locus-tag	class	description
PLS229_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
PLS229_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
PLS229_RS00020	COG0187	DNA topoisomerase II activity
PLS229_RS00030	COG0501	Belongs to the peptidase M48B family
PLS229_RS00075	COG0408	coproporphyrinogen oxidase activity
PLS229_RS00100	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
PLS229_RS00175	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
PLS229_RS00185	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
PLS229_RS00195	COG0511	ligase activity, forming carbon-carbon bonds
PLS229_RS00200	COG0439	Biotin carboxylase
PLS229_RS00205	COG0210	DNA helicase
PLS229_RS00240	COG1040	competence protein
PLS229_RS00245	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
PLS229_RS00250	COG1752	Esterase of the alpha-beta hydrolase superfamily
PLS229_RS00255	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
PLS229_RS00270	COG2027	D-alanyl-D-alanine carboxypeptidase
PLS229_RS00305	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
PLS229_RS00315	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
PLS229_RS00340	COG3121	Chaperone
PLS229_RS00345	COG3539	Fimbrial protein
PLS229_RS00350	COG1546	Belongs to the CinA family
PLS229_RS00355	COG0477	Major facilitator Superfamily
PLS229_RS00360	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
PLS229_RS00365	COG1923	regulation of RNA biosynthetic process
PLS229_RS00375	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
PLS229_RS00380	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
PLS229_RS00390	COG1534	Rna-binding protein
PLS229_RS00405	COG0129	dihydroxy-acid dehydratase activity
PLS229_RS00435	COG1560	Kdo2-lipid A biosynthetic process
PLS229_RS00440	COG1519	Transferase
PLS229_RS00455	COG0228	four-way junction DNA binding
PLS229_RS00460	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
PLS229_RS00465	COG0336	Belongs to the RNA methyltransferase TrmD family
PLS229_RS00470	COG0335	large ribosomal subunit rRNA binding
PLS229_RS00490	COG1393	Belongs to the ArsC family
PLS229_RS00500	COG0367	asparagine synthase
PLS229_RS00510	COG2070	2-Nitropropane dioxygenase
PLS229_RS00530	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
PLS229_RS00545	COG0339	signal peptide processing
PLS229_RS00570	COG0525	valine-tRNA ligase activity
PLS229_RS00610	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
PLS229_RS00635	COG4221	oxidoreductase activity
PLS229_RS00645	COG0018	arginyl-trna synthetase
PLS229_RS00650	COG2003	Belongs to the UPF0758 family
PLS229_RS00655	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
PLS229_RS00720	COG2223	nitrite transmembrane transporter activity
PLS229_RS00725	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
PLS229_RS00730	COG0739	heme binding
PLS229_RS00735	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
PLS229_RS00765	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
PLS229_RS00790	COG1028	Short-chain dehydrogenase reductase Sdr
PLS229_RS00800	COG1272	protein, Hemolysin III
PLS229_RS00805	COG0463	Glycosyl transferase, family 2
PLS229_RS00810	COG0084	hydrolase, TatD family'
PLS229_RS00825	COG0509	glycine decarboxylation via glycine cleavage system
PLS229_RS00830	COG0404	The glycine cleavage system catalyzes the degradation of glycine
PLS229_RS00840	COG0330	HflC and HflK could
PLS229_RS00845	COG3956	TIGRFAM MazG family protein
PLS229_RS00850	COG1218	3'(2'),5'-bisphosphate nucleotidase
PLS229_RS00855	COG0494	nUDIX hydrolase
PLS229_RS00865	COG1385	rRNA (uridine-N3-)-methyltransferase activity
PLS229_RS00875	COG0513	Belongs to the DEAD box helicase family
PLS229_RS00880	COG0720	synthase
PLS229_RS00915	COG0587	DNA-directed DNA polymerase activity
PLS229_RS00925	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
PLS229_RS00930	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
PLS229_RS00945	COG0512	Glutamine amidotransferase of anthranilate synthase
PLS229_RS00950	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
PLS229_RS00995	COG0006	proline dipeptidase activity
PLS229_RS01020	COG1862	Preprotein translocase
PLS229_RS01025	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
PLS229_RS01030	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
PLS229_RS01040	COG0617	tRNA 3'-terminal CCA addition
PLS229_RS01055	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
PLS229_RS01060	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
PLS229_RS01065	COG0166	Belongs to the GPI family
PLS229_RS01075	COG0779	Required for maturation of 30S ribosomal subunits
PLS229_RS01080	COG0195	Participates in both transcription termination and antitermination
PLS229_RS01085	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
PLS229_RS01090	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
PLS229_RS01095	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
PLS229_RS01105	COG1185	polyribonucleotide nucleotidyltransferase activity
PLS229_RS01110	COG1733	regulation of RNA biosynthetic process
PLS229_RS01115	COG0702	epimerase
PLS229_RS01130	COG0475	glutathione-regulated potassium exporter activity
PLS229_RS01160	COG2086	electron transfer activity
PLS229_RS01190	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
PLS229_RS01250	COG0477	Major facilitator Superfamily
PLS229_RS01275	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
PLS229_RS01280	COG0671	phosphoesterase, PA-phosphatase related
PLS229_RS01310	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
PLS229_RS01320	COG0628	permease
PLS229_RS01340	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PLS229_RS01345	COG1090	epimerase
PLS229_RS01350	COG0318	PFAM AMP-dependent synthetase and ligase
PLS229_RS01370	COG1049	propionate catabolic process, 2-methylcitrate cycle
PLS229_RS01385	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
