal peptide processing
XFHB_RS06015	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
XFHB_RS06020	COG1301	dicarboxylic acid transport
XFHB_RS06025	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
XFHB_RS06030	COG0357	Ribosomal RNA small subunit methyltransferase G
XFHB_RS06035	COG2091	lysine biosynthetic process via aminoadipic acid
XFHB_RS06100	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
XFHB_RS06105	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
XFHB_RS06115	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
XFHB_RS06145	COG0512	Glutamine amidotransferase of anthranilate synthase
XFHB_RS06145	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
XFHB_RS06155	COG0084	hydrolase, TatD family'
XFHB_RS06170	COG0552	protein localization to endoplasmic reticulum
XFHB_RS06180	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
XFHB_RS06190	COG0217	transcriptional regulatory protein
XFHB_RS06195	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
XFHB_RS06200	COG0632	four-way junction helicase activity
XFHB_RS06205	COG3158	transport of potassium into the cell
XFHB_RS06210	COG2255	four-way junction helicase activity
XFHB_RS06215	COG0824	Thioesterase
XFHB_RS06235	COG0823	Involved in the tonB-independent uptake of proteins
XFHB_RS06240	COG2885	chlorophyll binding
XFHB_RS06250	COG0602	queuosine metabolic process
XFHB_RS06255	COG0588	phosphoglycerate mutase activity
XFHB_RS06260	COG1515	deoxyribonuclease V activity
XFHB_RS06270	COG0386	Belongs to the glutathione peroxidase family
XFHB_RS06280	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
XFHB_RS06290	COG0406	alpha-ribazole phosphatase activity
XFHB_RS06475	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
XFHB_RS06480	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
XFHB_RS06520	COG3852	Histidine kinase
XFHB_RS06525	COG2204	response regulator
XFHB_RS06535	COG0004	ammonium transporteR
XFHB_RS06540	COG0347	Belongs to the P(II) protein family
XFHB_RS06545	COG0174	glutamine synthetase
XFHB_RS06550	COG1968	undecaprenyl-diphosphatase activity
XFHB_RS06555	COG2353	YceI-like domain
XFHB_RS06575	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
XFHB_RS06585	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
XFHB_RS06610	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
XFHB_RS06615	COG1764	response to oxidative stress
XFHB_RS06620	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
XFHB_RS06630	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
XFHB_RS06650	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
XFHB_RS06660	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
XFHB_RS06665	COG0333	Belongs to the bacterial ribosomal protein bL32 family
XFHB_RS06670	COG1399	metal-binding, possibly nucleic acid-binding protein
XFHB_RS06680	COG0714	Associated with various cellular activities
XFHB_RS06700	COG0537	adenosine 5'-monophosphoramidase activity
XFHB_RS06710	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
XFHB_RS06745	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
XFHB_RS06750	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
XFHB_RS06755	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
XFHB_RS06785	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
XFHB_RS06875	COG0251	oxidation-reduction process
XFHB_RS06890	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
XFHB_RS06895	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
XFHB_RS06900	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
XFHB_RS06905	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
XFHB_RS06915	COG0582	viral genome integration into host DNA
XFHB_RS06925	COG1396	sequence-specific DNA binding
XFHB_RS06930	COG0583	DNA-binding transcription factor activity
XFHB_RS06935	COG0667	Aldo Keto reductase
XFHB_RS06940	COG0667	Aldo Keto reductase
XFHB_RS06945	COG1942	4-Oxalocrotonate Tautomerase
XFHB_RS06965	COG0667	Aldo Keto reductase
XFHB_RS06970	COG0583	DNA-binding transcription factor activity
XFHB_RS06975	COG1902	pentaerythritol trinitrate reductase activity
XFHB_RS06985	COG1064	alcohol dehydrogenase
XFHB_RS07015	COG2133	pyrroloquinoline quinone binding
XFHB_RS07020	COG1028	Short-chain dehydrogenase reductase Sdr
XFHB_RS07025	COG3386	PFAM SMP-30 Gluconolaconase
XFHB_RS07035	COG4221	oxidoreductase activity
XFHB_RS07045	COG1064	alcohol dehydrogenase
XFHB_RS07135	COG4978	Transcriptional regulator
XFHB_RS07135	COG0789	Transcriptional regulator
XFHB_RS07140	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
XFHB_RS07150	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XFHB_RS07155	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XFHB_RS07380	COG0270	DNA (cytosine-5-)-methyltransferase activity
XFHB_RS07390	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
XFHB_RS07395	COG0629	single-stranded DNA binding
