locus-tag	class	description
D1605_RS00010	COG0592	DNA-directed DNA polymerase activity
D1605_RS00020	COG0187	DNA topoisomerase II activity
D1605_RS00030	COG0501	Belongs to the peptidase M48B family
D1605_RS00060	COG4946	Tricorn protease homolog
D1605_RS00060	COG1506	peptidase
D1605_RS00060	COG0823	Involved in the tonB-independent uptake of proteins
D1605_RS00090	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
D1605_RS00145	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
D1605_RS00155	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
D1605_RS00165	COG0511	ligase activity, forming carbon-carbon bonds
D1605_RS00170	COG0439	Biotin carboxylase
D1605_RS00175	COG0210	DNA helicase
D1605_RS00205	COG1040	competence protein
D1605_RS00215	COG1752	Esterase of the alpha-beta hydrolase superfamily
D1605_RS00255	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
D1605_RS00265	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
D1605_RS00290	COG3121	Chaperone
D1605_RS00295	COG3539	Fimbrial protein
D1605_RS00305	COG1546	Belongs to the CinA family
D1605_RS00310	COG0477	Major facilitator Superfamily
D1605_RS00315	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
D1605_RS00330	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
D1605_RS00335	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D1605_RS00345	COG1534	Rna-binding protein
D1605_RS00375	COG1560	Kdo2-lipid A biosynthetic process
D1605_RS00380	COG1519	Transferase
D1605_RS00420	COG1393	Belongs to the ArsC family
D1605_RS00430	COG0367	asparagine synthase
D1605_RS00440	COG2070	2-Nitropropane dioxygenase
D1605_RS00470	COG0339	signal peptide processing
D1605_RS00485	COG2132	Multicopper oxidase
D1605_RS00515	COG0795	lipopolysaccharide-transporting ATPase activity
D1605_RS00550	COG4221	oxidoreductase activity
D1605_RS00570	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
D1605_RS00590	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D1605_RS00640	COG2223	nitrite transmembrane transporter activity
D1605_RS00650	COG0739	heme binding
D1605_RS00685	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
D1605_RS00700	COG1028	Short-chain dehydrogenase reductase Sdr
D1605_RS00710	COG1272	protein, Hemolysin III
D1605_RS00715	COG0463	Glycosyl transferase, family 2
D1605_RS00720	COG0084	hydrolase, TatD family'
D1605_RS00750	COG0330	HflC and HflK could
D1605_RS00755	COG3956	TIGRFAM MazG family protein
D1605_RS00760	COG1218	3'(2'),5'-bisphosphate nucleotidase
D1605_RS00765	COG0494	nUDIX hydrolase
D1605_RS00775	COG1385	rRNA (uridine-N3-)-methyltransferase activity
D1605_RS00780	COG0513	Belongs to the DEAD box helicase family
D1605_RS00785	COG0720	synthase
D1605_RS00810	COG1981	membrane
D1605_RS00845	COG0512	Glutamine amidotransferase of anthranilate synthase
D1605_RS00880	COG0006	proline dipeptidase activity
D1605_RS00900	COG1862	Preprotein translocase
D1605_RS00905	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D1605_RS00910	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D1605_RS00920	COG0617	tRNA 3'-terminal CCA addition
D1605_RS00960	COG0195	Participates in both transcription termination and antitermination
D1605_RS00990	COG1733	regulation of RNA biosynthetic process
D1605_RS00995	COG0702	epimerase
D1605_RS01040	COG2086	electron transfer activity
D1605_RS01070	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D1605_RS01100	COG0477	Major facilitator Superfamily
D1605_RS01120	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D1605_RS01125	COG0671	phosphoesterase, PA-phosphatase related
D1605_RS01140	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
D1605_RS01145	COG0628	permease
D1605_RS01165	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D1605_RS01170	COG1090	epimerase
D1605_RS01175	COG0318	PFAM AMP-dependent synthetase and ligase
D1605_RS01195	COG1049	propionate catabolic process, 2-methylcitrate cycle
D1605_RS01240	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D1605_RS01265	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D1605_RS01285	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
D1605_RS01290	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
D1605_RS01295	COG1034	ATP synthesis coupled electron transport
D1605_RS01330	COG1007	ATP synthesis coupled electron transport
D1605_RS01335	COG1028	Short-chain dehydrogenase reductase Sdr
