locus-tag	class	description
LI89_RS00005	COG0716	FMN binding
LI89_RS00010	COG1522	sequence-specific DNA binding
LI89_RS00015	COG2502	aspartate--ammonia ligase
LI89_RS00025	COG2425	protein containing a von Willebrand factor type A (vWA) domain
LI89_RS00030	COG0714	Associated with various cellular activities
LI89_RS00035	COG3158	transport of potassium into the cell
LI89_RS00040	COG1869	D-ribose catabolic process
LI89_RS00050	COG1172	Belongs to the binding-protein-dependent transport system permease family
LI89_RS00055	COG1879	ABC-type sugar transport system periplasmic component
LI89_RS00060	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LI89_RS00065	COG1609	Transcriptional regulator
LI89_RS00070	COG0477	Major facilitator Superfamily
LI89_RS00075	COG2186	Transcriptional regulator
LI89_RS00100	COG1763	Mo-molybdopterin cofactor biosynthetic process
LI89_RS00110	COG3084	Protein conserved in bacteria
LI89_RS00115	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
LI89_RS00120	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LI89_RS00125	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LI89_RS00125	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LI89_RS00130	COG0218	Necessary for normal cell division and for the maintenance of normal septation
LI89_RS00135	COG3078	GTPase activator activity
LI89_RS00140	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LI89_RS00150	COG3852	Histidine kinase
LI89_RS00165	COG1011	Hydrolase
LI89_RS00170	COG1295	ribonuclease BN
LI89_RS00175	COG1490	D-aminoacyl-tRNA deacylase activity
LI89_RS00180	COG0456	acetyltransferase
LI89_RS00185	COG3423	Transcriptional regulator
LI89_RS00205	COG2982	Protein involved in outer membrane biogenesis
LI89_RS00210	COG2233	PERMEase
LI89_RS00215	COG0786	glutamate:sodium symporter activity
LI89_RS00220	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LI89_RS00225	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LI89_RS00230	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LI89_RS00235	COG1758	RNA polymerase activity
LI89_RS00245	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LI89_RS00250	COG2860	membrane
LI89_RS00260	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LI89_RS00265	COG1024	Enoyl-CoA hydratase
LI89_RS00270	COG5001	Diguanylate cyclase
LI89_RS00285	COG1561	YicC-like family, N-terminal region
LI89_RS00290	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
LI89_RS00295	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
LI89_RS00300	COG1309	transcriptional regulator
LI89_RS00305	COG0756	dUTP diphosphatase activity
LI89_RS00310	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
LI89_RS00315	COG2003	Belongs to the UPF0758 family
LI89_RS00320	COG0227	Belongs to the bacterial ribosomal protein bL28 family
LI89_RS00325	COG0267	Belongs to the bacterial ribosomal protein bL33 family
LI89_RS00330	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LI89_RS00335	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
LI89_RS00345	COG1519	Transferase
LI89_RS00350	COG0859	PFAM glycosyl transferase family 9
LI89_RS00355	COG0859	PFAM glycosyl transferase family 9
LI89_RS00360	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LI89_RS00365	COG0156	8-amino-7-oxononanoate synthase activity
LI89_RS00370	COG1063	alcohol dehydrogenase
LI89_RS00375	COG2861	carbohydrate metabolic process
LI89_RS00380	COG4942	peptidase
LI89_RS00385	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
LI89_RS00390	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LI89_RS00395	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
LI89_RS00400	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
LI89_RS00405	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
LI89_RS00410	COG1045	serine acetyltransferase
LI89_RS00415	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
LI89_RS00420	COG2169	Transcriptional regulator
LI89_RS00420	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LI89_RS00425	COG2205	protein histidine kinase activity
LI89_RS00430	COG0745	RESPONSE REGULATOR receiver
LI89_RS00435	COG3678	ATP-independent chaperone mediated protein folding
LI89_RS00440	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
LI89_RS00450	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
LI89_RS00460	COG0149	triose-phosphate isomerase activity
LI89_RS00470	COG3152	Membrane
LI89_RS00480	COG2814	Major facilitator Superfamily
LI89_RS00485	COG1494	fructose-1,6-bisphosphatase
LI89_RS00490	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LI89_RS00495	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LI89_RS00505	COG3074	FtsZ-dependent cytokinesis
LI89_RS00510	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
LI89_RS00515	COG1575	Belongs to the MenA family. Type 1 subfamily
LI89_RS00520	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
LI89_RS00525	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
LI89_RS00530	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
LI89_RS00535	COG1609	Transcriptional regulator
LI89_RS00540	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
LI89_RS00545	COG0254	rRNA binding
LI89_RS00550	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
LI89_RS00555	COG0626	cystathionine gamma-synthase activity
LI89_RS00560	COG0527	aspartate kinase activity
LI89_RS00560	COG0460	homoserine dehydrogenase
LI89_RS00570	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
LI89_RS00585	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LI89_RS00590	COG0165	Argininosuccinate lyase
LI89_RS00595	COG1629	transport
LI89_RS00635	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LI89_RS00640	COG0678	peroxiredoxin activity
LI89_RS00640	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
LI89_RS00650	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LI89_RS00655	COG1309	transcriptional regulator
LI89_RS00665	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LI89_RS00675	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
LI89_RS00705	COG5544	Lipoprotein
LI89_RS00710	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LI89_RS00730	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
LI89_RS00770	COG1879	ABC-type sugar transport system periplasmic component
