locus-tag	class	description
I6I39_RS00010	COG1338	Plays a role in the flagellum-specific transport system
I6I39_RS00030	COG1256	bacterial-type flagellum assembly
I6I39_RS00065	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
I6I39_RS00070	COG1558	bacterial-type flagellum-dependent cell motility
I6I39_RS00075	COG1815	bacterial-type flagellum-dependent cell motility
I6I39_RS00085	COG2747	anti-sigma28 factor FlgM
I6I39_RS00090	COG3418	PFAM FlgN family protein
I6I39_RS00110	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I6I39_RS00115	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I6I39_RS00120	COG1404	Belongs to the peptidase S8 family
I6I39_RS00120	COG4935	Belongs to the peptidase S8 family
I6I39_RS00125	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
I6I39_RS00130	COG0745	RESPONSE REGULATOR receiver
I6I39_RS00140	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I6I39_RS00145	COG0840	transmembrane signaling receptor activity
I6I39_RS00150	COG0840	transmembrane signaling receptor activity
I6I39_RS00155	COG0835	chemotaxis
I6I39_RS00160	COG2198	Histidine kinase
I6I39_RS00160	COG0643	Histidine kinase
I6I39_RS00165	COG1360	Flagellar Motor Protein
I6I39_RS00185	COG0589	response to stress
I6I39_RS00190	COG2130	NADP-dependent
I6I39_RS00200	COG1285	pathogenesis
I6I39_RS00215	COG0840	transmembrane signaling receptor activity
I6I39_RS00230	COG1609	Transcriptional regulator
I6I39_RS00235	COG3250	beta-galactosidase activity
I6I39_RS00240	COG3328	transposase activity
I6I39_RS00245	COG3321	synthase
I6I39_RS00245	COG0604	alcohol dehydrogenase
I6I39_RS00245	COG1028	Short-chain dehydrogenase reductase Sdr
I6I39_RS00280	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I6I39_RS00290	COG3263	regulation of cellular component size
I6I39_RS00300	COG3916	Acyl-homoserine-lactone synthase
I6I39_RS00305	COG2771	luxR family
I6I39_RS00310	COG4235	cytochrome complex assembly
I6I39_RS00315	COG3088	subunit of a heme lyase
I6I39_RS00320	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6I39_RS00325	COG1138	Cytochrome C-type biogenesis protein
I6I39_RS00330	COG3301	Polysulphide reductase, NrfD
I6I39_RS00335	COG0437	4 iron, 4 sulfur cluster binding
I6I39_RS00340	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
I6I39_RS00355	COG2920	part of a sulfur-relay system
I6I39_RS00360	COG1254	Belongs to the acylphosphatase family
I6I39_RS00375	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I6I39_RS00380	COG3785	DNA binding
I6I39_RS00385	COG1832	CoA-binding protein
I6I39_RS00395	COG1803	Methylglyoxal synthase
I6I39_RS00400	COG0210	DNA helicase
I6I39_RS00405	COG3304	Inner membrane component domain
I6I39_RS00410	COG1289	transmembrane transporter activity
I6I39_RS00415	COG3070	regulator of competence-specific genes
I6I39_RS00420	COG5404	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
I6I39_RS00430	COG3120	sequence-specific DNA binding
I6I39_RS00435	COG1067	ATP-dependent peptidase activity
I6I39_RS00440	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6I39_RS00450	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6I39_RS00455	COG3130	regulation of translation
I6I39_RS00460	COG3009	Protein conserved in bacteria
I6I39_RS00465	COG3008	intermembrane lipid transfer
I6I39_RS00465	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6I39_RS00470	COG2995	paraquat-inducible protein a
I6I39_RS00475	COG0488	(ABC) transporter
I6I39_RS00480	COG0116	Belongs to the methyltransferase superfamily
I6I39_RS00480	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I6I39_RS00485	COG0633	Ferredoxin
I6I39_RS00485	COG3217	Mosc domain protein beta barrel domain protein
I6I39_RS00495	COG0167	dihydroorotate dehydrogenase activity
I6I39_RS00500	COG0308	aminopeptidase N
I6I39_RS00505	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I6I39_RS00510	COG0017	Asparaginyl-tRNA synthetase
I6I39_RS00520	COG1448	Aminotransferase
I6I39_RS00525	COG2200	EAL domain
I6I39_RS00530	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6I39_RS00535	COG3108	Peptidase M15
I6I39_RS00540	COG2989	Protein conserved in bacteria
I6I39_RS00545	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
I6I39_RS00555	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
I6I39_RS00560	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6I39_RS00565	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I6I39_RS00570	COG3173	Aminoglycoside phosphotransferase
I6I39_RS00575	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
I6I39_RS00580	COG2835	tetraacyldisaccharide 4'-kinase activity
I6I39_RS00585	COG1278	Cold shock
I6I39_RS00595	COG5383	Protein conserved in bacteria
I6I39_RS00600	COG1663	tetraacyldisaccharide 4'-kinase activity
I6I39_RS00610	COG0658	competence protein
I6I39_RS00610	COG2333	competence protein COMEC
I6I39_RS00615	COG0776	regulation of translation
I6I39_RS00620	COG0539	negative regulation of cytoplasmic translation
I6I39_RS00625	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I6I39_RS00630	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I6I39_RS00635	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
I6I39_RS00640	COG2323	membrane
I6I39_RS00645	COG0252	asparaginase activity
I6I39_RS00650	COG1944	ATP diphosphatase activity
I6I39_RS00660	COG2116	formate transmembrane transporter activity
I6I39_RS00665	COG1882	Formate acetyltransferase
I6I39_RS00670	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6I39_RS00675	COG2814	Major facilitator Superfamily
I6I39_RS00680	COG3328	transposase activity
I6I39_RS00690	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I6I39_RS00695	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6I39_RS00700	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
I6I39_RS00705	COG3107	peptidoglycan biosynthetic process
I6I39_RS00705	COG1674	ftsk spoiiie
I6I39_RS00710	COG1522	sequence-specific DNA binding
I6I39_RS00715	COG0492	ferredoxin-NADP+ reductase activity
I6I39_RS00725	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I6I39_RS00730	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
I6I39_RS00735	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I6I39_RS00740	COG0542	response to heat
I6I39_RS00745	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I6I39_RS00750	COG1278	Cold shock
I6I39_RS00760	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I39_RS00765	COG2990	Protein conserved in bacteria
I6I39_RS00770	COG3593	DNA synthesis involved in DNA repair
I6I39_RS00775	COG2431	L-lysine efflux transmembrane transporter activity
I6I39_RS00780	COG1151	hydroxylamine reductase activity
I6I39_RS00785	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6I39_RS00790	COG0028	Belongs to the TPP enzyme family
I6I39_RS00800	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
I6I39_RS00805	COG0702	epimerase
I6I39_RS00810	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6I39_RS00820	COG1126	abc transporter atp-binding protein
I6I39_RS00825	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I39_RS00830	COG4215	(ABC) transporter
I6I39_RS00835	COG4160	amino acid transport
I6I39_RS00840	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I39_RS00845	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6I39_RS00855	COG1177	transmembrane transport
I6I39_RS00860	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6I39_RS00865	COG3842	ATPase activity
I6I39_RS00870	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I6I39_RS00890	COG2985	domain, Protein
I6I39_RS00890	COG0569	domain protein
I6I39_RS00900	COG0671	phosphoesterase, PA-phosphatase related
I6I39_RS00905	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
I6I39_RS00910	COG1349	DNA-binding transcription factor activity
I6I39_RS00915	COG0814	amino acid
I6I39_RS00920	COG1760	l-serine dehydratase
I6I39_RS00930	COG1686	Belongs to the peptidase S11 family
I6I39_RS00940	COG0626	cystathionine gamma-synthase activity
I6I39_RS00945	COG2011	ABC-type metal ion transport system permease component
I6I39_RS00970	COG0625	glutathione transferase activity
I6I39_RS00975	COG4771	TonB-dependent receptor
I6I39_RS00985	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I39_RS00990	COG0833	amino acid
I6I39_RS00995	COG0583	DNA-binding transcription factor activity
I6I39_RS01005	COG2855	membrane
I6I39_RS01010	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
I6I39_RS01035	COG3710	Transcriptional regulator
I6I39_RS01040	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6I39_RS01040	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6I39_RS01040	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
I6I39_RS01045	COG1105	Belongs to the carbohydrate kinase PfkB family
I6I39_RS01060	COG3005	denitrification pathway
I6I39_RS01065	COG0243	molybdopterin cofactor binding
I6I39_RS01080	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6I39_RS01085	COG1312	Catalyzes the dehydration of D-mannonate
I6I39_RS01095	COG0246	Mannitol dehydrogenase
I6I39_RS01100	COG2186	Transcriptional regulator
I6I39_RS01110	COG0523	cobalamin synthesis protein
I6I39_RS01115	COG0671	phosphoesterase, PA-phosphatase related
I6I39_RS01120	COG0791	NLP P60 protein
I6I39_RS01125	COG2200	EAL domain
I6I39_RS01130	COG4166	transmembrane transport
I6I39_RS01135	COG4174	ABC transporter (Permease)
I6I39_RS01140	COG4239	(ABC) transporter, permease
I6I39_RS01145	COG4172	Belongs to the ABC transporter superfamily
I6I39_RS01155	COG2814	Major facilitator Superfamily
I6I39_RS01160	COG1187	pseudouridine synthase activity
I6I39_RS01165	COG1061	Type III restriction enzyme res subunit
I6I39_RS01170	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I6I39_RS01175	COG3081	Nucleoid-associated protein
I6I39_RS01180	COG3082	Protein of unknown function (DUF1414)
I6I39_RS01205	COG3328	transposase activity
I6I39_RS01215	COG2723	6-phospho-beta-galactosidase activity
I6I39_RS01220	COG2190	(PTS) system
I6I39_RS01220	COG1263	PTS System
I6I39_RS01220	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I39_RS01225	COG1737	Transcriptional regulator
I6I39_RS01275	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6I39_RS01290	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6I39_RS01300	COG2223	nitrite transmembrane transporter activity
I6I39_RS01305	COG0642	Histidine kinase
I6I39_RS01305	COG2198	Histidine kinase
I6I39_RS01310	COG2197	response regulator
I6I39_RS01315	COG0784	Response regulator, receiver
I6I39_RS01315	COG2205	protein histidine kinase activity
I6I39_RS01325	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6I39_RS01330	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6I39_RS01340	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6I39_RS01345	COG4574	serine-type endopeptidase inhibitor activity
I6I39_RS01365	COG0814	amino acid
I6I39_RS01385	COG1441	menaquinone biosynthetic process
I6I39_RS01390	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
I6I39_RS01395	COG0596	Alpha beta hydrolase
I6I39_RS01400	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
I6I39_RS01405	COG1169	isochorismate synthase
I6I39_RS01410	COG4575	ribosome binding
I6I39_RS01415	COG0129	dihydroxy-acid dehydratase activity
I6I39_RS01420	COG4702	Belongs to the UPF0303 family
I6I39_RS01430	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6I39_RS01435	COG1609	Transcriptional regulator
I6I39_RS01440	COG1028	Short-chain dehydrogenase reductase Sdr
I6I39_RS01445	COG3265	gluconokinase activity
I6I39_RS01465	COG1007	ATP synthesis coupled electron transport
I6I39_RS01470	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6I39_RS01475	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6I39_RS01480	COG0713	ATP synthesis coupled electron transport
I6I39_RS01485	COG0839	Belongs to the complex I subunit 6 family
I6I39_RS01490	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6I39_RS01495	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
I6I39_RS01500	COG1034	ATP synthesis coupled electron transport
I6I39_RS01515	COG0649	NAD binding
I6I39_RS01515	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6I39_RS01520	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6I39_RS01525	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6I39_RS01530	COG0583	DNA-binding transcription factor activity
I6I39_RS01535	COG0436	Aminotransferase
I6I39_RS01540	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
I6I39_RS01545	COG0471	metal ion transport
I6I39_RS01545	COG0490	domain, Protein
I6I39_RS01555	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6I39_RS01560	COG3013	Belongs to the UPF0304 family
I6I39_RS01565	COG3092	negative regulation of chromosome organization
I6I39_RS01575	COG0857	belongs to the CobB CobQ family
I6I39_RS01575	COG0280	phosphate acetyltransferase
I6I39_RS01580	COG1609	Transcriptional regulator
I6I39_RS01585	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I39_RS01595	COG3037	sugar-specific permease SgaT UlaA
I6I39_RS01610	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
I6I39_RS01615	COG0622	Phosphoesterase
I6I39_RS01625	COG1090	epimerase
I6I39_RS01640	COG4598	ABC transporter
I6I39_RS01645	COG4160	amino acid transport
I6I39_RS01650	COG4215	(ABC) transporter
I6I39_RS01655	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I39_RS01660	COG0163	prenyltransferase activity
I6I39_RS01665	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I6I39_RS01670	COG1286	toxin biosynthetic process
I6I39_RS01675	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
I6I39_RS01680	COG0285	dihydrofolate synthase activity
I6I39_RS01685	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
I6I39_RS01690	COG0586	Pfam SNARE associated Golgi protein
I6I39_RS01700	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6I39_RS01705	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6I39_RS01715	COG0697	spore germination
I6I39_RS01720	COG0697	spore germination
I6I39_RS01730	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I39_RS01735	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6I39_RS01760	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I6I39_RS01770	COG1609	Transcriptional regulator
I6I39_RS01780	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6I39_RS01785	COG2723	6-phospho-beta-galactosidase activity
I6I39_RS01790	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6I39_RS01800	COG1794	racemase activity, acting on amino acids and derivatives
I6I39_RS01810	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6I39_RS01815	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6I39_RS01815	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
I6I39_RS01825	COG3101	peptidyl-lysine hydroxylation
I6I39_RS01830	COG0730	response to heat
I6I39_RS01835	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
I6I39_RS01840	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
I6I39_RS01845	COG2890	protein-(glutamine-N5) methyltransferase activity
I6I39_RS01850	COG2840	Smr protein MutS2
I6I39_RS01855	COG2062	phosphohistidine phosphatase, SixA
I6I39_RS01860	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6I39_RS01860	COG1024	Enoyl-CoA hydratase
I6I39_RS01865	COG0183	Belongs to the thiolase family
I6I39_RS01870	COG3691	Protein conserved in bacteria
I6I39_RS01885	COG4235	cytochrome complex assembly
I6I39_RS01885	COG3088	subunit of a heme lyase
I6I39_RS01895	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6I39_RS01900	COG1138	Cytochrome C-type biogenesis protein
I6I39_RS01905	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
I6I39_RS01910	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6I39_RS01915	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6I39_RS01920	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6I39_RS01930	COG2116	formate transmembrane transporter activity
I6I39_RS01950	COG2824	Alkylphosphonate utilization operon protein PhnA
I6I39_RS01955	COG1695	Transcriptional regulator
I6I39_RS01965	COG2723	6-phospho-beta-galactosidase activity
I6I39_RS01970	COG1263	PTS System
I6I39_RS01970	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I39_RS01975	COG1609	Transcriptional regulator
I6I39_RS01980	COG2353	YceI-like domain
I6I39_RS01985	COG3038	cytochrome b561
I6I39_RS01990	COG0657	acetylesterase activity
I6I39_RS01990	COG2755	lipolytic protein G-D-S-L family
I6I39_RS02010	COG1127	ABC transporter
I6I39_RS02015	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6I39_RS02035	COG0531	amino acid
I6I39_RS02040	COG2951	lytic endotransglycosylase activity
I6I39_RS02060	COG1280	lysine exporter protein (LysE YggA)
I6I39_RS02070	COG1598	PFAM Uncharacterised protein family UPF0150
I6I39_RS02080	COG3038	cytochrome b561
I6I39_RS02085	COG0436	Aminotransferase
I6I39_RS02100	COG3275	phosphorelay sensor kinase activity
I6I39_RS02105	COG3279	Response regulator of the LytR AlgR family
I6I39_RS02110	COG2223	nitrite transmembrane transporter activity
I6I39_RS02115	COG0837	glucose binding
I6I39_RS02130	COG3961	Belongs to the TPP enzyme family
I6I39_RS02135	COG0667	Aldo Keto reductase
I6I39_RS02145	COG1914	H( )-stimulated, divalent metal cation uptake system
I6I39_RS02150	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6I39_RS02175	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6I39_RS02200	COG3530	Putative quorum-sensing-regulated virulence factor
I6I39_RS02205	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6I39_RS02225	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I39_RS02230	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6I39_RS02240	COG2205	protein histidine kinase activity
I6I39_RS02245	COG0745	RESPONSE REGULATOR receiver
