locus-tag	class	description
IUD25_RS00010	COG0592	DNA-directed DNA polymerase activity
IUD25_RS00020	COG0187	DNA topoisomerase II activity
IUD25_RS00030	COG0501	Belongs to the peptidase M48B family
IUD25_RS00060	COG4946	Tricorn protease homolog
IUD25_RS00060	COG1506	peptidase
IUD25_RS00060	COG0823	Involved in the tonB-independent uptake of proteins
IUD25_RS00090	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IUD25_RS00150	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
IUD25_RS00160	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
IUD25_RS00170	COG0511	ligase activity, forming carbon-carbon bonds
IUD25_RS00175	COG0439	Biotin carboxylase
IUD25_RS00180	COG0210	DNA helicase
IUD25_RS00210	COG1040	competence protein
IUD25_RS00220	COG1752	Esterase of the alpha-beta hydrolase superfamily
IUD25_RS00260	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IUD25_RS00270	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IUD25_RS00295	COG3121	Chaperone
IUD25_RS00300	COG3539	Fimbrial protein
IUD25_RS00310	COG1546	Belongs to the CinA family
IUD25_RS00315	COG0477	Major facilitator Superfamily
IUD25_RS00320	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IUD25_RS00335	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IUD25_RS00340	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IUD25_RS00350	COG1534	Rna-binding protein
IUD25_RS00380	COG1560	Kdo2-lipid A biosynthetic process
IUD25_RS00385	COG1519	Transferase
IUD25_RS00425	COG1393	Belongs to the ArsC family
IUD25_RS00435	COG0367	asparagine synthase
IUD25_RS00445	COG2070	2-Nitropropane dioxygenase
IUD25_RS00475	COG0339	signal peptide processing
IUD25_RS00490	COG2132	Multicopper oxidase
IUD25_RS00520	COG0795	lipopolysaccharide-transporting ATPase activity
IUD25_RS00555	COG4221	oxidoreductase activity
IUD25_RS00575	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IUD25_RS00585	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IUD25_RS00625	COG2223	nitrite transmembrane transporter activity
IUD25_RS00635	COG0739	heme binding
IUD25_RS00685	COG1028	Short-chain dehydrogenase reductase Sdr
IUD25_RS00695	COG1272	protein, Hemolysin III
IUD25_RS00700	COG0463	Glycosyl transferase, family 2
IUD25_RS00705	COG0084	hydrolase, TatD family'
IUD25_RS00735	COG0330	HflC and HflK could
IUD25_RS00740	COG3956	TIGRFAM MazG family protein
IUD25_RS00745	COG1218	3'(2'),5'-bisphosphate nucleotidase
IUD25_RS00750	COG0494	nUDIX hydrolase
IUD25_RS00760	COG1385	rRNA (uridine-N3-)-methyltransferase activity
IUD25_RS00765	COG0513	Belongs to the DEAD box helicase family
IUD25_RS00770	COG0720	synthase
IUD25_RS00795	COG1981	membrane
IUD25_RS00830	COG0512	Glutamine amidotransferase of anthranilate synthase
IUD25_RS00865	COG0006	proline dipeptidase activity
IUD25_RS00885	COG1862	Preprotein translocase
IUD25_RS00890	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IUD25_RS00895	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IUD25_RS00905	COG0617	tRNA 3'-terminal CCA addition
IUD25_RS00945	COG0195	Participates in both transcription termination and antitermination
IUD25_RS00975	COG1733	regulation of RNA biosynthetic process
IUD25_RS00980	COG0702	epimerase
IUD25_RS01025	COG2086	electron transfer activity
IUD25_RS01055	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IUD25_RS01080	COG0477	Major facilitator Superfamily
IUD25_RS01100	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IUD25_RS01105	COG0671	phosphoesterase, PA-phosphatase related
IUD25_RS01120	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IUD25_RS01125	COG0628	permease
IUD25_RS01145	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IUD25_RS01150	COG1090	epimerase
IUD25_RS01155	COG0318	PFAM AMP-dependent synthetase and ligase
IUD25_RS01175	COG1049	propionate catabolic process, 2-methylcitrate cycle
IUD25_RS01220	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IUD25_RS01245	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IUD25_RS01265	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
IUD25_RS01270	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
IUD25_RS01275	COG1034	ATP synthesis coupled electron transport
IUD25_RS01310	COG1007	ATP synthesis coupled electron transport
IUD25_RS01315	COG1028	Short-chain dehydrogenase reductase Sdr
IUD25_RS01320	COG2851	Citrate transporter
