locus-tag	class	description
LPH50_RS00015	COG0552	protein localization to endoplasmic reticulum
LPH50_RS00035	COG0217	transcriptional regulatory protein
LPH50_RS00050	COG3158	transport of potassium into the cell
LPH50_RS00060	COG0824	Thioesterase
LPH50_RS00065	COG0811	peptide transport
LPH50_RS00070	COG0848	biopolymer transport protein
LPH50_RS00085	COG2885	chlorophyll binding
LPH50_RS00095	COG0602	queuosine metabolic process
LPH50_RS00105	COG1515	deoxyribonuclease V activity
LPH50_RS00115	COG0386	Belongs to the glutathione peroxidase family
LPH50_RS00125	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
LPH50_RS00135	COG0406	alpha-ribazole phosphatase activity
LPH50_RS00145	COG3041	Addiction module toxin RelE StbE family
LPH50_RS00150	COG3077	Addiction module antitoxin, RelB DinJ family
LPH50_RS00225	COG2337	Toxic component of a toxin-antitoxin (TA) module
LPH50_RS00285	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
LPH50_RS00330	COG2091	lysine biosynthetic process via aminoadipic acid
LPH50_RS00340	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
LPH50_RS00345	COG1301	dicarboxylic acid transport
LPH50_RS00370	COG0339	signal peptide processing
LPH50_RS00380	COG0285	dihydrofolate synthase activity
LPH50_RS00405	COG2201	protein-glutamate methylesterase activity
LPH50_RS00410	COG0643	Histidine kinase
LPH50_RS00410	COG0784	Response regulator, receiver
LPH50_RS00410	COG2198	Histidine kinase
LPH50_RS00415	COG0840	transmembrane signaling receptor activity
LPH50_RS00445	COG0751	glycine-tRNA ligase activity
LPH50_RS00455	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LPH50_RS00455	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
LPH50_RS00480	COG0727	PFAM Uncharacterised protein family (UPF0153)
LPH50_RS00495	COG0596	Alpha beta hydrolase
LPH50_RS00505	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LPH50_RS00515	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
LPH50_RS00525	COG0138	bifunctional purine biosynthesis protein purh
LPH50_RS00530	COG0151	Belongs to the GarS family
LPH50_RS00550	COG1289	transmembrane transporter activity
LPH50_RS00560	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
LPH50_RS00570	COG0302	gtp cyclohydrolase
LPH50_RS00580	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
LPH50_RS00590	COG0557	exoribonuclease II activity
LPH50_RS00600	COG3772	lysozyme
LPH50_RS00695	COG1881	PFAM PEBP family protein
LPH50_RS00700	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
LPH50_RS00705	COG3118	belongs to the thioredoxin family
LPH50_RS00715	COG0495	leucyl-tRNA aminoacylation
LPH50_RS00745	COG2951	lytic endotransglycosylase activity
LPH50_RS00890	COG3210	domain, Protein
LPH50_RS00990	COG3210	domain, Protein
LPH50_RS01005	COG1280	lysine exporter protein (LysE YggA)
LPH50_RS01025	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LPH50_RS01030	COG0277	FAD linked oxidase domain protein
LPH50_RS01035	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LPH50_RS01040	COG0531	amino acid
LPH50_RS01045	COG0531	amino acid
LPH50_RS01050	COG0235	Class ii aldolase
LPH50_RS01055	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
LPH50_RS01060	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
LPH50_RS01105	COG0131	Imidazoleglycerol-phosphate dehydratase
LPH50_RS01105	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
LPH50_RS01115	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
LPH50_RS01120	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
LPH50_RS01140	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
LPH50_RS01145	COG0083	homoserine kinase activity
LPH50_RS01150	COG0527	aspartate kinase activity
LPH50_RS01150	COG0460	homoserine dehydrogenase
LPH50_RS01160	COG0540	Belongs to the ATCase OTCase family
LPH50_RS01175	COG1686	Belongs to the peptidase S11 family
LPH50_RS01180	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
LPH50_RS01195	COG4953	penicillin-binding protein 1C
LPH50_RS01230	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LPH50_RS01255	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
LPH50_RS01260	COG1381	Involved in DNA repair and RecF pathway recombination
LPH50_RS01275	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LPH50_RS01285	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LPH50_RS01295	COG1028	Short-chain dehydrogenase reductase Sdr
LPH50_RS01310	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LPH50_RS01315	COG0823	Involved in the tonB-independent uptake of proteins
LPH50_RS01315	COG1506	peptidase
LPH50_RS01320	COG1297	OPT oligopeptide transporter protein
LPH50_RS01355	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
LPH50_RS01365	COG0318	PFAM AMP-dependent synthetase and ligase
LPH50_RS01375	COG0463	Glycosyl transferase, family 2
LPH50_RS01385	COG1475	DNA binding
LPH50_RS01390	COG1192	Involved in chromosome partitioning
LPH50_RS01405	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
LPH50_RS01420	COG1605	Chorismate mutase
LPH50_RS01420	COG0077	Prephenate dehydratase
LPH50_RS01435	COG1668	transmembrane transport
LPH50_RS01440	COG4555	ABC transporter
LPH50_RS01470	COG1309	transcriptional regulator
LPH50_RS01475	COG2226	methyltransferase
LPH50_RS01485	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LPH50_RS01500	COG2900	Belongs to the SlyX family
LPH50_RS01515	COG0386	Belongs to the glutathione peroxidase family
LPH50_RS01525	COG1131	(ABC) transporter
LPH50_RS01550	COG2850	peptidyl-arginine hydroxylation
LPH50_RS01555	COG0567	Dehydrogenase, E1 component
LPH50_RS01575	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
LPH50_RS01600	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
LPH50_RS01630	COG0583	DNA-binding transcription factor activity
LPH50_RS01635	COG3634	alkyl hydroperoxide reductase activity
