locus-tag	class	description
BC375_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BC375_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BC375_RS00025	COG0187	DNA topoisomerase II activity
BC375_RS00035	COG0501	Belongs to the peptidase M48B family
BC375_RS00075	COG0408	coproporphyrinogen oxidase activity
BC375_RS00105	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BC375_RS00120	COG4969	Belongs to the N-Me-Phe pilin family
BC375_RS00150	COG0284	orotidine-5'-phosphate decarboxylase activity
BC375_RS00185	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
BC375_RS00195	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BC375_RS00205	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BC375_RS00210	COG0511	ligase activity, forming carbon-carbon bonds
BC375_RS00215	COG0439	Biotin carboxylase
BC375_RS00230	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
BC375_RS00230	COG1017	nitric oxide dioxygenase activity
BC375_RS00245	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
BC375_RS00255	COG1040	competence protein
BC375_RS00260	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
BC375_RS00265	COG1752	Esterase of the alpha-beta hydrolase superfamily
BC375_RS00275	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
BC375_RS00310	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BC375_RS00320	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BC375_RS00350	COG3121	Chaperone
BC375_RS00355	COG3539	Fimbrial protein
BC375_RS00360	COG1546	Belongs to the CinA family
BC375_RS00365	COG0477	Major facilitator Superfamily
BC375_RS00370	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BC375_RS00375	COG1923	regulation of RNA biosynthetic process
BC375_RS00380	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BC375_RS00385	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BC375_RS00395	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BC375_RS00405	COG1534	Rna-binding protein
BC375_RS00435	COG1560	Kdo2-lipid A biosynthetic process
BC375_RS00440	COG1519	Transferase
BC375_RS00450	COG0228	four-way junction DNA binding
BC375_RS00455	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BC375_RS00460	COG0336	Belongs to the RNA methyltransferase TrmD family
BC375_RS00465	COG0335	large ribosomal subunit rRNA binding
BC375_RS00485	COG2171	N-acyltransferase activity
BC375_RS00490	COG1393	Belongs to the ArsC family
BC375_RS00495	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BC375_RS00500	COG0367	asparagine synthase
BC375_RS00510	COG2070	2-Nitropropane dioxygenase
BC375_RS00520	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BC375_RS00525	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BC375_RS00540	COG0339	signal peptide processing
BC375_RS00565	COG0525	valine-tRNA ligase activity
BC375_RS00605	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BC375_RS00615	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
BC375_RS00625	COG4221	oxidoreductase activity
BC375_RS00645	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BC375_RS00655	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BC375_RS00665	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
BC375_RS00710	COG2223	nitrite transmembrane transporter activity
BC375_RS00715	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
BC375_RS00720	COG0739	heme binding
BC375_RS00725	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BC375_RS00755	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BC375_RS00770	COG1028	Short-chain dehydrogenase reductase Sdr
BC375_RS00775	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
BC375_RS00780	COG1272	protein, Hemolysin III
BC375_RS00785	COG0463	Glycosyl transferase, family 2
BC375_RS00790	COG0084	hydrolase, TatD family'
BC375_RS00805	COG0509	glycine decarboxylation via glycine cleavage system
BC375_RS00810	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BC375_RS00825	COG3956	TIGRFAM MazG family protein
BC375_RS00830	COG1218	3'(2'),5'-bisphosphate nucleotidase
BC375_RS00835	COG0494	nUDIX hydrolase
BC375_RS00845	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BC375_RS00860	COG0513	Belongs to the DEAD box helicase family
BC375_RS00865	COG0720	synthase
BC375_RS00895	COG1981	membrane
BC375_RS00900	COG0825	malonyl-CoA metabolic process
BC375_RS00905	COG0587	DNA-directed DNA polymerase activity
BC375_RS00935	COG0512	Glutamine amidotransferase of anthranilate synthase
BC375_RS00940	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BC375_RS00945	COG0134	indole-3-glycerol-phosphate synthase activity
BC375_RS00970	COG0006	proline dipeptidase activity
BC375_RS00985	COG0343	queuine tRNA-ribosyltransferase activity
BC375_RS00990	COG1862	Preprotein translocase
BC375_RS00995	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BC375_RS01010	COG0617	tRNA 3'-terminal CCA addition
BC375_RS01020	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
BC375_RS01025	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
BC375_RS01030	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
BC375_RS01035	COG0166	Belongs to the GPI family
BC375_RS01050	COG0779	Required for maturation of 30S ribosomal subunits
BC375_RS01055	COG0195	Participates in both transcription termination and antitermination
BC375_RS01060	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BC375_RS01065	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BC375_RS01080	COG1185	polyribonucleotide nucleotidyltransferase activity
BC375_RS01085	COG1733	regulation of RNA biosynthetic process
BC375_RS01090	COG0702	epimerase
BC375_RS01150	COG2086	electron transfer activity
BC375_RS01180	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BC375_RS01220	COG0477	Major facilitator Superfamily
BC375_RS01235	COG0563	adenylate kinase activity
BC375_RS01240	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BC375_RS01245	COG0671	phosphoesterase, PA-phosphatase related
BC375_RS01255	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BC375_RS01260	COG0628	permease
BC375_RS01280	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BC375_RS01285	COG1090	epimerase
BC375_RS01290	COG0318	PFAM AMP-dependent synthetase and ligase
BC375_RS01325	COG1049	propionate catabolic process, 2-methylcitrate cycle
BC375_RS01400	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BC375_RS01410	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BC375_RS01420	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
BC375_RS01430	COG1034	ATP synthesis coupled electron transport
BC375_RS01450	COG0713	ATP synthesis coupled electron transport
BC375_RS01465	COG1007	ATP synthesis coupled electron transport
BC375_RS01470	COG1028	Short-chain dehydrogenase reductase Sdr
