locus-tag	class	description
OY18_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
OY18_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
OY18_RS00025	COG0187	DNA topoisomerase II activity
OY18_RS00035	COG0501	Belongs to the peptidase M48B family
OY18_RS00075	COG0408	coproporphyrinogen oxidase activity
OY18_RS00100	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
OY18_RS00115	COG4969	Belongs to the N-Me-Phe pilin family
OY18_RS00180	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
OY18_RS00190	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
OY18_RS00200	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
OY18_RS00205	COG0511	ligase activity, forming carbon-carbon bonds
OY18_RS00210	COG0439	Biotin carboxylase
OY18_RS00215	COG0210	DNA helicase
OY18_RS00230	COG1017	nitric oxide dioxygenase activity
OY18_RS00230	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
OY18_RS00245	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
OY18_RS00255	COG1040	competence protein
OY18_RS00260	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
OY18_RS00265	COG1752	Esterase of the alpha-beta hydrolase superfamily
OY18_RS00275	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
OY18_RS00310	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
OY18_RS00320	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
OY18_RS00350	COG3121	Chaperone
OY18_RS00355	COG3539	Fimbrial protein
OY18_RS00360	COG1546	Belongs to the CinA family
OY18_RS00365	COG0477	Major facilitator Superfamily
OY18_RS00370	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
OY18_RS00375	COG1923	regulation of RNA biosynthetic process
OY18_RS00380	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
OY18_RS00385	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
OY18_RS00395	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
OY18_RS00405	COG1534	Rna-binding protein
OY18_RS00415	COG0129	dihydroxy-acid dehydratase activity
OY18_RS00440	COG1560	Kdo2-lipid A biosynthetic process
OY18_RS00445	COG1519	Transferase
OY18_RS00455	COG0228	four-way junction DNA binding
OY18_RS00460	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
OY18_RS00465	COG0336	Belongs to the RNA methyltransferase TrmD family
OY18_RS00470	COG0335	large ribosomal subunit rRNA binding
OY18_RS00490	COG2171	N-acyltransferase activity
OY18_RS00495	COG1393	Belongs to the ArsC family
OY18_RS00500	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
OY18_RS00505	COG0367	asparagine synthase
OY18_RS00515	COG2070	2-Nitropropane dioxygenase
OY18_RS00520	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
OY18_RS00525	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
OY18_RS00545	COG0339	signal peptide processing
OY18_RS00560	COG2132	Multicopper oxidase
OY18_RS00570	COG0525	valine-tRNA ligase activity
OY18_RS00590	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
OY18_RS00610	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
OY18_RS00620	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
OY18_RS00625	COG1166	arginine decarboxylase activity
OY18_RS00630	COG4221	oxidoreductase activity
OY18_RS00640	COG0018	arginyl-trna synthetase
OY18_RS00645	COG2003	Belongs to the UPF0758 family
OY18_RS00650	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
OY18_RS00660	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
OY18_RS00670	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
OY18_RS00715	COG2223	nitrite transmembrane transporter activity
OY18_RS00720	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
OY18_RS00725	COG0739	heme binding
OY18_RS00730	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
OY18_RS00760	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
OY18_RS00780	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
OY18_RS00785	COG1272	protein, Hemolysin III
OY18_RS00790	COG0463	Glycosyl transferase, family 2
OY18_RS00795	COG0084	hydrolase, TatD family'
OY18_RS00810	COG0509	glycine decarboxylation via glycine cleavage system
OY18_RS00815	COG0404	The glycine cleavage system catalyzes the degradation of glycine
OY18_RS00825	COG0330	HflC and HflK could
OY18_RS00830	COG3956	TIGRFAM MazG family protein
OY18_RS00835	COG1218	3'(2'),5'-bisphosphate nucleotidase
OY18_RS00840	COG0494	nUDIX hydrolase
OY18_RS00850	COG1385	rRNA (uridine-N3-)-methyltransferase activity
OY18_RS00860	COG0513	Belongs to the DEAD box helicase family
OY18_RS00865	COG0720	synthase
OY18_RS00900	COG1981	membrane
OY18_RS00905	COG0825	malonyl-CoA metabolic process
OY18_RS00910	COG0587	DNA-directed DNA polymerase activity
OY18_RS00940	COG0512	Glutamine amidotransferase of anthranilate synthase
OY18_RS00945	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
OY18_RS00950	COG0134	indole-3-glycerol-phosphate synthase activity
OY18_RS00975	COG0006	proline dipeptidase activity
OY18_RS00990	COG0343	queuine tRNA-ribosyltransferase activity
OY18_RS00995	COG1862	Preprotein translocase
OY18_RS01000	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
OY18_RS01005	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
OY18_RS01015	COG0617	tRNA 3'-terminal CCA addition
OY18_RS01025	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
OY18_RS01030	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
OY18_RS01035	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
OY18_RS01040	COG0166	Belongs to the GPI family
OY18_RS01055	COG0779	Required for maturation of 30S ribosomal subunits
OY18_RS01060	COG0195	Participates in both transcription termination and antitermination
OY18_RS01065	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
OY18_RS01070	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
OY18_RS01075	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
OY18_RS01085	COG1185	polyribonucleotide nucleotidyltransferase activity
OY18_RS01090	COG1733	regulation of RNA biosynthetic process
OY18_RS01095	COG0702	epimerase
OY18_RS01185	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
OY18_RS01215	COG0477	Major facilitator Superfamily
OY18_RS01230	COG0563	adenylate kinase activity
OY18_RS01235	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
OY18_RS01240	COG0671	phosphoesterase, PA-phosphatase related
OY18_RS01250	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
OY18_RS01255	COG0628	permease
OY18_RS01275	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
OY18_RS01280	COG1090	epimerase
OY18_RS01310	COG1049	propionate catabolic process, 2-methylcitrate cycle
OY18_RS01380	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
OY18_RS01390	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
OY18_RS01400	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
OY18_RS01405	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
OY18_RS01410	COG1034	ATP synthesis coupled electron transport
OY18_RS01430	COG0713	ATP synthesis coupled electron transport
OY18_RS01445	COG1007	ATP synthesis coupled electron transport
OY18_RS01450	COG1028	Short-chain dehydrogenase reductase Sdr
OY18_RS01455	COG2851	Citrate transporter
OY18_RS01470	COG0642	Histidine kinase
OY18_RS01490	COG0675	Transposase, IS605 OrfB family
OY18_RS01525	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
OY18_RS01530	COG4206	TonB-dependent receptor
OY18_RS01535	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
OY18_RS01555	COG0277	FAD linked oxidase domain protein
OY18_RS01560	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
