locus-tag	class	description
CEW88_RS00010	COG0277	FAD linked oxidase domain protein
CEW88_RS00015	COG0247	lactate metabolic process
CEW88_RS00020	COG3591	Belongs to the peptidase S1B family
CEW88_RS00025	COG3591	Belongs to the peptidase S1B family
CEW88_RS00030	COG0071	Belongs to the small heat shock protein (HSP20) family
CEW88_RS00055	COG1012	belongs to the aldehyde dehydrogenase family
CEW88_RS00075	COG0437	4 iron, 4 sulfur cluster binding
CEW88_RS00080	COG0243	molybdopterin cofactor binding
CEW88_RS00095	COG0438	transferase activity, transferring glycosyl groups
CEW88_RS00140	COG0673	inositol 2-dehydrogenase activity
CEW88_RS00145	COG0489	protein tyrosine kinase activity
CEW88_RS00185	COG0438	transferase activity, transferring glycosyl groups
CEW88_RS00195	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CEW88_RS00225	COG0517	IMP dehydrogenase activity
CEW88_RS00225	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CEW88_RS00230	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
CEW88_RS00235	COG2877	3-deoxy-8-phosphooctulonate synthase activity
CEW88_RS00240	COG1346	cytolysis
CEW88_RS00245	COG1380	Effector of murein hydrolase LrgA
CEW88_RS00270	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CEW88_RS00275	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CEW88_RS00300	COG1115	amino acid carrier protein
CEW88_RS00310	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
CEW88_RS00320	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
CEW88_RS00330	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
CEW88_RS00335	COG1999	signal sequence binding
CEW88_RS00350	COG0802	atpase or kinase
CEW88_RS00355	COG3178	'Phosphotransferase
CEW88_RS00360	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CEW88_RS00365	COG2887	Belongs to the helicase family. UvrD subfamily
CEW88_RS00370	COG1074	ATP-dependent DNA helicase activity
CEW88_RS00385	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CEW88_RS00390	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CEW88_RS00410	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CEW88_RS00420	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CEW88_RS00425	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CEW88_RS00460	COG3034	peptidoglycan biosynthetic process
CEW88_RS00470	COG1132	(ABC) transporter
CEW88_RS00475	COG1132	(ABC) transporter
CEW88_RS00490	COG0494	nUDIX hydrolase
CEW88_RS00505	COG0745	RESPONSE REGULATOR receiver
CEW88_RS00515	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CEW88_RS00525	COG0137	argininosuccinate synthase activity
CEW88_RS00535	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CEW88_RS00545	COG0280	phosphate acetyltransferase
CEW88_RS00545	COG0281	malic enzyme
CEW88_RS00550	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CEW88_RS00555	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CEW88_RS00560	COG1420	regulation of RNA biosynthetic process
CEW88_RS00565	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CEW88_RS00570	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CEW88_RS00575	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CEW88_RS00590	COG0357	Ribosomal RNA small subunit methyltransferase G
CEW88_RS00595	COG0445	tRNA wobble uridine modification
CEW88_RS00600	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CEW88_RS00605	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CEW88_RS00610	COG0424	maF-like protein
CEW88_RS00615	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CEW88_RS00620	COG0237	dephospho-CoA kinase activity
CEW88_RS00625	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CEW88_RS00630	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
CEW88_RS00635	COG3030	protein affecting phage T7 exclusion by the F plasmid
CEW88_RS00650	COG2840	Smr protein MutS2
CEW88_RS00655	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
CEW88_RS00660	COG3474	cytochrome
CEW88_RS00665	COG1596	polysaccharide export
CEW88_RS00680	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CEW88_RS00685	COG1360	Flagellar Motor Protein
CEW88_RS00705	COG1706	bacterial-type flagellum-dependent cell motility
CEW88_RS00725	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CEW88_RS00750	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
CEW88_RS00760	COG4786	Flagellar basal body rod
CEW88_RS00765	COG4786	Flagellar basal body rod
CEW88_RS00770	COG1987	bacterial-type flagellum assembly
CEW88_RS00775	COG1677	Flagellar hook-basal body complex protein FliE
CEW88_RS00780	COG1558	bacterial-type flagellum-dependent cell motility
CEW88_RS00800	COG5443	negative regulation of bacterial-type flagellum assembly
CEW88_RS00840	COG2226	methyltransferase
CEW88_RS00845	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CEW88_RS00860	COG0268	Binds directly to 16S ribosomal RNA
CEW88_RS00865	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CEW88_RS00875	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CEW88_RS00935	COG0601	transmembrane transport
CEW88_RS00940	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CEW88_RS00945	COG4172	Belongs to the ABC transporter superfamily
CEW88_RS00955	COG0697	spore germination
CEW88_RS00960	COG0473	3-isopropylmalate dehydrogenase activity
CEW88_RS00975	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CEW88_RS00985	COG0066	3-isopropylmalate dehydratase activity
CEW88_RS00995	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
CEW88_RS00995	COG3264	Mechanosensitive ion channel
CEW88_RS01000	COG0183	Belongs to the thiolase family
CEW88_RS01010	COG0784	Response regulator, receiver
CEW88_RS01010	COG2198	Histidine kinase
CEW88_RS01010	COG5002	protein histidine kinase activity
CEW88_RS01015	COG3022	response to hydroperoxide
CEW88_RS01020	COG0514	ATP-dependent DNA helicase (RecQ)
CEW88_RS01030	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
CEW88_RS01040	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
CEW88_RS01070	COG0583	DNA-binding transcription factor activity
CEW88_RS01075	COG1960	acyl-CoA dehydrogenase activity
CEW88_RS01080	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CEW88_RS01090	COG0019	diaminopimelate decarboxylase activity
CEW88_RS01105	COG0165	Argininosuccinate lyase
CEW88_RS01110	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CEW88_RS01125	COG0287	Prephenate dehydrogenase
CEW88_RS01130	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CEW88_RS01135	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CEW88_RS01140	COG1335	isochorismatase
CEW88_RS01145	COG1054	Belongs to the UPF0176 family
CEW88_RS01150	COG1338	Plays a role in the flagellum-specific transport system
CEW88_RS01155	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CEW88_RS01165	COG1766	The M ring may be actively involved in energy transduction
CEW88_RS01185	COG3118	belongs to the thioredoxin family
CEW88_RS01190	COG1376	ErfK ybiS ycfS ynhG family protein
CEW88_RS01205	COG4181	ATPase activity
CEW88_RS01215	COG0483	inositol monophosphate 1-phosphatase activity
CEW88_RS01220	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CEW88_RS01220	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CEW88_RS01225	COG0509	glycine decarboxylation via glycine cleavage system
CEW88_RS01230	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CEW88_RS01235	COG1959	2 iron, 2 sulfur cluster binding
CEW88_RS01250	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CEW88_RS01260	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CEW88_RS01265	COG3128	pkhd-type hydroxylase
CEW88_RS01305	COG3842	ATPase activity
CEW88_RS01315	COG1176	ABC-type spermidine putrescine transport system, permease component I
CEW88_RS01330	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CEW88_RS01330	COG1648	precorrin-2 dehydrogenase activity
CEW88_RS01335	COG0243	molybdopterin cofactor binding
CEW88_RS01340	COG2146	nitrite reductase [NAD(P)H] activity
CEW88_RS01345	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CEW88_RS01350	COG1116	anion transmembrane transporter activity
CEW88_RS01355	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CEW88_RS01360	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CEW88_RS01365	COG1116	anion transmembrane transporter activity
CEW88_RS01365	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CEW88_RS01370	COG3707	response regulator
CEW88_RS01375	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CEW88_RS01380	COG1177	transmembrane transport
CEW88_RS01385	COG1176	ABC-type spermidine putrescine transport system, permease component I
CEW88_RS01390	COG3842	ATPase activity
CEW88_RS01400	COG1802	Transcriptional regulator
CEW88_RS01410	COG0004	ammonium transporteR
CEW88_RS01415	COG0347	Belongs to the P(II) protein family
CEW88_RS01420	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CEW88_RS01425	COG0284	orotidine-5'-phosphate decarboxylase activity
CEW88_RS01430	COG0180	Tryptophanyl-tRNA synthetase
CEW88_RS01455	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CEW88_RS01475	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CEW88_RS01480	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CEW88_RS01495	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CEW88_RS01495	COG2169	Transcriptional regulator
CEW88_RS01505	COG2186	Transcriptional regulator
CEW88_RS01510	COG0314	molybdopterin synthase activity
CEW88_RS01520	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CEW88_RS01525	COG1381	Involved in DNA repair and RecF pathway recombination
CEW88_RS01540	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CEW88_RS01545	COG0697	spore germination
CEW88_RS01550	COG0571	ribonuclease III activity
CEW88_RS01555	COG0681	Belongs to the peptidase S26 family
CEW88_RS01560	COG0736	holo-[acyl-carrier-protein] synthase activity
CEW88_RS01565	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CEW88_RS01575	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CEW88_RS01580	COG1758	RNA polymerase activity
CEW88_RS01585	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CEW88_RS01595	COG1238	metal cluster binding
CEW88_RS01600	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CEW88_RS01610	COG0328	RNA-DNA hybrid ribonuclease activity
CEW88_RS01620	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CEW88_RS01625	COG0242	peptide deformylase activity
CEW88_RS01630	COG0242	peptide deformylase activity
CEW88_RS01635	COG0242	peptide deformylase activity
CEW88_RS01640	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CEW88_RS01650	COG0435	Glutathione S-transferase
CEW88_RS01670	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CEW88_RS01685	COG1024	Enoyl-CoA hydratase
CEW88_RS01690	COG0840	transmembrane signaling receptor activity
CEW88_RS01700	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
CEW88_RS01720	COG2171	N-acyltransferase activity
CEW88_RS01730	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CEW88_RS01755	COG0288	reversible hydration of carbon dioxide
CEW88_RS01765	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CEW88_RS01770	COG0791	NLP P60 protein
CEW88_RS01795	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CEW88_RS01800	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CEW88_RS01805	COG0659	secondary active sulfate transmembrane transporter activity
CEW88_RS01810	COG0254	rRNA binding
CEW88_RS01815	COG0335	large ribosomal subunit rRNA binding
CEW88_RS01820	COG0336	Belongs to the RNA methyltransferase TrmD family
CEW88_RS01830	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CEW88_RS01840	COG0228	four-way junction DNA binding
CEW88_RS01865	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CEW88_RS01895	COG0356	it plays a direct role in the translocation of protons across the membrane
CEW88_RS01900	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CEW88_RS01905	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CEW88_RS01910	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CEW88_RS01915	COG0489	protein tyrosine kinase activity
CEW88_RS01915	COG2151	metal-sulfur cluster biosynthetic enzyme
CEW88_RS01935	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CEW88_RS01940	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CEW88_RS01945	COG0747	negative chemotaxis
CEW88_RS01950	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CEW88_RS01960	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
CEW88_RS01980	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CEW88_RS01995	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CEW88_RS02000	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CEW88_RS02005	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CEW88_RS02010	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CEW88_RS02040	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CEW88_RS02055	COG0540	Belongs to the ATCase OTCase family
CEW88_RS02060	COG0742	ribosomal rna small subunit methyltransferase
CEW88_RS02075	COG2154	pterin-4-alpha-carbinolamine dehydratase
CEW88_RS02095	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CEW88_RS02100	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
CEW88_RS02105	COG2853	Lipoprotein
CEW88_RS02120	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
CEW88_RS02125	COG0069	glutamate synthase activity
CEW88_RS02130	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CEW88_RS02135	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
CEW88_RS02185	COG0250	Participates in transcription elongation, termination and antitermination
CEW88_RS02190	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CEW88_RS02195	COG0081	regulation of translation
CEW88_RS02205	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CEW88_RS02215	COG0085	RNA polymerase activity
CEW88_RS02220	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CEW88_RS02235	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CEW88_RS02240	COG0049	tRNA binding
CEW88_RS02245	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CEW88_RS02250	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CEW88_RS02255	COG0051	transcription antitermination factor activity, RNA binding
CEW88_RS02260	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CEW88_RS02265	COG0088	Forms part of the polypeptide exit tunnel
CEW88_RS02270	COG0089	rRNA binding
CEW88_RS02275	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CEW88_RS02280	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CEW88_RS02285	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CEW88_RS02290	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CEW88_RS02295	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CEW88_RS02305	COG0255	Belongs to the universal ribosomal protein uL29 family
CEW88_RS02310	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CEW88_RS02315	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CEW88_RS02320	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CEW88_RS02325	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CEW88_RS02330	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CEW88_RS02335	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CEW88_RS02340	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CEW88_RS02345	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CEW88_RS02350	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CEW88_RS02355	COG1841	ribosomal large subunit assembly
CEW88_RS02360	COG0200	Binds to the 23S rRNA
CEW88_RS02365	COG0201	protein transport
CEW88_RS02370	COG0563	adenylate kinase activity
