locus-tag	class	description
IUD22_RS00010	COG0592	DNA-directed DNA polymerase activity
IUD22_RS00020	COG0187	DNA topoisomerase II activity
IUD22_RS00030	COG0501	Belongs to the peptidase M48B family
IUD22_RS00060	COG0823	Involved in the tonB-independent uptake of proteins
IUD22_RS00060	COG1506	peptidase
IUD22_RS00060	COG4946	Tricorn protease homolog
IUD22_RS00090	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IUD22_RS00150	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
IUD22_RS00160	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
IUD22_RS00170	COG0511	ligase activity, forming carbon-carbon bonds
IUD22_RS00175	COG0439	Biotin carboxylase
IUD22_RS00180	COG0210	DNA helicase
IUD22_RS00210	COG1040	competence protein
IUD22_RS00220	COG1752	Esterase of the alpha-beta hydrolase superfamily
IUD22_RS00260	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IUD22_RS00270	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IUD22_RS00295	COG3121	Chaperone
IUD22_RS00300	COG3539	Fimbrial protein
IUD22_RS00310	COG1546	Belongs to the CinA family
IUD22_RS00315	COG0477	Major facilitator Superfamily
IUD22_RS00320	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IUD22_RS00335	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IUD22_RS00340	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IUD22_RS00350	COG1534	Rna-binding protein
IUD22_RS00380	COG1560	Kdo2-lipid A biosynthetic process
IUD22_RS00385	COG1519	Transferase
IUD22_RS00425	COG1393	Belongs to the ArsC family
IUD22_RS00435	COG0367	asparagine synthase
IUD22_RS00445	COG2070	2-Nitropropane dioxygenase
IUD22_RS00475	COG0339	signal peptide processing
IUD22_RS00490	COG2132	Multicopper oxidase
IUD22_RS00520	COG0795	lipopolysaccharide-transporting ATPase activity
IUD22_RS00555	COG4221	oxidoreductase activity
IUD22_RS00575	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IUD22_RS00595	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IUD22_RS00645	COG2223	nitrite transmembrane transporter activity
IUD22_RS00655	COG0739	heme binding
IUD22_RS00690	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IUD22_RS00705	COG1028	Short-chain dehydrogenase reductase Sdr
IUD22_RS00715	COG1272	protein, Hemolysin III
IUD22_RS00720	COG0463	Glycosyl transferase, family 2
IUD22_RS00725	COG0084	hydrolase, TatD family'
IUD22_RS00755	COG0330	HflC and HflK could
IUD22_RS00760	COG3956	TIGRFAM MazG family protein
IUD22_RS00765	COG1218	3'(2'),5'-bisphosphate nucleotidase
IUD22_RS00770	COG0494	nUDIX hydrolase
IUD22_RS00780	COG1385	rRNA (uridine-N3-)-methyltransferase activity
IUD22_RS00785	COG0513	Belongs to the DEAD box helicase family
IUD22_RS00790	COG0720	synthase
IUD22_RS00815	COG1981	membrane
IUD22_RS00850	COG0512	Glutamine amidotransferase of anthranilate synthase
IUD22_RS00885	COG0006	proline dipeptidase activity
IUD22_RS00905	COG1862	Preprotein translocase
IUD22_RS00910	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IUD22_RS00915	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IUD22_RS00925	COG0617	tRNA 3'-terminal CCA addition
IUD22_RS00965	COG0195	Participates in both transcription termination and antitermination
IUD22_RS00995	COG1733	regulation of RNA biosynthetic process
IUD22_RS01000	COG0702	epimerase
IUD22_RS01045	COG2086	electron transfer activity
IUD22_RS01075	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IUD22_RS01105	COG0477	Major facilitator Superfamily
IUD22_RS01125	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IUD22_RS01130	COG0671	phosphoesterase, PA-phosphatase related
IUD22_RS01145	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IUD22_RS01150	COG0628	permease
IUD22_RS01170	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IUD22_RS01175	COG1090	epimerase
IUD22_RS01180	COG0318	PFAM AMP-dependent synthetase and ligase
IUD22_RS01200	COG1049	propionate catabolic process, 2-methylcitrate cycle
IUD22_RS01245	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IUD22_RS01270	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IUD22_RS01290	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
IUD22_RS01295	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
IUD22_RS01300	COG1034	ATP synthesis coupled electron transport
IUD22_RS01335	COG1007	ATP synthesis coupled electron transport
IUD22_RS01340	COG1028	Short-chain dehydrogenase reductase Sdr