OY18_RS01570	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
OY18_RS01575	COG2124	cytochrome p450
OY18_RS01590	COG0305	Participates in initiation and elongation during chromosome replication
OY18_RS01605	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
OY18_RS01610	COG0667	Aldo Keto reductase
OY18_RS01615	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
OY18_RS01650	COG2194	sulfuric ester hydrolase activity
OY18_RS01655	COG2124	cytochrome p450
OY18_RS01660	COG0352	thiamine-phosphate diphosphorylase activity
OY18_RS01690	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
OY18_RS01715	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
OY18_RS01730	COG0494	nUDIX hydrolase
OY18_RS01740	COG2193	ferroxidase activity
OY18_RS01755	COG3850	Histidine kinase
OY18_RS01755	COG3437	response regulator, receiver
OY18_RS01755	COG4999	Histidine kinase
OY18_RS01755	COG2205	protein histidine kinase activity
OY18_RS01790	COG0861	Integral membrane protein TerC family
OY18_RS01795	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
OY18_RS01800	COG0531	amino acid
OY18_RS01810	COG1116	anion transmembrane transporter activity
OY18_RS01815	COG1322	Protein conserved in bacteria
OY18_RS01825	COG2853	Lipoprotein
OY18_RS01840	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
OY18_RS01845	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
OY18_RS01850	COG1127	ABC transporter
OY18_RS01855	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
OY18_RS01860	COG1074	ATP-dependent DNA helicase activity
OY18_RS01880	COG0180	Tryptophanyl-tRNA synthetase
OY18_RS01885	COG0358	DNA primase activity
OY18_RS01895	COG1610	YqeY-like protein
OY18_RS01905	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
OY18_RS01910	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
OY18_RS01915	COG0668	transmembrane transport
OY18_RS01935	COG1183	phosphatidylcholine synthase activity
OY18_RS01945	COG0442	prolyl-tRNA aminoacylation
OY18_RS01965	COG0604	alcohol dehydrogenase
OY18_RS01970	COG0330	HflC and HflK could
OY18_RS01975	COG0330	HflC and HflK could
OY18_RS01985	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
OY18_RS01990	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
OY18_RS01995	COG0105	UTP biosynthetic process
OY18_RS02000	COG0820	rRNA (adenine-C2-)-methyltransferase activity
OY18_RS02020	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
OY18_RS02025	COG1160	GTP binding
OY18_RS02030	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
OY18_RS02045	COG4943	cyclic-guanylate-specific phosphodiesterase activity
OY18_RS02050	COG1611	Belongs to the LOG family
OY18_RS02055	COG4968	Prepilin-type N-terminal cleavage methylation domain
OY18_RS02100	COG0629	single-stranded DNA binding
OY18_RS02120	COG4969	Belongs to the N-Me-Phe pilin family
OY18_RS02250	COG0740	serine-type endopeptidase activity
OY18_RS02265	COG3772	lysozyme
OY18_RS02310	COG5449	Phage conserved hypothetical protein BR0599
OY18_RS02435	COG2878	Part of a membrane complex involved in electron transport
OY18_RS02450	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
OY18_RS02455	COG3107	peptidoglycan biosynthetic process
OY18_RS02460	COG0792	nuclease activity
OY18_RS02465	COG1162	GTPase activity
OY18_RS02470	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
OY18_RS02485	COG0519	Catalyzes the synthesis of GMP from XMP
OY18_RS02485	COG0518	GMP synthase (glutamine-hydrolyzing) activity
OY18_RS02500	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
OY18_RS02505	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
OY18_RS02515	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
OY18_RS02525	COG2974	May be involved in recombination
OY18_RS02530	COG0037	tRNA processing
OY18_RS02540	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
OY18_RS02560	COG3590	peptidase
OY18_RS02590	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
OY18_RS02600	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
OY18_RS02610	COG0628	permease
OY18_RS02620	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
OY18_RS02625	COG3178	'Phosphotransferase
OY18_RS02630	COG1555	photosystem II stabilization
OY18_RS02635	COG1477	protein flavinylation
OY18_RS02660	COG4774	siderophore transport
OY18_RS02680	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
OY18_RS02695	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
OY18_RS02705	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
OY18_RS02730	COG0459	protein refolding
OY18_RS02740	COG1324	tolerance protein
OY18_RS02750	COG0351	phosphomethylpyrimidine kinase
OY18_RS02750	COG0352	thiamine-phosphate diphosphorylase activity
OY18_RS02760	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
OY18_RS02865	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
OY18_RS02880	COG2311	Membrane
OY18_RS02890	COG0791	NLP P60 protein
OY18_RS02895	COG0791	NLP P60 protein
OY18_RS02905	COG1301	dicarboxylic acid transport
OY18_RS02915	COG0037	tRNA processing
OY18_RS02920	COG1722	exodeoxyribonuclease VII activity
OY18_RS02925	COG0142	geranyltranstransferase activity
OY18_RS02965	COG1028	Short-chain dehydrogenase reductase Sdr
OY18_RS02980	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
OY18_RS02985	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
OY18_RS03010	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
OY18_RS03015	COG0483	inositol monophosphate 1-phosphatase activity
OY18_RS03025	COG1509	lysine 2,3-aminomutase activity
OY18_RS03035	COG0402	S-adenosylhomocysteine deaminase activity
OY18_RS03040	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
OY18_RS03045	COG0546	phosphoglycolate phosphatase activity
OY18_RS03065	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
OY18_RS03090	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
OY18_RS03100	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
OY18_RS03120	COG4133	protoheme IX ABC transporter activity
OY18_RS03125	COG0436	Aminotransferase
OY18_RS03140	COG1187	pseudouridine synthase activity
OY18_RS03145	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
OY18_RS03150	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
OY18_RS03175	COG1175	transmembrane transport
OY18_RS03180	COG0395	ABC-type sugar transport system, permease component
OY18_RS03225	COG0776	regulation of translation
OY18_RS03235	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
OY18_RS03250	COG1210	Utp--glucose-1-phosphate uridylyltransferase
OY18_RS03255	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
OY18_RS03265	COG0518	GMP synthase (glutamine-hydrolyzing) activity
OY18_RS03265	COG0519	Catalyzes the synthesis of GMP from XMP
OY18_RS03280	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
OY18_RS03285	COG0261	This protein binds to 23S rRNA in the presence of protein L20
OY18_RS03290	COG0211	Belongs to the bacterial ribosomal protein bL27 family
OY18_RS03295	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
OY18_RS03300	COG0268	Binds directly to 16S ribosomal RNA
OY18_RS03305	COG0728	peptidoglycan biosynthetic process
OY18_RS03310	COG0196	riboflavin kinase activity
OY18_RS03315	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
OY18_RS03320	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
OY18_RS03360	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
OY18_RS03360	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
