locus-tag	class	description
LPH40_RS00005	COG3041	Addiction module toxin RelE StbE family
LPH40_RS00010	COG3077	Addiction module antitoxin, RelB DinJ family
LPH40_RS00085	COG2337	Toxic component of a toxin-antitoxin (TA) module
LPH40_RS00145	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
LPH40_RS00185	COG2091	lysine biosynthetic process via aminoadipic acid
LPH40_RS00195	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
LPH40_RS00200	COG1301	dicarboxylic acid transport
LPH40_RS00225	COG0339	signal peptide processing
LPH40_RS00235	COG0285	dihydrofolate synthase activity
LPH40_RS00260	COG2201	protein-glutamate methylesterase activity
LPH40_RS00265	COG0643	Histidine kinase
LPH40_RS00265	COG0784	Response regulator, receiver
LPH40_RS00265	COG2198	Histidine kinase
LPH40_RS00270	COG0840	transmembrane signaling receptor activity
LPH40_RS00300	COG0751	glycine-tRNA ligase activity
LPH40_RS00310	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
LPH40_RS00310	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LPH40_RS00330	COG0727	PFAM Uncharacterised protein family (UPF0153)
LPH40_RS00345	COG0596	Alpha beta hydrolase
LPH40_RS00355	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LPH40_RS00365	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
LPH40_RS00375	COG0138	bifunctional purine biosynthesis protein purh
LPH40_RS00380	COG0151	Belongs to the GarS family
LPH40_RS00400	COG1289	transmembrane transporter activity
LPH40_RS00410	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
LPH40_RS00420	COG0302	gtp cyclohydrolase
LPH40_RS00430	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
LPH40_RS00440	COG0557	exoribonuclease II activity
LPH40_RS00450	COG3772	lysozyme
LPH40_RS00545	COG1881	PFAM PEBP family protein
LPH40_RS00550	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
LPH40_RS00555	COG3118	belongs to the thioredoxin family
LPH40_RS00565	COG0495	leucyl-tRNA aminoacylation
LPH40_RS00595	COG2951	lytic endotransglycosylase activity
LPH40_RS00740	COG3210	domain, Protein
LPH40_RS00840	COG3210	domain, Protein
LPH40_RS00855	COG1280	lysine exporter protein (LysE YggA)
LPH40_RS00875	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LPH40_RS00880	COG0277	FAD linked oxidase domain protein
LPH40_RS00885	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LPH40_RS00890	COG0531	amino acid
LPH40_RS00895	COG0531	amino acid
LPH40_RS00900	COG0235	Class ii aldolase
LPH40_RS00905	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
LPH40_RS00910	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
LPH40_RS00955	COG0131	Imidazoleglycerol-phosphate dehydratase
LPH40_RS00955	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
LPH40_RS00965	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
LPH40_RS00970	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
LPH40_RS00990	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
LPH40_RS00995	COG0083	homoserine kinase activity
LPH40_RS01000	COG0527	aspartate kinase activity
LPH40_RS01000	COG0460	homoserine dehydrogenase
LPH40_RS01010	COG0540	Belongs to the ATCase OTCase family
LPH40_RS01025	COG1686	Belongs to the peptidase S11 family
LPH40_RS01030	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
LPH40_RS01045	COG4953	penicillin-binding protein 1C
LPH40_RS01080	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LPH40_RS01105	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
LPH40_RS01110	COG1381	Involved in DNA repair and RecF pathway recombination
LPH40_RS01125	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LPH40_RS01135	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LPH40_RS01145	COG1028	Short-chain dehydrogenase reductase Sdr
LPH40_RS01160	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LPH40_RS01165	COG1506	peptidase
LPH40_RS01165	COG0823	Involved in the tonB-independent uptake of proteins
LPH40_RS01170	COG1297	OPT oligopeptide transporter protein
LPH40_RS01205	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
LPH40_RS01215	COG0318	PFAM AMP-dependent synthetase and ligase
LPH40_RS01225	COG0463	Glycosyl transferase, family 2
LPH40_RS01235	COG1475	DNA binding
LPH40_RS01240	COG1192	Involved in chromosome partitioning
LPH40_RS01255	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
LPH40_RS01270	COG1605	Chorismate mutase
LPH40_RS01270	COG0077	Prephenate dehydratase
LPH40_RS01285	COG1668	transmembrane transport
LPH40_RS01290	COG4555	ABC transporter
LPH40_RS01320	COG1309	transcriptional regulator
LPH40_RS01325	COG2226	methyltransferase
LPH40_RS01335	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LPH40_RS01350	COG2900	Belongs to the SlyX family
LPH40_RS01365	COG0386	Belongs to the glutathione peroxidase family
LPH40_RS01375	COG1131	(ABC) transporter
LPH40_RS01400	COG2850	peptidyl-arginine hydroxylation
LPH40_RS01405	COG0567	Dehydrogenase, E1 component
LPH40_RS01425	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
LPH40_RS01450	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
LPH40_RS01480	COG0583	DNA-binding transcription factor activity
LPH40_RS01485	COG3634	alkyl hydroperoxide reductase activity
LPH40_RS01495	COG5295	Hep Hag repeat protein
LPH40_RS01500	COG1450	Type ii and iii secretion system protein
LPH40_RS01515	COG3166	PFAM Fimbrial assembly family protein
LPH40_RS01520	COG3156	type II secretion system protein K
LPH40_RS01530	COG3156	type II secretion system protein K
LPH40_RS01535	COG4795	General secretion pathway protein
LPH40_RS01540	COG2165	general secretion pathway protein
LPH40_RS01545	COG4970	Tfp pilus assembly protein FimT
LPH40_RS01550	COG2165	general secretion pathway protein
LPH40_RS01555	COG1459	type II secretion system