D1605_RS01340	COG2851	Citrate transporter
D1605_RS01355	COG0642	Histidine kinase
D1605_RS01370	COG0784	Response regulator, receiver
D1605_RS01370	COG2205	protein histidine kinase activity
D1605_RS01390	COG0280	phosphate acetyltransferase
D1605_RS01390	COG0281	malic enzyme
D1605_RS01400	COG0742	ribosomal rna small subunit methyltransferase
D1605_RS01420	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
D1605_RS01440	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D1605_RS01465	COG2166	iron-sulfur cluster assembly
D1605_RS01490	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D1605_RS01565	COG1321	iron dependent repressor
D1605_RS01585	COG1946	Acyl-CoA thioesterase
D1605_RS01670	COG0575	Belongs to the CDS family
D1605_RS01765	COG0354	folic acid binding
D1605_RS01775	COG2009	succinate dehydrogenase
D1605_RS01780	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
D1605_RS01790	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
D1605_RS01820	COG0811	peptide transport
D1605_RS01870	COG3093	addiction module antidote protein HigA
D1605_RS01880	COG2944	sequence-specific DNA binding
D1605_RS01945	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
D1605_RS01965	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D1605_RS02030	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
D1605_RS02055	COG1024	Enoyl-CoA hydratase
D1605_RS02060	COG0019	diaminopimelate decarboxylase activity
D1605_RS02080	COG0494	nUDIX hydrolase
D1605_RS02085	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
D1605_RS02110	COG0312	modulator of DNA gyrase
D1605_RS02120	COG0312	modulator of DNA gyrase
D1605_RS02125	COG0583	DNA-binding transcription factor activity
D1605_RS02140	COG1064	alcohol dehydrogenase
D1605_RS02195	COG0356	it plays a direct role in the translocation of protons across the membrane
D1605_RS02315	COG0201	protein transport
D1605_RS02345	COG2960	long-chain fatty acid transporting porin activity
D1605_RS02350	COG0606	chelatase, subunit chli
D1605_RS02375	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
D1605_RS02435	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D1605_RS02440	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D1605_RS02455	COG1187	pseudouridine synthase activity
D1605_RS02460	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D1605_RS02480	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D1605_RS02485	COG0625	glutathione transferase activity
D1605_RS02495	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
D1605_RS02500	COG1217	gtp-binding protein TYPA
D1605_RS02540	COG0842	Transport permease protein
D1605_RS02545	COG1131	(ABC) transporter
D1605_RS02565	COG1643	Atp-dependent helicase
D1605_RS02575	COG1956	GAF domain-containing protein
D1605_RS02580	COG0729	surface antigen
D1605_RS02585	COG2911	Protein conserved in bacteria
D1605_RS02595	COG0582	viral genome integration into host DNA
D1605_RS02765	COG0668	transmembrane transport
D1605_RS02795	COG5297	Belongs to the glycosyl hydrolase family 6
D1605_RS02830	COG2733	membrane
D1605_RS02835	COG1253	flavin adenine dinucleotide binding
D1605_RS02900	COG0644	oxidoreductase
D1605_RS02900	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
D1605_RS02915	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
D1605_RS02915	COG3218	ABC-type transport auxiliary lipoprotein component
D1605_RS02920	COG1127	ABC transporter
D1605_RS02925	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D1605_RS02960	COG1077	Cell shape determining protein MreB Mrl
D1605_RS02965	COG1792	Involved in formation and maintenance of cell shape
D1605_RS02970	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
D1605_RS02975	COG0768	penicillin binding
D1605_RS02980	COG0772	Belongs to the SEDS family
D1605_RS02990	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D1605_RS03010	COG2894	cell division
D1605_RS03030	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
D1605_RS03045	COG2353	YceI-like domain
D1605_RS03115	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
D1605_RS03120	COG4208	sulfate ABC transporter
D1605_RS03145	COG1846	Transcriptional regulator
D1605_RS03185	COG0741	lytic transglycosylase activity
D1605_RS03195	COG1999	signal sequence binding
D1605_RS03220	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
