locus-tag	class	description
XFLM_RS00005	COG0488	(ABC) transporter
XFLM_RS00015	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
XFLM_RS00025	COG4651	solute:proton antiporter activity
XFLM_RS00025	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
XFLM_RS00085	COG0859	PFAM glycosyl transferase family 9
XFLM_RS00100	COG0631	protein serine/threonine phosphatase activity
XFLM_RS00105	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
XFLM_RS00130	COG2183	response to ionizing radiation
XFLM_RS00145	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
XFLM_RS00150	COG3118	belongs to the thioredoxin family
XFLM_RS00190	COG2951	lytic endotransglycosylase activity
XFLM_RS00195	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
XFLM_RS00335	COG0277	FAD linked oxidase domain protein
XFLM_RS00340	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
XFLM_RS00345	COG0531	amino acid
XFLM_RS00350	COG0531	amino acid
XFLM_RS00430	COG0460	homoserine dehydrogenase
XFLM_RS00430	COG0527	aspartate kinase activity
XFLM_RS00450	COG1686	Belongs to the peptidase S11 family
XFLM_RS00475	COG4953	penicillin-binding protein 1C
XFLM_RS00500	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
XFLM_RS00565	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XFLM_RS00570	COG0823	Involved in the tonB-independent uptake of proteins
XFLM_RS00570	COG1506	peptidase
XFLM_RS00575	COG1297	OPT oligopeptide transporter protein
XFLM_RS00600	COG0676	glucose-6-phosphate 1-epimerase activity
XFLM_RS00610	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
XFLM_RS00615	COG1335	isochorismatase
XFLM_RS00620	COG0318	PFAM AMP-dependent synthetase and ligase
XFLM_RS00630	COG0463	Glycosyl transferase, family 2
XFLM_RS00645	COG1192	Involved in chromosome partitioning
XFLM_RS00700	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
XFLM_RS00750	COG0489	protein tyrosine kinase activity
XFLM_RS00760	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
XFLM_RS00875	COG1668	transmembrane transport
XFLM_RS00880	COG4555	ABC transporter
XFLM_RS00905	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
XFLM_RS00915	COG0287	Prephenate dehydrogenase
XFLM_RS00915	COG1605	Chorismate mutase
XFLM_RS00950	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XFLM_RS00975	COG1278	Cold shock
XFLM_RS00985	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
XFLM_RS00995	COG2954	triphosphatase activity
XFLM_RS01010	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
XFLM_RS01015	COG0438	transferase activity, transferring glycosyl groups
XFLM_RS01030	COG0438	transferase activity, transferring glycosyl groups
XFLM_RS01090	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XFLM_RS01095	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XFLM_RS01110	COG1064	alcohol dehydrogenase
XFLM_RS01125	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
XFLM_RS01135	COG0436	Aminotransferase
XFLM_RS01230	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XFLM_RS01230	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
XFLM_RS01285	COG0196	riboflavin kinase activity
XFLM_RS01290	COG0728	peptidoglycan biosynthetic process
XFLM_RS01295	COG0268	Binds directly to 16S ribosomal RNA
XFLM_RS01345	COG1210	Utp--glucose-1-phosphate uridylyltransferase
XFLM_RS01360	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
XFLM_RS01415	COG1175	transmembrane transport
XFLM_RS01440	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
XFLM_RS01445	COG1187	pseudouridine synthase activity
XFLM_RS01460	COG0436	Aminotransferase
XFLM_RS01515	COG5434	Belongs to the glycosyl hydrolase 28 family
XFLM_RS01535	COG0402	S-adenosylhomocysteine deaminase activity
XFLM_RS01545	COG1509	lysine 2,3-aminomutase activity
XFLM_RS01580	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
XFLM_RS01585	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
XFLM_RS01600	COG1028	Short-chain dehydrogenase reductase Sdr
XFLM_RS01645	COG0142	geranyltranstransferase activity
XFLM_RS01665	COG1301	dicarboxylic acid transport
XFLM_RS01675	COG0791	NLP P60 protein