BC375_RS01475	COG2851	Citrate transporter
BC375_RS01490	COG0642	Histidine kinase
BC375_RS01540	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
BC375_RS01545	COG4206	TonB-dependent receptor
BC375_RS01550	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
BC375_RS01570	COG0277	FAD linked oxidase domain protein
BC375_RS01575	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BC375_RS01590	COG2124	cytochrome p450
BC375_RS01600	COG0305	Participates in initiation and elongation during chromosome replication
BC375_RS01615	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BC375_RS01620	COG0667	Aldo Keto reductase
BC375_RS01625	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
BC375_RS01660	COG2194	sulfuric ester hydrolase activity
BC375_RS01670	COG0352	thiamine-phosphate diphosphorylase activity
BC375_RS01680	COG0542	response to heat
BC375_RS01725	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BC375_RS01740	COG0494	nUDIX hydrolase
BC375_RS01750	COG2193	ferroxidase activity
BC375_RS01800	COG0861	Integral membrane protein TerC family
BC375_RS01805	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BC375_RS01810	COG0531	amino acid
BC375_RS01820	COG1116	anion transmembrane transporter activity
BC375_RS01830	COG1322	Protein conserved in bacteria
BC375_RS01840	COG2853	Lipoprotein
BC375_RS01855	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BC375_RS01860	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BC375_RS01865	COG1127	ABC transporter
BC375_RS01900	COG0358	DNA primase activity
BC375_RS01910	COG1610	YqeY-like protein
BC375_RS01920	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BC375_RS01925	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BC375_RS01930	COG0668	transmembrane transport
BC375_RS01950	COG1183	phosphatidylcholine synthase activity
BC375_RS01960	COG0442	prolyl-tRNA aminoacylation
BC375_RS01980	COG0604	alcohol dehydrogenase
BC375_RS01985	COG0330	HflC and HflK could
BC375_RS01990	COG0330	HflC and HflK could
BC375_RS02000	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
BC375_RS02005	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BC375_RS02010	COG0105	UTP biosynthetic process
BC375_RS02015	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BC375_RS02035	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BC375_RS02040	COG1160	GTP binding
BC375_RS02045	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BC375_RS02060	COG4943	cyclic-guanylate-specific phosphodiesterase activity
BC375_RS02065	COG1611	Belongs to the LOG family
BC375_RS02070	COG4968	Prepilin-type N-terminal cleavage methylation domain
BC375_RS02165	COG2878	Part of a membrane complex involved in electron transport
BC375_RS02170	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BC375_RS02170	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BC375_RS02180	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
BC375_RS02185	COG3107	peptidoglycan biosynthetic process
BC375_RS02195	COG1162	GTPase activity
BC375_RS02200	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
BC375_RS02220	COG0519	Catalyzes the synthesis of GMP from XMP
BC375_RS02220	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BC375_RS02250	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
BC375_RS02265	COG0037	tRNA processing
BC375_RS02275	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BC375_RS02295	COG3590	peptidase
BC375_RS02320	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BC375_RS02330	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BC375_RS02340	COG0628	permease
BC375_RS02350	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
BC375_RS02355	COG3178	'Phosphotransferase
BC375_RS02360	COG1555	photosystem II stabilization
BC375_RS02365	COG1477	protein flavinylation
BC375_RS02385	COG3128	pkhd-type hydroxylase
BC375_RS02390	COG4774	siderophore transport
BC375_RS02410	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BC375_RS02425	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
BC375_RS02430	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BC375_RS02435	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BC375_RS02460	COG0459	protein refolding
BC375_RS02470	COG1324	tolerance protein
BC375_RS02480	COG0352	thiamine-phosphate diphosphorylase activity
BC375_RS02480	COG0351	phosphomethylpyrimidine kinase
BC375_RS02490	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BC375_RS02535	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BC375_RS02550	COG2311	Membrane
BC375_RS02560	COG0791	NLP P60 protein
BC375_RS02565	COG0791	NLP P60 protein
BC375_RS02575	COG1301	dicarboxylic acid transport
BC375_RS02585	COG0037	tRNA processing
BC375_RS02590	COG1722	exodeoxyribonuclease VII activity
BC375_RS02595	COG0142	geranyltranstransferase activity
BC375_RS02635	COG1028	Short-chain dehydrogenase reductase Sdr
BC375_RS02650	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BC375_RS02655	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BC375_RS02680	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
BC375_RS02685	COG0483	inositol monophosphate 1-phosphatase activity
BC375_RS02695	COG1509	lysine 2,3-aminomutase activity
BC375_RS02705	COG0402	S-adenosylhomocysteine deaminase activity
BC375_RS02715	COG0546	phosphoglycolate phosphatase activity
BC375_RS02730	COG5434	Belongs to the glycosyl hydrolase 28 family
BC375_RS02735	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BC375_RS02755	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BC375_RS02760	COG1138	Cytochrome C-type biogenesis protein
BC375_RS02765	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
BC375_RS02785	COG4133	protoheme IX ABC transporter activity
BC375_RS02790	COG0436	Aminotransferase
BC375_RS02805	COG1187	pseudouridine synthase activity
BC375_RS02810	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BC375_RS02815	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
BC375_RS02840	COG1175	transmembrane transport
BC375_RS02845	COG0395	ABC-type sugar transport system, permease component
BC375_RS02880	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BC375_RS02890	COG0776	regulation of translation
BC375_RS02900	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
BC375_RS02915	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BC375_RS02920	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BC375_RS02930	COG0519	Catalyzes the synthesis of GMP from XMP
BC375_RS02930	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BC375_RS02950	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BC375_RS02955	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BC375_RS02960	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BC375_RS02965	COG0268	Binds directly to 16S ribosomal RNA