D1605_RS03255	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D1605_RS03265	COG0514	ATP-dependent DNA helicase (RecQ)
D1605_RS03270	COG0783	Belongs to the Dps family
D1605_RS03275	COG1643	Atp-dependent helicase
D1605_RS03285	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
D1605_RS03290	COG1845	cytochrome c oxidase, subunit III
D1605_RS03295	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D1605_RS03300	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
D1605_RS03305	COG0142	geranyltranstransferase activity
D1605_RS03320	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D1605_RS03340	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D1605_RS03375	COG1137	ATPase activity
D1605_RS03390	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
D1605_RS03400	COG0271	Belongs to the BolA IbaG family
D1605_RS03440	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D1605_RS03450	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D1605_RS03485	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D1605_RS03515	COG0542	response to heat
D1605_RS03535	COG0492	ferredoxin-NADP+ reductase activity
D1605_RS03555	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
D1605_RS03565	COG4191	Histidine kinase
D1605_RS03570	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
D1605_RS03575	COG1028	Short-chain dehydrogenase reductase Sdr
D1605_RS03605	COG1609	Transcriptional regulator
D1605_RS03610	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D1605_RS03615	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
D1605_RS03620	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
D1605_RS03630	COG0726	polysaccharide deacetylase
D1605_RS03635	COG0297	glycogen (starch) synthase activity
D1605_RS03655	COG0719	Fe-S assembly protein
D1605_RS03660	COG0396	ATPase activity
D1605_RS03665	COG0719	Fe-S assembly protein
D1605_RS03670	COG1959	2 iron, 2 sulfur cluster binding
D1605_RS03725	COG0308	aminopeptidase N
D1605_RS03775	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
D1605_RS03800	COG1561	YicC-like family, N-terminal region
D1605_RS03815	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D1605_RS03850	COG5295	Hep Hag repeat protein
D1605_RS03855	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
D1605_RS03860	COG1459	type II secretion system
D1605_RS03870	COG2165	general secretion pathway protein
D1605_RS03875	COG4970	Tfp pilus assembly protein FimT
D1605_RS03880	COG2165	general secretion pathway protein
D1605_RS03885	COG4795	General secretion pathway protein
D1605_RS03890	COG3156	type II secretion system protein K
D1605_RS03895	COG3166	PFAM Fimbrial assembly family protein
D1605_RS03910	COG1450	Type ii and iii secretion system protein
D1605_RS03925	COG3634	alkyl hydroperoxide reductase activity
D1605_RS03930	COG0583	DNA-binding transcription factor activity
D1605_RS03990	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
D1605_RS04015	COG0567	Dehydrogenase, E1 component
D1605_RS04020	COG2850	peptidyl-arginine hydroxylation
D1605_RS04035	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
D1605_RS04135	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D1605_RS04140	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D1605_RS04145	COG2902	Dehydrogenase
D1605_RS04185	COG2925	Exonuclease
D1605_RS04195	COG0025	NhaP-type Na H and K H
D1605_RS04215	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
D1605_RS04240	COG0006	proline dipeptidase activity
D1605_RS04250	COG0778	Nitroreductase
D1605_RS04285	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D1605_RS04325	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D1605_RS04335	COG0557	exoribonuclease II activity
D1605_RS04345	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
D1605_RS04360	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
D1605_RS04365	COG1289	transmembrane transporter activity
D1605_RS04385	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
D1605_RS04395	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D1605_RS04410	COG0596	Alpha beta hydrolase
D1605_RS04415	COG0727	PFAM Uncharacterised protein family (UPF0153)
D1605_RS04460	COG0840	transmembrane signaling receptor activity
D1605_RS04465	COG0643	Histidine kinase
D1605_RS04465	COG2198	Histidine kinase
D1605_RS04465	COG0784	Response regulator, receiver
D1605_RS04495	COG0285	dihydrofolate synthase activity
D1605_RS04505	COG0339	signal peptide processing