XFLM_RS01680	COG0791	NLP P60 protein
XFLM_RS01690	COG2311	Membrane
XFLM_RS01700	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
XFLM_RS01750	COG0352	thiamine-phosphate diphosphorylase activity
XFLM_RS01750	COG0351	phosphomethylpyrimidine kinase
XFLM_RS01760	COG1324	tolerance protein
XFLM_RS01795	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
XFLM_RS01800	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
XFLM_RS01805	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
XFLM_RS01820	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
XFLM_RS01840	COG4774	siderophore transport
XFLM_RS01865	COG1477	protein flavinylation
XFLM_RS01870	COG1555	photosystem II stabilization
XFLM_RS01880	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
XFLM_RS01890	COG0628	permease
XFLM_RS01910	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
XFLM_RS01930	COG3590	peptidase
XFLM_RS01980	COG0805	protein transport
XFLM_RS01995	COG0519	Catalyzes the synthesis of GMP from XMP
XFLM_RS01995	COG0518	GMP synthase (glutamine-hydrolyzing) activity
XFLM_RS02005	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
XFLM_RS02025	COG3107	peptidoglycan biosynthetic process
XFLM_RS02050	COG2878	Part of a membrane complex involved in electron transport
XFLM_RS02120	COG0629	single-stranded DNA binding
XFLM_RS02145	COG0827	DNA restriction-modification system
XFLM_RS02150	COG0827	DNA restriction-modification system
XFLM_RS02185	COG4968	Prepilin-type N-terminal cleavage methylation domain
XFLM_RS02190	COG1611	Belongs to the LOG family
XFLM_RS02195	COG4943	cyclic-guanylate-specific phosphodiesterase activity
XFLM_RS02200	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
XFLM_RS02210	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XFLM_RS02240	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
XFLM_RS02255	COG0330	HflC and HflK could
XFLM_RS02260	COG0330	HflC and HflK could
XFLM_RS02265	COG0604	alcohol dehydrogenase
XFLM_RS02295	COG1183	phosphatidylcholine synthase activity
XFLM_RS02315	COG0668	transmembrane transport
XFLM_RS02320	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
XFLM_RS02335	COG1610	YqeY-like protein
XFLM_RS02345	COG0358	DNA primase activity
XFLM_RS02380	COG1074	ATP-dependent DNA helicase activity
XFLM_RS02385	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
XFLM_RS02390	COG1127	ABC transporter
XFLM_RS02395	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
XFLM_RS02415	COG2853	Lipoprotein
XFLM_RS02430	COG1116	anion transmembrane transporter activity
XFLM_RS02440	COG0531	amino acid
XFLM_RS02445	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
XFLM_RS02450	COG0861	Integral membrane protein TerC family
XFLM_RS02480	COG2193	ferroxidase activity
XFLM_RS02570	COG2194	sulfuric ester hydrolase activity
XFLM_RS02610	COG0667	Aldo Keto reductase
XFLM_RS02615	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
XFLM_RS02625	COG0305	Participates in initiation and elongation during chromosome replication
XFLM_RS02645	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
XFLM_RS02655	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
XFLM_RS02660	COG0277	FAD linked oxidase domain protein
XFLM_RS02685	COG4206	TonB-dependent receptor
XFLM_RS02875	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
XFLM_RS02880	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
XFLM_RS02895	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
XFLM_RS02920	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
XFLM_RS02920	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
XFLM_RS02940	COG0488	(ABC) transporter
XFLM_RS02950	COG3011	Protein conserved in bacteria
XFLM_RS02975	COG1918	ferrous iron import across plasma membrane
XFLM_RS02975	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
XFLM_RS02985	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
XFLM_RS03010	COG0758	DNA mediated transformation
XFLM_RS03055	COG2969	positive regulation of protein catabolic process
XFLM_RS03060	COG0625	glutathione transferase activity
