locus-tag	class	description
LPH58_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LPH58_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
LPH58_RS00020	COG0187	DNA topoisomerase II activity
LPH58_RS00030	COG0501	Belongs to the peptidase M48B family
LPH58_RS00075	COG0408	coproporphyrinogen oxidase activity
LPH58_RS00100	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LPH58_RS00170	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
LPH58_RS00180	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
LPH58_RS00190	COG0511	ligase activity, forming carbon-carbon bonds
LPH58_RS00195	COG0439	Biotin carboxylase
LPH58_RS00200	COG0210	DNA helicase
LPH58_RS00235	COG1040	competence protein
LPH58_RS00240	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
LPH58_RS00245	COG1752	Esterase of the alpha-beta hydrolase superfamily
LPH58_RS00250	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
LPH58_RS00270	COG2027	D-alanyl-D-alanine carboxypeptidase
LPH58_RS00305	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LPH58_RS00315	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
LPH58_RS00340	COG3121	Chaperone
LPH58_RS00345	COG3539	Fimbrial protein
LPH58_RS00350	COG1546	Belongs to the CinA family
LPH58_RS00355	COG0477	Major facilitator Superfamily
LPH58_RS00360	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LPH58_RS00365	COG1923	regulation of RNA biosynthetic process
LPH58_RS00375	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
LPH58_RS00380	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LPH58_RS00390	COG1534	Rna-binding protein
LPH58_RS00405	COG0129	dihydroxy-acid dehydratase activity
LPH58_RS00435	COG1560	Kdo2-lipid A biosynthetic process
LPH58_RS00440	COG1519	Transferase
LPH58_RS00460	COG0228	four-way junction DNA binding
LPH58_RS00465	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
LPH58_RS00470	COG0336	Belongs to the RNA methyltransferase TrmD family
LPH58_RS00475	COG0335	large ribosomal subunit rRNA binding
LPH58_RS00495	COG1393	Belongs to the ArsC family
LPH58_RS00505	COG0367	asparagine synthase
LPH58_RS00515	COG2070	2-Nitropropane dioxygenase
LPH58_RS00535	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LPH58_RS00550	COG0339	signal peptide processing
LPH58_RS00575	COG0525	valine-tRNA ligase activity
LPH58_RS00615	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LPH58_RS00640	COG4221	oxidoreductase activity
LPH58_RS00650	COG0018	arginyl-trna synthetase
LPH58_RS00655	COG2003	Belongs to the UPF0758 family
LPH58_RS00660	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
LPH58_RS00725	COG2223	nitrite transmembrane transporter activity
LPH58_RS00730	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
LPH58_RS00735	COG0739	heme binding
LPH58_RS00740	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
LPH58_RS00770	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LPH58_RS00795	COG1028	Short-chain dehydrogenase reductase Sdr
LPH58_RS00805	COG1272	protein, Hemolysin III
LPH58_RS00810	COG0463	Glycosyl transferase, family 2
LPH58_RS00815	COG0084	hydrolase, TatD family'
LPH58_RS00830	COG0509	glycine decarboxylation via glycine cleavage system
LPH58_RS00835	COG0404	The glycine cleavage system catalyzes the degradation of glycine
LPH58_RS00845	COG0330	HflC and HflK could
LPH58_RS00850	COG3956	TIGRFAM MazG family protein
LPH58_RS00855	COG1218	3'(2'),5'-bisphosphate nucleotidase
LPH58_RS00860	COG0494	nUDIX hydrolase
LPH58_RS00870	COG1385	rRNA (uridine-N3-)-methyltransferase activity
LPH58_RS00880	COG0513	Belongs to the DEAD box helicase family
LPH58_RS00885	COG0720	synthase
LPH58_RS00910	COG1981	membrane
LPH58_RS00920	COG0587	DNA-directed DNA polymerase activity
LPH58_RS00930	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
LPH58_RS00935	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LPH58_RS00950	COG0512	Glutamine amidotransferase of anthranilate synthase
LPH58_RS00955	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LPH58_RS00995	COG0006	proline dipeptidase activity
LPH58_RS01015	COG1862	Preprotein translocase
LPH58_RS01020	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LPH58_RS01025	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LPH58_RS01035	COG0617	tRNA 3'-terminal CCA addition
LPH58_RS01050	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
LPH58_RS01055	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
LPH58_RS01060	COG0166	Belongs to the GPI family
LPH58_RS01070	COG0779	Required for maturation of 30S ribosomal subunits
LPH58_RS01075	COG0195	Participates in both transcription termination and antitermination
LPH58_RS01080	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
LPH58_RS01085	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
LPH58_RS01090	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
LPH58_RS01100	COG1185	polyribonucleotide nucleotidyltransferase activity
LPH58_RS01105	COG1733	regulation of RNA biosynthetic process
LPH58_RS01110	COG0702	epimerase
LPH58_RS01125	COG0475	glutathione-regulated potassium exporter activity
LPH58_RS01155	COG2086	electron transfer activity
LPH58_RS01185	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LPH58_RS01240	COG0477	Major facilitator Superfamily
LPH58_RS01265	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LPH58_RS01270	COG0671	phosphoesterase, PA-phosphatase related
LPH58_RS01300	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LPH58_RS01310	COG0628	permease
LPH58_RS01330	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LPH58_RS01335	COG1090	epimerase
LPH58_RS01340	COG0318	PFAM AMP-dependent synthetase and ligase
LPH58_RS01360	COG1049	propionate catabolic process, 2-methylcitrate cycle
LPH58_RS01375	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