CEW88_RS02380	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CEW88_RS02385	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CEW88_RS02390	COG0202	RNA polymerase activity
CEW88_RS02395	COG0203	ribosomal protein L17
CEW88_RS02405	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CEW88_RS02430	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CEW88_RS02430	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CEW88_RS02435	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CEW88_RS02440	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CEW88_RS02445	COG2169	Transcriptional regulator
CEW88_RS02445	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CEW88_RS02450	COG2885	chlorophyll binding
CEW88_RS02460	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
CEW88_RS02475	COG1137	ATPase activity
CEW88_RS02480	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CEW88_RS02485	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CEW88_RS02510	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CEW88_RS02515	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CEW88_RS02545	COG0443	Heat shock 70 kDa protein
CEW88_RS02555	COG2003	Belongs to the UPF0758 family
CEW88_RS02570	COG0653	protein targeting
CEW88_RS02575	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CEW88_RS02580	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CEW88_RS02585	COG0494	nUDIX hydrolase
CEW88_RS02590	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CEW88_RS02605	COG0779	Required for maturation of 30S ribosomal subunits
CEW88_RS02630	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CEW88_RS02635	COG0142	geranyltranstransferase activity
CEW88_RS02655	COG0346	lactoylglutathione lyase activity
CEW88_RS02660	COG1028	Short-chain dehydrogenase reductase Sdr
CEW88_RS02675	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CEW88_RS02680	COG0493	'glutamate synthase
CEW88_RS02690	COG1309	transcriptional regulator
CEW88_RS02715	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CEW88_RS02720	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CEW88_RS02725	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CEW88_RS02740	COG1609	Transcriptional regulator
CEW88_RS02750	COG2755	lipolytic protein G-D-S-L family
CEW88_RS02750	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CEW88_RS02760	COG0583	DNA-binding transcription factor activity
CEW88_RS02765	COG1136	(ABC) transporter
CEW88_RS02765	COG0577	efflux transmembrane transporter activity
CEW88_RS02785	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CEW88_RS02795	COG1496	oxidoreductase activity
CEW88_RS02805	COG1522	sequence-specific DNA binding
CEW88_RS02810	COG0492	ferredoxin-NADP+ reductase activity
CEW88_RS02845	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CEW88_RS02850	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CEW88_RS02855	COG1435	thymidine kinase activity
CEW88_RS02870	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CEW88_RS02875	COG0471	metal ion transport
CEW88_RS02875	COG3273	potassium ion transport
CEW88_RS02885	COG0842	Transport permease protein
CEW88_RS02890	COG1183	phosphatidylcholine synthase activity
CEW88_RS02900	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CEW88_RS02905	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CEW88_RS02925	COG2244	polysaccharide biosynthetic process
CEW88_RS02975	COG0297	glycogen (starch) synthase activity
CEW88_RS02990	COG1960	acyl-CoA dehydrogenase activity
CEW88_RS03000	COG0318	PFAM AMP-dependent synthetase and ligase
CEW88_RS03005	COG1024	Enoyl-CoA hydratase
CEW88_RS03025	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CEW88_RS03050	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CEW88_RS03055	COG0778	Nitroreductase
CEW88_RS03060	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CEW88_RS03060	COG0072	phenylalanine-tRNA ligase activity
CEW88_RS03065	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CEW88_RS03100	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CEW88_RS03115	COG0463	Glycosyl transferase, family 2
CEW88_RS03120	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CEW88_RS03125	COG1278	Cold shock
CEW88_RS03135	COG0488	(ABC) transporter
CEW88_RS03155	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
CEW88_RS03170	COG2894	cell division
CEW88_RS03180	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CEW88_RS03205	COG1832	CoA-binding protein
CEW88_RS03210	COG0140	phosphoribosyl-ATP diphosphatase activity
CEW88_RS03215	COG0107	imidazoleglycerol-phosphate synthase activity
CEW88_RS03220	COG0737	Belongs to the 5'-nucleotidase family
CEW88_RS03240	COG1393	Belongs to the ArsC family
CEW88_RS03245	COG0116	Belongs to the methyltransferase superfamily
CEW88_RS03245	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CEW88_RS03255	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CEW88_RS03260	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CEW88_RS03265	COG0131	Imidazoleglycerol-phosphate dehydratase
CEW88_RS03285	COG0210	DNA helicase
CEW88_RS03290	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
CEW88_RS03330	COG0527	aspartate kinase activity
CEW88_RS03335	COG1028	Short-chain dehydrogenase reductase Sdr
CEW88_RS03350	COG1519	Transferase
CEW88_RS03355	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CEW88_RS03365	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CEW88_RS03365	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CEW88_RS03370	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CEW88_RS03375	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CEW88_RS03420	COG0564	pseudouridine synthase activity
CEW88_RS03445	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CEW88_RS03450	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CEW88_RS03455	COG0174	glutamine synthetase
CEW88_RS03465	COG0174	glutamine synthetase
CEW88_RS03470	COG4160	amino acid transport
CEW88_RS03475	COG4215	(ABC) transporter
CEW88_RS03500	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
CEW88_RS03510	COG0504	CTP synthase activity
CEW88_RS03540	COG0616	signal peptide processing
CEW88_RS03540	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CEW88_RS03560	COG0322	excinuclease ABC activity
CEW88_RS03570	COG0012	GTP binding
CEW88_RS03575	COG0534	Mate efflux family protein
CEW88_RS03595	COG2326	polyphosphate kinase activity
CEW88_RS03605	COG0159	tryptophan synthase activity
CEW88_RS03615	COG2084	Dehydrogenase
CEW88_RS03620	COG3395	kinase activity
CEW88_RS03625	COG0235	Class ii aldolase
CEW88_RS03630	COG3622	Belongs to the hyi family
CEW88_RS03635	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CEW88_RS03645	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CEW88_RS03655	COG0277	FAD linked oxidase domain protein
CEW88_RS03670	COG1028	Short-chain dehydrogenase reductase Sdr
CEW88_RS03675	COG2084	Dehydrogenase
CEW88_RS03680	COG1609	Transcriptional regulator
CEW88_RS03695	COG0129	dihydroxy-acid dehydratase activity
CEW88_RS03700	COG1028	Short-chain dehydrogenase reductase Sdr
CEW88_RS03705	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CEW88_RS03710	COG0697	spore germination
CEW88_RS03715	COG2721	sulfolactate sulfo-lyase activity
CEW88_RS03735	COG1802	Transcriptional regulator
CEW88_RS03795	COG0753	catalase activity
CEW88_RS03805	COG1216	Glycosyl transferase, family 2
CEW88_RS03825	COG1295	ribonuclease BN
CEW88_RS03850	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
CEW88_RS03860	COG1215	transferase activity, transferring glycosyl groups
CEW88_RS03885	COG3174	membrane
CEW88_RS03900	COG2197	response regulator
CEW88_RS03905	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CEW88_RS03945	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CEW88_RS03950	COG1120	ATPase activity
CEW88_RS03960	COG1522	sequence-specific DNA binding
CEW88_RS03970	COG2072	flavoprotein involved in K transport
CEW88_RS03995	COG1176	ABC-type spermidine putrescine transport system, permease component I
CEW88_RS04000	COG1177	transmembrane transport
CEW88_RS04005	COG3842	ATPase activity
CEW88_RS04020	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
CEW88_RS04030	COG0435	Glutathione S-transferase
CEW88_RS04035	COG2514	catechol 2,3-dioxygenase activity
CEW88_RS04045	COG0321	lipoyl(octanoyl) transferase activity
CEW88_RS04065	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CEW88_RS04070	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CEW88_RS04075	COG0667	Aldo Keto reductase
CEW88_RS04080	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CEW88_RS04130	COG2894	cell division
CEW88_RS04140	COG4964	Belongs to the GSP D family
CEW88_RS04160	COG1643	Atp-dependent helicase
CEW88_RS04185	COG1703	isobutyryl-CoA mutase activity
CEW88_RS04190	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CEW88_RS04195	COG2847	Copper chaperone PCu(A)C
CEW88_RS04200	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CEW88_RS04205	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CEW88_RS04215	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CEW88_RS04220	COG3768	UPF0283 membrane protein
CEW88_RS04230	COG3106	COG3106 Predicted ATPase
CEW88_RS04235	COG0101	tRNA pseudouridine synthase activity
CEW88_RS04240	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CEW88_RS04245	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CEW88_RS04250	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CEW88_RS04275	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CEW88_RS04295	COG0174	glutamine synthetase
CEW88_RS04300	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CEW88_RS04320	COG1674	ftsk spoiiie
CEW88_RS04325	COG3246	L-lysine catabolic process to acetate
CEW88_RS04330	COG1802	Transcriptional regulator
CEW88_RS04335	COG1028	Short-chain dehydrogenase reductase Sdr
CEW88_RS04360	COG0481	GTPase activity
CEW88_RS04370	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CEW88_RS04375	COG0583	DNA-binding transcription factor activity
CEW88_RS04380	COG0596	Alpha beta hydrolase
CEW88_RS04495	COG3590	peptidase
CEW88_RS04500	COG3596	GTP binding
CEW88_RS04505	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CEW88_RS04515	COG0745	RESPONSE REGULATOR receiver
CEW88_RS04520	COG1607	acyl-coa hydrolase
CEW88_RS04530	COG1028	Short-chain dehydrogenase reductase Sdr
CEW88_RS04535	COG0179	Fumarylacetoacetate (FAA) hydrolase
CEW88_RS04560	COG1692	metallophosphoesterase
CEW88_RS04570	COG3273	potassium ion transport
CEW88_RS04570	COG0471	metal ion transport
CEW88_RS04575	COG0217	transcriptional regulatory protein
CEW88_RS04605	COG0596	Alpha beta hydrolase
CEW88_RS04615	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CEW88_RS04635	COG0670	Belongs to the BI1 family
CEW88_RS04645	COG0583	DNA-binding transcription factor activity
CEW88_RS04655	COG1396	sequence-specific DNA binding
CEW88_RS04660	COG0483	inositol monophosphate 1-phosphatase activity
CEW88_RS04680	COG0402	S-adenosylhomocysteine deaminase activity
CEW88_RS04685	COG2239	Acts as a magnesium transporter
CEW88_RS04690	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CEW88_RS04695	COG0151	Belongs to the GarS family
CEW88_RS04700	COG1570	exodeoxyribonuclease VII activity
CEW88_RS04710	COG0741	lytic transglycosylase activity
CEW88_RS04715	COG0552	protein localization to endoplasmic reticulum
CEW88_RS04720	COG1285	pathogenesis
CEW88_RS04725	COG2917	probably involved in intracellular septation
CEW88_RS04730	COG0477	Major facilitator Superfamily
CEW88_RS04740	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CEW88_RS04755	COG0084	hydrolase, TatD family'
CEW88_RS04890	COG4373	Mu-like prophage FluMu protein gp28
CEW88_RS04925	COG4397	Mu-like prophage major head subunit gpT
CEW88_RS04990	COG2001	Belongs to the MraZ family
CEW88_RS04995	COG0275	rRNA processing
CEW88_RS05010	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CEW88_RS05020	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CEW88_RS05025	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CEW88_RS05035	COG2081	HI0933 family
CEW88_RS05045	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CEW88_RS05050	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CEW88_RS05065	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CEW88_RS05070	COG1181	Belongs to the D-alanine--D-alanine ligase family
CEW88_RS05075	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CEW88_RS05080	COG0849	cell division
CEW88_RS05085	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CEW88_RS05095	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CEW88_RS05100	COG0497	DNA recombination
CEW88_RS05105	COG0525	valine-tRNA ligase activity
CEW88_RS05115	COG0489	protein tyrosine kinase activity
CEW88_RS05125	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CEW88_RS05145	COG2197	response regulator
CEW88_RS05150	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CEW88_RS05180	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CEW88_RS05185	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CEW88_RS05190	COG0601	transmembrane transport
CEW88_RS05200	COG4172	Belongs to the ABC transporter superfamily
CEW88_RS05205	COG0850	regulation of cytokinetic process
CEW88_RS05210	COG2894	cell division
CEW88_RS05215	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
CEW88_RS05220	COG0443	Heat shock 70 kDa protein
CEW88_RS05225	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CEW88_RS05235	COG1473	amidohydrolase
CEW88_RS05240	COG1840	ABC-type Fe3 transport system, periplasmic component
CEW88_RS05245	COG0642	Histidine kinase
CEW88_RS05275	COG1695	Transcriptional regulator
CEW88_RS05285	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CEW88_RS05305	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CEW88_RS05320	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CEW88_RS05330	COG4948	Mandelate Racemase Muconate Lactonizing
CEW88_RS05335	COG3618	amidohydrolase
CEW88_RS05345	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
CEW88_RS05360	COG3842	ATPase activity
CEW88_RS05365	COG0395	ABC-type sugar transport system, permease component
CEW88_RS05370	COG1175	transmembrane transport
CEW88_RS05390	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
CEW88_RS05395	COG1028	Short-chain dehydrogenase reductase Sdr
CEW88_RS05435	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CEW88_RS05470	COG1250	3-hydroxyacyl-CoA dehydrogenase
CEW88_RS05470	COG1024	Enoyl-CoA hydratase
CEW88_RS05480	COG3750	Belongs to the UPF0335 family
CEW88_RS05490	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
CEW88_RS05515	COG0586	Pfam SNARE associated Golgi protein
CEW88_RS05520	COG2610	gluconate transmembrane transporter activity
CEW88_RS05525	COG1215	transferase activity, transferring glycosyl groups
CEW88_RS05530	COG3769	mannosylglycerate metabolic process
CEW88_RS05540	COG0583	DNA-binding transcription factor activity
CEW88_RS05545	COG1278	Cold shock
CEW88_RS05550	COG1393	Belongs to the ArsC family
CEW88_RS05555	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CEW88_RS05600	COG0386	Belongs to the glutathione peroxidase family
CEW88_RS05605	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CEW88_RS05625	COG1793	dna ligase
CEW88_RS05655	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CEW88_RS05660	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
CEW88_RS05665	COG1329	Transcriptional regulator
CEW88_RS05670	COG1252	NADH dehydrogenase
CEW88_RS05685	COG1469	GTP cyclohydrolase I activity
CEW88_RS05695	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CEW88_RS05700	COG0277	FAD linked oxidase domain protein
