locus-tag class description HKJ32_RS00005 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) HKJ32_RS00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HKJ32_RS00020 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HKJ32_RS00030 ENOG4108K0D peptidase, M48 HKJ32_RS00085 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HKJ32_RS00125 ENOG4105CGF Aromatic amino acid aminotransferase HKJ32_RS00145 ENOG4105D6S protein involved in catabolism of external DNA HKJ32_RS00155 ENOG4108JA2 transcriptioN-repair coupling factor HKJ32_RS00165 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein HKJ32_RS00170 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HKJ32_RS00175 ENOG4105C4R Atp-dependent dna helicase HKJ32_RS00205 ENOG4105D78 K07001 NTE family protein HKJ32_RS00245 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) HKJ32_RS00255 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY HKJ32_RS00280 ENOG4108VEV chaperone HKJ32_RS00285 ENOG4105X0I Fimbrial HKJ32_RS00290 ENOG4107TH8 cina domain protein HKJ32_RS00295 ENOG4105CSH Transporter HKJ32_RS00300 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HKJ32_RS00315 ENOG4105EEI dihydropteroate synthase HKJ32_RS00320 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HKJ32_RS00330 ENOG4105HBR Rna-binding protein HKJ32_RS00360 ENOG4105D1S lipid A biosynthesis HKJ32_RS00365 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase HKJ32_RS00385 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) HKJ32_RS00395 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HKJ32_RS00405 ENOG4105KUZ arsenate reductase HKJ32_RS00415 ENOG4105CAQ asparagine synthetase HKJ32_RS00425 ENOG4105EA8 2-Nitropropane dioxygenase HKJ32_RS00455 ENOG4105DGW oligopeptidase A HKJ32_RS00555 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase HKJ32_RS00565 ENOG4107QKV phosphomannomutase HKJ32_RS00605 ENOG4105EYM Major Facilitator superfamily HKJ32_RS00615 ENOG4105DR5 peptidase HKJ32_RS00650 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) HKJ32_RS00665 ENOG4105C2D reductase HKJ32_RS00675 ENOG4108UT2 hemolysin iii HKJ32_RS00685 ENOG4105EYA deoxyribonuclease HKJ32_RS00715 ENOG4107QX8 SPFH domain, Band 7 family protein HKJ32_RS00720 ENOG4105DXN mazG family HKJ32_RS00725 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase HKJ32_RS00730 ENOG4107RK2 ADP-ribose diphosphatase NudE HKJ32_RS00740 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) HKJ32_RS00745 ENOG4105C1J atp-dependent rna helicase HKJ32_RS00750 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase HKJ32_RS00770 ENOG4108J6E Pfam:Phage_integr_N HKJ32_RS00805 ENOG4105WXW Antirepressor HKJ32_RS00900 ENOG4105KUS lysozyme HKJ32_RS00970 ENOG41082AG Plasmid maintenance system antidote protein HKJ32_RS01050 ENOG4108YXA Membrane HKJ32_RS01080 ENOG4105CRQ synthase (Component I) HKJ32_RS01085 ENOG4105DDQ anthranilate synthase HKJ32_RS01115 ENOG4105DC7 peptidase M24 HKJ32_RS01135 ENOG4105VIE preprotein translocase, subunit YajC HKJ32_RS01140 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HKJ32_RS01145 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HKJ32_RS01155 ENOG4105DJ0 Poly(A) Polymerase HKJ32_RS01160 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase HKJ32_RS01195 ENOG4105CHV Transcription elongation factor NusA HKJ32_RS01230 ENOG4105ECR NmrA family HKJ32_RS01275 ENOG4105C10 Electron transfer flavoprotein HKJ32_RS01280 ENOG4105BZJ Electron transfer flavoprotein HKJ32_RS01295 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase HKJ32_RS01310 ENOG4107QKV phosphomannomutase HKJ32_RS01335 ENOG4105CBP Major Facilitator HKJ32_RS01355 ENOG4105DFU Cell wall formation (By similarity) HKJ32_RS01360 ENOG410841Q phosphoesterase PA-phosphatase related protein HKJ32_RS01375 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) HKJ32_RS01380 ENOG4105C02 permease HKJ32_RS01400 ENOG4105C0H protease HKJ32_RS01405 ENOG4105ECP epimerase HKJ32_RS01410 ENOG4105CEY Amp-dependent synthetase and ligase HKJ32_RS01415 ENOG4107QM5 aconitate hydratase HKJ32_RS01430 ENOG4107QIJ Aconitate hydratase 2 HKJ32_RS01480 ENOG410624X efflux transporter, rnd family, mfp subunit HKJ32_RS01505 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain HKJ32_RS01525 ENOG4105GKE subunit e HKJ32_RS01530 ENOG4107QIZ NADH dehydrogenase HKJ32_RS01535 ENOG4108IEH NADH dehydrogenase subunit g HKJ32_RS01550 ENOG4105DF2 NADH dehydrogenase subunit j HKJ32_RS01560 ENOG4105D65 subunit l HKJ32_RS01565 