LPH50_RS01645	COG5295	Hep Hag repeat protein
LPH50_RS01650	COG1450	Type ii and iii secretion system protein
LPH50_RS01665	COG3166	PFAM Fimbrial assembly family protein
LPH50_RS01670	COG3156	type II secretion system protein K
LPH50_RS01680	COG3156	type II secretion system protein K
LPH50_RS01685	COG4795	General secretion pathway protein
LPH50_RS01690	COG2165	general secretion pathway protein
LPH50_RS01695	COG4970	Tfp pilus assembly protein FimT
LPH50_RS01700	COG2165	general secretion pathway protein
LPH50_RS01705	COG1459	type II secretion system
LPH50_RS01710	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LPH50_RS01755	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LPH50_RS01770	COG1561	YicC-like family, N-terminal region
LPH50_RS01775	COG0194	GDP metabolic process
LPH50_RS01780	COG1758	RNA polymerase activity
LPH50_RS01785	COG2895	sulfate adenylyltransferase (ATP) activity
LPH50_RS01785	COG0529	Catalyzes the synthesis of activated sulfate
LPH50_RS01790	COG0175	sulfate reduction
LPH50_RS01805	COG0175	sulfate reduction
LPH50_RS01865	COG0308	aminopeptidase N
LPH50_RS01870	COG2226	methyltransferase
LPH50_RS01925	COG1959	2 iron, 2 sulfur cluster binding
LPH50_RS01930	COG0719	Fe-S assembly protein
LPH50_RS01935	COG0396	ATPase activity
LPH50_RS01940	COG0719	Fe-S assembly protein
LPH50_RS01945	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LPH50_RS01950	COG2146	nitrite reductase [NAD(P)H] activity
LPH50_RS01955	COG0297	glycogen (starch) synthase activity
LPH50_RS01960	COG0726	polysaccharide deacetylase
LPH50_RS01965	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LPH50_RS01970	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
LPH50_RS01990	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
LPH50_RS01995	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LPH50_RS02015	COG0837	glucose binding
LPH50_RS02040	COG4191	Histidine kinase
LPH50_RS02060	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LPH50_RS02065	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
LPH50_RS02080	COG1674	ftsk spoiiie
LPH50_RS02085	COG0492	ferredoxin-NADP+ reductase activity
LPH50_RS02095	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
LPH50_RS02100	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
LPH50_RS02105	COG0542	response to heat
LPH50_RS02125	COG2915	High frequency lysogenization protein hflD homolog
LPH50_RS02170	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LPH50_RS02180	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LPH50_RS02185	COG0047	phosphoribosylformylglycinamidine synthase activity
LPH50_RS02185	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LPH50_RS02195	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LPH50_RS02210	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
LPH50_RS02225	COG1137	ATPase activity
LPH50_RS02245	COG1660	Displays ATPase and GTPase activities
LPH50_RS02255	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LPH50_RS02260	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LPH50_RS02265	COG2239	Acts as a magnesium transporter
LPH50_RS02280	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LPH50_RS02305	COG1595	DNA-templated transcription, initiation
LPH50_RS02325	COG0142	geranyltranstransferase activity
LPH50_RS02335	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LPH50_RS02340	COG1845	cytochrome c oxidase, subunit III
LPH50_RS02345	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
LPH50_RS02350	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LPH50_RS02350	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LPH50_RS02360	COG1643	Atp-dependent helicase
LPH50_RS02365	COG0783	Belongs to the Dps family
LPH50_RS02370	COG0514	ATP-dependent DNA helicase (RecQ)
LPH50_RS02390	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LPH50_RS02430	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LPH50_RS02515	COG0142	geranyltranstransferase activity
LPH50_RS02520	COG1722	exodeoxyribonuclease VII activity
LPH50_RS02525	COG0037	tRNA processing
LPH50_RS02535	COG1301	dicarboxylic acid transport
LPH50_RS02540	COG0791	NLP P60 protein
LPH50_RS02545	COG0791	NLP P60 protein
LPH50_RS02555	COG2311	Membrane
LPH50_RS02585	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
LPH50_RS02600	COG0545	Peptidyl-prolyl cis-trans isomerase
LPH50_RS02605	COG0494	nUDIX hydrolase
LPH50_RS02615	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
LPH50_RS02630	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LPH50_RS02635	COG0352	thiamine-phosphate diphosphorylase activity
LPH50_RS02635	COG0351	phosphomethylpyrimidine kinase
LPH50_RS02655	COG1324	tolerance protein
LPH50_RS02690	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LPH50_RS02695	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LPH50_RS02700	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
LPH50_RS02715	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
LPH50_RS02735	COG4774	siderophore transport
LPH50_RS02760	COG1477	protein flavinylation
LPH50_RS02765	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
LPH50_RS02770	COG1555	photosystem II stabilization
LPH50_RS02780	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
LPH50_RS02790	COG0628	permease
LPH50_RS02800	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
LPH50_RS02805	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
LPH50_RS02825	COG3590	peptidase
LPH50_RS02830	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LPH50_RS02860	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LPH50_RS02880	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LPH50_RS02880	COG0519	Catalyzes the synthesis of GMP from XMP
LPH50_RS02885	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