IUD25_RS01335	COG0642	Histidine kinase
IUD25_RS01350	COG0784	Response regulator, receiver
IUD25_RS01350	COG2205	protein histidine kinase activity
IUD25_RS01370	COG0280	phosphate acetyltransferase
IUD25_RS01370	COG0281	malic enzyme
IUD25_RS01380	COG0742	ribosomal rna small subunit methyltransferase
IUD25_RS01400	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
IUD25_RS01420	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IUD25_RS01445	COG2166	iron-sulfur cluster assembly
IUD25_RS01475	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IUD25_RS01550	COG1321	iron dependent repressor
IUD25_RS01570	COG1946	Acyl-CoA thioesterase
IUD25_RS01660	COG0575	Belongs to the CDS family
IUD25_RS01755	COG0354	folic acid binding
IUD25_RS01765	COG2009	succinate dehydrogenase
IUD25_RS01770	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
IUD25_RS01780	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IUD25_RS01810	COG0811	peptide transport
IUD25_RS01860	COG3093	addiction module antidote protein HigA
IUD25_RS01870	COG2944	sequence-specific DNA binding
IUD25_RS01935	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
IUD25_RS01955	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IUD25_RS02025	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IUD25_RS02050	COG1024	Enoyl-CoA hydratase
IUD25_RS02055	COG0019	diaminopimelate decarboxylase activity
IUD25_RS02075	COG0494	nUDIX hydrolase
IUD25_RS02080	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
IUD25_RS02105	COG0312	modulator of DNA gyrase
IUD25_RS02115	COG0312	modulator of DNA gyrase
IUD25_RS02120	COG0583	DNA-binding transcription factor activity
IUD25_RS02135	COG1064	alcohol dehydrogenase
IUD25_RS02190	COG0356	it plays a direct role in the translocation of protons across the membrane
IUD25_RS02310	COG0201	protein transport
IUD25_RS02340	COG2960	long-chain fatty acid transporting porin activity
IUD25_RS02345	COG0606	chelatase, subunit chli
IUD25_RS02370	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
IUD25_RS02430	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IUD25_RS02435	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IUD25_RS02450	COG1187	pseudouridine synthase activity
IUD25_RS02455	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IUD25_RS02475	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IUD25_RS02480	COG0625	glutathione transferase activity
IUD25_RS02490	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IUD25_RS02495	COG1217	gtp-binding protein TYPA
IUD25_RS02535	COG0842	Transport permease protein
IUD25_RS02540	COG1131	(ABC) transporter
IUD25_RS02560	COG1643	Atp-dependent helicase
IUD25_RS02570	COG1956	GAF domain-containing protein
IUD25_RS02575	COG0729	surface antigen
IUD25_RS02580	COG2911	Protein conserved in bacteria
IUD25_RS02590	COG0582	viral genome integration into host DNA
IUD25_RS02755	COG0668	transmembrane transport
IUD25_RS02785	COG5297	Belongs to the glycosyl hydrolase family 6
IUD25_RS02820	COG2733	membrane
IUD25_RS02825	COG1253	flavin adenine dinucleotide binding
IUD25_RS02890	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
IUD25_RS02890	COG0644	oxidoreductase
IUD25_RS02905	COG3218	ABC-type transport auxiliary lipoprotein component
IUD25_RS02905	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IUD25_RS02910	COG1127	ABC transporter
IUD25_RS02915	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IUD25_RS02950	COG1077	Cell shape determining protein MreB Mrl
IUD25_RS02955	COG1792	Involved in formation and maintenance of cell shape
IUD25_RS02960	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
IUD25_RS02965	COG0768	penicillin binding
IUD25_RS02970	COG0772	Belongs to the SEDS family
IUD25_RS02980	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IUD25_RS03000	COG2894	cell division
IUD25_RS03020	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
IUD25_RS03035	COG2353	YceI-like domain
IUD25_RS03105	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
IUD25_RS03110	COG4208	sulfate ABC transporter
IUD25_RS03135	COG1846	Transcriptional regulator
IUD25_RS03175	COG0741	lytic transglycosylase activity
IUD25_RS03185	COG1999	signal sequence binding
IUD25_RS03210	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IUD25_RS03245	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IUD25_RS03255	COG0514	ATP-dependent DNA helicase (RecQ)
