locus-tag	class	description
HKJ33_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HKJ33_RS00020	COG0187	DNA topoisomerase II activity
HKJ33_RS00030	COG0501	Belongs to the peptidase M48B family
HKJ33_RS00090	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HKJ33_RS00150	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HKJ33_RS00160	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HKJ33_RS00170	COG0511	ligase activity, forming carbon-carbon bonds
HKJ33_RS00175	COG0439	Biotin carboxylase
HKJ33_RS00180	COG0210	DNA helicase
HKJ33_RS00210	COG1752	Esterase of the alpha-beta hydrolase superfamily
HKJ33_RS00250	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HKJ33_RS00260	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HKJ33_RS00285	COG3121	Chaperone
HKJ33_RS00290	COG3539	Fimbrial protein
HKJ33_RS00295	COG1546	Belongs to the CinA family
HKJ33_RS00300	COG0477	Major facilitator Superfamily
HKJ33_RS00305	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HKJ33_RS00320	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HKJ33_RS00325	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HKJ33_RS00335	COG1534	Rna-binding protein
HKJ33_RS00365	COG1560	Kdo2-lipid A biosynthetic process
HKJ33_RS00370	COG1519	Transferase
HKJ33_RS00390	COG0336	Belongs to the RNA methyltransferase TrmD family
HKJ33_RS00410	COG1393	Belongs to the ArsC family
HKJ33_RS00420	COG0367	asparagine synthase
HKJ33_RS00430	COG2070	2-Nitropropane dioxygenase
HKJ33_RS00460	COG0339	signal peptide processing
HKJ33_RS00545	COG4221	oxidoreductase activity
HKJ33_RS00565	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HKJ33_RS00575	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HKJ33_RS00615	COG2223	nitrite transmembrane transporter activity
HKJ33_RS00625	COG0739	heme binding
HKJ33_RS00675	COG1028	Short-chain dehydrogenase reductase Sdr
HKJ33_RS00685	COG1272	protein, Hemolysin III
HKJ33_RS00690	COG0463	Glycosyl transferase, family 2
HKJ33_RS00695	COG0084	hydrolase, TatD family'
HKJ33_RS00725	COG0330	HflC and HflK could
HKJ33_RS00730	COG3956	TIGRFAM MazG family protein
HKJ33_RS00740	COG0494	nUDIX hydrolase
HKJ33_RS00750	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HKJ33_RS00755	COG0513	Belongs to the DEAD box helicase family
HKJ33_RS00760	COG0720	synthase
HKJ33_RS00780	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HKJ33_RS00815	COG3617	BRO family, N-terminal domain
HKJ33_RS00910	COG3772	lysozyme
HKJ33_RS00980	COG3093	addiction module antidote protein HigA
HKJ33_RS01095	COG0512	Glutamine amidotransferase of anthranilate synthase
HKJ33_RS01125	COG0006	proline dipeptidase activity
HKJ33_RS01145	COG1862	Preprotein translocase
HKJ33_RS01150	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HKJ33_RS01155	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HKJ33_RS01165	COG0617	tRNA 3'-terminal CCA addition
HKJ33_RS01205	COG0195	Participates in both transcription termination and antitermination
HKJ33_RS01235	COG1733	regulation of RNA biosynthetic process
HKJ33_RS01240	COG0702	epimerase
HKJ33_RS01285	COG2086	electron transfer activity
HKJ33_RS01315	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HKJ33_RS01340	COG0477	Major facilitator Superfamily
HKJ33_RS01360	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HKJ33_RS01365	COG0671	phosphoesterase, PA-phosphatase related
HKJ33_RS01380	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HKJ33_RS01385	COG0628	permease
HKJ33_RS01405	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HKJ33_RS01410	COG1090	epimerase
HKJ33_RS01415	COG0318	PFAM AMP-dependent synthetase and ligase
HKJ33_RS01435	COG1049	propionate catabolic process, 2-methylcitrate cycle
HKJ33_RS01480	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HKJ33_RS01505	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HKJ33_RS01525	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
HKJ33_RS01530	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HKJ33_RS01535	COG1034	ATP synthesis coupled electron transport
HKJ33_RS01570	COG1007	ATP synthesis coupled electron transport
HKJ33_RS01575	COG1028	Short-chain dehydrogenase reductase Sdr