LPH50_RS02890	COG1162	GTPase activity
LPH50_RS02900	COG3107	peptidoglycan biosynthetic process
LPH50_RS02925	COG2878	Part of a membrane complex involved in electron transport
LPH50_RS03020	COG1611	Belongs to the LOG family
LPH50_RS03025	COG4943	cyclic-guanylate-specific phosphodiesterase activity
LPH50_RS03035	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
LPH50_RS03040	COG1160	GTP binding
LPH50_RS03045	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LPH50_RS03075	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LPH50_RS03090	COG0330	HflC and HflK could
LPH50_RS03095	COG0330	HflC and HflK could
LPH50_RS03100	COG0604	alcohol dehydrogenase
LPH50_RS03130	COG1183	phosphatidylcholine synthase activity
LPH50_RS03140	COG0456	acetyltransferase
LPH50_RS03160	COG0668	transmembrane transport
LPH50_RS03165	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
LPH50_RS03180	COG1610	YqeY-like protein
LPH50_RS03185	COG1295	ribonuclease BN
LPH50_RS03190	COG0358	DNA primase activity
LPH50_RS03200	COG0180	Tryptophanyl-tRNA synthetase
LPH50_RS03210	COG1074	ATP-dependent DNA helicase activity
LPH50_RS03215	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
LPH50_RS03220	COG1127	ABC transporter
LPH50_RS03225	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LPH50_RS03230	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
LPH50_RS03245	COG2853	Lipoprotein
LPH50_RS03255	COG1116	anion transmembrane transporter activity
LPH50_RS03270	COG0531	amino acid
LPH50_RS03280	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
LPH50_RS03285	COG0861	Integral membrane protein TerC family
LPH50_RS03320	COG4999	Histidine kinase
LPH50_RS03320	COG3850	Histidine kinase
LPH50_RS03320	COG3437	response regulator, receiver
LPH50_RS03320	COG2205	protein histidine kinase activity
LPH50_RS03380	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LPH50_RS03435	COG2124	cytochrome p450
LPH50_RS03465	COG0305	Participates in initiation and elongation during chromosome replication
LPH50_RS03480	COG0667	Aldo Keto reductase
LPH50_RS03485	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
LPH50_RS03520	COG2194	sulfuric ester hydrolase activity
LPH50_RS03525	COG2124	cytochrome p450
LPH50_RS03530	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LPH50_RS03540	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LPH50_RS03550	COG0277	FAD linked oxidase domain protein
LPH50_RS03565	COG4206	TonB-dependent receptor
LPH50_RS03610	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
LPH50_RS03615	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
LPH50_RS03640	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LPH50_RS03660	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LPH50_RS03660	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LPH50_RS03680	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LPH50_RS03685	COG0488	(ABC) transporter
LPH50_RS03695	COG3011	Protein conserved in bacteria
LPH50_RS03705	COG0564	pseudouridine synthase activity
LPH50_RS03710	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LPH50_RS03730	COG1028	Short-chain dehydrogenase reductase Sdr
LPH50_RS03735	COG2969	positive regulation of protein catabolic process
LPH50_RS03740	COG0625	glutathione transferase activity
LPH50_RS03760	COG0741	lytic transglycosylase activity
LPH50_RS03770	COG1702	phosphate starvation-inducible protein PhoH
LPH50_RS03785	COG4535	Mg2 and Co2 transporter CorC
LPH50_RS03820	COG3210	domain, Protein
LPH50_RS03825	COG2831	hemolysin activation secretion protein
LPH50_RS03850	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
LPH50_RS03870	COG3115	cell septum assembly
LPH50_RS03885	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
LPH50_RS03895	COG0316	Belongs to the HesB IscA family
LPH50_RS03920	COG0167	dihydroorotate dehydrogenase activity
LPH50_RS03925	COG0812	UDP-N-acetylmuramate dehydrogenase activity
LPH50_RS03930	COG0697	spore germination
LPH50_RS03935	COG0671	phosphoesterase, PA-phosphatase related
LPH50_RS03940	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
LPH50_RS03950	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
LPH50_RS03955	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
LPH50_RS03975	COG1132	(ABC) transporter
LPH50_RS03990	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
LPH50_RS03995	COG1538	Outer membrane efflux protein
LPH50_RS04000	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LPH50_RS04010	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
LPH50_RS04025	COG4783	chaperone-mediated protein folding
LPH50_RS04035	COG0473	3-isopropylmalate dehydrogenase activity
LPH50_RS04045	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LPH50_RS04055	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
LPH50_RS04065	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
LPH50_RS04065	COG0316	Belongs to the HesB IscA family
LPH50_RS04070	COG2154	pterin-4-alpha-carbinolamine dehydratase
LPH50_RS04085	COG0564	pseudouridine synthase activity
LPH50_RS04090	COG1530	ribonuclease E activity
LPH50_RS04110	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
LPH50_RS04125	COG0488	(ABC) transporter
LPH50_RS04135	COG1278	Cold shock
LPH50_RS04150	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LPH50_RS04160	COG0049	tRNA binding
LPH50_RS04175	COG0085	RNA polymerase activity
LPH50_RS04180	COG0222	ribosome binding
LPH50_RS04195	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
LPH50_RS04200	COG0250	Participates in transcription elongation, termination and antitermination
LPH50_RS04205	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LPH50_RS04215	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LPH50_RS04235	COG0012	GTP binding
LPH50_RS04240	COG0193	aminoacyl-tRNA hydrolase activity