LI89_RS00775	COG1129	ABC transporter
LI89_RS00780	COG1172	Belongs to the binding-protein-dependent transport system permease family
LI89_RS00785	COG1172	Belongs to the binding-protein-dependent transport system permease family
LI89_RS00790	COG0583	DNA-binding transcription factor activity
LI89_RS00795	COG3085	chromosome segregation
LI89_RS00810	COG3978	acetolactate synthase activity
LI89_RS00815	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LI89_RS00820	COG0129	dihydroxy-acid dehydratase activity
LI89_RS00825	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LI89_RS00835	COG0583	DNA-binding transcription factor activity
LI89_RS00840	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
LI89_RS00865	COG3121	Chaperone
LI89_RS00880	COG3121	Chaperone
LI89_RS00890	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LI89_RS00905	COG0248	Ppx GppA phosphatase
LI89_RS00915	COG3118	belongs to the thioredoxin family
LI89_RS00920	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
LI89_RS00925	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LI89_RS00930	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
LI89_RS00935	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
LI89_RS00940	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
LI89_RS00945	COG1088	dTDP-glucose 4,6-dehydratase activity
LI89_RS00950	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
LI89_RS00955	COG0456	acetyltransferase
LI89_RS00960	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LI89_RS00965	COG2244	polysaccharide biosynthetic process
LI89_RS00970	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LI89_RS01010	COG3071	HemY protein
LI89_RS01015	COG2959	enzyme of heme biosynthesis
LI89_RS01020	COG1587	Uroporphyrinogen-III synthase
LI89_RS01025	COG0181	hydroxymethylbilane synthase activity
LI89_RS01030	COG3072	Adenylate cyclase
LI89_RS01035	COG1965	Belongs to the frataxin family
LI89_RS01045	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
LI89_RS01050	COG3159	Protein conserved in bacteria
LI89_RS01055	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
LI89_RS01060	COG1011	Hydrolase
LI89_RS01065	COG0210	DNA helicase
LI89_RS01075	COG5441	Belongs to the UPF0261 family
LI89_RS01080	COG5564	TIM-barrel signal transduction protein
LI89_RS01095	COG2050	protein possibly involved in aromatic compounds catabolism
LI89_RS01100	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
LI89_RS01105	COG0514	ATP-dependent DNA helicase (RecQ)
LI89_RS01110	COG1280	lysine exporter protein (LysE YggA)
LI89_RS01115	COG1280	lysine exporter protein (LysE YggA)
LI89_RS01120	COG2267	carboxylic ester hydrolase activity
LI89_RS01125	COG0561	phosphatase activity
LI89_RS01130	COG0584	glycerophosphoryl diester phosphodiesterase
LI89_RS01135	COG2271	Major facilitator Superfamily
LI89_RS01140	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
LI89_RS01145	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
LI89_RS01150	COG0247	lactate metabolic process
LI89_RS01160	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
LI89_RS01165	COG0425	Belongs to the sulfur carrier protein TusA family
LI89_RS01170	COG2217	Heavy metal translocating P-type atpase
LI89_RS01175	COG3714	YhhN family
LI89_RS01190	COG3776	membrane
LI89_RS01195	COG0742	ribosomal rna small subunit methyltransferase
LI89_RS01200	COG0552	protein localization to endoplasmic reticulum
LI89_RS01205	COG2884	Cell division ATP-binding protein ftsE
LI89_RS01210	COG2177	Part of the ABC transporter FtsEX involved in
LI89_RS01225	COG0683	leucine binding
LI89_RS01235	COG4177	L-phenylalanine transmembrane transporter activity
LI89_RS01245	COG0410	ABC transporter
LI89_RS01280	COG1653	transport
LI89_RS01285	COG1175	transmembrane transport
LI89_RS01290	COG0395	ABC-type sugar transport system, permease component
LI89_RS01295	COG3842	ATPase activity
LI89_RS01300	COG0584	glycerophosphoryl diester phosphodiesterase
LI89_RS01305	COG0679	Auxin Efflux Carrier
LI89_RS01310	COG0697	spore germination
LI89_RS01315	COG0583	DNA-binding transcription factor activity
LI89_RS01320	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
LI89_RS01325	COG0412	Dienelactone hydrolase
LI89_RS01340	COG1966	Carbon starvation protein
LI89_RS01345	COG0586	Pfam SNARE associated Golgi protein
LI89_RS01350	COG1322	Protein conserved in bacteria
LI89_RS01355	COG2226	methyltransferase
LI89_RS01365	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
LI89_RS01370	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LI89_RS01375	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LI89_RS01380	COG0805	protein transport
LI89_RS01400	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
LI89_RS01410	COG0183	Belongs to the thiolase family
LI89_RS01415	COG1024	Enoyl-CoA hydratase
LI89_RS01415	COG1250	3-hydroxyacyl-CoA dehydrogenase
LI89_RS01420	COG0006	proline dipeptidase activity
LI89_RS01425	COG1739	Uncharacterized protein family UPF0029
LI89_RS01430	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LI89_RS01465	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
LI89_RS01465	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
LI89_RS01470	COG1072	(Pantothenic acid kinase))
LI89_RS01505	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LI89_RS01515	COG0250	Participates in transcription elongation, termination and antitermination
LI89_RS01520	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
LI89_RS01525	COG0081	regulation of translation
LI89_RS01530	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
LI89_RS01535	COG0222	ribosome binding
LI89_RS01540	COG0085	RNA polymerase activity
LI89_RS01545	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
LI89_RS01555	COG2022	thiamine diphosphate biosynthetic process
LI89_RS01560	COG2104	thiamine diphosphate biosynthetic process
LI89_RS01565	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
LI89_RS01580	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
LI89_RS01585	COG2816	NAD+ diphosphatase activity
LI89_RS01595	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
LI89_RS01600	COG1515	deoxyribonuclease V activity
LI89_RS01620	COG0151	Belongs to the GarS family
LI89_RS01625	COG0138	bifunctional purine biosynthesis protein purh