OY18_RS03430	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
OY18_RS03450	COG1064	alcohol dehydrogenase
OY18_RS03465	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
OY18_RS03470	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
OY18_RS03475	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
OY18_RS03475	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
OY18_RS03495	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
OY18_RS03500	COG0066	3-isopropylmalate dehydratase activity
OY18_RS03505	COG0473	3-isopropylmalate dehydrogenase activity
OY18_RS03535	COG0438	transferase activity, transferring glycosyl groups
OY18_RS03550	COG0438	transferase activity, transferring glycosyl groups
OY18_RS03555	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
OY18_RS03560	COG0745	RESPONSE REGULATOR receiver
OY18_RS03565	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
OY18_RS03570	COG2954	triphosphatase activity
OY18_RS03575	COG1472	Belongs to the glycosyl hydrolase 3 family
OY18_RS03580	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
OY18_RS03590	COG1278	Cold shock
OY18_RS03600	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
OY18_RS03610	COG2914	Belongs to the UPF0125 (RnfH) family
OY18_RS03615	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
OY18_RS03625	COG0497	DNA recombination
OY18_RS03635	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
OY18_RS03640	COG0443	Heat shock 70 kDa protein
OY18_RS03645	COG0484	heat shock protein binding
OY18_RS03650	COG1605	Chorismate mutase
OY18_RS03650	COG0287	Prephenate dehydrogenase
OY18_RS03670	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
OY18_RS03675	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
OY18_RS03680	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
OY18_RS03695	COG4555	ABC transporter
OY18_RS03700	COG1668	transmembrane transport
OY18_RS03710	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
OY18_RS03715	COG1605	Chorismate mutase
OY18_RS03715	COG0077	Prephenate dehydratase
OY18_RS03720	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
OY18_RS03760	COG3772	lysozyme
OY18_RS03775	COG0322	excinuclease ABC activity
OY18_RS03780	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
OY18_RS03820	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
OY18_RS03825	COG0489	protein tyrosine kinase activity
OY18_RS03830	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
OY18_RS03835	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
OY18_RS03865	COG3617	BRO family, N-terminal domain
OY18_RS03930	COG4197	protein conserved in bacteria, prophage-related
OY18_RS03975	COG3772	lysozyme
OY18_RS04000	COG5410	chromosome segregation
OY18_RS04005	COG3567	Phage-associated protein, HI1409 family
OY18_RS04020	COG2369	cell adhesion
OY18_RS04100	COG2026	Addiction module toxin, RelE StbE family
OY18_RS04135	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
OY18_RS04140	COG3657	addiction module killer protein
OY18_RS04210	COG3617	BRO family, N-terminal domain
OY18_RS04395	COG2944	sequence-specific DNA binding
OY18_RS04410	COG3077	Addiction module antitoxin, RelB DinJ family
OY18_RS04480	COG0629	single-stranded DNA binding
OY18_RS04505	COG5532	Uncharacterized conserved protein (DUF2303)
OY18_RS04600	COG3617	BRO family, N-terminal domain
OY18_RS04615	COG0305	Participates in initiation and elongation during chromosome replication
OY18_RS04620	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
OY18_RS04630	COG3772	lysozyme
OY18_RS04775	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
OY18_RS04795	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
OY18_RS04815	COG1959	2 iron, 2 sulfur cluster binding
OY18_RS04820	COG0719	Fe-S assembly protein
OY18_RS04825	COG0396	ATPase activity
OY18_RS04835	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
OY18_RS04850	COG0297	glycogen (starch) synthase activity
OY18_RS04855	COG0726	polysaccharide deacetylase
OY18_RS04860	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
OY18_RS04865	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
OY18_RS04870	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
OY18_RS04875	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
OY18_RS04880	COG1609	Transcriptional regulator
OY18_RS04895	COG0837	glucose binding
OY18_RS04910	COG1028	Short-chain dehydrogenase reductase Sdr
OY18_RS04915	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
OY18_RS04920	COG4191	Histidine kinase
OY18_RS04925	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
OY18_RS04930	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
OY18_RS04935	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
OY18_RS04945	COG1674	ftsk spoiiie
OY18_RS04950	COG0492	ferredoxin-NADP+ reductase activity
OY18_RS04960	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
OY18_RS04965	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
OY18_RS04975	COG0542	response to heat
OY18_RS04980	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
OY18_RS04995	COG2915	High frequency lysogenization protein hflD homolog
OY18_RS05005	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
OY18_RS05030	COG0218	Necessary for normal cell division and for the maintenance of normal septation
OY18_RS05040	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
OY18_RS05045	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
OY18_RS05050	COG4974	Belongs to the 'phage' integrase family
OY18_RS05055	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
OY18_RS05095	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
OY18_RS05100	COG0271	Belongs to the BolA IbaG family
OY18_RS05110	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
OY18_RS05125	COG1137	ATPase activity
OY18_RS05145	COG1660	Displays ATPase and GTPase activities
OY18_RS05155	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
OY18_RS05180	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
OY18_RS05185	COG0629	single-stranded DNA binding
OY18_RS05190	COG0142	geranyltranstransferase activity
OY18_RS05195	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
OY18_RS05200	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
OY18_RS05205	COG1845	cytochrome c oxidase, subunit III
OY18_RS05210	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
OY18_RS05215	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
OY18_RS05215	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
OY18_RS05230	COG1643	Atp-dependent helicase
OY18_RS05235	COG0783	Belongs to the Dps family
OY18_RS05240	COG0514	ATP-dependent DNA helicase (RecQ)
OY18_RS05250	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
OY18_RS05260	COG0159	tryptophan synthase activity
OY18_RS05265	COG0133	tryptophan synthase activity
OY18_RS05270	COG0135	phosphoribosylanthranilate isomerase activity
OY18_RS05275	COG0101	tRNA pseudouridine synthase activity
OY18_RS05285	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
OY18_RS05295	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
OY18_RS05300	COG2890	protein-(glutamine-N5) methyltransferase activity
OY18_RS05310	COG0688	phosphatidylethanolamine metabolic process
OY18_RS05320	COG0741	lytic transglycosylase activity
OY18_RS05325	COG0617	tRNA 3'-terminal CCA addition
OY18_RS05330	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
OY18_RS05335	COG0109	protoheme IX farnesyltransferase activity
OY18_RS05345	COG0156	8-amino-7-oxononanoate synthase activity
