locus-tag	class	description
LPH64_RS00015	COG0552	protein localization to endoplasmic reticulum
LPH64_RS00035	COG0217	transcriptional regulatory protein
LPH64_RS00050	COG3158	transport of potassium into the cell
LPH64_RS00060	COG0824	Thioesterase
LPH64_RS00065	COG0811	peptide transport
LPH64_RS00070	COG0848	biopolymer transport protein
LPH64_RS00085	COG2885	chlorophyll binding
LPH64_RS00095	COG0602	queuosine metabolic process
LPH64_RS00105	COG1515	deoxyribonuclease V activity
LPH64_RS00115	COG0386	Belongs to the glutathione peroxidase family
LPH64_RS00125	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
LPH64_RS00135	COG0406	alpha-ribazole phosphatase activity
LPH64_RS00145	COG3041	Addiction module toxin RelE StbE family
LPH64_RS00150	COG3077	Addiction module antitoxin, RelB DinJ family
LPH64_RS00225	COG2337	Toxic component of a toxin-antitoxin (TA) module
LPH64_RS00285	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
LPH64_RS00330	COG2091	lysine biosynthetic process via aminoadipic acid
LPH64_RS00340	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
LPH64_RS00345	COG1301	dicarboxylic acid transport
LPH64_RS00370	COG0339	signal peptide processing
LPH64_RS00380	COG0285	dihydrofolate synthase activity
LPH64_RS00405	COG2201	protein-glutamate methylesterase activity
LPH64_RS00410	COG0643	Histidine kinase
LPH64_RS00410	COG0784	Response regulator, receiver
LPH64_RS00410	COG2198	Histidine kinase
LPH64_RS00415	COG0840	transmembrane signaling receptor activity
LPH64_RS00445	COG0751	glycine-tRNA ligase activity
LPH64_RS00455	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LPH64_RS00455	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
LPH64_RS00480	COG0727	PFAM Uncharacterised protein family (UPF0153)
LPH64_RS00495	COG0596	Alpha beta hydrolase
LPH64_RS00505	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LPH64_RS00515	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
LPH64_RS00525	COG0138	bifunctional purine biosynthesis protein purh
LPH64_RS00530	COG0151	Belongs to the GarS family
LPH64_RS00550	COG1289	transmembrane transporter activity
LPH64_RS00560	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
LPH64_RS00570	COG0302	gtp cyclohydrolase
LPH64_RS00580	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
LPH64_RS00590	COG0557	exoribonuclease II activity
LPH64_RS00600	COG3772	lysozyme
LPH64_RS00695	COG1881	PFAM PEBP family protein
LPH64_RS00700	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
LPH64_RS00705	COG3118	belongs to the thioredoxin family
LPH64_RS00715	COG0495	leucyl-tRNA aminoacylation
LPH64_RS00745	COG2951	lytic endotransglycosylase activity
LPH64_RS00890	COG3210	domain, Protein
LPH64_RS00990	COG3210	domain, Protein
LPH64_RS01005	COG1280	lysine exporter protein (LysE YggA)
LPH64_RS01025	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LPH64_RS01030	COG0277	FAD linked oxidase domain protein
LPH64_RS01035	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LPH64_RS01040	COG0531	amino acid
LPH64_RS01045	COG0531	amino acid
LPH64_RS01050	COG0235	Class ii aldolase
LPH64_RS01055	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
LPH64_RS01060	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
LPH64_RS01105	COG0131	Imidazoleglycerol-phosphate dehydratase
LPH64_RS01105	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
LPH64_RS01115	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
LPH64_RS01120	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
LPH64_RS01140	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
LPH64_RS01145	COG0083	homoserine kinase activity
LPH64_RS01150	COG0527	aspartate kinase activity
LPH64_RS01150	COG0460	homoserine dehydrogenase
LPH64_RS01160	COG0540	Belongs to the ATCase OTCase family
LPH64_RS01175	COG1686	Belongs to the peptidase S11 family
LPH64_RS01180	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
LPH64_RS01195	COG4953	penicillin-binding protein 1C
LPH64_RS01230	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LPH64_RS01255	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
LPH64_RS01260	COG1381	Involved in DNA repair and RecF pathway recombination
LPH64_RS01275	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LPH64_RS01285	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LPH64_RS01295	COG1028	Short-chain dehydrogenase reductase Sdr
LPH64_RS01310	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LPH64_RS01315	COG0823	Involved in the tonB-independent uptake of proteins
LPH64_RS01315	COG1506	peptidase
LPH64_RS01320	COG1297	OPT oligopeptide transporter protein
LPH64_RS01355	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
LPH64_RS01365	COG0318	PFAM AMP-dependent synthetase and ligase
LPH64_RS01375	COG0463	Glycosyl transferase, family 2
LPH64_RS01385	COG1475	DNA binding
LPH64_RS01390	COG1192	Involved in chromosome partitioning
LPH64_RS01405	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
LPH64_RS01420	COG1605	Chorismate mutase
LPH64_RS01420	COG0077	Prephenate dehydratase
LPH64_RS01435	COG1668	transmembrane transport
LPH64_RS01440	COG4555	ABC transporter
LPH64_RS01470	COG1309	transcriptional regulator
LPH64_RS01475	COG2226	methyltransferase
LPH64_RS01485	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LPH64_RS01500	COG2900	Belongs to the SlyX family
LPH64_RS01515	COG0386	Belongs to the glutathione peroxidase family
LPH64_RS01525	COG1131	(ABC) transporter
LPH64_RS01550	COG2850	peptidyl-arginine hydroxylation
LPH64_RS01555	COG0567	Dehydrogenase, E1 component
LPH64_RS01580	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
LPH64_RS01605	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
LPH64_RS01635	COG0583	DNA-binding transcription factor activity
LPH64_RS01640	COG3634	alkyl hydroperoxide reductase activity