PLS229_RS01390	COG0732	type I restriction modification DNA specificity domain
PLS229_RS01400	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
PLS229_RS01435	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PLS229_RS01445	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PLS229_RS01455	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
PLS229_RS01460	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
PLS229_RS01465	COG1034	ATP synthesis coupled electron transport
PLS229_RS01500	COG1007	ATP synthesis coupled electron transport
PLS229_RS01505	COG1028	Short-chain dehydrogenase reductase Sdr
PLS229_RS01510	COG2851	Citrate transporter
PLS229_RS01525	COG0642	Histidine kinase
PLS229_RS01540	COG0784	Response regulator, receiver
PLS229_RS01540	COG2205	protein histidine kinase activity
PLS229_RS01540	COG2198	Histidine kinase
PLS229_RS01550	COG1301	dicarboxylic acid transport
PLS229_RS01555	COG0281	malic enzyme
PLS229_RS01555	COG0280	phosphate acetyltransferase
PLS229_RS01565	COG0742	ribosomal rna small subunit methyltransferase
PLS229_RS01580	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
PLS229_RS01590	COG3706	GGDEF domain
PLS229_RS01600	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
PLS229_RS01605	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
PLS229_RS01635	COG2166	iron-sulfur cluster assembly
PLS229_RS01640	COG0215	cysteine-tRNA ligase activity
PLS229_RS01660	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
PLS229_RS01680	COG0165	Argininosuccinate lyase
PLS229_RS01695	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
PLS229_RS01730	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
PLS229_RS01795	COG5314	conjugation
PLS229_RS01835	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
PLS229_RS01850	COG1028	Short-chain dehydrogenase reductase Sdr
PLS229_RS01870	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
PLS229_RS01950	COG1914	H( )-stimulated, divalent metal cation uptake system
PLS229_RS01965	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
PLS229_RS01975	COG1946	Acyl-CoA thioesterase
PLS229_RS02055	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
PLS229_RS02070	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
PLS229_RS02090	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
PLS229_RS02095	COG0575	Belongs to the CDS family
PLS229_RS02135	COG2833	Protein of unknown function (DUF455)
PLS229_RS02140	COG0528	UMP kinase activity
PLS229_RS02215	COG0800	Aldolase
PLS229_RS02225	COG0363	glucosamine-6-phosphate deaminase activity
PLS229_RS02230	COG0837	glucose binding
PLS229_RS02235	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
PLS229_RS02240	COG3842	ATPase activity
PLS229_RS02260	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
PLS229_RS02275	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
PLS229_RS02285	COG4591	ABC-type transport system involved in lipoprotein release permease component
PLS229_RS02290	COG1136	(ABC) transporter
PLS229_RS02295	COG2333	competence protein COMEC
PLS229_RS02295	COG0658	competence protein
PLS229_RS02315	COG1663	tetraacyldisaccharide 4'-kinase activity
PLS229_RS02320	COG0489	protein tyrosine kinase activity
PLS229_RS02325	COG2062	phosphohistidine phosphatase, SixA
PLS229_RS02335	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
PLS229_RS02375	COG0009	L-threonylcarbamoyladenylate synthase
PLS229_RS02380	COG1754	DNA topoisomerase type I activity
PLS229_RS02380	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
PLS229_RS02390	COG2922	Belongs to the Smg family
PLS229_RS02395	COG0758	DNA mediated transformation
PLS229_RS02410	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
PLS229_RS02420	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
PLS229_RS02485	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
PLS229_RS02560	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
PLS229_RS02565	COG0505	Belongs to the CarA family
PLS229_RS02570	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
PLS229_RS02575	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
PLS229_RS02585	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
PLS229_RS02595	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
PLS229_RS02610	COG1024	Enoyl-CoA hydratase
PLS229_RS02615	COG0527	aspartate kinase activity
PLS229_RS02625	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
PLS229_RS02645	COG0494	nUDIX hydrolase
PLS229_RS02655	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
PLS229_RS02670	COG1530	ribonuclease E activity
PLS229_RS02680	COG0312	modulator of DNA gyrase
PLS229_RS02685	COG3028	Belongs to the UPF0307 family
PLS229_RS02690	COG0312	modulator of DNA gyrase
PLS229_RS02715	COG0583	DNA-binding transcription factor activity
PLS229_RS02730	COG1064	alcohol dehydrogenase
PLS229_RS02745	COG0667	Aldo Keto reductase
PLS229_RS02775	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
PLS229_RS02805	COG0356	it plays a direct role in the translocation of protons across the membrane
PLS229_RS02830	COG0089	rRNA binding
PLS229_RS02840	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
PLS229_RS02845	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
PLS229_RS02850	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
PLS229_RS02910	COG1841	ribosomal large subunit assembly
PLS229_RS02915	COG0200	Binds to the 23S rRNA
PLS229_RS02920	COG0201	protein transport
PLS229_RS02925	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
PLS229_RS02930	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
PLS229_RS02950	COG2960	long-chain fatty acid transporting porin activity
PLS229_RS02955	COG0606	chelatase, subunit chli
PLS229_RS02975	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
PLS229_RS02990	COG0544	peptidyl-prolyl cis-trans isomerase activity
PLS229_RS02995	COG0740	serine-type endopeptidase activity