OY18_RS05350	COG2267	carboxylic ester hydrolase activity
OY18_RS05360	COG1846	Transcriptional regulator
OY18_RS05370	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
OY18_RS05385	COG4208	sulfate ABC transporter
OY18_RS05390	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
OY18_RS05415	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
OY18_RS05420	COG0259	pyridoxamine-phosphate oxidase activity
OY18_RS05430	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
OY18_RS05445	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
OY18_RS05475	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
OY18_RS05500	COG2894	cell division
OY18_RS05520	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
OY18_RS05525	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
OY18_RS05530	COG0772	Belongs to the SEDS family
OY18_RS05535	COG0768	penicillin binding
OY18_RS05540	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
OY18_RS05545	COG1792	Involved in formation and maintenance of cell shape
OY18_RS05550	COG1077	Cell shape determining protein MreB Mrl
OY18_RS05605	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
OY18_RS05610	COG1127	ABC transporter
OY18_RS05615	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
OY18_RS05615	COG3218	ABC-type transport auxiliary lipoprotein component
OY18_RS05630	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
OY18_RS05630	COG0644	oxidoreductase
OY18_RS05640	COG2840	Smr protein MutS2
OY18_RS05645	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
OY18_RS05650	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
OY18_RS05655	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
OY18_RS05660	COG0148	phosphopyruvate hydratase activity
OY18_RS05665	COG2877	3-deoxy-8-phosphooctulonate synthase activity
OY18_RS05670	COG0504	CTP synthase activity
OY18_RS05700	COG1253	flavin adenine dinucleotide binding
OY18_RS05705	COG2733	membrane
OY18_RS05725	COG2921	Belongs to the UPF0250 family
OY18_RS05730	COG0321	lipoyl(octanoyl) transferase activity
OY18_RS05735	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
OY18_RS05740	COG5297	Belongs to the glycosyl hydrolase family 6
OY18_RS05760	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
OY18_RS05770	COG0668	transmembrane transport
OY18_RS05775	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
OY18_RS05795	COG2373	Large extracellular alpha-helical protein
OY18_RS05930	COG0582	viral genome integration into host DNA
OY18_RS05945	COG2911	Protein conserved in bacteria
OY18_RS05950	COG0729	surface antigen
OY18_RS05955	COG1956	GAF domain-containing protein
OY18_RS05960	COG1643	Atp-dependent helicase
OY18_RS05985	COG1131	(ABC) transporter
OY18_RS05990	COG0842	Transport permease protein
OY18_RS06030	COG1217	gtp-binding protein TYPA
OY18_RS06035	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
OY18_RS06040	COG0039	L-malate dehydrogenase activity
OY18_RS06045	COG0625	glutathione transferase activity
OY18_RS06050	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
OY18_RS06085	COG1187	pseudouridine synthase activity
OY18_RS06100	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
OY18_RS06105	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
OY18_RS06140	COG0776	regulation of translation
OY18_RS06150	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
OY18_RS06155	COG0740	serine-type endopeptidase activity
OY18_RS06160	COG0544	peptidyl-prolyl cis-trans isomerase activity
OY18_RS06175	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
OY18_RS06185	COG5380	lipid catabolic process
OY18_RS06195	COG0606	chelatase, subunit chli
OY18_RS06200	COG2960	long-chain fatty acid transporting porin activity
OY18_RS06205	COG0203	ribosomal protein L17
OY18_RS06215	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
OY18_RS06220	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
OY18_RS06225	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
OY18_RS06235	COG0200	Binds to the 23S rRNA
OY18_RS06240	COG1841	ribosomal large subunit assembly
OY18_RS06245	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
OY18_RS06255	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
OY18_RS06260	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
OY18_RS06265	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
OY18_RS06270	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
OY18_RS06275	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
OY18_RS06285	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
OY18_RS06290	COG0255	Belongs to the universal ribosomal protein uL29 family
OY18_RS06305	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
OY18_RS06310	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
OY18_RS06315	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
OY18_RS06320	COG0089	rRNA binding
OY18_RS06325	COG0088	Forms part of the polypeptide exit tunnel
OY18_RS06330	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
OY18_RS06345	COG0356	it plays a direct role in the translocation of protons across the membrane
OY18_RS06355	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
OY18_RS06360	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
OY18_RS06365	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
OY18_RS06370	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
OY18_RS06375	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
OY18_RS06380	COG0355	proton-transporting ATP synthase activity, rotational mechanism
OY18_RS06390	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
OY18_RS06405	COG1064	alcohol dehydrogenase
OY18_RS06415	COG0655	NAD(P)H dehydrogenase (quinone) activity
OY18_RS06420	COG0583	DNA-binding transcription factor activity
OY18_RS06425	COG0312	modulator of DNA gyrase
OY18_RS06430	COG3028	Belongs to the UPF0307 family
OY18_RS06435	COG0312	modulator of DNA gyrase
OY18_RS06450	COG0424	maF-like protein
OY18_RS06475	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
OY18_RS06485	COG0019	diaminopimelate decarboxylase activity
OY18_RS06490	COG1024	Enoyl-CoA hydratase
OY18_RS06505	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
OY18_RS06510	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
OY18_RS06515	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
OY18_RS06525	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
OY18_RS06535	COG0505	Belongs to the CarA family
OY18_RS06540	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
OY18_RS06570	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
OY18_RS06600	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
OY18_RS06625	COG1132	(ABC) transporter
OY18_RS06635	COG0811	peptide transport
OY18_RS06645	COG1136	(ABC) transporter
OY18_RS06650	COG4591	ABC-type transport system involved in lipoprotein release permease component
OY18_RS06665	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
OY18_RS06675	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
OY18_RS06680	COG2009	succinate dehydrogenase
OY18_RS06690	COG0354	folic acid binding
OY18_RS06695	COG3842	ATPase activity
OY18_RS06700	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
OY18_RS06705	COG0837	glucose binding
OY18_RS06710	COG0363	glucosamine-6-phosphate deaminase activity
OY18_RS06745	COG0528	UMP kinase activity
OY18_RS06770	COG2067	long-chain fatty acid transport protein
OY18_RS06775	COG0233	cytoplasmic translational termination
