locus-tag	class	description
XFUD_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
XFUD_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
XFUD_RS00025	COG0187	DNA topoisomerase II activity
XFUD_RS00035	COG0501	Belongs to the peptidase M48B family
XFUD_RS00075	COG0408	coproporphyrinogen oxidase activity
XFUD_RS00105	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
XFUD_RS00120	COG4969	Belongs to the N-Me-Phe pilin family
XFUD_RS00150	COG0284	orotidine-5'-phosphate decarboxylase activity
XFUD_RS00165	COG1970	mechanosensitive ion channel activity
XFUD_RS00185	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
XFUD_RS00195	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
XFUD_RS00205	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
XFUD_RS00210	COG0511	ligase activity, forming carbon-carbon bonds
XFUD_RS00215	COG0439	Biotin carboxylase
XFUD_RS00220	COG0210	DNA helicase
XFUD_RS00230	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
XFUD_RS00230	COG1017	nitric oxide dioxygenase activity
XFUD_RS00245	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
XFUD_RS00255	COG1040	competence protein
XFUD_RS00260	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
XFUD_RS00265	COG1752	Esterase of the alpha-beta hydrolase superfamily
XFUD_RS00275	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
XFUD_RS00310	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
XFUD_RS00320	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
XFUD_RS00340	COG3539	Fimbrial protein
XFUD_RS00355	COG3121	Chaperone
XFUD_RS00360	COG3539	Fimbrial protein
XFUD_RS00365	COG1546	Belongs to the CinA family
XFUD_RS00370	COG0477	Major facilitator Superfamily
XFUD_RS00375	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
XFUD_RS00380	COG1923	regulation of RNA biosynthetic process
XFUD_RS00385	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
XFUD_RS00390	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
XFUD_RS00400	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
XFUD_RS00410	COG1534	Rna-binding protein
XFUD_RS00420	COG0129	dihydroxy-acid dehydratase activity
XFUD_RS00445	COG1560	Kdo2-lipid A biosynthetic process
XFUD_RS00450	COG1519	Transferase
XFUD_RS00460	COG0228	four-way junction DNA binding
XFUD_RS00465	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
XFUD_RS00470	COG0336	Belongs to the RNA methyltransferase TrmD family
XFUD_RS00475	COG0335	large ribosomal subunit rRNA binding
XFUD_RS00495	COG2171	N-acyltransferase activity
XFUD_RS00500	COG1393	Belongs to the ArsC family
XFUD_RS00505	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
XFUD_RS00510	COG0367	asparagine synthase
XFUD_RS00520	COG2070	2-Nitropropane dioxygenase
XFUD_RS00525	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
XFUD_RS00530	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
XFUD_RS00535	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
XFUD_RS00550	COG0339	signal peptide processing
XFUD_RS00565	COG2132	Multicopper oxidase
XFUD_RS00575	COG0525	valine-tRNA ligase activity
XFUD_RS00595	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
XFUD_RS00615	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
XFUD_RS00625	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
XFUD_RS00630	COG1166	arginine decarboxylase activity
XFUD_RS00635	COG4221	oxidoreductase activity
XFUD_RS00645	COG0018	arginyl-trna synthetase
XFUD_RS00650	COG2003	Belongs to the UPF0758 family
XFUD_RS00655	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
XFUD_RS00660	COG0756	dUTP diphosphatase activity
XFUD_RS00665	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
XFUD_RS00675	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
XFUD_RS00720	COG2223	nitrite transmembrane transporter activity
XFUD_RS00725	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
XFUD_RS00730	COG0739	heme binding
XFUD_RS00735	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
XFUD_RS00765	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
XFUD_RS00780	COG1028	Short-chain dehydrogenase reductase Sdr
XFUD_RS00785	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
XFUD_RS00790	COG1272	protein, Hemolysin III
XFUD_RS00795	COG0463	Glycosyl transferase, family 2
XFUD_RS00800	COG0084	hydrolase, TatD family'
XFUD_RS00815	COG0509	glycine decarboxylation via glycine cleavage system
XFUD_RS00820	COG0404	The glycine cleavage system catalyzes the degradation of glycine
XFUD_RS00830	COG0330	HflC and HflK could
XFUD_RS00835	COG3956	TIGRFAM MazG family protein
XFUD_RS00840	COG1218	3'(2'),5'-bisphosphate nucleotidase
XFUD_RS00845	COG0494	nUDIX hydrolase
XFUD_RS00855	COG1385	rRNA (uridine-N3-)-methyltransferase activity
XFUD_RS00865	COG0513	Belongs to the DEAD box helicase family
XFUD_RS00870	COG0720	synthase
XFUD_RS00905	COG1981	membrane
XFUD_RS00910	COG0825	malonyl-CoA metabolic process
XFUD_RS00915	COG0587	DNA-directed DNA polymerase activity
XFUD_RS00920	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
XFUD_RS00945	COG0512	Glutamine amidotransferase of anthranilate synthase
XFUD_RS00950	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
XFUD_RS00955	COG0134	indole-3-glycerol-phosphate synthase activity
XFUD_RS00980	COG0006	proline dipeptidase activity
XFUD_RS00995	COG0343	queuine tRNA-ribosyltransferase activity
XFUD_RS01000	COG1862	Preprotein translocase
XFUD_RS01005	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
XFUD_RS01020	COG0617	tRNA 3'-terminal CCA addition
XFUD_RS01030	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
XFUD_RS01035	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
XFUD_RS01040	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
XFUD_RS01045	COG0166	Belongs to the GPI family
XFUD_RS01060	COG0779	Required for maturation of 30S ribosomal subunits
XFUD_RS01065	COG0195	Participates in both transcription termination and antitermination
XFUD_RS01070	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
XFUD_RS01075	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
XFUD_RS01080	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
XFUD_RS01090	COG1185	polyribonucleotide nucleotidyltransferase activity
XFUD_RS01095	COG1733	regulation of RNA biosynthetic process
XFUD_RS01100	COG0702	epimerase
XFUD_RS01160	COG2086	electron transfer activity
XFUD_RS01190	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
XFUD_RS01230	COG0477	Major facilitator Superfamily
XFUD_RS01245	COG0563	adenylate kinase activity
XFUD_RS01250	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
XFUD_RS01255	COG0671	phosphoesterase, PA-phosphatase related
XFUD_RS01265	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
XFUD_RS01270	COG0628	permease
XFUD_RS01290	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
XFUD_RS01295	COG1090	epimerase
XFUD_RS01300	COG0318	PFAM AMP-dependent synthetase and ligase
XFUD_RS01325	COG1049	propionate catabolic process, 2-methylcitrate cycle
XFUD_RS01350	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
XFUD_RS01385	COG0149	triose-phosphate isomerase activity
XFUD_RS01400	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XFUD_RS01405	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XFUD_RS01410	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XFUD_RS01415	COG0649	NAD binding
XFUD_RS01420	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
XFUD_RS01425	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
XFUD_RS01430	COG1034	ATP synthesis coupled electron transport
XFUD_RS01435	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