IUD22_RS01345	COG2851	Citrate transporter
IUD22_RS01360	COG0642	Histidine kinase
IUD22_RS01375	COG2205	protein histidine kinase activity
IUD22_RS01375	COG0784	Response regulator, receiver
IUD22_RS01395	COG0280	phosphate acetyltransferase
IUD22_RS01395	COG0281	malic enzyme
IUD22_RS01405	COG0742	ribosomal rna small subunit methyltransferase
IUD22_RS01425	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
IUD22_RS01445	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IUD22_RS01470	COG2166	iron-sulfur cluster assembly
IUD22_RS01500	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IUD22_RS01575	COG1321	iron dependent repressor
IUD22_RS01595	COG1946	Acyl-CoA thioesterase
IUD22_RS01680	COG0575	Belongs to the CDS family
IUD22_RS01775	COG0354	folic acid binding
IUD22_RS01785	COG2009	succinate dehydrogenase
IUD22_RS01790	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
IUD22_RS01800	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IUD22_RS01830	COG0811	peptide transport
IUD22_RS01880	COG3093	addiction module antidote protein HigA
IUD22_RS01890	COG2944	sequence-specific DNA binding
IUD22_RS01955	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
IUD22_RS01975	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IUD22_RS02045	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IUD22_RS02070	COG1024	Enoyl-CoA hydratase
IUD22_RS02075	COG0019	diaminopimelate decarboxylase activity
IUD22_RS02095	COG0494	nUDIX hydrolase
IUD22_RS02100	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
IUD22_RS02125	COG0312	modulator of DNA gyrase
IUD22_RS02135	COG0312	modulator of DNA gyrase
IUD22_RS02140	COG0583	DNA-binding transcription factor activity
IUD22_RS02155	COG1064	alcohol dehydrogenase
IUD22_RS02210	COG0356	it plays a direct role in the translocation of protons across the membrane
IUD22_RS02330	COG0201	protein transport
IUD22_RS02360	COG2960	long-chain fatty acid transporting porin activity
IUD22_RS02365	COG0606	chelatase, subunit chli
IUD22_RS02390	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
IUD22_RS02450	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IUD22_RS02455	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IUD22_RS02470	COG1187	pseudouridine synthase activity
IUD22_RS02475	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IUD22_RS02495	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IUD22_RS02500	COG0625	glutathione transferase activity
IUD22_RS02510	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IUD22_RS02515	COG1217	gtp-binding protein TYPA
IUD22_RS02550	COG0842	Transport permease protein
IUD22_RS02555	COG1131	(ABC) transporter
IUD22_RS02575	COG1643	Atp-dependent helicase
IUD22_RS02585	COG1956	GAF domain-containing protein
IUD22_RS02590	COG0729	surface antigen
IUD22_RS02595	COG2911	Protein conserved in bacteria
IUD22_RS02605	COG0582	viral genome integration into host DNA
IUD22_RS02775	COG0668	transmembrane transport
IUD22_RS02805	COG5297	Belongs to the glycosyl hydrolase family 6
IUD22_RS02840	COG2733	membrane
IUD22_RS02845	COG1253	flavin adenine dinucleotide binding
IUD22_RS02910	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
IUD22_RS02910	COG0644	oxidoreductase
IUD22_RS02925	COG3218	ABC-type transport auxiliary lipoprotein component
IUD22_RS02925	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IUD22_RS02930	COG1127	ABC transporter
IUD22_RS02935	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IUD22_RS02970	COG1077	Cell shape determining protein MreB Mrl
IUD22_RS02975	COG1792	Involved in formation and maintenance of cell shape
IUD22_RS02980	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
IUD22_RS02985	COG0768	penicillin binding
IUD22_RS02990	COG0772	Belongs to the SEDS family
IUD22_RS03000	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IUD22_RS03020	COG2894	cell division
IUD22_RS03040	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
IUD22_RS03055	COG2353	YceI-like domain
IUD22_RS03125	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
IUD22_RS03130	COG4208	sulfate ABC transporter
IUD22_RS03155	COG1846	Transcriptional regulator
IUD22_RS03195	COG0741	lytic transglycosylase activity
IUD22_RS03205	COG1999	signal sequence binding
