locus-tag	class	description
CH48_RS00030	COG0416	fatty acid biosynthetic process
CH48_RS00080	COG1530	ribonuclease E activity
CH48_RS00185	COG1560	Kdo2-lipid A biosynthetic process
CH48_RS00455	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CH48_RS00460	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CH48_RS00470	COG1028	Short-chain dehydrogenase reductase Sdr
CH48_RS00475	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CH48_RS00480	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CH48_RS00485	COG0416	fatty acid biosynthetic process
CH48_RS00490	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CH48_RS00495	COG1399	metal-binding, possibly nucleic acid-binding protein
CH48_RS00500	COG0424	maF-like protein
CH48_RS00505	COG0564	pseudouridine synthase activity
CH48_RS00510	COG1530	ribonuclease E activity
CH48_RS00515	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
CH48_RS00520	COG0418	dihydroorotase activity
CH48_RS00545	COG0628	permease
CH48_RS00550	COG1054	Belongs to the UPF0176 family
CH48_RS00585	COG1560	Kdo2-lipid A biosynthetic process
CH48_RS00600	COG2259	Doxx family
CH48_RS00630	COG5645	(Lipo)protein
CH48_RS00635	COG2943	transferase activity, transferring hexosyl groups
CH48_RS00640	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
CH48_RS00660	COG3263	regulation of cellular component size
CH48_RS00670	COG3916	Acyl-homoserine-lactone synthase
CH48_RS00675	COG2771	luxR family
CH48_RS00680	COG4235	cytochrome complex assembly
CH48_RS00685	COG3088	subunit of a heme lyase
CH48_RS00690	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CH48_RS00695	COG1138	Cytochrome C-type biogenesis protein
CH48_RS00700	COG3301	Polysulphide reductase, NrfD
CH48_RS00705	COG0437	4 iron, 4 sulfur cluster binding
CH48_RS00710	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
CH48_RS00725	COG2920	part of a sulfur-relay system
CH48_RS00730	COG1254	Belongs to the acylphosphatase family
CH48_RS00745	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CH48_RS00750	COG3785	DNA binding
CH48_RS00755	COG1832	CoA-binding protein
CH48_RS00765	COG1803	Methylglyoxal synthase
CH48_RS00770	COG0210	DNA helicase
CH48_RS00775	COG3304	Inner membrane component domain
CH48_RS00780	COG1289	transmembrane transporter activity
CH48_RS00785	COG3070	regulator of competence-specific genes
CH48_RS00790	COG5404	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
CH48_RS00800	COG3120	sequence-specific DNA binding
CH48_RS00805	COG1067	ATP-dependent peptidase activity
CH48_RS00810	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CH48_RS00825	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CH48_RS00830	COG3009	Protein conserved in bacteria
CH48_RS00835	COG3008	intermembrane lipid transfer
CH48_RS00835	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CH48_RS00840	COG2995	paraquat-inducible protein a
CH48_RS00845	COG0488	(ABC) transporter
CH48_RS00850	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CH48_RS00850	COG0116	Belongs to the methyltransferase superfamily
CH48_RS00855	COG0633	Ferredoxin
CH48_RS00855	COG3217	Mosc domain protein beta barrel domain protein
CH48_RS00865	COG0167	dihydroorotate dehydrogenase activity
CH48_RS00870	COG0308	aminopeptidase N
CH48_RS00875	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CH48_RS00880	COG0017	Asparaginyl-tRNA synthetase
CH48_RS00890	COG1448	Aminotransferase
CH48_RS00900	COG2200	EAL domain
CH48_RS00905	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CH48_RS00910	COG3108	Peptidase M15
CH48_RS00915	COG2989	Protein conserved in bacteria
CH48_RS00920	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
CH48_RS00930	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
CH48_RS00935	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CH48_RS00940	COG1434	Gram-negative-bacterium-type cell wall biogenesis
CH48_RS00945	COG3173	Aminoglycoside phosphotransferase
CH48_RS00950	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
CH48_RS00955	COG2835	tetraacyldisaccharide 4'-kinase activity
CH48_RS00960	COG1278	Cold shock
CH48_RS00970	COG5383	Protein conserved in bacteria
CH48_RS00975	COG1663	tetraacyldisaccharide 4'-kinase activity
CH48_RS00985	COG2333	competence protein COMEC
CH48_RS00985	COG0658	competence protein
CH48_RS00990	COG0776	regulation of translation
CH48_RS00995	COG0539	negative regulation of cytoplasmic translation
CH48_RS01000	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CH48_RS01005	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CH48_RS01010	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CH48_RS01015	COG2323	membrane
CH48_RS01020	COG0252	asparaginase activity
CH48_RS01025	COG1944	ATP diphosphatase activity
CH48_RS01030	COG2116	formate transmembrane transporter activity
CH48_RS01035	COG1882	Formate acetyltransferase
CH48_RS01040	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CH48_RS01045	COG2814	Major facilitator Superfamily
CH48_RS01055	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CH48_RS01060	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CH48_RS01065	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
CH48_RS01070	COG3107	peptidoglycan biosynthetic process
CH48_RS01070	COG1674	ftsk spoiiie
CH48_RS01075	COG1522	sequence-specific DNA binding
CH48_RS01080	COG0492	ferredoxin-NADP+ reductase activity
CH48_RS01090	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
CH48_RS01095	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
CH48_RS01100	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CH48_RS01105	COG0542	response to heat
CH48_RS01110	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CH48_RS01120	COG1278	Cold shock
CH48_RS01130	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CH48_RS01135	COG2990	Protein conserved in bacteria
CH48_RS01140	COG3593	DNA synthesis involved in DNA repair
CH48_RS01145	COG2431	L-lysine efflux transmembrane transporter activity
CH48_RS01150	COG1151	hydroxylamine reductase activity
CH48_RS01155	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CH48_RS01160	COG0028	Belongs to the TPP enzyme family
CH48_RS01170	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
CH48_RS01175	COG0702	epimerase
CH48_RS01180	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CH48_RS01190	COG1126	abc transporter atp-binding protein
CH48_RS01195	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CH48_RS01200	COG4215	(ABC) transporter
CH48_RS01205	COG4160	amino acid transport
CH48_RS01210	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CH48_RS01215	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CH48_RS01225	COG1177	transmembrane transport
CH48_RS01230	COG1176	ABC-type spermidine putrescine transport system, permease component I
CH48_RS01235	COG3842	ATPase activity
CH48_RS01240	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CH48_RS01260	COG0569	domain protein
CH48_RS01260	COG2985	domain, Protein
CH48_RS01270	COG0671	phosphoesterase, PA-phosphatase related
CH48_RS01275	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CH48_RS01280	COG1349	DNA-binding transcription factor activity
CH48_RS01285	COG0814	amino acid
CH48_RS01290	COG1760	l-serine dehydratase
CH48_RS01300	COG1686	Belongs to the peptidase S11 family
CH48_RS01310	COG0626	cystathionine gamma-synthase activity
CH48_RS01315	COG2011	ABC-type metal ion transport system permease component
CH48_RS01340	COG0625	glutathione transferase activity
CH48_RS01345	COG4771	TonB-dependent receptor
CH48_RS01355	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CH48_RS01360	COG0833	amino acid
CH48_RS01365	COG0583	DNA-binding transcription factor activity
CH48_RS01380	COG2855	membrane
CH48_RS01385	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
CH48_RS01410	COG3710	Transcriptional regulator
CH48_RS01415	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CH48_RS01415	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CH48_RS01415	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
CH48_RS01420	COG1105	Belongs to the carbohydrate kinase PfkB family
CH48_RS01435	COG3005	denitrification pathway
CH48_RS01440	COG0243	molybdopterin cofactor binding
CH48_RS01455	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CH48_RS01460	COG1312	Catalyzes the dehydration of D-mannonate
CH48_RS01470	COG0246	Mannitol dehydrogenase
CH48_RS01475	COG2186	Transcriptional regulator
CH48_RS01485	COG0523	cobalamin synthesis protein
CH48_RS01490	COG0671	phosphoesterase, PA-phosphatase related
CH48_RS01495	COG0791	NLP P60 protein
CH48_RS01505	COG2200	EAL domain
CH48_RS01510	COG4166	transmembrane transport
CH48_RS01515	COG4174	ABC transporter (Permease)
CH48_RS01520	COG4239	(ABC) transporter, permease
CH48_RS01525	COG4172	Belongs to the ABC transporter superfamily
CH48_RS01535	COG2814	Major facilitator Superfamily
CH48_RS01540	COG1187	pseudouridine synthase activity
CH48_RS01545	COG1061	Type III restriction enzyme res subunit
CH48_RS01550	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CH48_RS01555	COG3081	Nucleoid-associated protein
CH48_RS01560	COG3082	Protein of unknown function (DUF1414)
CH48_RS01585	COG3328	transposase activity
CH48_RS01600	COG2801	Transposase and inactivated derivatives
CH48_RS01620	COG2723	6-phospho-beta-galactosidase activity
CH48_RS01625	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CH48_RS01625	COG2190	(PTS) system
CH48_RS01625	COG1263	PTS System
CH48_RS01630	COG1737	Transcriptional regulator
CH48_RS01685	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CH48_RS01700	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CH48_RS01720	COG2223	nitrite transmembrane transporter activity
CH48_RS01725	COG2198	Histidine kinase
CH48_RS01725	COG0642	Histidine kinase
CH48_RS01730	COG2197	response regulator
CH48_RS01735	COG0784	Response regulator, receiver
CH48_RS01735	COG2205	protein histidine kinase activity
CH48_RS01750	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CH48_RS01755	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CH48_RS01765	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CH48_RS01770	COG4574	serine-type endopeptidase inhibitor activity
CH48_RS01795	COG0814	amino acid
CH48_RS01815	COG1441	menaquinone biosynthetic process
CH48_RS01820	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CH48_RS01825	COG0596	Alpha beta hydrolase
CH48_RS01830	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
CH48_RS01835	COG1169	isochorismate synthase
CH48_RS01840	COG3328	transposase activity
CH48_RS01845	COG4575	ribosome binding
CH48_RS01855	COG4702	Belongs to the UPF0303 family
CH48_RS01865	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CH48_RS01875	COG1028	Short-chain dehydrogenase reductase Sdr
CH48_RS01880	COG3265	gluconokinase activity
CH48_RS01900	COG1007	ATP synthesis coupled electron transport
CH48_RS01905	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CH48_RS01910	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CH48_RS01915	COG0713	ATP synthesis coupled electron transport
CH48_RS01920	COG0839	Belongs to the complex I subunit 6 family
CH48_RS01925	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CH48_RS01930	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CH48_RS01935	COG1034	ATP synthesis coupled electron transport
CH48_RS01950	COG0649	NAD binding
CH48_RS01950	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CH48_RS01955	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CH48_RS01960	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CH48_RS01965	COG0583	DNA-binding transcription factor activity
CH48_RS01970	COG0436	Aminotransferase
CH48_RS01975	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
CH48_RS01980	COG0490	domain, Protein
CH48_RS01980	COG0471	metal ion transport
CH48_RS01990	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CH48_RS01995	COG3013	Belongs to the UPF0304 family
CH48_RS02000	COG3092	negative regulation of chromosome organization
CH48_RS02010	COG0280	phosphate acetyltransferase
CH48_RS02010	COG0857	belongs to the CobB CobQ family
CH48_RS02015	COG1609	Transcriptional regulator
CH48_RS02020	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH48_RS02030	COG3037	sugar-specific permease SgaT UlaA
CH48_RS02045	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
CH48_RS02050	COG0622	Phosphoesterase
CH48_RS02060	COG1090	epimerase
CH48_RS02070	COG4598	ABC transporter
CH48_RS02075	COG4160	amino acid transport
CH48_RS02080	COG4215	(ABC) transporter
CH48_RS02085	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CH48_RS02090	COG0163	prenyltransferase activity
CH48_RS02095	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CH48_RS02100	COG1286	toxin biosynthetic process
CH48_RS02105	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
CH48_RS02110	COG0285	dihydrofolate synthase activity
CH48_RS02115	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CH48_RS02120	COG0586	Pfam SNARE associated Golgi protein
CH48_RS02130	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CH48_RS02150	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CH48_RS02160	COG0697	spore germination
CH48_RS02165	COG0697	spore germination
CH48_RS02170	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CH48_RS02175	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CH48_RS02200	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CH48_RS02210	COG1609	Transcriptional regulator
CH48_RS02220	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CH48_RS02225	COG2723	6-phospho-beta-galactosidase activity
CH48_RS02230	COG1447	Phosphotransferase system cellobiose-specific component IIA
CH48_RS02240	COG1794	racemase activity, acting on amino acids and derivatives
CH48_RS02245	COG3706	GGDEF domain
CH48_RS02250	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CH48_RS02255	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
CH48_RS02255	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CH48_RS02265	COG3101	peptidyl-lysine hydroxylation
CH48_RS02270	COG0730	response to heat
CH48_RS02275	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
CH48_RS02280	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CH48_RS02285	COG2890	protein-(glutamine-N5) methyltransferase activity
CH48_RS02290	COG2840	Smr protein MutS2
CH48_RS02295	COG2062	phosphohistidine phosphatase, SixA
CH48_RS02300	COG1250	3-hydroxyacyl-CoA dehydrogenase
CH48_RS02300	COG1024	Enoyl-CoA hydratase
CH48_RS02305	COG0183	Belongs to the thiolase family
CH48_RS02310	COG3691	Protein conserved in bacteria
CH48_RS02325	COG4235	cytochrome complex assembly
CH48_RS02325	COG3088	subunit of a heme lyase
CH48_RS02335	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CH48_RS02340	COG1138	Cytochrome C-type biogenesis protein
CH48_RS02345	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
CH48_RS02350	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CH48_RS02355	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CH48_RS02360	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CH48_RS02375	COG0837	glucose binding
CH48_RS02390	COG3961	Belongs to the TPP enzyme family
CH48_RS02395	COG0667	Aldo Keto reductase
CH48_RS02405	COG1914	H( )-stimulated, divalent metal cation uptake system
CH48_RS02410	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CH48_RS02435	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CH48_RS02465	COG3530	Putative quorum-sensing-regulated virulence factor
CH48_RS02470	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CH48_RS02490	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH48_RS02495	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CH48_RS02505	COG2205	protein histidine kinase activity
CH48_RS02510	COG0745	RESPONSE REGULATOR receiver
CH48_RS02515	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CH48_RS02535	COG4208	sulfate ABC transporter
CH48_RS02540	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
CH48_RS02545	COG4150	thiosulfate binding
CH48_RS02555	COG1737	Transcriptional regulator
CH48_RS02560	COG2731	YhcH YjgK YiaL family protein
CH48_RS02575	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CH48_RS02585	COG2837	iron assimilation
CH48_RS02595	COG3111	PFAM Bacterial OB fold (BOF) protein
CH48_RS02600	COG0456	acetyltransferase
CH48_RS02605	COG0408	coproporphyrinogen oxidase activity
CH48_RS02610	COG1671	Belongs to the UPF0178 family
CH48_RS02630	COG0281	malic enzyme
CH48_RS02630	COG0280	phosphate acetyltransferase
CH48_RS02635	COG0494	nUDIX hydrolase
CH48_RS02640	COG3005	denitrification pathway
CH48_RS02645	COG3043	anaerobic respiration
CH48_RS02650	COG0243	molybdopterin cofactor binding
CH48_RS02655	COG3062	negative regulation of establishment of protein localization
CH48_RS02665	COG2197	response regulator
CH48_RS02675	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CH48_RS02690	COG1393	Belongs to the ArsC family
CH48_RS02695	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CH48_RS02700	COG1876	peptidase activity
CH48_RS02745	COG0400	carboxylic ester hydrolase activity
CH48_RS02760	COG1444	tRNA N-acetyltransferase activity
CH48_RS02765	COG2707	UPF0756 membrane protein
CH48_RS02770	COG2321	neutral zinc metallopeptidase
CH48_RS02775	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CH48_RS02780	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
CH48_RS02785	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CH48_RS02790	COG2716	regulation of RNA biosynthetic process
CH48_RS02795	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CH48_RS02800	COG0628	permease