LPH64_RS01650	COG5295	Hep Hag repeat protein
LPH64_RS01655	COG1450	Type ii and iii secretion system protein
LPH64_RS01670	COG3166	PFAM Fimbrial assembly family protein
LPH64_RS01675	COG3156	type II secretion system protein K
LPH64_RS01685	COG3156	type II secretion system protein K
LPH64_RS01690	COG4795	General secretion pathway protein
LPH64_RS01695	COG2165	general secretion pathway protein
LPH64_RS01700	COG4970	Tfp pilus assembly protein FimT
LPH64_RS01705	COG2165	general secretion pathway protein
LPH64_RS01710	COG1459	type II secretion system
LPH64_RS01715	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LPH64_RS01760	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LPH64_RS01775	COG1561	YicC-like family, N-terminal region
LPH64_RS01780	COG0194	GDP metabolic process
LPH64_RS01785	COG1758	RNA polymerase activity
LPH64_RS01790	COG2895	sulfate adenylyltransferase (ATP) activity
LPH64_RS01790	COG0529	Catalyzes the synthesis of activated sulfate
LPH64_RS01795	COG0175	sulfate reduction
LPH64_RS01810	COG0175	sulfate reduction
LPH64_RS01870	COG0308	aminopeptidase N
LPH64_RS01875	COG2226	methyltransferase
LPH64_RS01930	COG1959	2 iron, 2 sulfur cluster binding
LPH64_RS01935	COG0719	Fe-S assembly protein
LPH64_RS01940	COG0396	ATPase activity
LPH64_RS01945	COG0719	Fe-S assembly protein
LPH64_RS01950	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LPH64_RS01955	COG2146	nitrite reductase [NAD(P)H] activity
LPH64_RS01960	COG0297	glycogen (starch) synthase activity
LPH64_RS01965	COG0726	polysaccharide deacetylase
LPH64_RS01970	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LPH64_RS01975	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
LPH64_RS01995	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
LPH64_RS02000	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LPH64_RS02020	COG0837	glucose binding
LPH64_RS02045	COG4191	Histidine kinase
LPH64_RS02065	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LPH64_RS02070	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
LPH64_RS02085	COG1674	ftsk spoiiie
LPH64_RS02090	COG0492	ferredoxin-NADP+ reductase activity
LPH64_RS02100	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
LPH64_RS02105	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
LPH64_RS02110	COG0542	response to heat
LPH64_RS02130	COG2915	High frequency lysogenization protein hflD homolog
LPH64_RS02175	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LPH64_RS02185	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LPH64_RS02190	COG0047	phosphoribosylformylglycinamidine synthase activity
LPH64_RS02190	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LPH64_RS02200	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LPH64_RS02215	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
LPH64_RS02230	COG1137	ATPase activity
LPH64_RS02250	COG1660	Displays ATPase and GTPase activities
LPH64_RS02260	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LPH64_RS02265	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LPH64_RS02270	COG2239	Acts as a magnesium transporter
LPH64_RS02285	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LPH64_RS02310	COG1595	DNA-templated transcription, initiation
LPH64_RS02330	COG0142	geranyltranstransferase activity
LPH64_RS02340	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LPH64_RS02345	COG1845	cytochrome c oxidase, subunit III
LPH64_RS02350	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
LPH64_RS02355	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LPH64_RS02355	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LPH64_RS02365	COG1643	Atp-dependent helicase
LPH64_RS02370	COG0783	Belongs to the Dps family
LPH64_RS02375	COG0514	ATP-dependent DNA helicase (RecQ)
LPH64_RS02395	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LPH64_RS02435	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LPH64_RS02520	COG0142	geranyltranstransferase activity
LPH64_RS02525	COG1722	exodeoxyribonuclease VII activity
LPH64_RS02530	COG0037	tRNA processing
LPH64_RS02540	COG1301	dicarboxylic acid transport
LPH64_RS02545	COG0791	NLP P60 protein
LPH64_RS02550	COG0791	NLP P60 protein
LPH64_RS02560	COG2311	Membrane
LPH64_RS02585	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
LPH64_RS02600	COG0545	Peptidyl-prolyl cis-trans isomerase
LPH64_RS02605	COG0494	nUDIX hydrolase
LPH64_RS02615	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
LPH64_RS02630	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LPH64_RS02635	COG0352	thiamine-phosphate diphosphorylase activity
LPH64_RS02635	COG0351	phosphomethylpyrimidine kinase
LPH64_RS02660	COG1324	tolerance protein
LPH64_RS02695	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LPH64_RS02700	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LPH64_RS02705	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
LPH64_RS02720	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
LPH64_RS02740	COG4774	siderophore transport
LPH64_RS02765	COG1477	protein flavinylation
LPH64_RS02770	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
LPH64_RS02775	COG1555	photosystem II stabilization
LPH64_RS02785	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
LPH64_RS02795	COG0628	permease
LPH64_RS02805	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
LPH64_RS02810	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
LPH64_RS02830	COG3590	peptidase
LPH64_RS02835	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LPH64_RS02865	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LPH64_RS02885	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LPH64_RS02885	COG0519	Catalyzes the synthesis of GMP from XMP
LPH64_RS02890	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