LPH58_RS01380	COG0732	type I restriction modification DNA specificity domain
LPH58_RS01395	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
LPH58_RS01430	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LPH58_RS01440	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LPH58_RS01450	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
LPH58_RS01455	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
LPH58_RS01460	COG1034	ATP synthesis coupled electron transport
LPH58_RS01495	COG1007	ATP synthesis coupled electron transport
LPH58_RS01500	COG1028	Short-chain dehydrogenase reductase Sdr
LPH58_RS01505	COG2851	Citrate transporter
LPH58_RS01520	COG0642	Histidine kinase
LPH58_RS01535	COG0784	Response regulator, receiver
LPH58_RS01535	COG2198	Histidine kinase
LPH58_RS01535	COG2205	protein histidine kinase activity
LPH58_RS01545	COG1301	dicarboxylic acid transport
LPH58_RS01550	COG0280	phosphate acetyltransferase
LPH58_RS01550	COG0281	malic enzyme
LPH58_RS01560	COG0742	ribosomal rna small subunit methyltransferase
LPH58_RS01575	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
LPH58_RS01595	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LPH58_RS01600	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
LPH58_RS01630	COG2166	iron-sulfur cluster assembly
LPH58_RS01635	COG0215	cysteine-tRNA ligase activity
LPH58_RS01655	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LPH58_RS01675	COG0165	Argininosuccinate lyase
LPH58_RS01690	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
LPH58_RS01725	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
LPH58_RS01785	COG5314	conjugation
LPH58_RS01810	COG1233	COG1233 Phytoene dehydrogenase and related
LPH58_RS01820	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LPH58_RS01835	COG1028	Short-chain dehydrogenase reductase Sdr
LPH58_RS01855	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
LPH58_RS01935	COG1914	H( )-stimulated, divalent metal cation uptake system
LPH58_RS01950	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
LPH58_RS01960	COG1946	Acyl-CoA thioesterase
LPH58_RS02045	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LPH58_RS02060	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LPH58_RS02080	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
LPH58_RS02085	COG0575	Belongs to the CDS family
LPH58_RS02125	COG2833	Protein of unknown function (DUF455)
LPH58_RS02130	COG0528	UMP kinase activity
LPH58_RS02205	COG0800	Aldolase
LPH58_RS02215	COG0363	glucosamine-6-phosphate deaminase activity
LPH58_RS02220	COG0837	glucose binding
LPH58_RS02225	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
LPH58_RS02230	COG3842	ATPase activity
LPH58_RS02250	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
LPH58_RS02265	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
LPH58_RS02275	COG4591	ABC-type transport system involved in lipoprotein release permease component
LPH58_RS02280	COG1136	(ABC) transporter
LPH58_RS02285	COG2333	competence protein COMEC
LPH58_RS02285	COG0658	competence protein
LPH58_RS02305	COG1663	tetraacyldisaccharide 4'-kinase activity
LPH58_RS02310	COG0489	protein tyrosine kinase activity
LPH58_RS02315	COG2062	phosphohistidine phosphatase, SixA
LPH58_RS02325	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LPH58_RS02370	COG0009	L-threonylcarbamoyladenylate synthase
LPH58_RS02375	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LPH58_RS02375	COG1754	DNA topoisomerase type I activity
LPH58_RS02385	COG2922	Belongs to the Smg family
LPH58_RS02390	COG0758	DNA mediated transformation
LPH58_RS02405	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LPH58_RS02415	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
LPH58_RS02480	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LPH58_RS02555	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
LPH58_RS02560	COG0505	Belongs to the CarA family
LPH58_RS02565	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LPH58_RS02570	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LPH58_RS02580	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
LPH58_RS02590	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
LPH58_RS02605	COG1024	Enoyl-CoA hydratase
LPH58_RS02610	COG0527	aspartate kinase activity
LPH58_RS02620	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
LPH58_RS02640	COG0494	nUDIX hydrolase
LPH58_RS02650	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
LPH58_RS02675	COG0312	modulator of DNA gyrase
LPH58_RS02680	COG3028	Belongs to the UPF0307 family
LPH58_RS02685	COG0312	modulator of DNA gyrase
LPH58_RS02715	COG0583	DNA-binding transcription factor activity
LPH58_RS02730	COG1064	alcohol dehydrogenase
LPH58_RS02745	COG0667	Aldo Keto reductase
LPH58_RS02775	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
LPH58_RS02805	COG0356	it plays a direct role in the translocation of protons across the membrane
LPH58_RS02830	COG0089	rRNA binding
LPH58_RS02840	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
LPH58_RS02845	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
LPH58_RS02850	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
LPH58_RS02910	COG1841	ribosomal large subunit assembly
LPH58_RS02915	COG0200	Binds to the 23S rRNA
LPH58_RS02920	COG0201	protein transport
LPH58_RS02925	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
LPH58_RS02930	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
LPH58_RS02950	COG2960	long-chain fatty acid transporting porin activity
LPH58_RS02955	COG0606	chelatase, subunit chli
LPH58_RS02960	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
LPH58_RS02975	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
LPH58_RS02990	COG0544	peptidyl-prolyl cis-trans isomerase activity