ENOG4105C8S subunit m HKJ32_RS01570 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HKJ32_RS01575 ENOG4105CHR reductase HKJ32_RS01580 ENOG4105D4T Citrate transporter HKJ32_RS01595 ENOG4105DHQ Histidine kinase HKJ32_RS01610 ENOG4105BZU Histidine kinase HKJ32_RS01630 ENOG4105C6K Malic enzyme HKJ32_RS01640 ENOG4106H78 methyltransferase HKJ32_RS01655 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding HKJ32_RS01665 ENOG4105BZU Histidine kinase HKJ32_RS01675 ENOG4105CD3 dihydroorotase HKJ32_RS01695 ENOG4105E8G Major facilitator Superfamily HKJ32_RS01700 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) HKJ32_RS01790 ENOG4108Z6B deaminase HKJ32_RS01795 ENOG4105KST dependent repressor HKJ32_RS01800 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) HKJ32_RS01815 ENOG4105C29 acyl-CoA thioesterase HKJ32_RS01885 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane HKJ32_RS01890 ENOG4105DZP Membrane-associated zinc metalloprotease HKJ32_RS01900 ENOG4105KNE Phosphatidate cytidylyltransferase HKJ32_RS01905 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) HKJ32_RS01935 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) HKJ32_RS01960 ENOG4108UHU Aldolase HKJ32_RS01965 ENOG4105C01 Dihydroxy-acid dehydratase HKJ32_RS01980 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase HKJ32_RS01990 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) HKJ32_RS02040 ENOG4108EC8 DNA internalization-related competence protein ComEC HKJ32_RS02130 ENOG4105VDM plasmid maintenance system antidote protein, xre family HKJ32_RS02200 ENOG4105KUS lysozyme HKJ32_RS02285 ENOG4107RZC phospholipase d HKJ32_RS02300 ENOG4105CS1 NAD(P)H quinone oxidoreductase HKJ32_RS02325 ENOG4105C2M dna polymerase I HKJ32_RS02355 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) HKJ32_RS02370 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase HKJ32_RS02375 ENOG4105BZU Histidine kinase HKJ32_RS02380 ENOG4105E39 Enoyl-CoA hydratase HKJ32_RS02385 ENOG4105CFH Aspartokinase HKJ32_RS02405 ENOG4105M6F mutator MutT protein HKJ32_RS02410 ENOG4105SYT Methylenetetrahydrofolate reductase HKJ32_RS02420 ENOG4108Z03 MAF-like protein HKJ32_RS02425 ENOG4105C03 ribonuclease HKJ32_RS02435 ENOG4105D1U peptidase U62 modulator of DNA gyrase HKJ32_RS02445 ENOG4105CMS peptidase U62, modulator of DNA gyrase HKJ32_RS02450 ENOG4105CC0 LysR family Transcriptional regulator HKJ32_RS02465 ENOG4105DQ4 alcohol dehydrogenase HKJ32_RS02515 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) HKJ32_RS02520 ENOG4107RAZ it plays a direct role in the translocation of protons across the membrane (By similarity) HKJ32_RS02575 ENOG41083MP 50s ribosomal protein l29 HKJ32_RS02635 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) HKJ32_RS02665 ENOG4105W0Z cytoplasmic protein HKJ32_RS02670 ENOG4105C0P Mg chelatase subunit ChlI HKJ32_RS02690 ENOG4107QQG Dehydrogenase HKJ32_RS02740 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) HKJ32_RS02750 ENOG4107QYD Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HKJ32_RS02755 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HKJ32_RS02770 ENOG4105I08 Pseudouridine synthase HKJ32_RS02775 ENOG4107URF beta-phospho-glucomutase HKJ32_RS02795 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) HKJ32_RS02800 ENOG4108K3A Glutathione S-transferase HKJ32_RS02810 ENOG4107XH4 PPIases accelerate the folding of proteins (By similarity) HKJ32_RS02815 ENOG4105CI3 gtp-binding protein typa HKJ32_RS02825 ENOG4108MBX Secretion Protein HKJ32_RS02850 ENOG4108JJA ABC, transporter HKJ32_RS02855 ENOG4105E3A (ABC) transporter HKJ32_RS02860 ENOG4105DA5 (ABC) transporter HKJ32_RS02880 ENOG4105CQ7 ATP-dependent helicase HKJ32_RS02905 ENOG4105CFU surface antigen HKJ32_RS02910 ENOG4105MA0 exported protein HKJ32_RS02915 ENOG4105CR4 methylisocitrate lyase HKJ32_RS02950 ENOG4108I0Z Aconitate hydratase HKJ32_RS02955 ENOG4105C7F AcnD-accessory protein PrpF HKJ32_RS03005 ENOG4105D64 Mechanosensitive ion channel HKJ32_RS03035 ENOG41065HY 1,4-beta-cellobiosidase HKJ32_RS03070 ENOG4106BRA Membrane HKJ32_RS03090 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HKJ32_RS03125 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) HKJ32_RS03130 ENOG4108DG9 Smr protein MutS2 HKJ32_RS03140 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase HKJ32_RS03155 ENOG4108SNX Mammalian cell entry related domain protein HKJ32_RS03160 ENOG4105DHJ ABC, transporter HKJ32_RS03200 ENOG4108UUM single-stranded DNA-binding protein