LPH64_RS02895	COG1162	GTPase activity
LPH64_RS02905	COG3107	peptidoglycan biosynthetic process
LPH64_RS02930	COG2878	Part of a membrane complex involved in electron transport
LPH64_RS03025	COG1611	Belongs to the LOG family
LPH64_RS03030	COG4943	cyclic-guanylate-specific phosphodiesterase activity
LPH64_RS03040	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
LPH64_RS03045	COG1160	GTP binding
LPH64_RS03050	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LPH64_RS03080	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LPH64_RS03095	COG0330	HflC and HflK could
LPH64_RS03100	COG0330	HflC and HflK could
LPH64_RS03105	COG0604	alcohol dehydrogenase
LPH64_RS03135	COG1183	phosphatidylcholine synthase activity
LPH64_RS03145	COG0456	acetyltransferase
LPH64_RS03165	COG0668	transmembrane transport
LPH64_RS03170	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
LPH64_RS03185	COG1610	YqeY-like protein
LPH64_RS03190	COG1295	ribonuclease BN
LPH64_RS03195	COG0358	DNA primase activity
LPH64_RS03205	COG0180	Tryptophanyl-tRNA synthetase
LPH64_RS03215	COG1074	ATP-dependent DNA helicase activity
LPH64_RS03220	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
LPH64_RS03225	COG1127	ABC transporter
LPH64_RS03230	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LPH64_RS03235	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
LPH64_RS03250	COG2853	Lipoprotein
LPH64_RS03260	COG1116	anion transmembrane transporter activity
LPH64_RS03275	COG0531	amino acid
LPH64_RS03285	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
LPH64_RS03290	COG0861	Integral membrane protein TerC family
LPH64_RS03330	COG4999	Histidine kinase
LPH64_RS03330	COG3850	Histidine kinase
LPH64_RS03330	COG3437	response regulator, receiver
LPH64_RS03330	COG2205	protein histidine kinase activity
LPH64_RS03390	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LPH64_RS03440	COG2124	cytochrome p450
LPH64_RS03470	COG0305	Participates in initiation and elongation during chromosome replication
LPH64_RS03485	COG0667	Aldo Keto reductase
LPH64_RS03490	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
LPH64_RS03525	COG2194	sulfuric ester hydrolase activity
LPH64_RS03530	COG2124	cytochrome p450
LPH64_RS03535	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LPH64_RS03545	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LPH64_RS03555	COG0277	FAD linked oxidase domain protein
LPH64_RS03570	COG4206	TonB-dependent receptor
LPH64_RS03615	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
LPH64_RS03620	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
LPH64_RS03645	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LPH64_RS03665	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LPH64_RS03665	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LPH64_RS03685	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LPH64_RS03690	COG0488	(ABC) transporter
LPH64_RS03700	COG3011	Protein conserved in bacteria
LPH64_RS03710	COG0564	pseudouridine synthase activity
LPH64_RS03715	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LPH64_RS03735	COG1028	Short-chain dehydrogenase reductase Sdr
LPH64_RS03740	COG2969	positive regulation of protein catabolic process
LPH64_RS03745	COG0625	glutathione transferase activity
LPH64_RS03765	COG0741	lytic transglycosylase activity
LPH64_RS03775	COG1702	phosphate starvation-inducible protein PhoH
LPH64_RS03790	COG4535	Mg2 and Co2 transporter CorC
LPH64_RS03825	COG3210	domain, Protein
LPH64_RS03830	COG2831	hemolysin activation secretion protein
LPH64_RS03855	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
LPH64_RS03875	COG3115	cell septum assembly
LPH64_RS03890	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
LPH64_RS03900	COG0316	Belongs to the HesB IscA family
LPH64_RS03925	COG0167	dihydroorotate dehydrogenase activity
LPH64_RS03930	COG0812	UDP-N-acetylmuramate dehydrogenase activity
LPH64_RS03935	COG0697	spore germination
LPH64_RS03940	COG0671	phosphoesterase, PA-phosphatase related
LPH64_RS03945	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
LPH64_RS03955	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
LPH64_RS03960	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
LPH64_RS03980	COG1132	(ABC) transporter
LPH64_RS03995	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
LPH64_RS04000	COG1538	Outer membrane efflux protein
LPH64_RS04005	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LPH64_RS04015	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
LPH64_RS04030	COG4783	chaperone-mediated protein folding
LPH64_RS04040	COG0473	3-isopropylmalate dehydrogenase activity
LPH64_RS04050	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LPH64_RS04060	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
LPH64_RS04070	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
LPH64_RS04070	COG0316	Belongs to the HesB IscA family
LPH64_RS04075	COG2154	pterin-4-alpha-carbinolamine dehydratase
LPH64_RS04090	COG0564	pseudouridine synthase activity
LPH64_RS04095	COG1530	ribonuclease E activity
LPH64_RS04115	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
LPH64_RS04130	COG0488	(ABC) transporter
LPH64_RS04140	COG1278	Cold shock
LPH64_RS04155	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LPH64_RS04165	COG0049	tRNA binding
LPH64_RS04180	COG0085	RNA polymerase activity
LPH64_RS04185	COG0222	ribosome binding
LPH64_RS04200	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
LPH64_RS04205	COG0250	Participates in transcription elongation, termination and antitermination
LPH64_RS04210	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LPH64_RS04220	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LPH64_RS04240	COG0012	GTP binding
LPH64_RS04245	COG0193	aminoacyl-tRNA hydrolase activity