LPH50_RS04245	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
LPH50_RS04250	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LPH50_RS04260	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
LPH50_RS04265	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
LPH50_RS04275	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
LPH50_RS04350	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LPH50_RS04355	COG0765	amino acid transport
LPH50_RS04360	COG1126	abc transporter atp-binding protein
LPH50_RS04365	COG0765	amino acid transport
LPH50_RS04370	COG1074	ATP-dependent DNA helicase activity
LPH50_RS04380	COG2095	MarC family integral membrane protein
LPH50_RS04385	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
LPH50_RS04415	COG2132	Multicopper oxidase
LPH50_RS04425	COG0210	DNA helicase
LPH50_RS04435	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
LPH50_RS04440	COG0616	signal peptide processing
LPH50_RS04460	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
LPH50_RS04465	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LPH50_RS04470	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
LPH50_RS04480	COG2177	Part of the ABC transporter FtsEX involved in
LPH50_RS04485	COG2884	Cell division ATP-binding protein ftsE
LPH50_RS04490	COG0513	Belongs to the DEAD box helicase family
LPH50_RS04495	COG3118	belongs to the thioredoxin family
LPH50_RS04500	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
LPH50_RS04525	COG0793	Belongs to the peptidase S41A family
LPH50_RS04530	COG4942	peptidase
LPH50_RS04540	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
LPH50_RS04560	COG0493	'glutamate synthase
LPH50_RS04565	COG0067	glutamate synthase
LPH50_RS04565	COG0069	glutamate synthase activity
LPH50_RS04565	COG0070	glutamate synthase
LPH50_RS04665	COG3210	domain, Protein
LPH50_RS04805	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
LPH50_RS04815	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
LPH50_RS04820	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
LPH50_RS04935	COG1028	Short-chain dehydrogenase reductase Sdr
LPH50_RS04955	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LPH50_RS04965	COG1199	ATP-dependent helicase activity
LPH50_RS04975	COG0288	reversible hydration of carbon dioxide
LPH50_RS04980	COG0438	transferase activity, transferring glycosyl groups
LPH50_RS04995	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LPH50_RS05000	COG2011	ABC-type metal ion transport system permease component
LPH50_RS05005	COG1464	Belongs to the NlpA lipoprotein family
LPH50_RS05020	COG0508	dehydrogenase complex catalyzes the overall conversion of
LPH50_RS05025	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LPH50_RS05040	COG0626	cystathionine gamma-synthase activity
LPH50_RS05045	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LPH50_RS05050	COG0739	heme binding
LPH50_RS05060	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
LPH50_RS05065	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
LPH50_RS05090	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LPH50_RS05115	COG3525	Glycosyl hydrolase, family 20, catalytic domain
LPH50_RS05125	COG1472	Belongs to the glycosyl hydrolase 3 family
LPH50_RS05140	COG3537	Alpha-1,2-mannosidase
LPH50_RS05160	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
LPH50_RS05170	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LPH50_RS05175	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LPH50_RS05180	COG2207	Transcriptional regulator
LPH50_RS05185	COG2249	NAD(P)H dehydrogenase (quinone) activity
LPH50_RS05215	COG3588	fructose-bisphosphate aldolase
LPH50_RS05230	COG0469	pyruvate kinase activity
LPH50_RS05250	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LPH50_RS05255	COG0735	belongs to the Fur family
LPH50_RS05270	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
LPH50_RS05270	COG5297	Belongs to the glycosyl hydrolase family 6
LPH50_RS05280	COG0612	Peptidase, M16
LPH50_RS05300	COG0653	protein targeting
LPH50_RS05305	COG0739	heme binding
LPH50_RS05315	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
LPH50_RS05330	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
LPH50_RS05335	COG1181	Belongs to the D-alanine--D-alanine ligase family
LPH50_RS05340	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LPH50_RS05355	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LPH50_RS05360	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LPH50_RS05375	COG3116	cell division
LPH50_RS05380	COG0275	rRNA processing
LPH50_RS05390	COG0471	metal ion transport
LPH50_RS05390	COG3273	potassium ion transport
LPH50_RS05395	COG0220	tRNA (guanine-N7-)-methyltransferase activity
LPH50_RS05440	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LPH50_RS05465	COG0717	Belongs to the dCTP deaminase family
LPH50_RS05480	COG0860	N-Acetylmuramoyl-L-alanine amidase
LPH50_RS05485	COG0802	atpase or kinase
LPH50_RS05490	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
LPH50_RS05490	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
LPH50_RS05495	COG1570	exodeoxyribonuclease VII activity
LPH50_RS05540	COG0776	regulation of translation
LPH50_RS05545	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LPH50_RS05545	COG0072	phenylalanine-tRNA ligase activity
LPH50_RS05550	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
LPH50_RS05555	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
LPH50_RS05565	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
LPH50_RS05585	COG0745	RESPONSE REGULATOR receiver
LPH50_RS05600	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
LPH50_RS05650	COG0045	succinate-CoA ligase (ADP-forming) activity
LPH50_RS05655	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