CEW88_RS05710	COG1764	response to oxidative stress
CEW88_RS05715	COG1846	Transcriptional regulator
CEW88_RS05760	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CEW88_RS05770	COG0271	Belongs to the BolA IbaG family
CEW88_RS05780	COG3135	benzoate transporter
CEW88_RS05785	COG0523	cobalamin synthesis protein
CEW88_RS05805	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
CEW88_RS05810	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CEW88_RS05825	COG1028	Short-chain dehydrogenase reductase Sdr
CEW88_RS05830	COG0308	aminopeptidase N
CEW88_RS05870	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CEW88_RS05885	COG2995	paraquat-inducible protein a
CEW88_RS05890	COG3008	intermembrane lipid transfer
CEW88_RS05890	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CEW88_RS05905	COG0488	(ABC) transporter
CEW88_RS05910	COG5002	protein histidine kinase activity
CEW88_RS05910	COG2176	DNA-directed DNA polymerase activity
CEW88_RS05925	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CEW88_RS05935	COG0563	adenylate kinase activity
CEW88_RS05940	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CEW88_RS05950	COG5487	UPF0391 membrane protein
CEW88_RS05955	COG0784	Response regulator, receiver
CEW88_RS05980	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CEW88_RS05995	COG1160	GTP binding
CEW88_RS06010	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CEW88_RS06015	COG3591	Belongs to the peptidase S1B family
CEW88_RS06020	COG1862	Preprotein translocase
CEW88_RS06025	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CEW88_RS06030	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CEW88_RS06035	COG3737	Protein of unknown function (DUF498/DUF598)
CEW88_RS06040	COG4133	protoheme IX ABC transporter activity
CEW88_RS06045	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CEW88_RS06050	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CEW88_RS06060	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CEW88_RS06100	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CEW88_RS06100	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CEW88_RS06115	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CEW88_RS06125	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CEW88_RS06145	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CEW88_RS06150	COG1012	belongs to the aldehyde dehydrogenase family
CEW88_RS06170	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CEW88_RS06175	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CEW88_RS06185	COG0248	Ppx GppA phosphatase
CEW88_RS06190	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
CEW88_RS06285	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CEW88_RS06310	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CEW88_RS06315	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CEW88_RS06320	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CEW88_RS06325	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CEW88_RS06330	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CEW88_RS06335	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CEW88_RS06350	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CEW88_RS06360	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CEW88_RS06370	COG2095	MarC family integral membrane protein
CEW88_RS06375	COG0488	(ABC) transporter
CEW88_RS06380	COG0105	UTP biosynthetic process
CEW88_RS06390	COG0401	homolog of Blt101
CEW88_RS06415	COG4695	Portal protein
CEW88_RS06495	COG0508	dehydrogenase complex catalyzes the overall conversion of
CEW88_RS06500	COG0022	dehydrogenase e1 component
CEW88_RS06500	COG0508	dehydrogenase complex catalyzes the overall conversion of
CEW88_RS06505	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CEW88_RS06510	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
CEW88_RS06515	COG0126	phosphoglycerate kinase activity
CEW88_RS06540	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CEW88_RS06540	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CEW88_RS06555	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CEW88_RS06560	COG0316	Belongs to the HesB IscA family
CEW88_RS06565	COG0232	Belongs to the dGTPase family. Type 2 subfamily
CEW88_RS06575	COG0018	arginyl-trna synthetase
CEW88_RS06585	COG1472	Belongs to the glycosyl hydrolase 3 family
CEW88_RS06590	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CEW88_RS06595	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CEW88_RS06610	COG0717	Belongs to the dCTP deaminase family
CEW88_RS06625	COG0776	regulation of translation
CEW88_RS06630	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CEW88_RS06635	COG0416	fatty acid biosynthetic process
CEW88_RS06640	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CEW88_RS06675	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CEW88_RS06680	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
CEW88_RS06705	COG2885	chlorophyll binding
CEW88_RS06710	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CEW88_RS06720	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CEW88_RS06740	COG0440	acetolactate synthase activity
CEW88_RS06745	COG0028	Belongs to the TPP enzyme family
CEW88_RS06765	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CEW88_RS06775	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CEW88_RS06790	COG4638	Rieske (2fe-2S)
CEW88_RS06795	COG0028	Belongs to the TPP enzyme family
CEW88_RS06805	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CEW88_RS06815	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CEW88_RS06820	COG4235	cytochrome complex assembly
CEW88_RS06825	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CEW88_RS06845	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CEW88_RS06845	COG0446	pyridine nucleotide-disulphide oxidoreductase
CEW88_RS06865	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CEW88_RS06875	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CEW88_RS06895	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CEW88_RS06905	COG0415	Belongs to the DNA photolyase family
CEW88_RS06915	COG0494	nUDIX hydrolase
CEW88_RS06925	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
CEW88_RS06925	COG3264	Mechanosensitive ion channel
CEW88_RS06930	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CEW88_RS06945	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CEW88_RS06960	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CEW88_RS06970	COG0166	Belongs to the GPI family
CEW88_RS06995	COG3108	Peptidase M15
CEW88_RS07005	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CEW88_RS07025	COG2354	Protein conserved in bacteria
CEW88_RS07030	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CEW88_RS07060	COG0033	Phosphoglucomutase
CEW88_RS07075	COG0297	glycogen (starch) synthase activity
CEW88_RS07080	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CEW88_RS07085	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CEW88_RS07090	COG0058	SHG alpha-glucan phosphorylase activity
CEW88_RS07095	COG0837	glucose binding
CEW88_RS07100	COG2723	6-phospho-beta-galactosidase activity
CEW88_RS07105	COG1609	Transcriptional regulator
CEW88_RS07110	COG1653	transport
CEW88_RS07115	COG1175	transmembrane transport
CEW88_RS07120	COG0395	ABC-type sugar transport system, permease component
CEW88_RS07125	COG0366	Alpha amylase catalytic
CEW88_RS07130	COG3842	ATPase activity
CEW88_RS07135	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CEW88_RS07145	COG1024	Enoyl-CoA hydratase
CEW88_RS07155	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
CEW88_RS07180	COG1492	cobalamin metabolic process
CEW88_RS07190	COG0538	isocitrate dehydrogenase activity
CEW88_RS07195	COG2814	Major facilitator Superfamily
CEW88_RS07210	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CEW88_RS07215	COG1960	acyl-CoA dehydrogenase activity
CEW88_RS07220	COG0438	transferase activity, transferring glycosyl groups
CEW88_RS07225	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CEW88_RS07235	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CEW88_RS07240	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CEW88_RS07245	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CEW88_RS07255	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
CEW88_RS07265	COG2166	iron-sulfur cluster assembly
CEW88_RS07270	COG0233	cytoplasmic translational termination
CEW88_RS07275	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CEW88_RS07285	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CEW88_RS07290	COG0750	zinc metalloprotease
CEW88_RS07295	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CEW88_RS07305	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CEW88_RS07310	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CEW88_RS07320	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CEW88_RS07330	COG0433	COG0433 Predicted ATPase
CEW88_RS07345	COG4166	transmembrane transport
CEW88_RS07350	COG1028	Short-chain dehydrogenase reductase Sdr
CEW88_RS07370	COG2313	pseudouridylate synthase activity
CEW88_RS07385	COG0586	Pfam SNARE associated Golgi protein
CEW88_RS07390	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CEW88_RS07395	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CEW88_RS07400	COG0052	Belongs to the universal ribosomal protein uS2 family
CEW88_RS07425	COG0745	RESPONSE REGULATOR receiver
CEW88_RS07430	COG0704	Plays a role in the regulation of phosphate uptake
CEW88_RS07435	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CEW88_RS07440	COG0581	inorganic phosphate transmembrane transporter activity
CEW88_RS07445	COG0573	inorganic phosphate transmembrane transporter activity
CEW88_RS07455	COG5002	protein histidine kinase activity
CEW88_RS07460	COG0626	cystathionine gamma-synthase activity
CEW88_RS07475	COG0194	GDP metabolic process
CEW88_RS07480	COG1561	YicC-like family, N-terminal region
CEW88_RS07490	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CEW88_RS07495	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CEW88_RS07505	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
CEW88_RS07510	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
CEW88_RS07565	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CEW88_RS07580	COG1278	Cold shock
CEW88_RS07585	COG0259	pyridoxamine-phosphate oxidase activity
CEW88_RS07590	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CEW88_RS07595	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
CEW88_RS07600	COG0702	epimerase
CEW88_RS07605	COG1733	regulation of RNA biosynthetic process
CEW88_RS07620	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CEW88_RS07630	COG2032	superoxide dismutase activity
CEW88_RS07640	COG1410	methionine synthase
CEW88_RS07640	COG0646	methionine synthase
CEW88_RS07650	COG5012	cobalamin binding
CEW88_RS07665	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CEW88_RS07670	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CEW88_RS07675	COG0134	indole-3-glycerol-phosphate synthase activity
CEW88_RS07685	COG0303	'Molybdopterin
CEW88_RS07690	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CEW88_RS07695	COG0658	competence protein
CEW88_RS07695	COG2333	competence protein COMEC
CEW88_RS07700	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CEW88_RS07705	COG0372	Belongs to the citrate synthase family
CEW88_RS07710	COG0372	Belongs to the citrate synthase family
CEW88_RS07715	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CEW88_RS07720	COG1024	Enoyl-CoA hydratase
CEW88_RS07730	COG3088	subunit of a heme lyase
CEW88_RS07735	COG1138	Cytochrome C-type biogenesis protein
CEW88_RS07745	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CEW88_RS07750	COG3743	rRNA binding
CEW88_RS07750	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CEW88_RS07775	COG1238	metal cluster binding
CEW88_RS07815	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CEW88_RS07820	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
CEW88_RS07825	COG0583	DNA-binding transcription factor activity
CEW88_RS07855	COG2059	Chromate
CEW88_RS07865	COG0114	fumarate hydratase activity
CEW88_RS07880	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CEW88_RS07920	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CEW88_RS07935	COG1376	ErfK ybiS ycfS ynhG family protein
CEW88_RS07945	COG1070	Carbohydrate kinase
CEW88_RS07970	COG1175	transmembrane transport
CEW88_RS07995	COG0805	protein transport
CEW88_RS08005	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CEW88_RS08010	COG2378	regulation of single-species biofilm formation
CEW88_RS08020	COG2353	YceI-like domain
CEW88_RS08030	COG0360	Binds together with S18 to 16S ribosomal RNA
CEW88_RS08035	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CEW88_RS08040	COG0359	binds to the 23S rRNA
CEW88_RS08050	COG0544	peptidyl-prolyl cis-trans isomerase activity
CEW88_RS08055	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
CEW88_RS08075	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CEW88_RS08085	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CEW88_RS08090	COG5265	(ABC) transporter
CEW88_RS08115	COG3588	fructose-bisphosphate aldolase
CEW88_RS08120	COG2124	cytochrome p450
CEW88_RS08130	COG0785	Cytochrome C biogenesis protein
CEW88_RS08135	COG1530	ribonuclease E activity
CEW88_RS08145	COG2084	Dehydrogenase
CEW88_RS08160	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CEW88_RS08165	COG1923	regulation of RNA biosynthetic process
CEW88_RS08170	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CEW88_RS08175	COG0569	domain protein
CEW88_RS08180	COG2204	response regulator
CEW88_RS08185	COG5000	phosphorelay sensor kinase activity
CEW88_RS08190	COG2204	response regulator
CEW88_RS08195	COG3852	Histidine kinase
CEW88_RS08200	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CEW88_RS08205	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CEW88_RS08205	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CEW88_RS08220	COG2867	negative regulation of translational initiation
CEW88_RS08225	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CEW88_RS08235	COG2010	Cytochrome c
CEW88_RS08240	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
CEW88_RS08250	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CEW88_RS08255	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CEW88_RS08265	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CEW88_RS08270	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CEW88_RS08290	COG0482	sulfurtransferase activity
CEW88_RS08305	COG2204	response regulator
CEW88_RS08315	COG0047	phosphoribosylformylglycinamidine synthase activity
CEW88_RS08320	COG1063	alcohol dehydrogenase
CEW88_RS08325	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
CEW88_RS08335	COG2326	polyphosphate kinase activity
CEW88_RS08360	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CEW88_RS08365	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CEW88_RS08375	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CEW88_RS08380	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CEW88_RS08390	COG4974	Belongs to the 'phage' integrase family
CEW88_RS08395	COG0528	UMP kinase activity
CEW88_RS08400	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CEW88_RS08415	COG1858	cytochrome C peroxidase
CEW88_RS08420	COG0741	lytic transglycosylase activity
CEW88_RS08425	COG0629	single-stranded DNA binding
CEW88_RS08440	COG4536	flavin adenine dinucleotide binding