CH48_RS02805	COG4783	chaperone-mediated protein folding
CH48_RS02810	COG1393	Belongs to the ArsC family
CH48_RS02815	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CH48_RS02820	COG2233	PERMEase
CH48_RS02825	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CH48_RS02830	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CH48_RS02835	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CH48_RS02840	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CH48_RS02855	COG0581	inorganic phosphate transmembrane transporter activity
CH48_RS02860	COG0573	inorganic phosphate transmembrane transporter activity
CH48_RS02865	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CH48_RS02880	COG2239	Acts as a magnesium transporter
CH48_RS02885	COG5002	protein histidine kinase activity
CH48_RS02885	COG3447	MASE1 domain protein
CH48_RS02885	COG5001	Diguanylate cyclase
CH48_RS02890	COG0443	Heat shock 70 kDa protein
CH48_RS02895	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CH48_RS02905	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CH48_RS02910	COG0477	Major facilitator Superfamily
CH48_RS02915	COG2205	protein histidine kinase activity
CH48_RS02920	COG0745	RESPONSE REGULATOR receiver
CH48_RS02925	COG3422	double-strand break repair
CH48_RS02930	COG0826	peptidase U32
CH48_RS02935	COG1597	lipid kinase activity
CH48_RS02940	COG3730	PTS system glucitol sorbitol-specific
CH48_RS02955	COG1028	Short-chain dehydrogenase reductase Sdr
CH48_RS02960	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH48_RS02965	COG1349	DNA-binding transcription factor activity
CH48_RS02985	COG0351	phosphomethylpyrimidine kinase
CH48_RS03020	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CH48_RS03020	COG0519	Catalyzes the synthesis of GMP from XMP
CH48_RS03025	COG0516	GMP reductase activity
CH48_RS03025	COG0517	IMP dehydrogenase activity
CH48_RS03030	COG1570	exodeoxyribonuclease VII activity
CH48_RS03035	COG1645	bacterial-type flagellum-dependent swarming motility
CH48_RS03050	COG1160	GTP binding
CH48_RS03060	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CH48_RS03065	COG2976	Protein conserved in bacteria
CH48_RS03070	COG0124	histidyl-tRNA synthetase
CH48_RS03075	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CH48_RS03080	COG1426	Protein conserved in bacteria
CH48_RS03090	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CH48_RS03105	COG4953	penicillin-binding protein 1C
CH48_RS03110	COG2373	Large extracellular alpha-helical protein
CH48_RS03115	COG3468	outer membrane autotransporter barrel domain protein
CH48_RS03130	COG2975	iron-sulfur cluster assembly
CH48_RS03135	COG0633	Ferredoxin
CH48_RS03140	COG0443	Heat shock 70 kDa protein
CH48_RS03145	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CH48_RS03150	COG0316	Belongs to the HesB IscA family
CH48_RS03155	COG0822	iron-sulfur transferase activity
CH48_RS03165	COG1959	2 iron, 2 sulfur cluster binding
CH48_RS03170	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
CH48_RS03180	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
CH48_RS03185	COG3683	transport system, periplasmic component
CH48_RS03190	COG3711	transcriptional antiterminator
CH48_RS03195	COG2814	Major facilitator Superfamily
CH48_RS03200	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CH48_RS03205	COG1017	nitric oxide dioxygenase activity
CH48_RS03205	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CH48_RS03210	COG2188	Transcriptional regulator
CH48_RS03215	COG2188	Transcriptional regulator
CH48_RS03225	COG3457	Alanine racemase
CH48_RS03230	COG1735	metal-dependent hydrolase with the TIM-barrel fold
CH48_RS03245	COG0347	Belongs to the P(II) protein family
CH48_RS03250	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CH48_RS03250	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CH48_RS03255	COG2204	response regulator
CH48_RS03260	COG3170	Tfp pilus assembly protein FimV
CH48_RS03265	COG2205	protein histidine kinase activity
CH48_RS03280	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
CH48_RS03295	COG0560	Phosphoserine phosphatase
CH48_RS03305	COG1737	Transcriptional regulator
CH48_RS03310	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CH48_RS03315	COG2610	gluconate transmembrane transporter activity
CH48_RS03320	COG0736	holo-[acyl-carrier-protein] synthase activity
CH48_RS03325	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CH48_RS03330	COG1381	Involved in DNA repair and RecF pathway recombination
CH48_RS03335	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CH48_RS03340	COG0571	ribonuclease III activity
CH48_RS03350	COG0481	GTPase activity
CH48_RS03360	COG3086	response to oxidative stress
CH48_RS03370	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
CH48_RS03380	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CH48_RS03385	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CH48_RS03390	COG0513	Belongs to the DEAD box helicase family
CH48_RS03420	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
CH48_RS03425	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CH48_RS03430	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CH48_RS03435	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CH48_RS03440	COG0497	DNA recombination
CH48_RS03445	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CH48_RS03455	COG2867	negative regulation of translational initiation
CH48_RS03460	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CH48_RS03465	COG0582	viral genome integration into host DNA
CH48_RS03505	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CH48_RS03525	COG3394	polysaccharide catabolic process
CH48_RS03530	COG1917	Cupin 2, conserved barrel domain protein
CH48_RS03530	COG2169	Transcriptional regulator
CH48_RS03535	COG1447	Phosphotransferase system cellobiose-specific component IIA
CH48_RS03540	COG2723	6-phospho-beta-galactosidase activity
CH48_RS03545	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CH48_RS03550	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CH48_RS03555	COG2133	pyrroloquinoline quinone binding
CH48_RS03580	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CH48_RS03590	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
CH48_RS03595	COG4413	Urea transporter
CH48_RS03600	COG0829	nickel cation binding
CH48_RS03605	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CH48_RS03610	COG0830	nickel cation binding
CH48_RS03615	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
CH48_RS03620	COG0804	urea catabolic process
CH48_RS03625	COG0832	Belongs to the urease beta subunit family
CH48_RS03630	COG0831	urea catabolic process
CH48_RS03635	COG1124	(ABC) transporter
CH48_RS03645	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CH48_RS03685	COG1278	Cold shock
CH48_RS03710	COG2207	Transcriptional regulator
CH48_RS03730	COG4575	ribosome binding
CH48_RS03740	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CH48_RS03750	COG1780	Probably involved in ribonucleotide reductase function
CH48_RS03760	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CH48_RS03770	COG4176	ABC-type proline glycine betaine transport system permease component
CH48_RS03775	COG2113	Glycine betaine
CH48_RS03790	COG0328	RNA-DNA hybrid ribonuclease activity
CH48_RS03795	COG2226	methyltransferase
CH48_RS03800	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CH48_RS03805	COG1388	LysM domain
CH48_RS03805	COG0741	lytic transglycosylase activity
CH48_RS03815	COG3021	interspecies interaction between organisms
CH48_RS03820	COG2814	Major facilitator Superfamily
CH48_RS03825	COG0583	DNA-binding transcription factor activity
CH48_RS03830	COG0656	L-ascorbic acid biosynthetic process
CH48_RS03870	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CH48_RS03880	COG2011	ABC-type metal ion transport system permease component
CH48_RS03885	COG1464	Belongs to the NlpA lipoprotein family
CH48_RS03895	COG1720	tRNA m6t6A37 methyltransferase activity
CH48_RS03900	COG0442	prolyl-tRNA aminoacylation
CH48_RS03905	COG3015	lipoprotein NlpE involved in copper resistance
CH48_RS03915	COG4681	YaeQ
CH48_RS03925	COG4568	rho-dependent transcription termination
CH48_RS03940	COG0346	lactoylglutathione lyase activity
CH48_RS03945	COG1982	Orn Lys Arg decarboxylase major
CH48_RS03950	COG0825	malonyl-CoA metabolic process
CH48_RS03960	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CH48_RS03970	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CH48_RS03975	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CH48_RS03980	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CH48_RS03985	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
CH48_RS03995	COG0750	zinc metalloprotease
CH48_RS04000	COG0575	Belongs to the CDS family
CH48_RS04010	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CH48_RS04015	COG0233	cytoplasmic translational termination
CH48_RS04020	COG0528	UMP kinase activity
CH48_RS04025	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CH48_RS04030	COG0052	Belongs to the universal ribosomal protein uS2 family
CH48_RS04040	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
CH48_RS04045	COG2171	N-acyltransferase activity
CH48_RS04060	COG0564	pseudouridine synthase activity
CH48_RS04065	COG3098	single-species biofilm formation
CH48_RS04075	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CH48_RS04075	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CH48_RS04080	COG1611	Belongs to the LOG family
CH48_RS04085	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CH48_RS04095	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
CH48_RS04100	COG2363	Small membrane protein
CH48_RS04105	COG0583	DNA-binding transcription factor activity
CH48_RS04115	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CH48_RS04120	COG2166	iron-sulfur cluster assembly
CH48_RS04125	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CH48_RS04130	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
CH48_RS04150	COG0860	N-Acetylmuramoyl-L-alanine amidase
CH48_RS04155	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CH48_RS04155	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
CH48_RS04165	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CH48_RS04170	COG1074	ATP-dependent DNA helicase activity
CH48_RS04175	COG1025	Belongs to the peptidase M16 family
CH48_RS04180	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
CH48_RS04200	COG2165	general secretion pathway protein
CH48_RS04205	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CH48_RS04210	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CH48_RS04220	COG1051	belongs to the nudix hydrolase family
CH48_RS04230	COG3066	DNA modification
CH48_RS04235	COG0861	Integral membrane protein TerC family
CH48_RS04240	COG0667	Aldo Keto reductase
CH48_RS04245	COG0477	Major facilitator Superfamily
CH48_RS04250	COG0318	PFAM AMP-dependent synthetase and ligase
CH48_RS04250	COG0204	Acyl-transferase
CH48_RS04265	COG1609	Transcriptional regulator
CH48_RS04275	COG0583	DNA-binding transcription factor activity
CH48_RS04280	COG2814	Major facilitator Superfamily
CH48_RS04320	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CH48_RS04350	COG2165	general secretion pathway protein
CH48_RS04360	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CH48_RS04380	COG0288	reversible hydration of carbon dioxide
CH48_RS04385	COG1733	regulation of RNA biosynthetic process
CH48_RS04390	COG1028	Short-chain dehydrogenase reductase Sdr
CH48_RS04400	COG0484	heat shock protein binding
CH48_RS04410	COG3706	GGDEF domain
CH48_RS04415	COG4319	ketosteroid isomerase
CH48_RS04430	COG3328	transposase activity
CH48_RS04435	COG2944	sequence-specific DNA binding
CH48_RS04510	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CH48_RS04515	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CH48_RS04520	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CH48_RS04525	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CH48_RS04530	COG4974	Belongs to the 'phage' integrase family
CH48_RS04535	COG0716	FMN binding
CH48_RS04540	COG4452	Inner membrane protein CreD
CH48_RS04545	COG2205	protein histidine kinase activity
CH48_RS04550	COG0745	RESPONSE REGULATOR receiver
CH48_RS04565	COG0354	folic acid binding
CH48_RS04575	COG1272	protein, Hemolysin III
CH48_RS04585	COG1028	Short-chain dehydrogenase reductase Sdr
CH48_RS04595	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CH48_RS04595	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CH48_RS04600	COG0509	glycine decarboxylation via glycine cleavage system
CH48_RS04605	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CH48_RS04610	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CH48_RS04615	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CH48_RS04620	COG0006	proline dipeptidase activity
CH48_RS04625	COG3079	Belongs to the UPF0149 family
CH48_RS04630	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
CH48_RS04635	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CH48_RS04640	COG0148	phosphopyruvate hydratase activity
CH48_RS04645	COG0504	CTP synthase activity
CH48_RS04650	COG3956	TIGRFAM MazG family protein
CH48_RS04655	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CH48_RS04660	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CH48_RS04665	COG4999	Histidine kinase
CH48_RS04665	COG3850	Histidine kinase
CH48_RS04665	COG3437	response regulator, receiver
CH48_RS04665	COG2205	protein histidine kinase activity
CH48_RS04670	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CH48_RS04675	COG0232	Belongs to the dGTPase family. Type 2 subfamily
CH48_RS04680	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CH48_RS04690	COG2860	membrane
CH48_RS04695	COG0316	Belongs to the HesB IscA family
CH48_RS04705	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CH48_RS04710	COG2223	nitrite transmembrane transporter activity
CH48_RS04715	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CH48_RS04720	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CH48_RS04725	COG1120	ATPase activity
CH48_RS04730	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CH48_RS04735	COG1643	Atp-dependent helicase
CH48_RS04740	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
CH48_RS04745	COG1489	DNA binding
CH48_RS04765	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CH48_RS04770	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CH48_RS04775	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CH48_RS04780	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CH48_RS04785	COG0726	polysaccharide deacetylase
CH48_RS04790	COG0842	Transport permease protein
CH48_RS04795	COG1131	(ABC) transporter
CH48_RS04800	COG0288	reversible hydration of carbon dioxide
CH48_RS04805	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CH48_RS04810	COG2132	Multicopper oxidase
CH48_RS04820	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CH48_RS04825	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
CH48_RS04840	COG3112	Uncharacterised protein family (UPF0231)
CH48_RS04855	COG4977	sequence-specific DNA binding
CH48_RS04865	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CH48_RS04870	COG0508	dehydrogenase complex catalyzes the overall conversion of
CH48_RS04875	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CH48_RS04880	COG2186	Transcriptional regulator
CH48_RS04885	COG1113	amino acid transport
CH48_RS04890	COG3725	Membrane protein required for beta-lactamase induction
CH48_RS04905	COG4969	Belongs to the N-Me-Phe pilin family
CH48_RS04910	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CH48_RS04915	COG1459	type II secretion system
CH48_RS04920	COG0516	GMP reductase activity
CH48_RS04935	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
CH48_RS04940	COG0494	nUDIX hydrolase
CH48_RS04945	COG0653	protein targeting
CH48_RS04965	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CH48_RS04970	COG0849	cell division
CH48_RS04975	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CH48_RS04985	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CH48_RS04990	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CH48_RS04995	COG0772	Belongs to the SEDS family
CH48_RS05005	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CH48_RS05010	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CH48_RS05015	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CH48_RS05020	COG0768	penicillin binding
CH48_RS05025	COG3116	cell division
CH48_RS05030	COG0275	rRNA processing
CH48_RS05035	COG2001	Belongs to the MraZ family
CH48_RS05060	COG0028	Belongs to the TPP enzyme family
CH48_RS05065	COG1022	Amp-dependent synthetase and ligase
CH48_RS05075	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CH48_RS05080	COG0473	3-isopropylmalate dehydrogenase activity
CH48_RS05085	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CH48_RS05100	COG3033	Beta-eliminating lyase
CH48_RS05105	COG0814	amino acid
CH48_RS05115	COG2814	Major facilitator Superfamily
CH48_RS05120	COG1882	Formate acetyltransferase
CH48_RS05125	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CH48_RS05130	COG4533	DNA binding
CH48_RS05145	COG4143	(ABC) transporter
CH48_RS05150	COG1178	ABC-type Fe3 transport system permease component
CH48_RS05160	COG0586	Pfam SNARE associated Golgi protein
CH48_RS05165	COG0417	DNA replication proofreading
CH48_RS05170	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CH48_RS05175	COG1470	cell adhesion involved in biofilm formation
CH48_RS05175	COG1388	LysM domain