LPH50_RS05660	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
LPH50_RS05675	COG0594	ribonuclease P activity
LPH50_RS05685	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LPH50_RS05695	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
LPH50_RS05700	COG0187	DNA topoisomerase II activity
LPH50_RS05710	COG0501	Belongs to the peptidase M48B family
LPH50_RS05755	COG0408	coproporphyrinogen oxidase activity
LPH50_RS05780	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LPH50_RS05850	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
LPH50_RS05860	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
LPH50_RS05870	COG0511	ligase activity, forming carbon-carbon bonds
LPH50_RS05875	COG0439	Biotin carboxylase
LPH50_RS05880	COG0210	DNA helicase
LPH50_RS05920	COG1040	competence protein
LPH50_RS05925	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
LPH50_RS05930	COG1752	Esterase of the alpha-beta hydrolase superfamily
LPH50_RS05935	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
LPH50_RS05950	COG2027	D-alanyl-D-alanine carboxypeptidase
LPH50_RS05985	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LPH50_RS05995	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
LPH50_RS06020	COG3121	Chaperone
LPH50_RS06025	COG3539	Fimbrial protein
LPH50_RS06030	COG1546	Belongs to the CinA family
LPH50_RS06035	COG0477	Major facilitator Superfamily
LPH50_RS06040	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LPH50_RS06045	COG1923	regulation of RNA biosynthetic process
LPH50_RS06055	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
LPH50_RS06060	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LPH50_RS06070	COG1534	Rna-binding protein
LPH50_RS06085	COG0129	dihydroxy-acid dehydratase activity
LPH50_RS06115	COG1560	Kdo2-lipid A biosynthetic process
LPH50_RS06120	COG1519	Transferase
LPH50_RS06135	COG0228	four-way junction DNA binding
LPH50_RS06140	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
LPH50_RS06145	COG0336	Belongs to the RNA methyltransferase TrmD family
LPH50_RS06150	COG0335	large ribosomal subunit rRNA binding
LPH50_RS06170	COG1393	Belongs to the ArsC family
LPH50_RS06180	COG0367	asparagine synthase
LPH50_RS06190	COG2070	2-Nitropropane dioxygenase
LPH50_RS06210	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LPH50_RS06225	COG0339	signal peptide processing
LPH50_RS06250	COG0525	valine-tRNA ligase activity
LPH50_RS06290	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LPH50_RS06315	COG4221	oxidoreductase activity
LPH50_RS06325	COG0018	arginyl-trna synthetase
LPH50_RS06330	COG2003	Belongs to the UPF0758 family
LPH50_RS06335	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
LPH50_RS06410	COG2223	nitrite transmembrane transporter activity
LPH50_RS06415	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
LPH50_RS06420	COG0739	heme binding
LPH50_RS06425	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
LPH50_RS06455	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LPH50_RS06480	COG1028	Short-chain dehydrogenase reductase Sdr
LPH50_RS06490	COG1272	protein, Hemolysin III
LPH50_RS06495	COG0463	Glycosyl transferase, family 2
LPH50_RS06505	COG0084	hydrolase, TatD family'
LPH50_RS06520	COG0509	glycine decarboxylation via glycine cleavage system
LPH50_RS06525	COG0404	The glycine cleavage system catalyzes the degradation of glycine
LPH50_RS06535	COG0330	HflC and HflK could
LPH50_RS06540	COG3956	TIGRFAM MazG family protein
LPH50_RS06545	COG1218	3'(2'),5'-bisphosphate nucleotidase
LPH50_RS06550	COG0494	nUDIX hydrolase
LPH50_RS06560	COG1385	rRNA (uridine-N3-)-methyltransferase activity
LPH50_RS06570	COG0513	Belongs to the DEAD box helicase family
LPH50_RS06575	COG0720	synthase
LPH50_RS06600	COG1981	membrane
LPH50_RS06610	COG0587	DNA-directed DNA polymerase activity
LPH50_RS06620	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
LPH50_RS06625	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LPH50_RS06640	COG0512	Glutamine amidotransferase of anthranilate synthase
LPH50_RS06645	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LPH50_RS06685	COG0006	proline dipeptidase activity
LPH50_RS06705	COG1862	Preprotein translocase
LPH50_RS06710	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LPH50_RS06715	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LPH50_RS06725	COG0617	tRNA 3'-terminal CCA addition
LPH50_RS06740	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
LPH50_RS06745	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
LPH50_RS06750	COG0166	Belongs to the GPI family
LPH50_RS06760	COG0779	Required for maturation of 30S ribosomal subunits
LPH50_RS06765	COG0195	Participates in both transcription termination and antitermination
LPH50_RS06770	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
LPH50_RS06775	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
LPH50_RS06780	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
LPH50_RS06790	COG1185	polyribonucleotide nucleotidyltransferase activity
LPH50_RS06795	COG1733	regulation of RNA biosynthetic process
LPH50_RS06800	COG0702	epimerase
LPH50_RS06815	COG0475	glutathione-regulated potassium exporter activity
LPH50_RS06845	COG2086	electron transfer activity
LPH50_RS06875	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LPH50_RS06935	COG0477	Major facilitator Superfamily
LPH50_RS06960	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LPH50_RS06965	COG0671	phosphoesterase, PA-phosphatase related
LPH50_RS06990	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LPH50_RS07000	COG0628	permease
LPH50_RS07020	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LPH50_RS07025	COG1090	epimerase
LPH50_RS07030	COG0318	PFAM AMP-dependent synthetase and ligase
LPH50_RS07050	COG1049	propionate catabolic process, 2-methylcitrate cycle