HKJ32_RS03225 ENOG4108ZUW Major pilin subunit HKJ32_RS03340 ENOG4105D7V transposase HKJ32_RS03380 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) HKJ32_RS03390 ENOG4105CJN penicillin-binding protein HKJ32_RS03395 ENOG4105CNI cell division protein FtsW HKJ32_RS03405 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HKJ32_RS03425 ENOG4107QMS site-determining protein HKJ32_RS03460 ENOG4108YYC ycei family HKJ32_RS03465 ENOG4105BZU Histidine kinase HKJ32_RS03510 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein HKJ32_RS03515 ENOG4108I5D sulfate abc transporter HKJ32_RS03540 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HKJ32_RS03545 ENOG4105NTK Transcriptional repressor Mpra HKJ32_RS03575 ENOG4107U32 Beta-lactamase domain protein HKJ32_RS03585 ENOG4107SC1 transglycosylase HKJ32_RS03610 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HKJ32_RS03640 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) HKJ32_RS03645 ENOG4108M8W Monooxygenase HKJ32_RS03655 ENOG4105C9U ATP-dependent DNA helicase RecQ HKJ32_RS03665 ENOG4105CQ7 ATP-dependent helicase HKJ32_RS03675 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) HKJ32_RS03680 ENOG4105CCU oxidase (Subunit III) HKJ32_RS03685 ENOG4105BZ9 Cytochrome C oxidase, subunit I HKJ32_RS03690 ENOG4105E2S oxidase) subunit II HKJ32_RS03695 ENOG4105EAH synthase HKJ32_RS03700 ENOG4108UUM single-stranded DNA-binding protein HKJ32_RS03740 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HKJ32_RS03765 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA HKJ32_RS03770 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HKJ32_RS03775 ENOG4108IUZ ABC transporter HKJ32_RS03790 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase HKJ32_RS03795 ENOG4105C2X Arabinose 5-phosphate isomerase HKJ32_RS03835 ENOG4105T95 Thiol disulfide interChange protein HKJ32_RS03845 ENOG4105EYW Ion transport protein HKJ32_RS03860 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) HKJ32_RS03875 ENOG4108Z33 Thiol disulfide Interchange Protein HKJ32_RS03880 ENOG4108Z33 Thiol disulfide Interchange Protein HKJ32_RS03910 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HKJ32_RS03930 ENOG4105C3M thioredoxin reductase HKJ32_RS03950 ENOG4105D1H recombination factor protein RarA HKJ32_RS03960 ENOG4105BZU Histidine kinase HKJ32_RS03970 ENOG4105CAN Short-chain dehydrogenase reductase Sdr HKJ32_RS04000 ENOG4105ETE Transcriptional regulator (LacI family HKJ32_RS04005 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HKJ32_RS04010 ENOG4105CE4 GlcNAc 6-P deacetylase HKJ32_RS04015 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) HKJ32_RS04020 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) HKJ32_RS04025 ENOG4107BJW polysaccharide deacetylase HKJ32_RS04030 ENOG4107QPH glycogen) synthase HKJ32_RS04045 ENOG4105JRK feS assembly protein SufD HKJ32_RS04050 ENOG4105C3K feS assembly ATPase SufC HKJ32_RS04245 ENOG4105KUS lysozyme HKJ32_RS04350 ENOG4105WXW Antirepressor HKJ32_RS04390 ENOG4105CD8 aminopeptidase N HKJ32_RS04435 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) HKJ32_RS04460 ENOG4105DSJ YicC domain protein HKJ32_RS04475 ENOG4105CSA Coproporphyrinogen iii oxidase HKJ32_RS04515 ENOG4105EUR Domain-Containing protein HKJ32_RS04520 ENOG4107QHF type ii secretion system protein e HKJ32_RS04525 ENOG4105D7Q type ii secretion system HKJ32_RS04535 ENOG4105WMT general secretion pathway protein h HKJ32_RS04545 ENOG41069G9 General secretion pathway protein J HKJ32_RS04550 ENOG4105UV2 general secretion pathway protein K HKJ32_RS04555 ENOG41090VX general secretion pathway protein L HKJ32_RS04560 ENOG410678M general secretion pathway protein M HKJ32_RS04570 ENOG4105GVR general secretion pathway protein D HKJ32_RS04580 ENOG4105D3R alkyl hydroperoxide reductase HKJ32_RS04590 ENOG4105C5Q Transcriptional regulator HKJ32_RS04595 ENOG41072GX Peptidase M22 Glycoprotease HKJ32_RS04605 ENOG4105BZN citrate synthase HKJ32_RS04655 ENOG4105CUZ uba thif-type nad fad binding protein HKJ32_RS04675 ENOG4105C7S Dehydrogenase HKJ32_RS04680 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 HKJ32_RS04685 ENOG4105EZE Cupin 4 family protein HKJ32_RS04690 ENOG4107QTF adenylosuccinate lyase HKJ32_RS04795 ENOG4105KUS lysozyme HKJ32_RS04875 ENOG4105BZS acriflavin resistance protein HKJ32_RS04880 ENOG4105C1P efflux transporter, rnd family, mfp subunit HKJ32_RS04885 ENOG4105C7I Dehydrogenase HKJ32_RS04925 ENOG4105CHR reductase HKJ32_RS04955 ENOG4105D17 glycoside hydrolase, family 