HKJ33_RS01580	COG2851	Citrate transporter
HKJ33_RS01595	COG0642	Histidine kinase
HKJ33_RS01610	COG0784	Response regulator, receiver
HKJ33_RS01610	COG2205	protein histidine kinase activity
HKJ33_RS01630	COG0280	phosphate acetyltransferase
HKJ33_RS01630	COG0281	malic enzyme
HKJ33_RS01640	COG0742	ribosomal rna small subunit methyltransferase
HKJ33_RS01655	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HKJ33_RS01665	COG3706	GGDEF domain
HKJ33_RS01675	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HKJ33_RS01700	COG2166	iron-sulfur cluster assembly
HKJ33_RS01730	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HKJ33_RS01800	COG1914	H( )-stimulated, divalent metal cation uptake system
HKJ33_RS01815	COG1946	Acyl-CoA thioesterase
HKJ33_RS01890	COG0750	zinc metalloprotease
HKJ33_RS01900	COG0575	Belongs to the CDS family
HKJ33_RS01905	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HKJ33_RS01935	COG0528	UMP kinase activity
HKJ33_RS01980	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HKJ33_RS01990	COG0354	folic acid binding
HKJ33_RS02000	COG2009	succinate dehydrogenase
HKJ33_RS02005	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HKJ33_RS02015	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HKJ33_RS02045	COG0811	peptide transport
HKJ33_RS02120	COG3077	Addiction module antitoxin, RelB DinJ family
HKJ33_RS02195	COG3772	lysozyme
HKJ33_RS02270	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HKJ33_RS02315	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HKJ33_RS02315	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HKJ33_RS02345	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HKJ33_RS02370	COG1024	Enoyl-CoA hydratase
HKJ33_RS02375	COG0527	aspartate kinase activity
HKJ33_RS02395	COG0494	nUDIX hydrolase
HKJ33_RS02400	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HKJ33_RS02410	COG0424	maF-like protein
HKJ33_RS02415	COG1530	ribonuclease E activity
HKJ33_RS02425	COG0312	modulator of DNA gyrase
HKJ33_RS02435	COG0312	modulator of DNA gyrase
HKJ33_RS02440	COG0583	DNA-binding transcription factor activity
HKJ33_RS02455	COG1064	alcohol dehydrogenase
HKJ33_RS02510	COG0356	it plays a direct role in the translocation of protons across the membrane
HKJ33_RS02565	COG0255	Belongs to the universal ribosomal protein uL29 family
HKJ33_RS02625	COG0201	protein transport
HKJ33_RS02655	COG2960	long-chain fatty acid transporting porin activity
HKJ33_RS02660	COG0606	chelatase, subunit chli
HKJ33_RS02680	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HKJ33_RS02740	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HKJ33_RS02745	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HKJ33_RS02760	COG1187	pseudouridine synthase activity
HKJ33_RS02765	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HKJ33_RS02785	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HKJ33_RS02790	COG0625	glutathione transferase activity
HKJ33_RS02800	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HKJ33_RS02845	COG0842	Transport permease protein
HKJ33_RS02850	COG1131	(ABC) transporter
HKJ33_RS02870	COG1643	Atp-dependent helicase
HKJ33_RS02885	COG1956	GAF domain-containing protein
HKJ33_RS02895	COG0729	surface antigen
HKJ33_RS02900	COG2911	Protein conserved in bacteria
HKJ33_RS02955	COG3657	addiction module killer protein
HKJ33_RS02960	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HKJ33_RS02990	COG3657	addiction module killer protein
HKJ33_RS02995	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HKJ33_RS03060	COG2369	cell adhesion
HKJ33_RS03105	COG3772	lysozyme
HKJ33_RS03120	COG0305	Participates in initiation and elongation during chromosome replication
HKJ33_RS03135	COG3617	BRO family, N-terminal domain
HKJ33_RS03160	COG4197	protein conserved in bacteria, prophage-related
HKJ33_RS03230	COG5532	Uncharacterized conserved protein (DUF2303)
HKJ33_RS03250	COG0629	single-stranded DNA binding
HKJ33_RS03350	COG0668	transmembrane transport
HKJ33_RS03380	COG5297	Belongs to the glycosyl hydrolase family 6
HKJ33_RS03415	COG2733	membrane
HKJ33_RS03420	COG1253	flavin adenine dinucleotide binding