BC375_RS02970	COG0728	peptidoglycan biosynthetic process
BC375_RS02975	COG0196	riboflavin kinase activity
BC375_RS02980	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BC375_RS03105	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
BC375_RS03120	COG3757	hydrolase, family 25
BC375_RS03120	COG3409	Peptidoglycan-binding domain 1 protein
BC375_RS03130	COG1064	alcohol dehydrogenase
BC375_RS03145	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BC375_RS03150	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BC375_RS03155	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BC375_RS03155	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BC375_RS03175	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BC375_RS03180	COG0066	3-isopropylmalate dehydratase activity
BC375_RS03185	COG0473	3-isopropylmalate dehydrogenase activity
BC375_RS03215	COG0438	transferase activity, transferring glycosyl groups
BC375_RS03230	COG0438	transferase activity, transferring glycosyl groups
BC375_RS03235	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
BC375_RS03240	COG0745	RESPONSE REGULATOR receiver
BC375_RS03250	COG2954	triphosphatase activity
BC375_RS03260	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
BC375_RS03270	COG1278	Cold shock
BC375_RS03290	COG2914	Belongs to the UPF0125 (RnfH) family
BC375_RS03295	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BC375_RS03305	COG0497	DNA recombination
BC375_RS03315	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BC375_RS03320	COG0443	Heat shock 70 kDa protein
BC375_RS03325	COG0484	heat shock protein binding
BC375_RS03330	COG1605	Chorismate mutase
BC375_RS03330	COG0287	Prephenate dehydrogenase
BC375_RS03350	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
BC375_RS03375	COG4555	ABC transporter
BC375_RS03380	COG1668	transmembrane transport
BC375_RS03390	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
BC375_RS03395	COG1605	Chorismate mutase
BC375_RS03395	COG0077	Prephenate dehydratase
BC375_RS03400	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BC375_RS03455	COG0322	excinuclease ABC activity
BC375_RS03460	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BC375_RS03495	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BC375_RS03500	COG0489	protein tyrosine kinase activity
BC375_RS03505	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
BC375_RS03510	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BC375_RS03565	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BC375_RS03575	COG1192	Involved in chromosome partitioning
BC375_RS03580	COG1475	DNA binding
BC375_RS03590	COG0463	Glycosyl transferase, family 2
BC375_RS03600	COG0318	PFAM AMP-dependent synthetase and ligase
BC375_RS03610	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BC375_RS03625	COG0676	glucose-6-phosphate 1-epimerase activity
BC375_RS03635	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
BC375_RS03640	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BC375_RS03655	COG1297	OPT oligopeptide transporter protein
BC375_RS03665	COG0823	Involved in the tonB-independent uptake of proteins
BC375_RS03665	COG1506	peptidase
BC375_RS03670	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BC375_RS03685	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BC375_RS03695	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BC375_RS03700	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BC375_RS03705	COG1381	Involved in DNA repair and RecF pathway recombination
BC375_RS03710	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
BC375_RS03715	COG0571	ribonuclease III activity
BC375_RS03735	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BC375_RS03760	COG4953	penicillin-binding protein 1C
BC375_RS03775	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
BC375_RS03785	COG1686	Belongs to the peptidase S11 family
BC375_RS03795	COG1678	Uncharacterized ACR, COG1678
BC375_RS03805	COG0540	Belongs to the ATCase OTCase family
BC375_RS03810	COG0460	homoserine dehydrogenase
BC375_RS03810	COG0527	aspartate kinase activity
BC375_RS03815	COG0083	homoserine kinase activity
BC375_RS03825	COG0124	histidyl-tRNA synthetase
BC375_RS03835	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
BC375_RS03840	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
BC375_RS03850	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
BC375_RS03850	COG0131	Imidazoleglycerol-phosphate dehydratase
BC375_RS03860	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
BC375_RS03875	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
BC375_RS03880	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
BC375_RS03885	COG0235	Class ii aldolase
BC375_RS03890	COG0531	amino acid
BC375_RS03895	COG0531	amino acid
BC375_RS03900	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BC375_RS03905	COG0277	FAD linked oxidase domain protein
BC375_RS03910	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BC375_RS04005	COG2951	lytic endotransglycosylase activity
BC375_RS04035	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BC375_RS04050	COG0495	leucyl-tRNA aminoacylation
BC375_RS04060	COG3118	belongs to the thioredoxin family
BC375_RS04070	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
BC375_RS04085	COG2183	response to ionizing radiation
BC375_RS04100	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BC375_RS04110	COG0328	RNA-DNA hybrid ribonuclease activity
BC375_RS04115	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BC375_RS04120	COG0631	protein serine/threonine phosphatase activity
BC375_RS04135	COG0859	PFAM glycosyl transferase family 9
BC375_RS04140	COG3642	lipopolysaccharide core region biosynthetic process
BC375_RS04155	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
BC375_RS04160	COG2967	ApaG domain
BC375_RS04165	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BC375_RS04170	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BC375_RS04175	COG0704	Plays a role in the regulation of phosphate uptake
BC375_RS04180	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BC375_RS04185	COG0581	inorganic phosphate transmembrane transporter activity
BC375_RS04190	COG0573	inorganic phosphate transmembrane transporter activity
BC375_RS04195	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BC375_RS04200	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BC375_RS04200	COG4651	solute:proton antiporter activity
BC375_RS04215	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
BC375_RS04225	COG0488	(ABC) transporter
BC375_RS04380	COG0445	tRNA wobble uridine modification
BC375_RS04420	COG1469	GTP cyclohydrolase I activity