XFUD_RS01450	COG0713	ATP synthesis coupled electron transport
XFUD_RS01465	COG1007	ATP synthesis coupled electron transport
XFUD_RS01470	COG1028	Short-chain dehydrogenase reductase Sdr
XFUD_RS01475	COG2851	Citrate transporter
XFUD_RS01490	COG0642	Histidine kinase
XFUD_RS01510	COG0675	Transposase, IS605 OrfB family
XFUD_RS01550	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
XFUD_RS01555	COG4206	TonB-dependent receptor
XFUD_RS01560	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
XFUD_RS01580	COG0277	FAD linked oxidase domain protein
XFUD_RS01585	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
XFUD_RS01595	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
XFUD_RS01600	COG2124	cytochrome p450
XFUD_RS01615	COG0305	Participates in initiation and elongation during chromosome replication
XFUD_RS01630	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
XFUD_RS01635	COG0667	Aldo Keto reductase
XFUD_RS01640	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
XFUD_RS01675	COG2194	sulfuric ester hydrolase activity
XFUD_RS01680	COG2124	cytochrome p450
XFUD_RS01685	COG0352	thiamine-phosphate diphosphorylase activity
XFUD_RS01695	COG0542	response to heat
XFUD_RS01715	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
XFUD_RS01740	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
XFUD_RS01755	COG0494	nUDIX hydrolase
XFUD_RS01765	COG2193	ferroxidase activity
XFUD_RS01785	COG3850	Histidine kinase
XFUD_RS01785	COG4999	Histidine kinase
XFUD_RS01785	COG3437	response regulator, receiver
XFUD_RS01785	COG2205	protein histidine kinase activity
XFUD_RS01820	COG0861	Integral membrane protein TerC family
XFUD_RS01825	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
XFUD_RS01830	COG0531	amino acid
XFUD_RS01840	COG1116	anion transmembrane transporter activity
XFUD_RS01845	COG1322	Protein conserved in bacteria
XFUD_RS01855	COG2853	Lipoprotein
XFUD_RS01870	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
XFUD_RS01875	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
XFUD_RS01880	COG1127	ABC transporter
XFUD_RS01890	COG1074	ATP-dependent DNA helicase activity
XFUD_RS01910	COG0180	Tryptophanyl-tRNA synthetase
XFUD_RS01915	COG0358	DNA primase activity
XFUD_RS01925	COG1610	YqeY-like protein
XFUD_RS01935	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
XFUD_RS01940	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
XFUD_RS01945	COG0668	transmembrane transport
XFUD_RS01965	COG1183	phosphatidylcholine synthase activity
XFUD_RS01975	COG0442	prolyl-tRNA aminoacylation
XFUD_RS02000	COG0604	alcohol dehydrogenase
XFUD_RS02005	COG0330	HflC and HflK could
XFUD_RS02010	COG0330	HflC and HflK could
XFUD_RS02020	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
XFUD_RS02025	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
XFUD_RS02030	COG0105	UTP biosynthetic process
XFUD_RS02035	COG0820	rRNA (adenine-C2-)-methyltransferase activity
XFUD_RS02055	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XFUD_RS02060	COG1160	GTP binding
XFUD_RS02065	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
XFUD_RS02080	COG4943	cyclic-guanylate-specific phosphodiesterase activity
XFUD_RS02090	COG4968	Prepilin-type N-terminal cleavage methylation domain
XFUD_RS02135	COG0629	single-stranded DNA binding
XFUD_RS02160	COG4969	Belongs to the N-Me-Phe pilin family
XFUD_RS02210	COG2856	Zn peptidase
XFUD_RS02230	COG4197	protein conserved in bacteria, prophage-related
XFUD_RS02285	COG0740	serine-type endopeptidase activity
XFUD_RS02300	COG3772	lysozyme
XFUD_RS02345	COG5449	Phage conserved hypothetical protein BR0599
XFUD_RS02470	COG2878	Part of a membrane complex involved in electron transport
XFUD_RS02475	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
XFUD_RS02475	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
XFUD_RS02485	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
XFUD_RS02490	COG3107	peptidoglycan biosynthetic process
XFUD_RS02495	COG0792	nuclease activity
XFUD_RS02500	COG1162	GTPase activity
XFUD_RS02505	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
XFUD_RS02520	COG0518	GMP synthase (glutamine-hydrolyzing) activity
XFUD_RS02520	COG0519	Catalyzes the synthesis of GMP from XMP
XFUD_RS02535	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
XFUD_RS02540	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
XFUD_RS02550	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
XFUD_RS02560	COG2974	May be involved in recombination
XFUD_RS02565	COG0037	tRNA processing
XFUD_RS02575	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
XFUD_RS02595	COG3590	peptidase
XFUD_RS02625	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
XFUD_RS02635	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
XFUD_RS02645	COG0628	permease
XFUD_RS02655	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
XFUD_RS02660	COG3178	'Phosphotransferase
XFUD_RS02665	COG1555	photosystem II stabilization
XFUD_RS02670	COG1477	protein flavinylation
XFUD_RS02690	COG3128	pkhd-type hydroxylase
XFUD_RS02695	COG4774	siderophore transport
XFUD_RS02715	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
XFUD_RS02730	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
XFUD_RS02740	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
XFUD_RS02765	COG0459	protein refolding
XFUD_RS02775	COG1324	tolerance protein
XFUD_RS02785	COG0351	phosphomethylpyrimidine kinase
XFUD_RS02785	COG0352	thiamine-phosphate diphosphorylase activity
XFUD_RS02795	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
XFUD_RS02905	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
XFUD_RS02920	COG2311	Membrane
XFUD_RS02930	COG0791	NLP P60 protein
XFUD_RS02935	COG0791	NLP P60 protein
XFUD_RS02945	COG1301	dicarboxylic acid transport
XFUD_RS02955	COG0037	tRNA processing
XFUD_RS02960	COG1722	exodeoxyribonuclease VII activity
XFUD_RS02965	COG0142	geranyltranstransferase activity
XFUD_RS03025	COG1028	Short-chain dehydrogenase reductase Sdr
XFUD_RS03040	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
XFUD_RS03045	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
XFUD_RS03220	COG3772	lysozyme
XFUD_RS03290	COG3093	addiction module antidote protein HigA
XFUD_RS03360	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
XFUD_RS03365	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
XFUD_RS03375	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
XFUD_RS03380	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
XFUD_RS03385	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
XFUD_RS03385	COG0072	phenylalanine-tRNA ligase activity
XFUD_RS03390	COG0776	regulation of translation
XFUD_RS03410	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
XFUD_RS03435	COG1570	exodeoxyribonuclease VII activity
XFUD_RS03440	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
XFUD_RS03440	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
XFUD_RS03445	COG0802	atpase or kinase
XFUD_RS03455	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
XFUD_RS03465	COG0717	Belongs to the dCTP deaminase family
XFUD_RS03470	COG0730	response to heat
XFUD_RS03475	COG2391	methyltransferase activity
XFUD_RS03480	COG2391	methyltransferase activity
XFUD_RS03485	COG0640	Transcriptional regulator
XFUD_RS03490	COG3453	Protein conserved in bacteria
XFUD_RS03490	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
XFUD_RS03515	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
XFUD_RS03540	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
XFUD_RS03540	COG2755	lipolytic protein G-D-S-L family