HKJ33_RS03470	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HKJ33_RS03485	COG0644	oxidoreductase
HKJ33_RS03485	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HKJ33_RS03500	COG3218	ABC-type transport auxiliary lipoprotein component
HKJ33_RS03500	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HKJ33_RS03505	COG1127	ABC transporter
HKJ33_RS03510	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HKJ33_RS03545	COG0629	single-stranded DNA binding
HKJ33_RS03570	COG4969	Belongs to the N-Me-Phe pilin family
HKJ33_RS03685	COG0675	Transposase, IS605 OrfB family
HKJ33_RS03720	COG1077	Cell shape determining protein MreB Mrl
HKJ33_RS03725	COG1792	Involved in formation and maintenance of cell shape
HKJ33_RS03730	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HKJ33_RS03735	COG0768	penicillin binding
HKJ33_RS03740	COG0772	Belongs to the SEDS family
HKJ33_RS03750	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HKJ33_RS03770	COG2894	cell division
HKJ33_RS03790	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HKJ33_RS03805	COG2353	YceI-like domain
HKJ33_RS03850	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HKJ33_RS03855	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HKJ33_RS03860	COG4208	sulfate ABC transporter
HKJ33_RS03885	COG1846	Transcriptional regulator
HKJ33_RS03915	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HKJ33_RS03925	COG0741	lytic transglycosylase activity
HKJ33_RS03955	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HKJ33_RS03990	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HKJ33_RS04000	COG0514	ATP-dependent DNA helicase (RecQ)
HKJ33_RS04005	COG0783	Belongs to the Dps family
HKJ33_RS04010	COG1643	Atp-dependent helicase
HKJ33_RS04020	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HKJ33_RS04025	COG1845	cytochrome c oxidase, subunit III
HKJ33_RS04030	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HKJ33_RS04035	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HKJ33_RS04040	COG0142	geranyltranstransferase activity
HKJ33_RS04045	COG0629	single-stranded DNA binding
HKJ33_RS04085	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HKJ33_RS04120	COG1137	ATPase activity
HKJ33_RS04135	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HKJ33_RS04145	COG0271	Belongs to the BolA IbaG family
HKJ33_RS04180	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HKJ33_RS04190	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HKJ33_RS04205	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HKJ33_RS04225	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HKJ33_RS04255	COG0542	response to heat
HKJ33_RS04275	COG0492	ferredoxin-NADP+ reductase activity
HKJ33_RS04295	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HKJ33_RS04305	COG4191	Histidine kinase
HKJ33_RS04310	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HKJ33_RS04315	COG1028	Short-chain dehydrogenase reductase Sdr
HKJ33_RS04345	COG1609	Transcriptional regulator
HKJ33_RS04350	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HKJ33_RS04355	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HKJ33_RS04360	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HKJ33_RS04365	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HKJ33_RS04370	COG0726	polysaccharide deacetylase
HKJ33_RS04375	COG0297	glycogen (starch) synthase activity
HKJ33_RS04390	COG0719	Fe-S assembly protein
HKJ33_RS04395	COG0396	ATPase activity
HKJ33_RS04400	COG0719	Fe-S assembly protein
HKJ33_RS04405	COG1959	2 iron, 2 sulfur cluster binding
HKJ33_RS04595	COG3772	lysozyme
HKJ33_RS04700	COG3617	BRO family, N-terminal domain
HKJ33_RS04740	COG0308	aminopeptidase N
HKJ33_RS04785	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HKJ33_RS04810	COG1561	YicC-like family, N-terminal region
HKJ33_RS04825	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HKJ33_RS04865	COG5295	Hep Hag repeat protein
HKJ33_RS04870	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HKJ33_RS04875	COG1459	type II secretion system
HKJ33_RS04880	COG2165	general secretion pathway protein
HKJ33_RS04885	COG4970	Tfp pilus assembly protein FimT
HKJ33_RS04890	COG2165	general secretion pathway protein