OY18_RS06780	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
OY18_RS06785	COG0575	Belongs to the CDS family
OY18_RS06790	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
OY18_RS06795	COG0750	zinc metalloprotease
OY18_RS06805	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
OY18_RS06810	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
OY18_RS06815	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
OY18_RS06820	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
OY18_RS06825	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
OY18_RS06835	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
OY18_RS06885	COG1946	Acyl-CoA thioesterase
OY18_RS06895	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
OY18_RS06905	COG1914	H( )-stimulated, divalent metal cation uptake system
OY18_RS06960	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
OY18_RS06965	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
OY18_RS06970	COG0165	Argininosuccinate lyase
OY18_RS06980	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
OY18_RS06990	COG0137	argininosuccinate synthase activity
OY18_RS06995	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
OY18_RS07010	COG0215	cysteine-tRNA ligase activity
OY18_RS07015	COG2166	iron-sulfur cluster assembly
OY18_RS07035	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
OY18_RS07040	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
OY18_RS07060	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
OY18_RS07070	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
OY18_RS07075	COG0742	ribosomal rna small subunit methyltransferase
OY18_RS07080	COG0326	Molecular chaperone. Has ATPase activity
OY18_RS07085	COG0281	malic enzyme
OY18_RS07085	COG0280	phosphate acetyltransferase
OY18_RS07090	COG1301	dicarboxylic acid transport
OY18_RS07135	COG0556	nucleotide-excision repair
OY18_RS07150	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
OY18_RS07180	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
OY18_RS07185	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
OY18_RS07190	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
OY18_RS07205	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
OY18_RS07205	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
OY18_RS07210	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
OY18_RS07220	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
OY18_RS07225	COG0488	(ABC) transporter
OY18_RS07230	COG0579	oxidoreductase
OY18_RS07235	COG3011	Protein conserved in bacteria
OY18_RS07245	COG1496	oxidoreductase activity
OY18_RS07250	COG0564	pseudouridine synthase activity
OY18_RS07255	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
OY18_RS07275	COG1918	ferrous iron import across plasma membrane
OY18_RS07275	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
OY18_RS07285	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
OY18_RS07295	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
OY18_RS07310	COG0758	DNA mediated transformation
OY18_RS07315	COG2922	Belongs to the Smg family
OY18_RS07320	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
OY18_RS07320	COG1754	DNA topoisomerase type I activity
OY18_RS07325	COG0009	L-threonylcarbamoyladenylate synthase
OY18_RS07360	COG2969	positive regulation of protein catabolic process
OY18_RS07365	COG0625	glutathione transferase activity
OY18_RS07370	COG2857	Cytochrome c1
OY18_RS07375	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
OY18_RS07380	COG0723	plastoquinol--plastocyanin reductase activity
OY18_RS07390	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
OY18_RS07395	COG1702	phosphate starvation-inducible protein PhoH
OY18_RS07400	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
OY18_RS07410	COG4535	Mg2 and Co2 transporter CorC
OY18_RS07490	COG2264	protein methyltransferase activity
OY18_RS07500	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
OY18_RS07505	COG0277	FAD linked oxidase domain protein
OY18_RS07510	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
OY18_RS07515	COG0531	amino acid
OY18_RS07520	COG0531	amino acid
OY18_RS07525	COG0235	Class ii aldolase
OY18_RS07530	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
OY18_RS07535	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
OY18_RS07540	COG0140	phosphoribosyl-ATP diphosphatase activity
OY18_RS07540	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
OY18_RS07550	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
OY18_RS07560	COG0131	Imidazoleglycerol-phosphate dehydratase
OY18_RS07560	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
OY18_RS07570	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
OY18_RS07575	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
OY18_RS07585	COG0124	histidyl-tRNA synthetase
OY18_RS07595	COG0083	homoserine kinase activity
OY18_RS07600	COG0460	homoserine dehydrogenase
OY18_RS07600	COG0527	aspartate kinase activity
OY18_RS07605	COG0540	Belongs to the ATCase OTCase family
OY18_RS07615	COG1678	Uncharacterized ACR, COG1678
OY18_RS07625	COG1686	Belongs to the peptidase S11 family
OY18_RS07635	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
OY18_RS07650	COG4953	penicillin-binding protein 1C
OY18_RS07680	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
OY18_RS07685	COG0481	GTPase activity
OY18_RS07700	COG0571	ribonuclease III activity
OY18_RS07705	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
OY18_RS07710	COG1381	Involved in DNA repair and RecF pathway recombination
OY18_RS07715	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
OY18_RS07720	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
OY18_RS07735	COG1971	Probably functions as a manganese efflux pump
OY18_RS07745	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
OY18_RS07755	COG1297	OPT oligopeptide transporter protein
OY18_RS07775	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
OY18_RS07785	COG0676	glucose-6-phosphate 1-epimerase activity
OY18_RS07795	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
OY18_RS07800	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
OY18_RS07810	COG0318	PFAM AMP-dependent synthetase and ligase
OY18_RS07820	COG0463	Glycosyl transferase, family 2
OY18_RS07830	COG1475	DNA binding
OY18_RS07835	COG1192	Involved in chromosome partitioning
OY18_RS07845	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
OY18_RS07905	COG2226	methyltransferase
OY18_RS07910	COG0308	aminopeptidase N
OY18_RS07930	COG2912	Transglutaminase-like superfamily
OY18_RS07945	COG0175	sulfate reduction
OY18_RS07950	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
OY18_RS07960	COG0175	sulfate reduction
OY18_RS07965	COG0529	Catalyzes the synthesis of activated sulfate
OY18_RS07965	COG2895	sulfate adenylyltransferase (ATP) activity
OY18_RS07970	COG1758	RNA polymerase activity
OY18_RS07975	COG0194	GDP metabolic process
OY18_RS07980	COG1561	YicC-like family, N-terminal region
OY18_RS07985	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
OY18_RS07990	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
OY18_RS07995	COG0635	Involved in the biosynthesis of porphyrin-containing compound
OY18_RS08010	COG0596	Alpha beta hydrolase
OY18_RS08015	COG2890	protein-(glutamine-N5) methyltransferase activity
OY18_RS08030	COG5295	Hep Hag repeat protein
OY18_RS08035	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