I6I39_RS02250	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I39_RS02270	COG4208	sulfate ABC transporter
I6I39_RS02275	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
I6I39_RS02280	COG4150	thiosulfate binding
I6I39_RS02290	COG1737	Transcriptional regulator
I6I39_RS02295	COG2731	YhcH YjgK YiaL family protein
I6I39_RS02310	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6I39_RS02320	COG2837	iron assimilation
I6I39_RS02330	COG3111	PFAM Bacterial OB fold (BOF) protein
I6I39_RS02335	COG0456	acetyltransferase
I6I39_RS02340	COG0408	coproporphyrinogen oxidase activity
I6I39_RS02345	COG1671	Belongs to the UPF0178 family
I6I39_RS02365	COG0280	phosphate acetyltransferase
I6I39_RS02365	COG0281	malic enzyme
I6I39_RS02370	COG0494	nUDIX hydrolase
I6I39_RS02375	COG3005	denitrification pathway
I6I39_RS02380	COG3043	anaerobic respiration
I6I39_RS02385	COG0243	molybdopterin cofactor binding
I6I39_RS02390	COG3062	negative regulation of establishment of protein localization
I6I39_RS02400	COG2197	response regulator
I6I39_RS02410	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6I39_RS02425	COG1393	Belongs to the ArsC family
I6I39_RS02430	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6I39_RS02435	COG1876	peptidase activity
I6I39_RS02480	COG0400	carboxylic ester hydrolase activity
I6I39_RS02490	COG1444	tRNA N-acetyltransferase activity
I6I39_RS02495	COG2707	UPF0756 membrane protein
I6I39_RS02500	COG2321	neutral zinc metallopeptidase
I6I39_RS02505	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I6I39_RS02510	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
I6I39_RS02515	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6I39_RS02520	COG2716	regulation of RNA biosynthetic process
I6I39_RS02525	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6I39_RS02530	COG0628	permease
I6I39_RS02535	COG4783	chaperone-mediated protein folding
I6I39_RS02540	COG1393	Belongs to the ArsC family
I6I39_RS02545	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6I39_RS02550	COG2233	PERMEase
I6I39_RS02555	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I6I39_RS02560	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I6I39_RS02565	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6I39_RS02570	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6I39_RS02575	COG5001	Diguanylate cyclase
I6I39_RS02575	COG5002	protein histidine kinase activity
I6I39_RS02575	COG3447	MASE1 domain protein
I6I39_RS02580	COG2239	Acts as a magnesium transporter
I6I39_RS02595	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
I6I39_RS02600	COG0573	inorganic phosphate transmembrane transporter activity
I6I39_RS02605	COG0581	inorganic phosphate transmembrane transporter activity
I6I39_RS02615	COG5002	protein histidine kinase activity
I6I39_RS02615	COG3447	MASE1 domain protein
I6I39_RS02615	COG5001	Diguanylate cyclase
I6I39_RS02620	COG0443	Heat shock 70 kDa protein
I6I39_RS02630	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I39_RS02640	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6I39_RS02645	COG0477	Major facilitator Superfamily
I6I39_RS02650	COG2205	protein histidine kinase activity
I6I39_RS02655	COG0745	RESPONSE REGULATOR receiver
I6I39_RS02660	COG3422	double-strand break repair
I6I39_RS02665	COG0826	peptidase U32
I6I39_RS02670	COG1597	lipid kinase activity
I6I39_RS02675	COG3730	PTS system glucitol sorbitol-specific
I6I39_RS02690	COG1028	Short-chain dehydrogenase reductase Sdr
I6I39_RS02695	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I39_RS02700	COG1349	DNA-binding transcription factor activity
I6I39_RS02720	COG0351	phosphomethylpyrimidine kinase
I6I39_RS02755	COG0519	Catalyzes the synthesis of GMP from XMP
I6I39_RS02755	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6I39_RS02760	COG0517	IMP dehydrogenase activity
I6I39_RS02760	COG0516	GMP reductase activity
I6I39_RS02765	COG1570	exodeoxyribonuclease VII activity
I6I39_RS02770	COG1645	bacterial-type flagellum-dependent swarming motility
I6I39_RS02780	COG1160	GTP binding
I6I39_RS02785	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6I39_RS02790	COG2976	Protein conserved in bacteria
I6I39_RS02795	COG0124	histidyl-tRNA synthetase
I6I39_RS02800	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
I6I39_RS02805	COG1426	Protein conserved in bacteria
I6I39_RS02815	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I6I39_RS02830	COG4953	penicillin-binding protein 1C
I6I39_RS02835	COG2373	Large extracellular alpha-helical protein
I6I39_RS02845	COG3468	outer membrane autotransporter barrel domain protein
I6I39_RS02860	COG2975	iron-sulfur cluster assembly
I6I39_RS02865	COG0633	Ferredoxin
I6I39_RS02870	COG0443	Heat shock 70 kDa protein
I6I39_RS02875	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
I6I39_RS02880	COG0316	Belongs to the HesB IscA family
I6I39_RS02885	COG0822	iron-sulfur transferase activity
I6I39_RS02895	COG1959	2 iron, 2 sulfur cluster binding
I6I39_RS02900	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
I6I39_RS02910	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
I6I39_RS02915	COG3683	transport system, periplasmic component
I6I39_RS02920	COG3711	transcriptional antiterminator
I6I39_RS02925	COG2814	Major facilitator Superfamily
I6I39_RS02930	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I6I39_RS02935	COG1017	nitric oxide dioxygenase activity
I6I39_RS02935	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6I39_RS02940	COG2188	Transcriptional regulator
I6I39_RS02950	COG3457	Alanine racemase
I6I39_RS02955	COG1735	metal-dependent hydrolase with the TIM-barrel fold
I6I39_RS02970	COG0347	Belongs to the P(II) protein family
I6I39_RS02975	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I6I39_RS02975	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6I39_RS02980	COG2204	response regulator
I6I39_RS02985	COG3170	Tfp pilus assembly protein FimV
I6I39_RS02990	COG2205	protein histidine kinase activity
I6I39_RS03005	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
I6I39_RS03020	COG0560	Phosphoserine phosphatase
I6I39_RS03030	COG1737	Transcriptional regulator
I6I39_RS03035	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6I39_RS03040	COG2610	gluconate transmembrane transporter activity
I6I39_RS03045	COG0736	holo-[acyl-carrier-protein] synthase activity
I6I39_RS03050	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I6I39_RS03055	COG1381	Involved in DNA repair and RecF pathway recombination
I6I39_RS03060	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I6I39_RS03065	COG0571	ribonuclease III activity
I6I39_RS03075	COG0481	GTPase activity
I6I39_RS03085	COG3086	response to oxidative stress
I6I39_RS03095	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
I6I39_RS03105	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I6I39_RS03110	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I6I39_RS03115	COG0513	Belongs to the DEAD box helicase family
I6I39_RS03140	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
I6I39_RS03145	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I6I39_RS03150	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I6I39_RS03155	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I6I39_RS03160	COG0497	DNA recombination
I6I39_RS03165	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6I39_RS03175	COG2867	negative regulation of translational initiation
I6I39_RS03180	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I6I39_RS03190	COG0582	viral genome integration into host DNA
I6I39_RS03195	COG3328	transposase activity
I6I39_RS03200	COG0659	secondary active sulfate transmembrane transporter activity
I6I39_RS03205	COG3394	polysaccharide catabolic process
I6I39_RS03210	COG2169	Transcriptional regulator
I6I39_RS03210	COG1917	Cupin 2, conserved barrel domain protein
I6I39_RS03215	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6I39_RS03220	COG2723	6-phospho-beta-galactosidase activity
I6I39_RS03225	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6I39_RS03230	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6I39_RS03235	COG2133	pyrroloquinoline quinone binding
I6I39_RS03245	COG0667	Aldo Keto reductase
I6I39_RS03260	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6I39_RS03270	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
I6I39_RS03275	COG4413	Urea transporter
I6I39_RS03280	COG0829	nickel cation binding
I6I39_RS03285	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I6I39_RS03290	COG0830	nickel cation binding
I6I39_RS03295	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
I6I39_RS03300	COG0804	urea catabolic process
I6I39_RS03305	COG0832	Belongs to the urease beta subunit family
I6I39_RS03310	COG0831	urea catabolic process
I6I39_RS03315	COG1124	(ABC) transporter
I6I39_RS03325	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I39_RS03360	COG1278	Cold shock
I6I39_RS03385	COG2207	Transcriptional regulator
I6I39_RS03400	COG4575	ribosome binding
I6I39_RS03410	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6I39_RS03420	COG1780	Probably involved in ribonucleotide reductase function
I6I39_RS03430	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6I39_RS03440	COG4176	ABC-type proline glycine betaine transport system permease component
I6I39_RS03445	COG2113	Glycine betaine
I6I39_RS03460	COG0328	RNA-DNA hybrid ribonuclease activity
I6I39_RS03465	COG2226	methyltransferase
I6I39_RS03470	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6I39_RS03475	COG1388	LysM domain
I6I39_RS03475	COG0741	lytic transglycosylase activity
I6I39_RS03485	COG3021	interspecies interaction between organisms
I6I39_RS03490	COG2814	Major facilitator Superfamily
I6I39_RS03495	COG0583	DNA-binding transcription factor activity
I6I39_RS03500	COG0656	L-ascorbic acid biosynthetic process
I6I39_RS03510	COG3328	transposase activity
I6I39_RS03540	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I6I39_RS03550	COG2011	ABC-type metal ion transport system permease component
I6I39_RS03555	COG1464	Belongs to the NlpA lipoprotein family
I6I39_RS03565	COG1720	tRNA m6t6A37 methyltransferase activity
I6I39_RS03570	COG0442	prolyl-tRNA aminoacylation
I6I39_RS03575	COG3015	lipoprotein NlpE involved in copper resistance
I6I39_RS03585	COG4681	YaeQ
I6I39_RS03595	COG4568	rho-dependent transcription termination
I6I39_RS03610	COG0346	lactoylglutathione lyase activity
I6I39_RS03615	COG1982	Orn Lys Arg decarboxylase major
I6I39_RS03620	COG0825	malonyl-CoA metabolic process
I6I39_RS03630	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6I39_RS03640	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6I39_RS03645	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6I39_RS03650	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6I39_RS03655	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
I6I39_RS03665	COG0750	zinc metalloprotease
I6I39_RS03670	COG0575	Belongs to the CDS family
I6I39_RS03680	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I6I39_RS03685	COG0233	cytoplasmic translational termination
I6I39_RS03690	COG0528	UMP kinase activity
I6I39_RS03695	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I6I39_RS03700	COG0052	Belongs to the universal ribosomal protein uS2 family
I6I39_RS03710	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
I6I39_RS03715	COG2171	N-acyltransferase activity
I6I39_RS03730	COG0564	pseudouridine synthase activity
I6I39_RS03735	COG3098	single-species biofilm formation
I6I39_RS03745	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I6I39_RS03745	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I6I39_RS03750	COG1611	Belongs to the LOG family
I6I39_RS03755	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6I39_RS03760	COG3328	transposase activity
I6I39_RS03770	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
I6I39_RS03775	COG2363	Small membrane protein
I6I39_RS03780	COG0583	DNA-binding transcription factor activity
I6I39_RS03790	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6I39_RS03795	COG2166	iron-sulfur cluster assembly
I6I39_RS03800	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I6I39_RS03805	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
I6I39_RS03820	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6I39_RS03825	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I6I39_RS03825	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6I39_RS03835	COG0484	heat shock protein binding
I6I39_RS03845	COG1028	Short-chain dehydrogenase reductase Sdr
I6I39_RS03850	COG1733	regulation of RNA biosynthetic process
I6I39_RS03855	COG0288	reversible hydration of carbon dioxide
I6I39_RS03880	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6I39_RS03890	COG2165	general secretion pathway protein
I6I39_RS03915	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
I6I39_RS03955	COG2814	Major facilitator Superfamily
I6I39_RS03960	COG0583	DNA-binding transcription factor activity
I6I39_RS03970	COG1609	Transcriptional regulator
I6I39_RS03985	COG0318	PFAM AMP-dependent synthetase and ligase
I6I39_RS03985	COG0204	Acyl-transferase
I6I39_RS03990	COG0477	Major facilitator Superfamily
I6I39_RS03995	COG0667	Aldo Keto reductase
I6I39_RS04000	COG0861	Integral membrane protein TerC family
I6I39_RS04005	COG3066	DNA modification
I6I39_RS04010	COG1051	belongs to the nudix hydrolase family
I6I39_RS04020	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I6I39_RS04025	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I6I39_RS04030	COG2165	general secretion pathway protein
I6I39_RS04045	COG4967	type IV pilus modification protein PilV
I6I39_RS04050	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I6I39_RS04055	COG1025	Belongs to the peptidase M16 family
I6I39_RS04060	COG1074	ATP-dependent DNA helicase activity
I6I39_RS04065	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6I39_RS04075	COG3706	GGDEF domain
I6I39_RS04080	COG4319	ketosteroid isomerase
I6I39_RS04095	COG3328	transposase activity
I6I39_RS04100	COG2944	sequence-specific DNA binding
I6I39_RS04125	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I6I39_RS04135	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6I39_RS04140	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6I39_RS04145	COG4974	Belongs to the 'phage' integrase family
I6I39_RS04150	COG0716	FMN binding
I6I39_RS04155	COG4452	Inner membrane protein CreD
I6I39_RS04165	COG0745	RESPONSE REGULATOR receiver
I6I39_RS04180	COG0354	folic acid binding
I6I39_RS04190	COG1272	protein, Hemolysin III
I6I39_RS04200	COG1028	Short-chain dehydrogenase reductase Sdr
I6I39_RS04210	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6I39_RS04210	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6I39_RS04215	COG0509	glycine decarboxylation via glycine cleavage system
I6I39_RS04220	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I6I39_RS04225	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6I39_RS04230	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6I39_RS04235	COG0006	proline dipeptidase activity
I6I39_RS04240	COG3079	Belongs to the UPF0149 family
I6I39_RS04245	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
I6I39_RS04255	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6I39_RS04260	COG0148	phosphopyruvate hydratase activity
I6I39_RS04265	COG0504	CTP synthase activity
I6I39_RS04270	COG3956	TIGRFAM MazG family protein
I6I39_RS04275	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6I39_RS04280	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6I39_RS04285	COG3850	Histidine kinase
I6I39_RS04285	COG2205	protein histidine kinase activity
I6I39_RS04285	COG3437	response regulator, receiver
I6I39_RS04285	COG4999	Histidine kinase
I6I39_RS04290	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6I39_RS04295	COG0232	Belongs to the dGTPase family. Type 2 subfamily
I6I39_RS04300	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6I39_RS04310	COG2860	membrane
I6I39_RS04315	COG0316	Belongs to the HesB IscA family
I6I39_RS04325	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I6I39_RS04330	COG2223	nitrite transmembrane transporter activity
I6I39_RS04335	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I39_RS04340	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6I39_RS04345	COG1120	ATPase activity
I6I39_RS04350	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6I39_RS04355	COG1643	Atp-dependent helicase
I6I39_RS04360	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
I6I39_RS04365	COG1489	DNA binding
I6I39_RS04385	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I6I39_RS04390	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
I6I39_RS04395	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I6I39_RS04400	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
I6I39_RS04405	COG0726	polysaccharide deacetylase
I6I39_RS04410	COG0842	Transport permease protein
I6I39_RS04415	COG1131	(ABC) transporter
I6I39_RS04420	COG0288	reversible hydration of carbon dioxide
I6I39_RS04430	COG2132	Multicopper oxidase
I6I39_RS04440	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
I6I39_RS04445	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
I6I39_RS04460	COG3112	Uncharacterised protein family (UPF0231)
I6I39_RS04475	COG4977	sequence-specific DNA binding
I6I39_RS04485	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6I39_RS04490	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6I39_RS04495	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I6I39_RS04500	COG2186	Transcriptional regulator
I6I39_RS04505	COG1113	amino acid transport
I6I39_RS04510	COG3725	Membrane protein required for beta-lactamase induction