LPH58_RS02995	COG0740	serine-type endopeptidase activity
LPH58_RS03000	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
LPH58_RS03035	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LPH58_RS03040	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LPH58_RS03065	COG1187	pseudouridine synthase activity
LPH58_RS03070	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LPH58_RS03090	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LPH58_RS03125	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LPH58_RS03125	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LPH58_RS03145	COG3772	lysozyme
LPH58_RS03185	COG0625	glutathione transferase activity
LPH58_RS03195	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LPH58_RS03200	COG1217	gtp-binding protein TYPA
LPH58_RS03245	COG0842	Transport permease protein
LPH58_RS03250	COG1131	(ABC) transporter
LPH58_RS03270	COG1643	Atp-dependent helicase
LPH58_RS03280	COG1956	GAF domain-containing protein
LPH58_RS03285	COG0729	surface antigen
LPH58_RS03290	COG2911	Protein conserved in bacteria
LPH58_RS03340	COG1937	Protein conserved in bacteria
LPH58_RS03375	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
LPH58_RS03380	COG0668	transmembrane transport
LPH58_RS03410	COG2733	membrane
LPH58_RS03425	COG2921	Belongs to the UPF0250 family
LPH58_RS03430	COG0321	lipoyl(octanoyl) transferase activity
LPH58_RS03435	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
LPH58_RS03465	COG1253	flavin adenine dinucleotide binding
LPH58_RS03490	COG0504	CTP synthase activity
LPH58_RS03495	COG2877	3-deoxy-8-phosphooctulonate synthase activity
LPH58_RS03500	COG0148	phosphopyruvate hydratase activity
LPH58_RS03515	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
LPH58_RS03520	COG2840	Smr protein MutS2
LPH58_RS03530	COG0644	oxidoreductase
LPH58_RS03530	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
LPH58_RS03545	COG3218	ABC-type transport auxiliary lipoprotein component
LPH58_RS03545	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
LPH58_RS03550	COG1127	ABC transporter
LPH58_RS03555	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LPH58_RS03620	COG1077	Cell shape determining protein MreB Mrl
LPH58_RS03630	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
LPH58_RS03635	COG0768	penicillin binding
LPH58_RS03640	COG0772	Belongs to the SEDS family
LPH58_RS03650	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LPH58_RS03670	COG2894	cell division
LPH58_RS03675	COG0850	regulation of cytokinetic process
LPH58_RS03695	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
LPH58_RS03705	COG3038	cytochrome b561
LPH58_RS03710	COG2353	YceI-like domain
LPH58_RS03715	COG5002	protein histidine kinase activity
LPH58_RS03715	COG0784	Response regulator, receiver
LPH58_RS03725	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
LPH58_RS03750	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LPH58_RS03780	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
LPH58_RS03785	COG4208	sulfate ABC transporter
LPH58_RS03905	COG5532	Uncharacterized conserved protein (DUF2303)
LPH58_RS03930	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LPH58_RS03950	COG1566	PFAM secretion protein HlyD family protein
LPH58_RS03955	COG2814	Major facilitator Superfamily
LPH58_RS03960	COG2267	carboxylic ester hydrolase activity
LPH58_RS03980	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LPH58_RS03985	COG0617	tRNA 3'-terminal CCA addition
LPH58_RS03990	COG0741	lytic transglycosylase activity
LPH58_RS04065	COG1028	Short-chain dehydrogenase reductase Sdr
LPH58_RS04080	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
LPH58_RS04085	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
LPH58_RS04105	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
LPH58_RS04110	COG0483	inositol monophosphate 1-phosphatase activity
LPH58_RS04120	COG1509	lysine 2,3-aminomutase activity
LPH58_RS04130	COG0402	S-adenosylhomocysteine deaminase activity
LPH58_RS04135	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LPH58_RS04140	COG0546	phosphoglycolate phosphatase activity
LPH58_RS04150	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LPH58_RS04185	COG0436	Aminotransferase
LPH58_RS04200	COG1187	pseudouridine synthase activity
LPH58_RS04205	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
LPH58_RS04210	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
LPH58_RS04245	COG0395	ABC-type sugar transport system, permease component
LPH58_RS04260	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LPH58_RS04265	COG2957	Belongs to the agmatine deiminase family
LPH58_RS04290	COG0776	regulation of translation
LPH58_RS04300	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
LPH58_RS04315	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LPH58_RS04320	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
LPH58_RS04395	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LPH58_RS04405	COG0211	Belongs to the bacterial ribosomal protein bL27 family
LPH58_RS04410	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
LPH58_RS04415	COG0268	Binds directly to 16S ribosomal RNA
LPH58_RS04420	COG0728	peptidoglycan biosynthetic process
LPH58_RS04425	COG0196	riboflavin kinase activity
LPH58_RS04430	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
LPH58_RS04455	COG1396	sequence-specific DNA binding
LPH58_RS04510	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
LPH58_RS04510	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LPH58_RS04585	COG0436	Aminotransferase
LPH58_RS04595	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
LPH58_RS04615	COG1902	pentaerythritol trinitrate reductase activity
LPH58_RS04625	COG1335	isochorismatase
LPH58_RS04635	COG1064	alcohol dehydrogenase
LPH58_RS04640	COG0604	alcohol dehydrogenase