CH48_RS05180	COG0564	pseudouridine synthase activity
CH48_RS05185	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CH48_RS05190	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CH48_RS05205	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CH48_RS05210	COG2967	ApaG domain
CH48_RS05215	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CH48_RS05220	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CH48_RS05225	COG3610	response to peptide
CH48_RS05230	COG2966	Psort location CytoplasmicMembrane, score
CH48_RS05235	COG1280	lysine exporter protein (LysE YggA)
CH48_RS05240	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CH48_RS05250	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CH48_RS05255	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CH48_RS05260	COG1047	Peptidyl-prolyl cis-trans
CH48_RS05265	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CH48_RS05270	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CH48_RS05275	COG0196	riboflavin kinase activity
CH48_RS05285	COG0268	Binds directly to 16S ribosomal RNA
CH48_RS05290	COG0583	DNA-binding transcription factor activity
CH48_RS05295	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CH48_RS05300	COG0484	heat shock protein binding
CH48_RS05305	COG0443	Heat shock 70 kDa protein
CH48_RS05310	COG1584	GPR1 FUN34 yaaH family protein
CH48_RS05330	COG0521	Mo-molybdopterin cofactor biosynthetic process
CH48_RS05335	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CH48_RS05340	COG3022	response to hydroperoxide
CH48_RS05355	COG0083	homoserine kinase activity
CH48_RS05370	COG0745	RESPONSE REGULATOR receiver
CH48_RS05375	COG3045	CreA protein
CH48_RS05380	COG2207	Transcriptional regulator
CH48_RS05380	COG3708	Transcriptional regulator
CH48_RS05385	COG0406	alpha-ribazole phosphatase activity
CH48_RS05390	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
CH48_RS05395	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
CH48_RS05400	COG0741	lytic transglycosylase activity
CH48_RS05405	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CH48_RS05415	COG2199	diguanylate cyclase activity
CH48_RS05420	COG2885	chlorophyll binding
CH48_RS05425	COG0488	(ABC) transporter
CH48_RS05440	COG0604	alcohol dehydrogenase
CH48_RS05455	COG0560	Phosphoserine phosphatase
CH48_RS05460	COG3726	membrane protein affecting hemolysin expression
CH48_RS05465	COG0813	purine-nucleoside phosphorylase activity
CH48_RS05470	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
CH48_RS05475	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
CH48_RS05485	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CH48_RS05490	COG0084	hydrolase, TatD family'
CH48_RS05495	COG4667	esterase of the alpha-beta hydrolase superfamily
CH48_RS05500	COG2823	Periplasmic or secreted lipoprotein
CH48_RS05505	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CH48_RS05510	COG0456	acetyltransferase
CH48_RS05515	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
CH48_RS05520	COG2813	Specifically methylates the guanine in position
CH48_RS05525	COG0667	Aldo Keto reductase
CH48_RS05530	COG0583	DNA-binding transcription factor activity
CH48_RS05555	COG4772	TonB-dependent receptor
CH48_RS05590	COG3284	Transcriptional regulator
CH48_RS05620	COG2192	nodulation
CH48_RS05630	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CH48_RS05630	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH48_RS05630	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
CH48_RS05635	COG1461	Dihydroxyacetone kinase
CH48_RS05640	COG2376	Dihydroxyacetone kinase
CH48_RS05650	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CH48_RS05655	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CH48_RS05660	COG2235	arginine
CH48_RS05675	COG0859	PFAM glycosyl transferase family 9
CH48_RS05680	COG1070	Carbohydrate kinase
CH48_RS05685	COG2390	Transcriptional regulator
CH48_RS05690	COG1129	ABC transporter
CH48_RS05695	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH48_RS05700	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH48_RS05705	COG1879	ABC-type sugar transport system periplasmic component
CH48_RS05710	COG1830	Aldolase
CH48_RS05715	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
CH48_RS05730	COG3328	transposase activity
CH48_RS05765	COG0454	-acetyltransferase
CH48_RS05770	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
CH48_RS05770	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CH48_RS05820	COG0795	lipopolysaccharide-transporting ATPase activity
CH48_RS05825	COG0795	lipopolysaccharide-transporting ATPase activity
CH48_RS05830	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CH48_RS05835	COG2927	DNA polymerase III (CHI subunit)
CH48_RS05855	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
CH48_RS05865	COG2731	YhcH YjgK YiaL family protein
CH48_RS05875	COG0601	transmembrane transport
CH48_RS05880	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CH48_RS05885	COG0444	Belongs to the ABC transporter superfamily
CH48_RS05890	COG4608	Belongs to the ABC transporter superfamily
CH48_RS05920	COG2188	Transcriptional regulator
CH48_RS05925	COG3624	Phosphonate C-P lyase system protein PhnG
CH48_RS05930	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
CH48_RS05935	COG3626	phosphonate metabolism
CH48_RS05940	COG3627	carbon phosphorus lyase activity
CH48_RS05945	COG4107	phosphonate C-P lyase system protein PhnK
CH48_RS05950	COG4778	phosphonate C-P lyase system protein PhnL
CH48_RS05955	COG3454	Phosphonate metabolism
CH48_RS05960	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
CH48_RS05965	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CH48_RS05970	COG0702	epimerase
CH48_RS05985	COG3787	Belongs to the UPF0306 family
CH48_RS05995	COG3842	ATPase activity
CH48_RS06000	COG0395	ABC-type sugar transport system, permease component
CH48_RS06005	COG1175	transmembrane transport
CH48_RS06010	COG1653	transport
CH48_RS06025	COG1982	Orn Lys Arg decarboxylase major
CH48_RS06030	COG0531	amino acid
CH48_RS06035	COG2827	Endonuclease containing a URI domain
CH48_RS06040	COG3153	acetyltransferase
CH48_RS06045	COG3154	lipid carrier protein
CH48_RS06050	COG0826	peptidase U32
CH48_RS06055	COG0826	peptidase U32
CH48_RS06060	COG3681	Belongs to the UPF0597 family
CH48_RS06065	COG0814	amino acid
CH48_RS06075	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CH48_RS06085	COG0513	Belongs to the DEAD box helicase family
CH48_RS06095	COG1185	polyribonucleotide nucleotidyltransferase activity
CH48_RS06100	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CH48_RS06105	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CH48_RS06110	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CH48_RS06115	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CH48_RS06120	COG0195	Participates in both transcription termination and antitermination
CH48_RS06125	COG0779	Required for maturation of 30S ribosomal subunits
CH48_RS06140	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CH48_RS06145	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CH48_RS06150	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CH48_RS06160	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
CH48_RS06165	COG1534	Rna-binding protein
CH48_RS06175	COG2027	D-alanyl-D-alanine carboxypeptidase
CH48_RS06180	COG0745	RESPONSE REGULATOR receiver
CH48_RS06185	COG0642	Histidine kinase
CH48_RS06190	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CH48_RS06195	COG0697	spore germination
CH48_RS06200	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CH48_RS06205	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CH48_RS06210	COG0142	geranyltranstransferase activity
CH48_RS06220	COG3423	Transcriptional regulator
CH48_RS06225	COG0039	L-malate dehydrogenase activity
CH48_RS06230	COG1438	arginine binding
CH48_RS06240	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CH48_RS06250	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CH48_RS06255	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
CH48_RS06265	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CH48_RS06275	COG2105	PFAM AIG2 family protein
CH48_RS06290	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CH48_RS06295	COG1253	flavin adenine dinucleotide binding
CH48_RS06305	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
CH48_RS06310	COG1218	3'(2'),5'-bisphosphate nucleotidase
CH48_RS06315	COG0737	Belongs to the 5'-nucleotidase family
CH48_RS06325	COG0545	Peptidyl-prolyl cis-trans isomerase
CH48_RS06330	COG3061	Opacity-associated protein A
CH48_RS06340	COG0359	binds to the 23S rRNA
CH48_RS06345	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CH48_RS06350	COG2965	DNA replication, synthesis of RNA primer
CH48_RS06355	COG0360	Binds together with S18 to 16S ribosomal RNA
CH48_RS06365	COG1073	alpha beta
CH48_RS06370	COG3650	response to hydrogen peroxide
CH48_RS06375	COG1960	acyl-CoA dehydrogenase activity
CH48_RS06380	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CH48_RS06385	COG0557	exoribonuclease II activity
CH48_RS06390	COG1959	2 iron, 2 sulfur cluster binding
CH48_RS06395	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CH48_RS06400	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
CH48_RS06405	COG0330	HflC and HflK could
CH48_RS06410	COG0330	HflC and HflK could
CH48_RS06415	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CH48_RS06420	COG1923	regulation of RNA biosynthetic process
CH48_RS06425	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CH48_RS06430	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CH48_RS06435	COG0860	N-Acetylmuramoyl-L-alanine amidase
CH48_RS06440	COG0802	atpase or kinase
CH48_RS06445	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CH48_RS06445	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CH48_RS06450	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CH48_RS06465	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
CH48_RS06470	COG1162	GTPase activity
CH48_RS06475	COG0688	phosphatidylethanolamine metabolic process
CH48_RS06480	COG1511	domain protein
CH48_RS06480	COG3264	Mechanosensitive ion channel
CH48_RS06485	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
CH48_RS06490	COG1053	succinate dehydrogenase
CH48_RS06495	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CH48_RS06500	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
CH48_RS06505	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
CH48_RS06525	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CH48_RS06545	COG0459	protein refolding
CH48_RS06550	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CH48_RS06565	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CH48_RS06575	COG4232	protein-disulfide reductase activity
CH48_RS06580	COG1929	Belongs to the glycerate kinase type-1 family
CH48_RS06585	COG1309	transcriptional regulator
CH48_RS06595	COG1882	Formate acetyltransferase
CH48_RS06600	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CH48_RS06605	COG0814	amino acid
CH48_RS06610	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CH48_RS06620	COG3721	Heme iron utilization protein
CH48_RS06640	COG3720	iron ion transport
CH48_RS06645	COG4558	Periplasmic binding protein
CH48_RS06650	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CH48_RS06655	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CH48_RS06660	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CH48_RS06665	COG4774	siderophore transport
CH48_RS06670	COG1511	domain protein
CH48_RS06670	COG3264	Mechanosensitive ion channel
CH48_RS06675	COG4115	mRNA cleavage
CH48_RS06680	COG2161	toxin-antitoxin pair type II binding
CH48_RS06685	COG0612	Peptidase, M16
CH48_RS06690	COG4178	(ABC) transporter
CH48_RS06695	COG4771	TonB-dependent receptor
CH48_RS06700	COG3712	iron ion homeostasis
CH48_RS06715	COG0425	Belongs to the sulfur carrier protein TusA family
CH48_RS06720	COG2391	methyltransferase activity
CH48_RS06875	COG0784	Response regulator, receiver
CH48_RS06875	COG2205	protein histidine kinase activity
CH48_RS06875	COG5002	protein histidine kinase activity
CH48_RS06880	COG2197	response regulator
CH48_RS06885	COG1301	dicarboxylic acid transport
CH48_RS06890	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CH48_RS06895	COG3162	membrane
CH48_RS06900	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CH48_RS06940	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CH48_RS06945	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CH48_RS06950	COG0009	L-threonylcarbamoyladenylate synthase
CH48_RS06955	COG0551	DNA topoisomerase type I activity
CH48_RS06965	COG0758	DNA mediated transformation
CH48_RS06970	COG0242	peptide deformylase activity
CH48_RS06975	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CH48_RS06980	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CH48_RS06980	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CH48_RS06990	COG1970	mechanosensitive ion channel activity
CH48_RS07000	COG3036	rescue of stalled ribosome
CH48_RS07005	COG0789	Transcriptional regulator
CH48_RS07015	COG0203	ribosomal protein L17
CH48_RS07020	COG0202	RNA polymerase activity
CH48_RS07025	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CH48_RS07030	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CH48_RS07035	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CH48_RS07040	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CH48_RS07045	COG0201	protein transport
CH48_RS07050	COG0200	Binds to the 23S rRNA
CH48_RS07055	COG1841	ribosomal large subunit assembly
CH48_RS07060	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CH48_RS07065	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CH48_RS07070	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CH48_RS07080	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CH48_RS07085	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CH48_RS07090	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CH48_RS07095	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CH48_RS07100	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CH48_RS07105	COG0255	Belongs to the universal ribosomal protein uL29 family
CH48_RS07110	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CH48_RS07115	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CH48_RS07120	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CH48_RS07125	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CH48_RS07130	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CH48_RS07135	COG0089	rRNA binding
CH48_RS07140	COG0088	Forms part of the polypeptide exit tunnel
CH48_RS07145	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CH48_RS07150	COG0051	transcription antitermination factor activity, RNA binding
CH48_RS07165	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CH48_RS07175	COG0049	tRNA binding
CH48_RS07180	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CH48_RS07185	COG2168	tRNA wobble position uridine thiolation
CH48_RS07190	COG2923	Belongs to the DsrF TusC family
CH48_RS07195	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
CH48_RS07200	COG2964	Protein conserved in bacteria
CH48_RS07205	COG0545	Peptidyl-prolyl cis-trans isomerase
CH48_RS07210	COG2900	Belongs to the SlyX family
CH48_RS07215	COG1047	Peptidyl-prolyl cis-trans
CH48_RS07220	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
CH48_RS07230	COG2249	NAD(P)H dehydrogenase (quinone) activity
CH48_RS07235	COG0488	(ABC) transporter
CH48_RS07240	COG1216	Glycosyl transferase, family 2
CH48_RS07250	COG2175	clavaminate synthase activity
CH48_RS07255	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CH48_RS07265	COG4521	taurine ABC transporter
CH48_RS07280	COG0429	hydrolase of the alpha beta-hydrolase fold
CH48_RS07285	COG3089	Belongs to the UPF0270 family
CH48_RS07290	COG3954	Phosphoribulokinase
CH48_RS07295	COG1765	OsmC-like protein
CH48_RS07305	COG1289	transmembrane transporter activity
CH48_RS07320	COG0433	COG0433 Predicted ATPase
CH48_RS07325	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CH48_RS07330	COG1486	melibiose metabolic process
CH48_RS07340	COG0738	Major facilitator superfamily
CH48_RS07345	COG0402	S-adenosylhomocysteine deaminase activity
CH48_RS07350	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CH48_RS07365	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CH48_RS07365	COG1648	precorrin-2 dehydrogenase activity
CH48_RS07370	COG0180	Tryptophanyl-tRNA synthetase
CH48_RS07380	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CH48_RS07400	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CH48_RS07405	COG4796	Type ii and iii secretion system protein
CH48_RS07430	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CH48_RS07435	COG0494	nUDIX hydrolase
CH48_RS07445	COG1011	Hydrolase
CH48_RS07450	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CH48_RS07460	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
CH48_RS07480	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CH48_RS07505	COG2183	response to ionizing radiation
CH48_RS07510	COG1918	ferrous iron import across plasma membrane
CH48_RS07515	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CH48_RS07530	COG0596	Alpha beta hydrolase
CH48_RS07540	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CH48_RS07540	COG0316	Belongs to the HesB IscA family
CH48_RS07550	COG1640	4-alpha-glucanotransferase
CH48_RS07555	COG0058	SHG alpha-glucan phosphorylase activity
CH48_RS07565	COG0058	SHG alpha-glucan phosphorylase activity
CH48_RS07570	COG2909	trisaccharide binding