XFHB_RS07480	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
XFHB_RS07635	COG0629	single-stranded DNA binding
XFHB_RS07645	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
XFHB_RS07650	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
XFHB_RS07650	COG0392	lysyltransferase activity
XFHB_RS07665	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
XFHB_RS07675	COG0463	Glycosyl transferase, family 2
XFHB_RS07720	COG0181	hydroxymethylbilane synthase activity
XFHB_RS07730	COG3275	phosphorelay sensor kinase activity
XFHB_RS07740	COG2943	transferase activity, transferring hexosyl groups
XFHB_RS07755	COG2226	methyltransferase
XFHB_RS07770	COG2027	D-alanyl-D-alanine carboxypeptidase
XFHB_RS07780	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
XFHB_RS07795	COG2900	Belongs to the SlyX family
XFHB_RS07810	COG0386	Belongs to the glutathione peroxidase family
XFHB_RS07820	COG1131	(ABC) transporter
XFHB_RS07840	COG3657	addiction module killer protein
XFHB_RS07845	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
XFHB_RS07995	COG2369	cell adhesion
XFHB_RS08000	COG3567	Phage-associated protein, HI1409 family
XFHB_RS08005	COG5410	chromosome segregation
XFHB_RS08030	COG3772	lysozyme
XFHB_RS08050	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
XFHB_RS08180	COG0629	single-stranded DNA binding
XFHB_RS08190	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
XFHB_RS08195	COG0392	lysyltransferase activity
XFHB_RS08195	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
XFHB_RS08210	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
XFHB_RS08220	COG0463	Glycosyl transferase, family 2
XFHB_RS08265	COG0181	hydroxymethylbilane synthase activity
XFHB_RS08275	COG3275	phosphorelay sensor kinase activity
XFHB_RS08285	COG2943	transferase activity, transferring hexosyl groups
XFHB_RS08300	COG2226	methyltransferase
XFHB_RS08315	COG2027	D-alanyl-D-alanine carboxypeptidase
XFHB_RS08325	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
XFHB_RS08340	COG2900	Belongs to the SlyX family
XFHB_RS08355	COG0386	Belongs to the glutathione peroxidase family
XFHB_RS08365	COG1131	(ABC) transporter
XFHB_RS08385	COG3657	addiction module killer protein
XFHB_RS08390	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
XFHB_RS08540	COG2369	cell adhesion
XFHB_RS08555	COG3567	Phage-associated protein, HI1409 family
XFHB_RS08560	COG5410	chromosome segregation
XFHB_RS08585	COG3772	lysozyme
XFHB_RS08640	COG0488	(ABC) transporter
XFHB_RS08650	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
XFHB_RS08660	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
XFHB_RS08660	COG4651	solute:proton antiporter activity
XFHB_RS08665	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
XFHB_RS08670	COG0573	inorganic phosphate transmembrane transporter activity
XFHB_RS08675	COG0581	inorganic phosphate transmembrane transporter activity
XFHB_RS08680	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
XFHB_RS08685	COG0704	Plays a role in the regulation of phosphate uptake
XFHB_RS08690	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
XFHB_RS08695	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
XFHB_RS08700	COG2967	ApaG domain
XFHB_RS08705	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
XFHB_RS08720	COG3642	lipopolysaccharide core region biosynthetic process
XFHB_RS08725	COG0859	PFAM glycosyl transferase family 9
XFHB_RS08740	COG0631	protein serine/threonine phosphatase activity
XFHB_RS08745	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
XFHB_RS08750	COG0328	RNA-DNA hybrid ribonuclease activity
XFHB_RS08760	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
XFHB_RS08775	COG2183	response to ionizing radiation
XFHB_RS08790	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
XFHB_RS08800	COG3118	belongs to the thioredoxin family
XFHB_RS08810	COG0495	leucyl-tRNA aminoacylation
XFHB_RS08825	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
XFHB_RS08855	COG2951	lytic endotransglycosylase activity
XFHB_RS08860	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
XFHB_RS08950	COG2264	protein methyltransferase activity
XFHB_RS08960	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
XFHB_RS08965	COG0277	FAD linked oxidase domain protein
XFHB_RS08970	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
XFHB_RS08975	COG0531	amino acid
XFHB_RS08980	COG0531	amino acid
XFHB_RS08985	COG0235	Class ii aldolase
XFHB_RS08990	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
XFHB_RS08995	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
XFHB_RS09000	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
XFHB_RS09000	COG0140	phosphoribosyl-ATP diphosphatase activity
XFHB_RS09010	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
XFHB_RS09020	COG0131	Imidazoleglycerol-phosphate dehydratase
XFHB_RS09020	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