IUD22_RS03230	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IUD22_RS03265	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IUD22_RS03275	COG0514	ATP-dependent DNA helicase (RecQ)
IUD22_RS03280	COG0783	Belongs to the Dps family
IUD22_RS03285	COG1643	Atp-dependent helicase
IUD22_RS03295	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
IUD22_RS03300	COG1845	cytochrome c oxidase, subunit III
IUD22_RS03305	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IUD22_RS03310	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IUD22_RS03315	COG0142	geranyltranstransferase activity
IUD22_RS03330	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IUD22_RS03350	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IUD22_RS03385	COG1137	ATPase activity
IUD22_RS03400	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
IUD22_RS03410	COG0271	Belongs to the BolA IbaG family
IUD22_RS03450	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IUD22_RS03460	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IUD22_RS03495	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IUD22_RS03525	COG0542	response to heat
IUD22_RS03545	COG0492	ferredoxin-NADP+ reductase activity
IUD22_RS03565	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IUD22_RS03575	COG4191	Histidine kinase
IUD22_RS03580	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IUD22_RS03585	COG1028	Short-chain dehydrogenase reductase Sdr
IUD22_RS03615	COG1609	Transcriptional regulator
IUD22_RS03620	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IUD22_RS03625	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
IUD22_RS03630	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
IUD22_RS03640	COG0726	polysaccharide deacetylase
IUD22_RS03645	COG0297	glycogen (starch) synthase activity
IUD22_RS03665	COG0719	Fe-S assembly protein
IUD22_RS03670	COG0396	ATPase activity
IUD22_RS03675	COG0719	Fe-S assembly protein
IUD22_RS03680	COG1959	2 iron, 2 sulfur cluster binding
IUD22_RS03735	COG0308	aminopeptidase N
IUD22_RS03785	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
IUD22_RS03810	COG1561	YicC-like family, N-terminal region
IUD22_RS03825	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IUD22_RS03860	COG5295	Hep Hag repeat protein
IUD22_RS03865	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IUD22_RS03870	COG1459	type II secretion system
IUD22_RS03875	COG2165	general secretion pathway protein
IUD22_RS03880	COG4970	Tfp pilus assembly protein FimT
IUD22_RS03885	COG2165	general secretion pathway protein
IUD22_RS03890	COG4795	General secretion pathway protein
IUD22_RS03895	COG3156	type II secretion system protein K
IUD22_RS03900	COG3166	PFAM Fimbrial assembly family protein
IUD22_RS03915	COG1450	Type ii and iii secretion system protein
IUD22_RS03930	COG3634	alkyl hydroperoxide reductase activity
IUD22_RS03935	COG0583	DNA-binding transcription factor activity
IUD22_RS03995	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
IUD22_RS04020	COG0567	Dehydrogenase, E1 component
IUD22_RS04025	COG2850	peptidyl-arginine hydroxylation
IUD22_RS04040	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
IUD22_RS04140	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IUD22_RS04145	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IUD22_RS04150	COG2902	Dehydrogenase
IUD22_RS04190	COG2925	Exonuclease
IUD22_RS04200	COG0025	NhaP-type Na H and K H
IUD22_RS04220	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IUD22_RS04245	COG0006	proline dipeptidase activity
IUD22_RS04255	COG0778	Nitroreductase
IUD22_RS04290	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IUD22_RS04330	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IUD22_RS04340	COG0557	exoribonuclease II activity
IUD22_RS04350	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IUD22_RS04365	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
IUD22_RS04370	COG1289	transmembrane transporter activity
IUD22_RS04390	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
IUD22_RS04400	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IUD22_RS04415	COG0596	Alpha beta hydrolase
IUD22_RS04420	COG0727	PFAM Uncharacterised protein family (UPF0153)
IUD22_RS04465	COG0840	transmembrane signaling receptor activity
IUD22_RS04470	COG0784	Response regulator, receiver
IUD22_RS04470	COG0643	Histidine kinase
IUD22_RS04470	COG2198	Histidine kinase