LPH64_RS04250	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
LPH64_RS04255	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LPH64_RS04265	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
LPH64_RS04270	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
LPH64_RS04280	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
LPH64_RS04355	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LPH64_RS04360	COG0765	amino acid transport
LPH64_RS04365	COG1126	abc transporter atp-binding protein
LPH64_RS04370	COG0765	amino acid transport
LPH64_RS04375	COG1074	ATP-dependent DNA helicase activity
LPH64_RS04385	COG2095	MarC family integral membrane protein
LPH64_RS04390	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
LPH64_RS04420	COG2132	Multicopper oxidase
LPH64_RS04430	COG0210	DNA helicase
LPH64_RS04440	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
LPH64_RS04445	COG0616	signal peptide processing
LPH64_RS04465	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
LPH64_RS04470	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LPH64_RS04475	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
LPH64_RS04485	COG2177	Part of the ABC transporter FtsEX involved in
LPH64_RS04490	COG2884	Cell division ATP-binding protein ftsE
LPH64_RS04495	COG0513	Belongs to the DEAD box helicase family
LPH64_RS04500	COG3118	belongs to the thioredoxin family
LPH64_RS04505	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
LPH64_RS04530	COG0793	Belongs to the peptidase S41A family
LPH64_RS04535	COG4942	peptidase
LPH64_RS04545	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
LPH64_RS04565	COG0493	'glutamate synthase
LPH64_RS04570	COG0067	glutamate synthase
LPH64_RS04570	COG0069	glutamate synthase activity
LPH64_RS04570	COG0070	glutamate synthase
LPH64_RS04670	COG3210	domain, Protein
LPH64_RS04805	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
LPH64_RS04815	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
LPH64_RS04820	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
LPH64_RS04940	COG1028	Short-chain dehydrogenase reductase Sdr
LPH64_RS04960	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LPH64_RS04970	COG1199	ATP-dependent helicase activity
LPH64_RS04980	COG0288	reversible hydration of carbon dioxide
LPH64_RS04985	COG0438	transferase activity, transferring glycosyl groups
LPH64_RS05000	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LPH64_RS05005	COG2011	ABC-type metal ion transport system permease component
LPH64_RS05010	COG1464	Belongs to the NlpA lipoprotein family
LPH64_RS05025	COG0508	dehydrogenase complex catalyzes the overall conversion of
LPH64_RS05030	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LPH64_RS05045	COG0626	cystathionine gamma-synthase activity
LPH64_RS05050	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LPH64_RS05055	COG0739	heme binding
LPH64_RS05060	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
LPH64_RS05065	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
LPH64_RS05090	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LPH64_RS05115	COG3525	Glycosyl hydrolase, family 20, catalytic domain
LPH64_RS05125	COG1472	Belongs to the glycosyl hydrolase 3 family
LPH64_RS05140	COG3537	Alpha-1,2-mannosidase
LPH64_RS05160	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
LPH64_RS05170	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LPH64_RS05175	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LPH64_RS05180	COG2207	Transcriptional regulator
LPH64_RS05185	COG2249	NAD(P)H dehydrogenase (quinone) activity
LPH64_RS05215	COG3588	fructose-bisphosphate aldolase
LPH64_RS05230	COG0469	pyruvate kinase activity
LPH64_RS05250	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LPH64_RS05255	COG0735	belongs to the Fur family
LPH64_RS05270	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
LPH64_RS05270	COG5297	Belongs to the glycosyl hydrolase family 6
LPH64_RS05280	COG0612	Peptidase, M16
LPH64_RS05300	COG0653	protein targeting
LPH64_RS05305	COG0739	heme binding
LPH64_RS05315	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
LPH64_RS05330	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
LPH64_RS05335	COG1181	Belongs to the D-alanine--D-alanine ligase family
LPH64_RS05340	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LPH64_RS05355	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LPH64_RS05360	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LPH64_RS05375	COG3116	cell division
LPH64_RS05380	COG0275	rRNA processing
LPH64_RS05390	COG0471	metal ion transport
LPH64_RS05390	COG3273	potassium ion transport
LPH64_RS05395	COG0220	tRNA (guanine-N7-)-methyltransferase activity
LPH64_RS05440	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LPH64_RS05465	COG0717	Belongs to the dCTP deaminase family
LPH64_RS05480	COG0860	N-Acetylmuramoyl-L-alanine amidase
LPH64_RS05485	COG0802	atpase or kinase
LPH64_RS05490	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
LPH64_RS05490	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
LPH64_RS05495	COG1570	exodeoxyribonuclease VII activity
LPH64_RS05540	COG0776	regulation of translation
LPH64_RS05545	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LPH64_RS05545	COG0072	phenylalanine-tRNA ligase activity
LPH64_RS05550	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
LPH64_RS05555	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
LPH64_RS05565	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
LPH64_RS05595	COG0745	RESPONSE REGULATOR receiver
LPH64_RS05610	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
LPH64_RS05660	COG0045	succinate-CoA ligase (ADP-forming) activity
LPH64_RS05665	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