XFUD_RS03570	COG2022	thiamine diphosphate biosynthetic process
XFUD_RS03575	COG0220	tRNA (guanine-N7-)-methyltransferase activity
XFUD_RS03595	COG2001	Belongs to the MraZ family
XFUD_RS03600	COG0275	rRNA processing
XFUD_RS03605	COG3116	cell division
XFUD_RS03615	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
XFUD_RS03620	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
XFUD_RS03625	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
XFUD_RS03635	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
XFUD_RS03640	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
XFUD_RS03645	COG1181	Belongs to the D-alanine--D-alanine ligase family
XFUD_RS03650	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
XFUD_RS03660	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
XFUD_RS03670	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
XFUD_RS03680	COG0739	heme binding
XFUD_RS03685	COG0653	protein targeting
XFUD_RS03690	COG4305	rare lipoprotein A
XFUD_RS03705	COG0612	Peptidase, M16
XFUD_RS03715	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XFUD_RS03715	COG5297	Belongs to the glycosyl hydrolase family 6
XFUD_RS03725	COG0735	belongs to the Fur family
XFUD_RS03730	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
XFUD_RS03735	COG0126	phosphoglycerate kinase activity
XFUD_RS03745	COG0469	pyruvate kinase activity
XFUD_RS03755	COG3588	fructose-bisphosphate aldolase
XFUD_RS03785	COG0583	DNA-binding transcription factor activity
XFUD_RS03790	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XFUD_RS03795	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XFUD_RS03805	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
XFUD_RS03810	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
XFUD_RS03815	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
XFUD_RS03825	COG3537	Alpha-1,2-mannosidase
XFUD_RS03840	COG1472	Belongs to the glycosyl hydrolase 3 family
XFUD_RS03850	COG3525	Glycosyl hydrolase, family 20, catalytic domain
XFUD_RS03855	COG1388	LysM domain
XFUD_RS03855	COG3858	chitin binding
XFUD_RS03860	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
XFUD_RS03865	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XFUD_RS03870	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
XFUD_RS03880	COG5002	protein histidine kinase activity
XFUD_RS03895	COG1238	metal cluster binding
XFUD_RS03900	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
XFUD_RS03905	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
XFUD_RS03925	COG0739	heme binding
XFUD_RS03930	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
XFUD_RS03935	COG0626	cystathionine gamma-synthase activity
XFUD_RS03955	COG0508	dehydrogenase complex catalyzes the overall conversion of
XFUD_RS03970	COG1464	Belongs to the NlpA lipoprotein family
XFUD_RS03975	COG2011	ABC-type metal ion transport system permease component
XFUD_RS03980	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
XFUD_RS04005	COG0288	reversible hydration of carbon dioxide
XFUD_RS04015	COG1199	ATP-dependent helicase activity
XFUD_RS04025	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
XFUD_RS04130	COG4535	Mg2 and Co2 transporter CorC
XFUD_RS04140	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
XFUD_RS04145	COG1702	phosphate starvation-inducible protein PhoH
XFUD_RS04150	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
XFUD_RS04155	COG0741	lytic transglycosylase activity
XFUD_RS04160	COG0723	plastoquinol--plastocyanin reductase activity
XFUD_RS04165	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
XFUD_RS04170	COG2857	Cytochrome c1
XFUD_RS04180	COG2969	positive regulation of protein catabolic process
XFUD_RS04215	COG0009	L-threonylcarbamoyladenylate synthase
XFUD_RS04220	COG1754	DNA topoisomerase type I activity
XFUD_RS04220	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
XFUD_RS04225	COG2922	Belongs to the Smg family
XFUD_RS04230	COG0758	DNA mediated transformation
XFUD_RS04245	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
XFUD_RS04255	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
XFUD_RS04270	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
XFUD_RS04270	COG1918	ferrous iron import across plasma membrane
XFUD_RS04290	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XFUD_RS04295	COG0564	pseudouridine synthase activity
XFUD_RS04300	COG1496	oxidoreductase activity
XFUD_RS04305	COG3011	Protein conserved in bacteria
XFUD_RS04310	COG0579	oxidoreductase
XFUD_RS04315	COG0488	(ABC) transporter
XFUD_RS04320	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
XFUD_RS04330	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
XFUD_RS04335	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
XFUD_RS04335	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
XFUD_RS04350	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
XFUD_RS04355	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
XFUD_RS04360	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
XFUD_RS04380	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
XFUD_RS04390	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
XFUD_RS04405	COG0556	nucleotide-excision repair
XFUD_RS04455	COG1301	dicarboxylic acid transport
XFUD_RS04460	COG0281	malic enzyme
XFUD_RS04460	COG0280	phosphate acetyltransferase
XFUD_RS04465	COG0326	Molecular chaperone. Has ATPase activity
XFUD_RS04470	COG0742	ribosomal rna small subunit methyltransferase
XFUD_RS04475	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
XFUD_RS04485	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
XFUD_RS04505	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
XFUD_RS04510	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
XFUD_RS04530	COG2166	iron-sulfur cluster assembly
XFUD_RS04535	COG0215	cysteine-tRNA ligase activity
XFUD_RS04550	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
XFUD_RS04555	COG0137	argininosuccinate synthase activity
XFUD_RS04560	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
XFUD_RS04565	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
XFUD_RS04575	COG0165	Argininosuccinate lyase
XFUD_RS04580	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
XFUD_RS04585	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
XFUD_RS04630	COG1914	H( )-stimulated, divalent metal cation uptake system
XFUD_RS04640	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
XFUD_RS04650	COG1946	Acyl-CoA thioesterase
XFUD_RS04685	COG2937	Belongs to the GPAT DAPAT family
XFUD_RS04705	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
XFUD_RS04715	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
XFUD_RS04720	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XFUD_RS04725	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XFUD_RS04730	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
XFUD_RS04735	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XFUD_RS04745	COG0750	zinc metalloprotease
XFUD_RS04750	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
XFUD_RS04755	COG0575	Belongs to the CDS family
XFUD_RS04760	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
XFUD_RS04765	COG0233	cytoplasmic translational termination
XFUD_RS04770	COG2067	long-chain fatty acid transport protein
XFUD_RS04795	COG0528	UMP kinase activity
XFUD_RS04830	COG0363	glucosamine-6-phosphate deaminase activity
XFUD_RS04835	COG0837	glucose binding
XFUD_RS04840	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
XFUD_RS04845	COG3842	ATPase activity
XFUD_RS04850	COG0354	folic acid binding
XFUD_RS04860	COG2009	succinate dehydrogenase