XFHB_RS09030	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
XFHB_RS09035	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
XFHB_RS09045	COG0124	histidyl-tRNA synthetase
XFHB_RS09055	COG0083	homoserine kinase activity
XFHB_RS09060	COG0460	homoserine dehydrogenase
XFHB_RS09060	COG0527	aspartate kinase activity
XFHB_RS09065	COG0540	Belongs to the ATCase OTCase family
XFHB_RS09075	COG1678	Uncharacterized ACR, COG1678
XFHB_RS09085	COG1686	Belongs to the peptidase S11 family
XFHB_RS09095	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
XFHB_RS09110	COG4953	penicillin-binding protein 1C
XFHB_RS09140	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
XFHB_RS09145	COG0481	GTPase activity
XFHB_RS09160	COG0571	ribonuclease III activity
XFHB_RS09165	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
XFHB_RS09175	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
XFHB_RS09180	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
XFHB_RS09190	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
XFHB_RS09195	COG1971	Probably functions as a manganese efflux pump
XFHB_RS09210	COG0823	Involved in the tonB-independent uptake of proteins
XFHB_RS09210	COG1506	peptidase
XFHB_RS09215	COG1297	OPT oligopeptide transporter protein
XFHB_RS09235	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
XFHB_RS09245	COG0676	glucose-6-phosphate 1-epimerase activity
XFHB_RS09255	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
XFHB_RS09260	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
XFHB_RS09270	COG0318	PFAM AMP-dependent synthetase and ligase
XFHB_RS09280	COG0463	Glycosyl transferase, family 2
XFHB_RS09290	COG1475	DNA binding
XFHB_RS09295	COG1192	Involved in chromosome partitioning
XFHB_RS09305	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
XFHB_RS09365	COG1643	Atp-dependent helicase
XFHB_RS09370	COG0783	Belongs to the Dps family
XFHB_RS09385	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
XFHB_RS09420	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
XFHB_RS09430	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
XFHB_RS09435	COG2890	protein-(glutamine-N5) methyltransferase activity
XFHB_RS09440	COG1999	signal sequence binding
XFHB_RS09455	COG0741	lytic transglycosylase activity
XFHB_RS09460	COG0617	tRNA 3'-terminal CCA addition
XFHB_RS09465	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
XFHB_RS09480	COG0156	8-amino-7-oxononanoate synthase activity
XFHB_RS09485	COG2267	carboxylic ester hydrolase activity
XFHB_RS09495	COG1846	Transcriptional regulator
XFHB_RS09505	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
XFHB_RS09515	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
XFHB_RS09520	COG4208	sulfate ABC transporter
XFHB_RS09525	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
XFHB_RS09540	COG3142	Participates in the control of copper homeostasis
XFHB_RS09550	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
XFHB_RS09555	COG0259	pyridoxamine-phosphate oxidase activity
XFHB_RS09565	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
XFHB_RS09570	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
XFHB_RS09580	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
XFHB_RS09595	COG2353	YceI-like domain
XFHB_RS09600	COG3038	cytochrome b561
XFHB_RS09610	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
XFHB_RS09635	COG2894	cell division
XFHB_RS09655	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
XFHB_RS09660	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
XFHB_RS09665	COG0772	Belongs to the SEDS family
XFHB_RS09670	COG0768	penicillin binding
XFHB_RS09675	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
XFHB_RS09680	COG1792	Involved in formation and maintenance of cell shape
XFHB_RS09685	COG1077	Cell shape determining protein MreB Mrl
XFHB_RS09730	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
XFHB_RS09735	COG1127	ABC transporter
XFHB_RS09740	COG3218	ABC-type transport auxiliary lipoprotein component
XFHB_RS09740	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
XFHB_RS09755	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
XFHB_RS09755	COG0644	oxidoreductase
XFHB_RS09765	COG2840	Smr protein MutS2
XFHB_RS09770	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
XFHB_RS09775	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
XFHB_RS09780	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
XFHB_RS09785	COG0148	phosphopyruvate hydratase activity
XFHB_RS09790	COG2877	3-deoxy-8-phosphooctulonate synthase activity
XFHB_RS09795	COG0504	CTP synthase activity
XFHB_RS09825	COG1253	flavin adenine dinucleotide binding
XFHB_RS09830	COG2733	membrane
XFHB_RS09850	COG2921	Belongs to the UPF0250 family
XFHB_RS09855	COG0321	lipoyl(octanoyl) transferase activity
XFHB_RS09860	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
XFHB_RS09865	COG5297	Belongs to the glycosyl hydrolase family 6