LPH58_RS04665	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LPH58_RS04670	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LPH58_RS04700	COG0473	3-isopropylmalate dehydrogenase activity
LPH58_RS04730	COG0438	transferase activity, transferring glycosyl groups
LPH58_RS04740	COG2244	polysaccharide biosynthetic process
LPH58_RS04745	COG0438	transferase activity, transferring glycosyl groups
LPH58_RS04760	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LPH58_RS04765	COG2954	triphosphatase activity
LPH58_RS04770	COG1472	Belongs to the glycosyl hydrolase 3 family
LPH58_RS04775	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
LPH58_RS04785	COG1278	Cold shock
LPH58_RS04810	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LPH58_RS04820	COG0497	DNA recombination
LPH58_RS04835	COG0443	Heat shock 70 kDa protein
LPH58_RS04840	COG0484	heat shock protein binding
LPH58_RS04855	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
LPH58_RS04865	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
LPH58_RS04885	COG0745	RESPONSE REGULATOR receiver
LPH58_RS04890	COG2205	protein histidine kinase activity
LPH58_RS04900	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
LPH58_RS04905	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
LPH58_RS04925	COG2967	ApaG domain
LPH58_RS04935	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LPH58_RS04940	COG0704	Plays a role in the regulation of phosphate uptake
LPH58_RS04950	COG0581	inorganic phosphate transmembrane transporter activity
LPH58_RS04955	COG0573	inorganic phosphate transmembrane transporter activity
LPH58_RS04960	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
LPH58_RS04965	COG4651	solute:proton antiporter activity
LPH58_RS04965	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LPH58_RS04975	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
LPH58_RS04985	COG0488	(ABC) transporter
LPH58_RS05010	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LPH58_RS05020	COG0489	protein tyrosine kinase activity
LPH58_RS05045	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LPH58_RS05100	COG1469	GTP cyclohydrolase I activity
LPH58_RS05110	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LPH58_RS05115	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LPH58_RS05120	COG2902	Dehydrogenase
LPH58_RS05125	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
LPH58_RS05155	COG2925	Exonuclease
LPH58_RS05175	COG0025	NhaP-type Na H and K H
LPH58_RS05195	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LPH58_RS05215	COG3079	Belongs to the UPF0149 family
LPH58_RS05220	COG0006	proline dipeptidase activity
LPH58_RS05260	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LPH58_RS05320	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LPH58_RS05345	COG3772	lysozyme
LPH58_RS05365	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LPH58_RS05365	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LPH58_RS05405	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LPH58_RS05415	COG0328	RNA-DNA hybrid ribonuclease activity
LPH58_RS05420	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LPH58_RS05440	COG0859	PFAM glycosyl transferase family 9
LPH58_RS05450	COG2943	transferase activity, transferring hexosyl groups
LPH58_RS05455	COG0400	carboxylic ester hydrolase activity
LPH58_RS05460	COG3275	phosphorelay sensor kinase activity
LPH58_RS05505	COG0463	Glycosyl transferase, family 2
LPH58_RS05515	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LPH58_RS05530	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
LPH58_RS05530	COG0392	lysyltransferase activity
LPH58_RS05535	COG0251	oxidation-reduction process
LPH58_RS05550	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
LPH58_RS05555	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LPH58_RS05560	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
LPH58_RS05565	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
LPH58_RS05585	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
LPH58_RS05635	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LPH58_RS05750	COG0582	viral genome integration into host DNA
LPH58_RS05765	COG3772	lysozyme
LPH58_RS05820	COG0640	Transcriptional regulator
LPH58_RS05835	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LPH58_RS05860	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LPH58_RS05895	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
LPH58_RS05900	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
LPH58_RS05910	COG0537	adenosine 5'-monophosphoramidase activity
LPH58_RS05930	COG0714	Associated with various cellular activities
LPH58_RS05940	COG1399	metal-binding, possibly nucleic acid-binding protein
LPH58_RS05945	COG0333	Belongs to the bacterial ribosomal protein bL32 family
LPH58_RS05950	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LPH58_RS05965	COG5297	Belongs to the glycosyl hydrolase family 6
LPH58_RS05970	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LPH58_RS05990	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
LPH58_RS06000	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LPH58_RS06005	COG1764	response to oxidative stress
LPH58_RS06010	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
LPH58_RS06015	COG2945	thiolester hydrolase activity
LPH58_RS06075	COG2353	YceI-like domain
LPH58_RS06080	COG1968	undecaprenyl-diphosphatase activity
LPH58_RS06085	COG0174	glutamine synthetase
LPH58_RS06090	COG0347	Belongs to the P(II) protein family
LPH58_RS06095	COG0004	ammonium transporteR
LPH58_RS06125	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
LPH58_RS06130	COG0084	hydrolase, TatD family'
LPH58_RS06215	COG1487	ribonuclease activity
LPH58_RS06225	COG0406	alpha-ribazole phosphatase activity