LI89_RS01675	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LI89_RS01680	COG3162	membrane
LI89_RS01685	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LI89_RS01690	COG1301	dicarboxylic acid transport
LI89_RS01695	COG2197	response regulator
LI89_RS01700	COG2205	protein histidine kinase activity
LI89_RS01700	COG0784	Response regulator, receiver
LI89_RS01855	COG2391	methyltransferase activity
LI89_RS01860	COG0425	Belongs to the sulfur carrier protein TusA family
LI89_RS01875	COG3712	iron ion homeostasis
LI89_RS01880	COG4771	TonB-dependent receptor
LI89_RS01885	COG4178	(ABC) transporter
LI89_RS01890	COG0612	Peptidase, M16
LI89_RS01895	COG1511	domain protein
LI89_RS01895	COG3264	Mechanosensitive ion channel
LI89_RS01900	COG4774	siderophore transport
LI89_RS01910	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LI89_RS01915	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
LI89_RS01920	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LI89_RS01925	COG4558	Periplasmic binding protein
LI89_RS01930	COG3720	iron ion transport
LI89_RS01945	COG0702	epimerase
LI89_RS01950	COG3721	Heme iron utilization protein
LI89_RS01965	COG0814	amino acid
LI89_RS01970	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
LI89_RS01975	COG1882	Formate acetyltransferase
LI89_RS01985	COG1309	transcriptional regulator
LI89_RS01990	COG1929	Belongs to the glycerate kinase type-1 family
LI89_RS01995	COG4232	protein-disulfide reductase activity
LI89_RS02005	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
LI89_RS02020	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
LI89_RS02045	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LI89_RS02065	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
LI89_RS02070	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
LI89_RS02075	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
LI89_RS02080	COG1053	succinate dehydrogenase
LI89_RS02085	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
LI89_RS02090	COG3264	Mechanosensitive ion channel
LI89_RS02090	COG1511	domain protein
LI89_RS02095	COG0688	phosphatidylethanolamine metabolic process
LI89_RS02100	COG1162	GTPase activity
LI89_RS02105	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
LI89_RS02125	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
LI89_RS02130	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
LI89_RS02130	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
LI89_RS02135	COG0802	atpase or kinase
LI89_RS02140	COG0860	N-Acetylmuramoyl-L-alanine amidase
LI89_RS02145	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
LI89_RS02150	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
LI89_RS02155	COG1923	regulation of RNA biosynthetic process
LI89_RS02160	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LI89_RS02165	COG0330	HflC and HflK could
LI89_RS02170	COG0330	HflC and HflK could
LI89_RS02175	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
LI89_RS02180	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
LI89_RS02185	COG1959	2 iron, 2 sulfur cluster binding
LI89_RS02190	COG0557	exoribonuclease II activity
LI89_RS02195	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LI89_RS02200	COG1960	acyl-CoA dehydrogenase activity
LI89_RS02205	COG3650	response to hydrogen peroxide
LI89_RS02210	COG1073	alpha beta
LI89_RS02220	COG0360	Binds together with S18 to 16S ribosomal RNA
LI89_RS02225	COG2965	DNA replication, synthesis of RNA primer
LI89_RS02230	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
LI89_RS02235	COG0359	binds to the 23S rRNA
LI89_RS02245	COG3061	Opacity-associated protein A
LI89_RS02250	COG0545	Peptidyl-prolyl cis-trans isomerase
LI89_RS02260	COG0737	Belongs to the 5'-nucleotidase family
LI89_RS02265	COG1218	3'(2'),5'-bisphosphate nucleotidase
LI89_RS02270	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
LI89_RS02280	COG1253	flavin adenine dinucleotide binding
LI89_RS02285	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LI89_RS02300	COG2105	PFAM AIG2 family protein
LI89_RS02305	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
LI89_RS02315	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
LI89_RS02320	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LI89_RS02330	COG1438	arginine binding
LI89_RS02335	COG0039	L-malate dehydrogenase activity
LI89_RS02340	COG3423	Transcriptional regulator
LI89_RS02350	COG0142	geranyltranstransferase activity
LI89_RS02355	COG0261	This protein binds to 23S rRNA in the presence of protein L20
LI89_RS02360	COG0211	Belongs to the bacterial ribosomal protein bL27 family
LI89_RS02365	COG0697	spore germination
LI89_RS02370	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
LI89_RS02375	COG0642	Histidine kinase
LI89_RS02380	COG0745	RESPONSE REGULATOR receiver
LI89_RS02385	COG2027	D-alanyl-D-alanine carboxypeptidase
LI89_RS02395	COG1534	Rna-binding protein
LI89_RS02400	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
LI89_RS02410	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
LI89_RS02415	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LI89_RS02420	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LI89_RS02435	COG0779	Required for maturation of 30S ribosomal subunits
LI89_RS02440	COG0195	Participates in both transcription termination and antitermination
LI89_RS02445	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
LI89_RS02450	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
LI89_RS02455	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
LI89_RS02460	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
LI89_RS02465	COG1185	polyribonucleotide nucleotidyltransferase activity
LI89_RS02475	COG0513	Belongs to the DEAD box helicase family
LI89_RS02485	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LI89_RS02490	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LI89_RS02495	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LI89_RS02505	COG0814	amino acid
LI89_RS02510	COG3681	Belongs to the UPF0597 family
LI89_RS02515	COG0826	peptidase U32
LI89_RS02520	COG0826	peptidase U32
LI89_RS02525	COG3154	lipid carrier protein
LI89_RS02530	COG3153	acetyltransferase
LI89_RS02535	COG2827	Endonuclease containing a URI domain