HKJ33_RS04895	COG4795	General secretion pathway protein
HKJ33_RS04900	COG3156	type II secretion system protein K
HKJ33_RS04905	COG3166	PFAM Fimbrial assembly family protein
HKJ33_RS04920	COG1450	Type ii and iii secretion system protein
HKJ33_RS04935	COG3634	alkyl hydroperoxide reductase activity
HKJ33_RS04940	COG0583	DNA-binding transcription factor activity
HKJ33_RS05005	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HKJ33_RS05025	COG0508	dehydrogenase complex catalyzes the overall conversion of
HKJ33_RS05030	COG0567	Dehydrogenase, E1 component
HKJ33_RS05035	COG2850	peptidyl-arginine hydroxylation
HKJ33_RS05145	COG3772	lysozyme
HKJ33_RS05225	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HKJ33_RS05230	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HKJ33_RS05235	COG2902	Dehydrogenase
HKJ33_RS05275	COG1028	Short-chain dehydrogenase reductase Sdr
HKJ33_RS05305	COG1472	Belongs to the glycosyl hydrolase 3 family
HKJ33_RS05325	COG2925	Exonuclease
HKJ33_RS05335	COG0025	NhaP-type Na H and K H
HKJ33_RS05355	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HKJ33_RS05380	COG0006	proline dipeptidase activity
HKJ33_RS05390	COG0778	Nitroreductase
HKJ33_RS05425	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HKJ33_RS05460	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HKJ33_RS05475	COG0557	exoribonuclease II activity
HKJ33_RS05485	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HKJ33_RS05500	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
HKJ33_RS05505	COG1289	transmembrane transporter activity
HKJ33_RS05530	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HKJ33_RS05540	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HKJ33_RS05555	COG0596	Alpha beta hydrolase
HKJ33_RS05560	COG0727	PFAM Uncharacterised protein family (UPF0153)
HKJ33_RS05565	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HKJ33_RS05565	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HKJ33_RS05605	COG0840	transmembrane signaling receptor activity
HKJ33_RS05610	COG0643	Histidine kinase
HKJ33_RS05610	COG0784	Response regulator, receiver
HKJ33_RS05610	COG2198	Histidine kinase
HKJ33_RS05640	COG0285	dihydrofolate synthase activity
HKJ33_RS05650	COG0339	signal peptide processing
HKJ33_RS05670	COG1301	dicarboxylic acid transport
HKJ33_RS05675	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HKJ33_RS05685	COG2091	lysine biosynthetic process via aminoadipic acid
HKJ33_RS05720	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HKJ33_RS05745	COG0084	hydrolase, TatD family'
HKJ33_RS05760	COG0552	protein localization to endoplasmic reticulum
HKJ33_RS05805	COG0824	Thioesterase
HKJ33_RS05830	COG2885	chlorophyll binding
HKJ33_RS05840	COG0602	queuosine metabolic process
HKJ33_RS05855	COG3104	oligopeptide transport
HKJ33_RS05860	COG0386	Belongs to the glutathione peroxidase family
HKJ33_RS05880	COG0406	alpha-ribazole phosphatase activity
HKJ33_RS06105	COG3852	Histidine kinase
HKJ33_RS06110	COG2204	response regulator
HKJ33_RS06125	COG0004	ammonium transporteR
HKJ33_RS06130	COG0347	Belongs to the P(II) protein family
HKJ33_RS06135	COG0174	glutamine synthetase
HKJ33_RS06140	COG1968	undecaprenyl-diphosphatase activity
HKJ33_RS06145	COG2353	YceI-like domain
HKJ33_RS06250	COG3772	lysozyme
HKJ33_RS06350	COG3617	BRO family, N-terminal domain
HKJ33_RS06380	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HKJ33_RS06430	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HKJ33_RS06435	COG1764	response to oxidative stress
HKJ33_RS06440	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HKJ33_RS06450	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HKJ33_RS06475	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HKJ33_RS06485	COG1399	metal-binding, possibly nucleic acid-binding protein
HKJ33_RS06495	COG0714	Associated with various cellular activities
HKJ33_RS06515	COG0537	adenosine 5'-monophosphoramidase activity
HKJ33_RS06570	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HKJ33_RS06600	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HKJ33_RS06620	COG4969	Belongs to the N-Me-Phe pilin family