LPH58_RS06235	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
LPH58_RS06245	COG0386	Belongs to the glutathione peroxidase family
LPH58_RS06255	COG1515	deoxyribonuclease V activity
LPH58_RS06265	COG0602	queuosine metabolic process
LPH58_RS06275	COG2885	chlorophyll binding
LPH58_RS06290	COG0848	biopolymer transport protein
LPH58_RS06295	COG0811	peptide transport
LPH58_RS06300	COG0824	Thioesterase
LPH58_RS06310	COG3158	transport of potassium into the cell
LPH58_RS06325	COG0217	transcriptional regulatory protein
LPH58_RS06345	COG0552	protein localization to endoplasmic reticulum
LPH58_RS06370	COG3041	Addiction module toxin RelE StbE family
LPH58_RS06375	COG3077	Addiction module antitoxin, RelB DinJ family
LPH58_RS06450	COG2337	Toxic component of a toxin-antitoxin (TA) module
LPH58_RS06510	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
LPH58_RS06550	COG2091	lysine biosynthetic process via aminoadipic acid
LPH58_RS06560	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
LPH58_RS06565	COG1301	dicarboxylic acid transport
LPH58_RS06590	COG0339	signal peptide processing
LPH58_RS06600	COG0285	dihydrofolate synthase activity
LPH58_RS06625	COG2201	protein-glutamate methylesterase activity
LPH58_RS06630	COG0784	Response regulator, receiver
LPH58_RS06630	COG0643	Histidine kinase
LPH58_RS06630	COG2198	Histidine kinase
LPH58_RS06635	COG0840	transmembrane signaling receptor activity
LPH58_RS06665	COG0751	glycine-tRNA ligase activity
LPH58_RS06675	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
LPH58_RS06675	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LPH58_RS06700	COG0727	PFAM Uncharacterised protein family (UPF0153)
LPH58_RS06710	COG0596	Alpha beta hydrolase
LPH58_RS06720	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LPH58_RS06730	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
LPH58_RS06740	COG0138	bifunctional purine biosynthesis protein purh
LPH58_RS06745	COG0151	Belongs to the GarS family
LPH58_RS06765	COG1289	transmembrane transporter activity
LPH58_RS06775	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
LPH58_RS06785	COG0302	gtp cyclohydrolase
LPH58_RS06790	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
LPH58_RS06800	COG0557	exoribonuclease II activity
LPH58_RS06810	COG3772	lysozyme
LPH58_RS06905	COG1881	PFAM PEBP family protein
LPH58_RS06910	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
LPH58_RS06915	COG3118	belongs to the thioredoxin family
LPH58_RS06925	COG0495	leucyl-tRNA aminoacylation
LPH58_RS06955	COG2951	lytic endotransglycosylase activity
LPH58_RS07100	COG3210	domain, Protein
LPH58_RS07200	COG3210	domain, Protein
LPH58_RS07215	COG1280	lysine exporter protein (LysE YggA)
LPH58_RS07240	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LPH58_RS07245	COG0277	FAD linked oxidase domain protein
LPH58_RS07250	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LPH58_RS07255	COG0531	amino acid
LPH58_RS07260	COG0531	amino acid
LPH58_RS07265	COG0235	Class ii aldolase
LPH58_RS07270	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
LPH58_RS07275	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
LPH58_RS07320	COG0131	Imidazoleglycerol-phosphate dehydratase
LPH58_RS07320	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
LPH58_RS07330	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
LPH58_RS07335	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
LPH58_RS07355	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
LPH58_RS07360	COG0083	homoserine kinase activity
LPH58_RS07365	COG0527	aspartate kinase activity
LPH58_RS07365	COG0460	homoserine dehydrogenase
LPH58_RS07375	COG0540	Belongs to the ATCase OTCase family
LPH58_RS07390	COG1686	Belongs to the peptidase S11 family
LPH58_RS07395	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
LPH58_RS07410	COG4953	penicillin-binding protein 1C
LPH58_RS07445	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LPH58_RS07470	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
LPH58_RS07475	COG1381	Involved in DNA repair and RecF pathway recombination
LPH58_RS07490	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LPH58_RS07500	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LPH58_RS07510	COG1028	Short-chain dehydrogenase reductase Sdr
LPH58_RS07525	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LPH58_RS07530	COG0823	Involved in the tonB-independent uptake of proteins
LPH58_RS07530	COG1506	peptidase
LPH58_RS07535	COG1297	OPT oligopeptide transporter protein
LPH58_RS07570	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
LPH58_RS07580	COG0318	PFAM AMP-dependent synthetase and ligase
LPH58_RS07590	COG0463	Glycosyl transferase, family 2
LPH58_RS07600	COG1475	DNA binding
LPH58_RS07605	COG1192	Involved in chromosome partitioning
LPH58_RS07620	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
LPH58_RS07635	COG0077	Prephenate dehydratase
LPH58_RS07635	COG1605	Chorismate mutase
LPH58_RS07650	COG1668	transmembrane transport
LPH58_RS07655	COG4555	ABC transporter
LPH58_RS07685	COG1309	transcriptional regulator
LPH58_RS07690	COG2226	methyltransferase
LPH58_RS07700	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LPH58_RS07715	COG2900	Belongs to the SlyX family
LPH58_RS07730	COG0386	Belongs to the glutathione peroxidase family
LPH58_RS07740	COG1131	(ABC) transporter
LPH58_RS07765	COG2850	peptidyl-arginine hydroxylation
LPH58_RS07770	COG0567	Dehydrogenase, E1 component
LPH58_RS07790	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
LPH58_RS07815	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
LPH58_RS07845	COG0583	DNA-binding transcription factor activity
LPH58_RS07850	COG3634	alkyl hydroperoxide reductase activity
LPH58_RS07860	COG5295	Hep Hag repeat protein