OY18_RS08040	COG1459	type II secretion system
OY18_RS08045	COG2165	general secretion pathway protein
OY18_RS08050	COG4970	Tfp pilus assembly protein FimT
OY18_RS08055	COG2165	general secretion pathway protein
OY18_RS08060	COG4795	General secretion pathway protein
OY18_RS08070	COG3166	PFAM Fimbrial assembly family protein
OY18_RS08085	COG1450	Type ii and iii secretion system protein
OY18_RS08105	COG3634	alkyl hydroperoxide reductase activity
OY18_RS08110	COG0583	DNA-binding transcription factor activity
OY18_RS08130	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
OY18_RS08135	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
OY18_RS08140	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
OY18_RS08160	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
OY18_RS08185	COG0567	Dehydrogenase, E1 component
OY18_RS08190	COG2850	peptidyl-arginine hydroxylation
OY18_RS08210	COG0114	fumarate hydratase activity
OY18_RS08250	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
OY18_RS08270	COG3772	lysozyme
OY18_RS08295	COG5410	chromosome segregation
OY18_RS08300	COG3567	Phage-associated protein, HI1409 family
OY18_RS08315	COG2369	cell adhesion
OY18_RS08410	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
OY18_RS08415	COG3657	addiction module killer protein
OY18_RS08435	COG1131	(ABC) transporter
OY18_RS08440	COG0386	Belongs to the glutathione peroxidase family
OY18_RS08455	COG2900	Belongs to the SlyX family
OY18_RS08470	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
OY18_RS08480	COG2027	D-alanyl-D-alanine carboxypeptidase
OY18_RS08490	COG2226	methyltransferase
OY18_RS08505	COG2943	transferase activity, transferring hexosyl groups
OY18_RS08515	COG3275	phosphorelay sensor kinase activity
OY18_RS08525	COG0181	hydroxymethylbilane synthase activity
OY18_RS08570	COG0463	Glycosyl transferase, family 2
OY18_RS08580	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
OY18_RS08595	COG0392	lysyltransferase activity
OY18_RS08595	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
OY18_RS08600	COG0251	oxidation-reduction process
OY18_RS08615	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
OY18_RS08620	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
OY18_RS08625	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
OY18_RS08630	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
OY18_RS08640	COG0582	viral genome integration into host DNA
OY18_RS08650	COG1396	sequence-specific DNA binding
OY18_RS08660	COG0583	DNA-binding transcription factor activity
OY18_RS08665	COG0667	Aldo Keto reductase
OY18_RS08670	COG0667	Aldo Keto reductase
OY18_RS08675	COG1942	4-Oxalocrotonate Tautomerase
OY18_RS08695	COG0667	Aldo Keto reductase
OY18_RS08700	COG0583	DNA-binding transcription factor activity
OY18_RS08705	COG1902	pentaerythritol trinitrate reductase activity
OY18_RS08715	COG1064	alcohol dehydrogenase
OY18_RS08745	COG2133	pyrroloquinoline quinone binding
OY18_RS08750	COG1028	Short-chain dehydrogenase reductase Sdr
OY18_RS08755	COG3386	PFAM SMP-30 Gluconolaconase
OY18_RS08765	COG4221	oxidoreductase activity
OY18_RS08775	COG1064	alcohol dehydrogenase
OY18_RS08950	COG0270	DNA (cytosine-5-)-methyltransferase activity
OY18_RS08960	COG0629	single-stranded DNA binding
OY18_RS09050	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
OY18_RS09055	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
OY18_RS09055	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
OY18_RS09080	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
OY18_RS09085	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
OY18_RS09090	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
OY18_RS09100	COG0338	D12 class N6 adenine-specific DNA methyltransferase
OY18_RS09120	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
OY18_RS09125	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
OY18_RS09130	COG0537	adenosine 5'-monophosphoramidase activity
OY18_RS09150	COG0714	Associated with various cellular activities
OY18_RS09160	COG1399	metal-binding, possibly nucleic acid-binding protein
OY18_RS09165	COG0333	Belongs to the bacterial ribosomal protein bL32 family
OY18_RS09175	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
OY18_RS09195	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
OY18_RS09205	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
OY18_RS09210	COG1764	response to oxidative stress
OY18_RS09215	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
OY18_RS09240	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
OY18_RS09250	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
OY18_RS09270	COG2353	YceI-like domain
OY18_RS09275	COG1968	undecaprenyl-diphosphatase activity
OY18_RS09280	COG0174	glutamine synthetase
OY18_RS09285	COG0347	Belongs to the P(II) protein family
OY18_RS09290	COG0004	ammonium transporteR
OY18_RS09305	COG2204	response regulator
OY18_RS09355	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
OY18_RS09360	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
OY18_RS09380	COG0629	single-stranded DNA binding
OY18_RS09405	COG4969	Belongs to the N-Me-Phe pilin family
OY18_RS09615	COG0629	single-stranded DNA binding
OY18_RS09635	COG4969	Belongs to the N-Me-Phe pilin family
OY18_RS09765	COG0740	serine-type endopeptidase activity
OY18_RS09780	COG3772	lysozyme
OY18_RS09825	COG5449	Phage conserved hypothetical protein BR0599
OY18_RS09905	COG0445	tRNA wobble uridine modification
OY18_RS09945	COG1469	GTP cyclohydrolase I activity
OY18_RS09955	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
OY18_RS09975	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
OY18_RS10010	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
OY18_RS10015	COG1028	Short-chain dehydrogenase reductase Sdr
OY18_RS10020	COG3077	Addiction module antitoxin, RelB DinJ family
OY18_RS10025	COG3041	Addiction module toxin RelE StbE family
OY18_RS10055	COG4691	Plasmid stability protein
OY18_RS10060	COG3609	addiction module antidote protein, CC2985 family
OY18_RS10300	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
OY18_RS10325	COG2925	Exonuclease
OY18_RS10340	COG0025	NhaP-type Na H and K H
OY18_RS10350	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
OY18_RS10360	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
OY18_RS10380	COG3079	Belongs to the UPF0149 family
OY18_RS10385	COG0006	proline dipeptidase activity
OY18_RS10430	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
OY18_RS10435	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
OY18_RS10470	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
OY18_RS10475	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
OY18_RS10485	COG0557	exoribonuclease II activity
OY18_RS10495	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
OY18_RS10500	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
OY18_RS10505	COG0302	gtp cyclohydrolase
OY18_RS10520	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
OY18_RS10525	COG1289	transmembrane transporter activity
OY18_RS10535	COG0151	Belongs to the GarS family
OY18_RS10540	COG0138	bifunctional purine biosynthesis protein purh
OY18_RS10555	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
OY18_RS10565	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
OY18_RS10585	COG0596	Alpha beta hydrolase
OY18_RS10590	COG0727	PFAM Uncharacterised protein family (UPF0153)
OY18_RS10605	COG0752	glycyl-tRNA synthetase alpha subunit