PLS229_RS03000	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
PLS229_RS03035	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
PLS229_RS03040	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
PLS229_RS03065	COG1187	pseudouridine synthase activity
PLS229_RS03070	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
PLS229_RS03090	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
PLS229_RS03145	COG3772	lysozyme
PLS229_RS03185	COG0625	glutathione transferase activity
PLS229_RS03195	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
PLS229_RS03245	COG0842	Transport permease protein
PLS229_RS03250	COG1131	(ABC) transporter
PLS229_RS03270	COG1643	Atp-dependent helicase
PLS229_RS03280	COG1956	GAF domain-containing protein
PLS229_RS03285	COG0729	surface antigen
PLS229_RS03290	COG2911	Protein conserved in bacteria
PLS229_RS03340	COG1937	Protein conserved in bacteria
PLS229_RS03375	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
PLS229_RS03380	COG0668	transmembrane transport
PLS229_RS03410	COG2733	membrane
PLS229_RS03425	COG2921	Belongs to the UPF0250 family
PLS229_RS03430	COG0321	lipoyl(octanoyl) transferase activity
PLS229_RS03435	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
PLS229_RS03460	COG1253	flavin adenine dinucleotide binding
PLS229_RS03485	COG0504	CTP synthase activity
PLS229_RS03490	COG2877	3-deoxy-8-phosphooctulonate synthase activity
PLS229_RS03495	COG0148	phosphopyruvate hydratase activity
PLS229_RS03510	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
PLS229_RS03515	COG2840	Smr protein MutS2
PLS229_RS03525	COG0644	oxidoreductase
PLS229_RS03525	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
PLS229_RS03540	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
PLS229_RS03540	COG3218	ABC-type transport auxiliary lipoprotein component
PLS229_RS03545	COG1127	ABC transporter
PLS229_RS03550	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
PLS229_RS03615	COG1077	Cell shape determining protein MreB Mrl
PLS229_RS03620	COG1792	Involved in formation and maintenance of cell shape
PLS229_RS03625	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
PLS229_RS03630	COG0768	penicillin binding
PLS229_RS03635	COG0772	Belongs to the SEDS family
PLS229_RS03645	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
PLS229_RS03665	COG2894	cell division
PLS229_RS03670	COG0850	regulation of cytokinetic process
PLS229_RS03690	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
PLS229_RS03700	COG3038	cytochrome b561
PLS229_RS03705	COG2353	YceI-like domain
PLS229_RS03710	COG5002	protein histidine kinase activity
PLS229_RS03710	COG0784	Response regulator, receiver
PLS229_RS03720	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
PLS229_RS03745	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PLS229_RS03775	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
PLS229_RS03780	COG4208	sulfate ABC transporter
PLS229_RS03895	COG5532	Uncharacterized conserved protein (DUF2303)
PLS229_RS03920	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
PLS229_RS03940	COG1566	PFAM secretion protein HlyD family protein
PLS229_RS03945	COG2814	Major facilitator Superfamily
PLS229_RS03950	COG2267	carboxylic ester hydrolase activity
PLS229_RS03970	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PLS229_RS03975	COG0617	tRNA 3'-terminal CCA addition
PLS229_RS03980	COG0741	lytic transglycosylase activity
PLS229_RS04060	COG1028	Short-chain dehydrogenase reductase Sdr
PLS229_RS04075	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
PLS229_RS04080	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
PLS229_RS04100	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
PLS229_RS04105	COG0483	inositol monophosphate 1-phosphatase activity
PLS229_RS04115	COG1509	lysine 2,3-aminomutase activity
PLS229_RS04125	COG0402	S-adenosylhomocysteine deaminase activity
PLS229_RS04130	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
PLS229_RS04135	COG0546	phosphoglycolate phosphatase activity
PLS229_RS04145	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
PLS229_RS04185	COG0436	Aminotransferase
PLS229_RS04200	COG1187	pseudouridine synthase activity
PLS229_RS04205	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
PLS229_RS04210	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
PLS229_RS04245	COG0395	ABC-type sugar transport system, permease component
PLS229_RS04260	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
PLS229_RS04265	COG2957	Belongs to the agmatine deiminase family
PLS229_RS04290	COG0776	regulation of translation
PLS229_RS04300	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
PLS229_RS04315	COG1210	Utp--glucose-1-phosphate uridylyltransferase
PLS229_RS04320	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
PLS229_RS04385	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
PLS229_RS04395	COG0211	Belongs to the bacterial ribosomal protein bL27 family
PLS229_RS04400	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
PLS229_RS04405	COG0268	Binds directly to 16S ribosomal RNA
PLS229_RS04410	COG0728	peptidoglycan biosynthetic process
PLS229_RS04415	COG0196	riboflavin kinase activity
PLS229_RS04420	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
PLS229_RS04445	COG1396	sequence-specific DNA binding
PLS229_RS04485	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
PLS229_RS04485	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
PLS229_RS04560	COG0436	Aminotransferase
PLS229_RS04570	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
PLS229_RS04590	COG1902	pentaerythritol trinitrate reductase activity
PLS229_RS04610	COG1064	alcohol dehydrogenase
PLS229_RS04615	COG0604	alcohol dehydrogenase
PLS229_RS04640	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PLS229_RS04645	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PLS229_RS04675	COG0473	3-isopropylmalate dehydrogenase activity