XFLM_RS03065	COG2857	Cytochrome c1
XFLM_RS03075	COG0723	plastoquinol--plastocyanin reductase activity
XFLM_RS03080	COG0741	lytic transglycosylase activity
XFLM_RS03090	COG1702	phosphate starvation-inducible protein PhoH
XFLM_RS03105	COG4535	Mg2 and Co2 transporter CorC
XFLM_RS03115	COG0598	Magnesium transport protein CorA
XFLM_RS03160	COG3210	domain, Protein
XFLM_RS03180	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
XFLM_RS03200	COG0288	reversible hydration of carbon dioxide
XFLM_RS03225	COG2011	ABC-type metal ion transport system permease component
XFLM_RS03240	COG0508	dehydrogenase complex catalyzes the overall conversion of
XFLM_RS03245	COG0508	dehydrogenase complex catalyzes the overall conversion of
XFLM_RS03265	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
XFLM_RS03270	COG0739	heme binding
XFLM_RS03290	COG1238	metal cluster binding
XFLM_RS03305	COG5002	protein histidine kinase activity
XFLM_RS03330	COG1388	LysM domain
XFLM_RS03330	COG3858	chitin binding
XFLM_RS03335	COG3525	Glycosyl hydrolase, family 20, catalytic domain
XFLM_RS03360	COG3537	Alpha-1,2-mannosidase
XFLM_RS03385	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XFLM_RS03390	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XFLM_RS03430	COG0469	pyruvate kinase activity
XFLM_RS03450	COG0735	belongs to the Fur family
XFLM_RS03460	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XFLM_RS03460	COG5297	Belongs to the glycosyl hydrolase family 6
XFLM_RS03485	COG4305	rare lipoprotein A
XFLM_RS03495	COG0739	heme binding
XFLM_RS03510	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
XFLM_RS03520	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
XFLM_RS03550	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
XFLM_RS03565	COG3116	cell division
XFLM_RS03635	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
XFLM_RS03695	COG0860	N-Acetylmuramoyl-L-alanine amidase
XFLM_RS03700	COG0802	atpase or kinase
XFLM_RS03705	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
XFLM_RS03705	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
XFLM_RS03815	COG0745	RESPONSE REGULATOR receiver
XFLM_RS03820	COG0642	Histidine kinase
XFLM_RS03830	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
XFLM_RS03875	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
XFLM_RS03885	COG2831	hemolysin activation secretion protein
XFLM_RS03910	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
XFLM_RS03950	COG0316	Belongs to the HesB IscA family
XFLM_RS03985	COG0697	spore germination
XFLM_RS03990	COG0671	phosphoesterase, PA-phosphatase related
XFLM_RS04005	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
XFLM_RS04025	COG1132	(ABC) transporter
XFLM_RS04035	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
XFLM_RS04040	COG1538	Outer membrane efflux protein
XFLM_RS04065	COG0745	RESPONSE REGULATOR receiver
XFLM_RS04070	COG4783	chaperone-mediated protein folding
XFLM_RS04080	COG0473	3-isopropylmalate dehydrogenase activity
XFLM_RS04090	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
XFLM_RS04095	COG3083	sulfuric ester hydrolase activity
XFLM_RS04100	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
XFLM_RS04125	COG0564	pseudouridine synthase activity
XFLM_RS04130	COG1530	ribonuclease E activity
XFLM_RS04135	COG2197	response regulator
XFLM_RS04155	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
XFLM_RS04170	COG0488	(ABC) transporter
XFLM_RS04185	COG1278	Cold shock
XFLM_RS04370	COG2095	MarC family integral membrane protein
XFLM_RS04375	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
XFLM_RS04405	COG2132	Multicopper oxidase
XFLM_RS04415	COG0210	DNA helicase
XFLM_RS04425	COG0616	signal peptide processing
XFLM_RS04445	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
XFLM_RS04460	COG2201	protein-glutamate methylesterase activity
XFLM_RS04465	COG2177	Part of the ABC transporter FtsEX involved in
XFLM_RS04470	COG2884	Cell division ATP-binding protein ftsE
XFLM_RS04480	COG3118	belongs to the thioredoxin family
XFLM_RS04485	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