XFHB_RS09895	COG0668	transmembrane transport
XFHB_RS09900	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
XFHB_RS09915	COG2373	Large extracellular alpha-helical protein
XFHB_RS10060	COG0582	viral genome integration into host DNA
XFHB_RS10075	COG2911	Protein conserved in bacteria
XFHB_RS10080	COG0729	surface antigen
XFHB_RS10085	COG1956	GAF domain-containing protein
XFHB_RS10090	COG1643	Atp-dependent helicase
XFHB_RS10115	COG1131	(ABC) transporter
XFHB_RS10120	COG0842	Transport permease protein
XFHB_RS10160	COG1217	gtp-binding protein TYPA
XFHB_RS10165	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
XFHB_RS10170	COG0039	L-malate dehydrogenase activity
XFHB_RS10175	COG0625	glutathione transferase activity
XFHB_RS10180	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XFHB_RS10235	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
XFHB_RS10240	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
XFHB_RS10285	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
XFHB_RS10290	COG0740	serine-type endopeptidase activity
XFHB_RS10295	COG0544	peptidyl-prolyl cis-trans isomerase activity
XFHB_RS10310	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
XFHB_RS10320	COG5380	lipid catabolic process
XFHB_RS10330	COG0606	chelatase, subunit chli
XFHB_RS10335	COG2960	long-chain fatty acid transporting porin activity
XFHB_RS10340	COG0203	ribosomal protein L17
XFHB_RS10350	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
XFHB_RS10355	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
XFHB_RS10360	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
XFHB_RS10365	COG0201	protein transport
XFHB_RS10370	COG0200	Binds to the 23S rRNA
XFHB_RS10375	COG1841	ribosomal large subunit assembly
XFHB_RS10380	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
XFHB_RS10390	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
XFHB_RS10395	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
XFHB_RS10400	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
XFHB_RS10405	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
XFHB_RS10410	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
XFHB_RS10420	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
XFHB_RS10425	COG0255	Belongs to the universal ribosomal protein uL29 family
XFHB_RS10435	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
XFHB_RS10440	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
XFHB_RS10445	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
XFHB_RS10450	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
XFHB_RS10455	COG0089	rRNA binding
XFHB_RS10460	COG0088	Forms part of the polypeptide exit tunnel
XFHB_RS10465	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
XFHB_RS10480	COG0356	it plays a direct role in the translocation of protons across the membrane
XFHB_RS10490	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
XFHB_RS10495	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
XFHB_RS10500	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
XFHB_RS10505	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
XFHB_RS10510	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
XFHB_RS10515	COG0355	proton-transporting ATP synthase activity, rotational mechanism
XFHB_RS10525	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
XFHB_RS10540	COG1064	alcohol dehydrogenase
XFHB_RS10555	COG0583	DNA-binding transcription factor activity
XFHB_RS10560	COG0312	modulator of DNA gyrase
XFHB_RS10565	COG3028	Belongs to the UPF0307 family
XFHB_RS10570	COG0312	modulator of DNA gyrase
XFHB_RS10585	COG0424	maF-like protein
XFHB_RS10600	COG0494	nUDIX hydrolase
XFHB_RS10610	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
XFHB_RS10620	COG0019	diaminopimelate decarboxylase activity
XFHB_RS10625	COG1024	Enoyl-CoA hydratase
XFHB_RS10640	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
XFHB_RS10645	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
XFHB_RS10650	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
XFHB_RS10660	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
XFHB_RS10665	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
XFHB_RS10670	COG0505	Belongs to the CarA family
XFHB_RS10675	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
XFHB_RS10700	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
XFHB_RS10730	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XFHB_RS10750	COG1663	tetraacyldisaccharide 4'-kinase activity
XFHB_RS10755	COG1132	(ABC) transporter
XFHB_RS10765	COG0811	peptide transport
XFHB_RS10775	COG1136	(ABC) transporter
XFHB_RS10795	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
XFHB_RS10805	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
XFHB_RS10810	COG2009	succinate dehydrogenase
XFHB_RS10825	COG3842	ATPase activity
XFHB_RS10830	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