I6I39_RS04525	COG4969	Belongs to the N-Me-Phe pilin family
I6I39_RS04530	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6I39_RS04535	COG1459	type II secretion system
I6I39_RS04540	COG0516	GMP reductase activity
I6I39_RS04555	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
I6I39_RS04560	COG0494	nUDIX hydrolase
I6I39_RS04565	COG0653	protein targeting
I6I39_RS04585	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6I39_RS04590	COG0849	cell division
I6I39_RS04595	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I6I39_RS04605	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6I39_RS04610	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6I39_RS04615	COG0772	Belongs to the SEDS family
I6I39_RS04625	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6I39_RS04630	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6I39_RS04635	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6I39_RS04640	COG0768	penicillin binding
I6I39_RS04645	COG3116	cell division
I6I39_RS04650	COG0275	rRNA processing
I6I39_RS04655	COG2001	Belongs to the MraZ family
I6I39_RS04675	COG0028	Belongs to the TPP enzyme family
I6I39_RS04680	COG1022	Amp-dependent synthetase and ligase
I6I39_RS04695	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6I39_RS04700	COG0473	3-isopropylmalate dehydrogenase activity
I6I39_RS04705	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I6I39_RS04725	COG0814	amino acid
I6I39_RS04730	COG2814	Major facilitator Superfamily
I6I39_RS04735	COG1882	Formate acetyltransferase
I6I39_RS04740	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6I39_RS04745	COG4533	DNA binding
I6I39_RS04760	COG4143	(ABC) transporter
I6I39_RS04765	COG1178	ABC-type Fe3 transport system permease component
I6I39_RS04775	COG0586	Pfam SNARE associated Golgi protein
I6I39_RS04780	COG0417	DNA replication proofreading
I6I39_RS04785	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6I39_RS04790	COG1470	cell adhesion involved in biofilm formation
I6I39_RS04790	COG1388	LysM domain
I6I39_RS04795	COG0564	pseudouridine synthase activity
I6I39_RS04800	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
I6I39_RS04805	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
I6I39_RS04820	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I6I39_RS04825	COG2967	ApaG domain
I6I39_RS04830	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6I39_RS04835	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I6I39_RS04840	COG3610	response to peptide
I6I39_RS04845	COG2966	Psort location CytoplasmicMembrane, score
I6I39_RS04850	COG1280	lysine exporter protein (LysE YggA)
I6I39_RS04855	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I6I39_RS04865	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I6I39_RS04870	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
I6I39_RS04875	COG1047	Peptidyl-prolyl cis-trans
I6I39_RS04880	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I6I39_RS04885	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I6I39_RS04890	COG0196	riboflavin kinase activity
I6I39_RS04895	COG0268	Binds directly to 16S ribosomal RNA
I6I39_RS04900	COG0583	DNA-binding transcription factor activity
I6I39_RS04905	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I6I39_RS04910	COG0484	heat shock protein binding
I6I39_RS04915	COG0443	Heat shock 70 kDa protein
I6I39_RS04920	COG1584	GPR1 FUN34 yaaH family protein
I6I39_RS04935	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6I39_RS04940	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6I39_RS04945	COG3022	response to hydroperoxide
I6I39_RS04960	COG0083	homoserine kinase activity
I6I39_RS04975	COG0745	RESPONSE REGULATOR receiver
I6I39_RS04980	COG3045	CreA protein
I6I39_RS04985	COG2207	Transcriptional regulator
I6I39_RS04985	COG3708	Transcriptional regulator
I6I39_RS04990	COG0406	alpha-ribazole phosphatase activity
I6I39_RS04995	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
I6I39_RS05000	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
I6I39_RS05005	COG0741	lytic transglycosylase activity
I6I39_RS05010	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I6I39_RS05020	COG2199	diguanylate cyclase activity
I6I39_RS05025	COG2885	chlorophyll binding
I6I39_RS05030	COG0488	(ABC) transporter
I6I39_RS05045	COG0604	alcohol dehydrogenase
I6I39_RS05070	COG0560	Phosphoserine phosphatase
I6I39_RS05075	COG3726	membrane protein affecting hemolysin expression
I6I39_RS05080	COG0813	purine-nucleoside phosphorylase activity
I6I39_RS05085	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
I6I39_RS05090	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
I6I39_RS05100	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6I39_RS05105	COG0084	hydrolase, TatD family'
I6I39_RS05110	COG4667	esterase of the alpha-beta hydrolase superfamily
I6I39_RS05120	COG2823	Periplasmic or secreted lipoprotein
I6I39_RS05125	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
I6I39_RS05130	COG0456	acetyltransferase
I6I39_RS05135	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
I6I39_RS05140	COG2813	Specifically methylates the guanine in position
I6I39_RS05145	COG0667	Aldo Keto reductase
I6I39_RS05150	COG0583	DNA-binding transcription factor activity
I6I39_RS05175	COG4772	TonB-dependent receptor
I6I39_RS05210	COG3284	Transcriptional regulator
I6I39_RS05240	COG2192	nodulation
I6I39_RS05250	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6I39_RS05250	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
I6I39_RS05250	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I39_RS05255	COG1461	Dihydroxyacetone kinase
I6I39_RS05260	COG2376	Dihydroxyacetone kinase
I6I39_RS05270	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6I39_RS05275	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I39_RS05280	COG2235	arginine
I6I39_RS05295	COG0859	PFAM glycosyl transferase family 9
I6I39_RS05300	COG1070	Carbohydrate kinase
I6I39_RS05305	COG2390	Transcriptional regulator
I6I39_RS05315	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6I39_RS05320	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6I39_RS05325	COG1879	ABC-type sugar transport system periplasmic component
I6I39_RS05330	COG1830	Aldolase
I6I39_RS05335	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
I6I39_RS05380	COG0454	-acetyltransferase
I6I39_RS05435	COG0795	lipopolysaccharide-transporting ATPase activity
I6I39_RS05440	COG0795	lipopolysaccharide-transporting ATPase activity
I6I39_RS05445	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I6I39_RS05450	COG2927	DNA polymerase III (CHI subunit)
I6I39_RS05470	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
I6I39_RS05480	COG2731	YhcH YjgK YiaL family protein
I6I39_RS05490	COG0601	transmembrane transport
I6I39_RS05495	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I39_RS05500	COG0444	Belongs to the ABC transporter superfamily
I6I39_RS05505	COG4608	Belongs to the ABC transporter superfamily
I6I39_RS05535	COG2188	Transcriptional regulator
I6I39_RS05540	COG3624	Phosphonate C-P lyase system protein PhnG
I6I39_RS05545	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
I6I39_RS05555	COG3627	carbon phosphorus lyase activity
I6I39_RS05560	COG4107	phosphonate C-P lyase system protein PhnK
I6I39_RS05565	COG4778	phosphonate C-P lyase system protein PhnL
I6I39_RS05570	COG3454	Phosphonate metabolism
I6I39_RS05580	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I6I39_RS05585	COG0702	epimerase
I6I39_RS05600	COG3787	Belongs to the UPF0306 family
I6I39_RS05610	COG3842	ATPase activity
I6I39_RS05615	COG0395	ABC-type sugar transport system, permease component
I6I39_RS05620	COG1175	transmembrane transport
I6I39_RS05625	COG1653	transport
I6I39_RS05645	COG1982	Orn Lys Arg decarboxylase major
I6I39_RS05650	COG0531	amino acid
I6I39_RS05655	COG2827	Endonuclease containing a URI domain
I6I39_RS05660	COG3153	acetyltransferase
I6I39_RS05665	COG3154	lipid carrier protein
I6I39_RS05670	COG0826	peptidase U32
I6I39_RS05675	COG0826	peptidase U32
I6I39_RS05680	COG3681	Belongs to the UPF0597 family
I6I39_RS05685	COG0814	amino acid
I6I39_RS05695	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6I39_RS05705	COG0513	Belongs to the DEAD box helicase family
I6I39_RS05720	COG1185	polyribonucleotide nucleotidyltransferase activity
I6I39_RS05725	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I6I39_RS05730	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I6I39_RS05735	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I6I39_RS05740	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I6I39_RS05745	COG0195	Participates in both transcription termination and antitermination
I6I39_RS05750	COG0779	Required for maturation of 30S ribosomal subunits
I6I39_RS05765	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6I39_RS05770	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6I39_RS05775	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6I39_RS05785	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
I6I39_RS05790	COG1534	Rna-binding protein
I6I39_RS05800	COG2027	D-alanyl-D-alanine carboxypeptidase
I6I39_RS05805	COG0745	RESPONSE REGULATOR receiver
I6I39_RS05810	COG0642	Histidine kinase
I6I39_RS05815	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I6I39_RS05820	COG0697	spore germination
I6I39_RS05825	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I6I39_RS05830	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I6I39_RS05835	COG0142	geranyltranstransferase activity
I6I39_RS05845	COG3423	Transcriptional regulator
I6I39_RS05850	COG0039	L-malate dehydrogenase activity
I6I39_RS05855	COG1438	arginine binding
I6I39_RS05865	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6I39_RS05870	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
I6I39_RS05880	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I6I39_RS05885	COG2105	PFAM AIG2 family protein
I6I39_RS05890	COG2911	Protein conserved in bacteria
I6I39_RS05900	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6I39_RS05905	COG1253	flavin adenine dinucleotide binding
I6I39_RS05915	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
I6I39_RS05920	COG1218	3'(2'),5'-bisphosphate nucleotidase
I6I39_RS05925	COG0737	Belongs to the 5'-nucleotidase family
I6I39_RS05935	COG0545	Peptidyl-prolyl cis-trans isomerase
I6I39_RS05940	COG3061	Opacity-associated protein A
I6I39_RS05950	COG0359	binds to the 23S rRNA
I6I39_RS05955	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I6I39_RS05960	COG2965	DNA replication, synthesis of RNA primer
I6I39_RS05965	COG0360	Binds together with S18 to 16S ribosomal RNA
I6I39_RS05975	COG1073	alpha beta
I6I39_RS05980	COG3650	response to hydrogen peroxide
I6I39_RS05985	COG1960	acyl-CoA dehydrogenase activity
I6I39_RS05990	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6I39_RS05995	COG0557	exoribonuclease II activity
I6I39_RS06000	COG1959	2 iron, 2 sulfur cluster binding
I6I39_RS06005	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I6I39_RS06010	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
I6I39_RS06015	COG0330	HflC and HflK could
I6I39_RS06020	COG0330	HflC and HflK could
I6I39_RS06025	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6I39_RS06030	COG1923	regulation of RNA biosynthetic process
I6I39_RS06035	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I6I39_RS06040	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I6I39_RS06045	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6I39_RS06050	COG0802	atpase or kinase
I6I39_RS06055	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6I39_RS06055	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I6I39_RS06060	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I6I39_RS06080	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
I6I39_RS06085	COG1162	GTPase activity
I6I39_RS06090	COG0688	phosphatidylethanolamine metabolic process
I6I39_RS06095	COG3264	Mechanosensitive ion channel
I6I39_RS06095	COG1511	domain protein
I6I39_RS06100	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
I6I39_RS06105	COG1053	succinate dehydrogenase
I6I39_RS06110	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6I39_RS06115	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
I6I39_RS06120	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
I6I39_RS06140	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6I39_RS06155	COG0459	protein refolding
I6I39_RS06160	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I6I39_RS06175	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6I39_RS06185	COG4232	protein-disulfide reductase activity
I6I39_RS06190	COG1929	Belongs to the glycerate kinase type-1 family
I6I39_RS06195	COG1309	transcriptional regulator
I6I39_RS06205	COG1882	Formate acetyltransferase
I6I39_RS06210	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6I39_RS06215	COG0814	amino acid
I6I39_RS06220	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6I39_RS06230	COG3721	Heme iron utilization protein
I6I39_RS06250	COG3720	iron ion transport
I6I39_RS06255	COG4558	Periplasmic binding protein
I6I39_RS06260	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I39_RS06265	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
I6I39_RS06270	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I39_RS06280	COG4774	siderophore transport
I6I39_RS06285	COG1511	domain protein
I6I39_RS06285	COG3264	Mechanosensitive ion channel
I6I39_RS06290	COG4115	mRNA cleavage
I6I39_RS06295	COG2161	toxin-antitoxin pair type II binding
I6I39_RS06300	COG0612	Peptidase, M16
I6I39_RS06305	COG4178	(ABC) transporter
I6I39_RS06310	COG4771	TonB-dependent receptor
I6I39_RS06315	COG3712	iron ion homeostasis
I6I39_RS06330	COG0425	Belongs to the sulfur carrier protein TusA family
I6I39_RS06495	COG2197	response regulator
I6I39_RS06500	COG1301	dicarboxylic acid transport
I6I39_RS06505	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6I39_RS06510	COG3162	membrane
I6I39_RS06515	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6I39_RS06555	COG0138	bifunctional purine biosynthesis protein purh
I6I39_RS06560	COG0151	Belongs to the GarS family
I6I39_RS06580	COG1515	deoxyribonuclease V activity
I6I39_RS06585	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
I6I39_RS06590	COG2816	NAD+ diphosphatase activity
I6I39_RS06595	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
I6I39_RS06610	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6I39_RS06615	COG2104	thiamine diphosphate biosynthetic process
I6I39_RS06620	COG2022	thiamine diphosphate biosynthetic process
I6I39_RS06635	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I6I39_RS06640	COG0085	RNA polymerase activity
I6I39_RS06645	COG0222	ribosome binding
I6I39_RS06650	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I6I39_RS06655	COG0081	regulation of translation
I6I39_RS06660	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I6I39_RS06665	COG0250	Participates in transcription elongation, termination and antitermination
I6I39_RS06675	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6I39_RS06710	COG1072	(Pantothenic acid kinase))
I6I39_RS06715	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
I6I39_RS06715	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
I6I39_RS06760	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6I39_RS06765	COG1739	Uncharacterized protein family UPF0029
I6I39_RS06770	COG0006	proline dipeptidase activity
I6I39_RS06775	COG1024	Enoyl-CoA hydratase
I6I39_RS06775	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6I39_RS06780	COG0183	Belongs to the thiolase family
I6I39_RS06790	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I6I39_RS06810	COG0805	protein transport
I6I39_RS06815	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6I39_RS06820	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6I39_RS06825	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I6I39_RS06835	COG2226	methyltransferase
I6I39_RS06840	COG1322	Protein conserved in bacteria
I6I39_RS06845	COG0586	Pfam SNARE associated Golgi protein
I6I39_RS06850	COG1966	Carbon starvation protein
I6I39_RS06870	COG0412	Dienelactone hydrolase
I6I39_RS06875	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I6I39_RS06880	COG0583	DNA-binding transcription factor activity
I6I39_RS06885	COG0697	spore germination
I6I39_RS06890	COG0679	Auxin Efflux Carrier
I6I39_RS06895	COG0584	glycerophosphoryl diester phosphodiesterase
I6I39_RS06900	COG3842	ATPase activity
I6I39_RS06905	COG0395	ABC-type sugar transport system, permease component
I6I39_RS06910	COG1175	transmembrane transport
I6I39_RS06915	COG1653	transport
I6I39_RS06950	COG0410	ABC transporter
I6I39_RS06960	COG4177	L-phenylalanine transmembrane transporter activity
I6I39_RS06970	COG0683	leucine binding
I6I39_RS07000	COG2177	Part of the ABC transporter FtsEX involved in
I6I39_RS07005	COG2884	Cell division ATP-binding protein ftsE
I6I39_RS07010	COG0552	protein localization to endoplasmic reticulum
I6I39_RS07015	COG0742	ribosomal rna small subunit methyltransferase
I6I39_RS07020	COG3776	membrane
I6I39_RS07035	COG3714	YhhN family
I6I39_RS07040	COG2217	Heavy metal translocating P-type atpase
I6I39_RS07045	COG0425	Belongs to the sulfur carrier protein TusA family
I6I39_RS07050	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
I6I39_RS07060	COG0247	lactate metabolic process
I6I39_RS07065	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
I6I39_RS07070	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6I39_RS07080	COG2271	Major facilitator Superfamily
I6I39_RS07085	COG0584	glycerophosphoryl diester phosphodiesterase
I6I39_RS07095	COG0561	phosphatase activity