CH48_RS07585	COG0705	Rhomboid family
CH48_RS07590	COG1349	DNA-binding transcription factor activity
CH48_RS07600	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CH48_RS07605	COG0058	SHG alpha-glucan phosphorylase activity
CH48_RS07610	COG0297	glycogen (starch) synthase activity
CH48_RS07620	COG1523	belongs to the glycosyl hydrolase 13 family
CH48_RS07625	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CH48_RS07630	COG3275	phosphorelay sensor kinase activity
CH48_RS07650	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CH48_RS07655	COG2095	MarC family integral membrane protein
CH48_RS07660	COG3265	gluconokinase activity
CH48_RS07665	COG2610	gluconate transmembrane transporter activity
CH48_RS07670	COG1609	Transcriptional regulator
CH48_RS07675	COG1741	Belongs to the pirin family
CH48_RS07680	COG1247	-acetyltransferase
CH48_RS07685	COG1082	Xylose isomerase domain protein TIM barrel
CH48_RS07690	COG0673	inositol 2-dehydrogenase activity
CH48_RS07700	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CH48_RS07710	COG3718	enzyme involved in inositol metabolism
CH48_RS07720	COG2814	Major facilitator Superfamily
CH48_RS07725	COG0583	DNA-binding transcription factor activity
CH48_RS07735	COG0561	phosphatase activity
CH48_RS07745	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
CH48_RS07745	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
CH48_RS07750	COG0583	DNA-binding transcription factor activity
CH48_RS07755	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CH48_RS07755	COG1648	precorrin-2 dehydrogenase activity
CH48_RS07765	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CH48_RS07775	COG4865	methylaspartate mutase activity
CH48_RS07780	COG3799	methylaspartate ammonia-lyase activity
CH48_RS07795	COG1301	dicarboxylic acid transport
CH48_RS07800	COG2081	HI0933 family
CH48_RS07805	COG0306	phosphate transporter
CH48_RS07815	COG0589	response to stress
CH48_RS07830	COG0742	ribosomal rna small subunit methyltransferase
CH48_RS07840	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
CH48_RS07845	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CH48_RS07855	COG1295	ribonuclease BN
CH48_RS07860	COG2134	cdp-diacylglycerol pyrophosphatase
CH48_RS07865	COG2982	Protein involved in outer membrane biogenesis
CH48_RS07870	COG2200	EAL domain
CH48_RS07875	COG1942	4-Oxalocrotonate Tautomerase
CH48_RS07880	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CH48_RS07885	COG0612	Peptidase, M16
CH48_RS07890	COG1301	dicarboxylic acid transport
CH48_RS07905	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CH48_RS07910	COG2200	EAL domain
CH48_RS07910	COG2199	diguanylate cyclase activity
CH48_RS07925	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
CH48_RS07930	COG1215	transferase activity, transferring glycosyl groups
CH48_RS07935	COG1215	transferase activity, transferring glycosyl groups
CH48_RS07940	COG1192	Involved in chromosome partitioning
CH48_RS07960	COG2194	sulfuric ester hydrolase activity
CH48_RS07965	COG4608	Belongs to the ABC transporter superfamily
CH48_RS07970	COG0444	Belongs to the ABC transporter superfamily
CH48_RS07975	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CH48_RS07980	COG0601	transmembrane transport
CH48_RS07985	COG0747	negative chemotaxis
CH48_RS07995	COG1764	response to oxidative stress
CH48_RS08000	COG2194	sulfuric ester hydrolase activity
CH48_RS08005	COG2197	response regulator
CH48_RS08010	COG3851	Histidine kinase
CH48_RS08015	COG2271	Major facilitator Superfamily
CH48_RS08030	COG2831	hemolysin activation secretion protein
CH48_RS08035	COG3210	domain, Protein
CH48_RS08045	COG3328	transposase activity
CH48_RS08070	COG1609	Transcriptional regulator
CH48_RS08075	COG1940	carbohydrate kinase activity
CH48_RS08080	COG1447	Phosphotransferase system cellobiose-specific component IIA
CH48_RS08085	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CH48_RS08090	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CH48_RS08095	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CH48_RS08110	COG2723	6-phospho-beta-galactosidase activity
CH48_RS08115	COG1482	cell wall glycoprotein biosynthetic process
CH48_RS08130	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
CH48_RS08135	COG2986	histidine ammonia-lyase
CH48_RS08170	COG0582	viral genome integration into host DNA
CH48_RS08175	COG1609	Transcriptional regulator
CH48_RS08175	COG2207	Transcriptional regulator
CH48_RS08180	COG4214	carbohydrate transport
CH48_RS08190	COG4213	ABC transporter substrate-binding protein
CH48_RS08195	COG2115	Belongs to the xylose isomerase family
CH48_RS08200	COG1070	Carbohydrate kinase
CH48_RS08205	COG3121	Chaperone
CH48_RS08220	COG3274	enterobacterial common antigen metabolic process
CH48_RS08230	COG3276	selenocysteine insertion sequence binding
CH48_RS08235	COG1921	L-seryl-tRNASec selenium transferase activity
CH48_RS08240	COG3058	Necessary for formate dehydrogenase activity
CH48_RS08245	COG2864	formate dehydrogenase
CH48_RS08250	COG0437	4 iron, 4 sulfur cluster binding
CH48_RS08255	COG3383	formate dehydrogenase (NAD+) activity
CH48_RS08255	COG0243	molybdopterin cofactor binding
CH48_RS08260	COG0243	molybdopterin cofactor binding
CH48_RS08260	COG3383	formate dehydrogenase (NAD+) activity
CH48_RS08265	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CH48_RS08270	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CH48_RS08275	COG0840	transmembrane signaling receptor activity
CH48_RS08280	COG2258	MOSC domain
CH48_RS08300	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CH48_RS08310	COG3722	fumarate hydratase activity
CH48_RS08315	COG0246	Mannitol dehydrogenase
CH48_RS08320	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH48_RS08320	COG2213	PTS system mannitol-specific
CH48_RS08330	COG0751	glycine-tRNA ligase activity
CH48_RS08335	COG0752	glycyl-tRNA synthetase alpha subunit
CH48_RS08340	COG2818	Glycosylase
CH48_RS08345	COG0456	acetyltransferase
CH48_RS08375	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CH48_RS08380	COG0366	Alpha amylase catalytic
CH48_RS08385	COG3977	Valine--pyruvate aminotransferase
CH48_RS08390	COG0569	domain protein
CH48_RS08390	COG2985	domain, Protein
CH48_RS08405	COG5645	(Lipo)protein
CH48_RS08410	COG0823	Involved in the tonB-independent uptake of proteins
CH48_RS08420	COG2423	ornithine cyclodeaminase activity
CH48_RS08425	COG0561	phosphatase activity
CH48_RS08430	COG0187	DNA topoisomerase II activity
CH48_RS08435	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CH48_RS08440	COG0592	DNA-directed DNA polymerase activity
CH48_RS08445	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CH48_RS08450	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CH48_RS08455	COG0594	ribonuclease P activity
CH48_RS08465	COG0706	membrane insertase activity
CH48_RS08470	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CH48_RS08475	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CH48_RS08485	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CH48_RS08490	COG2011	ABC-type metal ion transport system permease component
CH48_RS08495	COG0840	transmembrane signaling receptor activity
CH48_RS08500	COG0431	NADPH-dependent FMN reductase
CH48_RS08510	COG4566	intracellular signal transduction
CH48_RS08520	COG2252	PERMEase
CH48_RS08525	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CH48_RS08530	COG0765	amino acid transport
CH48_RS08535	COG0765	amino acid transport
CH48_RS08540	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CH48_RS08550	COG0704	Plays a role in the regulation of phosphate uptake
CH48_RS08560	COG0581	inorganic phosphate transmembrane transporter activity
CH48_RS08565	COG0573	inorganic phosphate transmembrane transporter activity
CH48_RS08570	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CH48_RS08585	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CH48_RS08590	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CH48_RS08595	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CH48_RS08600	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CH48_RS08605	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CH48_RS08610	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CH48_RS08615	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CH48_RS08625	COG0356	it plays a direct role in the translocation of protons across the membrane
CH48_RS08630	COG3312	ion transport
CH48_RS08635	COG0357	Ribosomal RNA small subunit methyltransferase G
CH48_RS08640	COG0445	tRNA wobble uridine modification
CH48_RS08645	COG0716	FMN binding
CH48_RS08650	COG1522	sequence-specific DNA binding
CH48_RS08655	COG2502	aspartate--ammonia ligase
CH48_RS08665	COG2425	protein containing a von Willebrand factor type A (vWA) domain
CH48_RS08670	COG0714	Associated with various cellular activities
CH48_RS08675	COG3158	transport of potassium into the cell
CH48_RS08680	COG1869	D-ribose catabolic process
CH48_RS08690	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH48_RS08695	COG1879	ABC-type sugar transport system periplasmic component
CH48_RS08700	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CH48_RS08705	COG1609	Transcriptional regulator
CH48_RS08715	COG2186	Transcriptional regulator
CH48_RS08750	COG1763	Mo-molybdopterin cofactor biosynthetic process
CH48_RS08760	COG3084	Protein conserved in bacteria
CH48_RS08765	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CH48_RS08770	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CH48_RS08775	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CH48_RS08775	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CH48_RS08780	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CH48_RS08785	COG3078	GTPase activator activity
CH48_RS08790	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CH48_RS08800	COG3852	Histidine kinase
CH48_RS08820	COG1011	Hydrolase
CH48_RS08825	COG1295	ribonuclease BN
CH48_RS08830	COG1490	D-aminoacyl-tRNA deacylase activity
CH48_RS08835	COG0456	acetyltransferase
CH48_RS08840	COG3423	Transcriptional regulator
CH48_RS08860	COG2982	Protein involved in outer membrane biogenesis
CH48_RS08865	COG2233	PERMEase
CH48_RS08870	COG0786	glutamate:sodium symporter activity
CH48_RS08880	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CH48_RS08885	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CH48_RS08890	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CH48_RS08895	COG1758	RNA polymerase activity
CH48_RS08910	COG2860	membrane
CH48_RS08920	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CH48_RS08925	COG1024	Enoyl-CoA hydratase
CH48_RS08930	COG5001	Diguanylate cyclase
CH48_RS08945	COG1561	YicC-like family, N-terminal region
CH48_RS08950	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CH48_RS08955	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CH48_RS08960	COG1309	transcriptional regulator
CH48_RS08965	COG0756	dUTP diphosphatase activity
CH48_RS08970	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CH48_RS08975	COG2003	Belongs to the UPF0758 family
CH48_RS08980	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CH48_RS08985	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CH48_RS08990	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CH48_RS08995	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CH48_RS09005	COG1519	Transferase
CH48_RS09010	COG0859	PFAM glycosyl transferase family 9
CH48_RS09015	COG0859	PFAM glycosyl transferase family 9
CH48_RS09020	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CH48_RS09025	COG0156	8-amino-7-oxononanoate synthase activity
CH48_RS09030	COG1063	alcohol dehydrogenase
CH48_RS09050	COG2861	carbohydrate metabolic process
CH48_RS09055	COG4942	peptidase
CH48_RS09060	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CH48_RS09065	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CH48_RS09070	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CH48_RS09075	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
CH48_RS09080	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CH48_RS09085	COG1045	serine acetyltransferase
CH48_RS09090	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CH48_RS09095	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CH48_RS09095	COG2169	Transcriptional regulator
CH48_RS09100	COG2205	protein histidine kinase activity
CH48_RS09105	COG0745	RESPONSE REGULATOR receiver
CH48_RS09110	COG3678	ATP-independent chaperone mediated protein folding
CH48_RS09115	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CH48_RS09125	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
CH48_RS09135	COG0149	triose-phosphate isomerase activity
CH48_RS09145	COG3152	Membrane
CH48_RS09165	COG2814	Major facilitator Superfamily
CH48_RS09170	COG1494	fructose-1,6-bisphosphatase
CH48_RS09180	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CH48_RS09185	COG3074	FtsZ-dependent cytokinesis
CH48_RS09190	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CH48_RS09195	COG1575	Belongs to the MenA family. Type 1 subfamily
CH48_RS09200	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CH48_RS09205	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CH48_RS09210	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CH48_RS09215	COG1609	Transcriptional regulator
CH48_RS09220	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CH48_RS09225	COG0254	rRNA binding
CH48_RS09230	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
CH48_RS09235	COG0626	cystathionine gamma-synthase activity
CH48_RS09240	COG0527	aspartate kinase activity
CH48_RS09240	COG0460	homoserine dehydrogenase
CH48_RS09250	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CH48_RS09265	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CH48_RS09270	COG0165	Argininosuccinate lyase
CH48_RS09275	COG1629	transport
CH48_RS09310	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CH48_RS09315	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CH48_RS09315	COG0678	peroxiredoxin activity
CH48_RS09325	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CH48_RS09330	COG1309	transcriptional regulator
CH48_RS09345	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CH48_RS09355	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CH48_RS09395	COG1879	ABC-type sugar transport system periplasmic component
CH48_RS09400	COG1129	ABC transporter
CH48_RS09405	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH48_RS09410	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH48_RS09415	COG0583	DNA-binding transcription factor activity
CH48_RS09420	COG3085	chromosome segregation
CH48_RS09435	COG3978	acetolactate synthase activity
CH48_RS09440	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CH48_RS09445	COG0129	dihydroxy-acid dehydratase activity
CH48_RS09470	COG0583	DNA-binding transcription factor activity
CH48_RS09475	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CH48_RS09500	COG3121	Chaperone
CH48_RS09515	COG3121	Chaperone
CH48_RS09525	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CH48_RS09540	COG0248	Ppx GppA phosphatase
CH48_RS09550	COG3118	belongs to the thioredoxin family
CH48_RS09555	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CH48_RS09565	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CH48_RS09570	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
CH48_RS09575	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CH48_RS09580	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CH48_RS09585	COG1088	dTDP-glucose 4,6-dehydratase activity
CH48_RS09590	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CH48_RS09595	COG0456	acetyltransferase
CH48_RS09600	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CH48_RS09605	COG2244	polysaccharide biosynthetic process
CH48_RS09610	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CH48_RS09655	COG3071	HemY protein
CH48_RS09660	COG2959	enzyme of heme biosynthesis
CH48_RS09665	COG1587	Uroporphyrinogen-III synthase
CH48_RS09670	COG0181	hydroxymethylbilane synthase activity
CH48_RS09675	COG3072	Adenylate cyclase
CH48_RS09680	COG1965	Belongs to the frataxin family
CH48_RS09690	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CH48_RS09695	COG3159	Protein conserved in bacteria
CH48_RS09700	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
CH48_RS09705	COG1011	Hydrolase
CH48_RS09710	COG0210	DNA helicase
CH48_RS09720	COG5441	Belongs to the UPF0261 family
CH48_RS09725	COG5564	TIM-barrel signal transduction protein
CH48_RS09740	COG2050	protein possibly involved in aromatic compounds catabolism
CH48_RS09745	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
CH48_RS09750	COG0514	ATP-dependent DNA helicase (RecQ)
CH48_RS09755	COG1280	lysine exporter protein (LysE YggA)
CH48_RS09760	COG1280	lysine exporter protein (LysE YggA)
CH48_RS09765	COG2267	carboxylic ester hydrolase activity
CH48_RS09770	COG0561	phosphatase activity
CH48_RS09775	COG0584	glycerophosphoryl diester phosphodiesterase
CH48_RS09780	COG2271	Major facilitator Superfamily
CH48_RS09785	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CH48_RS09790	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
CH48_RS09795	COG0247	lactate metabolic process
CH48_RS09805	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
CH48_RS09810	COG0425	Belongs to the sulfur carrier protein TusA family
CH48_RS09815	COG2217	Heavy metal translocating P-type atpase
CH48_RS09820	COG3714	YhhN family
CH48_RS09835	COG3776	membrane
CH48_RS09840	COG0742	ribosomal rna small subunit methyltransferase