XFUD_RS04865	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
XFUD_RS04875	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
XFUD_RS04880	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
XFUD_RS04890	COG4591	ABC-type transport system involved in lipoprotein release permease component
XFUD_RS04895	COG1136	(ABC) transporter
XFUD_RS04905	COG0811	peptide transport
XFUD_RS04915	COG1132	(ABC) transporter
XFUD_RS04920	COG1663	tetraacyldisaccharide 4'-kinase activity
XFUD_RS04940	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XFUD_RS04970	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
XFUD_RS05000	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
XFUD_RS05005	COG0505	Belongs to the CarA family
XFUD_RS05010	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
XFUD_RS05015	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
XFUD_RS05025	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
XFUD_RS05030	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
XFUD_RS05035	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
XFUD_RS05050	COG1024	Enoyl-CoA hydratase
XFUD_RS05055	COG0019	diaminopimelate decarboxylase activity
XFUD_RS05065	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
XFUD_RS05075	COG0494	nUDIX hydrolase
XFUD_RS05090	COG0424	maF-like protein
XFUD_RS05105	COG0312	modulator of DNA gyrase
XFUD_RS05110	COG3028	Belongs to the UPF0307 family
XFUD_RS05115	COG0312	modulator of DNA gyrase
XFUD_RS05120	COG0583	DNA-binding transcription factor activity
XFUD_RS05125	COG0655	NAD(P)H dehydrogenase (quinone) activity
XFUD_RS05135	COG1064	alcohol dehydrogenase
XFUD_RS05150	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
XFUD_RS05160	COG0355	proton-transporting ATP synthase activity, rotational mechanism
XFUD_RS05165	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
XFUD_RS05170	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
XFUD_RS05175	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
XFUD_RS05180	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
XFUD_RS05185	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
XFUD_RS05195	COG0356	it plays a direct role in the translocation of protons across the membrane
XFUD_RS05210	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
XFUD_RS05215	COG0088	Forms part of the polypeptide exit tunnel
XFUD_RS05220	COG0089	rRNA binding
XFUD_RS05225	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
XFUD_RS05230	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
XFUD_RS05235	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
XFUD_RS05240	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
XFUD_RS05250	COG0255	Belongs to the universal ribosomal protein uL29 family
XFUD_RS05255	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
XFUD_RS05265	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
XFUD_RS05270	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
XFUD_RS05275	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
XFUD_RS05280	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
XFUD_RS05285	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
XFUD_RS05295	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
XFUD_RS05300	COG1841	ribosomal large subunit assembly
XFUD_RS05305	COG0200	Binds to the 23S rRNA
XFUD_RS05310	COG0201	protein transport
XFUD_RS05315	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
XFUD_RS05320	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
XFUD_RS05325	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
XFUD_RS05335	COG0203	ribosomal protein L17
XFUD_RS05340	COG2960	long-chain fatty acid transporting porin activity
XFUD_RS05345	COG0606	chelatase, subunit chli
XFUD_RS05355	COG5380	lipid catabolic process
XFUD_RS05365	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
XFUD_RS05380	COG0544	peptidyl-prolyl cis-trans isomerase activity
XFUD_RS05385	COG0740	serine-type endopeptidase activity
XFUD_RS05390	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
XFUD_RS05400	COG0776	regulation of translation
XFUD_RS05435	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
XFUD_RS05440	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
XFUD_RS05490	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XFUD_RS05495	COG0625	glutathione transferase activity
XFUD_RS05500	COG0039	L-malate dehydrogenase activity
XFUD_RS05505	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
XFUD_RS05510	COG1217	gtp-binding protein TYPA
XFUD_RS05555	COG1131	(ABC) transporter
XFUD_RS05580	COG1643	Atp-dependent helicase
XFUD_RS05585	COG1956	GAF domain-containing protein
XFUD_RS05590	COG0729	surface antigen
XFUD_RS05595	COG2911	Protein conserved in bacteria
XFUD_RS05690	COG2373	Large extracellular alpha-helical protein
XFUD_RS05710	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
XFUD_RS05715	COG0668	transmembrane transport
XFUD_RS05725	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
XFUD_RS05755	COG5297	Belongs to the glycosyl hydrolase family 6
XFUD_RS05760	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
XFUD_RS05765	COG0321	lipoyl(octanoyl) transferase activity
XFUD_RS05770	COG2921	Belongs to the UPF0250 family
XFUD_RS05790	COG2733	membrane
XFUD_RS05795	COG1253	flavin adenine dinucleotide binding
XFUD_RS05825	COG0504	CTP synthase activity
XFUD_RS05830	COG2877	3-deoxy-8-phosphooctulonate synthase activity
XFUD_RS05835	COG0148	phosphopyruvate hydratase activity
XFUD_RS05840	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
XFUD_RS05845	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
XFUD_RS05850	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
XFUD_RS05855	COG2840	Smr protein MutS2
XFUD_RS05865	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
XFUD_RS05865	COG0644	oxidoreductase
XFUD_RS05880	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
XFUD_RS05880	COG3218	ABC-type transport auxiliary lipoprotein component
XFUD_RS05885	COG1127	ABC transporter
XFUD_RS05890	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
XFUD_RS05935	COG1077	Cell shape determining protein MreB Mrl
XFUD_RS05940	COG1792	Involved in formation and maintenance of cell shape
XFUD_RS05945	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
XFUD_RS05950	COG0768	penicillin binding
XFUD_RS05955	COG0772	Belongs to the SEDS family
XFUD_RS05960	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
XFUD_RS05965	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
XFUD_RS05985	COG2894	cell division
XFUD_RS05990	COG0850	regulation of cytokinetic process
XFUD_RS06010	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
XFUD_RS06020	COG3038	cytochrome b561
XFUD_RS06025	COG2353	YceI-like domain
XFUD_RS06030	COG2198	Histidine kinase
XFUD_RS06030	COG2205	protein histidine kinase activity
XFUD_RS06030	COG0784	Response regulator, receiver
XFUD_RS06040	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
XFUD_RS06050	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
XFUD_RS06055	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
XFUD_RS06065	COG0259	pyridoxamine-phosphate oxidase activity
XFUD_RS06070	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
XFUD_RS06095	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
XFUD_RS06100	COG4208	sulfate ABC transporter
XFUD_RS06105	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
XFUD_RS06115	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
XFUD_RS06125	COG1846	Transcriptional regulator
XFUD_RS06135	COG2267	carboxylic ester hydrolase activity
XFUD_RS06140	COG0156	8-amino-7-oxononanoate synthase activity