LPH50_RS07065	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
LPH50_RS07070	COG0732	type I restriction modification DNA specificity domain
LPH50_RS07085	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
LPH50_RS07125	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LPH50_RS07135	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LPH50_RS07145	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
LPH50_RS07150	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
LPH50_RS07155	COG1034	ATP synthesis coupled electron transport
LPH50_RS07190	COG1007	ATP synthesis coupled electron transport
LPH50_RS07195	COG1028	Short-chain dehydrogenase reductase Sdr
LPH50_RS07200	COG2851	Citrate transporter
LPH50_RS07215	COG0642	Histidine kinase
LPH50_RS07230	COG0784	Response regulator, receiver
LPH50_RS07230	COG2198	Histidine kinase
LPH50_RS07230	COG2205	protein histidine kinase activity
LPH50_RS07240	COG1301	dicarboxylic acid transport
LPH50_RS07245	COG0280	phosphate acetyltransferase
LPH50_RS07245	COG0281	malic enzyme
LPH50_RS07255	COG0742	ribosomal rna small subunit methyltransferase
LPH50_RS07270	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
LPH50_RS07290	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LPH50_RS07295	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
LPH50_RS07325	COG2166	iron-sulfur cluster assembly
LPH50_RS07330	COG0215	cysteine-tRNA ligase activity
LPH50_RS07350	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LPH50_RS07370	COG0165	Argininosuccinate lyase
LPH50_RS07385	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
LPH50_RS07420	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
LPH50_RS07480	COG5314	conjugation
LPH50_RS07505	COG1233	COG1233 Phytoene dehydrogenase and related
LPH50_RS07515	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LPH50_RS07530	COG1028	Short-chain dehydrogenase reductase Sdr
LPH50_RS07550	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
LPH50_RS07630	COG1914	H( )-stimulated, divalent metal cation uptake system
LPH50_RS07645	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
LPH50_RS07655	COG1946	Acyl-CoA thioesterase
LPH50_RS07730	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LPH50_RS07745	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LPH50_RS07765	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
LPH50_RS07770	COG0575	Belongs to the CDS family
LPH50_RS07805	COG2833	Protein of unknown function (DUF455)
LPH50_RS07810	COG0528	UMP kinase activity
LPH50_RS07880	COG0800	Aldolase
LPH50_RS07890	COG0363	glucosamine-6-phosphate deaminase activity
LPH50_RS07895	COG0837	glucose binding
LPH50_RS07900	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
LPH50_RS07905	COG3842	ATPase activity
LPH50_RS07925	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
LPH50_RS07940	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
LPH50_RS07950	COG4591	ABC-type transport system involved in lipoprotein release permease component
LPH50_RS07955	COG1136	(ABC) transporter
LPH50_RS07960	COG2333	competence protein COMEC
LPH50_RS07960	COG0658	competence protein
LPH50_RS07980	COG1663	tetraacyldisaccharide 4'-kinase activity
LPH50_RS07985	COG0489	protein tyrosine kinase activity
LPH50_RS07990	COG2062	phosphohistidine phosphatase, SixA
LPH50_RS08000	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LPH50_RS08045	COG0009	L-threonylcarbamoyladenylate synthase
LPH50_RS08050	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LPH50_RS08050	COG1754	DNA topoisomerase type I activity
LPH50_RS08060	COG2922	Belongs to the Smg family
LPH50_RS08065	COG0758	DNA mediated transformation
LPH50_RS08080	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LPH50_RS08090	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
LPH50_RS08155	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LPH50_RS08230	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
LPH50_RS08235	COG0505	Belongs to the CarA family
LPH50_RS08240	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LPH50_RS08245	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LPH50_RS08255	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
LPH50_RS08265	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
LPH50_RS08280	COG1024	Enoyl-CoA hydratase
LPH50_RS08285	COG0527	aspartate kinase activity
LPH50_RS08295	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
LPH50_RS08315	COG0494	nUDIX hydrolase
LPH50_RS08325	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
LPH50_RS08350	COG0312	modulator of DNA gyrase
LPH50_RS08355	COG3028	Belongs to the UPF0307 family
LPH50_RS08360	COG0312	modulator of DNA gyrase
LPH50_RS08395	COG0583	DNA-binding transcription factor activity
LPH50_RS08410	COG1064	alcohol dehydrogenase
LPH50_RS08425	COG0667	Aldo Keto reductase
LPH50_RS08455	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
LPH50_RS08485	COG0356	it plays a direct role in the translocation of protons across the membrane
LPH50_RS08510	COG0089	rRNA binding
LPH50_RS08520	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
LPH50_RS08525	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
LPH50_RS08530	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
LPH50_RS08590	COG1841	ribosomal large subunit assembly
LPH50_RS08595	COG0200	Binds to the 23S rRNA
LPH50_RS08600	COG0201	protein transport
LPH50_RS08605	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
LPH50_RS08610	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
LPH50_RS08630	COG2960	long-chain fatty acid transporting porin activity
LPH50_RS08635	COG0606	chelatase, subunit chli
LPH50_RS08640	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
LPH50_RS08655	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