IUD25_RS03260	COG0783	Belongs to the Dps family
IUD25_RS03265	COG1643	Atp-dependent helicase
IUD25_RS03275	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
IUD25_RS03280	COG1845	cytochrome c oxidase, subunit III
IUD25_RS03285	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IUD25_RS03290	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IUD25_RS03295	COG0142	geranyltranstransferase activity
IUD25_RS03310	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IUD25_RS03330	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IUD25_RS03365	COG1137	ATPase activity
IUD25_RS03380	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
IUD25_RS03390	COG0271	Belongs to the BolA IbaG family
IUD25_RS03430	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IUD25_RS03440	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IUD25_RS03475	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IUD25_RS03505	COG0542	response to heat
IUD25_RS03525	COG0492	ferredoxin-NADP+ reductase activity
IUD25_RS03545	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IUD25_RS03555	COG4191	Histidine kinase
IUD25_RS03560	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IUD25_RS03565	COG1028	Short-chain dehydrogenase reductase Sdr
IUD25_RS03595	COG1609	Transcriptional regulator
IUD25_RS03600	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IUD25_RS03605	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
IUD25_RS03610	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
IUD25_RS03620	COG0726	polysaccharide deacetylase
IUD25_RS03625	COG0297	glycogen (starch) synthase activity
IUD25_RS03645	COG0719	Fe-S assembly protein
IUD25_RS03650	COG0396	ATPase activity
IUD25_RS03655	COG0719	Fe-S assembly protein
IUD25_RS03660	COG1959	2 iron, 2 sulfur cluster binding
IUD25_RS03715	COG0308	aminopeptidase N
IUD25_RS03765	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
IUD25_RS03790	COG1561	YicC-like family, N-terminal region
IUD25_RS03805	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IUD25_RS03840	COG5295	Hep Hag repeat protein
IUD25_RS03845	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IUD25_RS03850	COG1459	type II secretion system
IUD25_RS03860	COG2165	general secretion pathway protein
IUD25_RS03865	COG4970	Tfp pilus assembly protein FimT
IUD25_RS03870	COG2165	general secretion pathway protein
IUD25_RS03875	COG4795	General secretion pathway protein
IUD25_RS03880	COG3156	type II secretion system protein K
IUD25_RS03885	COG3166	PFAM Fimbrial assembly family protein
IUD25_RS03900	COG1450	Type ii and iii secretion system protein
IUD25_RS03915	COG3634	alkyl hydroperoxide reductase activity
IUD25_RS03920	COG0583	DNA-binding transcription factor activity
IUD25_RS03980	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
IUD25_RS04005	COG0567	Dehydrogenase, E1 component
IUD25_RS04010	COG2850	peptidyl-arginine hydroxylation
IUD25_RS04025	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
IUD25_RS04125	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IUD25_RS04130	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IUD25_RS04135	COG2902	Dehydrogenase
IUD25_RS04175	COG2925	Exonuclease
IUD25_RS04185	COG0025	NhaP-type Na H and K H
IUD25_RS04205	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IUD25_RS04230	COG0006	proline dipeptidase activity
IUD25_RS04240	COG0778	Nitroreductase
IUD25_RS04275	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IUD25_RS04315	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IUD25_RS04325	COG0557	exoribonuclease II activity
IUD25_RS04335	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IUD25_RS04350	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
IUD25_RS04355	COG1289	transmembrane transporter activity
IUD25_RS04375	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
IUD25_RS04385	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IUD25_RS04400	COG0596	Alpha beta hydrolase
IUD25_RS04405	COG0727	PFAM Uncharacterised protein family (UPF0153)
IUD25_RS04450	COG0840	transmembrane signaling receptor activity
IUD25_RS04455	COG0643	Histidine kinase
IUD25_RS04455	COG0784	Response regulator, receiver
IUD25_RS04455	COG2198	Histidine kinase
IUD25_RS04485	COG0285	dihydrofolate synthase activity
IUD25_RS04495	COG0339	signal peptide processing