IUD22_RS04500	COG0285	dihydrofolate synthase activity
IUD22_RS04510	COG0339	signal peptide processing
IUD22_RS04530	COG1301	dicarboxylic acid transport
IUD22_RS04535	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IUD22_RS04545	COG2091	lysine biosynthetic process via aminoadipic acid
IUD22_RS04590	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IUD22_RS04620	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IUD22_RS04620	COG0512	Glutamine amidotransferase of anthranilate synthase
IUD22_RS04640	COG0084	hydrolase, TatD family'
IUD22_RS04660	COG0552	protein localization to endoplasmic reticulum
IUD22_RS04755	COG0824	Thioesterase
IUD22_RS04780	COG2885	chlorophyll binding
IUD22_RS04790	COG0602	queuosine metabolic process
IUD22_RS04810	COG0386	Belongs to the glutathione peroxidase family
IUD22_RS04830	COG0406	alpha-ribazole phosphatase activity
IUD22_RS04995	COG0675	Transposase, IS605 OrfB family
IUD22_RS05155	COG2369	cell adhesion
IUD22_RS05205	COG0582	viral genome integration into host DNA
IUD22_RS05210	COG3567	Phage-associated protein, HI1409 family
IUD22_RS05215	COG5410	chromosome segregation
IUD22_RS05240	COG3772	lysozyme
IUD22_RS05275	COG3617	BRO family, N-terminal domain
IUD22_RS05360	COG5532	Uncharacterized conserved protein (DUF2303)
IUD22_RS05390	COG0629	single-stranded DNA binding
IUD22_RS05400	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
IUD22_RS05405	COG3852	Histidine kinase
IUD22_RS05410	COG2204	response regulator
IUD22_RS05425	COG0004	ammonium transporteR
IUD22_RS05430	COG0347	Belongs to the P(II) protein family
IUD22_RS05435	COG0174	glutamine synthetase
IUD22_RS05445	COG2353	YceI-like domain
IUD22_RS05500	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
IUD22_RS05505	COG1764	response to oxidative stress
IUD22_RS05510	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IUD22_RS05555	COG1399	metal-binding, possibly nucleic acid-binding protein
IUD22_RS05565	COG0714	Associated with various cellular activities
IUD22_RS05585	COG0537	adenosine 5'-monophosphoramidase activity
IUD22_RS05600	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
IUD22_RS05640	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IUD22_RS05665	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
IUD22_RS05665	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
IUD22_RS05715	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
IUD22_RS05730	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
IUD22_RS05745	COG0251	oxidation-reduction process
IUD22_RS05810	COG3077	Addiction module antitoxin, RelB DinJ family
IUD22_RS05815	COG3041	Addiction module toxin RelE StbE family
IUD22_RS05885	COG3772	lysozyme
IUD22_RS05950	COG4197	protein conserved in bacteria, prophage-related
IUD22_RS06055	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
IUD22_RS06060	COG0392	lysyltransferase activity
IUD22_RS06060	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
IUD22_RS06070	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IUD22_RS06080	COG0463	Glycosyl transferase, family 2
IUD22_RS06125	COG3275	phosphorelay sensor kinase activity
IUD22_RS06130	COG0400	carboxylic ester hydrolase activity
IUD22_RS06150	COG2226	methyltransferase
IUD22_RS06175	COG2027	D-alanyl-D-alanine carboxypeptidase
IUD22_RS06185	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IUD22_RS06215	COG0386	Belongs to the glutathione peroxidase family
IUD22_RS06220	COG1131	(ABC) transporter
IUD22_RS06250	COG3657	addiction module killer protein
IUD22_RS06255	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IUD22_RS06360	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
IUD22_RS06365	COG0488	(ABC) transporter
IUD22_RS06375	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
IUD22_RS06385	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IUD22_RS06385	COG4651	solute:proton antiporter activity
IUD22_RS06445	COG0859	PFAM glycosyl transferase family 9
IUD22_RS06460	COG0631	protein serine/threonine phosphatase activity
IUD22_RS06465	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IUD22_RS06500	COG2183	response to ionizing radiation
IUD22_RS06515	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
IUD22_RS06520	COG3118	belongs to the thioredoxin family
IUD22_RS06565	COG2951	lytic endotransglycosylase activity