3 domain protein HKJ32_RS04975 ENOG4105CJB Exodeoxyribonuclease I HKJ32_RS04985 ENOG4105EEQ Na H antiporter HKJ32_RS05005 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase HKJ32_RS05015 ENOG4105W8B Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) HKJ32_RS05030 ENOG4107RAQ aminopeptidase HKJ32_RS05040 ENOG41069NU Nitroreductase HKJ32_RS05075 ENOG4105CM2 brancheD-chain amino acid aminotransferase HKJ32_RS05100 ENOG4106WTF Glycosyl transferase, family 2 HKJ32_RS05110 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) HKJ32_RS05125 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) HKJ32_RS05135 ENOG4108Z0R Transferase HKJ32_RS05150 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) HKJ32_RS05155 ENOG4105EM2 membrane HKJ32_RS05180 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) HKJ32_RS05190 ENOG4105E2T synthase III HKJ32_RS05205 ENOG4108J2P Alpha beta hydrolase fold HKJ32_RS05210 ENOG4105PI0 Ferredoxin HKJ32_RS05215 ENOG4105C4K Nad synthetase HKJ32_RS05245 ENOG4108UNF response regulator HKJ32_RS05250 ENOG4108ZGA chew protein HKJ32_RS05255 ENOG4105C8Q Methyl-accepting chemotaxis HKJ32_RS05275 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase HKJ32_RS05290 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase HKJ32_RS05300 ENOG4105DGW oligopeptidase A HKJ32_RS05320 ENOG4105CK2 sodium dicarboxylate symporter HKJ32_RS05325 ENOG4105CV1 Transketolase (EC 2.2.1.1) HKJ32_RS05355 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase HKJ32_RS05370 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HKJ32_RS05400 ENOG4105F8V Hydrolase, tatD family HKJ32_RS05415 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) HKJ32_RS05420 ENOG4105CEN a g-specific adenine glycosylase HKJ32_RS05460 ENOG4107YD3 Thioesterase HKJ32_RS05465 ENOG4105E02 MotA TolQ exbB proton channel HKJ32_RS05470 ENOG4105SG9 biopolymer transport protein, ExbD HKJ32_RS05485 ENOG4105KCK Peptidoglycan-associated lipoprotein HKJ32_RS05495 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) HKJ32_RS05510 ENOG4105DUX Transporter HKJ32_RS05515 ENOG4108V06 Glutathione peroxidase HKJ32_RS05520 ENOG4105DP0 ferredoxin-NADP reductase HKJ32_RS05535 ENOG4105CVJ phosphoglycerate mutase HKJ32_RS05595 ENOG4108KU3 Integrase HKJ32_RS05610 ENOG4108UUM single-stranded DNA-binding protein HKJ32_RS05630 ENOG4108HJ1 Uncharacterized conserved protein (DUF2303) HKJ32_RS05635 ENOG4105H40 HKJ32_RS05715 ENOG4105WXW Antirepressor HKJ32_RS05745 ENOG4105KUS lysozyme HKJ32_RS05780 ENOG4108C66 Inherit from COG: DNA primase HKJ32_RS05815 ENOG4106GMR HKJ32_RS05875 ENOG4105YES addiction module antidote protein HKJ32_RS05880 ENOG4105VUH addiction module killer protein HKJ32_RS05985 ENOG4108KU3 Integrase HKJ32_RS06145 ENOG4107GFK fumarate HKJ32_RS06180 ENOG4105CUX Signal transduction histidine kinase HKJ32_RS06185 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HKJ32_RS06200 ENOG4105BZU Histidine kinase HKJ32_RS06210 ENOG4105C5F glutamine synthetase HKJ32_RS06215 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) HKJ32_RS06220 ENOG4108YYC ycei family HKJ32_RS06325 ENOG4105KUS lysozyme HKJ32_RS06425 ENOG4105WXW Antirepressor HKJ32_RS06455 ENOG4108J6E Pfam:Phage_integr_N HKJ32_RS06505 ENOG4105D6Z AFG1 family ATPase HKJ32_RS06510 ENOG4108ZHJ Organic hydroperoxide resistance protein HKJ32_RS06515 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase HKJ32_RS06520 ENOG4105CN1 protease HKJ32_RS06525 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase HKJ32_RS06540 ENOG4105C7B Threonine dehydratase HKJ32_RS06550 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HKJ32_RS06560 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein HKJ32_RS06570 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HKJ32_RS06580 ENOG4105F8C transglutaminase domain-containing protein HKJ32_RS06590 ENOG4105K59 histidine triad (HIT) protein HKJ32_RS06605 ENOG4107QMP dna polymerase iii subunits gamma and tau HKJ32_RS06645 ENOG4107YZP Rhodanese domain protein HKJ32_RS06670 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase HKJ32_RS06675 ENOG4108194 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) HKJ32_RS06695 ENOG4108ZUW Major pilin subunit HKJ32_RS06710 ENOG4105DFA alanine racemase domain protein HKJ32_RS06715 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) HKJ32_RS06725 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) HKJ32_RS06740 ENOG4105M4H endoribonuclease L-psp HKJ32_RS06755 