XFHB_RS10835	COG0837	glucose binding
XFHB_RS10840	COG0363	glucosamine-6-phosphate deaminase activity
XFHB_RS10875	COG0528	UMP kinase activity
XFHB_RS10900	COG2067	long-chain fatty acid transport protein
XFHB_RS10905	COG0233	cytoplasmic translational termination
XFHB_RS10910	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
XFHB_RS10915	COG0575	Belongs to the CDS family
XFHB_RS10925	COG0750	zinc metalloprotease
XFHB_RS10935	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XFHB_RS10940	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
XFHB_RS10945	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XFHB_RS10950	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XFHB_RS10955	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
XFHB_RS11015	COG1946	Acyl-CoA thioesterase
XFHB_RS11025	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
XFHB_RS11035	COG1914	H( )-stimulated, divalent metal cation uptake system
XFHB_RS11080	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
XFHB_RS11085	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
XFHB_RS11090	COG0165	Argininosuccinate lyase
XFHB_RS11095	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
XFHB_RS11100	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
XFHB_RS11105	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
XFHB_RS11110	COG0137	argininosuccinate synthase activity
XFHB_RS11115	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
XFHB_RS11130	COG0215	cysteine-tRNA ligase activity
XFHB_RS11135	COG2166	iron-sulfur cluster assembly
XFHB_RS11155	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
XFHB_RS11160	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
XFHB_RS11180	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
XFHB_RS11190	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
XFHB_RS11195	COG0742	ribosomal rna small subunit methyltransferase
XFHB_RS11200	COG0326	Molecular chaperone. Has ATPase activity
XFHB_RS11205	COG0281	malic enzyme
XFHB_RS11205	COG0280	phosphate acetyltransferase
XFHB_RS11210	COG1301	dicarboxylic acid transport
XFHB_RS11260	COG0556	nucleotide-excision repair
XFHB_RS11285	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
XFHB_RS11310	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
XFHB_RS11315	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
XFHB_RS11335	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
XFHB_RS11335	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
XFHB_RS11340	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
XFHB_RS11350	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
XFHB_RS11355	COG0488	(ABC) transporter
XFHB_RS11360	COG0579	oxidoreductase
XFHB_RS11365	COG3011	Protein conserved in bacteria
XFHB_RS11370	COG1496	oxidoreductase activity
XFHB_RS11375	COG0564	pseudouridine synthase activity
XFHB_RS11380	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XFHB_RS11390	COG1918	ferrous iron import across plasma membrane
XFHB_RS11390	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
XFHB_RS11405	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
XFHB_RS11415	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
XFHB_RS11430	COG0758	DNA mediated transformation
XFHB_RS11435	COG2922	Belongs to the Smg family
XFHB_RS11445	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
XFHB_RS11445	COG1754	DNA topoisomerase type I activity
XFHB_RS11450	COG0009	L-threonylcarbamoyladenylate synthase
XFHB_RS11480	COG2969	positive regulation of protein catabolic process
XFHB_RS11485	COG0625	glutathione transferase activity
XFHB_RS11490	COG2857	Cytochrome c1
XFHB_RS11495	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
XFHB_RS11500	COG0723	plastoquinol--plastocyanin reductase activity
XFHB_RS11510	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
XFHB_RS11515	COG1702	phosphate starvation-inducible protein PhoH
XFHB_RS11520	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
XFHB_RS11530	COG4535	Mg2 and Co2 transporter CorC
XFHB_RS11625	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
XFHB_RS11635	COG1199	ATP-dependent helicase activity
XFHB_RS11645	COG0288	reversible hydration of carbon dioxide
XFHB_RS11670	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
XFHB_RS11675	COG2011	ABC-type metal ion transport system permease component
XFHB_RS11680	COG1464	Belongs to the NlpA lipoprotein family
XFHB_RS11695	COG0508	dehydrogenase complex catalyzes the overall conversion of
XFHB_RS11700	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
XFHB_RS11715	COG0626	cystathionine gamma-synthase activity
XFHB_RS11720	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
XFHB_RS11725	COG0739	heme binding
XFHB_RS11740	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
XFHB_RS11745	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
XFHB_RS11750	COG1238	metal cluster binding