CH48_RS09845	COG0552	protein localization to endoplasmic reticulum
CH48_RS09850	COG2884	Cell division ATP-binding protein ftsE
CH48_RS09855	COG2177	Part of the ABC transporter FtsEX involved in
CH48_RS09880	COG0683	leucine binding
CH48_RS09890	COG4177	L-phenylalanine transmembrane transporter activity
CH48_RS09900	COG0410	ABC transporter
CH48_RS09935	COG1653	transport
CH48_RS09940	COG1175	transmembrane transport
CH48_RS09945	COG0395	ABC-type sugar transport system, permease component
CH48_RS09950	COG3842	ATPase activity
CH48_RS09955	COG0584	glycerophosphoryl diester phosphodiesterase
CH48_RS09960	COG0679	Auxin Efflux Carrier
CH48_RS09965	COG0697	spore germination
CH48_RS09970	COG0583	DNA-binding transcription factor activity
CH48_RS09975	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CH48_RS09980	COG0412	Dienelactone hydrolase
CH48_RS10000	COG1966	Carbon starvation protein
CH48_RS10005	COG0586	Pfam SNARE associated Golgi protein
CH48_RS10010	COG1322	Protein conserved in bacteria
CH48_RS10015	COG2226	methyltransferase
CH48_RS10025	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CH48_RS10030	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CH48_RS10035	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CH48_RS10040	COG0805	protein transport
CH48_RS10060	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CH48_RS10070	COG0183	Belongs to the thiolase family
CH48_RS10075	COG1250	3-hydroxyacyl-CoA dehydrogenase
CH48_RS10075	COG1024	Enoyl-CoA hydratase
CH48_RS10080	COG0006	proline dipeptidase activity
CH48_RS10085	COG1739	Uncharacterized protein family UPF0029
CH48_RS10090	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CH48_RS10135	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
CH48_RS10135	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
CH48_RS10140	COG1072	(Pantothenic acid kinase))
CH48_RS10170	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CH48_RS10180	COG0250	Participates in transcription elongation, termination and antitermination
CH48_RS10185	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CH48_RS10190	COG0081	regulation of translation
CH48_RS10195	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CH48_RS10200	COG0222	ribosome binding
CH48_RS10205	COG0085	RNA polymerase activity
CH48_RS10210	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CH48_RS10225	COG2022	thiamine diphosphate biosynthetic process
CH48_RS10230	COG2104	thiamine diphosphate biosynthetic process
CH48_RS10235	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CH48_RS10250	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
CH48_RS10255	COG2816	NAD+ diphosphatase activity
CH48_RS10260	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CH48_RS10265	COG1515	deoxyribonuclease V activity
CH48_RS10285	COG0151	Belongs to the GarS family
CH48_RS10290	COG0138	bifunctional purine biosynthesis protein purh
CH48_RS10330	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
CH48_RS10335	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CH48_RS10340	COG2224	Isocitrate lyase
CH48_RS10345	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
CH48_RS10350	COG1414	Transcriptional regulator
CH48_RS10375	COG0527	aspartate kinase activity
CH48_RS10380	COG0166	Belongs to the GPI family
CH48_RS10390	COG3833	ABC-type maltose transport systems, permease component
CH48_RS10395	COG1175	transmembrane transport
CH48_RS10400	COG2182	Extracellular solute-binding protein
CH48_RS10410	COG4580	involved in the transport of maltose and maltodextrins
CH48_RS10425	COG3161	chorismate lyase activity
CH48_RS10430	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CH48_RS10435	COG2937	Belongs to the GPAT DAPAT family
CH48_RS10440	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CH48_RS10445	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CH48_RS10450	COG3237	CsbD-like
CH48_RS10455	COG0735	belongs to the Fur family
CH48_RS10465	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CH48_RS10495	COG1448	Aminotransferase
CH48_RS10505	COG2315	Protein conserved in bacteria
CH48_RS10510	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CH48_RS10520	COG3550	peptidyl-serine autophosphorylation
CH48_RS10535	COG2252	PERMEase
CH48_RS10540	COG0025	NhaP-type Na H and K H
CH48_RS10545	COG0583	DNA-binding transcription factor activity
CH48_RS10550	COG1380	Effector of murein hydrolase LrgA
CH48_RS10560	COG1126	abc transporter atp-binding protein
CH48_RS10565	COG0765	amino acid transport
CH48_RS10570	COG4597	amino acid ABC transporter
CH48_RS10575	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CH48_RS10585	COG1560	Kdo2-lipid A biosynthetic process
CH48_RS10590	COG0471	metal ion transport
CH48_RS10595	COG1278	Cold shock
CH48_RS10600	COG1278	Cold shock
CH48_RS10605	COG3133	Outer membrane lipoprotein
CH48_RS10615	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
CH48_RS10620	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CH48_RS10625	COG2264	protein methyltransferase activity
CH48_RS10630	COG4145	pantothenate transmembrane transporter activity
CH48_RS10635	COG3924	membrane
CH48_RS10640	COG0439	Biotin carboxylase
CH48_RS10645	COG0511	ligase activity, forming carbon-carbon bonds
CH48_RS10650	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CH48_RS10655	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
CH48_RS10665	COG0604	alcohol dehydrogenase
CH48_RS10670	COG2200	EAL domain
CH48_RS10670	COG2199	diguanylate cyclase activity
CH48_RS10675	COG1077	Cell shape determining protein MreB Mrl
CH48_RS10680	COG1792	Involved in formation and maintenance of cell shape
CH48_RS10685	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
CH48_RS10690	COG0424	maF-like protein
CH48_RS10700	COG3164	Protein of unknown function
CH48_RS10705	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CH48_RS10710	COG0312	modulator of DNA gyrase
CH48_RS10775	COG0583	DNA-binding transcription factor activity
CH48_RS10785	COG1566	PFAM secretion protein HlyD family protein
CH48_RS10790	COG1289	transmembrane transporter activity
CH48_RS10805	COG2732	(Barnase) inhibitor
CH48_RS10810	COG3028	Belongs to the UPF0307 family
CH48_RS10815	COG0312	modulator of DNA gyrase
CH48_RS10825	COG3783	Cytochrome b(562)
CH48_RS10830	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CH48_RS10860	COG3964	amidohydrolase
CH48_RS10875	COG2706	6-phosphogluconolactonase activity
CH48_RS10880	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH48_RS10880	COG3711	transcriptional antiterminator
CH48_RS10885	COG3093	addiction module antidote protein HigA
CH48_RS10895	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CH48_RS10905	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CH48_RS10905	COG1263	PTS System
CH48_RS10910	COG0366	Alpha amylase catalytic
CH48_RS10930	COG2308	Evidence 4 Homologs of previously reported genes of
CH48_RS10940	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
CH48_RS10945	COG0540	Belongs to the ATCase OTCase family
CH48_RS10950	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH48_RS10955	COG1660	Displays ATPase and GTPase activities
CH48_RS10970	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CH48_RS10975	COG1137	ATPase activity
CH48_RS10980	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
CH48_RS10985	COG3117	lipopolysaccharide transmembrane transporter activity
CH48_RS10990	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
CH48_RS10995	COG0517	IMP dehydrogenase activity
CH48_RS10995	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CH48_RS11000	COG0530	calcium, potassium:sodium antiporter activity
CH48_RS11005	COG1127	ABC transporter
CH48_RS11010	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CH48_RS11015	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CH48_RS11020	COG2854	intermembrane phospholipid transfer
CH48_RS11025	COG3113	response to antibiotic
CH48_RS11030	COG5007	Belongs to the BolA IbaG family
CH48_RS11035	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CH48_RS11040	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CH48_RS11045	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CH48_RS11050	COG3105	Protein conserved in bacteria
CH48_RS11055	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
CH48_RS11060	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CH48_RS11065	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CH48_RS11070	COG0625	glutathione transferase activity
CH48_RS11075	COG2969	positive regulation of protein catabolic process
CH48_RS11090	COG0493	'glutamate synthase
CH48_RS11095	COG0067	glutamate synthase
CH48_RS11095	COG0070	glutamate synthase
CH48_RS11095	COG0069	glutamate synthase activity
CH48_RS11100	COG1242	4 iron, 4 sulfur cluster binding
CH48_RS11105	COG0784	Response regulator, receiver
CH48_RS11105	COG2198	Histidine kinase
CH48_RS11105	COG5002	protein histidine kinase activity
CH48_RS11110	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
CH48_RS11115	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CH48_RS11120	COG2823	Periplasmic or secreted lipoprotein
CH48_RS11125	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
CH48_RS11130	COG0792	nuclease activity
CH48_RS11140	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CH48_RS11155	COG3121	Chaperone
CH48_RS11175	COG0667	Aldo Keto reductase
CH48_RS11180	COG1064	alcohol dehydrogenase
CH48_RS11185	COG1741	Belongs to the pirin family
CH48_RS11190	COG0583	DNA-binding transcription factor activity
CH48_RS11195	COG0435	Glutathione S-transferase
CH48_RS11200	COG2259	Doxx family
CH48_RS11210	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
CH48_RS11215	COG4575	ribosome binding
CH48_RS11230	COG0586	Pfam SNARE associated Golgi protein
CH48_RS11245	COG2271	Major facilitator Superfamily
CH48_RS11250	COG1904	glucuronate isomerase
CH48_RS11255	COG0246	Mannitol dehydrogenase
CH48_RS11260	COG2721	sulfolactate sulfo-lyase activity
CH48_RS11270	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
CH48_RS11275	COG0861	Integral membrane protein TerC family
CH48_RS11285	COG0673	inositol 2-dehydrogenase activity
CH48_RS11290	COG1451	nucleotide metabolic process
CH48_RS11310	COG2813	Specifically methylates the guanine in position
CH48_RS11320	COG1902	pentaerythritol trinitrate reductase activity
CH48_RS11320	COG0446	pyridine nucleotide-disulphide oxidoreductase
CH48_RS11330	COG3247	response to pH
CH48_RS11340	COG0076	glutamate decarboxylase activity
CH48_RS11345	COG0531	amino acid
CH48_RS11355	COG1263	PTS System
CH48_RS11355	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CH48_RS11360	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CH48_RS11370	COG1472	Belongs to the glycosyl hydrolase 3 family
CH48_RS11380	COG3876	Protein conserved in bacteria
CH48_RS11400	COG0358	DNA primase activity
CH48_RS11405	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CH48_RS11410	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CH48_RS11415	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CH48_RS11420	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CH48_RS11425	COG1968	undecaprenyl-diphosphatase activity
CH48_RS11430	COG0617	tRNA 3'-terminal CCA addition
CH48_RS11435	COG4991	sh3 domain protein
CH48_RS11440	COG3025	triphosphatase activity
CH48_RS11445	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
CH48_RS11450	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
CH48_RS11450	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CH48_RS11455	COG0531	amino acid
CH48_RS11465	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CH48_RS11470	COG3384	dioxygenase
CH48_RS11475	COG0754	glutathionylspermidine amidase activity
CH48_RS11480	COG5463	Belongs to the UPF0441 family
CH48_RS11485	COG1538	Outer membrane efflux protein
CH48_RS11490	COG0494	nUDIX hydrolase
CH48_RS11495	COG3151	Protein conserved in bacteria
CH48_RS11500	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CH48_RS11505	COG3150	esterase
CH48_RS11520	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
CH48_RS11525	COG2249	NAD(P)H dehydrogenase (quinone) activity
CH48_RS11530	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CH48_RS11540	COG2132	Multicopper oxidase
CH48_RS11550	COG0656	L-ascorbic acid biosynthetic process
CH48_RS11555	COG1979	alcohol dehydrogenase
CH48_RS11560	COG2207	Transcriptional regulator
CH48_RS11565	COG0586	Pfam SNARE associated Golgi protein
CH48_RS11570	COG0626	cystathionine gamma-synthase activity
CH48_RS11580	COG0848	biopolymer transport protein
CH48_RS11630	COG4964	Belongs to the GSP D family
CH48_RS11660	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CH48_RS11665	COG2135	peptidase activity
CH48_RS11700	COG0577	efflux transmembrane transporter activity
CH48_RS11700	COG1136	(ABC) transporter
CH48_RS11715	COG2801	Transposase and inactivated derivatives
CH48_RS11730	COG1120	ATPase activity
CH48_RS11735	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CH48_RS11740	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CH48_RS11745	COG4592	Periplasmic binding protein
CH48_RS11750	COG2271	Major facilitator Superfamily
CH48_RS11755	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CH48_RS11760	COG0840	transmembrane signaling receptor activity
CH48_RS11775	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CH48_RS11785	COG1987	bacterial-type flagellum assembly
CH48_RS11810	COG1677	Flagellar hook-basal body complex protein FliE
CH48_RS11860	COG1815	bacterial-type flagellum-dependent cell motility
CH48_RS11865	COG1558	bacterial-type flagellum-dependent cell motility
CH48_RS11870	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CH48_RS11885	COG4786	Flagellar basal body rod
CH48_RS11895	COG1706	bacterial-type flagellum-dependent cell motility
CH48_RS11925	COG3710	Transcriptional regulator
CH48_RS11930	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CH48_RS11935	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CH48_RS11940	COG1516	flagellar protein fliS
CH48_RS11960	COG1191	sigma factor activity
CH48_RS11965	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CH48_RS11975	COG3133	Outer membrane lipoprotein
CH48_RS11980	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
CH48_RS11985	COG0437	4 iron, 4 sulfur cluster binding
CH48_RS11990	COG5557	Pfam Polysulphide reductase, NrfD
CH48_RS11995	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
CH48_RS12000	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
CH48_RS12005	COG1773	rubredoxin
CH48_RS12015	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CH48_RS12020	COG0298	carbon dioxide binding
CH48_RS12025	COG0409	Hydrogenase expression formation protein
CH48_RS12030	COG0309	Hydrogenase expression formation protein (HypE)
CH48_RS12035	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
CH48_RS12045	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
CH48_RS12055	COG5001	Diguanylate cyclase
CH48_RS12075	COG0477	Major facilitator Superfamily
CH48_RS12090	COG1283	sodium-dependent phosphate transmembrane transporter activity
CH48_RS12100	COG1609	Transcriptional regulator
CH48_RS12105	COG0477	Major facilitator Superfamily
CH48_RS12120	COG0697	spore germination
CH48_RS12135	COG4607	ABC-type enterochelin transport system periplasmic component
CH48_RS12145	COG4605	iron ion homeostasis
CH48_RS12150	COG4604	ABC transporter, ATP-binding protein
CH48_RS12155	COG0024	Methionine aminopeptidase
CH48_RS12180	COG1289	transmembrane transporter activity
CH48_RS12190	COG1982	Orn Lys Arg decarboxylase major
CH48_RS12195	COG0531	amino acid
CH48_RS12235	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
CH48_RS12250	COG1982	Orn Lys Arg decarboxylase major
CH48_RS12260	COG0741	lytic transglycosylase activity
CH48_RS12265	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
CH48_RS12270	COG1194	a g-specific adenine glycosylase
CH48_RS12275	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CH48_RS12280	COG3171	Protein conserved in bacteria
CH48_RS12295	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CH48_RS12300	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CH48_RS12305	COG1872	DUF167
CH48_RS12310	COG0762	integral membrane protein
CH48_RS12315	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CH48_RS12320	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CH48_RS12325	COG2805	Type II/IV secretion system protein
CH48_RS12335	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CH48_RS12340	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CH48_RS12345	COG1678	Uncharacterized ACR, COG1678
CH48_RS12350	COG0189	ligase activity
CH48_RS12355	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CH48_RS12360	COG2356	endonuclease I
CH48_RS12365	COG3091	SprT-like family
CH48_RS12370	COG0640	Transcriptional regulator
CH48_RS12385	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CH48_RS12390	COG1166	arginine decarboxylase activity
CH48_RS12400	COG0501	Belongs to the peptidase M48B family
CH48_RS12405	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CH48_RS12410	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CH48_RS12415	COG0126	phosphoglycerate kinase activity
CH48_RS12420	COG0191	fructose-bisphosphate aldolase activity
CH48_RS12440	COG1279	arginine transmembrane transporter activity
CH48_RS12450	COG0583	DNA-binding transcription factor activity
CH48_RS12455	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CH48_RS12460	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CH48_RS12495	COG0602	queuosine metabolic process