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HKJ32_RS06765 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) HKJ32_RS06780 ENOG4105CZX twitching motility protein HKJ32_RS06785 ENOG4105CZX twitching motility protein HKJ32_RS06805 ENOG4108NEV two component transcriptional regulator, LytTR family HKJ32_RS06810 ENOG4108HRK Histidine kinase HKJ32_RS06815 ENOG4106CJB Phospholipase Carboxylesterase HKJ32_RS06835 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HKJ32_RS06845 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family HKJ32_RS06860 ENOG4105D7K pfkb domain protein HKJ32_RS06880 ENOG4105C6Y Udp-glucose 6-dehydrogenase HKJ32_RS06900 ENOG4105CZV ABC transporter HKJ32_RS06955 ENOG4105VUH addiction module killer protein HKJ32_RS06960 ENOG4105YES addiction module antidote protein HKJ32_RS06990 ENOG4106GMR HKJ32_RS07025 ENOG4108C66 Inherit from COG: DNA primase HKJ32_RS07030 ENOG4107ZQ5 Phage-associated protein, HI1409 family HKJ32_RS07060 ENOG4105KUS lysozyme HKJ32_RS07100 ENOG4105D52 delta-aminolevulinic acid dehydratase HKJ32_RS07105 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase HKJ32_RS07125 ENOG4105D1F ATP-binding protein HKJ32_RS07195 ENOG4105C5H ABC transporter HKJ32_RS07200 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) HKJ32_RS07210 ENOG4107RNH Outer membrane receptor FepA HKJ32_RS07215 ENOG4105CKD glutathione-regulated potassium-efflux system protein HKJ32_RS07275 ENOG4105DKP glycosyl transferase, family 9 HKJ32_RS07290 ENOG4108ZF3 Phosphatase HKJ32_RS07295 ENOG4107RZZ dna polymerase iii epsilon subunit HKJ32_RS07300 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HKJ32_RS07325 ENOG4105BZM domain protein HKJ32_RS07340 ENOG4105F0N pyrophosphate phospho-hydrolase HKJ32_RS07345 ENOG4105K63 Thioredoxin HKJ32_RS07395 ENOG4105CVE Lytic murein transglycosylase HKJ32_RS07400 ENOG4105K6T rare lipoprotein A HKJ32_RS07510 ENOG4105CQB FAD linked oxidase domain protein HKJ32_RS07515 ENOG4108JQ1 Dehydrogenase HKJ32_RS07520 ENOG4105CUB amino acid HKJ32_RS07525 ENOG4105CUB amino acid HKJ32_RS07610 ENOG4105CFH Aspartokinase HKJ32_RS07615 ENOG4105CXT aspartate transcarbamylase HKJ32_RS07630 ENOG4105DZ1 carboxypeptidase HKJ32_RS07655 ENOG4108JQB penicillin-binding protein 1C HKJ32_RS07665 ENOG4105EMN RNA polymerase sigma factor HKJ32_RS07675 ENOG4105C0H protease HKJ32_RS07685 ENOG4105C3F Signal peptidase i HKJ32_RS07745 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein HKJ32_RS07750 ENOG4105EPD Oligopeptide transporter, Opt family HKJ32_RS07760 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HKJ32_RS07765 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HKJ32_RS07780 ENOG4105DSB aldose 1-epimerase HKJ32_RS07790 ENOG4105WPN DNA integration recombination invertion protein HKJ32_RS07795 ENOG4108RWI nicotinamidase HKJ32_RS07800 ENOG410680H amp-dependent synthetase and ligase HKJ32_RS07825 ENOG4107QJE Chromosome Partitioning Protein HKJ32_RS07885 ENOG4105KUS lysozyme HKJ32_RS07955 ENOG4108SDH ABC, transporter HKJ32_RS07960 ENOG4108IUW ABC transporter HKJ32_RS07985 ENOG41080IJ Diacylglycerol kinase HKJ32_RS08025 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) HKJ32_RS08030 ENOG41090R7 Ferric uptake HKJ32_RS08035 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HKJ32_RS08060 ENOG4105VEQ Cold shock protein HKJ32_RS08070 ENOG4108UGV hypoxanthine phosphoribosyltransferase HKJ32_RS08090 ENOG4105EFQ Two component transcriptional regulator (Winged helix family HKJ32_RS08095 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family HKJ32_RS08100 ENOG4108NQK Catalyzes the transfer of a glucuronic acid (GlcA) residue from UDP-glucuronate to mannose-alpha-1,3-glucose-beta- 1,4-glucose-P-P-polyisoprenyl to form the lipid-linked tetrasaccharide GlcA-Man-Glc(2)-PP-Pol, with a glucuronic acid- beta-mannose linkage. Is involved in the biosynthesis of the exopolysaccharide xanthan, since it catalyzes the fourth glycosylation step in the assembly of the pentasaccharide-P-P- polyisoprenyl repeating unit of xanthan. Is unable to use the trisaccharide acceptor freed from the pyrophosphate lipid moiety. Does not show specificity for the lipidic portion of the acceptor. Shows diminished activity when tested with 6-O-acetyl-mannose- alpha-1,3-glucose-beta-1,4-glucose-P-P-polyisoprenyl, a HKJ32_RS08110 ENOG4107UFF group 1 glycosyl transferase HKJ32_RS08125 ENOG4105D3Q Sugar transferase HKJ32_RS08170 ENOG4105ENT Efflux transporter rnd family, mfp subunit HKJ32_RS08175 