LPH64_RS05670	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
LPH64_RS05685	COG0594	ribonuclease P activity
LPH64_RS05695	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LPH64_RS05705	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
LPH64_RS05710	COG0187	DNA topoisomerase II activity
LPH64_RS05720	COG0501	Belongs to the peptidase M48B family
LPH64_RS05765	COG0408	coproporphyrinogen oxidase activity
LPH64_RS05790	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LPH64_RS05860	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
LPH64_RS05870	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
LPH64_RS05880	COG0511	ligase activity, forming carbon-carbon bonds
LPH64_RS05885	COG0439	Biotin carboxylase
LPH64_RS05890	COG0210	DNA helicase
LPH64_RS05925	COG1040	competence protein
LPH64_RS05930	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
LPH64_RS05935	COG1752	Esterase of the alpha-beta hydrolase superfamily
LPH64_RS05940	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
LPH64_RS05960	COG2027	D-alanyl-D-alanine carboxypeptidase
LPH64_RS05995	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LPH64_RS06005	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
LPH64_RS06030	COG3121	Chaperone
LPH64_RS06035	COG3539	Fimbrial protein
LPH64_RS06040	COG1546	Belongs to the CinA family
LPH64_RS06045	COG0477	Major facilitator Superfamily
LPH64_RS06050	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LPH64_RS06055	COG1923	regulation of RNA biosynthetic process
LPH64_RS06065	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
LPH64_RS06070	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LPH64_RS06080	COG1534	Rna-binding protein
LPH64_RS06095	COG0129	dihydroxy-acid dehydratase activity
LPH64_RS06125	COG1560	Kdo2-lipid A biosynthetic process
LPH64_RS06130	COG1519	Transferase
LPH64_RS06145	COG0228	four-way junction DNA binding
LPH64_RS06150	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
LPH64_RS06155	COG0336	Belongs to the RNA methyltransferase TrmD family
LPH64_RS06160	COG0335	large ribosomal subunit rRNA binding
LPH64_RS06180	COG1393	Belongs to the ArsC family
LPH64_RS06190	COG0367	asparagine synthase
LPH64_RS06200	COG2070	2-Nitropropane dioxygenase
LPH64_RS06220	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LPH64_RS06235	COG0339	signal peptide processing
LPH64_RS06260	COG0525	valine-tRNA ligase activity
LPH64_RS06300	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LPH64_RS06325	COG4221	oxidoreductase activity
LPH64_RS06335	COG0018	arginyl-trna synthetase
LPH64_RS06340	COG2003	Belongs to the UPF0758 family
LPH64_RS06345	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
LPH64_RS06415	COG2223	nitrite transmembrane transporter activity
LPH64_RS06420	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
LPH64_RS06425	COG0739	heme binding
LPH64_RS06430	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
LPH64_RS06460	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LPH64_RS06485	COG1028	Short-chain dehydrogenase reductase Sdr
LPH64_RS06495	COG1272	protein, Hemolysin III
LPH64_RS06500	COG0463	Glycosyl transferase, family 2
LPH64_RS06505	COG0084	hydrolase, TatD family'
LPH64_RS06520	COG0509	glycine decarboxylation via glycine cleavage system
LPH64_RS06525	COG0404	The glycine cleavage system catalyzes the degradation of glycine
LPH64_RS06535	COG0330	HflC and HflK could
LPH64_RS06540	COG3956	TIGRFAM MazG family protein
LPH64_RS06545	COG1218	3'(2'),5'-bisphosphate nucleotidase
LPH64_RS06550	COG0494	nUDIX hydrolase
LPH64_RS06560	COG1385	rRNA (uridine-N3-)-methyltransferase activity
LPH64_RS06570	COG0513	Belongs to the DEAD box helicase family
LPH64_RS06575	COG0720	synthase
LPH64_RS06600	COG1981	membrane
LPH64_RS06610	COG0587	DNA-directed DNA polymerase activity
LPH64_RS06620	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
LPH64_RS06625	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LPH64_RS06640	COG0512	Glutamine amidotransferase of anthranilate synthase
LPH64_RS06645	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LPH64_RS06685	COG0006	proline dipeptidase activity
LPH64_RS06705	COG1862	Preprotein translocase
LPH64_RS06710	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LPH64_RS06715	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LPH64_RS06725	COG0617	tRNA 3'-terminal CCA addition
LPH64_RS06740	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
LPH64_RS06745	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
LPH64_RS06750	COG0166	Belongs to the GPI family
LPH64_RS06760	COG0779	Required for maturation of 30S ribosomal subunits
LPH64_RS06765	COG0195	Participates in both transcription termination and antitermination
LPH64_RS06770	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
LPH64_RS06775	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
LPH64_RS06780	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
LPH64_RS06790	COG1185	polyribonucleotide nucleotidyltransferase activity
LPH64_RS06795	COG1733	regulation of RNA biosynthetic process
LPH64_RS06800	COG0702	epimerase
LPH64_RS06815	COG0475	glutathione-regulated potassium exporter activity
LPH64_RS06845	COG2086	electron transfer activity
LPH64_RS06875	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LPH64_RS06935	COG0477	Major facilitator Superfamily
LPH64_RS06960	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LPH64_RS06965	COG0671	phosphoesterase, PA-phosphatase related
LPH64_RS06995	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LPH64_RS07005	COG0628	permease
LPH64_RS07025	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LPH64_RS07030	COG1090	epimerase
LPH64_RS07035	COG0318	PFAM AMP-dependent synthetase and ligase
LPH64_RS07055	COG1049	propionate catabolic process, 2-methylcitrate cycle