IUD22_RS06570	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IUD22_RS06685	COG0277	FAD linked oxidase domain protein
IUD22_RS06690	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IUD22_RS06695	COG0531	amino acid
IUD22_RS06785	COG0460	homoserine dehydrogenase
IUD22_RS06785	COG0527	aspartate kinase activity
IUD22_RS06805	COG1686	Belongs to the peptidase S11 family
IUD22_RS06830	COG4953	penicillin-binding protein 1C
IUD22_RS06855	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IUD22_RS06920	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IUD22_RS06925	COG1506	peptidase
IUD22_RS06925	COG0823	Involved in the tonB-independent uptake of proteins
IUD22_RS06930	COG1297	OPT oligopeptide transporter protein
IUD22_RS06960	COG0676	glucose-6-phosphate 1-epimerase activity
IUD22_RS06970	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IUD22_RS06975	COG1335	isochorismatase
IUD22_RS06980	COG0318	PFAM AMP-dependent synthetase and ligase
IUD22_RS06990	COG0463	Glycosyl transferase, family 2
IUD22_RS07005	COG1192	Involved in chromosome partitioning
IUD22_RS07065	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IUD22_RS07110	COG0489	protein tyrosine kinase activity
IUD22_RS07120	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IUD22_RS07215	COG1605	Chorismate mutase
IUD22_RS07215	COG0077	Prephenate dehydratase
IUD22_RS07230	COG1668	transmembrane transport
IUD22_RS07235	COG4555	ABC transporter
IUD22_RS07260	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
IUD22_RS07270	COG0287	Prephenate dehydrogenase
IUD22_RS07270	COG1605	Chorismate mutase
IUD22_RS07305	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IUD22_RS07330	COG1278	Cold shock
IUD22_RS07340	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
IUD22_RS07350	COG2954	triphosphatase activity
IUD22_RS07365	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
IUD22_RS07370	COG0438	transferase activity, transferring glycosyl groups
IUD22_RS07380	COG0438	transferase activity, transferring glycosyl groups
IUD22_RS07445	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IUD22_RS07450	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IUD22_RS07465	COG1064	alcohol dehydrogenase
IUD22_RS07480	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
IUD22_RS07490	COG0436	Aminotransferase
IUD22_RS07570	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
IUD22_RS07570	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IUD22_RS07620	COG0196	riboflavin kinase activity
IUD22_RS07625	COG0728	peptidoglycan biosynthetic process
IUD22_RS07630	COG0268	Binds directly to 16S ribosomal RNA
IUD22_RS07680	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IUD22_RS07695	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
IUD22_RS07750	COG0395	ABC-type sugar transport system, permease component
IUD22_RS07755	COG1175	transmembrane transport
IUD22_RS07785	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
IUD22_RS07805	COG0436	Aminotransferase
IUD22_RS07865	COG5434	Belongs to the glycosyl hydrolase 28 family
IUD22_RS07890	COG0402	S-adenosylhomocysteine deaminase activity
IUD22_RS07900	COG1509	lysine 2,3-aminomutase activity
IUD22_RS07935	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IUD22_RS07940	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IUD22_RS07955	COG1028	Short-chain dehydrogenase reductase Sdr
IUD22_RS08005	COG0142	geranyltranstransferase activity
IUD22_RS08030	COG1301	dicarboxylic acid transport
IUD22_RS08040	COG0791	NLP P60 protein
IUD22_RS08045	COG0791	NLP P60 protein
IUD22_RS08055	COG2311	Membrane
IUD22_RS08065	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IUD22_RS08120	COG0351	phosphomethylpyrimidine kinase
IUD22_RS08120	COG0352	thiamine-phosphate diphosphorylase activity
IUD22_RS08130	COG1324	tolerance protein
IUD22_RS08165	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IUD22_RS08170	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IUD22_RS08175	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
IUD22_RS08190	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IUD22_RS08210	COG4774	siderophore transport
IUD22_RS08235	COG1477	protein flavinylation
IUD22_RS08240	COG1555	photosystem II stabilization
IUD22_RS08245	COG3178	'Phosphotransferase
IUD22_RS08250	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IUD22_RS08260	COG0628	permease