LPH40_RS01560	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LPH40_RS01605	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LPH40_RS01620	COG1561	YicC-like family, N-terminal region
LPH40_RS01625	COG0194	GDP metabolic process
LPH40_RS01630	COG1758	RNA polymerase activity
LPH40_RS01635	COG0529	Catalyzes the synthesis of activated sulfate
LPH40_RS01635	COG2895	sulfate adenylyltransferase (ATP) activity
LPH40_RS01640	COG0175	sulfate reduction
LPH40_RS01655	COG0175	sulfate reduction
LPH40_RS01715	COG0308	aminopeptidase N
LPH40_RS01720	COG2226	methyltransferase
LPH40_RS01775	COG1959	2 iron, 2 sulfur cluster binding
LPH40_RS01780	COG0719	Fe-S assembly protein
LPH40_RS01785	COG0396	ATPase activity
LPH40_RS01790	COG0719	Fe-S assembly protein
LPH40_RS01795	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LPH40_RS01800	COG2146	nitrite reductase [NAD(P)H] activity
LPH40_RS01805	COG0297	glycogen (starch) synthase activity
LPH40_RS01810	COG0726	polysaccharide deacetylase
LPH40_RS01815	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LPH40_RS01820	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
LPH40_RS01840	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
LPH40_RS01845	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LPH40_RS01865	COG0837	glucose binding
LPH40_RS01890	COG4191	Histidine kinase
LPH40_RS01910	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LPH40_RS01915	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
LPH40_RS01930	COG1674	ftsk spoiiie
LPH40_RS01935	COG0492	ferredoxin-NADP+ reductase activity
LPH40_RS01945	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
LPH40_RS01950	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
LPH40_RS01955	COG0542	response to heat
LPH40_RS01975	COG2915	High frequency lysogenization protein hflD homolog
LPH40_RS02020	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LPH40_RS02030	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LPH40_RS02035	COG0047	phosphoribosylformylglycinamidine synthase activity
LPH40_RS02035	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LPH40_RS02045	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LPH40_RS02060	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
LPH40_RS02075	COG1137	ATPase activity
LPH40_RS02095	COG1660	Displays ATPase and GTPase activities
LPH40_RS02105	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LPH40_RS02110	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LPH40_RS02115	COG2239	Acts as a magnesium transporter
LPH40_RS02130	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LPH40_RS02155	COG1595	DNA-templated transcription, initiation
LPH40_RS02175	COG0142	geranyltranstransferase activity
LPH40_RS02185	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LPH40_RS02190	COG1845	cytochrome c oxidase, subunit III
LPH40_RS02195	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
LPH40_RS02200	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LPH40_RS02200	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LPH40_RS02210	COG1643	Atp-dependent helicase
LPH40_RS02215	COG0783	Belongs to the Dps family
LPH40_RS02220	COG0514	ATP-dependent DNA helicase (RecQ)
LPH40_RS02240	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LPH40_RS02285	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LPH40_RS02365	COG0142	geranyltranstransferase activity
LPH40_RS02370	COG1722	exodeoxyribonuclease VII activity
LPH40_RS02375	COG0037	tRNA processing
LPH40_RS02385	COG1301	dicarboxylic acid transport
LPH40_RS02390	COG0791	NLP P60 protein
LPH40_RS02395	COG0791	NLP P60 protein
LPH40_RS02405	COG2311	Membrane
LPH40_RS02430	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
LPH40_RS02445	COG0545	Peptidyl-prolyl cis-trans isomerase
LPH40_RS02450	COG0494	nUDIX hydrolase
LPH40_RS02460	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
LPH40_RS02475	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LPH40_RS02480	COG0352	thiamine-phosphate diphosphorylase activity
LPH40_RS02480	COG0351	phosphomethylpyrimidine kinase
LPH40_RS02505	COG1324	tolerance protein
LPH40_RS02540	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LPH40_RS02545	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LPH40_RS02550	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
LPH40_RS02565	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
LPH40_RS02585	COG4774	siderophore transport
LPH40_RS02610	COG1477	protein flavinylation
LPH40_RS02615	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
LPH40_RS02620	COG1555	photosystem II stabilization
LPH40_RS02635	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
LPH40_RS02645	COG0628	permease
LPH40_RS02655	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
LPH40_RS02660	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
LPH40_RS02680	COG3590	peptidase
LPH40_RS02685	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LPH40_RS02715	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LPH40_RS02735	COG0519	Catalyzes the synthesis of GMP from XMP
LPH40_RS02735	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LPH40_RS02740	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
LPH40_RS02745	COG1162	GTPase activity
LPH40_RS02755	COG3107	peptidoglycan biosynthetic process
LPH40_RS02780	COG2878	Part of a membrane complex involved in electron transport
LPH40_RS02875	COG1611	Belongs to the LOG family
LPH40_RS02880	COG4943	cyclic-guanylate-specific phosphodiesterase activity
LPH40_RS02890	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
LPH40_RS02895	COG1160	GTP binding
LPH40_RS02900	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LPH40_RS02930	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LPH40_RS02945	COG0330	HflC and HflK could
LPH40_RS02950	COG0330	HflC and HflK could
LPH40_RS02955	COG0604	alcohol dehydrogenase