I6I39_RS07100	COG2267	carboxylic ester hydrolase activity
I6I39_RS07105	COG1280	lysine exporter protein (LysE YggA)
I6I39_RS07110	COG1280	lysine exporter protein (LysE YggA)
I6I39_RS07115	COG0514	ATP-dependent DNA helicase (RecQ)
I6I39_RS07120	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
I6I39_RS07125	COG2050	protein possibly involved in aromatic compounds catabolism
I6I39_RS07140	COG5564	TIM-barrel signal transduction protein
I6I39_RS07145	COG5441	Belongs to the UPF0261 family
I6I39_RS07155	COG0210	DNA helicase
I6I39_RS07160	COG1011	Hydrolase
I6I39_RS07165	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
I6I39_RS07170	COG3159	Protein conserved in bacteria
I6I39_RS07175	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I6I39_RS07185	COG1965	Belongs to the frataxin family
I6I39_RS07190	COG3072	Adenylate cyclase
I6I39_RS07195	COG0181	hydroxymethylbilane synthase activity
I6I39_RS07200	COG1587	Uroporphyrinogen-III synthase
I6I39_RS07205	COG2959	enzyme of heme biosynthesis
I6I39_RS07210	COG3071	HemY protein
I6I39_RS07255	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6I39_RS07260	COG2244	polysaccharide biosynthetic process
I6I39_RS07265	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6I39_RS07270	COG0456	acetyltransferase
I6I39_RS07275	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I6I39_RS07280	COG1088	dTDP-glucose 4,6-dehydratase activity
I6I39_RS07285	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I6I39_RS07290	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I6I39_RS07295	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
I6I39_RS07300	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6I39_RS07305	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I6I39_RS07310	COG3118	belongs to the thioredoxin family
I6I39_RS07320	COG0248	Ppx GppA phosphatase
I6I39_RS07335	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6I39_RS07345	COG3121	Chaperone
I6I39_RS07360	COG3121	Chaperone
I6I39_RS07385	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I6I39_RS07390	COG0583	DNA-binding transcription factor activity
I6I39_RS07410	COG0129	dihydroxy-acid dehydratase activity
I6I39_RS07415	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6I39_RS07420	COG3978	acetolactate synthase activity
I6I39_RS07440	COG3085	chromosome segregation
I6I39_RS07445	COG0583	DNA-binding transcription factor activity
I6I39_RS07450	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6I39_RS07455	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6I39_RS07460	COG1129	ABC transporter
I6I39_RS07465	COG1879	ABC-type sugar transport system periplasmic component
I6I39_RS07505	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I6I39_RS07515	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6I39_RS07525	COG1309	transcriptional regulator
I6I39_RS07530	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6I39_RS07540	COG0678	peroxiredoxin activity
I6I39_RS07540	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6I39_RS07545	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6I39_RS07585	COG1629	transport
I6I39_RS07590	COG0165	Argininosuccinate lyase
I6I39_RS07595	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6I39_RS07610	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
I6I39_RS07620	COG0527	aspartate kinase activity
I6I39_RS07620	COG0460	homoserine dehydrogenase
I6I39_RS07625	COG0626	cystathionine gamma-synthase activity
I6I39_RS07630	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
I6I39_RS07635	COG0254	rRNA binding
I6I39_RS07640	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6I39_RS07645	COG1609	Transcriptional regulator
I6I39_RS07650	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6I39_RS07655	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
I6I39_RS07660	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
I6I39_RS07665	COG1575	Belongs to the MenA family. Type 1 subfamily
I6I39_RS07670	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6I39_RS07675	COG3074	FtsZ-dependent cytokinesis
I6I39_RS07680	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6I39_RS07690	COG1494	fructose-1,6-bisphosphatase
I6I39_RS07700	COG2814	Major facilitator Superfamily
I6I39_RS07720	COG3152	Membrane
I6I39_RS07730	COG0149	triose-phosphate isomerase activity
I6I39_RS07740	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
I6I39_RS07750	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I6I39_RS07830	COG4695	Portal protein
I6I39_RS07845	COG0653	protein targeting
I6I39_RS07870	COG4974	Belongs to the 'phage' integrase family
I6I39_RS07875	COG3678	ATP-independent chaperone mediated protein folding
I6I39_RS07880	COG0745	RESPONSE REGULATOR receiver
I6I39_RS07885	COG2205	protein histidine kinase activity
I6I39_RS07890	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6I39_RS07890	COG2169	Transcriptional regulator
I6I39_RS07895	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I6I39_RS07900	COG1045	serine acetyltransferase
I6I39_RS07905	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I6I39_RS07910	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
I6I39_RS07915	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6I39_RS07920	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6I39_RS07925	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
I6I39_RS07930	COG4942	peptidase
I6I39_RS07935	COG2861	carbohydrate metabolic process
I6I39_RS07950	COG1063	alcohol dehydrogenase
I6I39_RS07955	COG0156	8-amino-7-oxononanoate synthase activity
I6I39_RS07960	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6I39_RS07965	COG0859	PFAM glycosyl transferase family 9
I6I39_RS07970	COG0859	PFAM glycosyl transferase family 9
I6I39_RS07975	COG1519	Transferase
I6I39_RS07985	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I6I39_RS07990	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6I39_RS07995	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6I39_RS08000	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I6I39_RS08005	COG2003	Belongs to the UPF0758 family
I6I39_RS08010	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6I39_RS08015	COG0756	dUTP diphosphatase activity
I6I39_RS08020	COG1309	transcriptional regulator
I6I39_RS08030	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I6I39_RS08035	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
I6I39_RS08040	COG1561	YicC-like family, N-terminal region
I6I39_RS08050	COG5001	Diguanylate cyclase
I6I39_RS08055	COG1024	Enoyl-CoA hydratase
I6I39_RS08060	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6I39_RS08070	COG2860	membrane
I6I39_RS08075	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6I39_RS08085	COG1758	RNA polymerase activity
I6I39_RS08090	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6I39_RS08095	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6I39_RS08100	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6I39_RS08110	COG0786	glutamate:sodium symporter activity
I6I39_RS08115	COG2233	PERMEase
I6I39_RS08120	COG2982	Protein involved in outer membrane biogenesis
I6I39_RS08140	COG3423	Transcriptional regulator
I6I39_RS08145	COG0456	acetyltransferase
I6I39_RS08150	COG1490	D-aminoacyl-tRNA deacylase activity
I6I39_RS08155	COG1295	ribonuclease BN
I6I39_RS08160	COG1011	Hydrolase
I6I39_RS08175	COG3852	Histidine kinase
I6I39_RS08185	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6I39_RS08190	COG3078	GTPase activator activity
I6I39_RS08195	COG0218	Necessary for normal cell division and for the maintenance of normal septation
I6I39_RS08200	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6I39_RS08200	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6I39_RS08205	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6I39_RS08210	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I6I39_RS08215	COG3084	Protein conserved in bacteria
I6I39_RS08225	COG1763	Mo-molybdopterin cofactor biosynthetic process
I6I39_RS08255	COG2186	Transcriptional regulator
I6I39_RS08260	COG0477	Major facilitator Superfamily
I6I39_RS08265	COG1609	Transcriptional regulator
I6I39_RS08270	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6I39_RS08275	COG1879	ABC-type sugar transport system periplasmic component
I6I39_RS08280	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6I39_RS08290	COG1869	D-ribose catabolic process
I6I39_RS08295	COG3158	transport of potassium into the cell
I6I39_RS08300	COG0714	Associated with various cellular activities
I6I39_RS08305	COG2425	protein containing a von Willebrand factor type A (vWA) domain
I6I39_RS08315	COG2502	aspartate--ammonia ligase
I6I39_RS08320	COG1522	sequence-specific DNA binding
I6I39_RS08325	COG0716	FMN binding
I6I39_RS08330	COG0445	tRNA wobble uridine modification
I6I39_RS08335	COG0357	Ribosomal RNA small subunit methyltransferase G
I6I39_RS08340	COG3312	ion transport
I6I39_RS08345	COG0356	it plays a direct role in the translocation of protons across the membrane
I6I39_RS08355	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I6I39_RS08360	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6I39_RS08365	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I6I39_RS08370	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I6I39_RS08375	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I6I39_RS08380	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I6I39_RS08385	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6I39_RS08395	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I6I39_RS08400	COG0573	inorganic phosphate transmembrane transporter activity
I6I39_RS08405	COG0581	inorganic phosphate transmembrane transporter activity
I6I39_RS08415	COG0704	Plays a role in the regulation of phosphate uptake
I6I39_RS08425	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I39_RS08430	COG0765	amino acid transport
I6I39_RS08435	COG0765	amino acid transport
I6I39_RS08440	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6I39_RS08445	COG2252	PERMEase
I6I39_RS08455	COG4566	intracellular signal transduction
I6I39_RS08465	COG0431	NADPH-dependent FMN reductase
I6I39_RS08470	COG0840	transmembrane signaling receptor activity
I6I39_RS08475	COG2011	ABC-type metal ion transport system permease component
I6I39_RS08490	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I6I39_RS08495	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
I6I39_RS08500	COG0706	membrane insertase activity
I6I39_RS08510	COG0594	ribonuclease P activity
I6I39_RS08515	COG0230	Belongs to the bacterial ribosomal protein bL34 family
I6I39_RS08520	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6I39_RS08525	COG0592	DNA-directed DNA polymerase activity
I6I39_RS08530	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6I39_RS08535	COG0187	DNA topoisomerase II activity
I6I39_RS08540	COG0561	phosphatase activity
I6I39_RS08545	COG2423	ornithine cyclodeaminase activity
I6I39_RS08555	COG0823	Involved in the tonB-independent uptake of proteins
I6I39_RS08560	COG5645	(Lipo)protein
I6I39_RS08575	COG2985	domain, Protein
I6I39_RS08575	COG0569	domain protein
I6I39_RS08580	COG3977	Valine--pyruvate aminotransferase
I6I39_RS08585	COG0366	Alpha amylase catalytic
I6I39_RS08590	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6I39_RS08620	COG0456	acetyltransferase
I6I39_RS08625	COG2818	Glycosylase
I6I39_RS08630	COG0752	glycyl-tRNA synthetase alpha subunit
I6I39_RS08635	COG0751	glycine-tRNA ligase activity
I6I39_RS08645	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I39_RS08645	COG2213	PTS system mannitol-specific
I6I39_RS08650	COG0246	Mannitol dehydrogenase
I6I39_RS08655	COG3722	fumarate hydratase activity
I6I39_RS08665	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I39_RS08685	COG2258	MOSC domain
I6I39_RS08690	COG0840	transmembrane signaling receptor activity
I6I39_RS08695	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6I39_RS08700	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I6I39_RS08710	COG0437	4 iron, 4 sulfur cluster binding
I6I39_RS08715	COG2864	formate dehydrogenase
I6I39_RS08720	COG3058	Necessary for formate dehydrogenase activity
I6I39_RS08725	COG1921	L-seryl-tRNASec selenium transferase activity
I6I39_RS08730	COG3276	selenocysteine insertion sequence binding
I6I39_RS08740	COG3274	enterobacterial common antigen metabolic process
I6I39_RS08755	COG3121	Chaperone
I6I39_RS08760	COG1070	Carbohydrate kinase
I6I39_RS08765	COG2115	Belongs to the xylose isomerase family
I6I39_RS08770	COG4213	ABC transporter substrate-binding protein
I6I39_RS08780	COG4214	carbohydrate transport
I6I39_RS08795	COG0582	viral genome integration into host DNA
I6I39_RS08835	COG2986	histidine ammonia-lyase
I6I39_RS08840	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
I6I39_RS08865	COG1482	cell wall glycoprotein biosynthetic process
I6I39_RS08870	COG2723	6-phospho-beta-galactosidase activity
I6I39_RS08885	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6I39_RS08890	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6I39_RS08895	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6I39_RS08900	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6I39_RS08905	COG1940	carbohydrate kinase activity
I6I39_RS08910	COG1609	Transcriptional regulator
I6I39_RS08935	COG3328	transposase activity
I6I39_RS08945	COG3210	domain, Protein
I6I39_RS08950	COG2831	hemolysin activation secretion protein
I6I39_RS08965	COG2271	Major facilitator Superfamily
I6I39_RS08970	COG3851	Histidine kinase
I6I39_RS08975	COG2197	response regulator
I6I39_RS08980	COG2194	sulfuric ester hydrolase activity
I6I39_RS08985	COG1764	response to oxidative stress
I6I39_RS08995	COG0747	negative chemotaxis
I6I39_RS09000	COG0601	transmembrane transport
I6I39_RS09005	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I39_RS09010	COG0444	Belongs to the ABC transporter superfamily
I6I39_RS09015	COG4608	Belongs to the ABC transporter superfamily
I6I39_RS09020	COG2194	sulfuric ester hydrolase activity
I6I39_RS09040	COG1192	Involved in chromosome partitioning
I6I39_RS09045	COG1215	transferase activity, transferring glycosyl groups
I6I39_RS09050	COG1215	transferase activity, transferring glycosyl groups
I6I39_RS09055	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
I6I39_RS09060	COG0457	Tetratricopeptide repeat
I6I39_RS09060	COG3118	belongs to the thioredoxin family
I6I39_RS09065	COG2200	EAL domain
I6I39_RS09065	COG2199	diguanylate cyclase activity
I6I39_RS09070	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
I6I39_RS09085	COG1301	dicarboxylic acid transport
I6I39_RS09090	COG0612	Peptidase, M16
I6I39_RS09095	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6I39_RS09100	COG1942	4-Oxalocrotonate Tautomerase
I6I39_RS09105	COG2200	EAL domain
I6I39_RS09110	COG2982	Protein involved in outer membrane biogenesis
I6I39_RS09115	COG2134	cdp-diacylglycerol pyrophosphatase
I6I39_RS09120	COG1295	ribonuclease BN
I6I39_RS09130	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6I39_RS09135	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I6I39_RS09145	COG0742	ribosomal rna small subunit methyltransferase
I6I39_RS09160	COG0589	response to stress
I6I39_RS09170	COG0306	phosphate transporter
I6I39_RS09175	COG2081	HI0933 family
I6I39_RS09180	COG1301	dicarboxylic acid transport
I6I39_RS09195	COG3799	methylaspartate ammonia-lyase activity
I6I39_RS09200	COG4865	methylaspartate mutase activity
I6I39_RS09210	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I6I39_RS09220	COG1648	precorrin-2 dehydrogenase activity
I6I39_RS09220	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6I39_RS09225	COG0583	DNA-binding transcription factor activity
I6I39_RS09230	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I6I39_RS09230	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6I39_RS09240	COG0561	phosphatase activity
I6I39_RS09250	COG0583	DNA-binding transcription factor activity
I6I39_RS09255	COG2814	Major facilitator Superfamily
I6I39_RS09265	COG3718	enzyme involved in inositol metabolism
I6I39_RS09275	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6I39_RS09285	COG0673	inositol 2-dehydrogenase activity
I6I39_RS09290	COG1082	Xylose isomerase domain protein TIM barrel
I6I39_RS09295	COG1247	-acetyltransferase
I6I39_RS09300	COG1741	Belongs to the pirin family
I6I39_RS09305	COG1609	Transcriptional regulator
I6I39_RS09310	COG2610	gluconate transmembrane transporter activity
I6I39_RS09315	COG3265	gluconokinase activity
I6I39_RS09320	COG2095	MarC family integral membrane protein
I6I39_RS09325	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6I39_RS09345	COG3275	phosphorelay sensor kinase activity
I6I39_RS09350	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I6I39_RS09355	COG1523	belongs to the glycosyl hydrolase 13 family
I6I39_RS09365	COG0297	glycogen (starch) synthase activity
I6I39_RS09370	COG0058	SHG alpha-glucan phosphorylase activity
I6I39_RS09375	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6I39_RS09385	COG1349	DNA-binding transcription factor activity
I6I39_RS09390	COG0705	Rhomboid family
I6I39_RS09405	COG2909	trisaccharide binding
I6I39_RS09410	COG0058	SHG alpha-glucan phosphorylase activity
I6I39_RS09415	COG1640	4-alpha-glucanotransferase
I6I39_RS09425	COG0316	Belongs to the HesB IscA family
I6I39_RS09425	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
I6I39_RS09435	COG0596	Alpha beta hydrolase
I6I39_RS09450	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
I6I39_RS09455	COG1918	ferrous iron import across plasma membrane
I6I39_RS09460	COG2183	response to ionizing radiation