XFLM_RS04500	COG0793	Belongs to the peptidase S41A family
XFLM_RS04520	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XFLM_RS04525	COG0493	'glutamate synthase
XFLM_RS04530	COG0070	glutamate synthase
XFLM_RS04530	COG0067	glutamate synthase
XFLM_RS04530	COG0069	glutamate synthase activity
XFLM_RS04580	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
XFLM_RS04630	COG4942	peptidase
XFLM_RS04760	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
XFLM_RS04765	COG3657	addiction module killer protein
XFLM_RS04875	COG0592	DNA-directed DNA polymerase activity
XFLM_RS04890	COG0187	DNA topoisomerase II activity
XFLM_RS04900	COG0501	Belongs to the peptidase M48B family
XFLM_RS04930	COG1506	peptidase
XFLM_RS04930	COG4946	Tricorn protease homolog
XFLM_RS04930	COG0823	Involved in the tonB-independent uptake of proteins
XFLM_RS04960	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
XFLM_RS05040	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
XFLM_RS05070	COG0511	ligase activity, forming carbon-carbon bonds
XFLM_RS05075	COG0439	Biotin carboxylase
XFLM_RS05080	COG0210	DNA helicase
XFLM_RS05110	COG1040	competence protein
XFLM_RS05120	COG1752	Esterase of the alpha-beta hydrolase superfamily
XFLM_RS05165	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
XFLM_RS05175	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
XFLM_RS05210	COG3121	Chaperone
XFLM_RS05215	COG3539	Fimbrial protein
XFLM_RS05225	COG0477	Major facilitator Superfamily
XFLM_RS05230	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
XFLM_RS05245	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
XFLM_RS05255	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
XFLM_RS05265	COG1534	Rna-binding protein
XFLM_RS05300	COG1560	Kdo2-lipid A biosynthetic process
XFLM_RS05305	COG1519	Transferase
XFLM_RS05345	COG1393	Belongs to the ArsC family
XFLM_RS05355	COG0367	asparagine synthase
XFLM_RS05365	COG2070	2-Nitropropane dioxygenase
XFLM_RS05395	COG0339	signal peptide processing
XFLM_RS05410	COG2132	Multicopper oxidase
XFLM_RS05445	COG0795	lipopolysaccharide-transporting ATPase activity
XFLM_RS05480	COG4221	oxidoreductase activity
XFLM_RS05500	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
XFLM_RS05515	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
XFLM_RS05570	COG2223	nitrite transmembrane transporter activity
XFLM_RS05580	COG0739	heme binding
XFLM_RS05615	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
XFLM_RS05630	COG1028	Short-chain dehydrogenase reductase Sdr
XFLM_RS05640	COG1272	protein, Hemolysin III
XFLM_RS05645	COG0463	Glycosyl transferase, family 2
XFLM_RS05650	COG0084	hydrolase, TatD family'
XFLM_RS05680	COG0330	HflC and HflK could
XFLM_RS05685	COG3956	TIGRFAM MazG family protein
XFLM_RS05690	COG1218	3'(2'),5'-bisphosphate nucleotidase
XFLM_RS05695	COG0494	nUDIX hydrolase
XFLM_RS05705	COG1385	rRNA (uridine-N3-)-methyltransferase activity
XFLM_RS05710	COG0513	Belongs to the DEAD box helicase family
XFLM_RS05715	COG0720	synthase
XFLM_RS05740	COG1981	membrane
XFLM_RS05775	COG0512	Glutamine amidotransferase of anthranilate synthase
XFLM_RS05810	COG0006	proline dipeptidase activity
XFLM_RS05830	COG1862	Preprotein translocase
XFLM_RS05835	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
XFLM_RS05840	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
XFLM_RS05850	COG0617	tRNA 3'-terminal CCA addition
XFLM_RS05890	COG0195	Participates in both transcription termination and antitermination
XFLM_RS05920	COG1733	regulation of RNA biosynthetic process
XFLM_RS05925	COG0702	epimerase
XFLM_RS05970	COG2086	electron transfer activity
XFLM_RS06000	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
XFLM_RS06030	COG0477	Major facilitator Superfamily
XFLM_RS06050	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
XFLM_RS06055	COG0671	phosphoesterase, PA-phosphatase related
XFLM_RS06065	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
XFLM_RS06070	COG0628	permease
XFLM_RS06090	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