XFHB_RS11765	COG5002	protein histidine kinase activity
XFHB_RS11775	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
XFHB_RS11780	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XFHB_RS11785	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
XFHB_RS11790	COG3858	chitin binding
XFHB_RS11790	COG1388	LysM domain
XFHB_RS11795	COG3525	Glycosyl hydrolase, family 20, catalytic domain
XFHB_RS11805	COG1472	Belongs to the glycosyl hydrolase 3 family
XFHB_RS11820	COG3537	Alpha-1,2-mannosidase
XFHB_RS11830	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
XFHB_RS11835	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
XFHB_RS11840	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
XFHB_RS11850	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XFHB_RS11855	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XFHB_RS11860	COG0583	DNA-binding transcription factor activity
XFHB_RS11895	COG3588	fructose-bisphosphate aldolase
XFHB_RS11905	COG0469	pyruvate kinase activity
XFHB_RS11915	COG0126	phosphoglycerate kinase activity
XFHB_RS11920	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
XFHB_RS11925	COG0735	belongs to the Fur family
XFHB_RS11935	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XFHB_RS11935	COG5297	Belongs to the glycosyl hydrolase family 6
XFHB_RS11945	COG0612	Peptidase, M16
XFHB_RS11960	COG4305	rare lipoprotein A
XFHB_RS11965	COG0653	protein targeting
XFHB_RS11970	COG0739	heme binding
XFHB_RS11980	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
XFHB_RS11990	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
XFHB_RS12000	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
XFHB_RS12005	COG1181	Belongs to the D-alanine--D-alanine ligase family
XFHB_RS12010	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
XFHB_RS12015	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
XFHB_RS12025	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
XFHB_RS12030	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
XFHB_RS12035	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
XFHB_RS12045	COG3116	cell division
XFHB_RS12050	COG0275	rRNA processing
XFHB_RS12070	COG0471	metal ion transport
XFHB_RS12070	COG3273	potassium ion transport
XFHB_RS12075	COG0220	tRNA (guanine-N7-)-methyltransferase activity
XFHB_RS12080	COG2022	thiamine diphosphate biosynthetic process
XFHB_RS12110	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
XFHB_RS12110	COG2755	lipolytic protein G-D-S-L family
XFHB_RS12140	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
XFHB_RS12165	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
XFHB_RS12165	COG3453	Protein conserved in bacteria
XFHB_RS12170	COG0640	Transcriptional regulator
XFHB_RS12175	COG2391	methyltransferase activity
XFHB_RS12180	COG2391	methyltransferase activity
XFHB_RS12185	COG0730	response to heat
XFHB_RS12190	COG0717	Belongs to the dCTP deaminase family
XFHB_RS12200	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
XFHB_RS12205	COG0860	N-Acetylmuramoyl-L-alanine amidase
XFHB_RS12210	COG0802	atpase or kinase
XFHB_RS12215	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
XFHB_RS12215	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
XFHB_RS12225	COG1570	exodeoxyribonuclease VII activity
XFHB_RS12250	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
XFHB_RS12270	COG0776	regulation of translation
XFHB_RS12275	COG0072	phenylalanine-tRNA ligase activity
XFHB_RS12275	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
XFHB_RS12280	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
XFHB_RS12285	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
XFHB_RS12295	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
XFHB_RS12300	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
XFHB_RS12365	COG3077	Addiction module antitoxin, RelB DinJ family
XFHB_RS12440	COG3772	lysozyme
XFHB_RS12550	COG3617	BRO family, N-terminal domain
XFHB_RS12600	COG0745	RESPONSE REGULATOR receiver
XFHB_RS12605	COG0642	Histidine kinase
XFHB_RS12610	COG0237	dephospho-CoA kinase activity
XFHB_RS12615	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
XFHB_RS12665	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
XFHB_RS12680	COG2831	hemolysin activation secretion protein
XFHB_RS12705	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
XFHB_RS12715	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
XFHB_RS12720	COG3115	cell septum assembly
XFHB_RS12730	COG0359	binds to the 23S rRNA
XFHB_RS12735	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
XFHB_RS12745	COG0316	Belongs to the HesB IscA family
XFHB_RS12750	COG0017	Asparaginyl-tRNA synthetase
XFHB_RS12780	COG0167	dihydroorotate dehydrogenase activity
XFHB_RS12785	COG0812	UDP-N-acetylmuramate dehydrogenase activity
XFHB_RS12790	COG0697	spore germination
XFHB_RS12800	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