BC375_RS04430	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BC375_RS04435	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BC375_RS04445	COG2902	Dehydrogenase
BC375_RS04450	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BC375_RS04490	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BC375_RS04495	COG4221	oxidoreductase activity
BC375_RS04500	COG3077	Addiction module antitoxin, RelB DinJ family
BC375_RS04505	COG3041	Addiction module toxin RelE StbE family
BC375_RS04575	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
BC375_RS04600	COG2925	Exonuclease
BC375_RS04615	COG0025	NhaP-type Na H and K H
BC375_RS04625	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
BC375_RS04635	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BC375_RS04655	COG3079	Belongs to the UPF0149 family
BC375_RS04660	COG0006	proline dipeptidase activity
BC375_RS04705	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BC375_RS04710	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
BC375_RS04745	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BC375_RS04750	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BC375_RS04760	COG0557	exoribonuclease II activity
BC375_RS04770	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BC375_RS04775	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
BC375_RS04780	COG0302	gtp cyclohydrolase
BC375_RS04790	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
BC375_RS04795	COG1289	transmembrane transporter activity
BC375_RS04805	COG0151	Belongs to the GarS family
BC375_RS04810	COG0138	bifunctional purine biosynthesis protein purh
BC375_RS04825	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
BC375_RS04835	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BC375_RS04855	COG0596	Alpha beta hydrolase
BC375_RS04860	COG0727	PFAM Uncharacterised protein family (UPF0153)
BC375_RS04870	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
BC375_RS04870	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BC375_RS04895	COG0189	ligase activity
BC375_RS04910	COG0840	transmembrane signaling receptor activity
BC375_RS04915	COG0784	Response regulator, receiver
BC375_RS04915	COG2198	Histidine kinase
BC375_RS04915	COG0643	Histidine kinase
BC375_RS04945	COG0285	dihydrofolate synthase activity
BC375_RS04955	COG0339	signal peptide processing
BC375_RS04980	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BC375_RS04985	COG1301	dicarboxylic acid transport
BC375_RS04990	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
BC375_RS04995	COG0357	Ribosomal RNA small subunit methyltransferase G
BC375_RS05000	COG2091	lysine biosynthetic process via aminoadipic acid
BC375_RS05075	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
BC375_RS05085	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BC375_RS05125	COG0084	hydrolase, TatD family'
BC375_RS05140	COG0552	protein localization to endoplasmic reticulum
BC375_RS05150	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
BC375_RS05160	COG0217	transcriptional regulatory protein
BC375_RS05165	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
BC375_RS05170	COG0632	four-way junction helicase activity
BC375_RS05175	COG3158	transport of potassium into the cell
BC375_RS05180	COG2255	four-way junction helicase activity
BC375_RS05185	COG0824	Thioesterase
BC375_RS05205	COG0823	Involved in the tonB-independent uptake of proteins
BC375_RS05210	COG2885	chlorophyll binding
BC375_RS05220	COG0602	queuosine metabolic process
BC375_RS05225	COG0588	phosphoglycerate mutase activity
BC375_RS05230	COG1515	deoxyribonuclease V activity
BC375_RS05250	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
BC375_RS05260	COG0406	alpha-ribazole phosphatase activity
BC375_RS05655	COG2337	Toxic component of a toxin-antitoxin (TA) module
BC375_RS05680	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
BC375_RS05685	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BC375_RS05725	COG0675	Transposase, IS605 OrfB family
BC375_RS05820	COG3772	lysozyme
BC375_RS05940	COG3617	BRO family, N-terminal domain
BC375_RS05970	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
BC375_RS05975	COG3852	Histidine kinase
BC375_RS05980	COG2204	response regulator
BC375_RS05995	COG0004	ammonium transporteR
BC375_RS06000	COG0347	Belongs to the P(II) protein family
BC375_RS06005	COG0174	glutamine synthetase
BC375_RS06010	COG1968	undecaprenyl-diphosphatase activity
BC375_RS06015	COG2353	YceI-like domain
BC375_RS06035	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
BC375_RS06070	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
BC375_RS06075	COG1764	response to oxidative stress
BC375_RS06085	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BC375_RS06095	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
BC375_RS06115	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BC375_RS06120	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BC375_RS06125	COG0333	Belongs to the bacterial ribosomal protein bL32 family
BC375_RS06130	COG1399	metal-binding, possibly nucleic acid-binding protein
BC375_RS06140	COG0714	Associated with various cellular activities
BC375_RS06160	COG0537	adenosine 5'-monophosphoramidase activity
BC375_RS06170	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
BC375_RS06190	COG0338	D12 class N6 adenine-specific DNA methyltransferase
BC375_RS06210	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BC375_RS06240	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
BC375_RS06280	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BC375_RS06285	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BC375_RS06290	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BC375_RS06295	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
BC375_RS06310	COG0251	oxidation-reduction process
BC375_RS06350	COG3657	addiction module killer protein
BC375_RS06355	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BC375_RS06450	COG2369	cell adhesion
BC375_RS06465	COG3567	Phage-associated protein, HI1409 family
BC375_RS06470	COG5410	chromosome segregation
BC375_RS06495	COG3772	lysozyme
BC375_RS06520	COG0305	Participates in initiation and elongation during chromosome replication
BC375_RS06545	COG3617	BRO family, N-terminal domain
BC375_RS06550	COG3617	BRO family, N-terminal domain
BC375_RS06670	COG0629	single-stranded DNA binding
BC375_RS06680	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
BC375_RS06685	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
BC375_RS06685	COG0392	lysyltransferase activity
BC375_RS06700	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BC375_RS06710	COG0463	Glycosyl transferase, family 2
BC375_RS06765	COG3275	phosphorelay sensor kinase activity