LPH40_RS02985	COG1183	phosphatidylcholine synthase activity
LPH40_RS02995	COG0456	acetyltransferase
LPH40_RS03015	COG0668	transmembrane transport
LPH40_RS03020	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
LPH40_RS03035	COG1610	YqeY-like protein
LPH40_RS03040	COG1295	ribonuclease BN
LPH40_RS03045	COG0358	DNA primase activity
LPH40_RS03055	COG0180	Tryptophanyl-tRNA synthetase
LPH40_RS03065	COG1074	ATP-dependent DNA helicase activity
LPH40_RS03070	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
LPH40_RS03075	COG1127	ABC transporter
LPH40_RS03080	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LPH40_RS03085	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
LPH40_RS03100	COG2853	Lipoprotein
LPH40_RS03110	COG1116	anion transmembrane transporter activity
LPH40_RS03125	COG0531	amino acid
LPH40_RS03135	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
LPH40_RS03140	COG0861	Integral membrane protein TerC family
LPH40_RS03175	COG3437	response regulator, receiver
LPH40_RS03175	COG2205	protein histidine kinase activity
LPH40_RS03175	COG4999	Histidine kinase
LPH40_RS03175	COG3850	Histidine kinase
LPH40_RS03235	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LPH40_RS03285	COG2124	cytochrome p450
LPH40_RS03315	COG0305	Participates in initiation and elongation during chromosome replication
LPH40_RS03330	COG0667	Aldo Keto reductase
LPH40_RS03335	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
LPH40_RS03370	COG2194	sulfuric ester hydrolase activity
LPH40_RS03375	COG2124	cytochrome p450
LPH40_RS03380	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LPH40_RS03390	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LPH40_RS03400	COG0277	FAD linked oxidase domain protein
LPH40_RS03415	COG4206	TonB-dependent receptor
LPH40_RS03460	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
LPH40_RS03465	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
LPH40_RS03490	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LPH40_RS03510	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LPH40_RS03510	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LPH40_RS03530	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LPH40_RS03535	COG0488	(ABC) transporter
LPH40_RS03545	COG3011	Protein conserved in bacteria
LPH40_RS03555	COG0564	pseudouridine synthase activity
LPH40_RS03560	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LPH40_RS03580	COG1028	Short-chain dehydrogenase reductase Sdr
LPH40_RS03585	COG2969	positive regulation of protein catabolic process
LPH40_RS03590	COG0625	glutathione transferase activity
LPH40_RS03610	COG0741	lytic transglycosylase activity
LPH40_RS03620	COG1702	phosphate starvation-inducible protein PhoH
LPH40_RS03635	COG4535	Mg2 and Co2 transporter CorC
LPH40_RS03670	COG3210	domain, Protein
LPH40_RS03675	COG2831	hemolysin activation secretion protein
LPH40_RS03700	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
LPH40_RS03720	COG3115	cell septum assembly
LPH40_RS03735	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
LPH40_RS03745	COG0316	Belongs to the HesB IscA family
LPH40_RS03770	COG0167	dihydroorotate dehydrogenase activity
LPH40_RS03775	COG0812	UDP-N-acetylmuramate dehydrogenase activity
LPH40_RS03780	COG0697	spore germination
LPH40_RS03785	COG0671	phosphoesterase, PA-phosphatase related
LPH40_RS03790	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
LPH40_RS03800	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
LPH40_RS03805	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
LPH40_RS03825	COG1132	(ABC) transporter
LPH40_RS03840	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
LPH40_RS03845	COG1538	Outer membrane efflux protein
LPH40_RS03850	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LPH40_RS03860	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
LPH40_RS03875	COG4783	chaperone-mediated protein folding
LPH40_RS03885	COG0473	3-isopropylmalate dehydrogenase activity
LPH40_RS03895	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LPH40_RS03905	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
LPH40_RS03915	COG0316	Belongs to the HesB IscA family
LPH40_RS03915	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
LPH40_RS03920	COG2154	pterin-4-alpha-carbinolamine dehydratase
LPH40_RS03935	COG0564	pseudouridine synthase activity
LPH40_RS03940	COG1530	ribonuclease E activity
LPH40_RS03960	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
LPH40_RS03975	COG0488	(ABC) transporter
LPH40_RS03985	COG1278	Cold shock
LPH40_RS04000	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LPH40_RS04010	COG0049	tRNA binding
LPH40_RS04025	COG0085	RNA polymerase activity
LPH40_RS04030	COG0222	ribosome binding
LPH40_RS04045	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
LPH40_RS04050	COG0250	Participates in transcription elongation, termination and antitermination
LPH40_RS04055	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LPH40_RS04065	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LPH40_RS04085	COG0012	GTP binding
LPH40_RS04090	COG0193	aminoacyl-tRNA hydrolase activity
LPH40_RS04095	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
LPH40_RS04100	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LPH40_RS04110	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
LPH40_RS04115	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
LPH40_RS04125	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
LPH40_RS04195	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LPH40_RS04200	COG0765	amino acid transport
LPH40_RS04205	COG1126	abc transporter atp-binding protein
LPH40_RS04210	COG0765	amino acid transport
LPH40_RS04215	COG1074	ATP-dependent DNA helicase activity
LPH40_RS04225	COG2095	MarC family integral membrane protein