LPH64_RS07070	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
LPH64_RS07075	COG0732	type I restriction modification DNA specificity domain
LPH64_RS07090	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
LPH64_RS07125	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LPH64_RS07135	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LPH64_RS07145	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
LPH64_RS07150	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
LPH64_RS07155	COG1034	ATP synthesis coupled electron transport
LPH64_RS07190	COG1007	ATP synthesis coupled electron transport
LPH64_RS07195	COG1028	Short-chain dehydrogenase reductase Sdr
LPH64_RS07200	COG2851	Citrate transporter
LPH64_RS07215	COG0642	Histidine kinase
LPH64_RS07230	COG0784	Response regulator, receiver
LPH64_RS07230	COG2198	Histidine kinase
LPH64_RS07230	COG2205	protein histidine kinase activity
LPH64_RS07240	COG1301	dicarboxylic acid transport
LPH64_RS07245	COG0280	phosphate acetyltransferase
LPH64_RS07245	COG0281	malic enzyme
LPH64_RS07255	COG0742	ribosomal rna small subunit methyltransferase
LPH64_RS07270	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
LPH64_RS07290	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LPH64_RS07295	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
LPH64_RS07330	COG2166	iron-sulfur cluster assembly
LPH64_RS07335	COG0215	cysteine-tRNA ligase activity
LPH64_RS07355	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LPH64_RS07375	COG0165	Argininosuccinate lyase
LPH64_RS07390	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
LPH64_RS07425	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
LPH64_RS07485	COG5314	conjugation
LPH64_RS07510	COG1233	COG1233 Phytoene dehydrogenase and related
LPH64_RS07520	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LPH64_RS07535	COG1028	Short-chain dehydrogenase reductase Sdr
LPH64_RS07555	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
LPH64_RS07635	COG1914	H( )-stimulated, divalent metal cation uptake system
LPH64_RS07650	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
LPH64_RS07660	COG1946	Acyl-CoA thioesterase
LPH64_RS07740	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LPH64_RS07755	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LPH64_RS07775	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
LPH64_RS07780	COG0575	Belongs to the CDS family
LPH64_RS07820	COG2833	Protein of unknown function (DUF455)
LPH64_RS07825	COG0528	UMP kinase activity
LPH64_RS07895	COG0800	Aldolase
LPH64_RS07905	COG0363	glucosamine-6-phosphate deaminase activity
LPH64_RS07910	COG0837	glucose binding
LPH64_RS07915	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
LPH64_RS07920	COG3842	ATPase activity
LPH64_RS07940	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
LPH64_RS07955	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
LPH64_RS07965	COG4591	ABC-type transport system involved in lipoprotein release permease component
LPH64_RS07970	COG1136	(ABC) transporter
LPH64_RS07975	COG2333	competence protein COMEC
LPH64_RS07975	COG0658	competence protein
LPH64_RS07995	COG1663	tetraacyldisaccharide 4'-kinase activity
LPH64_RS08000	COG0489	protein tyrosine kinase activity
LPH64_RS08005	COG2062	phosphohistidine phosphatase, SixA
LPH64_RS08015	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LPH64_RS08060	COG0009	L-threonylcarbamoyladenylate synthase
LPH64_RS08065	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LPH64_RS08065	COG1754	DNA topoisomerase type I activity
LPH64_RS08075	COG2922	Belongs to the Smg family
LPH64_RS08080	COG0758	DNA mediated transformation
LPH64_RS08095	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LPH64_RS08105	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
LPH64_RS08170	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LPH64_RS08245	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
LPH64_RS08250	COG0505	Belongs to the CarA family
LPH64_RS08255	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LPH64_RS08260	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LPH64_RS08270	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
LPH64_RS08280	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
LPH64_RS08295	COG1024	Enoyl-CoA hydratase
LPH64_RS08300	COG0527	aspartate kinase activity
LPH64_RS08310	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
LPH64_RS08330	COG0494	nUDIX hydrolase
LPH64_RS08340	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
LPH64_RS08365	COG0312	modulator of DNA gyrase
LPH64_RS08370	COG3028	Belongs to the UPF0307 family
LPH64_RS08375	COG0312	modulator of DNA gyrase
LPH64_RS08405	COG0583	DNA-binding transcription factor activity
LPH64_RS08420	COG1064	alcohol dehydrogenase
LPH64_RS08435	COG0667	Aldo Keto reductase
LPH64_RS08465	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
LPH64_RS08495	COG0356	it plays a direct role in the translocation of protons across the membrane
LPH64_RS08520	COG0089	rRNA binding
LPH64_RS08530	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
LPH64_RS08535	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
LPH64_RS08540	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
LPH64_RS08600	COG1841	ribosomal large subunit assembly
LPH64_RS08605	COG0200	Binds to the 23S rRNA
LPH64_RS08610	COG0201	protein transport
LPH64_RS08615	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
LPH64_RS08620	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
LPH64_RS08640	COG2960	long-chain fatty acid transporting porin activity
LPH64_RS08645	COG0606	chelatase, subunit chli
LPH64_RS08650	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
LPH64_RS08665	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