LPH58_RS07865	COG1450	Type ii and iii secretion system protein
LPH58_RS07880	COG3166	PFAM Fimbrial assembly family protein
LPH58_RS07885	COG3156	type II secretion system protein K
LPH58_RS07895	COG3156	type II secretion system protein K
LPH58_RS07900	COG4795	General secretion pathway protein
LPH58_RS07905	COG2165	general secretion pathway protein
LPH58_RS07910	COG4970	Tfp pilus assembly protein FimT
LPH58_RS07915	COG2165	general secretion pathway protein
LPH58_RS07920	COG1459	type II secretion system
LPH58_RS07925	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LPH58_RS07970	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LPH58_RS07985	COG1561	YicC-like family, N-terminal region
LPH58_RS07990	COG0194	GDP metabolic process
LPH58_RS07995	COG1758	RNA polymerase activity
LPH58_RS08000	COG2895	sulfate adenylyltransferase (ATP) activity
LPH58_RS08000	COG0529	Catalyzes the synthesis of activated sulfate
LPH58_RS08005	COG0175	sulfate reduction
LPH58_RS08020	COG0175	sulfate reduction
LPH58_RS08075	COG0308	aminopeptidase N
LPH58_RS08080	COG2226	methyltransferase
LPH58_RS08135	COG1959	2 iron, 2 sulfur cluster binding
LPH58_RS08140	COG0719	Fe-S assembly protein
LPH58_RS08145	COG0396	ATPase activity
LPH58_RS08150	COG0719	Fe-S assembly protein
LPH58_RS08155	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LPH58_RS08160	COG2146	nitrite reductase [NAD(P)H] activity
LPH58_RS08165	COG0297	glycogen (starch) synthase activity
LPH58_RS08170	COG0726	polysaccharide deacetylase
LPH58_RS08175	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LPH58_RS08180	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
LPH58_RS08200	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
LPH58_RS08205	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LPH58_RS08225	COG0837	glucose binding
LPH58_RS08250	COG4191	Histidine kinase
LPH58_RS08270	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LPH58_RS08275	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
LPH58_RS08290	COG1674	ftsk spoiiie
LPH58_RS08295	COG0492	ferredoxin-NADP+ reductase activity
LPH58_RS08305	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
LPH58_RS08310	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
LPH58_RS08315	COG0542	response to heat
LPH58_RS08335	COG2915	High frequency lysogenization protein hflD homolog
LPH58_RS08380	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LPH58_RS08390	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LPH58_RS08395	COG0047	phosphoribosylformylglycinamidine synthase activity
LPH58_RS08395	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LPH58_RS08405	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LPH58_RS08420	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
LPH58_RS08435	COG1137	ATPase activity
LPH58_RS08455	COG1660	Displays ATPase and GTPase activities
LPH58_RS08465	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LPH58_RS08470	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LPH58_RS08475	COG2239	Acts as a magnesium transporter
LPH58_RS08490	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LPH58_RS08515	COG1595	DNA-templated transcription, initiation
LPH58_RS08540	COG0142	geranyltranstransferase activity
LPH58_RS08550	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LPH58_RS08555	COG1845	cytochrome c oxidase, subunit III
LPH58_RS08560	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
LPH58_RS08565	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LPH58_RS08565	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LPH58_RS08575	COG1643	Atp-dependent helicase
LPH58_RS08580	COG0783	Belongs to the Dps family
LPH58_RS08585	COG0514	ATP-dependent DNA helicase (RecQ)
LPH58_RS08605	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LPH58_RS08650	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LPH58_RS08730	COG0142	geranyltranstransferase activity
LPH58_RS08735	COG1722	exodeoxyribonuclease VII activity
LPH58_RS08740	COG0037	tRNA processing
LPH58_RS08750	COG1301	dicarboxylic acid transport
LPH58_RS08755	COG0791	NLP P60 protein
LPH58_RS08760	COG0791	NLP P60 protein
LPH58_RS08770	COG2311	Membrane
LPH58_RS08795	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
LPH58_RS08810	COG0545	Peptidyl-prolyl cis-trans isomerase
LPH58_RS08815	COG0494	nUDIX hydrolase
LPH58_RS08825	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
LPH58_RS08840	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LPH58_RS08845	COG0351	phosphomethylpyrimidine kinase
LPH58_RS08845	COG0352	thiamine-phosphate diphosphorylase activity
LPH58_RS08870	COG1324	tolerance protein
LPH58_RS08905	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LPH58_RS08910	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LPH58_RS08915	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
LPH58_RS08930	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
LPH58_RS08950	COG4774	siderophore transport
LPH58_RS08975	COG1477	protein flavinylation
LPH58_RS08980	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
LPH58_RS08985	COG1555	photosystem II stabilization
LPH58_RS08995	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
LPH58_RS09005	COG0628	permease
LPH58_RS09015	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
LPH58_RS09020	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
LPH58_RS09040	COG3590	peptidase
LPH58_RS09045	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LPH58_RS09075	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LPH58_RS09095	COG0519	Catalyzes the synthesis of GMP from XMP
LPH58_RS09095	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LPH58_RS09100	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
LPH58_RS09105	COG1162	GTPase activity
LPH58_RS09115	COG3107	peptidoglycan biosynthetic process