LPH50_RS08670	COG0544	peptidyl-prolyl cis-trans isomerase activity
LPH50_RS08675	COG0740	serine-type endopeptidase activity
LPH50_RS08680	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
LPH50_RS08715	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LPH50_RS08720	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LPH50_RS08745	COG1187	pseudouridine synthase activity
LPH50_RS08750	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LPH50_RS08770	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LPH50_RS08805	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LPH50_RS08805	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LPH50_RS08825	COG3772	lysozyme
LPH50_RS08865	COG0625	glutathione transferase activity
LPH50_RS08875	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LPH50_RS08880	COG1217	gtp-binding protein TYPA
LPH50_RS08925	COG0842	Transport permease protein
LPH50_RS08930	COG1131	(ABC) transporter
LPH50_RS08950	COG1643	Atp-dependent helicase
LPH50_RS08960	COG1956	GAF domain-containing protein
LPH50_RS08965	COG0729	surface antigen
LPH50_RS08970	COG2911	Protein conserved in bacteria
LPH50_RS09020	COG1937	Protein conserved in bacteria
LPH50_RS09055	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
LPH50_RS09060	COG0668	transmembrane transport
LPH50_RS09090	COG2733	membrane
LPH50_RS09105	COG2921	Belongs to the UPF0250 family
LPH50_RS09110	COG0321	lipoyl(octanoyl) transferase activity
LPH50_RS09115	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
LPH50_RS09145	COG1253	flavin adenine dinucleotide binding
LPH50_RS09170	COG0504	CTP synthase activity
LPH50_RS09175	COG2877	3-deoxy-8-phosphooctulonate synthase activity
LPH50_RS09180	COG0148	phosphopyruvate hydratase activity
LPH50_RS09195	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
LPH50_RS09200	COG2840	Smr protein MutS2
LPH50_RS09210	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
LPH50_RS09210	COG0644	oxidoreductase
LPH50_RS09225	COG3218	ABC-type transport auxiliary lipoprotein component
LPH50_RS09225	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
LPH50_RS09230	COG1127	ABC transporter
LPH50_RS09235	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LPH50_RS09300	COG1077	Cell shape determining protein MreB Mrl
LPH50_RS09310	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
LPH50_RS09315	COG0768	penicillin binding
LPH50_RS09320	COG0772	Belongs to the SEDS family
LPH50_RS09330	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LPH50_RS09350	COG2894	cell division
LPH50_RS09355	COG0850	regulation of cytokinetic process
LPH50_RS09375	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
LPH50_RS09385	COG3038	cytochrome b561
LPH50_RS09390	COG2353	YceI-like domain
LPH50_RS09395	COG5002	protein histidine kinase activity
LPH50_RS09395	COG0784	Response regulator, receiver
LPH50_RS09405	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
LPH50_RS09430	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LPH50_RS09460	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
LPH50_RS09465	COG4208	sulfate ABC transporter
LPH50_RS09590	COG5532	Uncharacterized conserved protein (DUF2303)
LPH50_RS09615	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LPH50_RS09640	COG1566	PFAM secretion protein HlyD family protein
LPH50_RS09645	COG2814	Major facilitator Superfamily
LPH50_RS09650	COG2267	carboxylic ester hydrolase activity
LPH50_RS09670	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LPH50_RS09675	COG0617	tRNA 3'-terminal CCA addition
LPH50_RS09680	COG0741	lytic transglycosylase activity
LPH50_RS09755	COG1028	Short-chain dehydrogenase reductase Sdr
LPH50_RS09770	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
LPH50_RS09775	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
LPH50_RS09795	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
LPH50_RS09800	COG0483	inositol monophosphate 1-phosphatase activity
LPH50_RS09810	COG1509	lysine 2,3-aminomutase activity
LPH50_RS09820	COG0402	S-adenosylhomocysteine deaminase activity
LPH50_RS09825	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LPH50_RS09830	COG0546	phosphoglycolate phosphatase activity
LPH50_RS09840	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LPH50_RS09875	COG0436	Aminotransferase
LPH50_RS09890	COG1187	pseudouridine synthase activity
LPH50_RS09895	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
LPH50_RS09900	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
LPH50_RS09935	COG0395	ABC-type sugar transport system, permease component
LPH50_RS09950	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LPH50_RS09955	COG2957	Belongs to the agmatine deiminase family
LPH50_RS09980	COG0776	regulation of translation
LPH50_RS09990	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
LPH50_RS10005	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LPH50_RS10010	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
LPH50_RS10085	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LPH50_RS10095	COG0211	Belongs to the bacterial ribosomal protein bL27 family
LPH50_RS10100	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
LPH50_RS10105	COG0268	Binds directly to 16S ribosomal RNA
LPH50_RS10110	COG0728	peptidoglycan biosynthetic process
LPH50_RS10115	COG0196	riboflavin kinase activity
LPH50_RS10120	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
LPH50_RS10145	COG1396	sequence-specific DNA binding
LPH50_RS10200	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LPH50_RS10200	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
LPH50_RS10275	COG0436	Aminotransferase
LPH50_RS10285	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
LPH50_RS10310	COG1902	pentaerythritol trinitrate reductase activity
LPH50_RS10320	COG1335	isochorismatase