I6I39_RS09485	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6I39_RS09500	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
I6I39_RS09510	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I6I39_RS09515	COG1011	Hydrolase
I6I39_RS09525	COG0494	nUDIX hydrolase
I6I39_RS09530	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
I6I39_RS09555	COG4796	Type ii and iii secretion system protein
I6I39_RS09560	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6I39_RS09580	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6I39_RS09590	COG0180	Tryptophanyl-tRNA synthetase
I6I39_RS09595	COG1648	precorrin-2 dehydrogenase activity
I6I39_RS09595	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6I39_RS09610	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6I39_RS09615	COG0402	S-adenosylhomocysteine deaminase activity
I6I39_RS09620	COG0738	Major facilitator superfamily
I6I39_RS09630	COG1486	melibiose metabolic process
I6I39_RS09635	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6I39_RS09640	COG0433	COG0433 Predicted ATPase
I6I39_RS09655	COG1289	transmembrane transporter activity
I6I39_RS09665	COG1765	OsmC-like protein
I6I39_RS09670	COG3954	Phosphoribulokinase
I6I39_RS09675	COG3089	Belongs to the UPF0270 family
I6I39_RS09680	COG0429	hydrolase of the alpha beta-hydrolase fold
I6I39_RS09695	COG4521	taurine ABC transporter
I6I39_RS09705	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6I39_RS09710	COG2175	clavaminate synthase activity
I6I39_RS09720	COG1216	Glycosyl transferase, family 2
I6I39_RS09725	COG0488	(ABC) transporter
I6I39_RS09730	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6I39_RS09740	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
I6I39_RS09745	COG1047	Peptidyl-prolyl cis-trans
I6I39_RS09750	COG2900	Belongs to the SlyX family
I6I39_RS09755	COG0545	Peptidyl-prolyl cis-trans isomerase
I6I39_RS09760	COG2964	Protein conserved in bacteria
I6I39_RS09765	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
I6I39_RS09770	COG2923	Belongs to the DsrF TusC family
I6I39_RS09775	COG2168	tRNA wobble position uridine thiolation
I6I39_RS09780	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I6I39_RS09785	COG0049	tRNA binding
I6I39_RS09795	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6I39_RS09810	COG0051	transcription antitermination factor activity, RNA binding
I6I39_RS09815	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I6I39_RS09820	COG0088	Forms part of the polypeptide exit tunnel
I6I39_RS09825	COG0089	rRNA binding
I6I39_RS09830	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I6I39_RS09835	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I6I39_RS09840	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I6I39_RS09845	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I6I39_RS09850	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I6I39_RS09855	COG0255	Belongs to the universal ribosomal protein uL29 family
I6I39_RS09860	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I6I39_RS09865	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I6I39_RS09870	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I6I39_RS09875	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I6I39_RS09880	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I6I39_RS09890	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I6I39_RS09895	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I6I39_RS09900	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I6I39_RS09905	COG1841	ribosomal large subunit assembly
I6I39_RS09910	COG0200	Binds to the 23S rRNA
I6I39_RS09915	COG0201	protein transport
I6I39_RS09920	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6I39_RS09925	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I6I39_RS09930	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I6I39_RS09935	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I6I39_RS09940	COG0202	RNA polymerase activity
I6I39_RS09945	COG0203	ribosomal protein L17
I6I39_RS09955	COG0789	Transcriptional regulator
I6I39_RS09960	COG3036	rescue of stalled ribosome
I6I39_RS09975	COG1970	mechanosensitive ion channel activity
I6I39_RS09985	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6I39_RS09985	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6I39_RS09990	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I6I39_RS09995	COG0242	peptide deformylase activity
I6I39_RS10000	COG0758	DNA mediated transformation
I6I39_RS10010	COG0551	DNA topoisomerase type I activity
I6I39_RS10015	COG0009	L-threonylcarbamoyladenylate synthase
I6I39_RS10020	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6I39_RS10025	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6I39_RS10065	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
I6I39_RS10070	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I6I39_RS10075	COG2224	Isocitrate lyase
I6I39_RS10080	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
I6I39_RS10085	COG1414	Transcriptional regulator
I6I39_RS10110	COG0527	aspartate kinase activity
I6I39_RS10115	COG0166	Belongs to the GPI family
I6I39_RS10125	COG3833	ABC-type maltose transport systems, permease component
I6I39_RS10130	COG1175	transmembrane transport
I6I39_RS10135	COG2182	Extracellular solute-binding protein
I6I39_RS10150	COG4580	involved in the transport of maltose and maltodextrins
I6I39_RS10165	COG3161	chorismate lyase activity
I6I39_RS10170	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I6I39_RS10175	COG2937	Belongs to the GPAT DAPAT family
I6I39_RS10180	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I6I39_RS10185	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6I39_RS10190	COG3237	CsbD-like
I6I39_RS10195	COG0735	belongs to the Fur family
I6I39_RS10200	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I6I39_RS10200	COG2755	lipolytic protein G-D-S-L family
I6I39_RS10205	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6I39_RS10235	COG1448	Aminotransferase
I6I39_RS10240	COG2315	Protein conserved in bacteria
I6I39_RS10245	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6I39_RS10255	COG3550	peptidyl-serine autophosphorylation
I6I39_RS10270	COG2252	PERMEase
I6I39_RS10275	COG0025	NhaP-type Na H and K H
I6I39_RS10280	COG0583	DNA-binding transcription factor activity
I6I39_RS10285	COG1380	Effector of murein hydrolase LrgA
I6I39_RS10295	COG1126	abc transporter atp-binding protein
I6I39_RS10300	COG0765	amino acid transport
I6I39_RS10305	COG4597	amino acid ABC transporter
I6I39_RS10310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I39_RS10325	COG1560	Kdo2-lipid A biosynthetic process
I6I39_RS10330	COG0471	metal ion transport
I6I39_RS10335	COG1278	Cold shock
I6I39_RS10340	COG1278	Cold shock
I6I39_RS10345	COG3133	Outer membrane lipoprotein
I6I39_RS10355	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
I6I39_RS10360	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6I39_RS10365	COG2264	protein methyltransferase activity
I6I39_RS10370	COG4145	pantothenate transmembrane transporter activity
I6I39_RS10375	COG3924	membrane
I6I39_RS10380	COG0439	Biotin carboxylase
I6I39_RS10385	COG0511	ligase activity, forming carbon-carbon bonds
I6I39_RS10390	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I6I39_RS10395	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
I6I39_RS10405	COG0604	alcohol dehydrogenase
I6I39_RS10410	COG2199	diguanylate cyclase activity
I6I39_RS10410	COG2200	EAL domain
I6I39_RS10415	COG1077	Cell shape determining protein MreB Mrl
I6I39_RS10420	COG1792	Involved in formation and maintenance of cell shape
I6I39_RS10425	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
I6I39_RS10430	COG0424	maF-like protein
I6I39_RS10440	COG3164	Protein of unknown function
I6I39_RS10445	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6I39_RS10450	COG0312	modulator of DNA gyrase
I6I39_RS10510	COG0583	DNA-binding transcription factor activity
I6I39_RS10520	COG1566	PFAM secretion protein HlyD family protein
I6I39_RS10525	COG1289	transmembrane transporter activity
I6I39_RS10540	COG2732	(Barnase) inhibitor
I6I39_RS10545	COG3028	Belongs to the UPF0307 family
I6I39_RS10550	COG0312	modulator of DNA gyrase
I6I39_RS10555	COG3783	Cytochrome b(562)
I6I39_RS10560	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6I39_RS10590	COG3964	amidohydrolase
I6I39_RS10605	COG2706	6-phosphogluconolactonase activity
I6I39_RS10610	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I39_RS10610	COG3711	transcriptional antiterminator
I6I39_RS10615	COG3093	addiction module antidote protein HigA
I6I39_RS10625	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I6I39_RS10635	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I39_RS10635	COG1263	PTS System
I6I39_RS10640	COG0366	Alpha amylase catalytic
I6I39_RS10660	COG2308	Evidence 4 Homologs of previously reported genes of
I6I39_RS10670	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
I6I39_RS10675	COG0540	Belongs to the ATCase OTCase family
I6I39_RS10680	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I39_RS10685	COG1660	Displays ATPase and GTPase activities
I6I39_RS10700	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I6I39_RS10705	COG1137	ATPase activity
I6I39_RS10710	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
I6I39_RS10715	COG3117	lipopolysaccharide transmembrane transporter activity
I6I39_RS10720	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I6I39_RS10725	COG0517	IMP dehydrogenase activity
I6I39_RS10725	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I6I39_RS10730	COG0530	calcium, potassium:sodium antiporter activity
I6I39_RS10735	COG1127	ABC transporter
I6I39_RS10740	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6I39_RS10745	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6I39_RS10750	COG2854	intermembrane phospholipid transfer
I6I39_RS10755	COG3113	response to antibiotic
I6I39_RS10760	COG5007	Belongs to the BolA IbaG family
I6I39_RS10765	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6I39_RS10770	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6I39_RS10775	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6I39_RS10780	COG3105	Protein conserved in bacteria
I6I39_RS10785	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I6I39_RS10790	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I6I39_RS10795	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I6I39_RS10800	COG0625	glutathione transferase activity
I6I39_RS10805	COG2969	positive regulation of protein catabolic process
I6I39_RS10815	COG0493	'glutamate synthase
I6I39_RS10820	COG0067	glutamate synthase
I6I39_RS10820	COG0069	glutamate synthase activity
I6I39_RS10820	COG0070	glutamate synthase
I6I39_RS10825	COG1242	4 iron, 4 sulfur cluster binding
I6I39_RS10830	COG5002	protein histidine kinase activity
I6I39_RS10830	COG0784	Response regulator, receiver
I6I39_RS10830	COG2198	Histidine kinase
I6I39_RS10835	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
I6I39_RS10840	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6I39_RS10850	COG2823	Periplasmic or secreted lipoprotein
I6I39_RS10855	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
I6I39_RS10860	COG0792	nuclease activity
I6I39_RS10870	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I6I39_RS10915	COG3121	Chaperone
I6I39_RS10935	COG0667	Aldo Keto reductase
I6I39_RS10945	COG1741	Belongs to the pirin family
I6I39_RS10950	COG0583	DNA-binding transcription factor activity
I6I39_RS10955	COG0435	Glutathione S-transferase
I6I39_RS10960	COG2259	Doxx family
I6I39_RS10970	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
I6I39_RS10975	COG4575	ribosome binding
I6I39_RS10990	COG0586	Pfam SNARE associated Golgi protein
I6I39_RS11005	COG2271	Major facilitator Superfamily
I6I39_RS11010	COG1904	glucuronate isomerase
I6I39_RS11015	COG0246	Mannitol dehydrogenase
I6I39_RS11020	COG2721	sulfolactate sulfo-lyase activity
I6I39_RS11030	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
I6I39_RS11035	COG0861	Integral membrane protein TerC family
I6I39_RS11040	COG0673	inositol 2-dehydrogenase activity
I6I39_RS11045	COG1451	nucleotide metabolic process
I6I39_RS11065	COG2813	Specifically methylates the guanine in position
I6I39_RS11070	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6I39_RS11070	COG1902	pentaerythritol trinitrate reductase activity
I6I39_RS11080	COG3247	response to pH
I6I39_RS11085	COG0076	glutamate decarboxylase activity
I6I39_RS11090	COG0531	amino acid
I6I39_RS11100	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I39_RS11100	COG1263	PTS System
I6I39_RS11105	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
I6I39_RS11115	COG1472	Belongs to the glycosyl hydrolase 3 family
I6I39_RS11125	COG3876	Protein conserved in bacteria
I6I39_RS11130	COG4974	Belongs to the 'phage' integrase family
I6I39_RS11185	COG4695	Portal protein
I6I39_RS11325	COG0358	DNA primase activity
I6I39_RS11330	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I6I39_RS11335	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I6I39_RS11340	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
I6I39_RS11345	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6I39_RS11350	COG1968	undecaprenyl-diphosphatase activity
I6I39_RS11355	COG0617	tRNA 3'-terminal CCA addition
I6I39_RS11360	COG4991	sh3 domain protein
I6I39_RS11365	COG3025	triphosphatase activity
I6I39_RS11370	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
I6I39_RS11375	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I6I39_RS11375	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
I6I39_RS11380	COG0531	amino acid
I6I39_RS11390	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6I39_RS11395	COG3384	dioxygenase
I6I39_RS11400	COG0754	glutathionylspermidine amidase activity
I6I39_RS11405	COG5463	Belongs to the UPF0441 family
I6I39_RS11410	COG1538	Outer membrane efflux protein
I6I39_RS11415	COG0494	nUDIX hydrolase
I6I39_RS11420	COG3151	Protein conserved in bacteria
I6I39_RS11430	COG3150	esterase
I6I39_RS11445	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
I6I39_RS11450	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6I39_RS11455	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6I39_RS11465	COG2132	Multicopper oxidase
I6I39_RS11475	COG0656	L-ascorbic acid biosynthetic process
I6I39_RS11480	COG1979	alcohol dehydrogenase
I6I39_RS11485	COG2207	Transcriptional regulator
I6I39_RS11490	COG0586	Pfam SNARE associated Golgi protein
I6I39_RS11495	COG0626	cystathionine gamma-synthase activity
I6I39_RS11505	COG0848	biopolymer transport protein
I6I39_RS11555	COG4964	Belongs to the GSP D family
I6I39_RS11640	COG0577	efflux transmembrane transporter activity
I6I39_RS11640	COG1136	(ABC) transporter
I6I39_RS11675	COG1815	bacterial-type flagellum-dependent cell motility
I6I39_RS11680	COG1558	bacterial-type flagellum-dependent cell motility
I6I39_RS11685	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
I6I39_RS11700	COG4786	Flagellar basal body rod
I6I39_RS11710	COG1706	bacterial-type flagellum-dependent cell motility
I6I39_RS11740	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I6I39_RS11745	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
I6I39_RS11750	COG1516	flagellar protein fliS
I6I39_RS11770	COG1191	sigma factor activity
I6I39_RS11775	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I6I39_RS11785	COG3133	Outer membrane lipoprotein
I6I39_RS11790	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
I6I39_RS11795	COG0437	4 iron, 4 sulfur cluster binding
I6I39_RS11800	COG5557	Pfam Polysulphide reductase, NrfD
I6I39_RS11805	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
I6I39_RS11810	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I6I39_RS11815	COG1773	rubredoxin
I6I39_RS11825	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I6I39_RS11830	COG0298	carbon dioxide binding
I6I39_RS11835	COG0409	Hydrogenase expression formation protein
I6I39_RS11840	COG0309	Hydrogenase expression formation protein (HypE)
I6I39_RS11845	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
I6I39_RS11855	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
I6I39_RS11865	COG5001	Diguanylate cyclase
I6I39_RS11880	COG0477	Major facilitator Superfamily
I6I39_RS11895	COG1283	sodium-dependent phosphate transmembrane transporter activity
I6I39_RS11905	COG1609	Transcriptional regulator
I6I39_RS11910	COG0477	Major facilitator Superfamily
I6I39_RS11915	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I39_RS11920	COG0697	spore germination
I6I39_RS11935	COG4607	ABC-type enterochelin transport system periplasmic component
I6I39_RS11945	COG4605	iron ion homeostasis
I6I39_RS11950	COG4604	ABC transporter, ATP-binding protein
I6I39_RS11955	COG0024	Methionine aminopeptidase
I6I39_RS11980	COG1289	transmembrane transporter activity
I6I39_RS11995	COG1982	Orn Lys Arg decarboxylase major
I6I39_RS12000	COG0531	amino acid
I6I39_RS12045	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
I6I39_RS12055	COG1982	Orn Lys Arg decarboxylase major
I6I39_RS12065	COG0741	lytic transglycosylase activity
I6I39_RS12070	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
I6I39_RS12075	COG1194	a g-specific adenine glycosylase
I6I39_RS12080	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I6I39_RS12085	COG3171	Protein conserved in bacteria
I6I39_RS12100	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6I39_RS12105	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I6I39_RS12110	COG1872	DUF167
I6I39_RS12115	COG0762	integral membrane protein