LPH40_RS04230	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
LPH40_RS04260	COG2132	Multicopper oxidase
LPH40_RS04270	COG0210	DNA helicase
LPH40_RS04280	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
LPH40_RS04285	COG0616	signal peptide processing
LPH40_RS04305	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
LPH40_RS04310	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LPH40_RS04315	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
LPH40_RS04325	COG2177	Part of the ABC transporter FtsEX involved in
LPH40_RS04330	COG2884	Cell division ATP-binding protein ftsE
LPH40_RS04335	COG0513	Belongs to the DEAD box helicase family
LPH40_RS04340	COG3118	belongs to the thioredoxin family
LPH40_RS04345	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
LPH40_RS04370	COG0793	Belongs to the peptidase S41A family
LPH40_RS04375	COG4942	peptidase
LPH40_RS04385	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
LPH40_RS04405	COG0493	'glutamate synthase
LPH40_RS04410	COG0070	glutamate synthase
LPH40_RS04410	COG0069	glutamate synthase activity
LPH40_RS04410	COG0067	glutamate synthase
LPH40_RS04510	COG3210	domain, Protein
LPH40_RS04650	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
LPH40_RS04660	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
LPH40_RS04665	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
LPH40_RS04785	COG1028	Short-chain dehydrogenase reductase Sdr
LPH40_RS04805	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LPH40_RS04815	COG1199	ATP-dependent helicase activity
LPH40_RS04825	COG0288	reversible hydration of carbon dioxide
LPH40_RS04830	COG0438	transferase activity, transferring glycosyl groups
LPH40_RS04845	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LPH40_RS04850	COG2011	ABC-type metal ion transport system permease component
LPH40_RS04855	COG1464	Belongs to the NlpA lipoprotein family
LPH40_RS04870	COG0508	dehydrogenase complex catalyzes the overall conversion of
LPH40_RS04875	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LPH40_RS04890	COG0626	cystathionine gamma-synthase activity
LPH40_RS04895	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LPH40_RS04900	COG0739	heme binding
LPH40_RS04905	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
LPH40_RS04910	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
LPH40_RS04935	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LPH40_RS04960	COG3525	Glycosyl hydrolase, family 20, catalytic domain
LPH40_RS04970	COG1472	Belongs to the glycosyl hydrolase 3 family
LPH40_RS04985	COG3537	Alpha-1,2-mannosidase
LPH40_RS05005	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
LPH40_RS05015	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LPH40_RS05020	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LPH40_RS05025	COG2207	Transcriptional regulator
LPH40_RS05030	COG2249	NAD(P)H dehydrogenase (quinone) activity
LPH40_RS05060	COG3588	fructose-bisphosphate aldolase
LPH40_RS05075	COG0469	pyruvate kinase activity
LPH40_RS05095	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LPH40_RS05100	COG0735	belongs to the Fur family
LPH40_RS05115	COG5297	Belongs to the glycosyl hydrolase family 6
LPH40_RS05115	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
LPH40_RS05125	COG0612	Peptidase, M16
LPH40_RS05145	COG0653	protein targeting
LPH40_RS05150	COG0739	heme binding
LPH40_RS05160	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
LPH40_RS05175	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
LPH40_RS05180	COG1181	Belongs to the D-alanine--D-alanine ligase family
LPH40_RS05185	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LPH40_RS05200	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LPH40_RS05205	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LPH40_RS05220	COG3116	cell division
LPH40_RS05225	COG0275	rRNA processing
LPH40_RS05235	COG0471	metal ion transport
LPH40_RS05235	COG3273	potassium ion transport
LPH40_RS05240	COG0220	tRNA (guanine-N7-)-methyltransferase activity
LPH40_RS05285	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LPH40_RS05310	COG0717	Belongs to the dCTP deaminase family
LPH40_RS05325	COG0860	N-Acetylmuramoyl-L-alanine amidase
LPH40_RS05330	COG0802	atpase or kinase
LPH40_RS05335	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
LPH40_RS05335	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
LPH40_RS05340	COG1570	exodeoxyribonuclease VII activity
LPH40_RS05385	COG0776	regulation of translation
LPH40_RS05390	COG0072	phenylalanine-tRNA ligase activity
LPH40_RS05390	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LPH40_RS05395	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
LPH40_RS05400	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
LPH40_RS05410	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
LPH40_RS05430	COG0745	RESPONSE REGULATOR receiver
LPH40_RS05445	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
LPH40_RS05495	COG0045	succinate-CoA ligase (ADP-forming) activity
LPH40_RS05500	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
LPH40_RS05505	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
LPH40_RS05520	COG0594	ribonuclease P activity
LPH40_RS05530	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LPH40_RS05540	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
LPH40_RS05545	COG0187	DNA topoisomerase II activity
LPH40_RS05555	COG0501	Belongs to the peptidase M48B family
LPH40_RS05600	COG0408	coproporphyrinogen oxidase activity
LPH40_RS05625	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LPH40_RS05695	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
LPH40_RS05705	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
LPH40_RS05715	COG0511	ligase activity, forming carbon-carbon bonds