XFUD_RS06150	COG0109	protoheme IX farnesyltransferase activity
XFUD_RS06155	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
XFUD_RS06160	COG0617	tRNA 3'-terminal CCA addition
XFUD_RS06165	COG0741	lytic transglycosylase activity
XFUD_RS06175	COG0688	phosphatidylethanolamine metabolic process
XFUD_RS06185	COG2890	protein-(glutamine-N5) methyltransferase activity
XFUD_RS06190	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
XFUD_RS06200	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
XFUD_RS06210	COG0101	tRNA pseudouridine synthase activity
XFUD_RS06215	COG0135	phosphoribosylanthranilate isomerase activity
XFUD_RS06220	COG0133	tryptophan synthase activity
XFUD_RS06225	COG0159	tryptophan synthase activity
XFUD_RS06235	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
XFUD_RS06245	COG0514	ATP-dependent DNA helicase (RecQ)
XFUD_RS06250	COG0783	Belongs to the Dps family
XFUD_RS06255	COG1643	Atp-dependent helicase
XFUD_RS06270	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
XFUD_RS06270	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
XFUD_RS06275	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
XFUD_RS06280	COG1845	cytochrome c oxidase, subunit III
XFUD_RS06285	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
XFUD_RS06290	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
XFUD_RS06295	COG0142	geranyltranstransferase activity
XFUD_RS06300	COG0629	single-stranded DNA binding
XFUD_RS06305	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
XFUD_RS06325	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
XFUD_RS06330	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
XFUD_RS06340	COG1660	Displays ATPase and GTPase activities
XFUD_RS06360	COG1137	ATPase activity
XFUD_RS06375	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
XFUD_RS06385	COG0271	Belongs to the BolA IbaG family
XFUD_RS06390	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
XFUD_RS06430	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
XFUD_RS06430	COG0047	phosphoribosylformylglycinamidine synthase activity
XFUD_RS06435	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
XFUD_RS06440	COG4974	Belongs to the 'phage' integrase family
XFUD_RS06445	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
XFUD_RS06450	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
XFUD_RS06460	COG0218	Necessary for normal cell division and for the maintenance of normal septation
XFUD_RS06490	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
XFUD_RS06500	COG2915	High frequency lysogenization protein hflD homolog
XFUD_RS06515	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
XFUD_RS06520	COG0542	response to heat
XFUD_RS06530	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
XFUD_RS06535	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
XFUD_RS06545	COG0492	ferredoxin-NADP+ reductase activity
XFUD_RS06550	COG1674	ftsk spoiiie
XFUD_RS06560	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
XFUD_RS06565	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
XFUD_RS06570	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
XFUD_RS06575	COG4191	Histidine kinase
XFUD_RS06580	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
XFUD_RS06585	COG1028	Short-chain dehydrogenase reductase Sdr
XFUD_RS06600	COG0837	glucose binding
XFUD_RS06615	COG1609	Transcriptional regulator
XFUD_RS06620	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
XFUD_RS06625	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
XFUD_RS06630	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
XFUD_RS06635	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
XFUD_RS06640	COG0726	polysaccharide deacetylase
XFUD_RS06645	COG0297	glycogen (starch) synthase activity
XFUD_RS06660	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
XFUD_RS06665	COG0719	Fe-S assembly protein
XFUD_RS06670	COG0396	ATPase activity
XFUD_RS06675	COG0719	Fe-S assembly protein
XFUD_RS06680	COG1959	2 iron, 2 sulfur cluster binding
XFUD_RS06700	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
XFUD_RS06720	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
XFUD_RS06730	COG2226	methyltransferase
XFUD_RS06735	COG0308	aminopeptidase N
XFUD_RS06760	COG2912	Transglutaminase-like superfamily
XFUD_RS06775	COG0175	sulfate reduction
XFUD_RS06780	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
XFUD_RS06790	COG0175	sulfate reduction
XFUD_RS06795	COG2895	sulfate adenylyltransferase (ATP) activity
XFUD_RS06795	COG0529	Catalyzes the synthesis of activated sulfate
XFUD_RS06800	COG1758	RNA polymerase activity
XFUD_RS06805	COG0194	GDP metabolic process
XFUD_RS06810	COG1561	YicC-like family, N-terminal region
XFUD_RS06815	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
XFUD_RS06820	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
XFUD_RS06825	COG0635	Involved in the biosynthesis of porphyrin-containing compound
XFUD_RS06840	COG0596	Alpha beta hydrolase
XFUD_RS06850	COG2890	protein-(glutamine-N5) methyltransferase activity
XFUD_RS06865	COG5295	Hep Hag repeat protein
XFUD_RS06870	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
XFUD_RS06875	COG1459	type II secretion system
XFUD_RS06880	COG2165	general secretion pathway protein
XFUD_RS06885	COG4970	Tfp pilus assembly protein FimT
XFUD_RS06890	COG2165	general secretion pathway protein
XFUD_RS06895	COG4795	General secretion pathway protein
XFUD_RS06900	COG3156	type II secretion system protein K
XFUD_RS06905	COG3166	PFAM Fimbrial assembly family protein
XFUD_RS06920	COG1450	Type ii and iii secretion system protein
XFUD_RS06940	COG3634	alkyl hydroperoxide reductase activity
XFUD_RS06945	COG0583	DNA-binding transcription factor activity
XFUD_RS06965	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
XFUD_RS06970	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
XFUD_RS06975	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
XFUD_RS06995	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
XFUD_RS07020	COG0567	Dehydrogenase, E1 component
XFUD_RS07025	COG2850	peptidyl-arginine hydroxylation
XFUD_RS07040	COG0114	fumarate hydratase activity
XFUD_RS07075	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
XFUD_RS07095	COG3772	lysozyme
XFUD_RS07125	COG3567	Phage-associated protein, HI1409 family
XFUD_RS07140	COG2369	cell adhesion
XFUD_RS07215	COG1487	ribonuclease activity
XFUD_RS07220	COG4691	Plasmid stability protein
XFUD_RS07250	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
XFUD_RS07255	COG3657	addiction module killer protein
XFUD_RS07275	COG1131	(ABC) transporter
XFUD_RS07280	COG0386	Belongs to the glutathione peroxidase family
XFUD_RS07295	COG2900	Belongs to the SlyX family
XFUD_RS07310	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
XFUD_RS07320	COG2027	D-alanyl-D-alanine carboxypeptidase
XFUD_RS07335	COG2226	methyltransferase
XFUD_RS07350	COG2943	transferase activity, transferring hexosyl groups
XFUD_RS07360	COG3275	phosphorelay sensor kinase activity
XFUD_RS07370	COG0181	hydroxymethylbilane synthase activity
XFUD_RS07420	COG0463	Glycosyl transferase, family 2
XFUD_RS07430	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
XFUD_RS07445	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
XFUD_RS07445	COG0392	lysyltransferase activity
XFUD_RS07450	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
XFUD_RS07460	COG0629	single-stranded DNA binding
XFUD_RS07485	COG5532	Uncharacterized conserved protein (DUF2303)
XFUD_RS07585	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