LI89_RS02540	COG0531	amino acid
LI89_RS02545	COG1982	Orn Lys Arg decarboxylase major
LI89_RS02560	COG1653	transport
LI89_RS02565	COG1175	transmembrane transport
LI89_RS02570	COG0395	ABC-type sugar transport system, permease component
LI89_RS02575	COG3842	ATPase activity
LI89_RS02585	COG3787	Belongs to the UPF0306 family
LI89_RS02595	COG0702	epimerase
LI89_RS02600	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
LI89_RS02605	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
LI89_RS02610	COG3454	Phosphonate metabolism
LI89_RS02615	COG4778	phosphonate C-P lyase system protein PhnL
LI89_RS02620	COG4107	phosphonate C-P lyase system protein PhnK
LI89_RS02625	COG3627	carbon phosphorus lyase activity
LI89_RS02630	COG3626	phosphonate metabolism
LI89_RS02635	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
LI89_RS02640	COG3624	Phosphonate C-P lyase system protein PhnG
LI89_RS02645	COG2188	Transcriptional regulator
LI89_RS02670	COG0583	DNA-binding transcription factor activity
LI89_RS02675	COG2249	NAD(P)H dehydrogenase (quinone) activity
LI89_RS02690	COG4608	Belongs to the ABC transporter superfamily
LI89_RS02695	COG0444	Belongs to the ABC transporter superfamily
LI89_RS02700	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LI89_RS02705	COG0601	transmembrane transport
LI89_RS02715	COG2731	YhcH YjgK YiaL family protein
LI89_RS02725	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
LI89_RS02740	COG2927	DNA polymerase III (CHI subunit)
LI89_RS02745	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LI89_RS02750	COG0795	lipopolysaccharide-transporting ATPase activity
LI89_RS02755	COG0795	lipopolysaccharide-transporting ATPase activity
LI89_RS02765	COG0582	viral genome integration into host DNA
LI89_RS02800	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LI89_RS02890	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
LI89_RS02895	COG1830	Aldolase
LI89_RS02900	COG1879	ABC-type sugar transport system periplasmic component
LI89_RS02905	COG1172	Belongs to the binding-protein-dependent transport system permease family
LI89_RS02910	COG1172	Belongs to the binding-protein-dependent transport system permease family
LI89_RS02915	COG1129	ABC transporter
LI89_RS02920	COG2390	Transcriptional regulator
LI89_RS02925	COG1070	Carbohydrate kinase
LI89_RS02930	COG0859	PFAM glycosyl transferase family 9
LI89_RS02945	COG2235	arginine
LI89_RS02950	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LI89_RS02955	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LI89_RS02965	COG2376	Dihydroxyacetone kinase
LI89_RS02970	COG1461	Dihydroxyacetone kinase
LI89_RS02975	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LI89_RS02975	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
LI89_RS02975	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LI89_RS02985	COG2192	nodulation
LI89_RS03015	COG3284	Transcriptional regulator
LI89_RS03050	COG4772	TonB-dependent receptor
LI89_RS03080	COG0667	Aldo Keto reductase
LI89_RS03085	COG2813	Specifically methylates the guanine in position
LI89_RS03090	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
LI89_RS03095	COG0456	acetyltransferase
LI89_RS03100	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
LI89_RS03105	COG2823	Periplasmic or secreted lipoprotein
LI89_RS03110	COG4667	esterase of the alpha-beta hydrolase superfamily
LI89_RS03115	COG0084	hydrolase, TatD family'
LI89_RS03120	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LI89_RS03130	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
LI89_RS03135	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
LI89_RS03140	COG0813	purine-nucleoside phosphorylase activity
LI89_RS03145	COG3726	membrane protein affecting hemolysin expression
LI89_RS03150	COG0560	Phosphoserine phosphatase
LI89_RS03180	COG0604	alcohol dehydrogenase
LI89_RS03190	COG0488	(ABC) transporter
LI89_RS03195	COG2885	chlorophyll binding
LI89_RS03200	COG2199	diguanylate cyclase activity
LI89_RS03210	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
LI89_RS03215	COG0741	lytic transglycosylase activity
LI89_RS03220	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
LI89_RS03225	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
LI89_RS03230	COG0406	alpha-ribazole phosphatase activity
LI89_RS03235	COG2207	Transcriptional regulator
LI89_RS03235	COG3708	Transcriptional regulator
LI89_RS03240	COG3045	CreA protein
LI89_RS03245	COG0745	RESPONSE REGULATOR receiver
LI89_RS03260	COG0083	homoserine kinase activity
LI89_RS03270	COG3022	response to hydroperoxide
LI89_RS03275	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LI89_RS03280	COG0521	Mo-molybdopterin cofactor biosynthetic process
LI89_RS03285	COG0477	Major facilitator Superfamily
LI89_RS03295	COG1584	GPR1 FUN34 yaaH family protein
LI89_RS03305	COG0484	heat shock protein binding
LI89_RS03310	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
LI89_RS03315	COG0583	DNA-binding transcription factor activity
LI89_RS03320	COG0268	Binds directly to 16S ribosomal RNA
LI89_RS03325	COG0196	riboflavin kinase activity
LI89_RS03330	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
LI89_RS03335	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
LI89_RS03340	COG1047	Peptidyl-prolyl cis-trans
LI89_RS03345	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
LI89_RS03350	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
LI89_RS03360	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LI89_RS03365	COG1280	lysine exporter protein (LysE YggA)
LI89_RS03370	COG2966	Psort location CytoplasmicMembrane, score
LI89_RS03375	COG3610	response to peptide
LI89_RS03380	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
LI89_RS03385	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
LI89_RS03390	COG2967	ApaG domain
LI89_RS03395	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LI89_RS03400	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
LI89_RS03410	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
LI89_RS03415	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
LI89_RS03420	COG0564	pseudouridine synthase activity
LI89_RS03430	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LI89_RS03435	COG0417	DNA replication proofreading