LPH40_RS05720	COG0439	Biotin carboxylase
LPH40_RS05725	COG0210	DNA helicase
LPH40_RS05765	COG1040	competence protein
LPH40_RS05770	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
LPH40_RS05775	COG1752	Esterase of the alpha-beta hydrolase superfamily
LPH40_RS05780	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
LPH40_RS05795	COG2027	D-alanyl-D-alanine carboxypeptidase
LPH40_RS05830	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LPH40_RS05840	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
LPH40_RS05865	COG3121	Chaperone
LPH40_RS05870	COG3539	Fimbrial protein
LPH40_RS05875	COG1546	Belongs to the CinA family
LPH40_RS05880	COG0477	Major facilitator Superfamily
LPH40_RS05885	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LPH40_RS05890	COG1923	regulation of RNA biosynthetic process
LPH40_RS05900	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
LPH40_RS05905	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LPH40_RS05915	COG1534	Rna-binding protein
LPH40_RS05930	COG0129	dihydroxy-acid dehydratase activity
LPH40_RS05960	COG1560	Kdo2-lipid A biosynthetic process
LPH40_RS05965	COG1519	Transferase
LPH40_RS05980	COG0228	four-way junction DNA binding
LPH40_RS05985	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
LPH40_RS05990	COG0336	Belongs to the RNA methyltransferase TrmD family
LPH40_RS05995	COG0335	large ribosomal subunit rRNA binding
LPH40_RS06015	COG1393	Belongs to the ArsC family
LPH40_RS06025	COG0367	asparagine synthase
LPH40_RS06035	COG2070	2-Nitropropane dioxygenase
LPH40_RS06055	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LPH40_RS06070	COG0339	signal peptide processing
LPH40_RS06095	COG0525	valine-tRNA ligase activity
LPH40_RS06135	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LPH40_RS06160	COG4221	oxidoreductase activity
LPH40_RS06170	COG0018	arginyl-trna synthetase
LPH40_RS06175	COG2003	Belongs to the UPF0758 family
LPH40_RS06180	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
LPH40_RS06255	COG2223	nitrite transmembrane transporter activity
LPH40_RS06260	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
LPH40_RS06265	COG0739	heme binding
LPH40_RS06270	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
LPH40_RS06300	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LPH40_RS06325	COG1028	Short-chain dehydrogenase reductase Sdr
LPH40_RS06335	COG1272	protein, Hemolysin III
LPH40_RS06340	COG0463	Glycosyl transferase, family 2
LPH40_RS06345	COG0084	hydrolase, TatD family'
LPH40_RS06360	COG0509	glycine decarboxylation via glycine cleavage system
LPH40_RS06365	COG0404	The glycine cleavage system catalyzes the degradation of glycine
LPH40_RS06375	COG0330	HflC and HflK could
LPH40_RS06380	COG3956	TIGRFAM MazG family protein
LPH40_RS06385	COG1218	3'(2'),5'-bisphosphate nucleotidase
LPH40_RS06390	COG0494	nUDIX hydrolase
LPH40_RS06400	COG1385	rRNA (uridine-N3-)-methyltransferase activity
LPH40_RS06410	COG0513	Belongs to the DEAD box helicase family
LPH40_RS06415	COG0720	synthase
LPH40_RS06440	COG1981	membrane
LPH40_RS06450	COG0587	DNA-directed DNA polymerase activity
LPH40_RS06460	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
LPH40_RS06465	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LPH40_RS06480	COG0512	Glutamine amidotransferase of anthranilate synthase
LPH40_RS06485	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LPH40_RS06525	COG0006	proline dipeptidase activity
LPH40_RS06545	COG1862	Preprotein translocase
LPH40_RS06550	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LPH40_RS06555	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LPH40_RS06565	COG0617	tRNA 3'-terminal CCA addition
LPH40_RS06580	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
LPH40_RS06585	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
LPH40_RS06590	COG0166	Belongs to the GPI family
LPH40_RS06600	COG0779	Required for maturation of 30S ribosomal subunits
LPH40_RS06605	COG0195	Participates in both transcription termination and antitermination
LPH40_RS06610	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
LPH40_RS06615	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
LPH40_RS06620	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
LPH40_RS06630	COG1185	polyribonucleotide nucleotidyltransferase activity
LPH40_RS06635	COG1733	regulation of RNA biosynthetic process
LPH40_RS06640	COG0702	epimerase
LPH40_RS06655	COG0475	glutathione-regulated potassium exporter activity
LPH40_RS06685	COG2086	electron transfer activity
LPH40_RS06715	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LPH40_RS06770	COG0477	Major facilitator Superfamily
LPH40_RS06795	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LPH40_RS06800	COG0671	phosphoesterase, PA-phosphatase related
LPH40_RS06825	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LPH40_RS06835	COG0628	permease
LPH40_RS06855	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LPH40_RS06860	COG1090	epimerase
LPH40_RS06865	COG0318	PFAM AMP-dependent synthetase and ligase
LPH40_RS06885	COG1049	propionate catabolic process, 2-methylcitrate cycle
LPH40_RS06900	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
LPH40_RS06905	COG0732	type I restriction modification DNA specificity domain
LPH40_RS06920	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
LPH40_RS06955	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LPH40_RS06965	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LPH40_RS06975	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
LPH40_RS06980	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
LPH40_RS06985	COG1034	ATP synthesis coupled electron transport
LPH40_RS07020	COG1007	ATP synthesis coupled electron transport
LPH40_RS07025	COG1028	Short-chain dehydrogenase reductase Sdr