D1605_RS04525	COG1301	dicarboxylic acid transport
D1605_RS04530	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
D1605_RS04540	COG2091	lysine biosynthetic process via aminoadipic acid
D1605_RS04580	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
D1605_RS04610	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
D1605_RS04610	COG0512	Glutamine amidotransferase of anthranilate synthase
D1605_RS04630	COG0084	hydrolase, TatD family'
D1605_RS04650	COG0552	protein localization to endoplasmic reticulum
D1605_RS04695	COG0824	Thioesterase
D1605_RS04720	COG2885	chlorophyll binding
D1605_RS04730	COG0602	queuosine metabolic process
D1605_RS04750	COG0386	Belongs to the glutathione peroxidase family
D1605_RS04770	COG0406	alpha-ribazole phosphatase activity
D1605_RS05000	COG0675	Transposase, IS605 OrfB family
D1605_RS05160	COG2369	cell adhesion
D1605_RS05195	COG3210	domain, Protein
D1605_RS05210	COG0582	viral genome integration into host DNA
D1605_RS05215	COG3567	Phage-associated protein, HI1409 family
D1605_RS05220	COG5410	chromosome segregation
D1605_RS05245	COG3772	lysozyme
D1605_RS05280	COG3617	BRO family, N-terminal domain
D1605_RS05365	COG5532	Uncharacterized conserved protein (DUF2303)
D1605_RS05395	COG0629	single-stranded DNA binding
D1605_RS05405	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
D1605_RS05410	COG3852	Histidine kinase
D1605_RS05415	COG2204	response regulator
D1605_RS05430	COG0004	ammonium transporteR
D1605_RS05435	COG0347	Belongs to the P(II) protein family
D1605_RS05440	COG0174	glutamine synthetase
D1605_RS05450	COG2353	YceI-like domain
D1605_RS05505	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
D1605_RS05510	COG1764	response to oxidative stress
D1605_RS05515	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D1605_RS05560	COG1399	metal-binding, possibly nucleic acid-binding protein
D1605_RS05570	COG0714	Associated with various cellular activities
D1605_RS05590	COG0537	adenosine 5'-monophosphoramidase activity
D1605_RS05605	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
D1605_RS05645	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D1605_RS05670	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
D1605_RS05670	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
D1605_RS05720	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
D1605_RS05735	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
D1605_RS05750	COG0251	oxidation-reduction process
D1605_RS05815	COG3077	Addiction module antitoxin, RelB DinJ family
D1605_RS05820	COG3041	Addiction module toxin RelE StbE family
D1605_RS05890	COG3772	lysozyme
D1605_RS05955	COG4197	protein conserved in bacteria, prophage-related
D1605_RS06025	COG3617	BRO family, N-terminal domain
D1605_RS06060	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
D1605_RS06065	COG0392	lysyltransferase activity
D1605_RS06065	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
D1605_RS06075	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D1605_RS06085	COG0463	Glycosyl transferase, family 2
D1605_RS06130	COG3275	phosphorelay sensor kinase activity
D1605_RS06135	COG0400	carboxylic ester hydrolase activity
D1605_RS06155	COG2226	methyltransferase
D1605_RS06180	COG2027	D-alanyl-D-alanine carboxypeptidase
D1605_RS06190	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D1605_RS06220	COG0386	Belongs to the glutathione peroxidase family
D1605_RS06225	COG1131	(ABC) transporter
D1605_RS06255	COG3657	addiction module killer protein
D1605_RS06260	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D1605_RS06365	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
D1605_RS06370	COG0488	(ABC) transporter
D1605_RS06380	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
D1605_RS06390	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
D1605_RS06390	COG4651	solute:proton antiporter activity
D1605_RS06450	COG0859	PFAM glycosyl transferase family 9
D1605_RS06465	COG0631	protein serine/threonine phosphatase activity
D1605_RS06470	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D1605_RS06500	COG2183	response to ionizing radiation
D1605_RS06515	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
D1605_RS06520	COG3118	belongs to the thioredoxin family
D1605_RS06565	COG2951	lytic endotransglycosylase activity
D1605_RS06570	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