PLS229_RS04705	COG0438	transferase activity, transferring glycosyl groups
PLS229_RS04715	COG2244	polysaccharide biosynthetic process
PLS229_RS04720	COG0438	transferase activity, transferring glycosyl groups
PLS229_RS04735	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
PLS229_RS04740	COG2954	triphosphatase activity
PLS229_RS04745	COG1472	Belongs to the glycosyl hydrolase 3 family
PLS229_RS04760	COG1278	Cold shock
PLS229_RS04785	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
PLS229_RS04795	COG0497	DNA recombination
PLS229_RS04810	COG0443	Heat shock 70 kDa protein
PLS229_RS04815	COG0484	heat shock protein binding
PLS229_RS04830	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
PLS229_RS04840	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
PLS229_RS04855	COG0745	RESPONSE REGULATOR receiver
PLS229_RS04860	COG2205	protein histidine kinase activity
PLS229_RS04870	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
PLS229_RS04875	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
PLS229_RS04895	COG2967	ApaG domain
PLS229_RS04905	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
PLS229_RS04910	COG0704	Plays a role in the regulation of phosphate uptake
PLS229_RS04920	COG0581	inorganic phosphate transmembrane transporter activity
PLS229_RS04925	COG0573	inorganic phosphate transmembrane transporter activity
PLS229_RS04930	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
PLS229_RS04935	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
PLS229_RS04935	COG4651	solute:proton antiporter activity
PLS229_RS04945	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
PLS229_RS04955	COG0488	(ABC) transporter
PLS229_RS04980	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
PLS229_RS04990	COG0489	protein tyrosine kinase activity
PLS229_RS05015	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
PLS229_RS05020	COG1414	Transcriptional regulator
PLS229_RS05070	COG1469	GTP cyclohydrolase I activity
PLS229_RS05080	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PLS229_RS05085	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PLS229_RS05090	COG2902	Dehydrogenase
PLS229_RS05095	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
PLS229_RS05125	COG2925	Exonuclease
PLS229_RS05140	COG0025	NhaP-type Na H and K H
PLS229_RS05160	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
PLS229_RS05180	COG3079	Belongs to the UPF0149 family
PLS229_RS05185	COG0006	proline dipeptidase activity
PLS229_RS05225	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
PLS229_RS05285	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
PLS229_RS05310	COG3772	lysozyme
PLS229_RS05370	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PLS229_RS05380	COG0328	RNA-DNA hybrid ribonuclease activity
PLS229_RS05385	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
PLS229_RS05405	COG0859	PFAM glycosyl transferase family 9
PLS229_RS05415	COG2943	transferase activity, transferring hexosyl groups
PLS229_RS05420	COG0400	carboxylic ester hydrolase activity
PLS229_RS05425	COG3275	phosphorelay sensor kinase activity
PLS229_RS05470	COG0463	Glycosyl transferase, family 2
PLS229_RS05480	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
PLS229_RS05495	COG0392	lysyltransferase activity
PLS229_RS05495	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
PLS229_RS05500	COG0251	oxidation-reduction process
PLS229_RS05515	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
PLS229_RS05520	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
PLS229_RS05525	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
PLS229_RS05530	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
PLS229_RS05550	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
PLS229_RS05600	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
PLS229_RS05710	COG0582	viral genome integration into host DNA
PLS229_RS05725	COG3772	lysozyme
PLS229_RS05780	COG0640	Transcriptional regulator
PLS229_RS05795	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PLS229_RS05820	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
PLS229_RS05855	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
PLS229_RS05860	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
PLS229_RS05870	COG0537	adenosine 5'-monophosphoramidase activity
PLS229_RS05890	COG0714	Associated with various cellular activities
PLS229_RS05900	COG1399	metal-binding, possibly nucleic acid-binding protein
PLS229_RS05905	COG0333	Belongs to the bacterial ribosomal protein bL32 family
PLS229_RS05910	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
PLS229_RS05925	COG5297	Belongs to the glycosyl hydrolase family 6
PLS229_RS05930	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
PLS229_RS05950	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
PLS229_RS05960	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PLS229_RS05965	COG1764	response to oxidative stress
PLS229_RS05970	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
PLS229_RS05975	COG2945	thiolester hydrolase activity
PLS229_RS06035	COG2353	YceI-like domain
PLS229_RS06040	COG1968	undecaprenyl-diphosphatase activity
PLS229_RS06045	COG0174	glutamine synthetase
PLS229_RS06050	COG0347	Belongs to the P(II) protein family
PLS229_RS06055	COG0004	ammonium transporteR
PLS229_RS06080	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
PLS229_RS06085	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
PLS229_RS06090	COG0084	hydrolase, TatD family'
PLS229_RS06125	COG0552	protein localization to endoplasmic reticulum
PLS229_RS06145	COG0217	transcriptional regulatory protein
PLS229_RS06160	COG3158	transport of potassium into the cell
PLS229_RS06170	COG0824	Thioesterase
PLS229_RS06175	COG0811	peptide transport
PLS229_RS06180	COG0848	biopolymer transport protein
PLS229_RS06195	COG2885	chlorophyll binding