LPH64_RS08680	COG0544	peptidyl-prolyl cis-trans isomerase activity
LPH64_RS08685	COG0740	serine-type endopeptidase activity
LPH64_RS08690	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
LPH64_RS08725	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LPH64_RS08730	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LPH64_RS08760	COG1187	pseudouridine synthase activity
LPH64_RS08765	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LPH64_RS08785	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LPH64_RS08820	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LPH64_RS08820	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LPH64_RS08840	COG3772	lysozyme
LPH64_RS08880	COG0625	glutathione transferase activity
LPH64_RS08890	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LPH64_RS08895	COG1217	gtp-binding protein TYPA
LPH64_RS08940	COG0842	Transport permease protein
LPH64_RS08945	COG1131	(ABC) transporter
LPH64_RS08965	COG1643	Atp-dependent helicase
LPH64_RS08975	COG1956	GAF domain-containing protein
LPH64_RS08980	COG0729	surface antigen
LPH64_RS08985	COG2911	Protein conserved in bacteria
LPH64_RS09035	COG1937	Protein conserved in bacteria
LPH64_RS09070	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
LPH64_RS09075	COG0668	transmembrane transport
LPH64_RS09105	COG2733	membrane
LPH64_RS09120	COG2921	Belongs to the UPF0250 family
LPH64_RS09125	COG0321	lipoyl(octanoyl) transferase activity
LPH64_RS09130	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
LPH64_RS09160	COG1253	flavin adenine dinucleotide binding
LPH64_RS09185	COG0504	CTP synthase activity
LPH64_RS09190	COG2877	3-deoxy-8-phosphooctulonate synthase activity
LPH64_RS09195	COG0148	phosphopyruvate hydratase activity
LPH64_RS09210	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
LPH64_RS09215	COG2840	Smr protein MutS2
LPH64_RS09225	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
LPH64_RS09225	COG0644	oxidoreductase
LPH64_RS09240	COG3218	ABC-type transport auxiliary lipoprotein component
LPH64_RS09240	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
LPH64_RS09245	COG1127	ABC transporter
LPH64_RS09250	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LPH64_RS09315	COG1077	Cell shape determining protein MreB Mrl
LPH64_RS09325	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
LPH64_RS09330	COG0768	penicillin binding
LPH64_RS09335	COG0772	Belongs to the SEDS family
LPH64_RS09345	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LPH64_RS09365	COG2894	cell division
LPH64_RS09370	COG0850	regulation of cytokinetic process
LPH64_RS09390	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
LPH64_RS09400	COG3038	cytochrome b561
LPH64_RS09405	COG2353	YceI-like domain
LPH64_RS09410	COG5002	protein histidine kinase activity
LPH64_RS09410	COG0784	Response regulator, receiver
LPH64_RS09420	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
LPH64_RS09445	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LPH64_RS09475	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
LPH64_RS09480	COG4208	sulfate ABC transporter
LPH64_RS09605	COG5532	Uncharacterized conserved protein (DUF2303)
LPH64_RS09630	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LPH64_RS09655	COG1566	PFAM secretion protein HlyD family protein
LPH64_RS09660	COG2814	Major facilitator Superfamily
LPH64_RS09665	COG2267	carboxylic ester hydrolase activity
LPH64_RS09685	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LPH64_RS09690	COG0617	tRNA 3'-terminal CCA addition
LPH64_RS09695	COG0741	lytic transglycosylase activity
LPH64_RS09770	COG1028	Short-chain dehydrogenase reductase Sdr
LPH64_RS09785	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
LPH64_RS09790	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
LPH64_RS09810	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
LPH64_RS09815	COG0483	inositol monophosphate 1-phosphatase activity
LPH64_RS09825	COG1509	lysine 2,3-aminomutase activity
LPH64_RS09835	COG0402	S-adenosylhomocysteine deaminase activity
LPH64_RS09840	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LPH64_RS09845	COG0546	phosphoglycolate phosphatase activity
LPH64_RS09860	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LPH64_RS09895	COG0436	Aminotransferase
LPH64_RS09910	COG1187	pseudouridine synthase activity
LPH64_RS09915	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
LPH64_RS09920	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
LPH64_RS09955	COG0395	ABC-type sugar transport system, permease component
LPH64_RS09970	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LPH64_RS09975	COG2957	Belongs to the agmatine deiminase family
LPH64_RS10000	COG0776	regulation of translation
LPH64_RS10010	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
LPH64_RS10025	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LPH64_RS10030	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
LPH64_RS10105	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LPH64_RS10115	COG0211	Belongs to the bacterial ribosomal protein bL27 family
LPH64_RS10120	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
LPH64_RS10125	COG0268	Binds directly to 16S ribosomal RNA
LPH64_RS10130	COG0728	peptidoglycan biosynthetic process
LPH64_RS10135	COG0196	riboflavin kinase activity
LPH64_RS10140	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
LPH64_RS10165	COG1396	sequence-specific DNA binding
LPH64_RS10220	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LPH64_RS10220	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
LPH64_RS10295	COG0436	Aminotransferase
LPH64_RS10305	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
LPH64_RS10325	COG1902	pentaerythritol trinitrate reductase activity
LPH64_RS10335	COG1335	isochorismatase