D1605_RS06620	COG3210	domain, Protein
D1605_RS06655	COG0277	FAD linked oxidase domain protein
D1605_RS06660	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D1605_RS06665	COG0531	amino acid
D1605_RS06750	COG0460	homoserine dehydrogenase
D1605_RS06750	COG0527	aspartate kinase activity
D1605_RS06770	COG1686	Belongs to the peptidase S11 family
D1605_RS06795	COG4953	penicillin-binding protein 1C
D1605_RS06820	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D1605_RS06885	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D1605_RS06890	COG1506	peptidase
D1605_RS06890	COG0823	Involved in the tonB-independent uptake of proteins
D1605_RS06895	COG1297	OPT oligopeptide transporter protein
D1605_RS06925	COG0676	glucose-6-phosphate 1-epimerase activity
D1605_RS06935	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
D1605_RS06940	COG1335	isochorismatase
D1605_RS06945	COG0318	PFAM AMP-dependent synthetase and ligase
D1605_RS06955	COG0463	Glycosyl transferase, family 2
D1605_RS06970	COG1192	Involved in chromosome partitioning
D1605_RS07030	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
D1605_RS07075	COG0489	protein tyrosine kinase activity
D1605_RS07085	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D1605_RS07180	COG1605	Chorismate mutase
D1605_RS07180	COG0077	Prephenate dehydratase
D1605_RS07195	COG1668	transmembrane transport
D1605_RS07200	COG4555	ABC transporter
D1605_RS07225	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
D1605_RS07235	COG1605	Chorismate mutase
D1605_RS07235	COG0287	Prephenate dehydrogenase
D1605_RS07270	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D1605_RS07295	COG1278	Cold shock
D1605_RS07305	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
D1605_RS07315	COG2954	triphosphatase activity
D1605_RS07330	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
D1605_RS07335	COG0438	transferase activity, transferring glycosyl groups
D1605_RS07345	COG0438	transferase activity, transferring glycosyl groups
D1605_RS07410	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D1605_RS07415	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D1605_RS07430	COG1064	alcohol dehydrogenase
D1605_RS07445	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
D1605_RS07455	COG0436	Aminotransferase
D1605_RS07535	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D1605_RS07535	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
D1605_RS07585	COG0196	riboflavin kinase activity
D1605_RS07590	COG0728	peptidoglycan biosynthetic process
D1605_RS07595	COG0268	Binds directly to 16S ribosomal RNA
D1605_RS07645	COG1210	Utp--glucose-1-phosphate uridylyltransferase
D1605_RS07660	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
D1605_RS07715	COG0395	ABC-type sugar transport system, permease component
D1605_RS07720	COG1175	transmembrane transport
D1605_RS07750	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
D1605_RS07770	COG0436	Aminotransferase
D1605_RS07830	COG5434	Belongs to the glycosyl hydrolase 28 family
D1605_RS07855	COG0402	S-adenosylhomocysteine deaminase activity
D1605_RS07865	COG1509	lysine 2,3-aminomutase activity
D1605_RS07900	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
D1605_RS07905	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D1605_RS07920	COG1028	Short-chain dehydrogenase reductase Sdr
D1605_RS07970	COG0142	geranyltranstransferase activity
D1605_RS07995	COG1301	dicarboxylic acid transport
D1605_RS08005	COG0791	NLP P60 protein
D1605_RS08010	COG0791	NLP P60 protein
D1605_RS08020	COG2311	Membrane
D1605_RS08030	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
D1605_RS08090	COG0351	phosphomethylpyrimidine kinase
D1605_RS08090	COG0352	thiamine-phosphate diphosphorylase activity
D1605_RS08100	COG1324	tolerance protein
D1605_RS08135	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D1605_RS08140	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D1605_RS08145	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
D1605_RS08160	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D1605_RS08180	COG4774	siderophore transport
D1605_RS08205	COG1477	protein flavinylation
D1605_RS08210	COG1555	photosystem II stabilization
D1605_RS08215	COG3178	'Phosphotransferase
D1605_RS08220	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
D1605_RS08230	COG0628	permease