ENOG4105BZS acriflavin resistance protein HKJ32_RS08190 ENOG4105DQ4 alcohol dehydrogenase HKJ32_RS08235 ENOG4105X54 addiction module antidote protein HKJ32_RS08245 ENOG4108C33 Resolvase HKJ32_RS08250 ENOG4105D7V transposase HKJ32_RS08260 ENOG4105CHM Aminotransferase HKJ32_RS08265 ENOG4108JJA ABC, transporter HKJ32_RS08270 ENOG4105C42 Type I secretion membrane fusion protein (HlyD HKJ32_RS08325 ENOG4105DTN riboflavin biosynthesis protein ribF HKJ32_RS08330 ENOG4105CJR Integral membrane protein (MviN HKJ32_RS08335 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) HKJ32_RS08355 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HKJ32_RS08370 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HKJ32_RS08375 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) HKJ32_RS08380 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HKJ32_RS08395 ENOG4105CFV Tetratricopeptide repeat protein HKJ32_RS08405 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) HKJ32_RS08410 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) HKJ32_RS08430 ENOG4105DWY Agmatine deiminase HKJ32_RS08450 ENOG4105DRS transport system, permease HKJ32_RS08455 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component HKJ32_RS08480 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) HKJ32_RS08505 ENOG4105CHM Aminotransferase HKJ32_RS08510 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) HKJ32_RS08515 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) HKJ32_RS08520 ENOG41060IM Heme exporter protein HKJ32_RS08530 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) HKJ32_RS08535 ENOG4105DA4 cytochrome c-type biogenesis protein HKJ32_RS08540 ENOG4107QX9 Thiol disulfide interChange protein HKJ32_RS08545 ENOG4105KWW Biogenesis protein HKJ32_RS08595 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) HKJ32_RS08605 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein HKJ32_RS08635 ENOG4107QRG dna polymerase iii HKJ32_RS08640 ENOG4105HHA aminodeoxychorismate lyase HKJ32_RS08650 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HKJ32_RS08660 ENOG4105CHR reductase HKJ32_RS08665 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HKJ32_RS08670 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) HKJ32_RS08675 ENOG4105DDI hemolysin-type calcium-binding region HKJ32_RS08705 ENOG4105CTB Polyprenyl synthetase HKJ32_RS08715 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) HKJ32_RS08740 ENOG4105K4H Nlp p60 protein HKJ32_RS08745 ENOG4105K4H Nlp p60 protein HKJ32_RS08750 ENOG4108YZY peptidylprolyl cis-trans isomerase HKJ32_RS08770 ENOG4105CSM endonuclease III HKJ32_RS08780 ENOG4108V1T peptidylprolyl cis-trans isomerase HKJ32_RS08895 ENOG4105DWF phosphomethylpyrimidine kinase HKJ32_RS08900 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) HKJ32_RS08905 ENOG4105VF7 tolerance protein HKJ32_RS08940 ENOG4108IAJ Nad-dependent epimerase dehydratase HKJ32_RS08945 ENOG4107TXM Nad-dependent epimerase dehydratase HKJ32_RS08950 ENOG4105C0K Gdp-mannose 4,6-dehydratase HKJ32_RS08965 ENOG4105C6T cysteine synthase HKJ32_RS08985 ENOG4108IU3 tonb-dependent siderophore receptor HKJ32_RS09010 ENOG4105CJ2 (LipO)protein HKJ32_RS09015 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein HKJ32_RS09020 ENOG4105EHM Aminoglycoside phosphotransferase HKJ32_RS09025 ENOG4108S0S Nucleotidyl transferase HKJ32_RS09035 ENOG4105C02 permease HKJ32_RS09045 ENOG4105CXB phosphoribosylaminoimidazole synthetase HKJ32_RS09050 ENOG4108V3E phosphoribosylglycinamide formyltransferase HKJ32_RS09075 ENOG4105C9K Endothelin-converting enzyme 1 HKJ32_RS09130 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HKJ32_RS09145 ENOG41090JD Blue (Type 1) copper domain protein HKJ32_RS09160 ENOG4105E1C Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity) HKJ32_RS09170 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) HKJ32_RS09180 ENOG4108R3D Electron transport complex HKJ32_RS09230 ENOG4107R5S dna adenine HKJ32_RS09285 ENOG4105EWT decarboxylase family HKJ32_RS09290 ENOG4108M8H domain protein HKJ32_RS09295 ENOG4105D06 uba thif-type nad fad binding protein HKJ32_RS09305 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HKJ32_RS09335 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HKJ32_RS09350 ENOG4105EPW hflc protein HKJ32_RS09355 ENOG4107QJR hflk protein HKJ32_RS09365 ENOG4105M3Z response regulator HKJ32_RS09390 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase HKJ32_RS09405 ENOG4107QK4 glycoside hydrolase, family 