XFUD_RS07605	COG3772	lysozyme
XFUD_RS07650	COG2369	cell adhesion
XFUD_RS07765	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
XFUD_RS07770	COG3657	addiction module killer protein
XFUD_RS07810	COG0251	oxidation-reduction process
XFUD_RS07830	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
XFUD_RS07835	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
XFUD_RS07840	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
XFUD_RS07850	COG0582	viral genome integration into host DNA
XFUD_RS07860	COG1396	sequence-specific DNA binding
XFUD_RS07870	COG0583	DNA-binding transcription factor activity
XFUD_RS07875	COG0667	Aldo Keto reductase
XFUD_RS07880	COG0667	Aldo Keto reductase
XFUD_RS07885	COG1942	4-Oxalocrotonate Tautomerase
XFUD_RS07905	COG0667	Aldo Keto reductase
XFUD_RS07910	COG0583	DNA-binding transcription factor activity
XFUD_RS07915	COG1902	pentaerythritol trinitrate reductase activity
XFUD_RS07925	COG1064	alcohol dehydrogenase
XFUD_RS07955	COG2133	pyrroloquinoline quinone binding
XFUD_RS07960	COG1028	Short-chain dehydrogenase reductase Sdr
XFUD_RS07965	COG3386	PFAM SMP-30 Gluconolaconase
XFUD_RS07975	COG4221	oxidoreductase activity
XFUD_RS07985	COG1064	alcohol dehydrogenase
XFUD_RS08160	COG0270	DNA (cytosine-5-)-methyltransferase activity
XFUD_RS08170	COG0629	single-stranded DNA binding
XFUD_RS08260	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
XFUD_RS08265	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
XFUD_RS08265	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
XFUD_RS08290	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
XFUD_RS08295	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
XFUD_RS08300	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
XFUD_RS08310	COG0338	D12 class N6 adenine-specific DNA methyltransferase
XFUD_RS08330	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
XFUD_RS08335	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
XFUD_RS08340	COG0537	adenosine 5'-monophosphoramidase activity
XFUD_RS08360	COG0714	Associated with various cellular activities
XFUD_RS08370	COG1399	metal-binding, possibly nucleic acid-binding protein
XFUD_RS08375	COG0333	Belongs to the bacterial ribosomal protein bL32 family
XFUD_RS08380	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
XFUD_RS08385	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
XFUD_RS08405	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
XFUD_RS08415	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
XFUD_RS08420	COG1764	response to oxidative stress
XFUD_RS08425	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
XFUD_RS08450	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
XFUD_RS08460	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
XFUD_RS08480	COG2353	YceI-like domain
XFUD_RS08485	COG1968	undecaprenyl-diphosphatase activity
XFUD_RS08490	COG0174	glutamine synthetase
XFUD_RS08495	COG0347	Belongs to the P(II) protein family
XFUD_RS08500	COG0004	ammonium transporteR
XFUD_RS08510	COG2204	response regulator
XFUD_RS08515	COG3852	Histidine kinase
XFUD_RS08555	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
XFUD_RS08560	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
XFUD_RS08585	COG2337	Toxic component of a toxin-antitoxin (TA) module
XFUD_RS08705	COG0406	alpha-ribazole phosphatase activity
XFUD_RS08715	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
XFUD_RS08725	COG0386	Belongs to the glutathione peroxidase family
XFUD_RS08735	COG1515	deoxyribonuclease V activity
XFUD_RS08740	COG0588	phosphoglycerate mutase activity
XFUD_RS08745	COG0602	queuosine metabolic process
XFUD_RS08755	COG2885	chlorophyll binding
XFUD_RS08760	COG0823	Involved in the tonB-independent uptake of proteins
XFUD_RS08780	COG0824	Thioesterase
XFUD_RS08785	COG2255	four-way junction helicase activity
XFUD_RS08790	COG3158	transport of potassium into the cell
XFUD_RS08795	COG0632	four-way junction helicase activity
XFUD_RS08800	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
XFUD_RS08805	COG0217	transcriptional regulatory protein
XFUD_RS08815	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
XFUD_RS08825	COG0552	protein localization to endoplasmic reticulum
XFUD_RS08840	COG0084	hydrolase, TatD family'
XFUD_RS08875	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
XFUD_RS08880	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
XFUD_RS08890	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
XFUD_RS08895	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
XFUD_RS08960	COG2091	lysine biosynthetic process via aminoadipic acid
XFUD_RS08965	COG0357	Ribosomal RNA small subunit methyltransferase G
XFUD_RS08970	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
XFUD_RS08975	COG1301	dicarboxylic acid transport
XFUD_RS08980	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
XFUD_RS09005	COG0339	signal peptide processing
XFUD_RS09015	COG0285	dihydrofolate synthase activity
XFUD_RS09045	COG2198	Histidine kinase
XFUD_RS09045	COG0784	Response regulator, receiver
XFUD_RS09045	COG0643	Histidine kinase
XFUD_RS09050	COG0840	transmembrane signaling receptor activity
XFUD_RS09065	COG0189	ligase activity
XFUD_RS09080	COG0751	glycine-tRNA ligase activity
XFUD_RS09085	COG0752	glycyl-tRNA synthetase alpha subunit
XFUD_RS09090	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
XFUD_RS09090	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
XFUD_RS09100	COG0727	PFAM Uncharacterised protein family (UPF0153)
XFUD_RS09105	COG0596	Alpha beta hydrolase
XFUD_RS09125	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
XFUD_RS09135	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
XFUD_RS09150	COG0138	bifunctional purine biosynthesis protein purh
XFUD_RS09155	COG0151	Belongs to the GarS family
XFUD_RS09165	COG1289	transmembrane transporter activity
XFUD_RS09170	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
XFUD_RS09185	COG0302	gtp cyclohydrolase
XFUD_RS09190	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
XFUD_RS09195	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
XFUD_RS09205	COG0557	exoribonuclease II activity
XFUD_RS09215	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
XFUD_RS09220	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
XFUD_RS09255	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
XFUD_RS09260	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
XFUD_RS09305	COG0006	proline dipeptidase activity
XFUD_RS09310	COG3079	Belongs to the UPF0149 family
XFUD_RS09330	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
XFUD_RS09340	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
XFUD_RS09350	COG0025	NhaP-type Na H and K H
XFUD_RS09365	COG2925	Exonuclease
XFUD_RS09390	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
XFUD_RS09635	COG3609	addiction module antidote protein, CC2985 family
XFUD_RS09640	COG4691	Plasmid stability protein
XFUD_RS09675	COG3041	Addiction module toxin RelE StbE family
XFUD_RS09680	COG3077	Addiction module antitoxin, RelB DinJ family
XFUD_RS09685	COG1028	Short-chain dehydrogenase reductase Sdr
XFUD_RS09690	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XFUD_RS09725	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
XFUD_RS09740	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XFUD_RS09745	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XFUD_RS09755	COG1469	GTP cyclohydrolase I activity
XFUD_RS09795	COG0445	tRNA wobble uridine modification
XFUD_RS09955	COG0488	(ABC) transporter
XFUD_RS09965	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