IUD25_RS04515	COG1301	dicarboxylic acid transport
IUD25_RS04520	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IUD25_RS04530	COG2091	lysine biosynthetic process via aminoadipic acid
IUD25_RS04565	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IUD25_RS04595	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IUD25_RS04595	COG0512	Glutamine amidotransferase of anthranilate synthase
IUD25_RS04615	COG0084	hydrolase, TatD family'
IUD25_RS04635	COG0552	protein localization to endoplasmic reticulum
IUD25_RS04730	COG0824	Thioesterase
IUD25_RS04755	COG2885	chlorophyll binding
IUD25_RS04765	COG0602	queuosine metabolic process
IUD25_RS04785	COG0386	Belongs to the glutathione peroxidase family
IUD25_RS04805	COG0406	alpha-ribazole phosphatase activity
IUD25_RS04985	COG0675	Transposase, IS605 OrfB family
IUD25_RS05140	COG2369	cell adhesion
IUD25_RS05175	COG3210	domain, Protein
IUD25_RS05190	COG0582	viral genome integration into host DNA
IUD25_RS05195	COG3567	Phage-associated protein, HI1409 family
IUD25_RS05200	COG5410	chromosome segregation
IUD25_RS05225	COG3772	lysozyme
IUD25_RS05260	COG3617	BRO family, N-terminal domain
IUD25_RS05345	COG5532	Uncharacterized conserved protein (DUF2303)
IUD25_RS05375	COG0629	single-stranded DNA binding
IUD25_RS05385	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
IUD25_RS05390	COG3852	Histidine kinase
IUD25_RS05395	COG2204	response regulator
IUD25_RS05410	COG0004	ammonium transporteR
IUD25_RS05415	COG0347	Belongs to the P(II) protein family
IUD25_RS05420	COG0174	glutamine synthetase
IUD25_RS05430	COG2353	YceI-like domain
IUD25_RS05485	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
IUD25_RS05490	COG1764	response to oxidative stress
IUD25_RS05495	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IUD25_RS05540	COG1399	metal-binding, possibly nucleic acid-binding protein
IUD25_RS05550	COG0714	Associated with various cellular activities
IUD25_RS05570	COG0537	adenosine 5'-monophosphoramidase activity
IUD25_RS05585	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
IUD25_RS05625	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IUD25_RS05650	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
IUD25_RS05650	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
IUD25_RS05700	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
IUD25_RS05715	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
IUD25_RS05730	COG0251	oxidation-reduction process
IUD25_RS05795	COG3077	Addiction module antitoxin, RelB DinJ family
IUD25_RS05800	COG3041	Addiction module toxin RelE StbE family
IUD25_RS05870	COG3772	lysozyme
IUD25_RS05935	COG4197	protein conserved in bacteria, prophage-related
IUD25_RS06010	COG3617	BRO family, N-terminal domain
IUD25_RS06045	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
IUD25_RS06050	COG0392	lysyltransferase activity
IUD25_RS06050	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
IUD25_RS06060	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IUD25_RS06070	COG0463	Glycosyl transferase, family 2
IUD25_RS06115	COG3275	phosphorelay sensor kinase activity
IUD25_RS06120	COG0400	carboxylic ester hydrolase activity
IUD25_RS06140	COG2226	methyltransferase
IUD25_RS06170	COG2027	D-alanyl-D-alanine carboxypeptidase
IUD25_RS06180	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IUD25_RS06210	COG0386	Belongs to the glutathione peroxidase family
IUD25_RS06215	COG1131	(ABC) transporter
IUD25_RS06245	COG3657	addiction module killer protein
IUD25_RS06250	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IUD25_RS06355	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
IUD25_RS06360	COG0488	(ABC) transporter
IUD25_RS06370	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
IUD25_RS06380	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IUD25_RS06380	COG4651	solute:proton antiporter activity
IUD25_RS06440	COG0859	PFAM glycosyl transferase family 9
IUD25_RS06455	COG0631	protein serine/threonine phosphatase activity
IUD25_RS06460	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IUD25_RS06495	COG2183	response to ionizing radiation
IUD25_RS06510	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
IUD25_RS06515	COG3118	belongs to the thioredoxin family
IUD25_RS06565	COG2951	lytic endotransglycosylase activity