LI89_RS03440	COG0586	Pfam SNARE associated Golgi protein
LI89_RS03450	COG1178	ABC-type Fe3 transport system permease component
LI89_RS03455	COG4143	(ABC) transporter
LI89_RS03470	COG4533	DNA binding
LI89_RS03475	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
LI89_RS03480	COG1882	Formate acetyltransferase
LI89_RS03490	COG2814	Major facilitator Superfamily
LI89_RS03495	COG0814	amino acid
LI89_RS03500	COG3033	Beta-eliminating lyase
LI89_RS03515	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
LI89_RS03520	COG0473	3-isopropylmalate dehydrogenase activity
LI89_RS03525	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LI89_RS03535	COG1022	Amp-dependent synthetase and ligase
LI89_RS03540	COG0028	Belongs to the TPP enzyme family
LI89_RS03560	COG2001	Belongs to the MraZ family
LI89_RS03565	COG0275	rRNA processing
LI89_RS03570	COG3116	cell division
LI89_RS03575	COG0768	penicillin binding
LI89_RS03580	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LI89_RS03585	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LI89_RS03590	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LI89_RS03600	COG0772	Belongs to the SEDS family
LI89_RS03605	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LI89_RS03610	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LI89_RS03620	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
LI89_RS03625	COG0849	cell division
LI89_RS03630	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
LI89_RS03650	COG0653	protein targeting
LI89_RS03655	COG0494	nUDIX hydrolase
LI89_RS03660	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
LI89_RS03665	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
LI89_RS03675	COG0516	GMP reductase activity
LI89_RS03680	COG1459	type II secretion system
LI89_RS03685	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LI89_RS03690	COG4969	Belongs to the N-Me-Phe pilin family
LI89_RS03705	COG3725	Membrane protein required for beta-lactamase induction
LI89_RS03710	COG1113	amino acid transport
LI89_RS03715	COG2186	Transcriptional regulator
LI89_RS03720	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
LI89_RS03725	COG0508	dehydrogenase complex catalyzes the overall conversion of
LI89_RS03730	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LI89_RS03755	COG3112	Uncharacterised protein family (UPF0231)
LI89_RS03760	COG0697	spore germination
LI89_RS03765	COG3210	domain, Protein
LI89_RS03785	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
LI89_RS03790	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
LI89_RS03800	COG2132	Multicopper oxidase
LI89_RS03810	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
LI89_RS03815	COG0288	reversible hydration of carbon dioxide
LI89_RS03820	COG1131	(ABC) transporter
LI89_RS03825	COG0842	Transport permease protein
LI89_RS03830	COG0726	polysaccharide deacetylase
LI89_RS03835	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
LI89_RS03840	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
LI89_RS03845	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
LI89_RS03850	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
LI89_RS03870	COG1489	DNA binding
LI89_RS03875	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
LI89_RS03880	COG1643	Atp-dependent helicase
LI89_RS03885	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LI89_RS03890	COG1120	ATPase activity
LI89_RS03895	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LI89_RS03900	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LI89_RS03905	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
LI89_RS03915	COG0316	Belongs to the HesB IscA family
LI89_RS03920	COG2860	membrane
LI89_RS03930	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
LI89_RS03935	COG0232	Belongs to the dGTPase family. Type 2 subfamily
LI89_RS03940	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LI89_RS03945	COG3850	Histidine kinase
LI89_RS03945	COG4999	Histidine kinase
LI89_RS03945	COG2205	protein histidine kinase activity
LI89_RS03945	COG3437	response regulator, receiver
LI89_RS03950	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LI89_RS03955	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LI89_RS03960	COG3956	TIGRFAM MazG family protein
LI89_RS03965	COG0504	CTP synthase activity
LI89_RS03970	COG0148	phosphopyruvate hydratase activity
LI89_RS04000	COG0602	queuosine metabolic process
LI89_RS04005	COG0720	synthase
LI89_RS04010	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
LI89_RS04015	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LI89_RS04020	COG0175	sulfate reduction
LI89_RS04035	COG2234	aminopeptidase activity
LI89_RS04040	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LI89_RS04040	COG1648	precorrin-2 dehydrogenase activity
LI89_RS04045	COG0175	sulfate reduction
LI89_RS04050	COG2895	sulfate adenylyltransferase (ATP) activity
LI89_RS04055	COG0529	Catalyzes the synthesis of activated sulfate
LI89_RS04070	COG0765	amino acid transport
LI89_RS04080	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
LI89_RS04090	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
LI89_RS04095	COG0585	pseudouridine synthase activity
LI89_RS04100	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
LI89_RS04105	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
LI89_RS04110	COG1388	LysM domain
LI89_RS04110	COG4942	peptidase
LI89_RS04115	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LI89_RS04120	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
LI89_RS04145	COG3188	usher protein
LI89_RS04150	COG3121	Chaperone
LI89_RS04160	COG3539	Fimbrial protein
LI89_RS04165	COG3539	Fimbrial protein
LI89_RS04195	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LI89_RS04205	COG1538	Outer membrane efflux protein
LI89_RS04225	COG1028	Short-chain dehydrogenase reductase Sdr
LI89_RS04235	COG0583	DNA-binding transcription factor activity
LI89_RS04240	COG2610	gluconate transmembrane transporter activity
LI89_RS04245	COG3048	D-serine ammonia-lyase activity
LI89_RS04250	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LI89_RS04255	COG0765	amino acid transport
LI89_RS04260	COG0765	amino acid transport
LI89_RS04265	COG1126	abc transporter atp-binding protein