CH48_RS12520	COG0720	synthase
CH48_RS12525	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CH48_RS12530	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CH48_RS12535	COG0175	sulfate reduction
CH48_RS12550	COG2234	aminopeptidase activity
CH48_RS12555	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CH48_RS12555	COG1648	precorrin-2 dehydrogenase activity
CH48_RS12560	COG0175	sulfate reduction
CH48_RS12565	COG2895	sulfate adenylyltransferase (ATP) activity
CH48_RS12570	COG0529	Catalyzes the synthesis of activated sulfate
CH48_RS12580	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
CH48_RS12590	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CH48_RS12595	COG0585	pseudouridine synthase activity
CH48_RS12600	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CH48_RS12605	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CH48_RS12610	COG4942	peptidase
CH48_RS12610	COG1388	LysM domain
CH48_RS12615	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CH48_RS12620	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CH48_RS12650	COG3121	Chaperone
CH48_RS12660	COG3539	Fimbrial protein
CH48_RS12665	COG3539	Fimbrial protein
CH48_RS12695	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CH48_RS12705	COG1538	Outer membrane efflux protein
CH48_RS12725	COG1028	Short-chain dehydrogenase reductase Sdr
CH48_RS12735	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CH48_RS12740	COG1858	cytochrome C peroxidase
CH48_RS12750	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CH48_RS12755	COG0640	Transcriptional regulator
CH48_RS12810	COG0410	ABC transporter
CH48_RS12815	COG1137	ATPase activity
CH48_RS12820	COG4177	L-phenylalanine transmembrane transporter activity
CH48_RS12835	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
CH48_RS12835	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
CH48_RS12840	COG0243	molybdopterin cofactor binding
CH48_RS12845	COG0437	4 iron, 4 sulfur cluster binding
CH48_RS12850	COG3302	dmso reductase anchor subunit
CH48_RS12855	COG3381	protein complex oligomerization
CH48_RS12875	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CH48_RS12880	COG2137	regulation of response to DNA damage stimulus
CH48_RS12885	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CH48_RS12890	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
CH48_RS12915	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CH48_RS12920	COG1238	metal cluster binding
CH48_RS12925	COG2918	glutathione biosynthetic process
CH48_RS12930	COG1854	S-ribosylhomocysteine lyase activity
CH48_RS12940	COG4536	flavin adenine dinucleotide binding
CH48_RS12945	COG4137	Cytochrome C assembly protein
CH48_RS12950	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CH48_RS12955	COG0228	four-way junction DNA binding
CH48_RS12960	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CH48_RS12965	COG0336	Belongs to the RNA methyltransferase TrmD family
CH48_RS12970	COG0335	large ribosomal subunit rRNA binding
CH48_RS12975	COG3137	Salt-induced outer membrane protein
CH48_RS12980	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CH48_RS12985	COG3279	Response regulator of the LytR AlgR family
CH48_RS12990	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CH48_RS12995	COG1605	Chorismate mutase
CH48_RS12995	COG0287	Prephenate dehydrogenase
CH48_RS13000	COG0077	Prephenate dehydratase
CH48_RS13000	COG1605	Chorismate mutase
CH48_RS13015	COG0542	response to heat
CH48_RS13025	COG0564	pseudouridine synthase activity
CH48_RS13030	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CH48_RS13035	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CH48_RS13065	COG5544	Lipoprotein
CH48_RS13070	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CH48_RS13075	COG1042	CoA-binding domain protein
CH48_RS13075	COG0045	succinate-CoA ligase (ADP-forming) activity
CH48_RS13075	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CH48_RS13080	COG3148	PFAM DTW domain containing protein
CH48_RS13085	COG3118	belongs to the thioredoxin family
CH48_RS13090	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CH48_RS13105	COG2814	Major facilitator Superfamily
CH48_RS13110	COG1566	PFAM secretion protein HlyD family protein
CH48_RS13115	COG1538	Outer membrane efflux protein
CH48_RS13120	COG1846	Transcriptional regulator
CH48_RS13130	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
CH48_RS13135	COG2814	Major facilitator Superfamily
CH48_RS13175	COG0765	amino acid transport
CH48_RS13180	COG0765	amino acid transport
CH48_RS13190	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CH48_RS13205	COG0436	Aminotransferase
CH48_RS13210	COG0235	Class ii aldolase
CH48_RS13215	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
CH48_RS13220	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
CH48_RS13225	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
CH48_RS13230	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
CH48_RS13245	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
CH48_RS13250	COG1960	acyl-CoA dehydrogenase activity
CH48_RS13260	COG0121	glutamine amidotransferase
CH48_RS13265	COG3034	peptidoglycan biosynthetic process
CH48_RS13270	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CH48_RS13275	COG1805	sodium ion transport
CH48_RS13280	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CH48_RS13285	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CH48_RS13290	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CH48_RS13295	COG2871	sodium ion transport
CH48_RS13300	COG1477	protein flavinylation
CH48_RS13305	COG2991	Protein conserved in bacteria
CH48_RS13315	COG1181	Belongs to the D-alanine--D-alanine ligase family
CH48_RS13320	COG2964	Protein conserved in bacteria
CH48_RS13335	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CH48_RS13340	COG2195	Cleaves the N-terminal amino acid of tripeptides
CH48_RS13345	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
CH48_RS13350	COG1073	alpha beta
CH48_RS13360	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CH48_RS13365	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CH48_RS13370	COG2188	Transcriptional regulator
CH48_RS13390	COG3459	Glycosyltransferase 36 associated
CH48_RS13405	COG2226	methyltransferase
CH48_RS13430	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CH48_RS13435	COG3123	guanosine phosphorylase activity
CH48_RS13440	COG2974	May be involved in recombination
CH48_RS13445	COG1940	carbohydrate kinase activity
CH48_RS13450	COG0419	ATPase involved in DNA repair
CH48_RS13455	COG0420	3'-5' exonuclease activity
CH48_RS13460	COG0745	RESPONSE REGULATOR receiver
CH48_RS13465	COG5002	protein histidine kinase activity
CH48_RS13485	COG0366	Alpha amylase catalytic
CH48_RS13505	COG0450	alkyl hydroperoxide reductase
CH48_RS13510	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
CH48_RS13515	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CH48_RS13530	COG0343	queuine tRNA-ribosyltransferase activity
CH48_RS13535	COG1862	Preprotein translocase
CH48_RS13540	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CH48_RS13545	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CH48_RS13565	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CH48_RS13570	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CH48_RS13570	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CH48_RS13575	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CH48_RS13580	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CH48_RS13585	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CH48_RS13590	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CH48_RS13600	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CH48_RS13605	COG0142	geranyltranstransferase activity
CH48_RS13615	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CH48_RS13615	COG0301	tRNA thio-modification
CH48_RS13625	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CH48_RS13630	COG1666	GTP binding
CH48_RS13635	COG2814	Major facilitator Superfamily
CH48_RS13640	COG0109	protoheme IX farnesyltransferase activity
CH48_RS13645	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
CH48_RS13650	COG1845	cytochrome c oxidase, subunit III
CH48_RS13655	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CH48_RS13660	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CH48_RS13670	COG2223	nitrite transmembrane transporter activity
CH48_RS13675	COG3056	Lipoprotein
CH48_RS13680	COG0271	Belongs to the BolA IbaG family
CH48_RS13690	COG0544	peptidyl-prolyl cis-trans isomerase activity
CH48_RS13695	COG0740	serine-type endopeptidase activity
CH48_RS13700	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CH48_RS13705	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CH48_RS13710	COG0776	regulation of translation
CH48_RS13715	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CH48_RS13720	COG1555	photosystem II stabilization
CH48_RS13725	COG0824	Thioesterase
CH48_RS13730	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CH48_RS13735	COG4533	DNA binding
CH48_RS13740	COG0561	phosphatase activity
CH48_RS13750	COG1522	sequence-specific DNA binding
CH48_RS13755	COG1132	(ABC) transporter
CH48_RS13760	COG1132	(ABC) transporter
CH48_RS13765	COG0347	Belongs to the P(II) protein family
CH48_RS13770	COG0004	ammonium transporteR
CH48_RS13775	COG1946	Acyl-CoA thioesterase
CH48_RS13780	COG3126	Type III secretion system lipoprotein chaperone (YscW)
CH48_RS13785	COG3695	enzyme binding
CH48_RS13810	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CH48_RS13815	COG0803	Belongs to the bacterial solute-binding protein 9 family
CH48_RS13820	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CH48_RS13825	COG0254	rRNA binding
CH48_RS13840	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
CH48_RS13845	COG3457	Alanine racemase
CH48_RS13855	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CH48_RS13860	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CH48_RS13865	COG1309	transcriptional regulator
CH48_RS13870	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
CH48_RS13875	COG1196	nuclear chromosome segregation
CH48_RS13875	COG3264	Mechanosensitive ion channel
CH48_RS13890	COG2832	Protein of unknown function (DUF454)
CH48_RS13895	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CH48_RS13905	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CH48_RS13910	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CH48_RS13915	COG0326	Molecular chaperone. Has ATPase activity
CH48_RS13920	COG0563	adenylate kinase activity
CH48_RS13925	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CH48_RS13930	COG2244	polysaccharide biosynthetic process
CH48_RS13935	COG1442	glycosyl transferase family 8
CH48_RS13935	COG1216	Glycosyl transferase, family 2
CH48_RS13940	COG1215	transferase activity, transferring glycosyl groups
CH48_RS13945	COG0438	transferase activity, transferring glycosyl groups
CH48_RS13950	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CH48_RS13955	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CH48_RS13975	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CH48_RS13980	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CH48_RS13980	COG4651	solute:proton antiporter activity
CH48_RS13985	COG2223	nitrite transmembrane transporter activity
CH48_RS13990	COG0737	Belongs to the 5'-nucleotidase family
CH48_RS14000	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CH48_RS14005	COG3735	TraB family
CH48_RS14010	COG2217	Heavy metal translocating P-type atpase
CH48_RS14015	COG0789	Transcriptional regulator
CH48_RS14020	COG1585	Membrane protein implicated in regulation of membrane protease activity
CH48_RS14025	COG0330	HflC and HflK could
CH48_RS14030	COG3118	belongs to the thioredoxin family
CH48_RS14035	COG0300	oxidoreductase activity
CH48_RS14040	COG2755	lipolytic protein G-D-S-L family
CH48_RS14045	COG4181	ATPase activity
CH48_RS14050	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
CH48_RS14055	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CH48_RS14060	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CH48_RS14065	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CH48_RS14070	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CH48_RS14075	COG0215	cysteine-tRNA ligase activity
CH48_RS14080	COG2501	S4 domain
CH48_RS14085	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CH48_RS14095	COG0582	viral genome integration into host DNA
CH48_RS14140	COG2850	peptidyl-arginine hydroxylation
CH48_RS14145	COG2986	histidine ammonia-lyase
CH48_RS14155	COG5265	(ABC) transporter
CH48_RS14170	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CH48_RS14180	COG2197	response regulator
CH48_RS14185	COG1278	Cold shock
CH48_RS14200	COG3706	GGDEF domain
CH48_RS14205	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CH48_RS14210	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CH48_RS14215	COG0321	lipoyl(octanoyl) transferase activity
CH48_RS14220	COG2921	Belongs to the UPF0250 family
CH48_RS14225	COG1686	Belongs to the peptidase S11 family
CH48_RS14230	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CH48_RS14235	COG0772	Belongs to the SEDS family
CH48_RS14240	COG0768	penicillin binding
CH48_RS14250	COG0799	negative regulation of ribosome biogenesis
CH48_RS14255	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CH48_RS14260	COG1466	dna polymerase III delta subunit
CH48_RS14265	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
CH48_RS14270	COG0495	leucyl-tRNA aminoacylation
CH48_RS14275	COG2888	peptidyl-tyrosine sulfation
CH48_RS14280	COG1126	abc transporter atp-binding protein
CH48_RS14285	COG0765	amino acid transport
CH48_RS14290	COG0765	amino acid transport
CH48_RS14305	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CH48_RS14310	COG4535	Mg2 and Co2 transporter CorC
CH48_RS14315	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CH48_RS14320	COG1702	phosphate starvation-inducible protein PhoH
CH48_RS14325	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CH48_RS14330	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CH48_RS14365	COG0367	asparagine synthase
CH48_RS14370	COG0647	UMP catabolic process
CH48_RS14375	COG1846	Transcriptional regulator
CH48_RS14375	COG1940	carbohydrate kinase activity
CH48_RS14380	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CH48_RS14385	COG0363	glucosamine-6-phosphate deaminase activity
CH48_RS14390	COG1263	PTS System
CH48_RS14390	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CH48_RS14390	COG2190	(PTS) system
CH48_RS14395	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CH48_RS14415	COG0735	belongs to the Fur family
CH48_RS14425	COG0840	transmembrane signaling receptor activity
CH48_RS14435	COG0596	Alpha beta hydrolase
CH48_RS14440	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
CH48_RS14445	COG0033	Phosphoglucomutase
CH48_RS14460	COG0745	RESPONSE REGULATOR receiver
CH48_RS14465	COG2205	protein histidine kinase activity
CH48_RS14470	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
CH48_RS14475	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
CH48_RS14480	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
CH48_RS14500	COG2994	toxin metabolic process
CH48_RS14505	COG3064	Membrane
CH48_RS14505	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
CH48_RS14505	COG1073	alpha beta
CH48_RS14505	COG3064	Membrane
CH48_RS14505	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
CH48_RS14505	COG1073	alpha beta
CH48_RS14510	COG3272	Protein of unknown function (DUF1722)
CH48_RS14520	COG5212	phosphodiesterase
CH48_RS14525	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CH48_RS14530	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CH48_RS14535	COG1984	allophanate hydrolase subunit 2
CH48_RS14540	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CH48_RS14555	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
CH48_RS14565	COG2009	succinate dehydrogenase
CH48_RS14570	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
CH48_RS14575	COG1053	succinate dehydrogenase
CH48_RS14585	COG0567	Dehydrogenase, E1 component
CH48_RS14590	COG0508	dehydrogenase complex catalyzes the overall conversion of
CH48_RS14595	COG0045	succinate-CoA ligase (ADP-forming) activity
CH48_RS14600	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CH48_RS14610	COG0737	Belongs to the 5'-nucleotidase family
CH48_RS14615	COG1271	oxidase subunit
CH48_RS14620	COG1294	oxidase, subunit
CH48_RS14625	COG4890	Cyd operon protein YbgT
CH48_RS14630	COG3790	cyd operon protein YbgE
CH48_RS14635	COG0824	Thioesterase
CH48_RS14640	COG0811	peptide transport
CH48_RS14645	COG0848	biopolymer transport protein
CH48_RS14650	COG3064	Membrane
CH48_RS14650	COG3064	Membrane
CH48_RS14655	COG0823	Involved in the tonB-independent uptake of proteins
CH48_RS14660	COG2885	chlorophyll binding
CH48_RS14665	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
CH48_RS14690	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CH48_RS14700	COG1230	cation diffusion facilitator family transporter
CH48_RS14705	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CH48_RS14710	COG0588	phosphoglycerate mutase activity
CH48_RS14735	COG2017	converts alpha-aldose to the beta-anomer
CH48_RS14740	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CH48_RS14745	COG1085	galactose-1-phosphate uridylyltransferase
CH48_RS14750	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CH48_RS14760	COG1119	ATPase activity
CH48_RS14765	COG2005	Transcriptional regulator