HKJ33_RS06635	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HKJ33_RS06640	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HKJ33_RS06650	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HKJ33_RS06660	COG0251	oxidation-reduction process
HKJ33_RS06665	COG0392	lysyltransferase activity
HKJ33_RS06665	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HKJ33_RS06675	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HKJ33_RS06685	COG0463	Glycosyl transferase, family 2
HKJ33_RS06730	COG3275	phosphorelay sensor kinase activity
HKJ33_RS06735	COG0400	carboxylic ester hydrolase activity
HKJ33_RS06755	COG2226	methyltransferase
HKJ33_RS06770	COG2027	D-alanyl-D-alanine carboxypeptidase
HKJ33_RS06785	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HKJ33_RS06825	COG1131	(ABC) transporter
HKJ33_RS06950	COG2369	cell adhesion
HKJ33_RS06955	COG3567	Phage-associated protein, HI1409 family
HKJ33_RS06985	COG3772	lysozyme
HKJ33_RS07050	COG0489	protein tyrosine kinase activity
HKJ33_RS07060	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HKJ33_RS07135	COG0489	protein tyrosine kinase activity
HKJ33_RS07145	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HKJ33_RS07205	COG0488	(ABC) transporter
HKJ33_RS07225	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HKJ33_RS07225	COG4651	solute:proton antiporter activity
HKJ33_RS07285	COG0859	PFAM glycosyl transferase family 9
HKJ33_RS07300	COG0631	protein serine/threonine phosphatase activity
HKJ33_RS07305	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HKJ33_RS07310	COG0328	RNA-DNA hybrid ribonuclease activity
HKJ33_RS07335	COG2183	response to ionizing radiation
HKJ33_RS07350	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HKJ33_RS07355	COG3118	belongs to the thioredoxin family
HKJ33_RS07405	COG2951	lytic endotransglycosylase activity
HKJ33_RS07410	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HKJ33_RS07530	COG0277	FAD linked oxidase domain protein
HKJ33_RS07535	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HKJ33_RS07540	COG0531	amino acid
HKJ33_RS07545	COG0531	amino acid
HKJ33_RS07625	COG0460	homoserine dehydrogenase
HKJ33_RS07625	COG0527	aspartate kinase activity
HKJ33_RS07630	COG0540	Belongs to the ATCase OTCase family
HKJ33_RS07645	COG1686	Belongs to the peptidase S11 family
HKJ33_RS07670	COG4953	penicillin-binding protein 1C
HKJ33_RS07690	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HKJ33_RS07760	COG1506	peptidase
HKJ33_RS07760	COG0823	Involved in the tonB-independent uptake of proteins
HKJ33_RS07765	COG1297	OPT oligopeptide transporter protein
HKJ33_RS07795	COG0676	glucose-6-phosphate 1-epimerase activity
HKJ33_RS07805	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HKJ33_RS07810	COG1335	isochorismatase
HKJ33_RS07815	COG0318	PFAM AMP-dependent synthetase and ligase
HKJ33_RS07825	COG0463	Glycosyl transferase, family 2
HKJ33_RS07840	COG1192	Involved in chromosome partitioning
HKJ33_RS07900	COG3772	lysozyme
HKJ33_RS07955	COG1605	Chorismate mutase
HKJ33_RS07955	COG0077	Prephenate dehydratase
HKJ33_RS07970	COG1668	transmembrane transport
HKJ33_RS07975	COG4555	ABC transporter
HKJ33_RS08000	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HKJ33_RS08015	COG0287	Prephenate dehydrogenase
HKJ33_RS08015	COG1605	Chorismate mutase
HKJ33_RS08040	COG0497	DNA recombination
HKJ33_RS08050	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HKJ33_RS08055	COG2914	Belongs to the UPF0125 (RnfH) family
HKJ33_RS08075	COG1278	Cold shock
HKJ33_RS08095	COG2954	triphosphatase activity
HKJ33_RS08105	COG0745	RESPONSE REGULATOR receiver
HKJ33_RS08110	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HKJ33_RS08115	COG0438	transferase activity, transferring glycosyl groups
HKJ33_RS08125	COG0438	transferase activity, transferring glycosyl groups
HKJ33_RS08185	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HKJ33_RS08190	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HKJ33_RS08205	COG1064	alcohol dehydrogenase
HKJ33_RS08225	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HKJ33_RS08250	COG3609	addiction module antidote protein, CC2985 family