CEW88_RS08460	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CEW88_RS08465	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CEW88_RS08565	COG2207	Transcriptional regulator
CEW88_RS08570	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CEW88_RS08615	COG0318	PFAM AMP-dependent synthetase and ligase
CEW88_RS08725	COG0714	Associated with various cellular activities
CEW88_RS08735	COG3119	arylsulfatase activity
CEW88_RS08745	COG0753	catalase activity
CEW88_RS08775	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CEW88_RS08775	COG0519	Catalyzes the synthesis of GMP from XMP
CEW88_RS08795	COG0840	transmembrane signaling receptor activity
CEW88_RS08810	COG1217	gtp-binding protein TYPA
CEW88_RS08830	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CEW88_RS08860	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CEW88_RS08870	COG0024	Methionine aminopeptidase
CEW88_RS08875	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
CEW88_RS08880	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CEW88_RS08895	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CEW88_RS08910	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
CEW88_RS08915	COG1612	heme a metabolic process
CEW88_RS08935	COG0352	thiamine-phosphate diphosphorylase activity
CEW88_RS08935	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
CEW88_RS08960	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CEW88_RS08965	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CEW88_RS08970	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CEW88_RS08990	COG2151	metal-sulfur cluster biosynthetic enzyme
CEW88_RS09000	COG0316	Belongs to the HesB IscA family
CEW88_RS09005	COG0149	triose-phosphate isomerase activity
CEW88_RS09010	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CEW88_RS09015	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CEW88_RS09020	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CEW88_RS09035	COG2124	cytochrome p450
CEW88_RS09045	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CEW88_RS09070	COG0713	ATP synthesis coupled electron transport
CEW88_RS09085	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CEW88_RS09090	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CEW88_RS09145	COG0649	NAD binding
CEW88_RS09150	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CEW88_RS09155	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CEW88_RS09165	COG1024	Enoyl-CoA hydratase
CEW88_RS09175	COG0625	glutathione transferase activity
CEW88_RS09185	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CEW88_RS09190	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CEW88_RS09200	COG1960	acyl-CoA dehydrogenase activity
CEW88_RS09215	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CEW88_RS09225	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CEW88_RS09230	COG0513	Belongs to the DEAD box helicase family
CEW88_RS09235	COG1764	response to oxidative stress
CEW88_RS09245	COG1522	sequence-specific DNA binding
CEW88_RS09255	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CEW88_RS09260	COG0175	sulfate reduction
CEW88_RS09285	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CEW88_RS09295	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
CEW88_RS09305	COG0546	phosphoglycolate phosphatase activity
CEW88_RS09310	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CEW88_RS09320	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CEW88_RS09335	COG0719	Fe-S assembly protein
CEW88_RS09340	COG0396	ATPase activity
CEW88_RS09350	COG0393	Putative heavy-metal-binding
CEW88_RS09360	COG0719	Fe-S assembly protein
CEW88_RS09370	COG1959	2 iron, 2 sulfur cluster binding
CEW88_RS09375	COG2945	thiolester hydrolase activity
CEW88_RS09390	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CEW88_RS09415	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CEW88_RS09425	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CEW88_RS09430	COG0739	heme binding
CEW88_RS09465	COG2814	Major facilitator Superfamily
CEW88_RS09475	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CEW88_RS09480	COG0215	cysteine-tRNA ligase activity
CEW88_RS09490	COG2890	protein-(glutamine-N5) methyltransferase activity
CEW88_RS09495	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CEW88_RS09510	COG0010	Belongs to the arginase family
CEW88_RS09515	COG1473	amidohydrolase
CEW88_RS09520	COG1473	amidohydrolase
CEW88_RS09525	COG3956	TIGRFAM MazG family protein
CEW88_RS09530	COG1840	ABC-type Fe3 transport system, periplasmic component
CEW88_RS09535	COG3454	Phosphonate metabolism
CEW88_RS09550	COG4778	phosphonate C-P lyase system protein PhnL
CEW88_RS09555	COG4107	phosphonate C-P lyase system protein PhnK
CEW88_RS09560	COG3627	carbon phosphorus lyase activity
CEW88_RS09570	COG3626	phosphonate metabolism
CEW88_RS09575	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
CEW88_RS09580	COG3624	Phosphonate C-P lyase system protein PhnG
CEW88_RS09585	COG2188	Transcriptional regulator
CEW88_RS09600	COG0840	transmembrane signaling receptor activity
CEW88_RS09610	COG3639	organic phosphonate transmembrane transporter activity
CEW88_RS09620	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
CEW88_RS09625	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
CEW88_RS09640	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CEW88_RS09665	COG1846	Transcriptional regulator
CEW88_RS09670	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CEW88_RS09675	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CEW88_RS09685	COG2943	transferase activity, transferring hexosyl groups
CEW88_RS09690	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
CEW88_RS09705	COG0154	amidase activity
CEW88_RS09710	COG0444	Belongs to the ABC transporter superfamily
CEW88_RS09715	COG4608	Belongs to the ABC transporter superfamily
CEW88_RS09720	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CEW88_RS09755	COG0183	Belongs to the thiolase family
CEW88_RS09760	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CEW88_RS09770	COG1414	Transcriptional regulator
CEW88_RS09785	COG0330	HflC and HflK could
CEW88_RS09790	COG0330	HflC and HflK could
CEW88_RS09800	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CEW88_RS09805	COG1760	l-serine dehydratase
CEW88_RS09830	COG3845	ABC transporter
CEW88_RS09835	COG4603	Belongs to the binding-protein-dependent transport system permease family
CEW88_RS09840	COG1079	Belongs to the binding-protein-dependent transport system permease family
CEW88_RS09845	COG0402	S-adenosylhomocysteine deaminase activity
CEW88_RS09860	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CEW88_RS09900	COG1136	(ABC) transporter
CEW88_RS09910	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CEW88_RS09920	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CEW88_RS09930	COG1132	(ABC) transporter
CEW88_RS09935	COG0354	folic acid binding
CEW88_RS09945	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CEW88_RS09965	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CEW88_RS09980	COG0405	Gamma-glutamyltransferase
CEW88_RS10005	COG0745	RESPONSE REGULATOR receiver
CEW88_RS10010	COG3800	Transcriptional regulator
CEW88_RS10010	COG1396	sequence-specific DNA binding
CEW88_RS10035	COG0410	ABC transporter
CEW88_RS10040	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CEW88_RS10055	COG0439	Biotin carboxylase
CEW88_RS10060	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
CEW88_RS10090	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CEW88_RS10095	COG0740	serine-type endopeptidase activity
CEW88_RS10100	COG1230	cation diffusion facilitator family transporter
CEW88_RS10125	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CEW88_RS10135	COG0735	belongs to the Fur family
CEW88_RS10150	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CEW88_RS10155	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CEW88_RS10160	COG1120	ATPase activity
CEW88_RS10170	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CEW88_RS10175	COG1984	allophanate hydrolase subunit 2
CEW88_RS10180	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CEW88_RS10185	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
CEW88_RS10190	COG1530	ribonuclease E activity
CEW88_RS10200	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CEW88_RS10205	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CEW88_RS10230	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CEW88_RS10245	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CEW88_RS10255	COG2954	triphosphatase activity
CEW88_RS10260	COG1192	Involved in chromosome partitioning
CEW88_RS10280	COG0358	DNA primase activity
CEW88_RS10285	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CEW88_RS10295	COG0586	Pfam SNARE associated Golgi protein
CEW88_RS10300	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CEW88_RS10305	COG0729	surface antigen
CEW88_RS10320	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CEW88_RS10330	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
CEW88_RS10340	COG0804	urea catabolic process
CEW88_RS10365	COG0832	Belongs to the urease beta subunit family
CEW88_RS10370	COG0831	urea catabolic process
CEW88_RS10375	COG0829	nickel cation binding
CEW88_RS10385	COG0800	Aldolase
CEW88_RS10390	COG3734	2-keto-3-deoxy-galactonokinase
CEW88_RS10400	COG1830	Aldolase
CEW88_RS10420	COG4221	oxidoreductase activity
CEW88_RS10430	COG0432	Pfam Uncharacterised protein family UPF0047
CEW88_RS10435	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CEW88_RS10440	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CEW88_RS10440	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CEW88_RS10445	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CEW88_RS10480	COG4166	transmembrane transport
CEW88_RS10485	COG4174	ABC transporter (Permease)
CEW88_RS10490	COG4239	(ABC) transporter, permease
CEW88_RS10495	COG4172	Belongs to the ABC transporter superfamily
CEW88_RS10500	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CEW88_RS10505	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CEW88_RS10510	COG5507	3-demethylubiquinone-9 3-methyltransferase
CEW88_RS10545	COG2010	Cytochrome c
CEW88_RS10550	COG0583	DNA-binding transcription factor activity
CEW88_RS10555	COG0348	domain, Protein
CEW88_RS10585	COG1522	sequence-specific DNA binding
CEW88_RS10590	COG0686	Belongs to the AlaDH PNT family
CEW88_RS10595	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CEW88_RS10600	COG1970	mechanosensitive ion channel activity
CEW88_RS10630	COG0768	penicillin binding
CEW88_RS10635	COG0772	Belongs to the SEDS family
CEW88_RS10640	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CEW88_RS10650	COG0659	secondary active sulfate transmembrane transporter activity
CEW88_RS10655	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
CEW88_RS10660	COG1280	lysine exporter protein (LysE YggA)
CEW88_RS10675	COG3243	poly(R)-hydroxyalkanoic acid synthase
CEW88_RS10695	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CEW88_RS10700	COG0758	DNA mediated transformation
CEW88_RS10705	COG0312	modulator of DNA gyrase
CEW88_RS10715	COG0109	protoheme IX farnesyltransferase activity
CEW88_RS10725	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
CEW88_RS10735	COG3346	SURF1 family
CEW88_RS10745	COG0612	Peptidase, M16
CEW88_RS10770	COG4134	Bacterial extracellular solute-binding protein
CEW88_RS10775	COG4135	transport system, permease component
CEW88_RS10780	COG4136	ATPase activity
CEW88_RS10785	COG1070	Carbohydrate kinase
CEW88_RS10795	COG2816	NAD+ diphosphatase activity
CEW88_RS10800	COG0737	Belongs to the 5'-nucleotidase family
CEW88_RS10810	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CEW88_RS10815	COG1116	anion transmembrane transporter activity
CEW88_RS10820	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CEW88_RS10855	COG2205	protein histidine kinase activity
CEW88_RS10855	COG5002	protein histidine kinase activity
CEW88_RS10855	COG0784	Response regulator, receiver
CEW88_RS10860	COG1215	transferase activity, transferring glycosyl groups
CEW88_RS10865	COG1216	Glycosyl transferase, family 2
CEW88_RS10925	COG1366	Belongs to the anti-sigma-factor antagonist family
CEW88_RS10935	COG0564	pseudouridine synthase activity
CEW88_RS10950	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CEW88_RS10955	COG0135	phosphoribosylanthranilate isomerase activity
CEW88_RS10965	COG0776	regulation of translation
CEW88_RS10975	COG0539	negative regulation of cytoplasmic translation
CEW88_RS10980	COG3284	Transcriptional regulator
CEW88_RS10985	COG1012	belongs to the aldehyde dehydrogenase family
CEW88_RS11005	COG2968	Membrane
CEW88_RS11015	COG0751	glycine-tRNA ligase activity
CEW88_RS11020	COG0574	Belongs to the PEP-utilizing enzyme family
CEW88_RS11020	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CEW88_RS11025	COG3409	Peptidoglycan-binding domain 1 protein
CEW88_RS11025	COG3773	Cell wall hydrolase
CEW88_RS11030	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CEW88_RS11035	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CEW88_RS11040	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CEW88_RS11045	COG0534	Mate efflux family protein
CEW88_RS11075	COG0625	glutathione transferase activity
CEW88_RS11080	COG0183	Belongs to the thiolase family
CEW88_RS11090	COG1024	Enoyl-CoA hydratase
CEW88_RS11090	COG1250	3-hydroxyacyl-CoA dehydrogenase
CEW88_RS11105	COG0604	alcohol dehydrogenase
CEW88_RS11110	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CEW88_RS11110	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CEW88_RS11120	COG0813	purine-nucleoside phosphorylase activity
CEW88_RS11160	COG2030	dehydratase
CEW88_RS11185	COG1732	Glycine betaine
CEW88_RS11190	COG1174	glycine betaine transport
CEW88_RS11195	COG1125	glycine betaine transport
CEW88_RS11200	COG1174	glycine betaine transport
CEW88_RS11205	COG0039	L-malate dehydrogenase activity
CEW88_RS11210	COG0045	succinate-CoA ligase (ADP-forming) activity
CEW88_RS11215	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CEW88_RS11220	COG0567	Dehydrogenase, E1 component
CEW88_RS11225	COG0508	dehydrogenase complex catalyzes the overall conversion of
CEW88_RS11265	COG2884	Cell division ATP-binding protein ftsE
CEW88_RS11275	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CEW88_RS11280	COG1116	anion transmembrane transporter activity
CEW88_RS11295	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CEW88_RS11310	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CEW88_RS11330	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CEW88_RS11335	COG0602	queuosine metabolic process
CEW88_RS11340	COG0720	synthase
CEW88_RS11345	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CEW88_RS11355	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CEW88_RS11360	COG0142	geranyltranstransferase activity
CEW88_RS11365	COG1722	exodeoxyribonuclease VII activity
CEW88_RS11370	COG0123	including yeast histone deacetylase and acetoin utilization protein
CEW88_RS11375	COG0745	RESPONSE REGULATOR receiver
CEW88_RS11380	COG1846	Transcriptional regulator
CEW88_RS11385	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CEW88_RS11400	COG1176	ABC-type spermidine putrescine transport system, permease component I
CEW88_RS11410	COG3842	ATPase activity
CEW88_RS11415	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CEW88_RS11430	COG0745	RESPONSE REGULATOR receiver
CEW88_RS11440	COG1185	polyribonucleotide nucleotidyltransferase activity
CEW88_RS11445	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CEW88_RS11460	COG2835	tetraacyldisaccharide 4'-kinase activity