I6I39_RS12120	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6I39_RS12125	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6I39_RS12130	COG2805	Type II/IV secretion system protein
I6I39_RS12140	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6I39_RS12145	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I6I39_RS12150	COG1678	Uncharacterized ACR, COG1678
I6I39_RS12155	COG0189	ligase activity
I6I39_RS12160	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6I39_RS12165	COG2356	endonuclease I
I6I39_RS12170	COG3091	SprT-like family
I6I39_RS12175	COG0640	Transcriptional regulator
I6I39_RS12190	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I6I39_RS12195	COG1166	arginine decarboxylase activity
I6I39_RS12205	COG0501	Belongs to the peptidase M48B family
I6I39_RS12210	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6I39_RS12215	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6I39_RS12220	COG0126	phosphoglycerate kinase activity
I6I39_RS12225	COG0191	fructose-bisphosphate aldolase activity
I6I39_RS12245	COG1279	arginine transmembrane transporter activity
I6I39_RS12255	COG0583	DNA-binding transcription factor activity
I6I39_RS12260	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
I6I39_RS12265	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6I39_RS12300	COG0602	queuosine metabolic process
I6I39_RS12320	COG0720	synthase
I6I39_RS12325	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I6I39_RS12330	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6I39_RS12335	COG0175	sulfate reduction
I6I39_RS12350	COG2234	aminopeptidase activity
I6I39_RS12355	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6I39_RS12355	COG1648	precorrin-2 dehydrogenase activity
I6I39_RS12360	COG0175	sulfate reduction
I6I39_RS12365	COG2895	sulfate adenylyltransferase (ATP) activity
I6I39_RS12370	COG0529	Catalyzes the synthesis of activated sulfate
I6I39_RS12380	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
I6I39_RS12390	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
I6I39_RS12395	COG0585	pseudouridine synthase activity
I6I39_RS12400	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
I6I39_RS12405	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
I6I39_RS12410	COG1388	LysM domain
I6I39_RS12410	COG4942	peptidase
I6I39_RS12415	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6I39_RS12420	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I6I39_RS12445	COG3188	usher protein
I6I39_RS12450	COG3121	Chaperone
I6I39_RS12460	COG3539	Fimbrial protein
I6I39_RS12465	COG3539	Fimbrial protein
I6I39_RS12495	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I39_RS12505	COG1538	Outer membrane efflux protein
I6I39_RS12525	COG1028	Short-chain dehydrogenase reductase Sdr
I6I39_RS12535	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6I39_RS12540	COG1858	cytochrome C peroxidase
I6I39_RS12550	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6I39_RS12555	COG0640	Transcriptional regulator
I6I39_RS12610	COG0410	ABC transporter
I6I39_RS12615	COG1137	ATPase activity
I6I39_RS12620	COG4177	L-phenylalanine transmembrane transporter activity
I6I39_RS12635	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I6I39_RS12635	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6I39_RS12640	COG0243	molybdopterin cofactor binding
I6I39_RS12645	COG0437	4 iron, 4 sulfur cluster binding
I6I39_RS12650	COG3302	dmso reductase anchor subunit
I6I39_RS12655	COG3381	protein complex oligomerization
I6I39_RS12675	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I6I39_RS12680	COG2137	regulation of response to DNA damage stimulus
I6I39_RS12685	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6I39_RS12690	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
I6I39_RS12715	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6I39_RS12720	COG1238	metal cluster binding
I6I39_RS12725	COG2918	glutathione biosynthetic process
I6I39_RS12730	COG1854	S-ribosylhomocysteine lyase activity
I6I39_RS12735	COG4536	flavin adenine dinucleotide binding
I6I39_RS12740	COG4137	Cytochrome C assembly protein
I6I39_RS12745	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6I39_RS12750	COG0228	four-way junction DNA binding
I6I39_RS12755	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I6I39_RS12760	COG0336	Belongs to the RNA methyltransferase TrmD family
I6I39_RS12765	COG0335	large ribosomal subunit rRNA binding
I6I39_RS12770	COG3137	Salt-induced outer membrane protein
I6I39_RS12775	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6I39_RS12780	COG3279	Response regulator of the LytR AlgR family
I6I39_RS12785	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6I39_RS12790	COG0287	Prephenate dehydrogenase
I6I39_RS12790	COG1605	Chorismate mutase
I6I39_RS12795	COG0077	Prephenate dehydratase
I6I39_RS12795	COG1605	Chorismate mutase
I6I39_RS12805	COG0542	response to heat
I6I39_RS12815	COG0564	pseudouridine synthase activity
I6I39_RS12820	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6I39_RS12825	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I6I39_RS12850	COG5544	Lipoprotein
I6I39_RS12855	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6I39_RS12860	COG0045	succinate-CoA ligase (ADP-forming) activity
I6I39_RS12860	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6I39_RS12860	COG1042	CoA-binding domain protein
I6I39_RS12865	COG3148	PFAM DTW domain containing protein
I6I39_RS12870	COG3118	belongs to the thioredoxin family
I6I39_RS12875	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6I39_RS12885	COG2814	Major facilitator Superfamily
I6I39_RS12890	COG1566	PFAM secretion protein HlyD family protein
I6I39_RS12895	COG1538	Outer membrane efflux protein
I6I39_RS12900	COG1846	Transcriptional regulator
I6I39_RS12910	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I6I39_RS12915	COG2814	Major facilitator Superfamily
I6I39_RS12955	COG0765	amino acid transport
I6I39_RS12960	COG0765	amino acid transport
I6I39_RS12970	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I6I39_RS12985	COG0436	Aminotransferase
I6I39_RS12990	COG0235	Class ii aldolase
I6I39_RS12995	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
I6I39_RS13000	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
I6I39_RS13005	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
I6I39_RS13010	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
I6I39_RS13015	COG2831	hemolysin activation secretion protein
I6I39_RS13030	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
I6I39_RS13035	COG1960	acyl-CoA dehydrogenase activity
I6I39_RS13045	COG0121	glutamine amidotransferase
I6I39_RS13050	COG3034	peptidoglycan biosynthetic process
I6I39_RS13055	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6I39_RS13060	COG1805	sodium ion transport
I6I39_RS13065	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6I39_RS13070	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6I39_RS13075	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6I39_RS13080	COG2871	sodium ion transport
I6I39_RS13085	COG1477	protein flavinylation
I6I39_RS13090	COG2991	Protein conserved in bacteria
I6I39_RS13100	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6I39_RS13105	COG2964	Protein conserved in bacteria
I6I39_RS13120	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6I39_RS13125	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6I39_RS13130	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
I6I39_RS13135	COG1073	alpha beta
I6I39_RS13145	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I6I39_RS13150	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I6I39_RS13155	COG2188	Transcriptional regulator
I6I39_RS13175	COG3459	Glycosyltransferase 36 associated
I6I39_RS13190	COG2226	methyltransferase
I6I39_RS13215	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6I39_RS13220	COG3123	guanosine phosphorylase activity
I6I39_RS13225	COG2974	May be involved in recombination
I6I39_RS13230	COG1940	carbohydrate kinase activity
I6I39_RS13235	COG0419	ATPase involved in DNA repair
I6I39_RS13240	COG0420	3'-5' exonuclease activity
I6I39_RS13245	COG0745	RESPONSE REGULATOR receiver
I6I39_RS13250	COG5002	protein histidine kinase activity
I6I39_RS13270	COG0366	Alpha amylase catalytic
I6I39_RS13290	COG0450	alkyl hydroperoxide reductase
I6I39_RS13295	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
I6I39_RS13300	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I6I39_RS13315	COG0343	queuine tRNA-ribosyltransferase activity
I6I39_RS13320	COG1862	Preprotein translocase
I6I39_RS13325	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6I39_RS13330	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6I39_RS13345	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I6I39_RS13350	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6I39_RS13350	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6I39_RS13355	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I6I39_RS13360	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6I39_RS13365	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I6I39_RS13370	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I6I39_RS13380	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I6I39_RS13385	COG0142	geranyltranstransferase activity
I6I39_RS13395	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6I39_RS13395	COG0301	tRNA thio-modification
I6I39_RS13405	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I6I39_RS13410	COG1666	GTP binding
I6I39_RS13415	COG2814	Major facilitator Superfamily
I6I39_RS13420	COG0109	protoheme IX farnesyltransferase activity
I6I39_RS13425	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I6I39_RS13430	COG1845	cytochrome c oxidase, subunit III
I6I39_RS13435	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6I39_RS13440	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I6I39_RS13450	COG2223	nitrite transmembrane transporter activity
I6I39_RS13455	COG3056	Lipoprotein
I6I39_RS13460	COG0271	Belongs to the BolA IbaG family
I6I39_RS13465	COG0544	peptidyl-prolyl cis-trans isomerase activity
I6I39_RS13470	COG0740	serine-type endopeptidase activity
I6I39_RS13475	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I6I39_RS13480	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I6I39_RS13485	COG0776	regulation of translation
I6I39_RS13490	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6I39_RS13495	COG1555	photosystem II stabilization
I6I39_RS13500	COG0824	Thioesterase
I6I39_RS13505	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
I6I39_RS13510	COG4533	DNA binding
I6I39_RS13515	COG0561	phosphatase activity
I6I39_RS13525	COG1522	sequence-specific DNA binding
I6I39_RS13530	COG1132	(ABC) transporter
I6I39_RS13535	COG1132	(ABC) transporter
I6I39_RS13540	COG0347	Belongs to the P(II) protein family
I6I39_RS13545	COG0004	ammonium transporteR
I6I39_RS13550	COG1946	Acyl-CoA thioesterase
I6I39_RS13555	COG3126	Type III secretion system lipoprotein chaperone (YscW)
I6I39_RS13560	COG3695	enzyme binding
I6I39_RS13590	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6I39_RS13595	COG0803	Belongs to the bacterial solute-binding protein 9 family
I6I39_RS13600	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6I39_RS13605	COG0254	rRNA binding
I6I39_RS13620	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
I6I39_RS13625	COG3457	Alanine racemase
I6I39_RS13640	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6I39_RS13645	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I39_RS13650	COG1309	transcriptional regulator
I6I39_RS13655	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
I6I39_RS13660	COG3264	Mechanosensitive ion channel
I6I39_RS13660	COG1196	nuclear chromosome segregation
I6I39_RS13675	COG2832	Protein of unknown function (DUF454)
I6I39_RS13680	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6I39_RS13690	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
I6I39_RS13695	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I6I39_RS13700	COG0326	Molecular chaperone. Has ATPase activity
I6I39_RS13705	COG0563	adenylate kinase activity
I6I39_RS13710	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I6I39_RS13715	COG2244	polysaccharide biosynthetic process
I6I39_RS13720	COG1216	Glycosyl transferase, family 2
I6I39_RS13720	COG1442	glycosyl transferase family 8
I6I39_RS13725	COG1215	transferase activity, transferring glycosyl groups
I6I39_RS13730	COG0438	transferase activity, transferring glycosyl groups
I6I39_RS13735	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6I39_RS13740	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6I39_RS13760	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6I39_RS13765	COG4651	solute:proton antiporter activity
I6I39_RS13765	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6I39_RS13770	COG2223	nitrite transmembrane transporter activity
I6I39_RS13775	COG0737	Belongs to the 5'-nucleotidase family
I6I39_RS13780	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6I39_RS13785	COG3735	TraB family
I6I39_RS13790	COG2217	Heavy metal translocating P-type atpase
I6I39_RS13795	COG0789	Transcriptional regulator
I6I39_RS13800	COG1585	Membrane protein implicated in regulation of membrane protease activity
I6I39_RS13805	COG0330	HflC and HflK could
I6I39_RS13810	COG3118	belongs to the thioredoxin family
I6I39_RS13815	COG0300	oxidoreductase activity
I6I39_RS13820	COG2755	lipolytic protein G-D-S-L family
I6I39_RS13825	COG4181	ATPase activity
I6I39_RS13830	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I6I39_RS13835	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I6I39_RS13840	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I6I39_RS13845	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6I39_RS13850	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6I39_RS13855	COG0215	cysteine-tRNA ligase activity
I6I39_RS13860	COG2501	S4 domain
I6I39_RS13865	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I6I39_RS13950	COG2850	peptidyl-arginine hydroxylation
I6I39_RS13955	COG2986	histidine ammonia-lyase
I6I39_RS13970	COG5265	(ABC) transporter
I6I39_RS13985	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6I39_RS13995	COG2197	response regulator
I6I39_RS14000	COG1278	Cold shock
I6I39_RS14015	COG3706	GGDEF domain
I6I39_RS14020	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6I39_RS14025	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I6I39_RS14030	COG0321	lipoyl(octanoyl) transferase activity
I6I39_RS14035	COG2921	Belongs to the UPF0250 family
I6I39_RS14040	COG1686	Belongs to the peptidase S11 family
I6I39_RS14045	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6I39_RS14050	COG0772	Belongs to the SEDS family
I6I39_RS14055	COG0768	penicillin binding
I6I39_RS14065	COG0799	negative regulation of ribosome biogenesis
I6I39_RS14070	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I6I39_RS14075	COG1466	dna polymerase III delta subunit
I6I39_RS14080	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
I6I39_RS14085	COG0495	leucyl-tRNA aminoacylation
I6I39_RS14090	COG2888	peptidyl-tyrosine sulfation
I6I39_RS14095	COG1126	abc transporter atp-binding protein
I6I39_RS14100	COG0765	amino acid transport
I6I39_RS14105	COG0765	amino acid transport
I6I39_RS14120	COG0815	Transfers the fatty acyl group on membrane lipoproteins
I6I39_RS14125	COG4535	Mg2 and Co2 transporter CorC
I6I39_RS14130	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I6I39_RS14135	COG1702	phosphate starvation-inducible protein PhoH
I6I39_RS14140	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6I39_RS14145	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6I39_RS14180	COG0367	asparagine synthase
I6I39_RS14185	COG0647	UMP catabolic process
I6I39_RS14190	COG1846	Transcriptional regulator
I6I39_RS14190	COG1940	carbohydrate kinase activity
I6I39_RS14195	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6I39_RS14200	COG0363	glucosamine-6-phosphate deaminase activity
I6I39_RS14205	COG1263	PTS System
I6I39_RS14205	COG2190	(PTS) system
I6I39_RS14205	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I39_RS14210	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6I39_RS14230	COG0735	belongs to the Fur family
I6I39_RS14240	COG0840	transmembrane signaling receptor activity
I6I39_RS14250	COG0596	Alpha beta hydrolase
I6I39_RS14255	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
I6I39_RS14260	COG0033	Phosphoglucomutase
I6I39_RS14275	COG0745	RESPONSE REGULATOR receiver
I6I39_RS14280	COG2205	protein histidine kinase activity
I6I39_RS14285	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
I6I39_RS14290	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
I6I39_RS14295	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
I6I39_RS14315	COG2994	toxin metabolic process
I6I39_RS14325	COG3272	Protein of unknown function (DUF1722)
I6I39_RS14335	COG5212	phosphodiesterase
I6I39_RS14340	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6I39_RS14350	COG1984	allophanate hydrolase subunit 2
I6I39_RS14355	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
I6I39_RS14370	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
I6I39_RS14385	COG2009	succinate dehydrogenase
I6I39_RS14390	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I6I39_RS14395	COG1053	succinate dehydrogenase
I6I39_RS14405	COG0567	Dehydrogenase, E1 component
I6I39_RS14410	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6I39_RS14415	COG0045	succinate-CoA ligase (ADP-forming) activity
I6I39_RS14420	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6I39_RS14425	COG0737	Belongs to the 5'-nucleotidase family
I6I39_RS14430	COG1271	oxidase subunit