IUD25_RS06570	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IUD25_RS06685	COG0277	FAD linked oxidase domain protein
IUD25_RS06690	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IUD25_RS06695	COG0531	amino acid
IUD25_RS06785	COG0460	homoserine dehydrogenase
IUD25_RS06785	COG0527	aspartate kinase activity
IUD25_RS06805	COG1686	Belongs to the peptidase S11 family
IUD25_RS06835	COG4953	penicillin-binding protein 1C
IUD25_RS06860	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IUD25_RS06925	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IUD25_RS06930	COG0823	Involved in the tonB-independent uptake of proteins
IUD25_RS06930	COG1506	peptidase
IUD25_RS06935	COG1297	OPT oligopeptide transporter protein
IUD25_RS06965	COG0676	glucose-6-phosphate 1-epimerase activity
IUD25_RS06975	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IUD25_RS06980	COG1335	isochorismatase
IUD25_RS06985	COG0318	PFAM AMP-dependent synthetase and ligase
IUD25_RS06995	COG0463	Glycosyl transferase, family 2
IUD25_RS07010	COG1192	Involved in chromosome partitioning
IUD25_RS07070	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IUD25_RS07115	COG0489	protein tyrosine kinase activity
IUD25_RS07125	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IUD25_RS07220	COG0077	Prephenate dehydratase
IUD25_RS07220	COG1605	Chorismate mutase
IUD25_RS07235	COG1668	transmembrane transport
IUD25_RS07240	COG4555	ABC transporter
IUD25_RS07265	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
IUD25_RS07275	COG1605	Chorismate mutase
IUD25_RS07275	COG0287	Prephenate dehydrogenase
IUD25_RS07310	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IUD25_RS07335	COG1278	Cold shock
IUD25_RS07345	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
IUD25_RS07355	COG2954	triphosphatase activity
IUD25_RS07370	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
IUD25_RS07375	COG0438	transferase activity, transferring glycosyl groups
IUD25_RS07385	COG0438	transferase activity, transferring glycosyl groups
IUD25_RS07450	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IUD25_RS07455	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IUD25_RS07470	COG1064	alcohol dehydrogenase
IUD25_RS07490	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
IUD25_RS07500	COG0436	Aminotransferase
IUD25_RS07580	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IUD25_RS07580	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
IUD25_RS07630	COG0196	riboflavin kinase activity
IUD25_RS07635	COG0728	peptidoglycan biosynthetic process
IUD25_RS07640	COG0268	Binds directly to 16S ribosomal RNA
IUD25_RS07690	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IUD25_RS07705	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
IUD25_RS07760	COG0395	ABC-type sugar transport system, permease component
IUD25_RS07765	COG1175	transmembrane transport
IUD25_RS07795	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
IUD25_RS07815	COG0436	Aminotransferase
IUD25_RS07875	COG5434	Belongs to the glycosyl hydrolase 28 family
IUD25_RS07900	COG0402	S-adenosylhomocysteine deaminase activity
IUD25_RS07910	COG1509	lysine 2,3-aminomutase activity
IUD25_RS07945	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IUD25_RS07950	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IUD25_RS07965	COG1028	Short-chain dehydrogenase reductase Sdr
IUD25_RS08010	COG0142	geranyltranstransferase activity
IUD25_RS08030	COG1301	dicarboxylic acid transport
IUD25_RS08040	COG0791	NLP P60 protein
IUD25_RS08045	COG0791	NLP P60 protein
IUD25_RS08055	COG2311	Membrane
IUD25_RS08070	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IUD25_RS08125	COG0352	thiamine-phosphate diphosphorylase activity
IUD25_RS08125	COG0351	phosphomethylpyrimidine kinase
IUD25_RS08135	COG1324	tolerance protein
IUD25_RS08170	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IUD25_RS08175	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IUD25_RS08180	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
IUD25_RS08195	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IUD25_RS08215	COG4774	siderophore transport
IUD25_RS08240	COG1477	protein flavinylation
IUD25_RS08245	COG1555	photosystem II stabilization
IUD25_RS08250	COG3178	'Phosphotransferase
IUD25_RS08255	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IUD25_RS08265	COG0628	permease