HKJ33_RS08260	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HKJ33_RS08265	COG0675	Transposase, IS605 OrfB family
HKJ33_RS08275	COG0436	Aminotransferase
HKJ33_RS08340	COG0196	riboflavin kinase activity
HKJ33_RS08345	COG0728	peptidoglycan biosynthetic process
HKJ33_RS08350	COG0268	Binds directly to 16S ribosomal RNA
HKJ33_RS08370	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HKJ33_RS08390	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HKJ33_RS08395	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HKJ33_RS08410	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HKJ33_RS08420	COG0776	regulation of translation
HKJ33_RS08465	COG0395	ABC-type sugar transport system, permease component
HKJ33_RS08470	COG1175	transmembrane transport
HKJ33_RS08495	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HKJ33_RS08515	COG0436	Aminotransferase
HKJ33_RS08520	COG4133	protoheme IX ABC transporter activity
HKJ33_RS08540	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
HKJ33_RS08550	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HKJ33_RS08580	COG5434	Belongs to the glycosyl hydrolase 28 family
HKJ33_RS08600	COG0402	S-adenosylhomocysteine deaminase activity
HKJ33_RS08610	COG1509	lysine 2,3-aminomutase activity
HKJ33_RS08645	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HKJ33_RS08650	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HKJ33_RS08665	COG1028	Short-chain dehydrogenase reductase Sdr
HKJ33_RS08710	COG0142	geranyltranstransferase activity
HKJ33_RS08720	COG0037	tRNA processing
HKJ33_RS08735	COG1301	dicarboxylic acid transport
HKJ33_RS08740	COG0791	NLP P60 protein
HKJ33_RS08745	COG0791	NLP P60 protein
HKJ33_RS08755	COG2311	Membrane
HKJ33_RS08770	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HKJ33_RS08895	COG0351	phosphomethylpyrimidine kinase
HKJ33_RS08895	COG0352	thiamine-phosphate diphosphorylase activity
HKJ33_RS08905	COG1324	tolerance protein
HKJ33_RS08940	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HKJ33_RS08945	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HKJ33_RS08950	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HKJ33_RS08965	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HKJ33_RS08985	COG4774	siderophore transport
HKJ33_RS09010	COG1477	protein flavinylation
HKJ33_RS09015	COG1555	photosystem II stabilization
HKJ33_RS09020	COG3178	'Phosphotransferase
HKJ33_RS09025	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HKJ33_RS09035	COG0628	permease
HKJ33_RS09045	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HKJ33_RS09050	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HKJ33_RS09075	COG3590	peptidase
HKJ33_RS09130	COG0519	Catalyzes the synthesis of GMP from XMP
HKJ33_RS09130	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HKJ33_RS09145	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
HKJ33_RS09160	COG3107	peptidoglycan biosynthetic process
HKJ33_RS09180	COG2878	Part of a membrane complex involved in electron transport
HKJ33_RS09230	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HKJ33_RS09285	COG1611	Belongs to the LOG family
HKJ33_RS09290	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HKJ33_RS09295	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HKJ33_RS09305	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HKJ33_RS09335	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HKJ33_RS09350	COG0330	HflC and HflK could
HKJ33_RS09355	COG0330	HflC and HflK could
HKJ33_RS09360	COG0604	alcohol dehydrogenase
HKJ33_RS09390	COG1183	phosphatidylcholine synthase activity
HKJ33_RS09410	COG0668	transmembrane transport
HKJ33_RS09415	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HKJ33_RS09430	COG1610	YqeY-like protein
HKJ33_RS09440	COG0358	DNA primase activity
HKJ33_RS09470	COG1074	ATP-dependent DNA helicase activity
HKJ33_RS09475	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HKJ33_RS09480	COG1127	ABC transporter
HKJ33_RS09485	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HKJ33_RS09505	COG2853	Lipoprotein
HKJ33_RS09510	COG1322	Protein conserved in bacteria
HKJ33_RS09515	COG1116	anion transmembrane transporter activity
HKJ33_RS09525	COG0531	amino acid