CEW88_RS11480	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CEW88_RS11495	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CEW88_RS11500	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CEW88_RS11510	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CEW88_RS11515	COG1702	phosphate starvation-inducible protein PhoH
CEW88_RS11525	COG2885	chlorophyll binding
CEW88_RS11530	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CEW88_RS11550	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CEW88_RS11555	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CEW88_RS11560	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CEW88_RS11620	COG1061	Type III restriction enzyme res subunit
CEW88_RS11690	COG1522	sequence-specific DNA binding
CEW88_RS11700	COG0840	transmembrane signaling receptor activity
CEW88_RS11705	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CEW88_RS11710	COG4143	(ABC) transporter
CEW88_RS11720	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
CEW88_RS11745	COG2824	Alkylphosphonate utilization operon protein PhnA
CEW88_RS11750	COG1183	phosphatidylcholine synthase activity
CEW88_RS11760	COG0625	glutathione transferase activity
CEW88_RS11765	COG0459	protein refolding
CEW88_RS11770	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CEW88_RS11775	COG0697	spore germination
CEW88_RS11790	COG0339	signal peptide processing
CEW88_RS11795	COG0765	amino acid transport
CEW88_RS11805	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CEW88_RS11810	COG0756	dUTP diphosphatase activity
CEW88_RS11815	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CEW88_RS11830	COG0606	chelatase, subunit chli
CEW88_RS11835	COG0657	acetylesterase activity
CEW88_RS11845	COG0792	nuclease activity
CEW88_RS11850	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CEW88_RS11860	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
CEW88_RS11865	COG1278	Cold shock
CEW88_RS11870	COG0513	Belongs to the DEAD box helicase family
CEW88_RS11875	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CEW88_RS11885	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CEW88_RS11895	COG0180	Tryptophanyl-tRNA synthetase
CEW88_RS11910	COG2255	four-way junction helicase activity
CEW88_RS11915	COG0632	four-way junction helicase activity
CEW88_RS11940	COG0408	coproporphyrinogen oxidase activity
CEW88_RS11950	COG2813	Specifically methylates the guanine in position
CEW88_RS11955	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CEW88_RS11965	COG1686	Belongs to the peptidase S11 family
CEW88_RS11970	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CEW88_RS11980	COG1063	alcohol dehydrogenase
CEW88_RS11995	COG1047	Peptidyl-prolyl cis-trans
CEW88_RS12010	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CEW88_RS12030	COG0640	Transcriptional regulator
CEW88_RS12035	COG0318	PFAM AMP-dependent synthetase and ligase
CEW88_RS12040	COG1132	(ABC) transporter
CEW88_RS12055	COG1028	Short-chain dehydrogenase reductase Sdr
CEW88_RS12060	COG3806	Anti-sigma factor
CEW88_RS12065	COG1595	DNA-templated transcription, initiation
CEW88_RS12090	COG2135	peptidase activity
CEW88_RS12100	COG0590	tRNA wobble adenosine to inosine editing
CEW88_RS12105	COG1187	pseudouridine synthase activity
CEW88_RS12125	COG3853	Toxic anion resistance protein (TelA)
CEW88_RS12155	COG1490	D-aminoacyl-tRNA deacylase activity
CEW88_RS12175	COG1294	oxidase, subunit
CEW88_RS12185	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
CEW88_RS12190	COG4988	ABC transporter
CEW88_RS12225	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CEW88_RS12230	COG0594	ribonuclease P activity
CEW88_RS12235	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CEW88_RS12240	COG0037	tRNA processing
CEW88_RS12250	COG0706	membrane insertase activity
CEW88_RS12260	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CEW88_RS12265	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CEW88_RS12270	COG2062	phosphohistidine phosphatase, SixA
CEW88_RS12275	COG1126	abc transporter atp-binding protein
CEW88_RS12280	COG0765	amino acid transport
CEW88_RS12285	COG4597	amino acid ABC transporter
CEW88_RS12290	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CEW88_RS12300	COG0546	phosphoglycolate phosphatase activity
CEW88_RS12305	COG0564	pseudouridine synthase activity
CEW88_RS12315	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CEW88_RS12320	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CEW88_RS12325	COG0560	Phosphoserine phosphatase
CEW88_RS12340	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CEW88_RS12350	COG2217	Heavy metal translocating P-type atpase
CEW88_RS12390	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CEW88_RS12395	COG2096	Adenosyltransferase
CEW88_RS12405	COG0300	oxidoreductase activity
CEW88_RS12415	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CEW88_RS12445	COG1573	uracil-dna glycosylase
CEW88_RS12455	COG3191	aminopeptidase activity
CEW88_RS12470	COG4172	Belongs to the ABC transporter superfamily
CEW88_RS12475	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CEW88_RS12485	COG2816	NAD+ diphosphatase activity
CEW88_RS12490	COG3454	Phosphonate metabolism
CEW88_RS12495	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CEW88_RS12500	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CEW88_RS12505	COG0039	L-malate dehydrogenase activity
CEW88_RS12520	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
CEW88_RS12525	COG0745	RESPONSE REGULATOR receiver
CEW88_RS12530	COG2205	protein histidine kinase activity
CEW88_RS12540	COG1660	Displays ATPase and GTPase activities
CEW88_RS12550	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CEW88_RS12560	COG1250	3-hydroxyacyl-CoA dehydrogenase
CEW88_RS12585	COG4638	Rieske (2fe-2S)
CEW88_RS12600	COG0469	pyruvate kinase activity
CEW88_RS12605	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CEW88_RS12610	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CEW88_RS12615	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CEW88_RS12635	COG0495	leucyl-tRNA aminoacylation
CEW88_RS12655	COG0457	Tetratricopeptide repeat
CEW88_RS12660	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CEW88_RS12665	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CEW88_RS12670	COG0196	riboflavin kinase activity
CEW88_RS12675	COG2983	Belongs to the UPF0260 family
CEW88_RS12705	COG0436	Aminotransferase
CEW88_RS12710	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CEW88_RS12715	COG0557	exoribonuclease II activity
CEW88_RS12725	COG2378	regulation of single-species biofilm formation
CEW88_RS12730	COG2951	lytic endotransglycosylase activity
CEW88_RS12740	COG1051	belongs to the nudix hydrolase family
CEW88_RS12745	COG0793	Belongs to the peptidase S41A family
CEW88_RS12755	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CEW88_RS12760	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CEW88_RS12800	COG1872	DUF167
CEW88_RS12805	COG0778	Nitroreductase
CEW88_RS12820	COG0346	lactoylglutathione lyase activity
CEW88_RS12845	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CEW88_RS12850	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CEW88_RS12855	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CEW88_RS12890	COG0725	ABC transporter, periplasmic molybdate-binding protein
CEW88_RS12895	COG4149	molybdate abc transporter
CEW88_RS12900	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
CEW88_RS12930	COG1266	CAAX protease self-immunity
CEW88_RS12935	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CEW88_RS12940	COG0285	dihydrofolate synthase activity
CEW88_RS12945	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
CEW88_RS12950	COG2271	Major facilitator Superfamily
CEW88_RS12955	COG2226	methyltransferase
CEW88_RS12955	COG1073	alpha beta
CEW88_RS12965	COG1671	Belongs to the UPF0178 family
CEW88_RS12970	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
CEW88_RS12975	COG0679	Auxin Efflux Carrier
CEW88_RS12985	COG1131	(ABC) transporter
CEW88_RS13010	COG1028	Short-chain dehydrogenase reductase Sdr
CEW88_RS13020	COG0714	Associated with various cellular activities
CEW88_RS13065	COG1473	amidohydrolase
CEW88_RS13110	COG1074	ATP-dependent DNA helicase activity
CEW88_RS13155	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CEW88_RS13180	COG1079	Belongs to the binding-protein-dependent transport system permease family
CEW88_RS13185	COG4603	Belongs to the binding-protein-dependent transport system permease family
CEW88_RS13190	COG3845	ABC transporter
CEW88_RS13200	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CEW88_RS13225	COG2900	Belongs to the SlyX family
CEW88_RS13235	COG0124	histidyl-tRNA synthetase
CEW88_RS13245	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CEW88_RS13250	COG0625	glutathione transferase activity
CEW88_RS13255	COG1201	RNA secondary structure unwinding
CEW88_RS13265	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CEW88_RS13275	COG2759	Belongs to the formate--tetrahydrofolate ligase family
CEW88_RS13285	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CEW88_RS13290	COG0037	tRNA processing
CEW88_RS13300	COG2885	chlorophyll binding
CEW88_RS13305	COG0823	Involved in the tonB-independent uptake of proteins
CEW88_RS13325	COG0824	Thioesterase
CEW88_RS13335	COG1403	HNH endonuclease
CEW88_RS13350	COG4948	Mandelate Racemase Muconate Lactonizing
CEW88_RS13365	COG4067	protein conserved in archaea
CEW88_RS13365	COG0189	ligase activity
CEW88_RS13370	COG0129	dihydroxy-acid dehydratase activity
CEW88_RS13375	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
CEW88_RS13390	COG0825	malonyl-CoA metabolic process
CEW88_RS13425	COG1116	anion transmembrane transporter activity
CEW88_RS13435	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CEW88_RS13440	COG0601	transmembrane transport
CEW88_RS13455	COG0747	negative chemotaxis
CEW88_RS13460	COG0601	transmembrane transport
CEW88_RS13465	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CEW88_RS13475	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CEW88_RS13480	COG1120	ATPase activity
CEW88_RS13545	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CEW88_RS13550	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CEW88_RS13560	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CEW88_RS13560	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CEW88_RS13570	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CEW88_RS13575	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CEW88_RS13590	COG4598	ABC transporter
CEW88_RS13595	COG0765	amino acid transport
CEW88_RS13600	COG0765	amino acid transport
CEW88_RS13605	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
CEW88_RS13610	COG0277	FAD linked oxidase domain protein
CEW88_RS13615	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
CEW88_RS13625	COG2986	histidine ammonia-lyase
CEW88_RS13630	COG1228	amidohydrolase
CEW88_RS13640	COG0628	permease
CEW88_RS13650	COG1295	ribonuclease BN
CEW88_RS13655	COG1597	lipid kinase activity
CEW88_RS13680	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CEW88_RS13690	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CEW88_RS13695	COG0442	prolyl-tRNA aminoacylation
CEW88_RS13700	COG0628	permease
CEW88_RS13710	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CEW88_RS13715	COG0248	Ppx GppA phosphatase
CEW88_RS13730	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CEW88_RS13745	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CEW88_RS13745	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CEW88_RS13755	COG4770	biotin carboxylase activity
CEW88_RS13780	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CEW88_RS13790	COG3800	Transcriptional regulator
CEW88_RS13790	COG1396	sequence-specific DNA binding
CEW88_RS13800	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CEW88_RS13805	COG0154	amidase activity
CEW88_RS13815	COG3023	N-Acetylmuramoyl-L-alanine amidase
CEW88_RS13840	COG0505	Belongs to the CarA family
CEW88_RS13850	COG1802	Transcriptional regulator
CEW88_RS13870	COG0741	lytic transglycosylase activity
CEW88_RS13875	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CEW88_RS13880	COG0612	Peptidase, M16
CEW88_RS13885	COG0612	Peptidase, M16
CEW88_RS13895	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CEW88_RS13915	COG0138	bifunctional purine biosynthesis protein purh
CEW88_RS13925	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CEW88_RS13925	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CEW88_RS13940	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CEW88_RS13945	COG3698	Phosphodiester glycosidase
CEW88_RS13950	COG0312	modulator of DNA gyrase
CEW88_RS13955	COG1218	3'(2'),5'-bisphosphate nucleotidase
CEW88_RS13965	COG1519	Transferase
CEW88_RS13970	COG1663	tetraacyldisaccharide 4'-kinase activity
CEW88_RS13980	COG0450	alkyl hydroperoxide reductase
CEW88_RS13990	COG2814	Major facilitator Superfamily
CEW88_RS13995	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CEW88_RS14005	COG0346	lactoylglutathione lyase activity
CEW88_RS14030	COG1805	sodium ion transport
CEW88_RS14040	COG1477	protein flavinylation
CEW88_RS14085	COG0583	DNA-binding transcription factor activity
CEW88_RS14105	COG0306	phosphate transporter
CEW88_RS14125	COG1309	transcriptional regulator
CEW88_RS14145	COG1250	3-hydroxyacyl-CoA dehydrogenase
CEW88_RS14155	COG3254	rhamnose metabolic process
CEW88_RS14160	COG1172	Belongs to the binding-protein-dependent transport system permease family
CEW88_RS14165	COG1172	Belongs to the binding-protein-dependent transport system permease family
CEW88_RS14170	COG1129	ABC transporter
CEW88_RS14185	COG1028	Short-chain dehydrogenase reductase Sdr
CEW88_RS14185	COG3347	Dehydrogenase
CEW88_RS14190	COG4952	isomerase
CEW88_RS14195	COG1475	DNA binding
CEW88_RS14200	COG1192	Involved in chromosome partitioning
CEW88_RS14210	COG1879	ABC-type sugar transport system periplasmic component
CEW88_RS14215	COG1129	ABC transporter
CEW88_RS14220	COG1172	Belongs to the binding-protein-dependent transport system permease family
CEW88_RS14225	COG1172	Belongs to the binding-protein-dependent transport system permease family
CEW88_RS14230	COG2186	Transcriptional regulator
CEW88_RS14240	COG4213	ABC transporter substrate-binding protein
CEW88_RS14250	COG4214	carbohydrate transport
CEW88_RS14255	COG0129	dihydroxy-acid dehydratase activity
CEW88_RS14270	COG2017	converts alpha-aldose to the beta-anomer
CEW88_RS14280	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CEW88_RS14305	COG0811	peptide transport
CEW88_RS14325	COG1021	2,3-dihydroxybenzoate-AMP ligase
CEW88_RS14335	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
CEW88_RS14335	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CEW88_RS14350	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CEW88_RS14370	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CEW88_RS14390	COG0745	RESPONSE REGULATOR receiver
CEW88_RS14400	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CEW88_RS14420	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CEW88_RS14450	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CEW88_RS14455	COG1335	isochorismatase
CEW88_RS14460	COG0251	oxidation-reduction process
CEW88_RS14465	COG2267	carboxylic ester hydrolase activity
CEW88_RS14485	COG2951	lytic endotransglycosylase activity
CEW88_RS14530	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
CEW88_RS14535	COG3257	ureidoglycine aminohydrolase activity