LPH58_RS09140	COG2878	Part of a membrane complex involved in electron transport
LPH58_RS09235	COG1611	Belongs to the LOG family
LPH58_RS09240	COG4943	cyclic-guanylate-specific phosphodiesterase activity
LPH58_RS09250	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
LPH58_RS09255	COG1160	GTP binding
LPH58_RS09260	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LPH58_RS09290	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LPH58_RS09305	COG0330	HflC and HflK could
LPH58_RS09310	COG0330	HflC and HflK could
LPH58_RS09315	COG0604	alcohol dehydrogenase
LPH58_RS09345	COG1183	phosphatidylcholine synthase activity
LPH58_RS09355	COG0456	acetyltransferase
LPH58_RS09375	COG0668	transmembrane transport
LPH58_RS09380	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
LPH58_RS09395	COG1610	YqeY-like protein
LPH58_RS09400	COG1295	ribonuclease BN
LPH58_RS09405	COG0358	DNA primase activity
LPH58_RS09415	COG0180	Tryptophanyl-tRNA synthetase
LPH58_RS09425	COG1074	ATP-dependent DNA helicase activity
LPH58_RS09430	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
LPH58_RS09435	COG1127	ABC transporter
LPH58_RS09440	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LPH58_RS09445	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
LPH58_RS09460	COG2853	Lipoprotein
LPH58_RS09470	COG1116	anion transmembrane transporter activity
LPH58_RS09485	COG0531	amino acid
LPH58_RS09495	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
LPH58_RS09500	COG0861	Integral membrane protein TerC family
LPH58_RS09535	COG2205	protein histidine kinase activity
LPH58_RS09535	COG4999	Histidine kinase
LPH58_RS09535	COG3850	Histidine kinase
LPH58_RS09535	COG3437	response regulator, receiver
LPH58_RS09595	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LPH58_RS09645	COG2124	cytochrome p450
LPH58_RS09675	COG0305	Participates in initiation and elongation during chromosome replication
LPH58_RS09690	COG0667	Aldo Keto reductase
LPH58_RS09695	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
LPH58_RS09730	COG2194	sulfuric ester hydrolase activity
LPH58_RS09735	COG2124	cytochrome p450
LPH58_RS09740	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LPH58_RS09750	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LPH58_RS09760	COG0277	FAD linked oxidase domain protein
LPH58_RS09775	COG4206	TonB-dependent receptor
LPH58_RS09820	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
LPH58_RS09825	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
LPH58_RS09850	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LPH58_RS09870	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LPH58_RS09870	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LPH58_RS09890	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LPH58_RS09895	COG0488	(ABC) transporter
LPH58_RS09905	COG3011	Protein conserved in bacteria
LPH58_RS09915	COG0564	pseudouridine synthase activity
LPH58_RS09920	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LPH58_RS09940	COG1028	Short-chain dehydrogenase reductase Sdr
LPH58_RS09945	COG2969	positive regulation of protein catabolic process
LPH58_RS09950	COG0625	glutathione transferase activity
LPH58_RS09970	COG0741	lytic transglycosylase activity
LPH58_RS09980	COG1702	phosphate starvation-inducible protein PhoH
LPH58_RS09995	COG4535	Mg2 and Co2 transporter CorC
LPH58_RS10030	COG3210	domain, Protein
LPH58_RS10035	COG2831	hemolysin activation secretion protein
LPH58_RS10060	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
LPH58_RS10080	COG3115	cell septum assembly
LPH58_RS10095	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
LPH58_RS10105	COG0316	Belongs to the HesB IscA family
LPH58_RS10130	COG0167	dihydroorotate dehydrogenase activity
LPH58_RS10135	COG0812	UDP-N-acetylmuramate dehydrogenase activity
LPH58_RS10140	COG0697	spore germination
LPH58_RS10145	COG0671	phosphoesterase, PA-phosphatase related
LPH58_RS10150	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
LPH58_RS10160	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
LPH58_RS10165	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
LPH58_RS10185	COG1132	(ABC) transporter
LPH58_RS10200	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
LPH58_RS10205	COG1538	Outer membrane efflux protein
LPH58_RS10210	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LPH58_RS10220	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
LPH58_RS10235	COG4783	chaperone-mediated protein folding
LPH58_RS10245	COG0473	3-isopropylmalate dehydrogenase activity
LPH58_RS10255	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LPH58_RS10265	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
LPH58_RS10275	COG0316	Belongs to the HesB IscA family
LPH58_RS10275	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
LPH58_RS10280	COG2154	pterin-4-alpha-carbinolamine dehydratase
LPH58_RS10295	COG0564	pseudouridine synthase activity
LPH58_RS10300	COG1530	ribonuclease E activity
LPH58_RS10320	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
LPH58_RS10335	COG0488	(ABC) transporter
LPH58_RS10345	COG1278	Cold shock
LPH58_RS10360	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LPH58_RS10370	COG0049	tRNA binding
LPH58_RS10385	COG0085	RNA polymerase activity
LPH58_RS10390	COG0222	ribosome binding
LPH58_RS10405	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
LPH58_RS10410	COG0250	Participates in transcription elongation, termination and antitermination
LPH58_RS10415	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LPH58_RS10425	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LPH58_RS10445	COG0012	GTP binding
LPH58_RS10450	COG0193	aminoacyl-tRNA hydrolase activity
LPH58_RS10455	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