BC375_RS06775	COG2943	transferase activity, transferring hexosyl groups
BC375_RS06790	COG2226	methyltransferase
BC375_RS06805	COG2027	D-alanyl-D-alanine carboxypeptidase
BC375_RS06815	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BC375_RS06830	COG2900	Belongs to the SlyX family
BC375_RS06845	COG0386	Belongs to the glutathione peroxidase family
BC375_RS06855	COG1131	(ABC) transporter
BC375_RS06875	COG3657	addiction module killer protein
BC375_RS06880	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BC375_RS06935	COG3657	addiction module killer protein
BC375_RS06940	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BC375_RS07035	COG2369	cell adhesion
BC375_RS07050	COG3567	Phage-associated protein, HI1409 family
BC375_RS07055	COG5410	chromosome segregation
BC375_RS07080	COG3772	lysozyme
BC375_RS07130	COG0114	fumarate hydratase activity
BC375_RS07145	COG2850	peptidyl-arginine hydroxylation
BC375_RS07150	COG0567	Dehydrogenase, E1 component
BC375_RS07175	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
BC375_RS07195	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
BC375_RS07200	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BC375_RS07225	COG0583	DNA-binding transcription factor activity
BC375_RS07230	COG3634	alkyl hydroperoxide reductase activity
BC375_RS07250	COG1450	Type ii and iii secretion system protein
BC375_RS07265	COG3166	PFAM Fimbrial assembly family protein
BC375_RS07270	COG3156	type II secretion system protein K
BC375_RS07275	COG4795	General secretion pathway protein
BC375_RS07280	COG2165	general secretion pathway protein
BC375_RS07285	COG4970	Tfp pilus assembly protein FimT
BC375_RS07290	COG2165	general secretion pathway protein
BC375_RS07295	COG1459	type II secretion system
BC375_RS07300	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BC375_RS07305	COG5295	Hep Hag repeat protein
BC375_RS07325	COG2890	protein-(glutamine-N5) methyltransferase activity
BC375_RS07335	COG0596	Alpha beta hydrolase
BC375_RS07350	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BC375_RS07365	COG1561	YicC-like family, N-terminal region
BC375_RS07370	COG0194	GDP metabolic process
BC375_RS07375	COG1758	RNA polymerase activity
BC375_RS07380	COG0529	Catalyzes the synthesis of activated sulfate
BC375_RS07380	COG2895	sulfate adenylyltransferase (ATP) activity
BC375_RS07390	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BC375_RS07400	COG0175	sulfate reduction
BC375_RS07415	COG2912	Transglutaminase-like superfamily
BC375_RS07435	COG0308	aminopeptidase N
BC375_RS07440	COG2226	methyltransferase
BC375_RS07450	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
BC375_RS07470	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BC375_RS07490	COG1959	2 iron, 2 sulfur cluster binding
BC375_RS07495	COG0719	Fe-S assembly protein
BC375_RS07500	COG0396	ATPase activity
BC375_RS07505	COG0719	Fe-S assembly protein
BC375_RS07510	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BC375_RS07525	COG0297	glycogen (starch) synthase activity
BC375_RS07530	COG0726	polysaccharide deacetylase
BC375_RS07535	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BC375_RS07540	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
BC375_RS07545	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BC375_RS07550	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BC375_RS07555	COG1609	Transcriptional regulator
BC375_RS07570	COG0837	glucose binding
BC375_RS07585	COG1028	Short-chain dehydrogenase reductase Sdr
BC375_RS07590	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BC375_RS07595	COG4191	Histidine kinase
BC375_RS07600	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BC375_RS07605	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BC375_RS07610	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
BC375_RS07620	COG1674	ftsk spoiiie
BC375_RS07625	COG0492	ferredoxin-NADP+ reductase activity
BC375_RS07635	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
BC375_RS07640	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BC375_RS07650	COG0542	response to heat
BC375_RS07655	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
BC375_RS07670	COG2915	High frequency lysogenization protein hflD homolog
BC375_RS07680	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BC375_RS07700	COG0218	Necessary for normal cell division and for the maintenance of normal septation
BC375_RS07715	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BC375_RS07720	COG4974	Belongs to the 'phage' integrase family
BC375_RS07765	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BC375_RS07780	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
BC375_RS07795	COG1137	ATPase activity
BC375_RS07815	COG1660	Displays ATPase and GTPase activities
BC375_RS07830	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BC375_RS07850	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BC375_RS07855	COG0629	single-stranded DNA binding
BC375_RS07860	COG0142	geranyltranstransferase activity
BC375_RS07865	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BC375_RS07870	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BC375_RS07875	COG1845	cytochrome c oxidase, subunit III
BC375_RS07880	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
BC375_RS07885	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BC375_RS07885	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BC375_RS07900	COG1643	Atp-dependent helicase
BC375_RS07905	COG0783	Belongs to the Dps family
BC375_RS07910	COG0514	ATP-dependent DNA helicase (RecQ)
BC375_RS07920	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BC375_RS07930	COG0159	tryptophan synthase activity
BC375_RS07935	COG0133	tryptophan synthase activity
BC375_RS07940	COG0135	phosphoribosylanthranilate isomerase activity
BC375_RS07955	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BC375_RS07965	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BC375_RS07970	COG2890	protein-(glutamine-N5) methyltransferase activity
BC375_RS07975	COG1999	signal sequence binding
BC375_RS07990	COG0741	lytic transglycosylase activity
BC375_RS07995	COG0617	tRNA 3'-terminal CCA addition
BC375_RS08000	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BC375_RS08015	COG0156	8-amino-7-oxononanoate synthase activity
BC375_RS08020	COG2267	carboxylic ester hydrolase activity
BC375_RS08030	COG1846	Transcriptional regulator
BC375_RS08040	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BC375_RS08050	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
BC375_RS08055	COG4208	sulfate ABC transporter
BC375_RS08060	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
BC375_RS08075	COG3142	Participates in the control of copper homeostasis