XFUD_RS09980	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
XFUD_RS09980	COG4651	solute:proton antiporter activity
XFUD_RS09985	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
XFUD_RS09990	COG0573	inorganic phosphate transmembrane transporter activity
XFUD_RS09995	COG0581	inorganic phosphate transmembrane transporter activity
XFUD_RS10000	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
XFUD_RS10005	COG0704	Plays a role in the regulation of phosphate uptake
XFUD_RS10010	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
XFUD_RS10015	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
XFUD_RS10020	COG2967	ApaG domain
XFUD_RS10025	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
XFUD_RS10040	COG3642	lipopolysaccharide core region biosynthetic process
XFUD_RS10045	COG0859	PFAM glycosyl transferase family 9
XFUD_RS10060	COG0631	protein serine/threonine phosphatase activity
XFUD_RS10065	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
XFUD_RS10070	COG0328	RNA-DNA hybrid ribonuclease activity
XFUD_RS10080	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
XFUD_RS10095	COG2183	response to ionizing radiation
XFUD_RS10110	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
XFUD_RS10120	COG3118	belongs to the thioredoxin family
XFUD_RS10130	COG0495	leucyl-tRNA aminoacylation
XFUD_RS10145	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
XFUD_RS10175	COG2951	lytic endotransglycosylase activity
XFUD_RS10225	COG3210	domain, Protein
XFUD_RS10250	COG2264	protein methyltransferase activity
XFUD_RS10260	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
XFUD_RS10265	COG0277	FAD linked oxidase domain protein
XFUD_RS10270	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
XFUD_RS10275	COG0531	amino acid
XFUD_RS10280	COG0531	amino acid
XFUD_RS10285	COG0235	Class ii aldolase
XFUD_RS10290	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
XFUD_RS10295	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
XFUD_RS10300	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
XFUD_RS10300	COG0140	phosphoribosyl-ATP diphosphatase activity
XFUD_RS10305	COG0107	imidazoleglycerol-phosphate synthase activity
XFUD_RS10310	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
XFUD_RS10315	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
XFUD_RS10320	COG0131	Imidazoleglycerol-phosphate dehydratase
XFUD_RS10320	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
XFUD_RS10325	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
XFUD_RS10330	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
XFUD_RS10335	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
XFUD_RS10345	COG0124	histidyl-tRNA synthetase
XFUD_RS10355	COG0083	homoserine kinase activity
XFUD_RS10360	COG0527	aspartate kinase activity
XFUD_RS10360	COG0460	homoserine dehydrogenase
XFUD_RS10365	COG0540	Belongs to the ATCase OTCase family
XFUD_RS10375	COG1678	Uncharacterized ACR, COG1678
XFUD_RS10385	COG1686	Belongs to the peptidase S11 family
XFUD_RS10395	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
XFUD_RS10410	COG4953	penicillin-binding protein 1C
XFUD_RS10440	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
XFUD_RS10445	COG0481	GTPase activity
XFUD_RS10460	COG0571	ribonuclease III activity
XFUD_RS10465	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
XFUD_RS10470	COG1381	Involved in DNA repair and RecF pathway recombination
XFUD_RS10475	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
XFUD_RS10490	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
XFUD_RS10495	COG1971	Probably functions as a manganese efflux pump
XFUD_RS10505	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XFUD_RS10510	COG0823	Involved in the tonB-independent uptake of proteins
XFUD_RS10510	COG1506	peptidase
XFUD_RS10515	COG1297	OPT oligopeptide transporter protein
XFUD_RS10535	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
XFUD_RS10545	COG0676	glucose-6-phosphate 1-epimerase activity
XFUD_RS10555	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
XFUD_RS10560	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
XFUD_RS10570	COG0318	PFAM AMP-dependent synthetase and ligase
XFUD_RS10580	COG0463	Glycosyl transferase, family 2
XFUD_RS10590	COG1475	DNA binding
XFUD_RS10595	COG1192	Involved in chromosome partitioning
XFUD_RS10605	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
XFUD_RS10660	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
XFUD_RS10665	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
XFUD_RS10670	COG0489	protein tyrosine kinase activity
XFUD_RS10675	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
XFUD_RS10720	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
XFUD_RS10725	COG0322	excinuclease ABC activity
XFUD_RS10740	COG3772	lysozyme
XFUD_RS10780	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
XFUD_RS10785	COG1605	Chorismate mutase
XFUD_RS10785	COG0077	Prephenate dehydratase
XFUD_RS10790	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
XFUD_RS10800	COG1668	transmembrane transport
XFUD_RS10805	COG4555	ABC transporter
XFUD_RS10820	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
XFUD_RS10825	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
XFUD_RS10830	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
XFUD_RS10850	COG1605	Chorismate mutase
XFUD_RS10850	COG0287	Prephenate dehydrogenase
XFUD_RS10860	COG0443	Heat shock 70 kDa protein
XFUD_RS10865	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
XFUD_RS10875	COG0497	DNA recombination
XFUD_RS10885	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XFUD_RS10890	COG2914	Belongs to the UPF0125 (RnfH) family
XFUD_RS10900	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
XFUD_RS10910	COG1278	Cold shock
XFUD_RS10920	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
XFUD_RS10930	COG2954	triphosphatase activity
XFUD_RS10935	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
XFUD_RS10940	COG0745	RESPONSE REGULATOR receiver
XFUD_RS10945	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
XFUD_RS10950	COG0438	transferase activity, transferring glycosyl groups
XFUD_RS10965	COG0438	transferase activity, transferring glycosyl groups
XFUD_RS10995	COG0473	3-isopropylmalate dehydrogenase activity
XFUD_RS11000	COG0066	3-isopropylmalate dehydratase activity
XFUD_RS11005	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
XFUD_RS11025	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
XFUD_RS11025	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
XFUD_RS11030	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XFUD_RS11035	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XFUD_RS11050	COG1064	alcohol dehydrogenase
XFUD_RS11070	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
XFUD_RS11140	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
XFUD_RS11140	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XFUD_RS11175	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
XFUD_RS11185	COG0196	riboflavin kinase activity
XFUD_RS11190	COG0728	peptidoglycan biosynthetic process
XFUD_RS11195	COG0268	Binds directly to 16S ribosomal RNA
XFUD_RS11200	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
XFUD_RS11205	COG0211	Belongs to the bacterial ribosomal protein bL27 family
XFUD_RS11210	COG0261	This protein binds to 23S rRNA in the presence of protein L20
XFUD_RS11230	COG0518	GMP synthase (glutamine-hydrolyzing) activity
XFUD_RS11230	COG0519	Catalyzes the synthesis of GMP from XMP
XFUD_RS11240	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