3 domain protein HKJ32_RS09410 ENOG4105CUY Mechanosensitive ion channel HKJ32_RS09415 ENOG4107ZVW dihydroneopterin aldolase HKJ32_RS09430 ENOG4105KTH gatB Yqey HKJ32_RS09440 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) HKJ32_RS09475 ENOG4107QKA exodeoxyribonuclease V beta HKJ32_RS09480 ENOG4105DSY exodeoxyribonuclease V, gamma HKJ32_RS09485 ENOG4105DHJ ABC, transporter HKJ32_RS09490 ENOG4105CY3 ABC transporter, permease HKJ32_RS09510 ENOG410903C (LipO)protein HKJ32_RS09515 ENOG4107QSV RmuC domain protein HKJ32_RS09530 ENOG4105CUB amino acid HKJ32_RS09535 ENOG4105DR4 Methyltransferase HKJ32_RS09540 ENOG4105DU1 integral membrane protein, terc HKJ32_RS09580 ENOG4108UQY Iron-storage protein HKJ32_RS09610 ENOG4105IFJ Histidine kinase HKJ32_RS09615 ENOG4105XJC Two component transcriptional regulator (Winged helix family HKJ32_RS09625 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HKJ32_RS09730 ENOG4105KUS lysozyme HKJ32_RS09745 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HKJ32_RS09775 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) HKJ32_RS09795 ENOG4105W7J DNA binding HKJ32_RS09800 ENOG410649Z repressor HKJ32_RS09870 ENOG4108ZUW Major pilin subunit HKJ32_RS09900 ENOG4105UGU tonB-dependent Receptor HKJ32_RS09915 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HKJ32_RS09930 ENOG4106A3M Cytochrome p-450 HKJ32_RS09935 ENOG4105DIJ Phosphoethanolamine transferase HKJ32_RS09975 ENOG4105CPC Aldo Keto reductase HKJ32_RS09980 ENOG4108RVA ribokinase HKJ32_RS09985 ENOG4105CDV Ompa motb domain protein HKJ32_RS09990 ENOG4105CDU Replicative dna helicase HKJ32_RS10010 ENOG4105CB5 ATP-dependent DNA helicase recG HKJ32_RS10015 ENOG4105KME endoribonuclease L-psp HKJ32_RS10020 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HKJ32_RS10025 ENOG4105CQB FAD linked oxidase domain protein HKJ32_RS10030 ENOG4105CDV Ompa motb domain protein HKJ32_RS10035 ENOG41080I0 Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) HKJ32_RS10040 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) HKJ32_RS10120 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HKJ32_RS10140 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) HKJ32_RS10155 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) HKJ32_RS10170 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) HKJ32_RS10190 ENOG4105C5H ABC transporter HKJ32_RS10200 ENOG4105KIR Thiol-disulfide oxidoreductase dcc HKJ32_RS10210 ENOG4105C34 Pseudouridine synthase HKJ32_RS10225 ENOG4105CE1 Ferrous iron transport protein b HKJ32_RS10235 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) HKJ32_RS10260 ENOG4105C79 DNA protecting protein DprA HKJ32_RS10305 ENOG4105KB2 stringent starvation protein b HKJ32_RS10310 ENOG4107MKT Stringent starvation protein a HKJ32_RS10315 ENOG4105EIX cytochrome c1 HKJ32_RS10320 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) HKJ32_RS10325 ENOG4108R5F Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) HKJ32_RS10330 ENOG4105E4C Lytic transglycosylase catalytic HKJ32_RS10340 ENOG4105C9A Phoh family HKJ32_RS10355 ENOG4108JU5 Magnesium and cobalt efflux protein HKJ32_RS10365 ENOG4105D7N magnesium and cobalt transport protein CorA HKJ32_RS10430 ENOG4105BZ4 penicillin-binding protein HKJ32_RS10440 ENOG4105DVT helicase HKJ32_RS10450 ENOG41077A9 carbonic anhydrase HKJ32_RS10475 ENOG4108UMI ABC transporter, permease HKJ32_RS10480 ENOG4105D01 (LipO)protein HKJ32_RS10495 ENOG4107QSN dihydrolipoamide acetyltransferase HKJ32_RS10500 ENOG4107QN2 dihydrolipoyl dehydrogenase HKJ32_RS10515 ENOG4105C28 cystathionine HKJ32_RS10520 ENOG4106TYC homoserine o-acetyltransferase (EC 2.3.1.31) HKJ32_RS10525 ENOG4105DR5 peptidase HKJ32_RS10550 ENOG4108UM1 dedA family HKJ32_RS10555 ENOG4108K5P (LipO)protein HKJ32_RS10565 ENOG4105BZU Histidine kinase HKJ32_RS10585 ENOG4105VRS hydrolase family 18 HKJ32_RS10590 ENOG4105E2D ec 3.2.1.52 HKJ32_RS10615 ENOG4105CWX Alpha-1,2-mannosidase HKJ32_RS10645 ENOG4105D0A hydroxylase HKJ32_RS10655 ENOG4107R11 Transcriptional regulator HKJ32_RS10695 ENOG4105CA9 Pyruvate kinase HKJ32_RS10715 ENOG4105MYN Zinc uptake regulation protein HKJ32_RS10725 ENOG4106R7G Glycoside hydrolase family 5 HKJ32_RS10755 ENOG4108YQE rare lipoprotein a HKJ32_RS10765 ENOG4105DR5 peptidase HKJ32_RS10775 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HKJ32_RS10780 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) HKJ32_RS10785 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) HKJ32_RS10790 