HKJ33_RS09530	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HKJ33_RS09535	COG0861	Integral membrane protein TerC family
HKJ33_RS09575	COG2193	ferroxidase activity
HKJ33_RS09605	COG2205	protein histidine kinase activity
HKJ33_RS09610	COG0745	RESPONSE REGULATOR receiver
HKJ33_RS09615	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HKJ33_RS09640	COG0542	response to heat
HKJ33_RS09655	COG2124	cytochrome p450
HKJ33_RS09660	COG2194	sulfuric ester hydrolase activity
HKJ33_RS09700	COG0667	Aldo Keto reductase
HKJ33_RS09705	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HKJ33_RS09715	COG0305	Participates in initiation and elongation during chromosome replication
HKJ33_RS09735	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HKJ33_RS09745	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HKJ33_RS09750	COG0277	FAD linked oxidase domain protein
HKJ33_RS09760	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HKJ33_RS09765	COG4206	TonB-dependent receptor
HKJ33_RS09845	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HKJ33_RS09865	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HKJ33_RS09895	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HKJ33_RS09895	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HKJ33_RS09915	COG0488	(ABC) transporter
HKJ33_RS09925	COG3011	Protein conserved in bacteria
HKJ33_RS09935	COG0564	pseudouridine synthase activity
HKJ33_RS09960	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HKJ33_RS09985	COG0758	DNA mediated transformation
HKJ33_RS10030	COG2969	positive regulation of protein catabolic process
HKJ33_RS10035	COG0625	glutathione transferase activity
HKJ33_RS10040	COG2857	Cytochrome c1
HKJ33_RS10045	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HKJ33_RS10050	COG0723	plastoquinol--plastocyanin reductase activity
HKJ33_RS10055	COG0741	lytic transglycosylase activity
HKJ33_RS10065	COG1702	phosphate starvation-inducible protein PhoH
HKJ33_RS10080	COG4535	Mg2 and Co2 transporter CorC
HKJ33_RS10090	COG0598	Magnesium transport protein CorA
HKJ33_RS10165	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HKJ33_RS10175	COG1199	ATP-dependent helicase activity
HKJ33_RS10190	COG0288	reversible hydration of carbon dioxide
HKJ33_RS10215	COG2011	ABC-type metal ion transport system permease component
HKJ33_RS10220	COG1464	Belongs to the NlpA lipoprotein family
HKJ33_RS10235	COG0508	dehydrogenase complex catalyzes the overall conversion of
HKJ33_RS10240	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HKJ33_RS10255	COG0626	cystathionine gamma-synthase activity
HKJ33_RS10260	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HKJ33_RS10265	COG0739	heme binding
HKJ33_RS10285	COG1238	metal cluster binding
HKJ33_RS10300	COG5002	protein histidine kinase activity
HKJ33_RS10320	COG3858	chitin binding
HKJ33_RS10320	COG1388	LysM domain
HKJ33_RS10325	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HKJ33_RS10335	COG1472	Belongs to the glycosyl hydrolase 3 family
HKJ33_RS10350	COG3537	Alpha-1,2-mannosidase
HKJ33_RS10375	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HKJ33_RS10380	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HKJ33_RS10425	COG0469	pyruvate kinase activity
HKJ33_RS10445	COG0735	belongs to the Fur family
HKJ33_RS10455	COG5297	Belongs to the glycosyl hydrolase family 6
HKJ33_RS10455	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HKJ33_RS10465	COG0612	Peptidase, M16
HKJ33_RS10485	COG4305	rare lipoprotein A
HKJ33_RS10495	COG0739	heme binding
HKJ33_RS10505	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HKJ33_RS10520	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HKJ33_RS10550	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HKJ33_RS10565	COG3116	cell division
HKJ33_RS10580	COG0471	metal ion transport
HKJ33_RS10580	COG3273	potassium ion transport
HKJ33_RS10635	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HKJ33_RS10680	COG0730	response to heat
HKJ33_RS10700	COG0860	N-Acetylmuramoyl-L-alanine amidase
HKJ33_RS10705	COG0802	atpase or kinase
HKJ33_RS10710	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HKJ33_RS10710	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HKJ33_RS10715	COG1570	exodeoxyribonuclease VII activity