IUD25_RS08280	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IUD25_RS08305	COG3590	peptidase
IUD25_RS08355	COG0805	protein transport
IUD25_RS08365	COG0519	Catalyzes the synthesis of GMP from XMP
IUD25_RS08365	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IUD25_RS08375	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
IUD25_RS08390	COG3107	peptidoglycan biosynthetic process
IUD25_RS08415	COG2878	Part of a membrane complex involved in electron transport
IUD25_RS08490	COG0629	single-stranded DNA binding
IUD25_RS08515	COG0827	DNA restriction-modification system
IUD25_RS08520	COG0827	DNA restriction-modification system
IUD25_RS08560	COG4968	Prepilin-type N-terminal cleavage methylation domain
IUD25_RS08565	COG1611	Belongs to the LOG family
IUD25_RS08570	COG4943	cyclic-guanylate-specific phosphodiesterase activity
IUD25_RS08575	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IUD25_RS08585	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IUD25_RS08615	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IUD25_RS08630	COG0330	HflC and HflK could
IUD25_RS08635	COG0330	HflC and HflK could
IUD25_RS08640	COG0604	alcohol dehydrogenase
IUD25_RS08670	COG1183	phosphatidylcholine synthase activity
IUD25_RS08690	COG0668	transmembrane transport
IUD25_RS08695	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IUD25_RS08710	COG1610	YqeY-like protein
IUD25_RS08720	COG0358	DNA primase activity
IUD25_RS08760	COG1074	ATP-dependent DNA helicase activity
IUD25_RS08765	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
IUD25_RS08770	COG1127	ABC transporter
IUD25_RS08775	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IUD25_RS08795	COG2853	Lipoprotein
IUD25_RS08805	COG1116	anion transmembrane transporter activity
IUD25_RS08815	COG0531	amino acid
IUD25_RS08820	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IUD25_RS08825	COG0861	Integral membrane protein TerC family
IUD25_RS08855	COG2193	ferroxidase activity
IUD25_RS08945	COG2194	sulfuric ester hydrolase activity
IUD25_RS08985	COG0667	Aldo Keto reductase
IUD25_RS08990	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IUD25_RS09000	COG0305	Participates in initiation and elongation during chromosome replication
IUD25_RS09030	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IUD25_RS09040	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IUD25_RS09045	COG0277	FAD linked oxidase domain protein
IUD25_RS09060	COG4206	TonB-dependent receptor
IUD25_RS09160	COG3617	BRO family, N-terminal domain
IUD25_RS09230	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IUD25_RS09250	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
IUD25_RS09275	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IUD25_RS09275	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IUD25_RS09295	COG0488	(ABC) transporter
IUD25_RS09305	COG3011	Protein conserved in bacteria
IUD25_RS09340	COG1918	ferrous iron import across plasma membrane
IUD25_RS09340	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
IUD25_RS09350	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
IUD25_RS09375	COG0758	DNA mediated transformation
IUD25_RS09420	COG2969	positive regulation of protein catabolic process
IUD25_RS09425	COG0625	glutathione transferase activity
IUD25_RS09430	COG2857	Cytochrome c1
IUD25_RS09435	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
IUD25_RS09440	COG0723	plastoquinol--plastocyanin reductase activity
IUD25_RS09445	COG0741	lytic transglycosylase activity
IUD25_RS09455	COG1702	phosphate starvation-inducible protein PhoH
IUD25_RS09470	COG4535	Mg2 and Co2 transporter CorC
IUD25_RS09480	COG0598	Magnesium transport protein CorA
IUD25_RS09540	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IUD25_RS09550	COG1199	ATP-dependent helicase activity
IUD25_RS09565	COG0288	reversible hydration of carbon dioxide
IUD25_RS09590	COG2011	ABC-type metal ion transport system permease component
IUD25_RS09610	COG0508	dehydrogenase complex catalyzes the overall conversion of
IUD25_RS09615	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IUD25_RS09630	COG0626	cystathionine gamma-synthase activity
IUD25_RS09635	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IUD25_RS09640	COG0739	heme binding
IUD25_RS09660	COG1238	metal cluster binding