BC375_RS08085	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BC375_RS08090	COG0259	pyridoxamine-phosphate oxidase activity
BC375_RS08100	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BC375_RS08105	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
BC375_RS08115	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
BC375_RS08130	COG2353	YceI-like domain
BC375_RS08145	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
BC375_RS08170	COG2894	cell division
BC375_RS08190	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BC375_RS08195	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
BC375_RS08200	COG0772	Belongs to the SEDS family
BC375_RS08205	COG0768	penicillin binding
BC375_RS08210	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
BC375_RS08215	COG1792	Involved in formation and maintenance of cell shape
BC375_RS08220	COG1077	Cell shape determining protein MreB Mrl
BC375_RS08265	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BC375_RS08270	COG1127	ABC transporter
BC375_RS08275	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BC375_RS08275	COG3218	ABC-type transport auxiliary lipoprotein component
BC375_RS08290	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
BC375_RS08290	COG0644	oxidoreductase
BC375_RS08300	COG2840	Smr protein MutS2
BC375_RS08305	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
BC375_RS08310	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
BC375_RS08315	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
BC375_RS08320	COG0148	phosphopyruvate hydratase activity
BC375_RS08325	COG2877	3-deoxy-8-phosphooctulonate synthase activity
BC375_RS08355	COG1253	flavin adenine dinucleotide binding
BC375_RS08360	COG2733	membrane
BC375_RS08385	COG0321	lipoyl(octanoyl) transferase activity
BC375_RS08390	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
BC375_RS08425	COG0668	transmembrane transport
BC375_RS08430	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
BC375_RS08450	COG2373	Large extracellular alpha-helical protein
BC375_RS08605	COG0582	viral genome integration into host DNA
BC375_RS08615	COG2911	Protein conserved in bacteria
BC375_RS08620	COG0729	surface antigen
BC375_RS08625	COG1956	GAF domain-containing protein
BC375_RS08630	COG1643	Atp-dependent helicase
BC375_RS08655	COG1131	(ABC) transporter
BC375_RS08660	COG0842	Transport permease protein
BC375_RS08700	COG1217	gtp-binding protein TYPA
BC375_RS08705	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BC375_RS08710	COG0039	L-malate dehydrogenase activity
BC375_RS08720	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BC375_RS08760	COG1187	pseudouridine synthase activity
BC375_RS08775	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BC375_RS08780	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BC375_RS08825	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BC375_RS08830	COG0740	serine-type endopeptidase activity
BC375_RS08835	COG0544	peptidyl-prolyl cis-trans isomerase activity
BC375_RS08850	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
BC375_RS08870	COG0606	chelatase, subunit chli
BC375_RS08875	COG2960	long-chain fatty acid transporting porin activity
BC375_RS08880	COG0203	ribosomal protein L17
BC375_RS08890	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BC375_RS08895	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BC375_RS08900	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BC375_RS08905	COG0201	protein transport
BC375_RS08910	COG0200	Binds to the 23S rRNA
BC375_RS08915	COG1841	ribosomal large subunit assembly
BC375_RS08920	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
BC375_RS08930	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BC375_RS08935	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
BC375_RS08940	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BC375_RS08945	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BC375_RS08950	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BC375_RS08960	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BC375_RS08965	COG0255	Belongs to the universal ribosomal protein uL29 family
BC375_RS08975	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BC375_RS08980	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
BC375_RS08985	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BC375_RS08990	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BC375_RS08995	COG0089	rRNA binding
BC375_RS09000	COG0088	Forms part of the polypeptide exit tunnel
BC375_RS09005	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BC375_RS09020	COG0356	it plays a direct role in the translocation of protons across the membrane
BC375_RS09030	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BC375_RS09035	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BC375_RS09040	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BC375_RS09045	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BC375_RS09050	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BC375_RS09055	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BC375_RS09065	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BC375_RS09080	COG1064	alcohol dehydrogenase
BC375_RS09095	COG0583	DNA-binding transcription factor activity
BC375_RS09100	COG0312	modulator of DNA gyrase
BC375_RS09105	COG3028	Belongs to the UPF0307 family
BC375_RS09110	COG0312	modulator of DNA gyrase
BC375_RS09125	COG0424	maF-like protein
BC375_RS09140	COG0494	nUDIX hydrolase
BC375_RS09150	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BC375_RS09160	COG0019	diaminopimelate decarboxylase activity
BC375_RS09165	COG1024	Enoyl-CoA hydratase
BC375_RS09180	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BC375_RS09190	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BC375_RS09200	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BC375_RS09210	COG0505	Belongs to the CarA family
BC375_RS09215	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BC375_RS09275	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BC375_RS09295	COG1663	tetraacyldisaccharide 4'-kinase activity
BC375_RS09300	COG1132	(ABC) transporter
BC375_RS09310	COG0811	peptide transport
BC375_RS09320	COG1136	(ABC) transporter
BC375_RS09325	COG4591	ABC-type transport system involved in lipoprotein release permease component
BC375_RS09340	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BC375_RS09350	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
BC375_RS09355	COG2009	succinate dehydrogenase
BC375_RS09365	COG0354	folic acid binding
BC375_RS09370	COG3842	ATPase activity
BC375_RS09375	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BC375_RS09380	COG0837	glucose binding