PLS229_RS06205	COG0602	queuosine metabolic process
PLS229_RS06215	COG1515	deoxyribonuclease V activity
PLS229_RS06220	COG3104	oligopeptide transport
PLS229_RS06225	COG0386	Belongs to the glutathione peroxidase family
PLS229_RS06235	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
PLS229_RS06245	COG0406	alpha-ribazole phosphatase activity
PLS229_RS06255	COG1487	ribonuclease activity
PLS229_RS06330	COG3041	Addiction module toxin RelE StbE family
PLS229_RS06335	COG3077	Addiction module antitoxin, RelB DinJ family
PLS229_RS06410	COG2337	Toxic component of a toxin-antitoxin (TA) module
PLS229_RS06475	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
PLS229_RS06515	COG2091	lysine biosynthetic process via aminoadipic acid
PLS229_RS06525	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
PLS229_RS06530	COG1301	dicarboxylic acid transport
PLS229_RS06550	COG0339	signal peptide processing
PLS229_RS06560	COG0285	dihydrofolate synthase activity
PLS229_RS06585	COG2201	protein-glutamate methylesterase activity
PLS229_RS06590	COG2198	Histidine kinase
PLS229_RS06590	COG0643	Histidine kinase
PLS229_RS06590	COG0784	Response regulator, receiver
PLS229_RS06595	COG0840	transmembrane signaling receptor activity
PLS229_RS06625	COG0751	glycine-tRNA ligase activity
PLS229_RS06635	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
PLS229_RS06635	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
PLS229_RS06655	COG0727	PFAM Uncharacterised protein family (UPF0153)
PLS229_RS06665	COG0596	Alpha beta hydrolase
PLS229_RS06675	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
PLS229_RS06685	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
PLS229_RS06695	COG0138	bifunctional purine biosynthesis protein purh
PLS229_RS06700	COG0151	Belongs to the GarS family
PLS229_RS06720	COG1289	transmembrane transporter activity
PLS229_RS06730	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
PLS229_RS06740	COG0302	gtp cyclohydrolase
PLS229_RS06750	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
PLS229_RS06760	COG0557	exoribonuclease II activity
PLS229_RS06765	COG3617	BRO family, N-terminal domain
PLS229_RS06770	COG3772	lysozyme
PLS229_RS06860	COG1881	PFAM PEBP family protein
PLS229_RS06865	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
PLS229_RS06870	COG3118	belongs to the thioredoxin family
PLS229_RS06880	COG0495	leucyl-tRNA aminoacylation
PLS229_RS06910	COG2951	lytic endotransglycosylase activity
PLS229_RS07055	COG3210	domain, Protein
PLS229_RS07160	COG3210	domain, Protein
PLS229_RS07185	COG1280	lysine exporter protein (LysE YggA)
PLS229_RS07205	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
PLS229_RS07210	COG0277	FAD linked oxidase domain protein
PLS229_RS07215	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
PLS229_RS07220	COG0531	amino acid
PLS229_RS07225	COG0531	amino acid
PLS229_RS07230	COG0235	Class ii aldolase
PLS229_RS07235	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
PLS229_RS07240	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
PLS229_RS07285	COG0131	Imidazoleglycerol-phosphate dehydratase
PLS229_RS07285	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
PLS229_RS07295	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
PLS229_RS07300	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
PLS229_RS07320	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
PLS229_RS07325	COG0083	homoserine kinase activity
PLS229_RS07330	COG0460	homoserine dehydrogenase
PLS229_RS07330	COG0527	aspartate kinase activity
PLS229_RS07340	COG0540	Belongs to the ATCase OTCase family
PLS229_RS07355	COG1686	Belongs to the peptidase S11 family
PLS229_RS07360	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
PLS229_RS07375	COG4953	penicillin-binding protein 1C
PLS229_RS07415	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PLS229_RS07440	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
PLS229_RS07445	COG1381	Involved in DNA repair and RecF pathway recombination
PLS229_RS07460	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
PLS229_RS07470	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
PLS229_RS07480	COG1028	Short-chain dehydrogenase reductase Sdr
PLS229_RS07495	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
PLS229_RS07500	COG1506	peptidase
PLS229_RS07500	COG0823	Involved in the tonB-independent uptake of proteins
PLS229_RS07505	COG1297	OPT oligopeptide transporter protein
PLS229_RS07530	COG0676	glucose-6-phosphate 1-epimerase activity
PLS229_RS07540	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
PLS229_RS07545	COG0318	PFAM AMP-dependent synthetase and ligase
PLS229_RS07555	COG0463	Glycosyl transferase, family 2
PLS229_RS07565	COG1475	DNA binding
PLS229_RS07570	COG1192	Involved in chromosome partitioning
PLS229_RS07585	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
PLS229_RS07600	COG0077	Prephenate dehydratase
PLS229_RS07600	COG1605	Chorismate mutase
PLS229_RS07615	COG1668	transmembrane transport
PLS229_RS07620	COG4555	ABC transporter
PLS229_RS07650	COG1309	transcriptional regulator
PLS229_RS07655	COG2226	methyltransferase
PLS229_RS07665	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
PLS229_RS07680	COG2900	Belongs to the SlyX family
PLS229_RS07695	COG0386	Belongs to the glutathione peroxidase family
PLS229_RS07705	COG1131	(ABC) transporter
PLS229_RS07730	COG2850	peptidyl-arginine hydroxylation
PLS229_RS07735	COG0567	Dehydrogenase, E1 component
PLS229_RS07755	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
PLS229_RS07780	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
PLS229_RS07810	COG0583	DNA-binding transcription factor activity
PLS229_RS07815	COG3634	alkyl hydroperoxide reductase activity
PLS229_RS07825	COG5295	Hep Hag repeat protein
PLS229_RS07830	COG1450	Type ii and iii secretion system protein