LI89_RS04270	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LI89_RS04275	COG3665	Urea carboxylase-associated protein
LI89_RS04290	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LI89_RS04295	COG0640	Transcriptional regulator
LI89_RS04350	COG0410	ABC transporter
LI89_RS04355	COG1137	ATPase activity
LI89_RS04360	COG4177	L-phenylalanine transmembrane transporter activity
LI89_RS04375	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
LI89_RS04375	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
LI89_RS04380	COG1070	Carbohydrate kinase
LI89_RS04385	COG3623	hexulose-6-phosphate isomerase
LI89_RS04395	COG1172	Belongs to the binding-protein-dependent transport system permease family
LI89_RS04410	COG1349	DNA-binding transcription factor activity
LI89_RS04420	COG1349	DNA-binding transcription factor activity
LI89_RS04430	COG1070	Carbohydrate kinase
LI89_RS04440	COG0738	Major facilitator superfamily
LI89_RS04445	COG0235	Class ii aldolase
LI89_RS04450	COG1454	alcohol dehydrogenase
LI89_RS04455	COG0243	molybdopterin cofactor binding
LI89_RS04460	COG0437	4 iron, 4 sulfur cluster binding
LI89_RS04465	COG3302	dmso reductase anchor subunit
LI89_RS04470	COG3381	protein complex oligomerization
LI89_RS04485	COG1879	ABC-type sugar transport system periplasmic component
LI89_RS04495	COG1129	ABC transporter
LI89_RS04500	COG1172	Belongs to the binding-protein-dependent transport system permease family
LI89_RS04505	COG3959	Transketolase, thiamine diphosphate binding domain
LI89_RS04510	COG3958	Transketolase
LI89_RS04515	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LI89_RS04540	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
LI89_RS04545	COG2137	regulation of response to DNA damage stimulus
LI89_RS04550	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LI89_RS04555	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
LI89_RS04590	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LI89_RS04595	COG1238	metal cluster binding
LI89_RS04600	COG2918	glutathione biosynthetic process
LI89_RS04605	COG1854	S-ribosylhomocysteine lyase activity
LI89_RS04610	COG4536	flavin adenine dinucleotide binding
LI89_RS04615	COG4137	Cytochrome C assembly protein
LI89_RS04620	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
LI89_RS04625	COG0228	four-way junction DNA binding
LI89_RS04630	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
LI89_RS04635	COG0336	Belongs to the RNA methyltransferase TrmD family
LI89_RS04640	COG0335	large ribosomal subunit rRNA binding
LI89_RS04645	COG3137	Salt-induced outer membrane protein
LI89_RS04650	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
LI89_RS04655	COG3279	Response regulator of the LytR AlgR family
LI89_RS04660	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LI89_RS04665	COG1605	Chorismate mutase
LI89_RS04665	COG0287	Prephenate dehydrogenase
LI89_RS04670	COG0077	Prephenate dehydratase
LI89_RS04670	COG1605	Chorismate mutase
LI89_RS04675	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
LI89_RS04680	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LI89_RS04685	COG0564	pseudouridine synthase activity
LI89_RS04690	COG1496	oxidoreductase activity
LI89_RS04695	COG0542	response to heat
LI89_RS04735	COG5544	Lipoprotein
LI89_RS04740	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LI89_RS04745	COG0045	succinate-CoA ligase (ADP-forming) activity
LI89_RS04745	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LI89_RS04745	COG1042	CoA-binding domain protein
LI89_RS04750	COG3148	PFAM DTW domain containing protein
LI89_RS04755	COG3118	belongs to the thioredoxin family
LI89_RS04760	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LI89_RS04765	COG2814	Major facilitator Superfamily
LI89_RS04770	COG1566	PFAM secretion protein HlyD family protein
LI89_RS04775	COG1538	Outer membrane efflux protein
LI89_RS04780	COG1846	Transcriptional regulator
LI89_RS04790	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
LI89_RS04795	COG2814	Major facilitator Superfamily
LI89_RS04830	COG0765	amino acid transport
LI89_RS04835	COG0765	amino acid transport
LI89_RS04845	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
LI89_RS04860	COG0436	Aminotransferase
LI89_RS04865	COG0235	Class ii aldolase
LI89_RS04870	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
LI89_RS04875	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
LI89_RS04880	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
LI89_RS04885	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
LI89_RS04900	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
LI89_RS04905	COG1960	acyl-CoA dehydrogenase activity
LI89_RS04910	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
LI89_RS04915	COG0121	glutamine amidotransferase
LI89_RS04920	COG3034	peptidoglycan biosynthetic process
LI89_RS04925	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
LI89_RS04930	COG1805	sodium ion transport
LI89_RS04935	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
LI89_RS04940	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
LI89_RS04945	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
LI89_RS04950	COG2871	sodium ion transport
LI89_RS04955	COG1477	protein flavinylation
LI89_RS04960	COG2991	Protein conserved in bacteria
LI89_RS04975	COG2964	Protein conserved in bacteria
LI89_RS04990	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LI89_RS04995	COG2195	Cleaves the N-terminal amino acid of tripeptides
LI89_RS05000	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
LI89_RS05005	COG1073	alpha beta
LI89_RS05015	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
LI89_RS05020	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
LI89_RS05025	COG2188	Transcriptional regulator
LI89_RS05045	COG3459	Glycosyltransferase 36 associated
LI89_RS05060	COG2226	methyltransferase
LI89_RS05085	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
LI89_RS05090	COG3123	guanosine phosphorylase activity
LI89_RS05095	COG2974	May be involved in recombination
LI89_RS05100	COG1940	carbohydrate kinase activity
LI89_RS05105	COG0419	ATPase involved in DNA repair
LI89_RS05110	COG0420	3'-5' exonuclease activity
LI89_RS05115	COG0745	RESPONSE REGULATOR receiver
LI89_RS05120	COG5002	protein histidine kinase activity