XFLM_RS06095	COG1090	epimerase
XFLM_RS06100	COG0318	PFAM AMP-dependent synthetase and ligase
XFLM_RS06120	COG1049	propionate catabolic process, 2-methylcitrate cycle
XFLM_RS06140	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
XFLM_RS06175	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XFLM_RS06205	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XFLM_RS06225	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
XFLM_RS06230	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
XFLM_RS06235	COG1034	ATP synthesis coupled electron transport
XFLM_RS06270	COG1007	ATP synthesis coupled electron transport
XFLM_RS06275	COG1028	Short-chain dehydrogenase reductase Sdr
XFLM_RS06280	COG2851	Citrate transporter
XFLM_RS06295	COG0642	Histidine kinase
XFLM_RS06315	COG0784	Response regulator, receiver
XFLM_RS06315	COG2205	protein histidine kinase activity
XFLM_RS06330	COG0280	phosphate acetyltransferase
XFLM_RS06330	COG0281	malic enzyme
XFLM_RS06340	COG0742	ribosomal rna small subunit methyltransferase
XFLM_RS06355	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
XFLM_RS06375	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
XFLM_RS06400	COG2166	iron-sulfur cluster assembly
XFLM_RS06430	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
XFLM_RS06505	COG1321	iron dependent repressor
XFLM_RS06525	COG1946	Acyl-CoA thioesterase
XFLM_RS06610	COG0575	Belongs to the CDS family
XFLM_RS06700	COG0354	folic acid binding
XFLM_RS06710	COG2009	succinate dehydrogenase
XFLM_RS06715	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
XFLM_RS06725	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
XFLM_RS06755	COG0811	peptide transport
XFLM_RS06805	COG3093	addiction module antidote protein HigA
XFLM_RS06815	COG2944	sequence-specific DNA binding
XFLM_RS06880	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
XFLM_RS06900	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XFLM_RS06970	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
XFLM_RS06975	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
XFLM_RS06995	COG1024	Enoyl-CoA hydratase
XFLM_RS07000	COG0019	diaminopimelate decarboxylase activity
XFLM_RS07020	COG0494	nUDIX hydrolase
XFLM_RS07050	COG0312	modulator of DNA gyrase
XFLM_RS07060	COG0312	modulator of DNA gyrase
XFLM_RS07065	COG0583	DNA-binding transcription factor activity
XFLM_RS07080	COG1064	alcohol dehydrogenase
XFLM_RS07140	COG0356	it plays a direct role in the translocation of protons across the membrane
XFLM_RS07245	COG0201	protein transport
XFLM_RS07275	COG2960	long-chain fatty acid transporting porin activity
XFLM_RS07280	COG0606	chelatase, subunit chli
XFLM_RS07370	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
XFLM_RS07375	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
XFLM_RS07390	COG1187	pseudouridine synthase activity
XFLM_RS07395	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
XFLM_RS07415	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XFLM_RS07420	COG0625	glutathione transferase activity
XFLM_RS07430	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
XFLM_RS07435	COG1217	gtp-binding protein TYPA
XFLM_RS07470	COG1131	(ABC) transporter
XFLM_RS07490	COG1643	Atp-dependent helicase
XFLM_RS07500	COG1956	GAF domain-containing protein
XFLM_RS07505	COG0729	surface antigen
XFLM_RS07510	COG2911	Protein conserved in bacteria
XFLM_RS07595	COG0668	transmembrane transport
XFLM_RS07660	COG2733	membrane
XFLM_RS07665	COG1253	flavin adenine dinucleotide binding
XFLM_RS07730	COG0644	oxidoreductase
XFLM_RS07730	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
XFLM_RS07745	COG3218	ABC-type transport auxiliary lipoprotein component
XFLM_RS07745	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
XFLM_RS07750	COG1127	ABC transporter
XFLM_RS07755	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
XFLM_RS07775	COG1077	Cell shape determining protein MreB Mrl
XFLM_RS07780	COG1792	Involved in formation and maintenance of cell shape
XFLM_RS07785	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