CEW88_RS14545	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CEW88_RS14550	COG2897	thiosulfate sulfurtransferase activity
CEW88_RS14575	COG1012	belongs to the aldehyde dehydrogenase family
CEW88_RS14580	COG0799	negative regulation of ribosome biogenesis
CEW88_RS14585	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CEW88_RS14590	COG1968	undecaprenyl-diphosphatase activity
CEW88_RS14610	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CEW88_RS14620	COG1535	isochorismatase
CEW88_RS14620	COG3433	isochorismatase activity
CEW88_RS14640	COG1028	Short-chain dehydrogenase reductase Sdr
CEW88_RS14645	COG2391	methyltransferase activity
CEW88_RS14655	COG2814	Major facilitator Superfamily
CEW88_RS14660	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CEW88_RS14670	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CEW88_RS14695	COG2954	triphosphatase activity
CEW88_RS14700	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CEW88_RS14710	COG1194	a g-specific adenine glycosylase
CEW88_RS14725	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
CEW88_RS14730	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
CEW88_RS14735	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CEW88_RS14740	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CEW88_RS14775	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CEW88_RS14780	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CEW88_RS14800	COG2321	neutral zinc metallopeptidase
CEW88_RS14815	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
CEW88_RS14820	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CEW88_RS14820	COG0574	Belongs to the PEP-utilizing enzyme family
CEW88_RS14830	COG1115	amino acid carrier protein
CEW88_RS14835	COG1522	sequence-specific DNA binding
CEW88_RS14850	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CEW88_RS14875	COG0084	hydrolase, TatD family'
CEW88_RS14885	COG2115	Belongs to the xylose isomerase family
CEW88_RS14890	COG1129	ABC transporter
CEW88_RS14895	COG4214	carbohydrate transport
CEW88_RS14900	COG4213	ABC transporter substrate-binding protein
CEW88_RS14905	COG1846	Transcriptional regulator
CEW88_RS14905	COG1940	carbohydrate kinase activity
CEW88_RS14915	COG1858	cytochrome C peroxidase
CEW88_RS14925	COG0395	ABC-type sugar transport system, permease component
CEW88_RS14930	COG1175	transmembrane transport
CEW88_RS14965	COG2308	Evidence 4 Homologs of previously reported genes of
CEW88_RS14985	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
CEW88_RS14990	COG2201	protein-glutamate methylesterase activity
CEW88_RS15000	COG0745	RESPONSE REGULATOR receiver
CEW88_RS15005	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CEW88_RS15010	COG0835	chemotaxis
CEW88_RS15020	COG0745	RESPONSE REGULATOR receiver
CEW88_RS15045	COG0133	tryptophan synthase activity
CEW88_RS15055	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CEW88_RS15060	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CEW88_RS15070	COG4206	TonB-dependent receptor
CEW88_RS15080	COG1136	(ABC) transporter
CEW88_RS15090	COG1785	Belongs to the alkaline phosphatase family
CEW88_RS15115	COG3250	beta-galactosidase activity
CEW88_RS15125	COG3237	CsbD-like
CEW88_RS15150	COG0187	DNA topoisomerase II activity
CEW88_RS15175	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CEW88_RS15205	COG1846	Transcriptional regulator
CEW88_RS15235	COG3119	arylsulfatase activity
CEW88_RS15240	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CEW88_RS15250	COG0483	inositol monophosphate 1-phosphatase activity
CEW88_RS15275	COG2358	TRAP transporter, solute receptor (TAXI family
CEW88_RS15285	COG0405	Gamma-glutamyltransferase
CEW88_RS15290	COG4608	Belongs to the ABC transporter superfamily
CEW88_RS15295	COG0444	Belongs to the ABC transporter superfamily
CEW88_RS15300	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CEW88_RS15305	COG0601	transmembrane transport
CEW88_RS15315	COG1802	Transcriptional regulator
CEW88_RS15330	COG0784	Response regulator, receiver
CEW88_RS15340	COG3920	Histidine kinase
CEW88_RS15370	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CEW88_RS15375	COG1012	belongs to the aldehyde dehydrogenase family
CEW88_RS15380	COG1522	sequence-specific DNA binding
CEW88_RS15390	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CEW88_RS15395	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CEW88_RS15400	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CEW88_RS15405	COG0589	response to stress
CEW88_RS15415	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CEW88_RS15420	COG2423	ornithine cyclodeaminase activity
CEW88_RS15425	COG0006	proline dipeptidase activity
CEW88_RS15445	COG0343	queuine tRNA-ribosyltransferase activity
CEW88_RS15450	COG1902	pentaerythritol trinitrate reductase activity
CEW88_RS15455	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CEW88_RS15495	COG3750	Belongs to the UPF0335 family
CEW88_RS15575	COG4695	Portal protein
CEW88_RS15720	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CEW88_RS15725	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CEW88_RS15730	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CEW88_RS15745	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CEW88_RS15750	COG3842	ATPase activity
CEW88_RS15760	COG1177	transmembrane transport
CEW88_RS15770	COG4172	Belongs to the ABC transporter superfamily
CEW88_RS15780	COG0747	negative chemotaxis
CEW88_RS15790	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CEW88_RS15830	COG2132	Multicopper oxidase
CEW88_RS15835	COG2132	Multicopper oxidase
CEW88_RS15850	COG1034	ATP synthesis coupled electron transport
CEW88_RS15870	COG0395	ABC-type sugar transport system, permease component
CEW88_RS15875	COG0165	Argininosuccinate lyase
CEW88_RS15880	COG3842	ATPase activity
CEW88_RS15890	COG0363	glucosamine-6-phosphate deaminase activity
CEW88_RS15895	COG2186	Transcriptional regulator
CEW88_RS15910	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CEW88_RS15915	COG0698	ribose 5-phosphate isomerase
CEW88_RS15930	COG0583	DNA-binding transcription factor activity
CEW88_RS15945	COG2086	electron transfer activity
CEW88_RS15955	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CEW88_RS15970	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CEW88_RS15970	COG0446	pyridine nucleotide-disulphide oxidoreductase
CEW88_RS15980	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CEW88_RS16000	COG0673	inositol 2-dehydrogenase activity
CEW88_RS16015	COG4989	oxidoreductase activity
CEW88_RS16045	COG0583	DNA-binding transcription factor activity
CEW88_RS16100	COG1473	amidohydrolase
CEW88_RS16105	COG0583	DNA-binding transcription factor activity
CEW88_RS16115	COG1012	belongs to the aldehyde dehydrogenase family
CEW88_RS16130	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CEW88_RS16195	COG0556	nucleotide-excision repair
CEW88_RS16225	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CEW88_RS16270	COG3842	ATPase activity
CEW88_RS16280	COG1175	transmembrane transport
CEW88_RS16285	COG0395	ABC-type sugar transport system, permease component
CEW88_RS16290	COG3842	ATPase activity
CEW88_RS16310	COG4251	negative regulation of phosphorylation
CEW88_RS16320	COG0587	DNA-directed DNA polymerase activity
CEW88_RS16335	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
CEW88_RS16360	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
CEW88_RS16370	COG0800	Aldolase
CEW88_RS16375	COG0129	dihydroxy-acid dehydratase activity
CEW88_RS16385	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CEW88_RS16395	COG1320	monovalent cation:proton antiporter activity
CEW88_RS16400	COG2212	antiporter activity
CEW88_RS16405	COG1863	multisubunit Na H antiporter MnhE subunit
CEW88_RS16410	COG0651	ATP synthesis coupled electron transport
CEW88_RS16415	COG1006	Multisubunit Na H antiporter MnhC subunit
CEW88_RS16420	COG2111	Na H antiporter
CEW88_RS16420	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CEW88_RS16425	COG3842	ATPase activity
CEW88_RS16490	COG1028	Short-chain dehydrogenase reductase Sdr
CEW88_RS16495	COG4335	DNA alkylation repair
CEW88_RS16500	COG3180	Ammonia monooxygenase
CEW88_RS16505	COG2863	cytochrome
CEW88_RS16515	COG0156	8-amino-7-oxononanoate synthase activity
CEW88_RS16530	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CEW88_RS16535	COG0737	Belongs to the 5'-nucleotidase family
CEW88_RS16540	COG3258	Cytochrome c
CEW88_RS16565	COG0785	Cytochrome C biogenesis protein
CEW88_RS16580	COG2391	methyltransferase activity
CEW88_RS16590	COG1012	belongs to the aldehyde dehydrogenase family
CEW88_RS16595	COG1177	transmembrane transport
CEW88_RS16600	COG1176	ABC-type spermidine putrescine transport system, permease component I
CEW88_RS16605	COG3842	ATPase activity
CEW88_RS16610	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CEW88_RS16615	COG0583	DNA-binding transcription factor activity
CEW88_RS16625	COG1522	sequence-specific DNA binding
CEW88_RS16655	COG0583	DNA-binding transcription factor activity
CEW88_RS16660	COG0402	S-adenosylhomocysteine deaminase activity
CEW88_RS16670	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CEW88_RS16670	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
CEW88_RS16680	COG1473	amidohydrolase
CEW88_RS16690	COG0697	spore germination
CEW88_RS16700	COG4191	Histidine kinase
CEW88_RS16715	COG2358	TRAP transporter, solute receptor (TAXI family
CEW88_RS16720	COG1049	propionate catabolic process, 2-methylcitrate cycle
CEW88_RS16730	COG2080	2 iron, 2 sulfur cluster binding
CEW88_RS16735	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
CEW88_RS16740	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CEW88_RS16745	COG1132	(ABC) transporter
CEW88_RS16750	COG0438	transferase activity, transferring glycosyl groups
CEW88_RS16755	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CEW88_RS16775	COG1304	FMN binding
CEW88_RS16800	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CEW88_RS16805	COG1214	PFAM Peptidase M22, glycoprotease
CEW88_RS16815	COG1744	ABC transporter substrate-binding protein PnrA-like
CEW88_RS16820	COG3845	ABC transporter
CEW88_RS16825	COG4603	Belongs to the binding-protein-dependent transport system permease family
CEW88_RS16830	COG1079	Belongs to the binding-protein-dependent transport system permease family
CEW88_RS16835	COG0730	response to heat
CEW88_RS16870	COG1022	Amp-dependent synthetase and ligase
CEW88_RS16905	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
CEW88_RS16925	COG2183	response to ionizing radiation
CEW88_RS16930	COG2197	response regulator
CEW88_RS16935	COG4585	Histidine kinase
CEW88_RS16940	COG1879	ABC-type sugar transport system periplasmic component
CEW88_RS16945	COG1129	ABC transporter
CEW88_RS16950	COG1172	Belongs to the binding-protein-dependent transport system permease family
CEW88_RS16960	COG3386	PFAM SMP-30 Gluconolaconase
CEW88_RS16965	COG0693	protein deglycase activity
CEW88_RS16970	COG0583	DNA-binding transcription factor activity
CEW88_RS16975	COG1309	transcriptional regulator
CEW88_RS17000	COG1546	Belongs to the CinA family
CEW88_RS17000	COG1058	Belongs to the CinA family
CEW88_RS17010	COG3185	4-Hydroxyphenylpyruvate dioxygenase
CEW88_RS17010	COG1082	Xylose isomerase domain protein TIM barrel
CEW88_RS17015	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CEW88_RS17025	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CEW88_RS17030	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CEW88_RS17070	COG1780	Probably involved in ribonucleotide reductase function
CEW88_RS17085	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
CEW88_RS17095	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CEW88_RS17120	COG0754	glutathionylspermidine amidase activity
CEW88_RS17140	COG2832	Protein of unknown function (DUF454)
CEW88_RS17150	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CEW88_RS17160	COG2116	formate transmembrane transporter activity
CEW88_RS17165	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
CEW88_RS17170	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
CEW88_RS17180	COG3842	ATPase activity
CEW88_RS17185	COG0395	ABC-type sugar transport system, permease component
CEW88_RS17200	COG1609	Transcriptional regulator
CEW88_RS17205	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CEW88_RS17210	COG1127	ABC transporter
CEW88_RS17230	COG4175	Glycine betaine
CEW88_RS17245	COG1309	transcriptional regulator
CEW88_RS17265	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CEW88_RS17270	COG2011	ABC-type metal ion transport system permease component
CEW88_RS17275	COG1464	Belongs to the NlpA lipoprotein family
CEW88_RS17285	COG0446	pyridine nucleotide-disulphide oxidoreductase
CEW88_RS17285	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CEW88_RS17315	COG0281	malic enzyme
CEW88_RS17315	COG0280	phosphate acetyltransferase
CEW88_RS17325	COG1227	inorganic diphosphatase activity
CEW88_RS17340	COG2030	dehydratase
CEW88_RS17350	COG1309	transcriptional regulator
CEW88_RS17360	COG0730	response to heat
CEW88_RS17365	COG0024	Methionine aminopeptidase
CEW88_RS17370	COG0668	transmembrane transport
CEW88_RS17375	COG1489	DNA binding
CEW88_RS17380	COG1349	DNA-binding transcription factor activity
CEW88_RS17390	COG3842	ATPase activity
CEW88_RS17395	COG3842	ATPase activity
CEW88_RS17400	COG1175	transmembrane transport
CEW88_RS17405	COG0395	ABC-type sugar transport system, permease component
CEW88_RS17420	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CEW88_RS17425	COG1028	Short-chain dehydrogenase reductase Sdr
CEW88_RS17430	COG1177	transmembrane transport
CEW88_RS17435	COG1176	ABC-type spermidine putrescine transport system, permease component I
CEW88_RS17490	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CEW88_RS17525	COG4948	Mandelate Racemase Muconate Lactonizing
CEW88_RS17545	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CEW88_RS17565	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CEW88_RS17580	COG0752	glycyl-tRNA synthetase alpha subunit
CEW88_RS17590	COG0181	hydroxymethylbilane synthase activity
CEW88_RS17595	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CEW88_RS17600	COG0697	spore germination
CEW88_RS17605	COG1131	(ABC) transporter
CEW88_RS17610	COG0842	Transport permease protein
CEW88_RS17650	COG0860	N-Acetylmuramoyl-L-alanine amidase
CEW88_RS17655	COG0436	Aminotransferase
CEW88_RS17675	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CEW88_RS17685	COG0156	8-amino-7-oxononanoate synthase activity
CEW88_RS17715	COG0418	dihydroorotase activity
CEW88_RS17720	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CEW88_RS17735	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CEW88_RS17740	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CEW88_RS17745	COG1127	ABC transporter
CEW88_RS17775	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CEW88_RS17785	COG4221	oxidoreductase activity
CEW88_RS17795	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CEW88_RS17800	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CEW88_RS17815	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CEW88_RS17820	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CEW88_RS17825	COG1845	cytochrome c oxidase, subunit III
CEW88_RS17830	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
CEW88_RS17845	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CEW88_RS17855	COG0193	aminoacyl-tRNA hydrolase activity
CEW88_RS17890	COG1114	Component of the transport system for branched-chain amino acids