IUD25_RS09675	COG5002	protein histidine kinase activity
IUD25_RS09695	COG1388	LysM domain
IUD25_RS09695	COG3858	chitin binding
IUD25_RS09700	COG3525	Glycosyl hydrolase, family 20, catalytic domain
IUD25_RS09710	COG1472	Belongs to the glycosyl hydrolase 3 family
IUD25_RS09725	COG3537	Alpha-1,2-mannosidase
IUD25_RS09750	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IUD25_RS09755	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IUD25_RS09800	COG0469	pyruvate kinase activity
IUD25_RS09820	COG0735	belongs to the Fur family
IUD25_RS09830	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IUD25_RS09830	COG5297	Belongs to the glycosyl hydrolase family 6
IUD25_RS09855	COG4305	rare lipoprotein A
IUD25_RS09865	COG0739	heme binding
IUD25_RS09880	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
IUD25_RS09890	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
IUD25_RS09920	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IUD25_RS09935	COG3116	cell division
IUD25_RS09950	COG3273	potassium ion transport
IUD25_RS09950	COG0471	metal ion transport
IUD25_RS10005	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IUD25_RS10065	COG0860	N-Acetylmuramoyl-L-alanine amidase
IUD25_RS10070	COG0802	atpase or kinase
IUD25_RS10075	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
IUD25_RS10075	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IUD25_RS10175	COG0745	RESPONSE REGULATOR receiver
IUD25_RS10180	COG0642	Histidine kinase
IUD25_RS10190	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
IUD25_RS10235	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
IUD25_RS10245	COG2831	hemolysin activation secretion protein
IUD25_RS10270	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
IUD25_RS10310	COG0316	Belongs to the HesB IscA family
IUD25_RS10350	COG0697	spore germination
IUD25_RS10355	COG0671	phosphoesterase, PA-phosphatase related
IUD25_RS10370	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
IUD25_RS10390	COG1132	(ABC) transporter
IUD25_RS10395	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IUD25_RS10400	COG1538	Outer membrane efflux protein
IUD25_RS10425	COG0745	RESPONSE REGULATOR receiver
IUD25_RS10430	COG4783	chaperone-mediated protein folding
IUD25_RS10440	COG0473	3-isopropylmalate dehydrogenase activity
IUD25_RS10450	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IUD25_RS10455	COG3083	sulfuric ester hydrolase activity
IUD25_RS10460	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
IUD25_RS10485	COG0564	pseudouridine synthase activity
IUD25_RS10490	COG1530	ribonuclease E activity
IUD25_RS10495	COG2197	response regulator
IUD25_RS10510	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IUD25_RS10525	COG0488	(ABC) transporter
IUD25_RS10540	COG1278	Cold shock
IUD25_RS10640	COG0012	GTP binding
IUD25_RS10735	COG2095	MarC family integral membrane protein
IUD25_RS10745	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
IUD25_RS10770	COG2132	Multicopper oxidase
IUD25_RS10780	COG0210	DNA helicase
IUD25_RS10790	COG0616	signal peptide processing
IUD25_RS10810	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IUD25_RS10830	COG2201	protein-glutamate methylesterase activity
IUD25_RS10835	COG2177	Part of the ABC transporter FtsEX involved in
IUD25_RS10840	COG2884	Cell division ATP-binding protein ftsE
IUD25_RS10850	COG3118	belongs to the thioredoxin family
IUD25_RS10855	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
IUD25_RS10870	COG0793	Belongs to the peptidase S41A family
IUD25_RS10875	COG4942	peptidase
IUD25_RS10890	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IUD25_RS10895	COG0493	'glutamate synthase
IUD25_RS10900	COG0070	glutamate synthase
IUD25_RS10900	COG0067	glutamate synthase
IUD25_RS10900	COG0069	glutamate synthase activity
IUD25_RS10950	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
IUD25_RS11000	COG4942	peptidase
IUD25_RS11145	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IUD25_RS11150	COG3657	addiction module killer protein
IUD25_RS11220	COG3210	domain, Protein
IUD25_RS11255	COG3451	type IV secretory pathway VirB4
IUD25_RS11310	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
IUD25_RS11415	COG0675	Transposase, IS605 OrfB family
IUD25_RS11435	COG0629	single-stranded DNA binding
IUD25_RS11445	COG4962	Type ii secretion system protein e