XFLM_RS07790	COG0768	penicillin binding
XFLM_RS07795	COG0772	Belongs to the SEDS family
XFLM_RS07805	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
XFLM_RS07825	COG2894	cell division
XFLM_RS07850	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
XFLM_RS07865	COG2353	YceI-like domain
XFLM_RS07935	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
XFLM_RS07940	COG4208	sulfate ABC transporter
XFLM_RS07965	COG1846	Transcriptional regulator
XFLM_RS08005	COG0741	lytic transglycosylase activity
XFLM_RS08015	COG1999	signal sequence binding
XFLM_RS08035	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
XFLM_RS08070	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
XFLM_RS08080	COG0514	ATP-dependent DNA helicase (RecQ)
XFLM_RS08085	COG0783	Belongs to the Dps family
XFLM_RS08090	COG1643	Atp-dependent helicase
XFLM_RS08100	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
XFLM_RS08105	COG1845	cytochrome c oxidase, subunit III
XFLM_RS08110	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
XFLM_RS08115	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
XFLM_RS08120	COG0142	geranyltranstransferase activity
XFLM_RS08130	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
XFLM_RS08150	COG2239	Acts as a magnesium transporter
XFLM_RS08160	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
XFLM_RS08195	COG1137	ATPase activity
XFLM_RS08210	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
XFLM_RS08220	COG0271	Belongs to the BolA IbaG family
XFLM_RS08260	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
XFLM_RS08270	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
XFLM_RS08305	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
XFLM_RS08335	COG0542	response to heat
XFLM_RS08355	COG0492	ferredoxin-NADP+ reductase activity
XFLM_RS08375	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
XFLM_RS08390	COG4191	Histidine kinase
XFLM_RS08395	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
XFLM_RS08400	COG1028	Short-chain dehydrogenase reductase Sdr
XFLM_RS08430	COG1609	Transcriptional regulator
XFLM_RS08435	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
XFLM_RS08440	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
XFLM_RS08445	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
XFLM_RS08455	COG0726	polysaccharide deacetylase
XFLM_RS08460	COG0297	glycogen (starch) synthase activity
XFLM_RS08480	COG0719	Fe-S assembly protein
XFLM_RS08485	COG0396	ATPase activity
XFLM_RS08490	COG0719	Fe-S assembly protein
XFLM_RS08495	COG1959	2 iron, 2 sulfur cluster binding
XFLM_RS08545	COG0308	aminopeptidase N
XFLM_RS08595	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
XFLM_RS08620	COG1561	YicC-like family, N-terminal region
XFLM_RS08635	COG0635	Involved in the biosynthesis of porphyrin-containing compound
XFLM_RS08670	COG5295	Hep Hag repeat protein
XFLM_RS08675	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
XFLM_RS08680	COG1459	type II secretion system
XFLM_RS08685	COG2165	general secretion pathway protein
XFLM_RS08690	COG4970	Tfp pilus assembly protein FimT
XFLM_RS08695	COG2165	general secretion pathway protein
XFLM_RS08700	COG4795	General secretion pathway protein
XFLM_RS08705	COG3156	type II secretion system protein K
XFLM_RS08710	COG3166	PFAM Fimbrial assembly family protein
XFLM_RS08725	COG1450	Type ii and iii secretion system protein
XFLM_RS08740	COG3634	alkyl hydroperoxide reductase activity
XFLM_RS08745	COG0583	DNA-binding transcription factor activity
XFLM_RS08800	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
XFLM_RS08825	COG0567	Dehydrogenase, E1 component
XFLM_RS08830	COG2850	peptidyl-arginine hydroxylation
XFLM_RS08850	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
XFLM_RS08945	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XFLM_RS08950	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XFLM_RS08995	COG2925	Exonuclease
XFLM_RS09010	COG0025	NhaP-type Na H and K H
XFLM_RS09030	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
XFLM_RS09050	COG0006	proline dipeptidase activity