PLS229_RS07845	COG3166	PFAM Fimbrial assembly family protein
PLS229_RS07850	COG3156	type II secretion system protein K
PLS229_RS07860	COG3156	type II secretion system protein K
PLS229_RS07865	COG4795	General secretion pathway protein
PLS229_RS07870	COG2165	general secretion pathway protein
PLS229_RS07875	COG4970	Tfp pilus assembly protein FimT
PLS229_RS07880	COG2165	general secretion pathway protein
PLS229_RS07885	COG1459	type II secretion system
PLS229_RS07890	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
PLS229_RS07935	COG0635	Involved in the biosynthesis of porphyrin-containing compound
PLS229_RS07950	COG1561	YicC-like family, N-terminal region
PLS229_RS07955	COG0194	GDP metabolic process
PLS229_RS07960	COG1758	RNA polymerase activity
PLS229_RS07965	COG2895	sulfate adenylyltransferase (ATP) activity
PLS229_RS07965	COG0529	Catalyzes the synthesis of activated sulfate
PLS229_RS07970	COG0175	sulfate reduction
PLS229_RS07985	COG0175	sulfate reduction
PLS229_RS08035	COG0308	aminopeptidase N
PLS229_RS08040	COG2226	methyltransferase
PLS229_RS08095	COG1959	2 iron, 2 sulfur cluster binding
PLS229_RS08100	COG0719	Fe-S assembly protein
PLS229_RS08105	COG0396	ATPase activity
PLS229_RS08110	COG0719	Fe-S assembly protein
PLS229_RS08115	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
PLS229_RS08120	COG2146	nitrite reductase [NAD(P)H] activity
PLS229_RS08125	COG0297	glycogen (starch) synthase activity
PLS229_RS08130	COG0726	polysaccharide deacetylase
PLS229_RS08135	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
PLS229_RS08140	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
PLS229_RS08160	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
PLS229_RS08165	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
PLS229_RS08185	COG0837	glucose binding
PLS229_RS08210	COG4191	Histidine kinase
PLS229_RS08230	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
PLS229_RS08235	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
PLS229_RS08250	COG1674	ftsk spoiiie
PLS229_RS08255	COG0492	ferredoxin-NADP+ reductase activity
PLS229_RS08265	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
PLS229_RS08270	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
PLS229_RS08275	COG0542	response to heat
PLS229_RS08295	COG2915	High frequency lysogenization protein hflD homolog
PLS229_RS08340	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
PLS229_RS08350	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
PLS229_RS08355	COG0047	phosphoribosylformylglycinamidine synthase activity
PLS229_RS08355	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
PLS229_RS08365	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
PLS229_RS08370	COG0271	Belongs to the BolA IbaG family
PLS229_RS08380	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
PLS229_RS08395	COG1137	ATPase activity
PLS229_RS08415	COG1660	Displays ATPase and GTPase activities
PLS229_RS08425	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
PLS229_RS08430	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
PLS229_RS08435	COG2239	Acts as a magnesium transporter
PLS229_RS08450	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
PLS229_RS08475	COG1595	DNA-templated transcription, initiation
PLS229_RS08500	COG0142	geranyltranstransferase activity
PLS229_RS08510	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
PLS229_RS08515	COG1845	cytochrome c oxidase, subunit III
PLS229_RS08520	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
PLS229_RS08525	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
PLS229_RS08525	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
PLS229_RS08535	COG1643	Atp-dependent helicase
PLS229_RS08540	COG0783	Belongs to the Dps family
PLS229_RS08545	COG0514	ATP-dependent DNA helicase (RecQ)
PLS229_RS08565	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PLS229_RS08610	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
PLS229_RS08690	COG0142	geranyltranstransferase activity
PLS229_RS08695	COG1722	exodeoxyribonuclease VII activity
PLS229_RS08700	COG0037	tRNA processing
PLS229_RS08710	COG1301	dicarboxylic acid transport
PLS229_RS08715	COG0791	NLP P60 protein
PLS229_RS08720	COG0791	NLP P60 protein
PLS229_RS08730	COG2311	Membrane
PLS229_RS08755	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
PLS229_RS08770	COG0545	Peptidyl-prolyl cis-trans isomerase
PLS229_RS08775	COG0494	nUDIX hydrolase
PLS229_RS08785	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
PLS229_RS08800	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
PLS229_RS08805	COG0352	thiamine-phosphate diphosphorylase activity
PLS229_RS08805	COG0351	phosphomethylpyrimidine kinase
PLS229_RS08830	COG1324	tolerance protein
PLS229_RS08865	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PLS229_RS08870	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PLS229_RS08875	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
PLS229_RS08890	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
PLS229_RS08910	COG4774	siderophore transport
PLS229_RS08935	COG1477	protein flavinylation
PLS229_RS08940	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
PLS229_RS08945	COG1555	photosystem II stabilization
PLS229_RS08955	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
PLS229_RS08965	COG0628	permease
PLS229_RS08975	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
PLS229_RS08980	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
PLS229_RS09000	COG3590	peptidase
PLS229_RS09005	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
PLS229_RS09035	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
PLS229_RS09055	COG0519	Catalyzes the synthesis of GMP from XMP
PLS229_RS09055	COG0518	GMP synthase (glutamine-hydrolyzing) activity
PLS229_RS09060	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
PLS229_RS09065	COG1162	GTPase activity