CH48_RS14765	COG3585	molybdate ion transport
CH48_RS14775	COG0725	ABC transporter, periplasmic molybdate-binding protein
CH48_RS14780	COG0582	viral genome integration into host DNA
CH48_RS14960	COG3772	lysozyme
CH48_RS14970	COG4149	molybdate abc transporter
CH48_RS14980	COG0561	phosphatase activity
CH48_RS14985	COG2706	6-phosphogluconolactonase activity
CH48_RS14995	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CH48_RS15000	COG0156	8-amino-7-oxononanoate synthase activity
CH48_RS15005	COG2226	methyltransferase
CH48_RS15020	COG0556	nucleotide-excision repair
CH48_RS15025	COG4628	conserved protein (DUF2132)
CH48_RS15030	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CH48_RS15035	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CH48_RS15040	COG0315	cyclic pyranopterin monophosphate synthase activity
CH48_RS15045	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
CH48_RS15050	COG0314	molybdopterin synthase activity
CH48_RS15055	COG0670	Belongs to the BI1 family
CH48_RS15060	COG0842	Transport permease protein
CH48_RS15065	COG0842	Transport permease protein
CH48_RS15070	COG1131	(ABC) transporter
CH48_RS15075	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CH48_RS15080	COG1309	transcriptional regulator
CH48_RS15085	COG0513	Belongs to the DEAD box helicase family
CH48_RS15090	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CH48_RS15100	COG2239	Acts as a magnesium transporter
CH48_RS15110	COG1686	Belongs to the peptidase S11 family
CH48_RS15115	COG0277	FAD linked oxidase domain protein
CH48_RS15135	COG2261	transglycosylase associated protein
CH48_RS15145	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
CH48_RS15160	COG4807	Protein conserved in bacteria
CH48_RS15180	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
CH48_RS15190	COG2897	thiosulfate sulfurtransferase activity
CH48_RS15205	COG1732	Glycine betaine
CH48_RS15210	COG1174	glycine betaine transport
CH48_RS15215	COG1125	glycine betaine transport
CH48_RS15220	COG1174	glycine betaine transport
CH48_RS15230	COG1028	Short-chain dehydrogenase reductase Sdr
CH48_RS15235	COG0583	DNA-binding transcription factor activity
CH48_RS15245	COG0697	spore germination
CH48_RS15265	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CH48_RS15270	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CH48_RS15290	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
CH48_RS15300	COG1126	abc transporter atp-binding protein
CH48_RS15305	COG0765	amino acid transport
CH48_RS15310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CH48_RS15315	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CH48_RS15320	COG0783	Belongs to the Dps family
CH48_RS15325	COG4106	trans-aconitate 2-methyltransferase activity
CH48_RS15340	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
CH48_RS15360	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
CH48_RS15380	COG0488	(ABC) transporter
CH48_RS15390	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CH48_RS15395	COG0303	'Molybdopterin
CH48_RS15410	COG0577	efflux transmembrane transporter activity
CH48_RS15410	COG1136	(ABC) transporter
CH48_RS15440	COG0583	DNA-binding transcription factor activity
CH48_RS15445	COG0477	Major facilitator Superfamily
CH48_RS15450	COG0302	gtp cyclohydrolase
CH48_RS15455	COG2311	Membrane
CH48_RS15480	COG3604	Transcriptional regulator
CH48_RS15485	COG3383	formate dehydrogenase (NAD+) activity
CH48_RS15490	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CH48_RS15495	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
CH48_RS15505	COG3260	NADH ubiquinone oxidoreductase 20
CH48_RS15510	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CH48_RS15515	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
CH48_RS15515	COG3261	NADH dehydrogenase
CH48_RS15520	COG0651	ATP synthesis coupled electron transport
CH48_RS15525	COG4237	Hydrogenase 4 membrane
CH48_RS15530	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CH48_RS15535	COG0650	Formate hydrogenlyase subunit 4
CH48_RS15540	COG0651	ATP synthesis coupled electron transport
CH48_RS15545	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CH48_RS15550	COG0375	protein maturation
CH48_RS15555	COG0298	carbon dioxide binding
CH48_RS15560	COG2949	membrane
CH48_RS15565	COG0281	malic enzyme
CH48_RS15580	COG1346	cytolysis
CH48_RS15585	COG1380	Effector of murein hydrolase LrgA
CH48_RS15590	COG2814	Major facilitator Superfamily
CH48_RS15610	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CH48_RS15610	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CH48_RS15615	COG0489	protein tyrosine kinase activity
CH48_RS15620	COG0572	uridine kinase
CH48_RS15630	COG2982	Protein involved in outer membrane biogenesis
CH48_RS15635	COG3069	C4-dicarboxylate transmembrane transporter activity
CH48_RS15640	COG1253	flavin adenine dinucleotide binding
CH48_RS15655	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CH48_RS15660	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CH48_RS15665	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
CH48_RS15670	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CH48_RS15695	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CH48_RS15705	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CH48_RS15710	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CH48_RS15710	COG0140	phosphoribosyl-ATP diphosphatase activity
CH48_RS15715	COG0107	imidazoleglycerol-phosphate synthase activity
CH48_RS15720	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CH48_RS15730	COG0131	Imidazoleglycerol-phosphate dehydratase
CH48_RS15730	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CH48_RS15735	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CH48_RS15745	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CH48_RS15750	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CH48_RS15760	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH48_RS15765	COG1129	ABC transporter
CH48_RS15780	COG0531	amino acid
CH48_RS15785	COG2925	Exonuclease
CH48_RS15790	COG3320	Male sterility
CH48_RS15790	COG1022	Amp-dependent synthetase and ligase
CH48_RS15795	COG1289	transmembrane transporter activity
CH48_RS15800	COG2926	Belongs to the UPF0265 family
CH48_RS15810	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH48_RS15815	COG1129	ABC transporter
CH48_RS15830	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CH48_RS15840	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CH48_RS15860	COG4656	Part of a membrane complex involved in electron transport
CH48_RS15870	COG1012	belongs to the aldehyde dehydrogenase family
CH48_RS15880	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
CH48_RS15955	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
CH48_RS15965	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
CH48_RS16030	COG1492	cobalamin metabolic process
CH48_RS16050	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CH48_RS16120	COG3121	Chaperone
CH48_RS16125	COG3188	usher protein
CH48_RS16195	COG0137	argininosuccinate synthase activity
CH48_RS16200	COG0534	Mate efflux family protein
CH48_RS16210	COG0352	thiamine-phosphate diphosphorylase activity
CH48_RS16215	COG0561	phosphatase activity
CH48_RS16220	COG1349	DNA-binding transcription factor activity
CH48_RS16230	COG0784	Response regulator, receiver
CH48_RS16230	COG0835	chemotaxis
CH48_RS16260	COG3842	ATPase activity
CH48_RS16270	COG1840	ABC-type Fe3 transport system, periplasmic component
CH48_RS16275	COG2271	Major facilitator Superfamily
CH48_RS16290	COG4565	transcriptional regulatory protein
CH48_RS16295	COG3290	protein histidine kinase activity
CH48_RS16305	COG3052	prosthetic group binding
CH48_RS16310	COG2301	Belongs to the HpcH HpaI aldolase family
CH48_RS16315	COG3051	citrate lyase alpha subunit
CH48_RS16320	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
CH48_RS16320	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
CH48_RS16330	COG0471	metal ion transport
CH48_RS16345	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CH48_RS16365	COG2814	Major facilitator Superfamily
CH48_RS16370	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH48_RS16370	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH48_RS16375	COG3122	Protein conserved in bacteria
CH48_RS16395	COG3121	Chaperone
CH48_RS16420	COG2205	protein histidine kinase activity
CH48_RS16420	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CH48_RS16435	COG3228	Belongs to the MtfA family
CH48_RS16445	COG1070	Carbohydrate kinase
CH48_RS16470	COG3121	Chaperone
CH48_RS16510	COG1028	Short-chain dehydrogenase reductase Sdr
CH48_RS16510	COG3321	synthase
CH48_RS16510	COG0604	alcohol dehydrogenase
CH48_RS16520	COG3250	beta-galactosidase activity
CH48_RS16525	COG1609	Transcriptional regulator
CH48_RS16540	COG0840	transmembrane signaling receptor activity
CH48_RS16555	COG1285	pathogenesis
CH48_RS16565	COG2130	NADP-dependent
CH48_RS16570	COG0589	response to stress
CH48_RS16590	COG1360	Flagellar Motor Protein
CH48_RS16595	COG0643	Histidine kinase
CH48_RS16595	COG2198	Histidine kinase
CH48_RS16600	COG0835	chemotaxis
CH48_RS16605	COG0840	transmembrane signaling receptor activity
CH48_RS16610	COG0840	transmembrane signaling receptor activity
CH48_RS16615	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CH48_RS16625	COG0745	RESPONSE REGULATOR receiver
CH48_RS16630	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
CH48_RS16635	COG4935	Belongs to the peptidase S8 family
CH48_RS16635	COG1404	Belongs to the peptidase S8 family
CH48_RS16640	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CH48_RS16645	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CH48_RS16660	COG3418	PFAM FlgN family protein
CH48_RS16665	COG2747	anti-sigma28 factor FlgM
CH48_RS16675	COG1815	bacterial-type flagellum-dependent cell motility
CH48_RS16680	COG1558	bacterial-type flagellum-dependent cell motility
CH48_RS16685	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CH48_RS16720	COG1256	bacterial-type flagellum assembly
CH48_RS16740	COG1338	Plays a role in the flagellum-specific transport system
CH48_RS16760	COG1580	Controls the rotational direction of flagella during chemotaxis
CH48_RS16780	COG1317	bacterial-type flagellum organization
CH48_RS16795	COG1677	Flagellar hook-basal body complex protein FliE
CH48_RS16830	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
CH48_RS16835	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CH48_RS16880	COG1191	sigma factor activity
CH48_RS16890	COG2515	1-aminocyclopropane-1-carboxylate deaminase
CH48_RS16895	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CH48_RS16900	COG0765	amino acid transport
CH48_RS16905	COG1126	abc transporter atp-binding protein
CH48_RS16920	COG0506	proline dehydrogenase activity
CH48_RS16920	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CH48_RS16920	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CH48_RS16935	COG3157	Type VI secretion system effector, Hcp
CH48_RS16945	COG0672	)-iron permease
CH48_RS16950	COG2822	iron ion transport
CH48_RS16960	COG0655	NAD(P)H dehydrogenase (quinone) activity
CH48_RS16970	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
CH48_RS16985	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CH48_RS16990	COG0778	Nitroreductase
CH48_RS16995	COG2267	carboxylic ester hydrolase activity
CH48_RS17000	COG0251	oxidation-reduction process
CH48_RS17005	COG1335	isochorismatase
CH48_RS17010	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CH48_RS17015	COG1309	transcriptional regulator
CH48_RS17020	COG1113	amino acid transport
CH48_RS17030	COG0582	viral genome integration into host DNA
CH48_RS17035	COG2963	transposase activity
CH48_RS17045	COG2226	methyltransferase
CH48_RS17060	COG0366	Alpha amylase catalytic
CH48_RS17070	COG3136	membrane protein required for alginate biosynthesis
CH48_RS17080	COG2197	response regulator
CH48_RS17085	COG0322	excinuclease ABC activity
CH48_RS17090	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CH48_RS17175	COG3077	Addiction module antitoxin, RelB DinJ family
CH48_RS17180	COG3041	Addiction module toxin RelE StbE family
CH48_RS17270	COG2963	transposase activity
CH48_RS17280	COG3328	transposase activity
CH48_RS17325	COG3772	lysozyme
CH48_RS17330	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
CH48_RS17335	COG2979	Protein of unknown function (DUF533)
CH48_RS17350	COG0012	GTP binding
CH48_RS17360	COG0193	aminoacyl-tRNA hydrolase activity
CH48_RS17375	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CH48_RS17385	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
CH48_RS17390	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CH48_RS17395	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CH48_RS17400	COG2890	protein-(glutamine-N5) methyltransferase activity
CH48_RS17415	COG2877	3-deoxy-8-phosphooctulonate synthase activity
CH48_RS17425	COG3706	GGDEF domain
CH48_RS17445	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CH48_RS17450	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CH48_RS17455	COG3381	protein complex oligomerization
CH48_RS17465	COG0477	Major facilitator Superfamily
CH48_RS17480	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CH48_RS17490	COG0673	inositol 2-dehydrogenase activity
CH48_RS17495	COG0728	peptidoglycan biosynthetic process
CH48_RS17500	COG0387	Pfam Sodium calcium exchanger
CH48_RS17515	COG0583	DNA-binding transcription factor activity
CH48_RS17520	COG3850	Histidine kinase
CH48_RS17525	COG1294	oxidase, subunit
CH48_RS17530	COG1271	oxidase subunit
CH48_RS17535	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CH48_RS17540	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CH48_RS17545	COG3138	arginine N-succinyltransferase
CH48_RS17555	COG3724	N-succinylarginine dihydrolase activity
CH48_RS17560	COG2988	succinylglutamate desuccinylase activity
CH48_RS17590	COG1228	amidohydrolase
CH48_RS17600	COG0402	S-adenosylhomocysteine deaminase activity
CH48_RS17610	COG3443	Belongs to the bacterial solute-binding protein 9 family
CH48_RS17635	COG4942	peptidase
CH48_RS17645	COG2222	sugar isomerase
CH48_RS17650	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH48_RS17655	COG3716	PTS system mannose fructose sorbose family IID component
CH48_RS17665	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CH48_RS17675	COG1349	DNA-binding transcription factor activity
CH48_RS17695	COG1187	pseudouridine synthase activity
CH48_RS17700	COG0786	glutamate:sodium symporter activity
CH48_RS17720	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CH48_RS17725	COG2226	methyltransferase
CH48_RS17730	COG3788	relative of glutathione S-transferase, MAPEG superfamily
CH48_RS17735	COG1801	Protein of unknown function DUF72
CH48_RS17740	COG1335	isochorismatase
CH48_RS17750	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CH48_RS17755	COG0494	nUDIX hydrolase
CH48_RS17760	COG0217	transcriptional regulatory protein
CH48_RS17765	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CH48_RS17770	COG0632	four-way junction helicase activity
CH48_RS17775	COG2255	four-way junction helicase activity
CH48_RS17780	COG3104	oligopeptide transport
CH48_RS17785	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CH48_RS17790	COG1121	(ABC) transporter
CH48_RS17795	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
CH48_RS17800	COG0739	heme binding
CH48_RS17805	COG1560	Kdo2-lipid A biosynthetic process
CH48_RS17815	COG3328	transposase activity
CH48_RS17820	COG0469	pyruvate kinase activity
CH48_RS17825	COG1737	Transcriptional regulator
CH48_RS17830	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CH48_RS17835	COG0800	Aldolase
CH48_RS17840	COG2076	Multidrug Resistance protein
CH48_RS17845	COG2076	Multidrug Resistance protein
CH48_RS17850	COG0251	oxidation-reduction process
CH48_RS17855	COG1199	ATP-dependent helicase activity
CH48_RS17865	COG3065	identical protein binding
CH48_RS17870	COG0318	PFAM AMP-dependent synthetase and ligase
CH48_RS17875	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
CH48_RS17880	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
CH48_RS17885	COG2894	cell division
CH48_RS17890	COG0850	regulation of cytokinetic process
CH48_RS17900	COG3100	YcgL domain-containing protein
CH48_RS17905	COG2951	lytic endotransglycosylase activity
CH48_RS17910	COG0179	Fumarylacetoacetate (FAA) hydrolase
CH48_RS17915	COG2983	Belongs to the UPF0260 family
CH48_RS17940	COG0668	transmembrane transport
CH48_RS17945	COG0625	glutathione transferase activity
CH48_RS17970	COG5001	Diguanylate cyclase
CH48_RS17970	COG4251	negative regulation of phosphorylation
CH48_RS17970	COG3706	GGDEF domain
CH48_RS17970	COG2203	Gaf domain
CH48_RS18005	COG2814	Major facilitator Superfamily
CH48_RS18015	COG3008	intermembrane lipid transfer
CH48_RS18020	COG2995	paraquat-inducible protein a
CH48_RS18025	COG1956	GAF domain-containing protein
CH48_RS18035	COG0793	Belongs to the peptidase S41A family
CH48_RS18040	COG0501	Belongs to the peptidase M48B family
CH48_RS18050	COG2814	Major facilitator Superfamily
CH48_RS18055	COG0823	Involved in the tonB-independent uptake of proteins
CH48_RS18065	COG3023	N-Acetylmuramoyl-L-alanine amidase
CH48_RS18070	COG1823	symporter activity
CH48_RS18075	COG1988	membrane-bound metal-dependent
CH48_RS18085	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CH48_RS18090	COG1653	transport
CH48_RS18095	COG3842	ATPase activity
CH48_RS18100	COG0395	ABC-type sugar transport system, permease component
CH48_RS18105	COG1175	transmembrane transport