LPH58_RS10460	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LPH58_RS10470	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
LPH58_RS10475	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
LPH58_RS10485	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
LPH58_RS10560	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LPH58_RS10565	COG0765	amino acid transport
LPH58_RS10570	COG1126	abc transporter atp-binding protein
LPH58_RS10575	COG0765	amino acid transport
LPH58_RS10580	COG1074	ATP-dependent DNA helicase activity
LPH58_RS10590	COG2095	MarC family integral membrane protein
LPH58_RS10595	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
LPH58_RS10625	COG2132	Multicopper oxidase
LPH58_RS10635	COG0210	DNA helicase
LPH58_RS10645	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
LPH58_RS10650	COG0616	signal peptide processing
LPH58_RS10670	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
LPH58_RS10675	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LPH58_RS10680	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
LPH58_RS10690	COG2177	Part of the ABC transporter FtsEX involved in
LPH58_RS10695	COG2884	Cell division ATP-binding protein ftsE
LPH58_RS10700	COG0513	Belongs to the DEAD box helicase family
LPH58_RS10705	COG3118	belongs to the thioredoxin family
LPH58_RS10710	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
LPH58_RS10735	COG0793	Belongs to the peptidase S41A family
LPH58_RS10740	COG4942	peptidase
LPH58_RS10750	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
LPH58_RS10770	COG0493	'glutamate synthase
LPH58_RS10775	COG0067	glutamate synthase
LPH58_RS10775	COG0070	glutamate synthase
LPH58_RS10775	COG0069	glutamate synthase activity
LPH58_RS10875	COG3210	domain, Protein
LPH58_RS11015	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
LPH58_RS11025	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
LPH58_RS11030	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
LPH58_RS11145	COG1028	Short-chain dehydrogenase reductase Sdr
LPH58_RS11165	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LPH58_RS11175	COG1199	ATP-dependent helicase activity
LPH58_RS11185	COG0288	reversible hydration of carbon dioxide
LPH58_RS11190	COG0438	transferase activity, transferring glycosyl groups
LPH58_RS11205	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LPH58_RS11210	COG2011	ABC-type metal ion transport system permease component
LPH58_RS11215	COG1464	Belongs to the NlpA lipoprotein family
LPH58_RS11230	COG0508	dehydrogenase complex catalyzes the overall conversion of
LPH58_RS11235	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LPH58_RS11250	COG0626	cystathionine gamma-synthase activity
LPH58_RS11255	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LPH58_RS11260	COG0739	heme binding
LPH58_RS11265	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
LPH58_RS11270	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
LPH58_RS11295	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LPH58_RS11320	COG3525	Glycosyl hydrolase, family 20, catalytic domain
LPH58_RS11330	COG1472	Belongs to the glycosyl hydrolase 3 family
LPH58_RS11345	COG3537	Alpha-1,2-mannosidase
LPH58_RS11365	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
LPH58_RS11375	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LPH58_RS11380	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LPH58_RS11385	COG2207	Transcriptional regulator
LPH58_RS11390	COG2249	NAD(P)H dehydrogenase (quinone) activity
LPH58_RS11420	COG3588	fructose-bisphosphate aldolase
LPH58_RS11430	COG0469	pyruvate kinase activity
LPH58_RS11450	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LPH58_RS11455	COG0735	belongs to the Fur family
LPH58_RS11470	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
LPH58_RS11470	COG5297	Belongs to the glycosyl hydrolase family 6
LPH58_RS11480	COG0612	Peptidase, M16
LPH58_RS11500	COG0653	protein targeting
LPH58_RS11505	COG0739	heme binding
LPH58_RS11515	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
LPH58_RS11530	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
LPH58_RS11535	COG1181	Belongs to the D-alanine--D-alanine ligase family
LPH58_RS11540	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LPH58_RS11555	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LPH58_RS11560	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LPH58_RS11575	COG3116	cell division
LPH58_RS11580	COG0275	rRNA processing
LPH58_RS11590	COG0471	metal ion transport
LPH58_RS11590	COG3273	potassium ion transport
LPH58_RS11595	COG0220	tRNA (guanine-N7-)-methyltransferase activity
LPH58_RS11640	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LPH58_RS11665	COG0717	Belongs to the dCTP deaminase family
LPH58_RS11680	COG0860	N-Acetylmuramoyl-L-alanine amidase
LPH58_RS11685	COG0802	atpase or kinase
LPH58_RS11690	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
LPH58_RS11690	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
LPH58_RS11695	COG1570	exodeoxyribonuclease VII activity
LPH58_RS11740	COG0776	regulation of translation
LPH58_RS11745	COG0072	phenylalanine-tRNA ligase activity
LPH58_RS11745	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LPH58_RS11750	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
LPH58_RS11755	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
LPH58_RS11765	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
LPH58_RS11785	COG0745	RESPONSE REGULATOR receiver
LPH58_RS11800	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
LPH58_RS11850	COG0045	succinate-CoA ligase (ADP-forming) activity
LPH58_RS11855	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
LPH58_RS11860	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
LPH58_RS11875	COG0594	ribonuclease P activity