I6I39_RS14435	COG1294	oxidase, subunit
I6I39_RS14440	COG4890	Cyd operon protein YbgT
I6I39_RS14445	COG3790	cyd operon protein YbgE
I6I39_RS14450	COG0824	Thioesterase
I6I39_RS14455	COG0811	peptide transport
I6I39_RS14460	COG0848	biopolymer transport protein
I6I39_RS14465	COG3064	Membrane
I6I39_RS14465	COG3064	Membrane
I6I39_RS14470	COG0823	Involved in the tonB-independent uptake of proteins
I6I39_RS14475	COG2885	chlorophyll binding
I6I39_RS14480	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
I6I39_RS14515	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I6I39_RS14525	COG1230	cation diffusion facilitator family transporter
I6I39_RS14530	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6I39_RS14535	COG0588	phosphoglycerate mutase activity
I6I39_RS14560	COG2017	converts alpha-aldose to the beta-anomer
I6I39_RS14565	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I6I39_RS14570	COG1085	galactose-1-phosphate uridylyltransferase
I6I39_RS14575	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6I39_RS14585	COG1119	ATPase activity
I6I39_RS14590	COG3585	molybdate ion transport
I6I39_RS14590	COG2005	Transcriptional regulator
I6I39_RS14600	COG0725	ABC transporter, periplasmic molybdate-binding protein
I6I39_RS14605	COG4149	molybdate abc transporter
I6I39_RS14615	COG0561	phosphatase activity
I6I39_RS14620	COG2706	6-phosphogluconolactonase activity
I6I39_RS14630	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I6I39_RS14635	COG0156	8-amino-7-oxononanoate synthase activity
I6I39_RS14640	COG2226	methyltransferase
I6I39_RS14655	COG0556	nucleotide-excision repair
I6I39_RS14660	COG4628	conserved protein (DUF2132)
I6I39_RS14665	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I6I39_RS14670	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I6I39_RS14675	COG0315	cyclic pyranopterin monophosphate synthase activity
I6I39_RS14680	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
I6I39_RS14685	COG0314	molybdopterin synthase activity
I6I39_RS14690	COG0670	Belongs to the BI1 family
I6I39_RS14695	COG0842	Transport permease protein
I6I39_RS14700	COG0842	Transport permease protein
I6I39_RS14705	COG1131	(ABC) transporter
I6I39_RS14710	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I39_RS14715	COG1309	transcriptional regulator
I6I39_RS14720	COG0513	Belongs to the DEAD box helicase family
I6I39_RS14725	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6I39_RS14735	COG2239	Acts as a magnesium transporter
I6I39_RS14745	COG1686	Belongs to the peptidase S11 family
I6I39_RS14750	COG0277	FAD linked oxidase domain protein
I6I39_RS14770	COG2261	transglycosylase associated protein
I6I39_RS14780	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
I6I39_RS14795	COG4807	Protein conserved in bacteria
I6I39_RS14815	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
I6I39_RS14825	COG2897	thiosulfate sulfurtransferase activity
I6I39_RS14840	COG1732	Glycine betaine
I6I39_RS14845	COG1174	glycine betaine transport
I6I39_RS14850	COG1125	glycine betaine transport
I6I39_RS14855	COG1174	glycine betaine transport
I6I39_RS14865	COG1028	Short-chain dehydrogenase reductase Sdr
I6I39_RS14880	COG0697	spore germination
I6I39_RS14900	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6I39_RS14905	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6I39_RS14925	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
I6I39_RS14935	COG1126	abc transporter atp-binding protein
I6I39_RS14940	COG0765	amino acid transport
I6I39_RS14945	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I39_RS14950	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I6I39_RS14955	COG0783	Belongs to the Dps family
I6I39_RS14960	COG4106	trans-aconitate 2-methyltransferase activity
I6I39_RS14975	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
I6I39_RS14990	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
I6I39_RS15010	COG0488	(ABC) transporter
I6I39_RS15020	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6I39_RS15025	COG0303	'Molybdopterin
I6I39_RS15040	COG0577	efflux transmembrane transporter activity
I6I39_RS15040	COG1136	(ABC) transporter
I6I39_RS15070	COG0583	DNA-binding transcription factor activity
I6I39_RS15075	COG0477	Major facilitator Superfamily
I6I39_RS15080	COG0302	gtp cyclohydrolase
I6I39_RS15085	COG2311	Membrane
I6I39_RS15110	COG3604	Transcriptional regulator
I6I39_RS15115	COG3383	formate dehydrogenase (NAD+) activity
I6I39_RS15120	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6I39_RS15125	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I6I39_RS15135	COG3260	NADH ubiquinone oxidoreductase 20
I6I39_RS15140	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6I39_RS15145	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
I6I39_RS15145	COG3261	NADH dehydrogenase
I6I39_RS15150	COG0651	ATP synthesis coupled electron transport
I6I39_RS15155	COG4237	Hydrogenase 4 membrane
I6I39_RS15160	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6I39_RS15165	COG0650	Formate hydrogenlyase subunit 4
I6I39_RS15170	COG0651	ATP synthesis coupled electron transport
I6I39_RS15175	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6I39_RS15180	COG0375	protein maturation
I6I39_RS15185	COG0298	carbon dioxide binding
I6I39_RS15190	COG2949	membrane
I6I39_RS15195	COG0281	malic enzyme
I6I39_RS15210	COG1346	cytolysis
I6I39_RS15215	COG1380	Effector of murein hydrolase LrgA
I6I39_RS15220	COG2814	Major facilitator Superfamily
I6I39_RS15240	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6I39_RS15240	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6I39_RS15245	COG0489	protein tyrosine kinase activity
I6I39_RS15250	COG0572	uridine kinase
I6I39_RS15260	COG2982	Protein involved in outer membrane biogenesis
I6I39_RS15265	COG3069	C4-dicarboxylate transmembrane transporter activity
I6I39_RS15270	COG1253	flavin adenine dinucleotide binding
I6I39_RS15315	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6I39_RS15345	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6I39_RS15350	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6I39_RS15355	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I6I39_RS15360	COG0140	phosphoribosyl-ATP diphosphatase activity
I6I39_RS15360	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I6I39_RS15365	COG0107	imidazoleglycerol-phosphate synthase activity
I6I39_RS15370	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
I6I39_RS15380	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I6I39_RS15380	COG0131	Imidazoleglycerol-phosphate dehydratase
I6I39_RS15385	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6I39_RS15395	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I6I39_RS15405	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6I39_RS15410	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6I39_RS15425	COG0371	Dehydrogenase
I6I39_RS15430	COG0531	amino acid
I6I39_RS15435	COG2925	Exonuclease
I6I39_RS15440	COG1022	Amp-dependent synthetase and ligase
I6I39_RS15440	COG3320	Male sterility
I6I39_RS15445	COG1289	transmembrane transporter activity
I6I39_RS15450	COG2926	Belongs to the UPF0265 family
I6I39_RS15460	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6I39_RS15465	COG1129	ABC transporter
I6I39_RS15480	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6I39_RS15490	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6I39_RS15510	COG4656	Part of a membrane complex involved in electron transport
I6I39_RS15520	COG1012	belongs to the aldehyde dehydrogenase family
I6I39_RS15530	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
I6I39_RS15605	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
I6I39_RS15615	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
I6I39_RS15680	COG1492	cobalamin metabolic process
I6I39_RS15700	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
I6I39_RS15765	COG3121	Chaperone
I6I39_RS15770	COG3188	usher protein
I6I39_RS15845	COG0137	argininosuccinate synthase activity
I6I39_RS15850	COG0534	Mate efflux family protein
I6I39_RS15860	COG0352	thiamine-phosphate diphosphorylase activity
I6I39_RS15865	COG0561	phosphatase activity
I6I39_RS15870	COG1349	DNA-binding transcription factor activity
I6I39_RS15880	COG0835	chemotaxis
I6I39_RS15880	COG0784	Response regulator, receiver
I6I39_RS15890	COG4221	oxidoreductase activity
I6I39_RS15915	COG3842	ATPase activity
I6I39_RS15925	COG1840	ABC-type Fe3 transport system, periplasmic component
I6I39_RS15930	COG2271	Major facilitator Superfamily
I6I39_RS15945	COG4565	transcriptional regulatory protein
I6I39_RS15950	COG3290	protein histidine kinase activity
I6I39_RS15955	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
I6I39_RS15960	COG3052	prosthetic group binding
I6I39_RS15965	COG2301	Belongs to the HpcH HpaI aldolase family
I6I39_RS15970	COG3051	citrate lyase alpha subunit
I6I39_RS15975	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
I6I39_RS15975	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
I6I39_RS15985	COG0471	metal ion transport
I6I39_RS16000	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I6I39_RS16015	COG2814	Major facilitator Superfamily
I6I39_RS16020	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I39_RS16020	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I39_RS16025	COG3122	Protein conserved in bacteria
I6I39_RS16045	COG3121	Chaperone
I6I39_RS16070	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I39_RS16070	COG2205	protein histidine kinase activity
I6I39_RS16135	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
I6I39_RS16140	COG0583	DNA-binding transcription factor activity
I6I39_RS16145	COG0582	viral genome integration into host DNA
I6I39_RS16155	COG3228	Belongs to the MtfA family
I6I39_RS16165	COG1070	Carbohydrate kinase
I6I39_RS16170	COG1070	Carbohydrate kinase
I6I39_RS16195	COG3121	Chaperone
I6I39_RS16215	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
I6I39_RS16220	COG2943	transferase activity, transferring hexosyl groups
I6I39_RS16240	COG2259	Doxx family
I6I39_RS16250	COG1560	Kdo2-lipid A biosynthetic process
I6I39_RS16285	COG1054	Belongs to the UPF0176 family
I6I39_RS16290	COG0628	permease
I6I39_RS16320	COG0418	dihydroorotase activity
I6I39_RS16325	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
I6I39_RS16330	COG1530	ribonuclease E activity
I6I39_RS16330	COG1530	ribonuclease E activity
I6I39_RS16335	COG0564	pseudouridine synthase activity
I6I39_RS16340	COG0424	maF-like protein
I6I39_RS16345	COG1399	metal-binding, possibly nucleic acid-binding protein
I6I39_RS16350	COG0333	Belongs to the bacterial ribosomal protein bL32 family
I6I39_RS16355	COG0416	fatty acid biosynthetic process
I6I39_RS16360	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6I39_RS16365	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I6I39_RS16370	COG1028	Short-chain dehydrogenase reductase Sdr
I6I39_RS16380	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6I39_RS16385	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6I39_RS16390	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6I39_RS16395	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I6I39_RS16400	COG0470	DNA polymerase III
I6I39_RS16405	COG0084	hydrolase, TatD family'
I6I39_RS16410	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I39_RS16410	COG1263	PTS System
I6I39_RS16430	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6I39_RS16435	COG0537	adenosine 5'-monophosphoramidase activity
I6I39_RS16440	COG5633	Lipoprotein
I6I39_RS16445	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
I6I39_RS16455	COG1472	Belongs to the glycosyl hydrolase 3 family
I6I39_RS16460	COG3150	esterase
I6I39_RS16465	COG1252	NADH dehydrogenase
I6I39_RS16470	COG3134	Outer membrane lipoprotein
I6I39_RS16475	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6I39_RS16480	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6I39_RS16490	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6I39_RS16495	COG1940	carbohydrate kinase activity
I6I39_RS16510	COG2850	peptidyl-arginine hydroxylation
I6I39_RS16520	COG0745	RESPONSE REGULATOR receiver
I6I39_RS16530	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6I39_RS16535	COG2915	High frequency lysogenization protein hflD homolog
I6I39_RS16540	COG0482	sulfurtransferase activity
I6I39_RS16550	COG1187	pseudouridine synthase activity
I6I39_RS16555	COG0538	isocitrate dehydrogenase activity
I6I39_RS16585	COG0538	isocitrate dehydrogenase activity
I6I39_RS16625	COG0840	transmembrane signaling receptor activity
I6I39_RS16645	COG2873	o-acetylhomoserine
I6I39_RS16650	COG0702	epimerase
I6I39_RS16655	COG1733	regulation of RNA biosynthetic process
I6I39_RS16690	COG3755	Protein conserved in bacteria
I6I39_RS16705	COG4251	negative regulation of phosphorylation
I6I39_RS16705	COG5001	Diguanylate cyclase
I6I39_RS16705	COG3706	GGDEF domain
I6I39_RS16705	COG2203	Gaf domain
I6I39_RS16725	COG1132	(ABC) transporter
I6I39_RS16745	COG2207	Transcriptional regulator
I6I39_RS16750	COG3328	transposase activity
I6I39_RS16785	COG1113	amino acid transport
I6I39_RS16805	COG1496	oxidoreductase activity
I6I39_RS16825	COG4811	Protein of unknown function (DUF986)
I6I39_RS16830	COG3716	PTS system mannose fructose sorbose family IID component
I6I39_RS16835	COG3715	PTS system
I6I39_RS16840	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I39_RS16840	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I39_RS16845	COG1253	flavin adenine dinucleotide binding
I6I39_RS16855	COG1760	l-serine dehydratase
I6I39_RS16860	COG0494	nUDIX hydrolase
I6I39_RS16870	COG3140	Belongs to the UPF0181 family
I6I39_RS16875	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
I6I39_RS16880	COG0513	Belongs to the DEAD box helicase family
I6I39_RS16885	COG3141	response to X-ray
I6I39_RS16890	COG3097	Belongs to the UPF0267 family
I6I39_RS16900	COG1770	oligopeptidase
I6I39_RS16905	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6I39_RS16920	COG1528	Iron-storage protein
I6I39_RS16925	COG2372	response to copper ion
I6I39_RS16930	COG1276	copper resistance
I6I39_RS16940	COG4974	Belongs to the 'phage' integrase family
I6I39_RS16990	COG3328	transposase activity
I6I39_RS16995	COG0500	methyltransferase
I6I39_RS17005	COG3328	transposase activity
I6I39_RS17010	COG0561	phosphatase activity
I6I39_RS17015	COG2223	nitrite transmembrane transporter activity
I6I39_RS17045	COG0672	)-iron permease
I6I39_RS17060	COG0577	efflux transmembrane transporter activity
I6I39_RS17060	COG1136	(ABC) transporter
I6I39_RS17070	COG0577	efflux transmembrane transporter activity
I6I39_RS17070	COG1136	(ABC) transporter
I6I39_RS17095	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6I39_RS17100	COG4114	ferric iron reductase
I6I39_RS17105	COG0006	proline dipeptidase activity
I6I39_RS17115	COG0726	polysaccharide deacetylase
I6I39_RS17115	COG1649	PFAM Uncharacterised BCR, COG1649
I6I39_RS17120	COG1215	transferase activity, transferring glycosyl groups
I6I39_RS17125	COG3658	cytochrome
I6I39_RS17135	COG1702	phosphate starvation-inducible protein PhoH
I6I39_RS17145	COG0018	arginyl-trna synthetase
I6I39_RS17150	COG3102	Protein conserved in bacteria
I6I39_RS17155	COG3142	Participates in the control of copper homeostasis
I6I39_RS17175	COG0668	transmembrane transport
I6I39_RS17180	COG0625	glutathione transferase activity
I6I39_RS17205	COG5001	Diguanylate cyclase
I6I39_RS17240	COG2814	Major facilitator Superfamily
I6I39_RS17250	COG3008	intermembrane lipid transfer
I6I39_RS17255	COG2995	paraquat-inducible protein a
I6I39_RS17260	COG1956	GAF domain-containing protein
I6I39_RS17270	COG0793	Belongs to the peptidase S41A family
I6I39_RS17275	COG0501	Belongs to the peptidase M48B family
I6I39_RS17285	COG2814	Major facilitator Superfamily
I6I39_RS17290	COG0823	Involved in the tonB-independent uptake of proteins
I6I39_RS17300	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6I39_RS17310	COG1823	symporter activity
I6I39_RS17315	COG1988	membrane-bound metal-dependent
I6I39_RS17320	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
I6I39_RS17325	COG1653	transport
I6I39_RS17330	COG3842	ATPase activity
I6I39_RS17335	COG0395	ABC-type sugar transport system, permease component
I6I39_RS17340	COG1175	transmembrane transport
I6I39_RS17350	COG1028	Short-chain dehydrogenase reductase Sdr
I6I39_RS17355	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
I6I39_RS17360	COG1917	Cupin 2, conserved barrel domain protein
I6I39_RS17365	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6I39_RS17375	COG0583	DNA-binding transcription factor activity
I6I39_RS17380	COG0427	acetyl-CoA hydrolase
I6I39_RS17385	COG1024	Enoyl-CoA hydratase
I6I39_RS17390	COG1703	isobutyryl-CoA mutase activity
I6I39_RS17395	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I6I39_RS17395	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I6I39_RS17400	COG3001	Fructosamine kinase
I6I39_RS17405	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6I39_RS17410	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6I39_RS17415	COG1121	(ABC) transporter
I6I39_RS17420	COG0803	Belongs to the bacterial solute-binding protein 9 family
I6I39_RS17450	COG1811	Na channel or pump
I6I39_RS17455	COG4249	Peptidase C14 caspase catalytic subunit p20
I6I39_RS17460	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I6I39_RS17465	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I6I39_RS17470	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I6I39_RS17475	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I6I39_RS17485	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I6I39_RS17495	COG0776	regulation of translation