BC375_RS09385	COG0363	glucosamine-6-phosphate deaminase activity
BC375_RS09420	COG0528	UMP kinase activity
BC375_RS09445	COG2067	long-chain fatty acid transport protein
BC375_RS09450	COG0233	cytoplasmic translational termination
BC375_RS09455	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BC375_RS09460	COG0575	Belongs to the CDS family
BC375_RS09470	COG0750	zinc metalloprotease
BC375_RS09485	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BC375_RS09490	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BC375_RS09495	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BC375_RS09500	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BC375_RS09510	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
BC375_RS09530	COG2937	Belongs to the GPAT DAPAT family
BC375_RS09560	COG1946	Acyl-CoA thioesterase
BC375_RS09570	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
BC375_RS09580	COG1914	H( )-stimulated, divalent metal cation uptake system
BC375_RS09625	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
BC375_RS09635	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BC375_RS09640	COG0165	Argininosuccinate lyase
BC375_RS09650	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BC375_RS09655	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BC375_RS09660	COG0137	argininosuccinate synthase activity
BC375_RS09665	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BC375_RS09680	COG0215	cysteine-tRNA ligase activity
BC375_RS09685	COG2166	iron-sulfur cluster assembly
BC375_RS09705	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
BC375_RS09710	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BC375_RS09730	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
BC375_RS09740	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BC375_RS09745	COG0742	ribosomal rna small subunit methyltransferase
BC375_RS09750	COG0326	Molecular chaperone. Has ATPase activity
BC375_RS09755	COG0280	phosphate acetyltransferase
BC375_RS09755	COG0281	malic enzyme
BC375_RS09760	COG1301	dicarboxylic acid transport
BC375_RS09775	COG0784	Response regulator, receiver
BC375_RS09775	COG2205	protein histidine kinase activity
BC375_RS09810	COG0556	nucleotide-excision repair
BC375_RS09835	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BC375_RS09860	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
BC375_RS09865	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BC375_RS09885	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BC375_RS09885	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BC375_RS09905	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BC375_RS09910	COG0488	(ABC) transporter
BC375_RS09920	COG3011	Protein conserved in bacteria
BC375_RS09930	COG0564	pseudouridine synthase activity
BC375_RS09935	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BC375_RS09945	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
BC375_RS09945	COG1918	ferrous iron import across plasma membrane
BC375_RS09960	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
BC375_RS09970	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BC375_RS09985	COG0758	DNA mediated transformation
BC375_RS09990	COG2922	Belongs to the Smg family
BC375_RS10000	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BC375_RS10000	COG1754	DNA topoisomerase type I activity
BC375_RS10005	COG0009	L-threonylcarbamoyladenylate synthase
BC375_RS10035	COG2969	positive regulation of protein catabolic process
BC375_RS10040	COG0625	glutathione transferase activity
BC375_RS10045	COG2857	Cytochrome c1
BC375_RS10050	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
BC375_RS10055	COG0723	plastoquinol--plastocyanin reductase activity
BC375_RS10065	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BC375_RS10070	COG1702	phosphate starvation-inducible protein PhoH
BC375_RS10075	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
BC375_RS10085	COG4535	Mg2 and Co2 transporter CorC
BC375_RS10150	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BC375_RS10160	COG1199	ATP-dependent helicase activity
BC375_RS10170	COG0288	reversible hydration of carbon dioxide
BC375_RS10195	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BC375_RS10220	COG0508	dehydrogenase complex catalyzes the overall conversion of
BC375_RS10240	COG0626	cystathionine gamma-synthase activity
BC375_RS10245	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BC375_RS10250	COG0739	heme binding
BC375_RS10265	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
BC375_RS10270	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BC375_RS10275	COG1238	metal cluster binding
BC375_RS10290	COG5002	protein histidine kinase activity
BC375_RS10300	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BC375_RS10305	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BC375_RS10310	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BC375_RS10315	COG3858	chitin binding
BC375_RS10315	COG1388	LysM domain
BC375_RS10330	COG1472	Belongs to the glycosyl hydrolase 3 family
BC375_RS10345	COG3537	Alpha-1,2-mannosidase
BC375_RS10355	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
BC375_RS10360	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BC375_RS10365	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
BC375_RS10380	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BC375_RS10420	COG3588	fructose-bisphosphate aldolase
BC375_RS10430	COG0469	pyruvate kinase activity
BC375_RS10440	COG0126	phosphoglycerate kinase activity
BC375_RS10445	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BC375_RS10450	COG0735	belongs to the Fur family
BC375_RS10460	COG5297	Belongs to the glycosyl hydrolase family 6
BC375_RS10460	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BC375_RS10470	COG0612	Peptidase, M16
BC375_RS10485	COG4305	rare lipoprotein A
BC375_RS10490	COG0653	protein targeting
BC375_RS10495	COG0739	heme binding
BC375_RS10505	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
BC375_RS10525	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
BC375_RS10530	COG1181	Belongs to the D-alanine--D-alanine ligase family
BC375_RS10535	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BC375_RS10540	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BC375_RS10550	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BC375_RS10555	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BC375_RS10560	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BC375_RS10570	COG3116	cell division
BC375_RS10575	COG0275	rRNA processing
BC375_RS10595	COG0471	metal ion transport
BC375_RS10595	COG3273	potassium ion transport
BC375_RS10600	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BC375_RS10635	COG2755	lipolytic protein G-D-S-L family