IUD22_RS08275	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IUD22_RS08300	COG3590	peptidase
IUD22_RS08350	COG0805	protein transport
IUD22_RS08360	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IUD22_RS08360	COG0519	Catalyzes the synthesis of GMP from XMP
IUD22_RS08370	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
IUD22_RS08385	COG3107	peptidoglycan biosynthetic process
IUD22_RS08410	COG2878	Part of a membrane complex involved in electron transport
IUD22_RS08485	COG0629	single-stranded DNA binding
IUD22_RS08510	COG0827	DNA restriction-modification system
IUD22_RS08515	COG0827	DNA restriction-modification system
IUD22_RS08555	COG4968	Prepilin-type N-terminal cleavage methylation domain
IUD22_RS08560	COG1611	Belongs to the LOG family
IUD22_RS08565	COG4943	cyclic-guanylate-specific phosphodiesterase activity
IUD22_RS08570	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IUD22_RS08580	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IUD22_RS08610	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IUD22_RS08625	COG0330	HflC and HflK could
IUD22_RS08630	COG0330	HflC and HflK could
IUD22_RS08635	COG0604	alcohol dehydrogenase
IUD22_RS08665	COG1183	phosphatidylcholine synthase activity
IUD22_RS08685	COG0668	transmembrane transport
IUD22_RS08690	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IUD22_RS08705	COG1610	YqeY-like protein
IUD22_RS08715	COG0358	DNA primase activity
IUD22_RS08755	COG1074	ATP-dependent DNA helicase activity
IUD22_RS08760	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
IUD22_RS08765	COG1127	ABC transporter
IUD22_RS08770	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IUD22_RS08790	COG2853	Lipoprotein
IUD22_RS08800	COG1116	anion transmembrane transporter activity
IUD22_RS08810	COG0531	amino acid
IUD22_RS08815	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IUD22_RS08820	COG0861	Integral membrane protein TerC family
IUD22_RS08855	COG2193	ferroxidase activity
IUD22_RS08945	COG2194	sulfuric ester hydrolase activity
IUD22_RS08985	COG0667	Aldo Keto reductase
IUD22_RS08990	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IUD22_RS09000	COG0305	Participates in initiation and elongation during chromosome replication
IUD22_RS09030	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IUD22_RS09040	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IUD22_RS09045	COG0277	FAD linked oxidase domain protein
IUD22_RS09060	COG4206	TonB-dependent receptor
IUD22_RS09160	COG3617	BRO family, N-terminal domain
IUD22_RS09230	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IUD22_RS09250	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
IUD22_RS09275	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IUD22_RS09275	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IUD22_RS09295	COG0488	(ABC) transporter
IUD22_RS09305	COG3011	Protein conserved in bacteria
IUD22_RS09340	COG1918	ferrous iron import across plasma membrane
IUD22_RS09340	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
IUD22_RS09350	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
IUD22_RS09375	COG0758	DNA mediated transformation
IUD22_RS09420	COG2969	positive regulation of protein catabolic process
IUD22_RS09425	COG0625	glutathione transferase activity
IUD22_RS09430	COG2857	Cytochrome c1
IUD22_RS09435	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
IUD22_RS09440	COG0723	plastoquinol--plastocyanin reductase activity
IUD22_RS09445	COG0741	lytic transglycosylase activity
IUD22_RS09455	COG1702	phosphate starvation-inducible protein PhoH
IUD22_RS09470	COG4535	Mg2 and Co2 transporter CorC
IUD22_RS09480	COG0598	Magnesium transport protein CorA
IUD22_RS09540	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IUD22_RS09550	COG1199	ATP-dependent helicase activity
IUD22_RS09560	COG0288	reversible hydration of carbon dioxide
IUD22_RS09585	COG2011	ABC-type metal ion transport system permease component
IUD22_RS09605	COG0508	dehydrogenase complex catalyzes the overall conversion of
IUD22_RS09610	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IUD22_RS09625	COG0626	cystathionine gamma-synthase activity
IUD22_RS09630	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IUD22_RS09635	COG0739	heme binding
IUD22_RS09655	COG1238	metal cluster binding