PLS229_RS09075	COG3107	peptidoglycan biosynthetic process
PLS229_RS09100	COG2878	Part of a membrane complex involved in electron transport
PLS229_RS09195	COG1611	Belongs to the LOG family
PLS229_RS09200	COG4943	cyclic-guanylate-specific phosphodiesterase activity
PLS229_RS09210	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
PLS229_RS09215	COG1160	GTP binding
PLS229_RS09220	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
PLS229_RS09250	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
PLS229_RS09265	COG0330	HflC and HflK could
PLS229_RS09270	COG0330	HflC and HflK could
PLS229_RS09275	COG0604	alcohol dehydrogenase
PLS229_RS09305	COG1183	phosphatidylcholine synthase activity
PLS229_RS09315	COG0456	acetyltransferase
PLS229_RS09335	COG0668	transmembrane transport
PLS229_RS09340	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
PLS229_RS09355	COG1610	YqeY-like protein
PLS229_RS09360	COG1295	ribonuclease BN
PLS229_RS09365	COG0358	DNA primase activity
PLS229_RS09375	COG0180	Tryptophanyl-tRNA synthetase
PLS229_RS09385	COG1074	ATP-dependent DNA helicase activity
PLS229_RS09390	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
PLS229_RS09395	COG1127	ABC transporter
PLS229_RS09400	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
PLS229_RS09405	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
PLS229_RS09420	COG2853	Lipoprotein
PLS229_RS09430	COG1116	anion transmembrane transporter activity
PLS229_RS09445	COG0531	amino acid
PLS229_RS09455	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
PLS229_RS09460	COG0861	Integral membrane protein TerC family
PLS229_RS09535	COG2205	protein histidine kinase activity
PLS229_RS09540	COG0745	RESPONSE REGULATOR receiver
PLS229_RS09550	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
PLS229_RS09600	COG2124	cytochrome p450
PLS229_RS09630	COG0305	Participates in initiation and elongation during chromosome replication
PLS229_RS09645	COG0667	Aldo Keto reductase
PLS229_RS09650	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
PLS229_RS09685	COG2194	sulfuric ester hydrolase activity
PLS229_RS09690	COG2124	cytochrome p450
PLS229_RS09695	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
PLS229_RS09705	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
PLS229_RS09715	COG0277	FAD linked oxidase domain protein
PLS229_RS09730	COG4206	TonB-dependent receptor
PLS229_RS09775	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
PLS229_RS09780	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
PLS229_RS09810	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
PLS229_RS09830	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
PLS229_RS09830	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
PLS229_RS09850	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
PLS229_RS09855	COG0488	(ABC) transporter
PLS229_RS09865	COG3011	Protein conserved in bacteria
PLS229_RS09875	COG0564	pseudouridine synthase activity
PLS229_RS09880	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
PLS229_RS09900	COG1028	Short-chain dehydrogenase reductase Sdr
PLS229_RS09905	COG2969	positive regulation of protein catabolic process
PLS229_RS09910	COG0625	glutathione transferase activity
PLS229_RS09930	COG0741	lytic transglycosylase activity
PLS229_RS09940	COG1702	phosphate starvation-inducible protein PhoH
PLS229_RS09955	COG4535	Mg2 and Co2 transporter CorC
PLS229_RS09990	COG3210	domain, Protein
PLS229_RS09995	COG2831	hemolysin activation secretion protein
PLS229_RS10020	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
PLS229_RS10040	COG3115	cell septum assembly
PLS229_RS10055	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
PLS229_RS10065	COG0316	Belongs to the HesB IscA family
PLS229_RS10090	COG0167	dihydroorotate dehydrogenase activity
PLS229_RS10095	COG0812	UDP-N-acetylmuramate dehydrogenase activity
PLS229_RS10100	COG0697	spore germination
PLS229_RS10105	COG0671	phosphoesterase, PA-phosphatase related
PLS229_RS10110	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
PLS229_RS10120	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
PLS229_RS10125	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
PLS229_RS10145	COG1132	(ABC) transporter
PLS229_RS10160	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
PLS229_RS10165	COG1538	Outer membrane efflux protein
PLS229_RS10170	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PLS229_RS10180	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
PLS229_RS10195	COG4783	chaperone-mediated protein folding
PLS229_RS10205	COG0473	3-isopropylmalate dehydrogenase activity
PLS229_RS10215	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
PLS229_RS10225	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
PLS229_RS10235	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
PLS229_RS10235	COG0316	Belongs to the HesB IscA family
PLS229_RS10240	COG2154	pterin-4-alpha-carbinolamine dehydratase
PLS229_RS10255	COG0564	pseudouridine synthase activity
PLS229_RS10260	COG1530	ribonuclease E activity
PLS229_RS10280	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
PLS229_RS10305	COG1278	Cold shock
PLS229_RS10320	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
PLS229_RS10330	COG0049	tRNA binding
PLS229_RS10345	COG0085	RNA polymerase activity
PLS229_RS10350	COG0222	ribosome binding
PLS229_RS10365	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
PLS229_RS10370	COG0250	Participates in transcription elongation, termination and antitermination
PLS229_RS10375	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
PLS229_RS10385	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
PLS229_RS10405	COG0012	GTP binding
PLS229_RS10410	COG0193	aminoacyl-tRNA hydrolase activity
PLS229_RS10415	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
PLS229_RS10420	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