XFLM_RS09060	COG0778	Nitroreductase
XFLM_RS09085	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
XFLM_RS09125	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
XFLM_RS09135	COG0557	exoribonuclease II activity
XFLM_RS09145	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
XFLM_RS09165	COG1289	transmembrane transporter activity
XFLM_RS09195	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
XFLM_RS09205	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
XFLM_RS09225	COG0596	Alpha beta hydrolase
XFLM_RS09230	COG0727	PFAM Uncharacterised protein family (UPF0153)
XFLM_RS09275	COG0840	transmembrane signaling receptor activity
XFLM_RS09280	COG0643	Histidine kinase
XFLM_RS09280	COG0784	Response regulator, receiver
XFLM_RS09280	COG2198	Histidine kinase
XFLM_RS09310	COG0285	dihydrofolate synthase activity
XFLM_RS09320	COG0339	signal peptide processing
XFLM_RS09340	COG1301	dicarboxylic acid transport
XFLM_RS09345	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
XFLM_RS09355	COG2091	lysine biosynthetic process via aminoadipic acid
XFLM_RS09405	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
XFLM_RS09445	COG0084	hydrolase, TatD family'
XFLM_RS09465	COG0552	protein localization to endoplasmic reticulum
XFLM_RS09510	COG0824	Thioesterase
XFLM_RS09535	COG2885	chlorophyll binding
XFLM_RS09545	COG0602	queuosine metabolic process
XFLM_RS09565	COG0386	Belongs to the glutathione peroxidase family
XFLM_RS09585	COG0406	alpha-ribazole phosphatase activity
XFLM_RS09820	COG2369	cell adhesion
XFLM_RS09870	COG0582	viral genome integration into host DNA
XFLM_RS09880	COG5410	chromosome segregation
XFLM_RS09940	COG3617	BRO family, N-terminal domain
XFLM_RS10015	COG5532	Uncharacterized conserved protein (DUF2303)
XFLM_RS10040	COG0629	single-stranded DNA binding
XFLM_RS10050	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
XFLM_RS10055	COG3852	Histidine kinase
XFLM_RS10060	COG2204	response regulator
XFLM_RS10070	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
XFLM_RS10075	COG0004	ammonium transporteR
XFLM_RS10080	COG0347	Belongs to the P(II) protein family
XFLM_RS10085	COG0174	glutamine synthetase
XFLM_RS10095	COG2353	YceI-like domain
XFLM_RS10155	COG1764	response to oxidative stress
XFLM_RS10160	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
XFLM_RS10205	COG1399	metal-binding, possibly nucleic acid-binding protein
XFLM_RS10215	COG0714	Associated with various cellular activities
XFLM_RS10235	COG0537	adenosine 5'-monophosphoramidase activity
XFLM_RS10250	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
XFLM_RS10285	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
XFLM_RS10310	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
XFLM_RS10310	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
XFLM_RS10360	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
XFLM_RS10390	COG0251	oxidation-reduction process
XFLM_RS10455	COG3077	Addiction module antitoxin, RelB DinJ family
XFLM_RS10460	COG3041	Addiction module toxin RelE StbE family
XFLM_RS10530	COG3772	lysozyme
XFLM_RS10630	COG3617	BRO family, N-terminal domain
XFLM_RS10660	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
XFLM_RS10665	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
XFLM_RS10665	COG0392	lysyltransferase activity
XFLM_RS10680	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
XFLM_RS10690	COG0463	Glycosyl transferase, family 2
XFLM_RS10735	COG3275	phosphorelay sensor kinase activity
XFLM_RS10740	COG0400	carboxylic ester hydrolase activity
XFLM_RS10760	COG2226	methyltransferase
XFLM_RS10780	COG2027	D-alanyl-D-alanine carboxypeptidase
XFLM_RS10790	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
XFLM_RS10820	COG0386	Belongs to the glutathione peroxidase family
XFLM_RS10825	COG1131	(ABC) transporter
XFLM_RS10855	COG3657	addiction module killer protein
XFLM_RS10860	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
XFLM_RS11130	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
XFLM_RS11155	COG3617	BRO family, N-terminal domain