XFUD_RS11245	COG1210	Utp--glucose-1-phosphate uridylyltransferase
XFUD_RS11260	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
XFUD_RS11270	COG0776	regulation of translation
XFUD_RS11280	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
XFUD_RS11315	COG0395	ABC-type sugar transport system, permease component
XFUD_RS11320	COG1175	transmembrane transport
XFUD_RS11345	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
XFUD_RS11350	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
XFUD_RS11355	COG1187	pseudouridine synthase activity
XFUD_RS11370	COG0436	Aminotransferase
XFUD_RS11375	COG4133	protoheme IX ABC transporter activity
XFUD_RS11395	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
XFUD_RS11405	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
XFUD_RS11425	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
XFUD_RS11445	COG0546	phosphoglycolate phosphatase activity
XFUD_RS11450	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
XFUD_RS11455	COG0402	S-adenosylhomocysteine deaminase activity
XFUD_RS11465	COG1509	lysine 2,3-aminomutase activity
XFUD_RS11475	COG0483	inositol monophosphate 1-phosphatase activity
XFUD_RS11480	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
XFUD_RS11550	COG2944	sequence-specific DNA binding
XFUD_RS11620	COG3772	lysozyme
XFUD_RS11735	COG3617	BRO family, N-terminal domain
XFUD_RS11765	COG0582	viral genome integration into host DNA
XFUD_RS11785	COG0745	RESPONSE REGULATOR receiver
XFUD_RS11790	COG0642	Histidine kinase
XFUD_RS11795	COG0237	dephospho-CoA kinase activity
XFUD_RS11800	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
XFUD_RS11845	COG0045	succinate-CoA ligase (ADP-forming) activity
XFUD_RS11850	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
XFUD_RS11860	COG2831	hemolysin activation secretion protein
XFUD_RS11875	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
XFUD_RS11885	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
XFUD_RS11895	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
XFUD_RS11900	COG3115	cell septum assembly
XFUD_RS11910	COG0359	binds to the 23S rRNA
XFUD_RS11915	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
XFUD_RS11925	COG0316	Belongs to the HesB IscA family
XFUD_RS11930	COG0017	Asparaginyl-tRNA synthetase
XFUD_RS11960	COG0167	dihydroorotate dehydrogenase activity
XFUD_RS11965	COG0812	UDP-N-acetylmuramate dehydrogenase activity
XFUD_RS11970	COG0697	spore germination
XFUD_RS11980	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
XFUD_RS11995	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
XFUD_RS12000	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
XFUD_RS12015	COG1132	(ABC) transporter
XFUD_RS12025	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
XFUD_RS12030	COG1538	Outer membrane efflux protein
XFUD_RS12035	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XFUD_RS12050	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
XFUD_RS12065	COG4783	chaperone-mediated protein folding
XFUD_RS12075	COG0473	3-isopropylmalate dehydrogenase activity
XFUD_RS12085	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
XFUD_RS12095	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
XFUD_RS12105	COG0316	Belongs to the HesB IscA family
XFUD_RS12105	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
XFUD_RS12110	COG2154	pterin-4-alpha-carbinolamine dehydratase
XFUD_RS12120	COG0564	pseudouridine synthase activity
XFUD_RS12125	COG1530	ribonuclease E activity
XFUD_RS12130	COG2197	response regulator
XFUD_RS12135	COG1054	Belongs to the UPF0176 family
XFUD_RS12150	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
XFUD_RS12165	COG0488	(ABC) transporter
XFUD_RS12175	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
XFUD_RS12180	COG1278	Cold shock
XFUD_RS12190	COG0501	Belongs to the peptidase M48B family
XFUD_RS12200	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
XFUD_RS12205	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
XFUD_RS12210	COG0049	tRNA binding
XFUD_RS12220	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
XFUD_RS12225	COG0085	RNA polymerase activity
XFUD_RS12230	COG0222	ribosome binding
XFUD_RS12235	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
XFUD_RS12240	COG0081	regulation of translation
XFUD_RS12245	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
XFUD_RS12250	COG0250	Participates in transcription elongation, termination and antitermination
XFUD_RS12255	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
XFUD_RS12265	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
XFUD_RS12285	COG0012	GTP binding
XFUD_RS12290	COG0193	aminoacyl-tRNA hydrolase activity
XFUD_RS12295	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
XFUD_RS12300	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
XFUD_RS12310	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
XFUD_RS12315	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
XFUD_RS12325	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
XFUD_RS12330	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
XFUD_RS12340	COG0116	Belongs to the methyltransferase superfamily
XFUD_RS12340	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
XFUD_RS12395	COG2095	MarC family integral membrane protein
XFUD_RS12405	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
XFUD_RS12420	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
XFUD_RS12435	COG2132	Multicopper oxidase
XFUD_RS12445	COG0210	DNA helicase
XFUD_RS12450	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
XFUD_RS12455	COG0616	signal peptide processing
XFUD_RS12460	COG0534	Mate efflux family protein
XFUD_RS12480	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
XFUD_RS12490	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
XFUD_RS12495	COG2201	protein-glutamate methylesterase activity
XFUD_RS12500	COG2177	Part of the ABC transporter FtsEX involved in
XFUD_RS12505	COG2884	Cell division ATP-binding protein ftsE
XFUD_RS12510	COG0513	Belongs to the DEAD box helicase family
XFUD_RS12515	COG3118	belongs to the thioredoxin family
XFUD_RS12520	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
XFUD_RS12535	COG0793	Belongs to the peptidase S41A family
XFUD_RS12540	COG4942	peptidase
XFUD_RS12555	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XFUD_RS12560	COG0493	'glutamate synthase
XFUD_RS12565	COG0067	glutamate synthase
XFUD_RS12565	COG0069	glutamate synthase activity
XFUD_RS12565	COG0070	glutamate synthase
XFUD_RS12600	COG1028	Short-chain dehydrogenase reductase Sdr
XFUD_RS12625	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
XFUD_RS12665	COG1280	lysine exporter protein (LysE YggA)
XFUD_RS12680	COG4942	peptidase
XFUD_RS12710	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
XFUD_RS12725	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
XFUD_RS12840	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
XFUD_RS12845	COG3657	addiction module killer protein
XFUD_RS12915	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
XFUD_RS12930	COG0594	ribonuclease P activity
XFUD_RS12950	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
XFUD_RS12970	COG3451	type IV secretory pathway VirB4
XFUD_RS13000	COG3736	Type IV secretory pathway, component VirB8
XFUD_RS13010	COG2948	multi-organism process
XFUD_RS13045	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
XFUD_RS13110	COG0596	Alpha beta hydrolase
XFUD_RS13175	COG3657	addiction module killer protein
XFUD_RS13250	COG1475	DNA binding
XFUD_RS13260	COG0629	single-stranded DNA binding