IUD22_RS09675	COG5002	protein histidine kinase activity
IUD22_RS09695	COG3858	chitin binding
IUD22_RS09695	COG1388	LysM domain
IUD22_RS09700	COG3525	Glycosyl hydrolase, family 20, catalytic domain
IUD22_RS09710	COG1472	Belongs to the glycosyl hydrolase 3 family
IUD22_RS09725	COG3537	Alpha-1,2-mannosidase
IUD22_RS09750	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IUD22_RS09755	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IUD22_RS09800	COG0469	pyruvate kinase activity
IUD22_RS09820	COG0735	belongs to the Fur family
IUD22_RS09830	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IUD22_RS09830	COG5297	Belongs to the glycosyl hydrolase family 6
IUD22_RS09860	COG4305	rare lipoprotein A
IUD22_RS09870	COG0739	heme binding
IUD22_RS09885	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
IUD22_RS09895	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
IUD22_RS09925	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IUD22_RS09940	COG3116	cell division
IUD22_RS09955	COG0471	metal ion transport
IUD22_RS09955	COG3273	potassium ion transport
IUD22_RS10010	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IUD22_RS10070	COG0860	N-Acetylmuramoyl-L-alanine amidase
IUD22_RS10075	COG0802	atpase or kinase
IUD22_RS10080	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
IUD22_RS10080	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IUD22_RS10180	COG0745	RESPONSE REGULATOR receiver
IUD22_RS10185	COG0642	Histidine kinase
IUD22_RS10195	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
IUD22_RS10240	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
IUD22_RS10250	COG2831	hemolysin activation secretion protein
IUD22_RS10275	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
IUD22_RS10315	COG0316	Belongs to the HesB IscA family
IUD22_RS10355	COG0697	spore germination
IUD22_RS10360	COG0671	phosphoesterase, PA-phosphatase related
IUD22_RS10375	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
IUD22_RS10395	COG1132	(ABC) transporter
IUD22_RS10400	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IUD22_RS10405	COG1538	Outer membrane efflux protein
IUD22_RS10430	COG0745	RESPONSE REGULATOR receiver
IUD22_RS10435	COG4783	chaperone-mediated protein folding
IUD22_RS10445	COG0473	3-isopropylmalate dehydrogenase activity
IUD22_RS10455	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IUD22_RS10460	COG3083	sulfuric ester hydrolase activity
IUD22_RS10465	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
IUD22_RS10490	COG0564	pseudouridine synthase activity
IUD22_RS10495	COG1530	ribonuclease E activity
IUD22_RS10500	COG2197	response regulator
IUD22_RS10515	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IUD22_RS10530	COG0488	(ABC) transporter
IUD22_RS10545	COG1278	Cold shock
IUD22_RS10645	COG0012	GTP binding
IUD22_RS10735	COG2095	MarC family integral membrane protein
IUD22_RS10745	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
IUD22_RS10770	COG2132	Multicopper oxidase
IUD22_RS10780	COG0210	DNA helicase
IUD22_RS10790	COG0616	signal peptide processing
IUD22_RS10810	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IUD22_RS10830	COG2201	protein-glutamate methylesterase activity
IUD22_RS10835	COG2177	Part of the ABC transporter FtsEX involved in
IUD22_RS10840	COG2884	Cell division ATP-binding protein ftsE
IUD22_RS10850	COG3118	belongs to the thioredoxin family
IUD22_RS10855	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
IUD22_RS10870	COG0793	Belongs to the peptidase S41A family
IUD22_RS10875	COG4942	peptidase
IUD22_RS10890	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IUD22_RS10895	COG0493	'glutamate synthase
IUD22_RS10900	COG0067	glutamate synthase
IUD22_RS10900	COG0069	glutamate synthase activity
IUD22_RS10900	COG0070	glutamate synthase
IUD22_RS10950	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
IUD22_RS11000	COG4942	peptidase
IUD22_RS11145	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IUD22_RS11150	COG3657	addiction module killer protein
IUD22_RS11220	COG3210	domain, Protein
IUD22_RS11255	COG3451	type IV secretory pathway VirB4
IUD22_RS11310	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
IUD22_RS11415	COG0675	Transposase, IS605 OrfB family
IUD22_RS11435	COG0629	single-stranded DNA binding
IUD22_RS11445	COG4962	Type ii secretion system protein e