HKJ33_RS10780	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HKJ33_RS10845	COG3657	addiction module killer protein
HKJ33_RS10850	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HKJ33_RS10915	COG2369	cell adhesion
HKJ33_RS10920	COG3567	Phage-associated protein, HI1409 family
HKJ33_RS10950	COG3772	lysozyme
HKJ33_RS10980	COG3617	BRO family, N-terminal domain
HKJ33_RS10985	COG3617	BRO family, N-terminal domain
HKJ33_RS11090	COG5532	Uncharacterized conserved protein (DUF2303)
HKJ33_RS11110	COG0629	single-stranded DNA binding
HKJ33_RS11120	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HKJ33_RS11135	COG0745	RESPONSE REGULATOR receiver
HKJ33_RS11140	COG0642	Histidine kinase
HKJ33_RS11150	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HKJ33_RS11195	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HKJ33_RS11205	COG2831	hemolysin activation secretion protein
HKJ33_RS11230	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
HKJ33_RS11270	COG0316	Belongs to the HesB IscA family
HKJ33_RS11305	COG0697	spore germination
HKJ33_RS11310	COG0671	phosphoesterase, PA-phosphatase related
HKJ33_RS11315	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HKJ33_RS11325	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
HKJ33_RS11330	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HKJ33_RS11345	COG1132	(ABC) transporter
HKJ33_RS11350	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HKJ33_RS11355	COG1538	Outer membrane efflux protein
HKJ33_RS11385	COG0745	RESPONSE REGULATOR receiver
HKJ33_RS11390	COG4783	chaperone-mediated protein folding
HKJ33_RS11400	COG0473	3-isopropylmalate dehydrogenase activity
HKJ33_RS11410	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HKJ33_RS11415	COG3083	sulfuric ester hydrolase activity
HKJ33_RS11420	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HKJ33_RS11445	COG0564	pseudouridine synthase activity
HKJ33_RS11450	COG1530	ribonuclease E activity
HKJ33_RS11470	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HKJ33_RS11495	COG1278	Cold shock
HKJ33_RS11500	COG4251	negative regulation of phosphorylation
HKJ33_RS11500	COG5001	Diguanylate cyclase
HKJ33_RS11500	COG3706	GGDEF domain
HKJ33_RS11500	COG2203	Gaf domain
HKJ33_RS11510	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HKJ33_RS11555	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HKJ33_RS11560	COG0250	Participates in transcription elongation, termination and antitermination
HKJ33_RS11565	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HKJ33_RS11575	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HKJ33_RS11595	COG0012	GTP binding
HKJ33_RS11610	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HKJ33_RS11685	COG2095	MarC family integral membrane protein
HKJ33_RS11690	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HKJ33_RS11715	COG2132	Multicopper oxidase
HKJ33_RS11725	COG0210	DNA helicase
HKJ33_RS11735	COG0616	signal peptide processing
HKJ33_RS11755	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HKJ33_RS11770	COG2201	protein-glutamate methylesterase activity
HKJ33_RS11775	COG2177	Part of the ABC transporter FtsEX involved in
HKJ33_RS11780	COG2884	Cell division ATP-binding protein ftsE
HKJ33_RS11785	COG0513	Belongs to the DEAD box helicase family
HKJ33_RS11790	COG3118	belongs to the thioredoxin family
HKJ33_RS11795	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HKJ33_RS11810	COG0793	Belongs to the peptidase S41A family
HKJ33_RS11815	COG4942	peptidase
HKJ33_RS11830	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HKJ33_RS11835	COG0493	'glutamate synthase
HKJ33_RS11840	COG0069	glutamate synthase activity
HKJ33_RS11840	COG0067	glutamate synthase
HKJ33_RS11840	COG0070	glutamate synthase
HKJ33_RS11885	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HKJ33_RS11930	COG1280	lysine exporter protein (LysE YggA)
HKJ33_RS11945	COG4942	peptidase
HKJ33_RS11995	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HKJ33_RS12105	COG1487	ribonuclease activity
HKJ33_RS12110	COG4691	Plasmid stability protein
HKJ33_RS12205	COG0594	ribonuclease P activity