LPH64_RS10345	COG1064	alcohol dehydrogenase
LPH64_RS10350	COG0604	alcohol dehydrogenase
LPH64_RS10375	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LPH64_RS10380	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LPH64_RS10410	COG0473	3-isopropylmalate dehydrogenase activity
LPH64_RS10440	COG0438	transferase activity, transferring glycosyl groups
LPH64_RS10450	COG2244	polysaccharide biosynthetic process
LPH64_RS10455	COG0438	transferase activity, transferring glycosyl groups
LPH64_RS10470	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LPH64_RS10475	COG2954	triphosphatase activity
LPH64_RS10480	COG1472	Belongs to the glycosyl hydrolase 3 family
LPH64_RS10485	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
LPH64_RS10495	COG1278	Cold shock
LPH64_RS10520	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LPH64_RS10530	COG0497	DNA recombination
LPH64_RS10545	COG0443	Heat shock 70 kDa protein
LPH64_RS10550	COG0484	heat shock protein binding
LPH64_RS10565	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
LPH64_RS10575	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
LPH64_RS10595	COG0745	RESPONSE REGULATOR receiver
LPH64_RS10600	COG2205	protein histidine kinase activity
LPH64_RS10610	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
LPH64_RS10615	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
LPH64_RS10635	COG2967	ApaG domain
LPH64_RS10645	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LPH64_RS10650	COG0704	Plays a role in the regulation of phosphate uptake
LPH64_RS10660	COG0581	inorganic phosphate transmembrane transporter activity
LPH64_RS10665	COG0573	inorganic phosphate transmembrane transporter activity
LPH64_RS10670	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
LPH64_RS10675	COG4651	solute:proton antiporter activity
LPH64_RS10675	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LPH64_RS10685	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
LPH64_RS10695	COG0488	(ABC) transporter
LPH64_RS10720	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LPH64_RS10730	COG0489	protein tyrosine kinase activity
LPH64_RS10755	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LPH64_RS10810	COG1469	GTP cyclohydrolase I activity
LPH64_RS10820	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LPH64_RS10825	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LPH64_RS10830	COG2902	Dehydrogenase
LPH64_RS10835	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
LPH64_RS10865	COG2925	Exonuclease
LPH64_RS10885	COG0025	NhaP-type Na H and K H
LPH64_RS10905	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LPH64_RS10925	COG3079	Belongs to the UPF0149 family
LPH64_RS10930	COG0006	proline dipeptidase activity
LPH64_RS10970	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LPH64_RS11030	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LPH64_RS11055	COG3772	lysozyme
LPH64_RS11075	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LPH64_RS11075	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LPH64_RS11115	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LPH64_RS11125	COG0328	RNA-DNA hybrid ribonuclease activity
LPH64_RS11130	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LPH64_RS11150	COG0859	PFAM glycosyl transferase family 9
LPH64_RS11160	COG2943	transferase activity, transferring hexosyl groups
LPH64_RS11165	COG0400	carboxylic ester hydrolase activity
LPH64_RS11170	COG3275	phosphorelay sensor kinase activity
LPH64_RS11215	COG0463	Glycosyl transferase, family 2
LPH64_RS11225	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LPH64_RS11240	COG0392	lysyltransferase activity
LPH64_RS11240	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
LPH64_RS11245	COG0251	oxidation-reduction process
LPH64_RS11260	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
LPH64_RS11265	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LPH64_RS11270	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
LPH64_RS11275	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
LPH64_RS11295	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
LPH64_RS11345	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LPH64_RS11455	COG0582	viral genome integration into host DNA
LPH64_RS11470	COG3772	lysozyme
LPH64_RS11525	COG0640	Transcriptional regulator
LPH64_RS11540	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LPH64_RS11565	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LPH64_RS11600	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
LPH64_RS11605	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
LPH64_RS11615	COG0537	adenosine 5'-monophosphoramidase activity
LPH64_RS11635	COG0714	Associated with various cellular activities
LPH64_RS11645	COG1399	metal-binding, possibly nucleic acid-binding protein
LPH64_RS11650	COG0333	Belongs to the bacterial ribosomal protein bL32 family
LPH64_RS11655	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LPH64_RS11670	COG5297	Belongs to the glycosyl hydrolase family 6
LPH64_RS11675	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LPH64_RS11695	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
LPH64_RS11705	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LPH64_RS11710	COG1764	response to oxidative stress
LPH64_RS11715	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
LPH64_RS11720	COG2945	thiolester hydrolase activity
LPH64_RS11780	COG2353	YceI-like domain
LPH64_RS11785	COG1968	undecaprenyl-diphosphatase activity
LPH64_RS11790	COG0174	glutamine synthetase
LPH64_RS11795	COG0347	Belongs to the P(II) protein family
LPH64_RS11800	COG0004	ammonium transporteR
LPH64_RS11830	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
LPH64_RS11835	COG0084	hydrolase, TatD family'
LPH64_RS11920	COG1487	ribonuclease activity