LI89_RS05140	COG0366	Alpha amylase catalytic
LI89_RS05155	COG0450	alkyl hydroperoxide reductase
LI89_RS05160	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
LI89_RS05165	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
LI89_RS05175	COG0343	queuine tRNA-ribosyltransferase activity
LI89_RS05180	COG1862	Preprotein translocase
LI89_RS05185	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LI89_RS05190	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LI89_RS05200	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
LI89_RS05205	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LI89_RS05205	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LI89_RS05210	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
LI89_RS05215	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LI89_RS05220	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
LI89_RS05225	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
LI89_RS05230	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
LI89_RS05235	COG0142	geranyltranstransferase activity
LI89_RS05240	COG1722	exodeoxyribonuclease VII activity
LI89_RS05245	COG0301	tRNA thio-modification
LI89_RS05245	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LI89_RS05255	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
LI89_RS05260	COG1666	GTP binding
LI89_RS05265	COG2814	Major facilitator Superfamily
LI89_RS05270	COG0109	protoheme IX farnesyltransferase activity
LI89_RS05275	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
LI89_RS05280	COG1845	cytochrome c oxidase, subunit III
LI89_RS05285	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LI89_RS05290	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
LI89_RS05300	COG2223	nitrite transmembrane transporter activity
LI89_RS05305	COG3056	Lipoprotein
LI89_RS05310	COG0271	Belongs to the BolA IbaG family
LI89_RS05315	COG0544	peptidyl-prolyl cis-trans isomerase activity
LI89_RS05320	COG0740	serine-type endopeptidase activity
LI89_RS05325	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
LI89_RS05330	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
LI89_RS05335	COG0776	regulation of translation
LI89_RS05340	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LI89_RS05345	COG1555	photosystem II stabilization
LI89_RS05350	COG0824	Thioesterase
LI89_RS05355	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
LI89_RS05360	COG4533	DNA binding
LI89_RS05365	COG0561	phosphatase activity
LI89_RS05375	COG1522	sequence-specific DNA binding
LI89_RS05380	COG1132	(ABC) transporter
LI89_RS05385	COG1132	(ABC) transporter
LI89_RS05390	COG0347	Belongs to the P(II) protein family
LI89_RS05395	COG0004	ammonium transporteR
LI89_RS05400	COG1946	Acyl-CoA thioesterase
LI89_RS05405	COG3126	Type III secretion system lipoprotein chaperone (YscW)
LI89_RS05410	COG3695	enzyme binding
LI89_RS05445	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LI89_RS05450	COG0803	Belongs to the bacterial solute-binding protein 9 family
LI89_RS05455	COG0257	Belongs to the bacterial ribosomal protein bL36 family
LI89_RS05460	COG0254	rRNA binding
LI89_RS05475	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
LI89_RS05480	COG3457	Alanine racemase
LI89_RS05490	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LI89_RS05495	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LI89_RS05500	COG1309	transcriptional regulator
LI89_RS05505	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
LI89_RS05510	COG3264	Mechanosensitive ion channel
LI89_RS05510	COG1196	nuclear chromosome segregation
LI89_RS05525	COG2832	Protein of unknown function (DUF454)
LI89_RS05530	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LI89_RS05540	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
LI89_RS05545	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
LI89_RS05550	COG0326	Molecular chaperone. Has ATPase activity
LI89_RS05555	COG0563	adenylate kinase activity
LI89_RS05560	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
LI89_RS05565	COG2244	polysaccharide biosynthetic process
LI89_RS05570	COG1216	Glycosyl transferase, family 2
LI89_RS05570	COG1442	glycosyl transferase family 8
LI89_RS05575	COG1442	glycosyl transferase family 8
LI89_RS05575	COG1216	Glycosyl transferase, family 2
LI89_RS05580	COG0438	transferase activity, transferring glycosyl groups
LI89_RS05585	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LI89_RS05610	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LI89_RS05615	COG4651	solute:proton antiporter activity
LI89_RS05615	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LI89_RS05620	COG2223	nitrite transmembrane transporter activity
LI89_RS05625	COG0737	Belongs to the 5'-nucleotidase family
LI89_RS05630	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
LI89_RS05635	COG3735	TraB family
LI89_RS05640	COG2217	Heavy metal translocating P-type atpase
LI89_RS05645	COG0789	Transcriptional regulator
LI89_RS05650	COG1585	Membrane protein implicated in regulation of membrane protease activity
LI89_RS05655	COG0330	HflC and HflK could
LI89_RS05660	COG3118	belongs to the thioredoxin family
LI89_RS05665	COG0300	oxidoreductase activity
LI89_RS05670	COG2755	lipolytic protein G-D-S-L family
LI89_RS05675	COG4181	ATPase activity
LI89_RS05680	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
LI89_RS05685	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
LI89_RS05690	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
LI89_RS05695	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LI89_RS05700	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LI89_RS05705	COG0215	cysteine-tRNA ligase activity
LI89_RS05710	COG2501	S4 domain
LI89_RS05715	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
LI89_RS05730	COG1902	pentaerythritol trinitrate reductase activity
LI89_RS05745	COG0656	L-ascorbic acid biosynthetic process
LI89_RS05765	COG5002	protein histidine kinase activity
LI89_RS05785	COG2850	peptidyl-arginine hydroxylation
LI89_RS05790	COG2986	histidine ammonia-lyase
LI89_RS05800	COG5265	(ABC) transporter
LI89_RS05815	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
LI89_RS05825	COG2197	response regulator
LI89_RS05830	COG1278	Cold shock
LI89_RS05845	COG3706	GGDEF domain