D1605_RS08245	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
D1605_RS08270	COG3590	peptidase
D1605_RS08320	COG0805	protein transport
D1605_RS08330	COG0519	Catalyzes the synthesis of GMP from XMP
D1605_RS08330	COG0518	GMP synthase (glutamine-hydrolyzing) activity
D1605_RS08340	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
D1605_RS08355	COG3107	peptidoglycan biosynthetic process
D1605_RS08380	COG2878	Part of a membrane complex involved in electron transport
D1605_RS08455	COG0629	single-stranded DNA binding
D1605_RS08480	COG0827	DNA restriction-modification system
D1605_RS08485	COG0827	DNA restriction-modification system
D1605_RS08525	COG4968	Prepilin-type N-terminal cleavage methylation domain
D1605_RS08530	COG1611	Belongs to the LOG family
D1605_RS08535	COG4943	cyclic-guanylate-specific phosphodiesterase activity
D1605_RS08540	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
D1605_RS08550	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D1605_RS08580	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D1605_RS08595	COG0330	HflC and HflK could
D1605_RS08600	COG0330	HflC and HflK could
D1605_RS08605	COG0604	alcohol dehydrogenase
D1605_RS08635	COG1183	phosphatidylcholine synthase activity
D1605_RS08655	COG0668	transmembrane transport
D1605_RS08660	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
D1605_RS08675	COG1610	YqeY-like protein
D1605_RS08685	COG0358	DNA primase activity
D1605_RS08725	COG1074	ATP-dependent DNA helicase activity
D1605_RS08730	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
D1605_RS08735	COG1127	ABC transporter
D1605_RS08740	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D1605_RS08760	COG2853	Lipoprotein
D1605_RS08770	COG1116	anion transmembrane transporter activity
D1605_RS08780	COG0531	amino acid
D1605_RS08785	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
D1605_RS08790	COG0861	Integral membrane protein TerC family
D1605_RS08825	COG2193	ferroxidase activity
D1605_RS08915	COG2194	sulfuric ester hydrolase activity
D1605_RS08955	COG0667	Aldo Keto reductase
D1605_RS08960	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D1605_RS08970	COG0305	Participates in initiation and elongation during chromosome replication
D1605_RS09010	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
D1605_RS09020	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D1605_RS09025	COG0277	FAD linked oxidase domain protein
D1605_RS09040	COG4206	TonB-dependent receptor
D1605_RS09140	COG3617	BRO family, N-terminal domain
D1605_RS09210	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
D1605_RS09230	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
D1605_RS09255	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D1605_RS09255	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D1605_RS09275	COG0488	(ABC) transporter
D1605_RS09285	COG3011	Protein conserved in bacteria
D1605_RS09315	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
D1605_RS09315	COG1918	ferrous iron import across plasma membrane
D1605_RS09325	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
D1605_RS09350	COG0758	DNA mediated transformation
D1605_RS09395	COG2969	positive regulation of protein catabolic process
D1605_RS09400	COG0625	glutathione transferase activity
D1605_RS09405	COG2857	Cytochrome c1
D1605_RS09410	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
D1605_RS09415	COG0723	plastoquinol--plastocyanin reductase activity
D1605_RS09420	COG0741	lytic transglycosylase activity
D1605_RS09430	COG1702	phosphate starvation-inducible protein PhoH
D1605_RS09445	COG4535	Mg2 and Co2 transporter CorC
D1605_RS09455	COG0598	Magnesium transport protein CorA
D1605_RS09490	COG3210	domain, Protein
D1605_RS09490	COG3210	domain, Protein
D1605_RS09510	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D1605_RS09520	COG1199	ATP-dependent helicase activity
D1605_RS09530	COG0288	reversible hydration of carbon dioxide
D1605_RS09555	COG2011	ABC-type metal ion transport system permease component
D1605_RS09575	COG0508	dehydrogenase complex catalyzes the overall conversion of
D1605_RS09580	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D1605_RS09595	COG0626	cystathionine gamma-synthase activity
D1605_RS09600	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D1605_RS09605	COG0739	heme binding
D1605_RS09625	COG1238	metal cluster binding