XFHB_RS12815	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
XFHB_RS12820	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
XFHB_RS12835	COG1132	(ABC) transporter
XFHB_RS12845	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
XFHB_RS12850	COG1538	Outer membrane efflux protein
XFHB_RS12855	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XFHB_RS12870	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
XFHB_RS12885	COG4783	chaperone-mediated protein folding
XFHB_RS12895	COG0473	3-isopropylmalate dehydrogenase activity
XFHB_RS12905	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
XFHB_RS12915	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
XFHB_RS12925	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
XFHB_RS12925	COG0316	Belongs to the HesB IscA family
XFHB_RS12930	COG2154	pterin-4-alpha-carbinolamine dehydratase
XFHB_RS12940	COG0564	pseudouridine synthase activity
XFHB_RS12945	COG1530	ribonuclease E activity
XFHB_RS12950	COG2197	response regulator
XFHB_RS12955	COG1054	Belongs to the UPF0176 family
XFHB_RS12970	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
XFHB_RS12985	COG0488	(ABC) transporter
XFHB_RS12995	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
XFHB_RS13000	COG1278	Cold shock
XFHB_RS13010	COG0501	Belongs to the peptidase M48B family
XFHB_RS13020	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
XFHB_RS13025	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
XFHB_RS13030	COG0049	tRNA binding
XFHB_RS13040	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
XFHB_RS13045	COG0085	RNA polymerase activity
XFHB_RS13050	COG0222	ribosome binding
XFHB_RS13055	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
XFHB_RS13060	COG0081	regulation of translation
XFHB_RS13065	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
XFHB_RS13070	COG0250	Participates in transcription elongation, termination and antitermination
XFHB_RS13075	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
XFHB_RS13085	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
XFHB_RS13105	COG0012	GTP binding
XFHB_RS13110	COG0193	aminoacyl-tRNA hydrolase activity
XFHB_RS13120	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
XFHB_RS13130	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
XFHB_RS13135	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
XFHB_RS13145	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
XFHB_RS13150	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
XFHB_RS13160	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
XFHB_RS13160	COG0116	Belongs to the methyltransferase superfamily
XFHB_RS13215	COG2095	MarC family integral membrane protein
XFHB_RS13225	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
XFHB_RS13240	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
XFHB_RS13265	COG0210	DNA helicase
XFHB_RS13270	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
XFHB_RS13275	COG0616	signal peptide processing
XFHB_RS13300	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
XFHB_RS13310	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
XFHB_RS13315	COG2201	protein-glutamate methylesterase activity
XFHB_RS13320	COG2177	Part of the ABC transporter FtsEX involved in
XFHB_RS13325	COG2884	Cell division ATP-binding protein ftsE
XFHB_RS13330	COG0513	Belongs to the DEAD box helicase family
XFHB_RS13335	COG3118	belongs to the thioredoxin family
XFHB_RS13340	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
XFHB_RS13355	COG0793	Belongs to the peptidase S41A family
XFHB_RS13360	COG4942	peptidase
XFHB_RS13375	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XFHB_RS13380	COG0493	'glutamate synthase
XFHB_RS13385	COG0070	glutamate synthase
XFHB_RS13385	COG0069	glutamate synthase activity
XFHB_RS13385	COG0067	glutamate synthase
XFHB_RS13420	COG1028	Short-chain dehydrogenase reductase Sdr
XFHB_RS13445	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
XFHB_RS13470	COG0732	type I restriction modification DNA specificity domain
XFHB_RS13500	COG1280	lysine exporter protein (LysE YggA)
XFHB_RS13545	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
XFHB_RS13560	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
XFHB_RS13660	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
XFHB_RS13665	COG3657	addiction module killer protein
XFHB_RS13725	COG3210	domain, Protein
XFHB_RS13730	COG3210	domain, Protein
XFHB_RS13745	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
XFHB_RS13755	COG0706	membrane insertase activity
XFHB_RS13760	COG0594	ribonuclease P activity
XFHB_RS13815	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
XFHB_RS13815	COG0551	DNA topoisomerase type I activity
XFHB_RS13950	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
XFHB_RS13980	COG1475	DNA binding
XFHB_RS14005	COG1192	Involved in chromosome partitioning