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) HKJ32_RS10820 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) HKJ32_RS10830 ENOG4105CJN penicillin-binding protein HKJ32_RS10835 ENOG4106932 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) HKJ32_RS10865 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) HKJ32_RS10905 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) HKJ32_RS10950 ENOG4108VCT Sulfite exporter TauE/SafE HKJ32_RS10970 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HKJ32_RS10975 ENOG4105K8N protein family UPF0079, ATPase HKJ32_RS10980 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) HKJ32_RS10985 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HKJ32_RS11050 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) HKJ32_RS11075 ENOG4105ETX regulatoR HKJ32_RS11090 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) HKJ32_RS11115 ENOG4107QHF type ii secretion system protein e HKJ32_RS11120 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HKJ32_RS11125 ENOG4107TUY Histidine kinase HKJ32_RS11135 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha HKJ32_RS11145 ENOG4105D5K Hemolysin activator protein HKJ32_RS11155 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HKJ32_RS11170 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) HKJ32_RS11210 ENOG4108Z4V iron-sulfur cluster assembly HKJ32_RS11245 ENOG4108SXK Transporter Drug Metabolite Exporter family HKJ32_RS11250 ENOG410841Q phosphoesterase PA-phosphatase related protein HKJ32_RS11255 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) HKJ32_RS11265 ENOG4108UYB regulatoR HKJ32_RS11270 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) HKJ32_RS11285 ENOG4105BZ1 (ABC) transporter HKJ32_RS11290 ENOG4108KE4 O-methyltransferase HKJ32_RS11295 ENOG4105DFG type I secretion outer membrane protein HKJ32_RS11310 ENOG4105C9X ppx gppa phosphatase HKJ32_RS11320 ENOG4105BZU Histidine kinase HKJ32_RS11325 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HKJ32_RS11330 ENOG4105ERG peptidase m48, ste24p HKJ32_RS11335 ENOG4105VW4 glutaredoxin 3 HKJ32_RS11340 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HKJ32_RS11350 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HKJ32_RS11355 ENOG4105E68 Sulfatase HKJ32_RS11360 ENOG4108Z4U Ferredoxin HKJ32_RS11385 ENOG4105EI2 Pseudouridine synthase HKJ32_RS11390 ENOG4105C03 ribonuclease HKJ32_RS11410 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HKJ32_RS11425 ENOG4105C5H ABC transporter HKJ32_RS11455 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) HKJ32_RS11500 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) HKJ32_RS11505 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) HKJ32_RS11510 ENOG4105PM1 preprotein translocase subunit SecE HKJ32_RS11520 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) HKJ32_RS11540 ENOG4105C3G gtp-binding protein HKJ32_RS11555 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HKJ32_RS11575 ENOG4105DJQ tetratricopeptide tpr_2 repeat protein HKJ32_RS11630 ENOG41076UM multiple antibiotic resistance (MarC)-related protein HKJ32_RS11635 ENOG4105M2J Glutaredoxin HKJ32_RS11640 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit HKJ32_RS11645 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) HKJ32_RS11660 ENOG4107STQ Multicopper oxidase HKJ32_RS11670 ENOG4105C4R Atp-dependent dna helicase HKJ32_RS11680 ENOG4105D07 Signal peptide peptidase, SppA HKJ32_RS11700 ENOG4105C25 Primosomal protein n' HKJ32_RS11715 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) HKJ32_RS11720 ENOG4105CRP Part of the ABC transporter FtsEX involved in HKJ32_RS11725 ENOG4105CAK Cell division ATP-binding protein ftsE HKJ32_RS11730 ENOG4105C1J atp-dependent rna helicase HKJ32_RS11740 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) HKJ32_RS11745 ENOG4105E9K Isocitrate dehydrogenase HKJ32_RS11755 ENOG4105CN1 protease HKJ32_RS11760 ENOG41063SB peptidase HKJ32_RS11780 ENOG4105BZ8 glutamate synthase HKJ32_RS11785 ENOG4105CBC glutamate synthase HKJ32_RS11790 ENOG4105II7 pyrroline-5-carboxylate reductase HKJ32_RS11830 ENOG4105DZR Type I site-specific deoxyribonuclease HKJ32_RS11875 ENOG410829K Lysine exporter protein (Lyse ygga) HKJ32_RS11890 ENOG4105E7D Protein of unknown function (DUF3375) HKJ32_RS11925 ENOG4105DZR Type I site-specific deoxyribonuclease HKJ32_RS11940 ENOG4105CVR type I restriction-modification system HKJ32_RS12135 ENOG4107FTS RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)