CH48_RS18115	COG1028	Short-chain dehydrogenase reductase Sdr
CH48_RS18120	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
CH48_RS18125	COG1917	Cupin 2, conserved barrel domain protein
CH48_RS18130	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CH48_RS18140	COG0583	DNA-binding transcription factor activity
CH48_RS18145	COG0427	acetyl-CoA hydrolase
CH48_RS18150	COG1024	Enoyl-CoA hydratase
CH48_RS18155	COG1703	isobutyryl-CoA mutase activity
CH48_RS18160	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CH48_RS18160	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CH48_RS18165	COG3001	Fructosamine kinase
CH48_RS18170	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CH48_RS18175	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CH48_RS18180	COG1121	(ABC) transporter
CH48_RS18185	COG0803	Belongs to the bacterial solute-binding protein 9 family
CH48_RS18220	COG1811	Na channel or pump
CH48_RS18225	COG4249	Peptidase C14 caspase catalytic subunit p20
CH48_RS18230	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CH48_RS18235	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CH48_RS18240	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CH48_RS18245	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CH48_RS18250	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CH48_RS18260	COG0776	regulation of translation
CH48_RS18265	COG2314	TM2 domain
CH48_RS18275	COG4139	cobalamin transport
CH48_RS18280	COG0386	Belongs to the glutathione peroxidase family
CH48_RS18285	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
CH48_RS18290	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CH48_RS18295	COG0463	Glycosyl transferase, family 2
CH48_RS18300	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CH48_RS18300	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CH48_RS18305	COG0726	polysaccharide deacetylase
CH48_RS18310	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CH48_RS18315	COG2076	Multidrug Resistance protein
CH48_RS18320	COG2076	Multidrug Resistance protein
CH48_RS18325	COG0791	NLP P60 protein
CH48_RS18330	COG0095	Lipoate-protein ligase
CH48_RS18340	COG4558	Periplasmic binding protein
CH48_RS18345	COG3720	iron ion transport
CH48_RS18365	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CH48_RS18375	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CH48_RS18375	COG0574	Belongs to the PEP-utilizing enzyme family
CH48_RS18380	COG0628	permease
CH48_RS18385	COG0277	FAD linked oxidase domain protein
CH48_RS18385	COG0247	lactate metabolic process
CH48_RS18395	COG2050	protein possibly involved in aromatic compounds catabolism
CH48_RS18400	COG0316	Belongs to the HesB IscA family
CH48_RS18405	COG0719	Fe-S assembly protein
CH48_RS18410	COG0396	ATPase activity
CH48_RS18415	COG0719	Fe-S assembly protein
CH48_RS18425	COG2166	iron-sulfur cluster assembly
CH48_RS18430	COG1376	ErfK ybiS ycfS ynhG family protein
CH48_RS18430	COG1388	LysM domain
CH48_RS18460	COG0534	Mate efflux family protein
CH48_RS18465	COG0307	riboflavin synthase, alpha
CH48_RS18470	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CH48_RS18475	COG2814	Major facilitator Superfamily
CH48_RS18480	COG0583	DNA-binding transcription factor activity
CH48_RS18485	COG1609	Transcriptional regulator
CH48_RS18495	COG0791	NLP P60 protein
CH48_RS18500	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CH48_RS18505	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CH48_RS18510	COG0346	lactoylglutathione lyase activity
CH48_RS18515	COG1902	pentaerythritol trinitrate reductase activity
CH48_RS18520	COG1309	transcriptional regulator
CH48_RS18525	COG2194	sulfuric ester hydrolase activity
CH48_RS18530	COG3313	Fe-S protein
CH48_RS18535	COG4989	oxidoreductase activity
CH48_RS18540	COG1289	transmembrane transporter activity
CH48_RS18545	COG1566	PFAM secretion protein HlyD family protein
CH48_RS18555	COG1846	Transcriptional regulator
CH48_RS18560	COG3133	Outer membrane lipoprotein
CH48_RS18565	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
CH48_RS18570	COG3895	Periplasmic Protein
CH48_RS18575	COG0259	pyridoxamine-phosphate oxidase activity
CH48_RS18580	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CH48_RS18590	COG0625	glutathione transferase activity
CH48_RS18610	COG3104	oligopeptide transport
CH48_RS18630	COG4172	Belongs to the ABC transporter superfamily
CH48_RS18640	COG4171	peptide transport system, permease
CH48_RS18645	COG4168	peptide transport system, permease
CH48_RS18650	COG4166	transmembrane transport
CH48_RS18665	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
CH48_RS18670	COG1842	Phage shock protein A
CH48_RS18680	COG1983	PspC domain protein
CH48_RS18690	COG3106	COG3106 Predicted ATPase
CH48_RS18695	COG3768	UPF0283 membrane protein
CH48_RS18700	COG5654	RES domain protein
CH48_RS18705	COG5642	Protein of unknown function (DUF2384)
CH48_RS18715	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CH48_RS18720	COG4948	Mandelate Racemase Muconate Lactonizing
CH48_RS18725	COG2866	Carboxypeptidase
CH48_RS18730	COG4166	transmembrane transport
CH48_RS18735	COG0598	Magnesium transport protein CorA
CH48_RS18740	COG0037	tRNA processing
CH48_RS18745	COG0823	Involved in the tonB-independent uptake of proteins
CH48_RS18750	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CH48_RS18750	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CH48_RS18750	COG1013	pyruvate-flavodoxin oxidoreductase activity
CH48_RS18750	COG0674	pyruvate-flavodoxin oxidoreductase activity
CH48_RS18760	COG1285	pathogenesis
CH48_RS18765	COG3042	response to heat
CH48_RS18770	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CH48_RS18775	COG2911	Protein conserved in bacteria
CH48_RS18785	COG3784	Protein of unknown function (DUF1318)
CH48_RS18790	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CH48_RS18795	COG1643	Atp-dependent helicase
CH48_RS18810	COG3591	Belongs to the peptidase S1B family
CH48_RS18820	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
CH48_RS18825	COG2205	protein histidine kinase activity
CH48_RS18830	COG0745	RESPONSE REGULATOR receiver
CH48_RS18840	COG0531	amino acid
CH48_RS18855	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
CH48_RS18860	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
CH48_RS18865	COG0589	response to stress
CH48_RS18870	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CH48_RS18875	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CH48_RS18890	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
CH48_RS18895	COG1028	Short-chain dehydrogenase reductase Sdr
CH48_RS18905	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CH48_RS18910	COG0738	Major facilitator superfamily
CH48_RS18925	COG1011	Hydrolase
CH48_RS18930	COG0440	acetolactate synthase activity
CH48_RS18935	COG0028	Belongs to the TPP enzyme family
CH48_RS18945	COG3023	N-Acetylmuramoyl-L-alanine amidase
CH48_RS18975	COG2271	Major facilitator Superfamily
CH48_RS18980	COG0483	inositol monophosphate 1-phosphatase activity
CH48_RS18990	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CH48_RS19005	COG3177	Filamentation induced by cAMP protein fic
CH48_RS19035	COG4215	(ABC) transporter
CH48_RS19045	COG1522	sequence-specific DNA binding
CH48_RS19075	COG0625	glutathione transferase activity
CH48_RS19245	COG4221	oxidoreductase activity
CH48_RS19250	COG1742	UPF0060 membrane protein
CH48_RS19280	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CH48_RS19285	COG1940	carbohydrate kinase activity
CH48_RS19290	COG0583	DNA-binding transcription factor activity
CH48_RS19295	COG2814	Major facilitator Superfamily
CH48_RS19320	COG0114	fumarate hydratase activity
CH48_RS19330	COG5339	Protein conserved in bacteria
CH48_RS19340	COG1609	Transcriptional regulator
CH48_RS19345	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CH48_RS19345	COG1263	PTS System
CH48_RS19350	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CH48_RS19355	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CH48_RS19360	COG0385	Bile acid
CH48_RS19365	COG0673	inositol 2-dehydrogenase activity
CH48_RS19375	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH48_RS19380	COG1129	ABC transporter
CH48_RS19385	COG1879	ABC-type sugar transport system periplasmic component
CH48_RS19395	COG2160	L-arabinose isomerase activity
CH48_RS19400	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CH48_RS19405	COG2274	protein secretion by the type I secretion system
CH48_RS19420	COG2759	Belongs to the formate--tetrahydrofolate ligase family
CH48_RS19430	COG4657	Part of a membrane complex involved in electron transport
CH48_RS19440	COG4656	Part of a membrane complex involved in electron transport
CH48_RS19450	COG2207	Transcriptional regulator
CH48_RS19450	COG3708	Transcriptional regulator
CH48_RS19455	COG4658	electron transport chain
CH48_RS19460	COG4659	FMN binding
CH48_RS19470	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CH48_RS19490	COG0243	molybdopterin cofactor binding
CH48_RS19495	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
CH48_RS19500	COG1966	Carbon starvation protein
CH48_RS19505	COG2879	small protein
CH48_RS19510	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CH48_RS19515	COG1349	DNA-binding transcription factor activity
CH48_RS19540	COG0023	Translation Initiation Factor
CH48_RS19545	COG0284	orotidine-5'-phosphate decarboxylase activity
CH48_RS19555	COG3135	benzoate transporter
CH48_RS19560	COG1396	sequence-specific DNA binding
CH48_RS19570	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
CH48_RS19575	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
CH48_RS19580	COG0671	phosphoesterase, PA-phosphatase related
CH48_RS19605	COG0583	DNA-binding transcription factor activity
CH48_RS19620	COG0616	signal peptide processing
CH48_RS19625	COG1028	Short-chain dehydrogenase reductase Sdr
CH48_RS19630	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
CH48_RS19640	COG1187	pseudouridine synthase activity
CH48_RS19645	COG0009	L-threonylcarbamoyladenylate synthase
CH48_RS19650	COG0613	PHP domain protein
CH48_RS19660	COG0512	Glutamine amidotransferase of anthranilate synthase
CH48_RS19670	COG0134	indole-3-glycerol-phosphate synthase activity
CH48_RS19670	COG0135	phosphoribosylanthranilate isomerase activity
CH48_RS19675	COG0133	tryptophan synthase activity
CH48_RS19680	COG0159	tryptophan synthase activity
CH48_RS19690	COG3047	cAMP biosynthetic process
CH48_RS19695	COG0727	PFAM Uncharacterised protein family (UPF0153)
CH48_RS19710	COG2917	probably involved in intracellular septation
CH48_RS19715	COG1607	acyl-coa hydrolase
CH48_RS19720	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
CH48_RS19725	COG2350	Protein conserved in bacteria
CH48_RS19740	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CH48_RS19745	COG3099	Belongs to the UPF0263 family
CH48_RS19755	COG0444	Belongs to the ABC transporter superfamily
CH48_RS19760	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CH48_RS19780	COG2095	MarC family integral membrane protein
CH48_RS19785	COG1012	belongs to the aldehyde dehydrogenase family
CH48_RS19785	COG1454	alcohol dehydrogenase
CH48_RS19800	COG2916	Histone family protein nucleoid-structuring protein H-NS
CH48_RS19810	COG0745	RESPONSE REGULATOR receiver
CH48_RS19815	COG1752	Esterase of the alpha-beta hydrolase superfamily
CH48_RS19825	COG3012	SEC-C Motif Domain Protein
CH48_RS19830	COG0788	formyltetrahydrofolate deformylase activity
CH48_RS19845	COG0583	DNA-binding transcription factor activity
CH48_RS19850	COG0708	Exodeoxyribonuclease III
CH48_RS19855	COG0494	nUDIX hydrolase
CH48_RS19865	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CH48_RS19875	COG0778	Nitroreductase
CH48_RS19880	COG0616	signal peptide processing
CH48_RS19885	COG0252	asparaginase activity
CH48_RS19890	COG1335	isochorismatase
CH48_RS19900	COG3139	Protein of unknown function (DUF1315)
CH48_RS19905	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CH48_RS19920	COG3713	MltA-interacting MipA family protein
CH48_RS19925	COG2766	serine protein kinase
CH48_RS19930	COG2718	Belongs to the UPF0229 family
CH48_RS19945	COG0583	DNA-binding transcription factor activity
CH48_RS19955	COG2202	Pas domain
CH48_RS19955	COG2199	diguanylate cyclase activity
CH48_RS19955	COG2200	EAL domain
CH48_RS19960	COG2814	Major facilitator Superfamily
CH48_RS19965	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CH48_RS19970	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CH48_RS19975	COG2719	SpoVR family
CH48_RS19980	COG2186	Transcriptional regulator
CH48_RS19985	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CH48_RS19990	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
CH48_RS20010	COG3142	Participates in the control of copper homeostasis
CH48_RS20015	COG3102	Protein conserved in bacteria
CH48_RS20020	COG0018	arginyl-trna synthetase
CH48_RS20030	COG1702	phosphate starvation-inducible protein PhoH
CH48_RS20045	COG3658	cytochrome
CH48_RS20050	COG1215	transferase activity, transferring glycosyl groups
CH48_RS20055	COG0726	polysaccharide deacetylase
CH48_RS20055	COG1649	PFAM Uncharacterised BCR, COG1649
CH48_RS20065	COG0006	proline dipeptidase activity
CH48_RS20070	COG4114	ferric iron reductase
CH48_RS20075	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CH48_RS20100	COG1136	(ABC) transporter
CH48_RS20100	COG0577	efflux transmembrane transporter activity
CH48_RS20110	COG0577	efflux transmembrane transporter activity
CH48_RS20110	COG1136	(ABC) transporter
CH48_RS20125	COG0672	)-iron permease
CH48_RS20140	COG2066	Belongs to the glutaminase family
CH48_RS20145	COG3622	Belongs to the hyi family
CH48_RS20150	COG0235	Class ii aldolase
CH48_RS20155	COG3395	kinase activity
CH48_RS20160	COG1349	DNA-binding transcription factor activity
CH48_RS20165	COG3290	protein histidine kinase activity
CH48_RS20170	COG4565	transcriptional regulatory protein
CH48_RS20175	COG3493	citrate carrier protein
CH48_RS20195	COG2223	nitrite transmembrane transporter activity
CH48_RS20200	COG0561	phosphatase activity
CH48_RS20210	COG3328	transposase activity
CH48_RS20215	COG0500	methyltransferase
CH48_RS20225	COG3328	transposase activity
CH48_RS20270	COG4974	Belongs to the 'phage' integrase family
CH48_RS20280	COG1276	copper resistance
CH48_RS20285	COG2372	response to copper ion
CH48_RS20290	COG1528	Iron-storage protein
CH48_RS20305	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CH48_RS20310	COG1770	oligopeptidase
CH48_RS20320	COG3097	Belongs to the UPF0267 family
CH48_RS20325	COG3141	response to X-ray
CH48_RS20330	COG0513	Belongs to the DEAD box helicase family
CH48_RS20335	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
CH48_RS20340	COG3140	Belongs to the UPF0181 family
CH48_RS20350	COG0494	nUDIX hydrolase
CH48_RS20355	COG1760	l-serine dehydratase
CH48_RS20365	COG1253	flavin adenine dinucleotide binding
CH48_RS20370	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH48_RS20370	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CH48_RS20375	COG3715	PTS system
CH48_RS20380	COG3716	PTS system mannose fructose sorbose family IID component
CH48_RS20385	COG4811	Protein of unknown function (DUF986)
CH48_RS20390	COG1971	Probably functions as a manganese efflux pump
CH48_RS20400	COG5002	protein histidine kinase activity
CH48_RS20400	COG5001	Diguanylate cyclase
CH48_RS20400	COG3447	MASE1 domain protein
CH48_RS20410	COG2226	methyltransferase
CH48_RS20415	COG0768	penicillin binding
CH48_RS20420	COG1496	oxidoreductase activity
CH48_RS20440	COG1113	amino acid transport
CH48_RS20475	COG2207	Transcriptional regulator
CH48_RS20495	COG1132	(ABC) transporter
CH48_RS20515	COG5001	Diguanylate cyclase
CH48_RS20515	COG4251	negative regulation of phosphorylation
CH48_RS20515	COG2203	Gaf domain
CH48_RS20515	COG3706	GGDEF domain
CH48_RS20530	COG3755	Protein conserved in bacteria
CH48_RS20555	COG1733	regulation of RNA biosynthetic process
CH48_RS20560	COG0702	epimerase
CH48_RS20585	COG0840	transmembrane signaling receptor activity
CH48_RS20620	COG0538	isocitrate dehydrogenase activity
CH48_RS20655	COG0538	isocitrate dehydrogenase activity
CH48_RS20660	COG1187	pseudouridine synthase activity
CH48_RS20670	COG0482	sulfurtransferase activity
CH48_RS20675	COG2915	High frequency lysogenization protein hflD homolog
CH48_RS20680	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CH48_RS20690	COG0745	RESPONSE REGULATOR receiver
CH48_RS20700	COG2850	peptidyl-arginine hydroxylation
CH48_RS20715	COG1940	carbohydrate kinase activity
CH48_RS20720	COG4591	ABC-type transport system involved in lipoprotein release permease component
CH48_RS20730	COG4591	ABC-type transport system involved in lipoprotein release permease component
CH48_RS20735	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CH48_RS20740	COG3134	Outer membrane lipoprotein
CH48_RS20745	COG1252	NADH dehydrogenase
CH48_RS20750	COG3150	esterase
CH48_RS20755	COG1472	Belongs to the glycosyl hydrolase 3 family
CH48_RS20765	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
CH48_RS20770	COG5633	Lipoprotein
CH48_RS20775	COG0537	adenosine 5'-monophosphoramidase activity
CH48_RS20780	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CH48_RS20790	COG0641	radical SAM
CH48_RS20810	COG1263	PTS System
CH48_RS20810	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CH48_RS20815	COG0084	hydrolase, TatD family'
CH48_RS20820	COG0470	DNA polymerase III
CH48_RS20825	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CH48_RS20905	COG4221	oxidoreductase activity