LPH50_RS10330	COG1064	alcohol dehydrogenase
LPH50_RS10335	COG0604	alcohol dehydrogenase
LPH50_RS10360	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LPH50_RS10365	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LPH50_RS10395	COG0473	3-isopropylmalate dehydrogenase activity
LPH50_RS10425	COG0438	transferase activity, transferring glycosyl groups
LPH50_RS10435	COG2244	polysaccharide biosynthetic process
LPH50_RS10440	COG0438	transferase activity, transferring glycosyl groups
LPH50_RS10455	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LPH50_RS10460	COG2954	triphosphatase activity
LPH50_RS10465	COG1472	Belongs to the glycosyl hydrolase 3 family
LPH50_RS10470	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
LPH50_RS10480	COG1278	Cold shock
LPH50_RS10505	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LPH50_RS10515	COG0497	DNA recombination
LPH50_RS10530	COG0443	Heat shock 70 kDa protein
LPH50_RS10535	COG0484	heat shock protein binding
LPH50_RS10550	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
LPH50_RS10560	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
LPH50_RS10580	COG0745	RESPONSE REGULATOR receiver
LPH50_RS10585	COG2205	protein histidine kinase activity
LPH50_RS10595	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
LPH50_RS10600	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
LPH50_RS10620	COG2967	ApaG domain
LPH50_RS10630	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LPH50_RS10635	COG0704	Plays a role in the regulation of phosphate uptake
LPH50_RS10645	COG0581	inorganic phosphate transmembrane transporter activity
LPH50_RS10650	COG0573	inorganic phosphate transmembrane transporter activity
LPH50_RS10655	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
LPH50_RS10660	COG4651	solute:proton antiporter activity
LPH50_RS10660	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LPH50_RS10670	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
LPH50_RS10680	COG0488	(ABC) transporter
LPH50_RS10705	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LPH50_RS10715	COG0489	protein tyrosine kinase activity
LPH50_RS10740	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LPH50_RS10795	COG1469	GTP cyclohydrolase I activity
LPH50_RS10805	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LPH50_RS10810	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LPH50_RS10815	COG2902	Dehydrogenase
LPH50_RS10820	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
LPH50_RS10850	COG2925	Exonuclease
LPH50_RS10870	COG0025	NhaP-type Na H and K H
LPH50_RS10890	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LPH50_RS10910	COG3079	Belongs to the UPF0149 family
LPH50_RS10915	COG0006	proline dipeptidase activity
LPH50_RS10955	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LPH50_RS11015	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LPH50_RS11040	COG3772	lysozyme
LPH50_RS11060	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LPH50_RS11060	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LPH50_RS11100	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LPH50_RS11110	COG0328	RNA-DNA hybrid ribonuclease activity
LPH50_RS11115	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LPH50_RS11135	COG0859	PFAM glycosyl transferase family 9
LPH50_RS11145	COG2943	transferase activity, transferring hexosyl groups
LPH50_RS11150	COG0400	carboxylic ester hydrolase activity
LPH50_RS11155	COG3275	phosphorelay sensor kinase activity
LPH50_RS11200	COG0463	Glycosyl transferase, family 2
LPH50_RS11210	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LPH50_RS11225	COG0392	lysyltransferase activity
LPH50_RS11225	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
LPH50_RS11230	COG0251	oxidation-reduction process
LPH50_RS11245	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
LPH50_RS11250	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LPH50_RS11255	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
LPH50_RS11260	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
LPH50_RS11280	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
LPH50_RS11330	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LPH50_RS11440	COG0582	viral genome integration into host DNA
LPH50_RS11455	COG3772	lysozyme
LPH50_RS11510	COG0640	Transcriptional regulator
LPH50_RS11525	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LPH50_RS11550	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LPH50_RS11585	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
LPH50_RS11590	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
LPH50_RS11600	COG0537	adenosine 5'-monophosphoramidase activity
LPH50_RS11620	COG0714	Associated with various cellular activities
LPH50_RS11630	COG1399	metal-binding, possibly nucleic acid-binding protein
LPH50_RS11635	COG0333	Belongs to the bacterial ribosomal protein bL32 family
LPH50_RS11640	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LPH50_RS11655	COG5297	Belongs to the glycosyl hydrolase family 6
LPH50_RS11660	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LPH50_RS11680	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
LPH50_RS11690	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LPH50_RS11695	COG1764	response to oxidative stress
LPH50_RS11700	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
LPH50_RS11705	COG2945	thiolester hydrolase activity
LPH50_RS11765	COG2353	YceI-like domain
LPH50_RS11770	COG1968	undecaprenyl-diphosphatase activity
LPH50_RS11775	COG0174	glutamine synthetase
LPH50_RS11780	COG0347	Belongs to the P(II) protein family
LPH50_RS11785	COG0004	ammonium transporteR
LPH50_RS11815	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
LPH50_RS11820	COG0084	hydrolase, TatD family'
LPH50_RS11905	COG1487	ribonuclease activity