PLS229_RS10430	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
PLS229_RS10435	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
PLS229_RS10445	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
PLS229_RS10525	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PLS229_RS10530	COG0765	amino acid transport
PLS229_RS10535	COG1126	abc transporter atp-binding protein
PLS229_RS10540	COG0765	amino acid transport
PLS229_RS10550	COG2095	MarC family integral membrane protein
PLS229_RS10555	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
PLS229_RS10585	COG2132	Multicopper oxidase
PLS229_RS10595	COG0210	DNA helicase
PLS229_RS10605	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
PLS229_RS10610	COG0616	signal peptide processing
PLS229_RS10630	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
PLS229_RS10635	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
PLS229_RS10640	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
PLS229_RS10650	COG2177	Part of the ABC transporter FtsEX involved in
PLS229_RS10655	COG2884	Cell division ATP-binding protein ftsE
PLS229_RS10660	COG0513	Belongs to the DEAD box helicase family
PLS229_RS10665	COG3118	belongs to the thioredoxin family
PLS229_RS10670	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
PLS229_RS10705	COG0793	Belongs to the peptidase S41A family
PLS229_RS10710	COG4942	peptidase
PLS229_RS10720	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
PLS229_RS10735	COG0493	'glutamate synthase
PLS229_RS10740	COG0069	glutamate synthase activity
PLS229_RS10740	COG0067	glutamate synthase
PLS229_RS10740	COG0070	glutamate synthase
PLS229_RS10840	COG3210	domain, Protein
PLS229_RS10975	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
PLS229_RS10985	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
PLS229_RS10990	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
PLS229_RS11095	COG1028	Short-chain dehydrogenase reductase Sdr
PLS229_RS11115	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
PLS229_RS11125	COG1199	ATP-dependent helicase activity
PLS229_RS11135	COG0288	reversible hydration of carbon dioxide
PLS229_RS11140	COG0438	transferase activity, transferring glycosyl groups
PLS229_RS11155	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
PLS229_RS11160	COG2011	ABC-type metal ion transport system permease component
PLS229_RS11165	COG1464	Belongs to the NlpA lipoprotein family
PLS229_RS11180	COG0508	dehydrogenase complex catalyzes the overall conversion of
PLS229_RS11185	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PLS229_RS11200	COG0626	cystathionine gamma-synthase activity
PLS229_RS11205	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
PLS229_RS11210	COG0739	heme binding
PLS229_RS11215	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
PLS229_RS11220	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
PLS229_RS11240	COG5002	protein histidine kinase activity
PLS229_RS11245	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
PLS229_RS11270	COG3525	Glycosyl hydrolase, family 20, catalytic domain
PLS229_RS11280	COG1472	Belongs to the glycosyl hydrolase 3 family
PLS229_RS11295	COG3537	Alpha-1,2-mannosidase
PLS229_RS11315	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
PLS229_RS11330	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
PLS229_RS11335	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
PLS229_RS11340	COG2207	Transcriptional regulator
PLS229_RS11345	COG2249	NAD(P)H dehydrogenase (quinone) activity
PLS229_RS11375	COG3588	fructose-bisphosphate aldolase
PLS229_RS11385	COG0469	pyruvate kinase activity
PLS229_RS11405	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PLS229_RS11410	COG0735	belongs to the Fur family
PLS229_RS11425	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
PLS229_RS11425	COG5297	Belongs to the glycosyl hydrolase family 6
PLS229_RS11435	COG0612	Peptidase, M16
PLS229_RS11450	COG4305	rare lipoprotein A
PLS229_RS11455	COG0653	protein targeting
PLS229_RS11460	COG0739	heme binding
PLS229_RS11470	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
PLS229_RS11485	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
PLS229_RS11490	COG1181	Belongs to the D-alanine--D-alanine ligase family
PLS229_RS11495	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
PLS229_RS11510	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
PLS229_RS11515	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
PLS229_RS11530	COG3116	cell division
PLS229_RS11535	COG0275	rRNA processing
PLS229_RS11545	COG0471	metal ion transport
PLS229_RS11545	COG3273	potassium ion transport
PLS229_RS11550	COG0220	tRNA (guanine-N7-)-methyltransferase activity
PLS229_RS11595	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
PLS229_RS11620	COG0717	Belongs to the dCTP deaminase family
PLS229_RS11635	COG0860	N-Acetylmuramoyl-L-alanine amidase
PLS229_RS11640	COG0802	atpase or kinase
PLS229_RS11645	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
PLS229_RS11645	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
PLS229_RS11650	COG1570	exodeoxyribonuclease VII activity
PLS229_RS11695	COG0776	regulation of translation
PLS229_RS11700	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PLS229_RS11700	COG0072	phenylalanine-tRNA ligase activity
PLS229_RS11705	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
PLS229_RS11710	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
PLS229_RS11720	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
PLS229_RS11740	COG0745	RESPONSE REGULATOR receiver
PLS229_RS11755	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
PLS229_RS11805	COG0045	succinate-CoA ligase (ADP-forming) activity
PLS229_RS11810	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
PLS229_RS11815	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
PLS229_RS11830	COG0594	ribonuclease P activity