D1605_RS09640	COG5002	protein histidine kinase activity
D1605_RS09660	COG1388	LysM domain
D1605_RS09660	COG3858	chitin binding
D1605_RS09665	COG3525	Glycosyl hydrolase, family 20, catalytic domain
D1605_RS09675	COG1472	Belongs to the glycosyl hydrolase 3 family
D1605_RS09690	COG3537	Alpha-1,2-mannosidase
D1605_RS09715	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D1605_RS09720	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D1605_RS09765	COG0469	pyruvate kinase activity
D1605_RS09785	COG0735	belongs to the Fur family
D1605_RS09795	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
D1605_RS09795	COG5297	Belongs to the glycosyl hydrolase family 6
D1605_RS09825	COG4305	rare lipoprotein A
D1605_RS09835	COG0739	heme binding
D1605_RS09850	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
D1605_RS09860	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
D1605_RS09890	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
D1605_RS09905	COG3116	cell division
D1605_RS09920	COG0471	metal ion transport
D1605_RS09920	COG3273	potassium ion transport
D1605_RS09970	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D1605_RS10030	COG0860	N-Acetylmuramoyl-L-alanine amidase
D1605_RS10035	COG0802	atpase or kinase
D1605_RS10040	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
D1605_RS10040	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
D1605_RS10140	COG0745	RESPONSE REGULATOR receiver
D1605_RS10145	COG0642	Histidine kinase
D1605_RS10155	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
D1605_RS10200	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
D1605_RS10210	COG2831	hemolysin activation secretion protein
D1605_RS10235	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
D1605_RS10275	COG0316	Belongs to the HesB IscA family
D1605_RS10315	COG0697	spore germination
D1605_RS10320	COG0671	phosphoesterase, PA-phosphatase related
D1605_RS10335	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
D1605_RS10355	COG1132	(ABC) transporter
D1605_RS10360	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
D1605_RS10365	COG1538	Outer membrane efflux protein
D1605_RS10390	COG0745	RESPONSE REGULATOR receiver
D1605_RS10395	COG4783	chaperone-mediated protein folding
D1605_RS10405	COG0473	3-isopropylmalate dehydrogenase activity
D1605_RS10415	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D1605_RS10420	COG3083	sulfuric ester hydrolase activity
D1605_RS10425	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
D1605_RS10450	COG0564	pseudouridine synthase activity
D1605_RS10455	COG1530	ribonuclease E activity
D1605_RS10460	COG2197	response regulator
D1605_RS10475	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
D1605_RS10490	COG0488	(ABC) transporter
D1605_RS10505	COG1278	Cold shock
D1605_RS10605	COG0012	GTP binding
D1605_RS10695	COG2095	MarC family integral membrane protein
D1605_RS10705	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
D1605_RS10730	COG2132	Multicopper oxidase
D1605_RS10740	COG0210	DNA helicase
D1605_RS10750	COG0616	signal peptide processing
D1605_RS10770	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
D1605_RS10790	COG2201	protein-glutamate methylesterase activity
D1605_RS10795	COG2177	Part of the ABC transporter FtsEX involved in
D1605_RS10800	COG2884	Cell division ATP-binding protein ftsE
D1605_RS10810	COG3118	belongs to the thioredoxin family
D1605_RS10815	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
D1605_RS10830	COG0793	Belongs to the peptidase S41A family
D1605_RS10835	COG4942	peptidase
D1605_RS10850	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
D1605_RS10855	COG0493	'glutamate synthase
D1605_RS10860	COG0070	glutamate synthase
D1605_RS10860	COG0069	glutamate synthase activity
D1605_RS10860	COG0067	glutamate synthase
D1605_RS10910	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
D1605_RS10960	COG4942	peptidase
D1605_RS11105	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D1605_RS11110	COG3657	addiction module killer protein
D1605_RS11185	COG3210	domain, Protein
D1605_RS11255	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
D1605_RS11310	COG3451	type IV secretory pathway VirB4
D1605_RS11325	COG4962	Type ii secretion system protein e
D1605_RS11335	COG0629	single-stranded DNA binding
D1605_RS11355	COG0675	Transposase, IS605 OrfB family