LPH40_RS07030	COG2851	Citrate transporter
LPH40_RS07045	COG0642	Histidine kinase
LPH40_RS07060	COG2205	protein histidine kinase activity
LPH40_RS07060	COG2198	Histidine kinase
LPH40_RS07060	COG0784	Response regulator, receiver
LPH40_RS07070	COG1301	dicarboxylic acid transport
LPH40_RS07075	COG0281	malic enzyme
LPH40_RS07075	COG0280	phosphate acetyltransferase
LPH40_RS07085	COG0742	ribosomal rna small subunit methyltransferase
LPH40_RS07100	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
LPH40_RS07120	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LPH40_RS07125	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
LPH40_RS07160	COG2166	iron-sulfur cluster assembly
LPH40_RS07165	COG0215	cysteine-tRNA ligase activity
LPH40_RS07185	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LPH40_RS07205	COG0165	Argininosuccinate lyase
LPH40_RS07220	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
LPH40_RS07255	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
LPH40_RS07315	COG5314	conjugation
LPH40_RS07340	COG1233	COG1233 Phytoene dehydrogenase and related
LPH40_RS07350	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LPH40_RS07365	COG1028	Short-chain dehydrogenase reductase Sdr
LPH40_RS07385	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
LPH40_RS07465	COG1914	H( )-stimulated, divalent metal cation uptake system
LPH40_RS07480	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
LPH40_RS07490	COG1946	Acyl-CoA thioesterase
LPH40_RS07570	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LPH40_RS07585	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LPH40_RS07605	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
LPH40_RS07610	COG0575	Belongs to the CDS family
LPH40_RS07650	COG2833	Protein of unknown function (DUF455)
LPH40_RS07655	COG0528	UMP kinase activity
LPH40_RS07725	COG0800	Aldolase
LPH40_RS07735	COG0363	glucosamine-6-phosphate deaminase activity
LPH40_RS07740	COG0837	glucose binding
LPH40_RS07745	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
LPH40_RS07750	COG3842	ATPase activity
LPH40_RS07770	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
LPH40_RS07785	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
LPH40_RS07795	COG4591	ABC-type transport system involved in lipoprotein release permease component
LPH40_RS07800	COG1136	(ABC) transporter
LPH40_RS07805	COG0658	competence protein
LPH40_RS07805	COG2333	competence protein COMEC
LPH40_RS07825	COG1663	tetraacyldisaccharide 4'-kinase activity
LPH40_RS07830	COG0489	protein tyrosine kinase activity
LPH40_RS07835	COG2062	phosphohistidine phosphatase, SixA
LPH40_RS07845	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LPH40_RS07890	COG0009	L-threonylcarbamoyladenylate synthase
LPH40_RS07895	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LPH40_RS07895	COG1754	DNA topoisomerase type I activity
LPH40_RS07905	COG2922	Belongs to the Smg family
LPH40_RS07910	COG0758	DNA mediated transformation
LPH40_RS07925	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LPH40_RS07935	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
LPH40_RS08000	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LPH40_RS08075	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
LPH40_RS08080	COG0505	Belongs to the CarA family
LPH40_RS08085	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LPH40_RS08090	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LPH40_RS08100	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
LPH40_RS08110	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
LPH40_RS08125	COG1024	Enoyl-CoA hydratase
LPH40_RS08130	COG0527	aspartate kinase activity
LPH40_RS08140	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
LPH40_RS08160	COG0494	nUDIX hydrolase
LPH40_RS08170	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
LPH40_RS08195	COG0312	modulator of DNA gyrase
LPH40_RS08200	COG3028	Belongs to the UPF0307 family
LPH40_RS08205	COG0312	modulator of DNA gyrase
LPH40_RS08235	COG0583	DNA-binding transcription factor activity
LPH40_RS08250	COG1064	alcohol dehydrogenase
LPH40_RS08265	COG0667	Aldo Keto reductase
LPH40_RS08295	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
LPH40_RS08325	COG0356	it plays a direct role in the translocation of protons across the membrane
LPH40_RS08350	COG0089	rRNA binding
LPH40_RS08360	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
LPH40_RS08365	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
LPH40_RS08370	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
LPH40_RS08430	COG1841	ribosomal large subunit assembly
LPH40_RS08435	COG0200	Binds to the 23S rRNA
LPH40_RS08440	COG0201	protein transport
LPH40_RS08445	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
LPH40_RS08450	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
LPH40_RS08470	COG2960	long-chain fatty acid transporting porin activity
LPH40_RS08475	COG0606	chelatase, subunit chli
LPH40_RS08480	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
LPH40_RS08495	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
LPH40_RS08510	COG0544	peptidyl-prolyl cis-trans isomerase activity
LPH40_RS08515	COG0740	serine-type endopeptidase activity
LPH40_RS08520	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
LPH40_RS08555	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LPH40_RS08560	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LPH40_RS08585	COG1187	pseudouridine synthase activity
LPH40_RS08590	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LPH40_RS08610	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LPH40_RS08645	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LPH40_RS08645	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LPH40_RS08665	COG3772	lysozyme