OY18_RS10610	COG0751	glycine-tRNA ligase activity
OY18_RS10625	COG0189	ligase activity
OY18_RS10640	COG0840	transmembrane signaling receptor activity
OY18_RS10645	COG0643	Histidine kinase
OY18_RS10645	COG0784	Response regulator, receiver
OY18_RS10645	COG2198	Histidine kinase
OY18_RS10675	COG0285	dihydrofolate synthase activity
OY18_RS10685	COG0339	signal peptide processing
OY18_RS10710	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
OY18_RS10715	COG1301	dicarboxylic acid transport
OY18_RS10720	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
OY18_RS10725	COG0357	Ribosomal RNA small subunit methyltransferase G
OY18_RS10730	COG2091	lysine biosynthetic process via aminoadipic acid
OY18_RS10795	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
OY18_RS10800	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
OY18_RS10810	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
OY18_RS10815	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
OY18_RS10840	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
OY18_RS10840	COG0512	Glutamine amidotransferase of anthranilate synthase
OY18_RS10850	COG0084	hydrolase, TatD family'
OY18_RS10865	COG0552	protein localization to endoplasmic reticulum
OY18_RS10875	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
OY18_RS10885	COG0217	transcriptional regulatory protein
OY18_RS10890	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
OY18_RS10895	COG0632	four-way junction helicase activity
OY18_RS10900	COG3158	transport of potassium into the cell
OY18_RS10905	COG2255	four-way junction helicase activity
OY18_RS10910	COG0824	Thioesterase
OY18_RS10930	COG0823	Involved in the tonB-independent uptake of proteins
OY18_RS10935	COG2885	chlorophyll binding
OY18_RS10945	COG0602	queuosine metabolic process
OY18_RS10950	COG0588	phosphoglycerate mutase activity
OY18_RS10955	COG1515	deoxyribonuclease V activity
OY18_RS10965	COG0386	Belongs to the glutathione peroxidase family
OY18_RS10975	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
OY18_RS10985	COG0406	alpha-ribazole phosphatase activity
OY18_RS11115	COG5449	Phage conserved hypothetical protein BR0599
OY18_RS11160	COG3772	lysozyme
OY18_RS11175	COG0740	serine-type endopeptidase activity
OY18_RS11260	COG0488	(ABC) transporter
OY18_RS11270	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
OY18_RS11285	COG4651	solute:proton antiporter activity
OY18_RS11285	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
OY18_RS11290	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
OY18_RS11295	COG0573	inorganic phosphate transmembrane transporter activity
OY18_RS11300	COG0581	inorganic phosphate transmembrane transporter activity
OY18_RS11305	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
OY18_RS11310	COG0704	Plays a role in the regulation of phosphate uptake
OY18_RS11315	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
OY18_RS11320	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
OY18_RS11325	COG2967	ApaG domain
OY18_RS11330	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
OY18_RS11345	COG3642	lipopolysaccharide core region biosynthetic process
OY18_RS11350	COG0859	PFAM glycosyl transferase family 9
OY18_RS11365	COG0631	protein serine/threonine phosphatase activity
OY18_RS11370	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
OY18_RS11375	COG0328	RNA-DNA hybrid ribonuclease activity
OY18_RS11385	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
OY18_RS11400	COG2183	response to ionizing radiation
OY18_RS11415	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
OY18_RS11425	COG3118	belongs to the thioredoxin family
OY18_RS11435	COG0495	leucyl-tRNA aminoacylation
OY18_RS11450	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
OY18_RS11480	COG2951	lytic endotransglycosylase activity
OY18_RS11485	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
OY18_RS11560	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
OY18_RS11570	COG1199	ATP-dependent helicase activity
OY18_RS11580	COG0288	reversible hydration of carbon dioxide
OY18_RS11605	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
OY18_RS11610	COG2011	ABC-type metal ion transport system permease component
OY18_RS11615	COG1464	Belongs to the NlpA lipoprotein family
OY18_RS11630	COG0508	dehydrogenase complex catalyzes the overall conversion of
OY18_RS11650	COG0626	cystathionine gamma-synthase activity
OY18_RS11655	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
OY18_RS11660	COG0739	heme binding
OY18_RS11675	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
OY18_RS11680	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
OY18_RS11685	COG1238	metal cluster binding
OY18_RS11700	COG5002	protein histidine kinase activity
OY18_RS11710	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
OY18_RS11715	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
OY18_RS11720	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
OY18_RS11725	COG1388	LysM domain
OY18_RS11725	COG3858	chitin binding
OY18_RS11730	COG3525	Glycosyl hydrolase, family 20, catalytic domain
OY18_RS11740	COG1472	Belongs to the glycosyl hydrolase 3 family
OY18_RS11755	COG3537	Alpha-1,2-mannosidase
OY18_RS11765	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
OY18_RS11770	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
OY18_RS11775	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
OY18_RS11785	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
OY18_RS11790	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
OY18_RS11795	COG0583	DNA-binding transcription factor activity
OY18_RS11825	COG3588	fructose-bisphosphate aldolase
OY18_RS11835	COG0469	pyruvate kinase activity
OY18_RS11845	COG0126	phosphoglycerate kinase activity
OY18_RS11850	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
OY18_RS11855	COG0735	belongs to the Fur family
OY18_RS11865	COG5297	Belongs to the glycosyl hydrolase family 6
OY18_RS11865	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
OY18_RS11875	COG0612	Peptidase, M16
OY18_RS11890	COG4305	rare lipoprotein A
OY18_RS11895	COG0653	protein targeting
OY18_RS11900	COG0739	heme binding
OY18_RS11910	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
OY18_RS11920	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
OY18_RS11930	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
OY18_RS11935	COG1181	Belongs to the D-alanine--D-alanine ligase family
OY18_RS11940	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
OY18_RS11945	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
OY18_RS11955	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
OY18_RS11960	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
OY18_RS11965	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
OY18_RS11975	COG3116	cell division
OY18_RS11980	COG0275	rRNA processing
OY18_RS11985	COG2001	Belongs to the MraZ family
OY18_RS12000	COG0471	metal ion transport
OY18_RS12000	COG3273	potassium ion transport
OY18_RS12005	COG0220	tRNA (guanine-N7-)-methyltransferase activity
OY18_RS12010	COG2022	thiamine diphosphate biosynthetic process
OY18_RS12040	COG2755	lipolytic protein G-D-S-L family
OY18_RS12040	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
OY18_RS12070	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
OY18_RS12095	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
OY18_RS12095	COG3453	Protein conserved in bacteria