CEW88_RS17900	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CEW88_RS17920	COG5425	PFAM Usg family protein
CEW88_RS17925	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CEW88_RS17945	COG3220	belongs to the UPF0276 family
CEW88_RS17975	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CEW88_RS17985	COG1162	GTPase activity
CEW88_RS18000	COG1940	carbohydrate kinase activity
CEW88_RS18005	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CEW88_RS18010	COG0673	inositol 2-dehydrogenase activity
CEW88_RS18015	COG1175	transmembrane transport
CEW88_RS18020	COG0395	ABC-type sugar transport system, permease component
CEW88_RS18030	COG3842	ATPase activity
CEW88_RS18045	COG1737	Transcriptional regulator
CEW88_RS18065	COG0363	glucosamine-6-phosphate deaminase activity
CEW88_RS18085	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
CEW88_RS18090	COG0673	inositol 2-dehydrogenase activity
CEW88_RS18110	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CEW88_RS18145	COG1960	acyl-CoA dehydrogenase activity
CEW88_RS18150	COG0009	L-threonylcarbamoyladenylate synthase
CEW88_RS18155	COG1678	Uncharacterized ACR, COG1678
CEW88_RS18175	COG0521	Mo-molybdopterin cofactor biosynthetic process
CEW88_RS18185	COG1573	uracil-dna glycosylase
CEW88_RS18195	COG0803	Belongs to the bacterial solute-binding protein 9 family
CEW88_RS18200	COG1121	(ABC) transporter
CEW88_RS18205	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CEW88_RS18210	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CEW88_RS18215	COG1063	alcohol dehydrogenase
CEW88_RS18225	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CEW88_RS18230	COG0601	transmembrane transport
CEW88_RS18235	COG4166	transmembrane transport
CEW88_RS18240	COG1250	3-hydroxyacyl-CoA dehydrogenase
CEW88_RS18240	COG0824	Thioesterase
CEW88_RS18245	COG3246	L-lysine catabolic process to acetate
CEW88_RS18255	COG0657	acetylesterase activity
CEW88_RS18265	COG0306	phosphate transporter
CEW88_RS18280	COG1802	Transcriptional regulator
CEW88_RS18315	COG3246	L-lysine catabolic process to acetate
CEW88_RS18320	COG1028	Short-chain dehydrogenase reductase Sdr
CEW88_RS18325	COG1250	3-hydroxyacyl-CoA dehydrogenase
CEW88_RS18330	COG1011	Hydrolase
CEW88_RS18340	COG3639	organic phosphonate transmembrane transporter activity
CEW88_RS18385	COG1070	Carbohydrate kinase
CEW88_RS18395	COG1172	Belongs to the binding-protein-dependent transport system permease family
CEW88_RS18400	COG1129	ABC transporter
CEW88_RS18405	COG0673	inositol 2-dehydrogenase activity
CEW88_RS18420	COG1609	Transcriptional regulator
CEW88_RS18425	COG1653	transport
CEW88_RS18435	COG0395	ABC-type sugar transport system, permease component
CEW88_RS18440	COG3507	Belongs to the glycosyl hydrolase 43 family
CEW88_RS18450	COG0673	inositol 2-dehydrogenase activity
CEW88_RS18530	COG0154	amidase activity
CEW88_RS18535	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CEW88_RS18545	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CEW88_RS18550	COG0601	transmembrane transport
CEW88_RS18555	COG0747	negative chemotaxis
CEW88_RS18560	COG0235	Class ii aldolase
CEW88_RS18575	COG0789	Transcriptional regulator
CEW88_RS18600	COG0662	Cupin 2, conserved barrel domain protein
CEW88_RS18680	COG0662	Cupin 2, conserved barrel domain protein
CEW88_RS18680	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
CEW88_RS18725	COG1971	Probably functions as a manganese efflux pump
CEW88_RS18735	COG3436	PFAM IS66 Orf2 family protein
CEW88_RS18755	COG0583	DNA-binding transcription factor activity
CEW88_RS18770	COG4948	Mandelate Racemase Muconate Lactonizing
CEW88_RS18795	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CEW88_RS18800	COG0477	Major facilitator Superfamily
CEW88_RS18805	COG1959	2 iron, 2 sulfur cluster binding
CEW88_RS18810	COG3119	arylsulfatase activity
CEW88_RS18855	COG0444	Belongs to the ABC transporter superfamily
CEW88_RS18860	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CEW88_RS18870	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CEW88_RS18890	COG0583	DNA-binding transcription factor activity
CEW88_RS18895	COG0747	negative chemotaxis
CEW88_RS18900	COG0210	DNA helicase
CEW88_RS18915	COG0420	3'-5' exonuclease activity
CEW88_RS18925	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
CEW88_RS18945	COG1028	Short-chain dehydrogenase reductase Sdr
CEW88_RS18950	COG1733	regulation of RNA biosynthetic process
CEW88_RS19025	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CEW88_RS19115	COG1414	Transcriptional regulator
CEW88_RS19140	COG1506	peptidase
CEW88_RS19145	COG0747	negative chemotaxis
CEW88_RS19170	COG0444	Belongs to the ABC transporter superfamily
CEW88_RS19175	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CEW88_RS19180	COG0601	transmembrane transport
CEW88_RS19185	COG1172	Belongs to the binding-protein-dependent transport system permease family
CEW88_RS19200	COG1063	alcohol dehydrogenase
CEW88_RS19250	COG0601	transmembrane transport
CEW88_RS19255	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CEW88_RS19260	COG0445	tRNA wobble uridine modification
CEW88_RS19270	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CEW88_RS19285	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CEW88_RS19295	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CEW88_RS19305	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CEW88_RS19315	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CEW88_RS19320	COG1522	sequence-specific DNA binding
CEW88_RS19325	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CEW88_RS19330	COG0473	3-isopropylmalate dehydrogenase activity
CEW88_RS19335	COG1012	belongs to the aldehyde dehydrogenase family
CEW88_RS19345	COG1802	Transcriptional regulator
CEW88_RS19350	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CEW88_RS19360	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CEW88_RS19360	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CEW88_RS19365	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CEW88_RS19365	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CEW88_RS19370	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CEW88_RS19380	COG4154	Belongs to the RbsD FucU family
CEW88_RS19395	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CEW88_RS19400	COG0667	Aldo Keto reductase
CEW88_RS19410	COG2376	Dihydroxyacetone kinase
CEW88_RS19420	COG1129	ABC transporter
CEW88_RS19435	COG1609	Transcriptional regulator
CEW88_RS19440	COG1609	Transcriptional regulator
CEW88_RS19465	COG0673	inositol 2-dehydrogenase activity
CEW88_RS19480	COG2186	Transcriptional regulator
CEW88_RS19490	COG1566	PFAM secretion protein HlyD family protein
CEW88_RS19495	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CEW88_RS19500	COG0745	RESPONSE REGULATOR receiver
CEW88_RS19505	COG2205	protein histidine kinase activity
CEW88_RS19510	COG1132	(ABC) transporter
CEW88_RS19520	COG1053	succinate dehydrogenase
CEW88_RS19525	COG1802	Transcriptional regulator
CEW88_RS19535	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CEW88_RS19545	COG2828	Protein conserved in bacteria
CEW88_RS19565	COG2205	protein histidine kinase activity
CEW88_RS19585	COG0583	DNA-binding transcription factor activity
CEW88_RS19590	COG2433	Pfam Transposase IS66
CEW88_RS19615	COG1271	oxidase subunit
CEW88_RS19620	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CEW88_RS19625	COG0156	8-amino-7-oxononanoate synthase activity
CEW88_RS19630	COG0156	8-amino-7-oxononanoate synthase activity
CEW88_RS19640	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CEW88_RS19665	COG2144	transferase activity, transferring acyl groups
CEW88_RS19675	COG2072	flavoprotein involved in K transport
CEW88_RS19690	COG0583	DNA-binding transcription factor activity
CEW88_RS19695	COG0346	lactoylglutathione lyase activity
CEW88_RS19700	COG0400	carboxylic ester hydrolase activity
CEW88_RS19705	COG2388	GCN5-related N-acetyl-transferase
CEW88_RS19710	COG1741	Belongs to the pirin family
CEW88_RS19715	COG2205	protein histidine kinase activity
CEW88_RS19730	COG2223	nitrite transmembrane transporter activity
CEW88_RS19750	COG1215	transferase activity, transferring glycosyl groups
CEW88_RS19785	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CEW88_RS19790	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CEW88_RS19805	COG0356	it plays a direct role in the translocation of protons across the membrane
CEW88_RS19815	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CEW88_RS19815	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CEW88_RS19845	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
CEW88_RS19875	COG1446	asparaginase
CEW88_RS19890	COG0747	negative chemotaxis
CEW88_RS19910	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CEW88_RS19915	COG0601	transmembrane transport
CEW88_RS19920	COG2197	response regulator
CEW88_RS19940	COG2197	response regulator
CEW88_RS19945	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CEW88_RS19960	COG1215	transferase activity, transferring glycosyl groups
CEW88_RS19965	COG1216	Glycosyl transferase, family 2
CEW88_RS19970	COG0438	transferase activity, transferring glycosyl groups
CEW88_RS19980	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CEW88_RS20010	COG3038	cytochrome b561
CEW88_RS20015	COG0583	DNA-binding transcription factor activity
CEW88_RS20020	COG2080	2 iron, 2 sulfur cluster binding
CEW88_RS20025	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CEW88_RS20040	COG0402	S-adenosylhomocysteine deaminase activity
CEW88_RS20045	COG3257	ureidoglycine aminohydrolase activity
CEW88_RS20050	COG1414	Transcriptional regulator
CEW88_RS20055	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CEW88_RS20060	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CEW88_RS20065	COG3616	Alanine racemase, N-terminal domain
CEW88_RS20070	COG2423	ornithine cyclodeaminase activity
CEW88_RS20080	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
CEW88_RS20090	COG0583	DNA-binding transcription factor activity
CEW88_RS20100	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CEW88_RS20115	COG0726	polysaccharide deacetylase
CEW88_RS20120	COG1028	Short-chain dehydrogenase reductase Sdr
CEW88_RS20140	COG0747	negative chemotaxis
CEW88_RS20145	COG0601	transmembrane transport
CEW88_RS20150	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CEW88_RS20155	COG0444	Belongs to the ABC transporter superfamily
CEW88_RS20160	COG4608	Belongs to the ABC transporter superfamily
CEW88_RS20165	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
CEW88_RS20175	COG1309	transcriptional regulator
CEW88_RS20185	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CEW88_RS20200	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CEW88_RS20210	COG0235	Class ii aldolase
CEW88_RS20215	COG0824	Thioesterase
CEW88_RS20215	COG1250	3-hydroxyacyl-CoA dehydrogenase
CEW88_RS20220	COG3246	L-lysine catabolic process to acetate
CEW88_RS20235	COG1960	acyl-CoA dehydrogenase activity
CEW88_RS20250	COG3347	Dehydrogenase
CEW88_RS20250	COG1028	Short-chain dehydrogenase reductase Sdr
CEW88_RS20265	COG1172	Belongs to the binding-protein-dependent transport system permease family
CEW88_RS20270	COG1129	ABC transporter
CEW88_RS20275	COG2390	Transcriptional regulator
CEW88_RS20290	COG1126	abc transporter atp-binding protein
CEW88_RS20305	COG0583	DNA-binding transcription factor activity
CEW88_RS20310	COG2814	Major facilitator Superfamily
CEW88_RS20315	COG2186	Transcriptional regulator
CEW88_RS20340	COG1028	Short-chain dehydrogenase reductase Sdr
CEW88_RS20345	COG1063	alcohol dehydrogenase
CEW88_RS20365	COG1733	regulation of RNA biosynthetic process
CEW88_RS20370	COG0402	S-adenosylhomocysteine deaminase activity
CEW88_RS20390	COG1902	pentaerythritol trinitrate reductase activity
CEW88_RS20390	COG0446	pyridine nucleotide-disulphide oxidoreductase
CEW88_RS20405	COG1733	regulation of RNA biosynthetic process
CEW88_RS20425	COG1131	(ABC) transporter
CEW88_RS20430	COG0842	Transport permease protein
CEW88_RS20435	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CEW88_RS20440	COG2233	PERMEase
CEW88_RS20455	COG1309	transcriptional regulator
CEW88_RS20460	COG2249	NAD(P)H dehydrogenase (quinone) activity
CEW88_RS20465	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CEW88_RS20480	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CEW88_RS20505	COG1132	(ABC) transporter
CEW88_RS20520	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CEW88_RS20540	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CEW88_RS20545	COG1338	Plays a role in the flagellum-specific transport system
CEW88_RS20550	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CEW88_RS20570	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CEW88_RS20585	COG1706	bacterial-type flagellum-dependent cell motility
CEW88_RS20615	COG4786	Flagellar basal body rod
CEW88_RS20620	COG4786	Flagellar basal body rod
CEW88_RS20630	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
CEW88_RS20650	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CEW88_RS20660	COG1360	Flagellar Motor Protein
CEW88_RS20685	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CEW88_RS20710	COG2936	dipeptidyl-peptidase activity
CEW88_RS20720	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CEW88_RS20725	COG0601	transmembrane transport
CEW88_RS20735	COG0583	DNA-binding transcription factor activity
CEW88_RS20740	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CEW88_RS20740	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CEW88_RS20750	COG0246	Mannitol dehydrogenase
CEW88_RS20755	COG1312	Catalyzes the dehydration of D-mannonate
CEW88_RS20760	COG1802	Transcriptional regulator
CEW88_RS20765	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CEW88_RS20775	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CEW88_RS20780	COG1063	alcohol dehydrogenase
CEW88_RS20790	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CEW88_RS20795	COG3485	protocatechuate 3,4-dioxygenase
CEW88_RS20800	COG3485	protocatechuate 3,4-dioxygenase
CEW88_RS20810	COG0596	Alpha beta hydrolase
CEW88_RS20815	COG0583	DNA-binding transcription factor activity
CEW88_RS20820	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CEW88_RS20830	COG0456	acetyltransferase
CEW88_RS20840	COG1917	Cupin 2, conserved barrel domain protein
CEW88_RS20845	COG0527	aspartate kinase activity
CEW88_RS20850	COG0019	diaminopimelate decarboxylase activity
CEW88_RS20865	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CEW88_RS20875	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CEW88_RS20880	COG1305	Transglutaminase-like
CEW88_RS20885	COG0025	NhaP-type Na H and K H
CEW88_RS20895	COG1192	Involved in chromosome partitioning
CEW88_RS20920	COG1815	bacterial-type flagellum-dependent cell motility
CEW88_RS20925	COG1558	bacterial-type flagellum-dependent cell motility
CEW88_RS20930	COG1677	Flagellar hook-basal body complex protein FliE
CEW88_RS20935	COG1987	bacterial-type flagellum assembly
CEW88_RS20945	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CEW88_RS20950	COG1684	flagellar biosynthetic protein fliR
CEW88_RS20955	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CEW88_RS20985	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
CEW88_RS20990	COG1178	ABC-type Fe3 transport system permease component
CEW88_RS20995	COG1840	ABC-type Fe3 transport system, periplasmic component
CEW88_RS21000	COG3842	ATPase activity
CEW88_RS21005	COG2351	hydroxyisourate hydrolase activity
CEW88_RS21030	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CEW88_RS21050	COG2204	response regulator