LPH40_RS08705	COG0625	glutathione transferase activity
LPH40_RS08715	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LPH40_RS08720	COG1217	gtp-binding protein TYPA
LPH40_RS08765	COG0842	Transport permease protein
LPH40_RS08770	COG1131	(ABC) transporter
LPH40_RS08790	COG1643	Atp-dependent helicase
LPH40_RS08800	COG1956	GAF domain-containing protein
LPH40_RS08805	COG0729	surface antigen
LPH40_RS08810	COG2911	Protein conserved in bacteria
LPH40_RS08860	COG1937	Protein conserved in bacteria
LPH40_RS08895	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
LPH40_RS08900	COG0668	transmembrane transport
LPH40_RS08930	COG2733	membrane
LPH40_RS08945	COG2921	Belongs to the UPF0250 family
LPH40_RS08950	COG0321	lipoyl(octanoyl) transferase activity
LPH40_RS08955	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
LPH40_RS08985	COG1253	flavin adenine dinucleotide binding
LPH40_RS09010	COG0504	CTP synthase activity
LPH40_RS09015	COG2877	3-deoxy-8-phosphooctulonate synthase activity
LPH40_RS09020	COG0148	phosphopyruvate hydratase activity
LPH40_RS09035	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
LPH40_RS09040	COG2840	Smr protein MutS2
LPH40_RS09050	COG0644	oxidoreductase
LPH40_RS09050	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
LPH40_RS09065	COG3218	ABC-type transport auxiliary lipoprotein component
LPH40_RS09065	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
LPH40_RS09070	COG1127	ABC transporter
LPH40_RS09075	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LPH40_RS09140	COG1077	Cell shape determining protein MreB Mrl
LPH40_RS09150	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
LPH40_RS09155	COG0768	penicillin binding
LPH40_RS09160	COG0772	Belongs to the SEDS family
LPH40_RS09170	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LPH40_RS09190	COG2894	cell division
LPH40_RS09195	COG0850	regulation of cytokinetic process
LPH40_RS09210	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
LPH40_RS09220	COG3038	cytochrome b561
LPH40_RS09225	COG2353	YceI-like domain
LPH40_RS09230	COG0784	Response regulator, receiver
LPH40_RS09230	COG5002	protein histidine kinase activity
LPH40_RS09240	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
LPH40_RS09265	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LPH40_RS09300	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
LPH40_RS09305	COG4208	sulfate ABC transporter
LPH40_RS09425	COG5532	Uncharacterized conserved protein (DUF2303)
LPH40_RS09450	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LPH40_RS09475	COG1566	PFAM secretion protein HlyD family protein
LPH40_RS09480	COG2814	Major facilitator Superfamily
LPH40_RS09485	COG2267	carboxylic ester hydrolase activity
LPH40_RS09505	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LPH40_RS09510	COG0617	tRNA 3'-terminal CCA addition
LPH40_RS09515	COG0741	lytic transglycosylase activity
LPH40_RS09590	COG1028	Short-chain dehydrogenase reductase Sdr
LPH40_RS09605	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
LPH40_RS09610	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
LPH40_RS09630	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
LPH40_RS09635	COG0483	inositol monophosphate 1-phosphatase activity
LPH40_RS09645	COG1509	lysine 2,3-aminomutase activity
LPH40_RS09655	COG0402	S-adenosylhomocysteine deaminase activity
LPH40_RS09660	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LPH40_RS09665	COG0546	phosphoglycolate phosphatase activity
LPH40_RS09680	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LPH40_RS09715	COG0436	Aminotransferase
LPH40_RS09730	COG1187	pseudouridine synthase activity
LPH40_RS09735	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
LPH40_RS09740	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
LPH40_RS09775	COG0395	ABC-type sugar transport system, permease component
LPH40_RS09790	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LPH40_RS09795	COG2957	Belongs to the agmatine deiminase family
LPH40_RS09820	COG0776	regulation of translation
LPH40_RS09830	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
LPH40_RS09845	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LPH40_RS09850	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
LPH40_RS09925	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LPH40_RS09935	COG0211	Belongs to the bacterial ribosomal protein bL27 family
LPH40_RS09940	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
LPH40_RS09945	COG0268	Binds directly to 16S ribosomal RNA
LPH40_RS09950	COG0728	peptidoglycan biosynthetic process
LPH40_RS09955	COG0196	riboflavin kinase activity
LPH40_RS09960	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
LPH40_RS09985	COG1396	sequence-specific DNA binding
LPH40_RS10040	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LPH40_RS10040	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
LPH40_RS10115	COG0436	Aminotransferase
LPH40_RS10125	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
LPH40_RS10150	COG1902	pentaerythritol trinitrate reductase activity
LPH40_RS10160	COG1335	isochorismatase
LPH40_RS10170	COG1064	alcohol dehydrogenase
LPH40_RS10175	COG0604	alcohol dehydrogenase
LPH40_RS10200	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LPH40_RS10205	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LPH40_RS10240	COG0473	3-isopropylmalate dehydrogenase activity
LPH40_RS10270	COG0438	transferase activity, transferring glycosyl groups
LPH40_RS10280	COG2244	polysaccharide biosynthetic process
LPH40_RS10285	COG0438	transferase activity, transferring glycosyl groups
LPH40_RS10300	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LPH40_RS10305	COG2954	triphosphatase activity
LPH40_RS10310	COG1472	Belongs to the glycosyl hydrolase 3 family