OY18_RS12100	COG0640	Transcriptional regulator
OY18_RS12105	COG2391	methyltransferase activity
OY18_RS12110	COG2391	methyltransferase activity
OY18_RS12115	COG0730	response to heat
OY18_RS12120	COG0717	Belongs to the dCTP deaminase family
OY18_RS12130	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
OY18_RS12135	COG0860	N-Acetylmuramoyl-L-alanine amidase
OY18_RS12140	COG0802	atpase or kinase
OY18_RS12145	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
OY18_RS12145	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
OY18_RS12155	COG1570	exodeoxyribonuclease VII activity
OY18_RS12200	COG0776	regulation of translation
OY18_RS12205	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
OY18_RS12205	COG0072	phenylalanine-tRNA ligase activity
OY18_RS12210	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
OY18_RS12215	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
OY18_RS12225	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
OY18_RS12230	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
OY18_RS12300	COG3093	addiction module antidote protein HigA
OY18_RS12370	COG3772	lysozyme
OY18_RS12490	COG3617	BRO family, N-terminal domain
OY18_RS12520	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
OY18_RS12540	COG0745	RESPONSE REGULATOR receiver
OY18_RS12545	COG0642	Histidine kinase
OY18_RS12550	COG0237	dephospho-CoA kinase activity
OY18_RS12555	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
OY18_RS12615	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
OY18_RS12625	COG2831	hemolysin activation secretion protein
OY18_RS12640	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
OY18_RS12650	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
OY18_RS12660	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
OY18_RS12665	COG3115	cell septum assembly
OY18_RS12675	COG0359	binds to the 23S rRNA
OY18_RS12680	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
OY18_RS12690	COG0316	Belongs to the HesB IscA family
OY18_RS12695	COG0017	Asparaginyl-tRNA synthetase
OY18_RS12725	COG0167	dihydroorotate dehydrogenase activity
OY18_RS12730	COG0812	UDP-N-acetylmuramate dehydrogenase activity
OY18_RS12735	COG0697	spore germination
OY18_RS12745	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
OY18_RS12760	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
OY18_RS12765	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
OY18_RS12780	COG1132	(ABC) transporter
OY18_RS12790	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
OY18_RS12795	COG1538	Outer membrane efflux protein
OY18_RS12800	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
OY18_RS12815	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
OY18_RS12830	COG4783	chaperone-mediated protein folding
OY18_RS12840	COG0473	3-isopropylmalate dehydrogenase activity
OY18_RS12850	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
OY18_RS12860	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
OY18_RS12870	COG0316	Belongs to the HesB IscA family
OY18_RS12870	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
OY18_RS12875	COG2154	pterin-4-alpha-carbinolamine dehydratase
OY18_RS12885	COG0564	pseudouridine synthase activity
OY18_RS12890	COG1530	ribonuclease E activity
OY18_RS12895	COG2197	response regulator
OY18_RS12900	COG1054	Belongs to the UPF0176 family
OY18_RS12915	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
OY18_RS12930	COG0488	(ABC) transporter
OY18_RS12940	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
OY18_RS12945	COG1278	Cold shock
OY18_RS12955	COG0501	Belongs to the peptidase M48B family
OY18_RS12965	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
OY18_RS12970	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
OY18_RS12975	COG0049	tRNA binding
OY18_RS12985	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
OY18_RS12990	COG0085	RNA polymerase activity
OY18_RS12995	COG0222	ribosome binding
OY18_RS13000	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
OY18_RS13005	COG0081	regulation of translation
OY18_RS13010	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
OY18_RS13015	COG0250	Participates in transcription elongation, termination and antitermination
OY18_RS13020	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
OY18_RS13030	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
OY18_RS13050	COG0012	GTP binding
OY18_RS13055	COG0193	aminoacyl-tRNA hydrolase activity
OY18_RS13065	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
OY18_RS13075	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
OY18_RS13080	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
OY18_RS13090	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
OY18_RS13095	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
OY18_RS13105	COG0116	Belongs to the methyltransferase superfamily
OY18_RS13105	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
OY18_RS13155	COG2095	MarC family integral membrane protein
OY18_RS13165	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
OY18_RS13180	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
OY18_RS13195	COG2132	Multicopper oxidase
OY18_RS13205	COG0210	DNA helicase
OY18_RS13210	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
OY18_RS13215	COG0616	signal peptide processing
OY18_RS13220	COG0534	Mate efflux family protein
OY18_RS13240	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
OY18_RS13250	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
OY18_RS13255	COG2201	protein-glutamate methylesterase activity
OY18_RS13260	COG2177	Part of the ABC transporter FtsEX involved in
OY18_RS13265	COG2884	Cell division ATP-binding protein ftsE
OY18_RS13270	COG0513	Belongs to the DEAD box helicase family
OY18_RS13275	COG3118	belongs to the thioredoxin family
OY18_RS13280	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
OY18_RS13295	COG0793	Belongs to the peptidase S41A family
OY18_RS13300	COG4942	peptidase
OY18_RS13315	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
OY18_RS13320	COG0493	'glutamate synthase
OY18_RS13325	COG0069	glutamate synthase activity
OY18_RS13325	COG0067	glutamate synthase
OY18_RS13325	COG0070	glutamate synthase
OY18_RS13360	COG1028	Short-chain dehydrogenase reductase Sdr
OY18_RS13385	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
OY18_RS13410	COG0732	type I restriction modification DNA specificity domain
OY18_RS13425	COG1280	lysine exporter protein (LysE YggA)
OY18_RS13470	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
OY18_RS13485	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
OY18_RS13605	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
OY18_RS13610	COG3657	addiction module killer protein
OY18_RS13670	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
OY18_RS13680	COG0706	membrane insertase activity
OY18_RS13685	COG0594	ribonuclease P activity
OY18_RS13795	COG3505	Type IV secretory pathway VirD4
OY18_RS13820	COG0675	Transposase, IS605 OrfB family
OY18_RS13890	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
OY18_RS13905	COG3451	type IV secretory pathway VirB4
OY18_RS13930	COG3736	Type IV secretory pathway, component VirB8
OY18_RS13940	COG2948	multi-organism process
OY18_RS13975	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
OY18_RS14105	COG3657	addiction module killer protein
OY18_RS14180	COG1475	DNA binding
OY18_RS14190	COG0629	single-stranded DNA binding