BC375_RS10635	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
BC375_RS10665	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BC375_RS10695	COG0640	Transcriptional regulator
BC375_RS10700	COG2391	methyltransferase activity
BC375_RS10705	COG2391	methyltransferase activity
BC375_RS10710	COG0730	response to heat
BC375_RS10715	COG0717	Belongs to the dCTP deaminase family
BC375_RS10725	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BC375_RS10730	COG0860	N-Acetylmuramoyl-L-alanine amidase
BC375_RS10735	COG0802	atpase or kinase
BC375_RS10740	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
BC375_RS10740	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BC375_RS10775	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
BC375_RS10795	COG0776	regulation of translation
BC375_RS10800	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BC375_RS10800	COG0072	phenylalanine-tRNA ligase activity
BC375_RS10805	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BC375_RS10810	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
BC375_RS10820	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BC375_RS10825	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BC375_RS10850	COG0745	RESPONSE REGULATOR receiver
BC375_RS10855	COG0642	Histidine kinase
BC375_RS10860	COG0237	dephospho-CoA kinase activity
BC375_RS10865	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
BC375_RS10915	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BC375_RS10925	COG2831	hemolysin activation secretion protein
BC375_RS10950	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
BC375_RS10970	COG3115	cell septum assembly
BC375_RS10980	COG0359	binds to the 23S rRNA
BC375_RS10985	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BC375_RS10995	COG0316	Belongs to the HesB IscA family
BC375_RS11000	COG0017	Asparaginyl-tRNA synthetase
BC375_RS11030	COG0167	dihydroorotate dehydrogenase activity
BC375_RS11035	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BC375_RS11040	COG0697	spore germination
BC375_RS11045	COG0671	phosphoesterase, PA-phosphatase related
BC375_RS11050	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
BC375_RS11060	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
BC375_RS11065	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BC375_RS11080	COG1132	(ABC) transporter
BC375_RS11090	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BC375_RS11095	COG1538	Outer membrane efflux protein
BC375_RS11100	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BC375_RS11115	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
BC375_RS11140	COG0473	3-isopropylmalate dehydrogenase activity
BC375_RS11150	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BC375_RS11160	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
BC375_RS11170	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
BC375_RS11170	COG0316	Belongs to the HesB IscA family
BC375_RS11175	COG2154	pterin-4-alpha-carbinolamine dehydratase
BC375_RS11190	COG1530	ribonuclease E activity
BC375_RS11195	COG2197	response regulator
BC375_RS11200	COG1054	Belongs to the UPF0176 family
BC375_RS11215	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BC375_RS11230	COG0488	(ABC) transporter
BC375_RS11240	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
BC375_RS11245	COG1278	Cold shock
BC375_RS11255	COG0501	Belongs to the peptidase M48B family
BC375_RS11265	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BC375_RS11270	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BC375_RS11275	COG0049	tRNA binding
BC375_RS11285	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BC375_RS11290	COG0085	RNA polymerase activity
BC375_RS11295	COG0222	ribosome binding
BC375_RS11300	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BC375_RS11305	COG0081	regulation of translation
BC375_RS11310	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BC375_RS11315	COG0250	Participates in transcription elongation, termination and antitermination
BC375_RS11320	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BC375_RS11330	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BC375_RS11350	COG0012	GTP binding
BC375_RS11355	COG0193	aminoacyl-tRNA hydrolase activity
BC375_RS11375	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
BC375_RS11380	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
BC375_RS11390	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
BC375_RS11395	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BC375_RS11405	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BC375_RS11405	COG0116	Belongs to the methyltransferase superfamily
BC375_RS11455	COG2095	MarC family integral membrane protein
BC375_RS11465	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
BC375_RS11480	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BC375_RS11495	COG2132	Multicopper oxidase
BC375_RS11505	COG0210	DNA helicase
BC375_RS11510	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
BC375_RS11540	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BC375_RS11550	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BC375_RS11555	COG2201	protein-glutamate methylesterase activity
BC375_RS11560	COG2177	Part of the ABC transporter FtsEX involved in
BC375_RS11565	COG2884	Cell division ATP-binding protein ftsE
BC375_RS11570	COG0513	Belongs to the DEAD box helicase family
BC375_RS11575	COG3118	belongs to the thioredoxin family
BC375_RS11580	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
BC375_RS11595	COG0793	Belongs to the peptidase S41A family
BC375_RS11600	COG4942	peptidase
BC375_RS11615	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BC375_RS11620	COG0493	'glutamate synthase
BC375_RS11660	COG1028	Short-chain dehydrogenase reductase Sdr
BC375_RS11685	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
BC375_RS11730	COG1280	lysine exporter protein (LysE YggA)
BC375_RS11740	COG4942	peptidase
BC375_RS11770	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
BC375_RS11780	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
BC375_RS11875	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BC375_RS11880	COG3657	addiction module killer protein
BC375_RS11945	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BC375_RS11955	COG0706	membrane insertase activity
BC375_RS11960	COG0594	ribonuclease P activity
BC375_RS12010	COG3657	addiction module killer protein
BC375_RS12020	COG3609	addiction module antidote protein, CC2985 family
BC375_RS12030	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
BC375_RS12125	COG0629	single-stranded DNA binding
BC375_RS12135	COG4962	Type ii secretion system protein e
BC375_RS12150	COG3451	type IV secretory pathway VirB4