LPH40_RS10315	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
LPH40_RS10325	COG1278	Cold shock
LPH40_RS10350	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LPH40_RS10360	COG0497	DNA recombination
LPH40_RS10375	COG0443	Heat shock 70 kDa protein
LPH40_RS10380	COG0484	heat shock protein binding
LPH40_RS10395	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
LPH40_RS10405	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
LPH40_RS10425	COG0745	RESPONSE REGULATOR receiver
LPH40_RS10430	COG2205	protein histidine kinase activity
LPH40_RS10440	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
LPH40_RS10445	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
LPH40_RS10465	COG2967	ApaG domain
LPH40_RS10475	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LPH40_RS10480	COG0704	Plays a role in the regulation of phosphate uptake
LPH40_RS10490	COG0581	inorganic phosphate transmembrane transporter activity
LPH40_RS10495	COG0573	inorganic phosphate transmembrane transporter activity
LPH40_RS10500	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
LPH40_RS10505	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LPH40_RS10505	COG4651	solute:proton antiporter activity
LPH40_RS10515	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
LPH40_RS10525	COG0488	(ABC) transporter
LPH40_RS10550	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LPH40_RS10560	COG0489	protein tyrosine kinase activity
LPH40_RS10585	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LPH40_RS10640	COG1469	GTP cyclohydrolase I activity
LPH40_RS10650	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LPH40_RS10655	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LPH40_RS10660	COG2902	Dehydrogenase
LPH40_RS10665	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
LPH40_RS10695	COG2925	Exonuclease
LPH40_RS10715	COG0025	NhaP-type Na H and K H
LPH40_RS10735	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LPH40_RS10755	COG3079	Belongs to the UPF0149 family
LPH40_RS10760	COG0006	proline dipeptidase activity
LPH40_RS10800	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LPH40_RS10860	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LPH40_RS10885	COG3772	lysozyme
LPH40_RS10905	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LPH40_RS10905	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LPH40_RS10945	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LPH40_RS10955	COG0328	RNA-DNA hybrid ribonuclease activity
LPH40_RS10960	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LPH40_RS10980	COG0859	PFAM glycosyl transferase family 9
LPH40_RS10990	COG2943	transferase activity, transferring hexosyl groups
LPH40_RS10995	COG0400	carboxylic ester hydrolase activity
LPH40_RS11000	COG3275	phosphorelay sensor kinase activity
LPH40_RS11050	COG0463	Glycosyl transferase, family 2
LPH40_RS11060	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LPH40_RS11075	COG0392	lysyltransferase activity
LPH40_RS11075	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
LPH40_RS11080	COG0251	oxidation-reduction process
LPH40_RS11095	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
LPH40_RS11100	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LPH40_RS11105	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
LPH40_RS11110	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
LPH40_RS11130	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
LPH40_RS11180	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LPH40_RS11290	COG0582	viral genome integration into host DNA
LPH40_RS11305	COG3772	lysozyme
LPH40_RS11360	COG0640	Transcriptional regulator
LPH40_RS11375	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LPH40_RS11400	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LPH40_RS11435	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
LPH40_RS11440	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
LPH40_RS11450	COG0537	adenosine 5'-monophosphoramidase activity
LPH40_RS11470	COG0714	Associated with various cellular activities
LPH40_RS11480	COG1399	metal-binding, possibly nucleic acid-binding protein
LPH40_RS11485	COG0333	Belongs to the bacterial ribosomal protein bL32 family
LPH40_RS11490	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LPH40_RS11505	COG5297	Belongs to the glycosyl hydrolase family 6
LPH40_RS11510	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LPH40_RS11530	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
LPH40_RS11540	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LPH40_RS11545	COG1764	response to oxidative stress
LPH40_RS11550	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
LPH40_RS11555	COG2945	thiolester hydrolase activity
LPH40_RS11615	COG2353	YceI-like domain
LPH40_RS11620	COG1968	undecaprenyl-diphosphatase activity
LPH40_RS11625	COG0174	glutamine synthetase
LPH40_RS11630	COG0347	Belongs to the P(II) protein family
LPH40_RS11635	COG0004	ammonium transporteR
LPH40_RS11665	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
LPH40_RS11670	COG0084	hydrolase, TatD family'
LPH40_RS11755	COG1487	ribonuclease activity
LPH40_RS11780	COG0552	protein localization to endoplasmic reticulum
LPH40_RS11800	COG0217	transcriptional regulatory protein
LPH40_RS11815	COG3158	transport of potassium into the cell
LPH40_RS11825	COG0824	Thioesterase
LPH40_RS11830	COG0811	peptide transport
LPH40_RS11835	COG0848	biopolymer transport protein
LPH40_RS11850	COG2885	chlorophyll binding
LPH40_RS11860	COG0602	queuosine metabolic process
LPH40_RS11870	COG1515	deoxyribonuclease V activity
LPH40_RS11880	COG0386	Belongs to the glutathione peroxidase family
LPH40_RS11890	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
LPH40_RS11900	COG0406	alpha-ribazole phosphatase activity