CEW88_RS21060	COG2864	formate dehydrogenase
CEW88_RS21065	COG0437	4 iron, 4 sulfur cluster binding
CEW88_RS21070	COG3383	formate dehydrogenase (NAD+) activity
CEW88_RS21070	COG0243	molybdopterin cofactor binding
CEW88_RS21105	COG0489	protein tyrosine kinase activity
CEW88_RS21120	COG3852	Histidine kinase
CEW88_RS21125	COG3383	formate dehydrogenase (NAD+) activity
CEW88_RS21135	COG0425	Belongs to the sulfur carrier protein TusA family
CEW88_RS21140	COG0303	'Molybdopterin
CEW88_RS21145	COG1763	Mo-molybdopterin cofactor biosynthetic process
CEW88_RS21150	COG0746	molybdenum cofactor guanylyltransferase activity
CEW88_RS21180	COG1012	belongs to the aldehyde dehydrogenase family
CEW88_RS21185	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CEW88_RS21190	COG3246	L-lysine catabolic process to acetate
CEW88_RS21195	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CEW88_RS21205	COG4993	Dehydrogenase
CEW88_RS21215	COG2205	protein histidine kinase activity
CEW88_RS21230	COG1175	transmembrane transport
CEW88_RS21235	COG0395	ABC-type sugar transport system, permease component
CEW88_RS21240	COG3842	ATPase activity
CEW88_RS21255	COG1012	belongs to the aldehyde dehydrogenase family
CEW88_RS21260	COG0583	DNA-binding transcription factor activity
CEW88_RS21270	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CEW88_RS21275	COG4208	sulfate ABC transporter
CEW88_RS21285	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
CEW88_RS21290	COG1959	2 iron, 2 sulfur cluster binding
CEW88_RS21295	COG1522	sequence-specific DNA binding
CEW88_RS21315	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CEW88_RS21330	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CEW88_RS21335	COG0243	molybdopterin cofactor binding
CEW88_RS21340	COG1271	oxidase subunit
CEW88_RS21345	COG1294	oxidase, subunit
CEW88_RS21355	COG0655	NAD(P)H dehydrogenase (quinone) activity
CEW88_RS21360	COG2010	Cytochrome c
CEW88_RS21360	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CEW88_RS21365	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CEW88_RS21405	COG2873	o-acetylhomoserine
CEW88_RS21430	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CEW88_RS21435	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CEW88_RS21440	COG0583	DNA-binding transcription factor activity
CEW88_RS21470	COG0633	Ferredoxin
CEW88_RS21490	COG1609	Transcriptional regulator
CEW88_RS21515	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CEW88_RS21520	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CEW88_RS21525	COG1522	sequence-specific DNA binding
CEW88_RS21530	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CEW88_RS21535	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
CEW88_RS21540	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CEW88_RS21560	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
CEW88_RS21610	COG2099	Precorrin-6x reductase
CEW88_RS21625	COG2875	Belongs to the precorrin methyltransferase family
CEW88_RS21630	COG1797	cobyrinic acid a,c-diamide synthase activity
CEW88_RS21655	COG1028	Short-chain dehydrogenase reductase Sdr
CEW88_RS21660	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CEW88_RS21660	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CEW88_RS21670	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CEW88_RS21700	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CEW88_RS21705	COG0765	amino acid transport
CEW88_RS21710	COG0765	amino acid transport
CEW88_RS21720	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
CEW88_RS21740	COG3938	Belongs to the proline racemase family
CEW88_RS21745	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CEW88_RS21750	COG3938	Belongs to the proline racemase family
CEW88_RS21815	COG1116	anion transmembrane transporter activity
CEW88_RS21875	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
CEW88_RS21935	COG3791	Glutathione-dependent formaldehyde-activating
CEW88_RS21945	COG1414	Transcriptional regulator
CEW88_RS21950	COG1475	DNA binding
CEW88_RS21955	COG1192	Involved in chromosome partitioning
CEW88_RS21960	COG0535	radical SAM domain protein
CEW88_RS21965	COG0535	radical SAM domain protein
CEW88_RS21970	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
CEW88_RS21975	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CEW88_RS21985	COG0745	RESPONSE REGULATOR receiver
CEW88_RS22005	COG1131	(ABC) transporter
CEW88_RS22015	COG0583	DNA-binding transcription factor activity
CEW88_RS22025	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CEW88_RS22030	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CEW88_RS22050	COG0484	heat shock protein binding
CEW88_RS22075	COG1473	amidohydrolase
CEW88_RS22115	COG1755	Isoprenylcysteine carboxyl methyltransferase
CEW88_RS22120	COG3424	synthase
CEW88_RS22125	COG4529	Protein conserved in bacteria
CEW88_RS22140	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CEW88_RS22145	COG1116	anion transmembrane transporter activity
CEW88_RS22165	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
CEW88_RS22180	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CEW88_RS22190	COG0625	glutathione transferase activity
CEW88_RS22210	COG1028	Short-chain dehydrogenase reductase Sdr
CEW88_RS22220	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CEW88_RS22230	COG1902	pentaerythritol trinitrate reductase activity
CEW88_RS22235	COG1028	Short-chain dehydrogenase reductase Sdr
CEW88_RS22245	COG0251	oxidation-reduction process
CEW88_RS22265	COG0179	Fumarylacetoacetate (FAA) hydrolase
CEW88_RS22275	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
CEW88_RS22285	COG1846	Transcriptional regulator
CEW88_RS22305	COG0747	negative chemotaxis
CEW88_RS22310	COG0601	transmembrane transport
CEW88_RS22315	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CEW88_RS22320	COG0444	Belongs to the ABC transporter superfamily
CEW88_RS22345	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CEW88_RS22360	COG0243	molybdopterin cofactor binding
CEW88_RS22365	COG0437	4 iron, 4 sulfur cluster binding
CEW88_RS22370	COG0348	domain, Protein
CEW88_RS22455	COG0489	protein tyrosine kinase activity
CEW88_RS22490	COG0392	lysyltransferase activity
CEW88_RS22490	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
CEW88_RS22500	COG0671	phosphoesterase, PA-phosphatase related
CEW88_RS22510	COG0477	Major facilitator Superfamily
CEW88_RS22515	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CEW88_RS22520	COG1116	anion transmembrane transporter activity
CEW88_RS22525	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CEW88_RS22530	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CEW88_RS22535	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CEW88_RS22545	COG2022	thiamine diphosphate biosynthetic process
CEW88_RS22560	COG0351	phosphomethylpyrimidine kinase
CEW88_RS22565	COG1522	sequence-specific DNA binding
CEW88_RS22570	COG3483	tryptophan 2,3-dioxygenase activity
CEW88_RS22575	COG1126	abc transporter atp-binding protein
CEW88_RS22585	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CEW88_RS22590	COG0765	amino acid transport
CEW88_RS22595	COG3844	kynureninase activity
CEW88_RS22600	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CEW88_RS22605	COG1126	abc transporter atp-binding protein
CEW88_RS22610	COG0765	amino acid transport
CEW88_RS22635	COG2826	transposase and inactivated derivatives, IS30 family
CEW88_RS22645	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CEW88_RS22650	COG2186	Transcriptional regulator
CEW88_RS22655	COG0747	negative chemotaxis
CEW88_RS22660	COG0601	transmembrane transport
CEW88_RS22665	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CEW88_RS22670	COG0402	S-adenosylhomocysteine deaminase activity
CEW88_RS22675	COG0402	S-adenosylhomocysteine deaminase activity
CEW88_RS22680	COG0444	Belongs to the ABC transporter superfamily
CEW88_RS22685	COG4608	Belongs to the ABC transporter superfamily
CEW88_RS22690	COG0590	tRNA wobble adenosine to inosine editing
CEW88_RS22715	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CEW88_RS22735	COG0583	DNA-binding transcription factor activity
CEW88_RS22740	COG1053	succinate dehydrogenase
CEW88_RS22755	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CEW88_RS22760	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CEW88_RS22765	COG1028	Short-chain dehydrogenase reductase Sdr
CEW88_RS22770	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CEW88_RS22795	COG1024	Enoyl-CoA hydratase
CEW88_RS22795	COG1250	3-hydroxyacyl-CoA dehydrogenase
CEW88_RS22830	COG1024	Enoyl-CoA hydratase
CEW88_RS22835	COG2050	protein possibly involved in aromatic compounds catabolism
CEW88_RS22845	COG1309	transcriptional regulator
CEW88_RS22855	COG2030	dehydratase
CEW88_RS22855	COG1012	belongs to the aldehyde dehydrogenase family
CEW88_RS22865	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CEW88_RS22870	COG2151	metal-sulfur cluster biosynthetic enzyme
CEW88_RS22875	COG3396	Phenylacetate-CoA oxygenase
CEW88_RS22880	COG3460	Phenylacetate-CoA oxygenase
CEW88_RS22885	COG3396	Phenylacetate-CoA oxygenase
CEW88_RS22890	COG0183	Belongs to the thiolase family
CEW88_RS22895	COG3327	negative regulation of DNA-templated transcription, initiation
CEW88_RS22905	COG1522	sequence-specific DNA binding
CEW88_RS22920	COG0569	domain protein
CEW88_RS22925	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CEW88_RS22930	COG3842	ATPase activity
CEW88_RS22935	COG0395	ABC-type sugar transport system, permease component
CEW88_RS22940	COG1175	transmembrane transport
CEW88_RS22945	COG2182	Extracellular solute-binding protein
CEW88_RS22960	COG1609	Transcriptional regulator
CEW88_RS22965	COG1172	Belongs to the binding-protein-dependent transport system permease family
CEW88_RS22970	COG1129	ABC transporter
CEW88_RS23005	COG0583	DNA-binding transcription factor activity
CEW88_RS23020	COG3842	ATPase activity
CEW88_RS23030	COG0395	ABC-type sugar transport system, permease component
CEW88_RS23035	COG1175	transmembrane transport
CEW88_RS23045	COG1609	Transcriptional regulator
CEW88_RS23050	COG0625	glutathione transferase activity
CEW88_RS23060	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CEW88_RS23090	COG0667	Aldo Keto reductase
CEW88_RS23100	COG1802	Transcriptional regulator
CEW88_RS23115	COG0559	Belongs to the binding-protein-dependent transport system permease family
CEW88_RS23140	COG2067	long-chain fatty acid transport protein
CEW88_RS23145	COG0318	PFAM AMP-dependent synthetase and ligase
CEW88_RS23150	COG0789	Transcriptional regulator
CEW88_RS23155	COG0183	Belongs to the thiolase family
CEW88_RS23160	COG1250	3-hydroxyacyl-CoA dehydrogenase
CEW88_RS23160	COG1024	Enoyl-CoA hydratase
CEW88_RS23165	COG1960	acyl-CoA dehydrogenase activity
CEW88_RS23170	COG1028	Short-chain dehydrogenase reductase Sdr
CEW88_RS23185	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CEW88_RS23190	COG1126	abc transporter atp-binding protein
CEW88_RS23195	COG0765	amino acid transport
CEW88_RS23200	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CEW88_RS23205	COG2186	Transcriptional regulator
CEW88_RS23220	COG0640	Transcriptional regulator
CEW88_RS23225	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CEW88_RS23230	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CEW88_RS23245	COG1802	Transcriptional regulator
CEW88_RS23250	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CEW88_RS23270	COG1028	Short-chain dehydrogenase reductase Sdr
CEW88_RS23275	COG1024	Enoyl-CoA hydratase
CEW88_RS23280	COG0318	PFAM AMP-dependent synthetase and ligase
CEW88_RS23305	COG1366	Belongs to the anti-sigma-factor antagonist family
CEW88_RS23310	COG1366	Belongs to the anti-sigma-factor antagonist family
CEW88_RS23315	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CEW88_RS23320	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
CEW88_RS23325	COG2080	2 iron, 2 sulfur cluster binding
CEW88_RS23340	COG0640	Transcriptional regulator
CEW88_RS23355	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CEW88_RS23395	COG1028	Short-chain dehydrogenase reductase Sdr
CEW88_RS23405	COG0179	Fumarylacetoacetate (FAA) hydrolase
CEW88_RS23415	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CEW88_RS23420	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CEW88_RS23430	COG1028	Short-chain dehydrogenase reductase Sdr
CEW88_RS23435	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CEW88_RS23440	COG0471	metal ion transport
CEW88_RS23445	COG4948	Mandelate Racemase Muconate Lactonizing
CEW88_RS23455	COG0596	Alpha beta hydrolase
CEW88_RS23460	COG0583	DNA-binding transcription factor activity
CEW88_RS23480	COG3206	protein involved in exopolysaccharide biosynthesis
CEW88_RS23480	COG0489	protein tyrosine kinase activity
CEW88_RS23500	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CEW88_RS23520	COG1442	glycosyl transferase family 8
CEW88_RS23520	COG1216	Glycosyl transferase, family 2
CEW88_RS23540	COG0667	Aldo Keto reductase
CEW88_RS23550	COG0673	inositol 2-dehydrogenase activity
CEW88_RS23575	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CEW88_RS23585	COG0175	sulfate reduction
CEW88_RS23620	COG1192	Involved in chromosome partitioning
CEW88_RS23710	COG3562	capsule polysaccharide
CEW88_RS23750	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
CEW88_RS23755	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CEW88_RS23765	COG0517	IMP dehydrogenase activity
CEW88_RS23765	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CEW88_RS23770	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
CEW88_RS23775	COG2877	3-deoxy-8-phosphooctulonate synthase activity
CEW88_RS23855	COG2244	polysaccharide biosynthetic process
CEW88_RS23860	COG2327	Polysaccharide pyruvyl transferase
CEW88_RS23890	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CEW88_RS23905	COG1216	Glycosyl transferase, family 2
CEW88_RS23910	COG0463	Glycosyl transferase, family 2
CEW88_RS23915	COG0251	oxidation-reduction process
CEW88_RS23920	COG0747	negative chemotaxis
CEW88_RS23925	COG0601	transmembrane transport
CEW88_RS23930	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CEW88_RS23935	COG0444	Belongs to the ABC transporter superfamily
CEW88_RS23940	COG4608	Belongs to the ABC transporter superfamily
CEW88_RS23965	COG0765	amino acid transport
CEW88_RS23990	COG0210	DNA helicase
CEW88_RS23995	COG0318	PFAM AMP-dependent synthetase and ligase
CEW88_RS24000	COG0183	Belongs to the thiolase family
CEW88_RS24010	COG1268	BioY protein
CEW88_RS24015	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CEW88_RS24020	COG1122	ATPase activity
CEW88_RS24035	COG2124	cytochrome p450
CEW88_RS24035	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CEW88_RS24090	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CEW88_RS24110	COG0402	S-adenosylhomocysteine deaminase activity
CEW88_RS24130	COG1028	Short-chain dehydrogenase reductase Sdr
CEW88_RS24140	COG1268	BioY protein
CEW88_RS24145	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CEW88_RS24170	COG1278	Cold shock
CEW88_RS24245	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CEW88_RS24275	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CEW88_RS24295	COG1652	LysM domain
CEW88_RS24300	COG2954	triphosphatase activity
CEW88_RS24315	COG0657	acetylesterase activity
CEW88_RS24320	COG3104	oligopeptide transport
CEW88_RS24330	COG1192	Involved in chromosome partitioning
CEW88_RS24350	COG2814	Major facilitator Superfamily
CEW88_RS24370	COG0110	maltose O-acetyltransferase activity