I6I39_RS17500	COG2314	TM2 domain
I6I39_RS17510	COG4139	cobalamin transport
I6I39_RS17515	COG0386	Belongs to the glutathione peroxidase family
I6I39_RS17520	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
I6I39_RS17525	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6I39_RS17530	COG0463	Glycosyl transferase, family 2
I6I39_RS17535	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I6I39_RS17535	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6I39_RS17540	COG0726	polysaccharide deacetylase
I6I39_RS17545	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I6I39_RS17550	COG2076	Multidrug Resistance protein
I6I39_RS17555	COG2076	Multidrug Resistance protein
I6I39_RS17560	COG0791	NLP P60 protein
I6I39_RS17565	COG0095	Lipoate-protein ligase
I6I39_RS17575	COG4558	Periplasmic binding protein
I6I39_RS17580	COG3720	iron ion transport
I6I39_RS17600	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
I6I39_RS17605	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6I39_RS17605	COG0574	Belongs to the PEP-utilizing enzyme family
I6I39_RS17615	COG0628	permease
I6I39_RS17620	COG0247	lactate metabolic process
I6I39_RS17620	COG0277	FAD linked oxidase domain protein
I6I39_RS17625	COG2050	protein possibly involved in aromatic compounds catabolism
I6I39_RS17630	COG0316	Belongs to the HesB IscA family
I6I39_RS17635	COG0719	Fe-S assembly protein
I6I39_RS17640	COG0396	ATPase activity
I6I39_RS17645	COG0719	Fe-S assembly protein
I6I39_RS17655	COG2166	iron-sulfur cluster assembly
I6I39_RS17660	COG1376	ErfK ybiS ycfS ynhG family protein
I6I39_RS17660	COG1388	LysM domain
I6I39_RS17685	COG0534	Mate efflux family protein
I6I39_RS17690	COG0307	riboflavin synthase, alpha
I6I39_RS17695	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6I39_RS17700	COG2814	Major facilitator Superfamily
I6I39_RS17705	COG0583	DNA-binding transcription factor activity
I6I39_RS17710	COG1609	Transcriptional regulator
I6I39_RS17725	COG0791	NLP P60 protein
I6I39_RS17730	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I6I39_RS17740	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6I39_RS17750	COG0346	lactoylglutathione lyase activity
I6I39_RS17755	COG1902	pentaerythritol trinitrate reductase activity
I6I39_RS17760	COG1309	transcriptional regulator
I6I39_RS17765	COG2194	sulfuric ester hydrolase activity
I6I39_RS17770	COG3313	Fe-S protein
I6I39_RS17775	COG4989	oxidoreductase activity
I6I39_RS17780	COG1289	transmembrane transporter activity
I6I39_RS17785	COG1566	PFAM secretion protein HlyD family protein
I6I39_RS17795	COG1846	Transcriptional regulator
I6I39_RS17800	COG3133	Outer membrane lipoprotein
I6I39_RS17805	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
I6I39_RS17810	COG3895	Periplasmic Protein
I6I39_RS17815	COG0259	pyridoxamine-phosphate oxidase activity
I6I39_RS17820	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I6I39_RS17830	COG0625	glutathione transferase activity
I6I39_RS17850	COG3104	oligopeptide transport
I6I39_RS17865	COG4172	Belongs to the ABC transporter superfamily
I6I39_RS17875	COG4171	peptide transport system, permease
I6I39_RS17880	COG4168	peptide transport system, permease
I6I39_RS17885	COG4166	transmembrane transport
I6I39_RS17910	COG1349	DNA-binding transcription factor activity
I6I39_RS17915	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6I39_RS17920	COG2879	small protein
I6I39_RS17925	COG1966	Carbon starvation protein
I6I39_RS17935	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
I6I39_RS17940	COG0243	molybdopterin cofactor binding
I6I39_RS17960	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6I39_RS17970	COG4659	FMN binding
I6I39_RS17975	COG4658	electron transport chain
I6I39_RS17980	COG2207	Transcriptional regulator
I6I39_RS17980	COG3708	Transcriptional regulator
I6I39_RS17990	COG4656	Part of a membrane complex involved in electron transport
I6I39_RS18000	COG4657	Part of a membrane complex involved in electron transport
I6I39_RS18010	COG2759	Belongs to the formate--tetrahydrofolate ligase family
I6I39_RS18025	COG2274	protein secretion by the type I secretion system
I6I39_RS18030	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6I39_RS18035	COG2160	L-arabinose isomerase activity
I6I39_RS18045	COG1879	ABC-type sugar transport system periplasmic component
I6I39_RS18050	COG1129	ABC transporter
I6I39_RS18055	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6I39_RS18065	COG0673	inositol 2-dehydrogenase activity
I6I39_RS18070	COG0385	Bile acid
I6I39_RS18075	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I6I39_RS18080	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I6I39_RS18100	COG5339	Protein conserved in bacteria
I6I39_RS18110	COG0114	fumarate hydratase activity
I6I39_RS18140	COG2814	Major facilitator Superfamily
I6I39_RS18145	COG0583	DNA-binding transcription factor activity
I6I39_RS18150	COG1940	carbohydrate kinase activity
I6I39_RS18155	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
I6I39_RS18185	COG1742	UPF0060 membrane protein
I6I39_RS18190	COG4221	oxidoreductase activity
I6I39_RS18300	COG4128	Pfam Zonular occludens toxin
I6I39_RS18325	COG0625	glutathione transferase activity
I6I39_RS18350	COG1522	sequence-specific DNA binding
I6I39_RS18385	COG3177	Filamentation induced by cAMP protein fic
I6I39_RS18395	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6I39_RS18405	COG0483	inositol monophosphate 1-phosphatase activity
I6I39_RS18440	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6I39_RS18450	COG0028	Belongs to the TPP enzyme family
I6I39_RS18455	COG0440	acetolactate synthase activity
I6I39_RS18460	COG1011	Hydrolase
I6I39_RS18475	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6I39_RS18485	COG1028	Short-chain dehydrogenase reductase Sdr
I6I39_RS18490	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
I6I39_RS18505	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6I39_RS18510	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6I39_RS18515	COG0589	response to stress
I6I39_RS18520	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
I6I39_RS18525	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
I6I39_RS18535	COG0531	amino acid
I6I39_RS18545	COG0745	RESPONSE REGULATOR receiver
I6I39_RS18550	COG2205	protein histidine kinase activity
I6I39_RS18555	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
I6I39_RS18565	COG3591	Belongs to the peptidase S1B family
I6I39_RS18580	COG1643	Atp-dependent helicase
I6I39_RS18585	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I6I39_RS18590	COG3784	Protein of unknown function (DUF1318)
I6I39_RS18600	COG2911	Protein conserved in bacteria
I6I39_RS18605	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6I39_RS18610	COG3042	response to heat
I6I39_RS18615	COG1285	pathogenesis
I6I39_RS18625	COG1013	pyruvate-flavodoxin oxidoreductase activity
I6I39_RS18625	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6I39_RS18625	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I6I39_RS18625	COG0674	pyruvate-flavodoxin oxidoreductase activity
I6I39_RS18630	COG0823	Involved in the tonB-independent uptake of proteins
I6I39_RS18635	COG0037	tRNA processing
I6I39_RS18640	COG0598	Magnesium transport protein CorA
I6I39_RS18645	COG4166	transmembrane transport
I6I39_RS18650	COG2866	Carboxypeptidase
I6I39_RS18655	COG4948	Mandelate Racemase Muconate Lactonizing
I6I39_RS18660	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
I6I39_RS18670	COG5642	Protein of unknown function (DUF2384)
I6I39_RS18675	COG5654	RES domain protein
I6I39_RS18680	COG3768	UPF0283 membrane protein
I6I39_RS18685	COG3106	COG3106 Predicted ATPase
I6I39_RS18695	COG1983	PspC domain protein
I6I39_RS18705	COG1842	Phage shock protein A
I6I39_RS18710	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I6I39_RS18730	COG0023	Translation Initiation Factor
I6I39_RS18735	COG0284	orotidine-5'-phosphate decarboxylase activity
I6I39_RS18750	COG1396	sequence-specific DNA binding
I6I39_RS18760	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
I6I39_RS18765	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
I6I39_RS18770	COG0671	phosphoesterase, PA-phosphatase related
I6I39_RS18790	COG0583	DNA-binding transcription factor activity
I6I39_RS18805	COG0616	signal peptide processing
I6I39_RS18810	COG1028	Short-chain dehydrogenase reductase Sdr
I6I39_RS18815	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
I6I39_RS18825	COG1187	pseudouridine synthase activity
I6I39_RS18830	COG0009	L-threonylcarbamoyladenylate synthase
I6I39_RS18835	COG0613	PHP domain protein
I6I39_RS18850	COG0512	Glutamine amidotransferase of anthranilate synthase
I6I39_RS18860	COG0135	phosphoribosylanthranilate isomerase activity
I6I39_RS18860	COG0134	indole-3-glycerol-phosphate synthase activity
I6I39_RS18865	COG0133	tryptophan synthase activity
I6I39_RS18870	COG0159	tryptophan synthase activity
I6I39_RS18880	COG3047	cAMP biosynthetic process
I6I39_RS18885	COG0727	PFAM Uncharacterised protein family (UPF0153)
I6I39_RS18900	COG2917	probably involved in intracellular septation
I6I39_RS18905	COG1607	acyl-coa hydrolase
I6I39_RS18910	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
I6I39_RS18915	COG2350	Protein conserved in bacteria
I6I39_RS18940	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6I39_RS18945	COG3099	Belongs to the UPF0263 family
I6I39_RS18955	COG0444	Belongs to the ABC transporter superfamily
I6I39_RS18960	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I39_RS18980	COG2095	MarC family integral membrane protein
I6I39_RS18985	COG1012	belongs to the aldehyde dehydrogenase family
I6I39_RS18985	COG1454	alcohol dehydrogenase
I6I39_RS18995	COG2916	Histone family protein nucleoid-structuring protein H-NS
I6I39_RS19010	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6I39_RS19020	COG3012	SEC-C Motif Domain Protein
I6I39_RS19025	COG0788	formyltetrahydrofolate deformylase activity
I6I39_RS19040	COG0583	DNA-binding transcription factor activity
I6I39_RS19045	COG0708	Exodeoxyribonuclease III
I6I39_RS19050	COG0494	nUDIX hydrolase
I6I39_RS19060	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6I39_RS19070	COG0778	Nitroreductase
I6I39_RS19075	COG0616	signal peptide processing
I6I39_RS19080	COG0252	asparaginase activity
I6I39_RS19085	COG1335	isochorismatase
I6I39_RS19095	COG3139	Protein of unknown function (DUF1315)
I6I39_RS19100	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6I39_RS19115	COG3713	MltA-interacting MipA family protein
I6I39_RS19120	COG2766	serine protein kinase
I6I39_RS19125	COG2718	Belongs to the UPF0229 family
I6I39_RS19140	COG0583	DNA-binding transcription factor activity
I6I39_RS19150	COG2199	diguanylate cyclase activity
I6I39_RS19150	COG2200	EAL domain
I6I39_RS19150	COG2202	Pas domain
I6I39_RS19155	COG2814	Major facilitator Superfamily
I6I39_RS19160	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6I39_RS19165	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6I39_RS19170	COG2719	SpoVR family
I6I39_RS19175	COG2186	Transcriptional regulator
I6I39_RS19180	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I6I39_RS19185	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
I6I39_RS19205	COG2983	Belongs to the UPF0260 family
I6I39_RS19210	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6I39_RS19215	COG2951	lytic endotransglycosylase activity
I6I39_RS19220	COG3100	YcgL domain-containing protein
I6I39_RS19230	COG0850	regulation of cytokinetic process
I6I39_RS19235	COG2894	cell division
I6I39_RS19240	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
I6I39_RS19245	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
I6I39_RS19250	COG0318	PFAM AMP-dependent synthetase and ligase
I6I39_RS19255	COG3065	identical protein binding
I6I39_RS19265	COG1199	ATP-dependent helicase activity
I6I39_RS19270	COG0251	oxidation-reduction process
I6I39_RS19275	COG2076	Multidrug Resistance protein
I6I39_RS19280	COG2076	Multidrug Resistance protein
I6I39_RS19285	COG0800	Aldolase
I6I39_RS19290	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I6I39_RS19295	COG1737	Transcriptional regulator
I6I39_RS19300	COG0469	pyruvate kinase activity
I6I39_RS19310	COG1560	Kdo2-lipid A biosynthetic process
I6I39_RS19315	COG0739	heme binding
I6I39_RS19320	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
I6I39_RS19325	COG1121	(ABC) transporter
I6I39_RS19330	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6I39_RS19335	COG3104	oligopeptide transport
I6I39_RS19340	COG2255	four-way junction helicase activity
I6I39_RS19345	COG0632	four-way junction helicase activity
I6I39_RS19350	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
I6I39_RS19355	COG0217	transcriptional regulatory protein
I6I39_RS19360	COG0494	nUDIX hydrolase
I6I39_RS19365	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I6I39_RS19375	COG1335	isochorismatase
I6I39_RS19380	COG1801	Protein of unknown function DUF72
I6I39_RS19385	COG3788	relative of glutathione S-transferase, MAPEG superfamily
I6I39_RS19390	COG2226	methyltransferase
I6I39_RS19395	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6I39_RS19410	COG0786	glutamate:sodium symporter activity
I6I39_RS19415	COG1187	pseudouridine synthase activity
I6I39_RS19435	COG1349	DNA-binding transcription factor activity
I6I39_RS19445	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I39_RS19455	COG3716	PTS system mannose fructose sorbose family IID component
I6I39_RS19460	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I39_RS19465	COG2222	sugar isomerase
I6I39_RS19475	COG4942	peptidase
I6I39_RS19500	COG3443	Belongs to the bacterial solute-binding protein 9 family
I6I39_RS19510	COG0402	S-adenosylhomocysteine deaminase activity
I6I39_RS19520	COG1228	amidohydrolase
I6I39_RS19545	COG2988	succinylglutamate desuccinylase activity
I6I39_RS19550	COG3724	N-succinylarginine dihydrolase activity
I6I39_RS19560	COG3138	arginine N-succinyltransferase
I6I39_RS19565	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6I39_RS19570	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I39_RS19575	COG1271	oxidase subunit
I6I39_RS19580	COG1294	oxidase, subunit
I6I39_RS19590	COG3850	Histidine kinase
I6I39_RS19595	COG0583	DNA-binding transcription factor activity
I6I39_RS19605	COG2814	Major facilitator Superfamily
I6I39_RS19615	COG0387	Pfam Sodium calcium exchanger
I6I39_RS19620	COG0728	peptidoglycan biosynthetic process
I6I39_RS19625	COG0673	inositol 2-dehydrogenase activity
I6I39_RS19635	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6I39_RS19650	COG0477	Major facilitator Superfamily
I6I39_RS19660	COG3381	protein complex oligomerization
I6I39_RS19665	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
I6I39_RS19670	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6I39_RS19690	COG3706	GGDEF domain
I6I39_RS19695	COG0659	secondary active sulfate transmembrane transporter activity
I6I39_RS19700	COG2877	3-deoxy-8-phosphooctulonate synthase activity
I6I39_RS19715	COG2890	protein-(glutamine-N5) methyltransferase activity
I6I39_RS19720	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I6I39_RS19725	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
I6I39_RS19730	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
I6I39_RS19740	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6I39_RS19750	COG0193	aminoacyl-tRNA hydrolase activity
I6I39_RS19760	COG0012	GTP binding
I6I39_RS19775	COG2979	Protein of unknown function (DUF533)
I6I39_RS19780	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
I6I39_RS19785	COG3772	lysozyme
I6I39_RS19915	COG3041	Addiction module toxin RelE StbE family
I6I39_RS19920	COG3077	Addiction module antitoxin, RelB DinJ family
I6I39_RS19975	COG4974	Belongs to the 'phage' integrase family
I6I39_RS20040	COG4695	Portal protein
I6I39_RS20190	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6I39_RS20195	COG0322	excinuclease ABC activity
I6I39_RS20200	COG2197	response regulator
I6I39_RS20210	COG3136	membrane protein required for alginate biosynthesis
I6I39_RS20220	COG0366	Alpha amylase catalytic
I6I39_RS20235	COG2226	methyltransferase
I6I39_RS20255	COG1113	amino acid transport
I6I39_RS20260	COG1309	transcriptional regulator
I6I39_RS20270	COG1335	isochorismatase
I6I39_RS20275	COG0251	oxidation-reduction process
I6I39_RS20280	COG2267	carboxylic ester hydrolase activity
I6I39_RS20285	COG0778	Nitroreductase
I6I39_RS20290	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6I39_RS20300	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
I6I39_RS20310	COG0655	NAD(P)H dehydrogenase (quinone) activity
I6I39_RS20320	COG2822	iron ion transport
I6I39_RS20325	COG0672	)-iron permease
I6I39_RS20330	COG3157	Type VI secretion system effector, Hcp
I6I39_RS20345	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6I39_RS20345	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6I39_RS20345	COG0506	proline dehydrogenase activity
I6I39_RS20360	COG1126	abc transporter atp-binding protein
I6I39_RS20365	COG0765	amino acid transport
I6I39_RS20370	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I39_RS20375	COG2515	1-aminocyclopropane-1-carboxylate deaminase
I6I39_RS20385	COG1191	sigma factor activity
I6I39_RS20430	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
I6I39_RS20435	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
I6I39_RS20455	COG0582	viral genome integration into host DNA
I6I39_RS20460	COG1677	Flagellar hook-basal body complex protein FliE
I6I39_RS20475	COG1317	bacterial-type flagellum organization
I6I39_RS20495	COG1580	Controls the rotational direction of flagella during chemotaxis