LI89_RS05850	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LI89_RS05855	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
LI89_RS05860	COG0321	lipoyl(octanoyl) transferase activity
LI89_RS05865	COG2921	Belongs to the UPF0250 family
LI89_RS05870	COG1686	Belongs to the peptidase S11 family
LI89_RS05875	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
LI89_RS05880	COG0772	Belongs to the SEDS family
LI89_RS05885	COG0768	penicillin binding
LI89_RS05895	COG0799	negative regulation of ribosome biogenesis
LI89_RS05900	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
LI89_RS05905	COG1466	dna polymerase III delta subunit
LI89_RS05910	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
LI89_RS05915	COG0495	leucyl-tRNA aminoacylation
LI89_RS05920	COG2888	peptidyl-tyrosine sulfation
LI89_RS05930	COG1126	abc transporter atp-binding protein
LI89_RS05935	COG0765	amino acid transport
LI89_RS05940	COG0765	amino acid transport
LI89_RS05955	COG0815	Transfers the fatty acyl group on membrane lipoproteins
LI89_RS05960	COG4535	Mg2 and Co2 transporter CorC
LI89_RS05965	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
LI89_RS05970	COG1702	phosphate starvation-inducible protein PhoH
LI89_RS05975	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LI89_RS05980	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LI89_RS06015	COG0367	asparagine synthase
LI89_RS06020	COG0647	UMP catabolic process
LI89_RS06025	COG1940	carbohydrate kinase activity
LI89_RS06025	COG1846	Transcriptional regulator
LI89_RS06030	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
LI89_RS06035	COG0363	glucosamine-6-phosphate deaminase activity
LI89_RS06040	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LI89_RS06040	COG1263	PTS System
LI89_RS06040	COG2190	(PTS) system
LI89_RS06045	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LI89_RS06065	COG0735	belongs to the Fur family
LI89_RS06075	COG0840	transmembrane signaling receptor activity
LI89_RS06085	COG0596	Alpha beta hydrolase
LI89_RS06090	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
LI89_RS06095	COG0033	Phosphoglucomutase
LI89_RS06110	COG0745	RESPONSE REGULATOR receiver
LI89_RS06115	COG2205	protein histidine kinase activity
LI89_RS06120	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
LI89_RS06125	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
LI89_RS06130	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
LI89_RS06150	COG2994	toxin metabolic process
LI89_RS06155	COG3064	Membrane
LI89_RS06155	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
LI89_RS06155	COG1073	alpha beta
LI89_RS06155	COG3064	Membrane
LI89_RS06155	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
LI89_RS06155	COG1073	alpha beta
LI89_RS06160	COG3272	Protein of unknown function (DUF1722)
LI89_RS06170	COG5212	phosphodiesterase
LI89_RS06175	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
LI89_RS06180	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
LI89_RS06185	COG1984	allophanate hydrolase subunit 2
LI89_RS06190	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
LI89_RS06205	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
LI89_RS06215	COG2009	succinate dehydrogenase
LI89_RS06220	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
LI89_RS06225	COG1053	succinate dehydrogenase
LI89_RS06235	COG0567	Dehydrogenase, E1 component
LI89_RS06240	COG0508	dehydrogenase complex catalyzes the overall conversion of
LI89_RS06245	COG0045	succinate-CoA ligase (ADP-forming) activity
LI89_RS06250	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
LI89_RS06255	COG0737	Belongs to the 5'-nucleotidase family
LI89_RS06260	COG1271	oxidase subunit
LI89_RS06265	COG1294	oxidase, subunit
LI89_RS06270	COG4890	Cyd operon protein YbgT
LI89_RS06275	COG3790	cyd operon protein YbgE
LI89_RS06280	COG0824	Thioesterase
LI89_RS06285	COG0811	peptide transport
LI89_RS06290	COG0848	biopolymer transport protein
LI89_RS06295	COG3064	Membrane
LI89_RS06295	COG3064	Membrane
LI89_RS06300	COG0823	Involved in the tonB-independent uptake of proteins
LI89_RS06305	COG2885	chlorophyll binding
LI89_RS06310	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
LI89_RS06355	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
LI89_RS06365	COG1230	cation diffusion facilitator family transporter
LI89_RS06370	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LI89_RS06375	COG0588	phosphoglycerate mutase activity
LI89_RS06390	COG2017	converts alpha-aldose to the beta-anomer
LI89_RS06395	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
LI89_RS06400	COG1085	galactose-1-phosphate uridylyltransferase
LI89_RS06405	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LI89_RS06415	COG1119	ATPase activity
LI89_RS06420	COG3585	molybdate ion transport
LI89_RS06420	COG2005	Transcriptional regulator
LI89_RS06430	COG0725	ABC transporter, periplasmic molybdate-binding protein
LI89_RS06435	COG4149	molybdate abc transporter
LI89_RS06445	COG0561	phosphatase activity
LI89_RS06450	COG2706	6-phosphogluconolactonase activity
LI89_RS06460	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
LI89_RS06465	COG0156	8-amino-7-oxononanoate synthase activity
LI89_RS06470	COG2226	methyltransferase
LI89_RS06485	COG0556	nucleotide-excision repair
LI89_RS06490	COG4628	conserved protein (DUF2132)
LI89_RS06495	COG0391	Required for morphogenesis under gluconeogenic growth conditions
LI89_RS06500	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
LI89_RS06505	COG0315	cyclic pyranopterin monophosphate synthase activity
LI89_RS06510	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
LI89_RS06515	COG0314	molybdopterin synthase activity
LI89_RS06520	COG0670	Belongs to the BI1 family
LI89_RS06525	COG0842	Transport permease protein
LI89_RS06530	COG0842	Transport permease protein
LI89_RS06535	COG1131	(ABC) transporter
LI89_RS06540	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LI89_RS06545	COG1309	transcriptional regulator
LI89_RS06550	COG0513	Belongs to the DEAD box helicase family
LI89_RS06555	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LI89_RS06565	COG1686	Belongs to the peptidase S11 family
LI89_RS06570	COG0277	FAD linked oxidase domain protein
LI89_RS06590	COG2261	transglycosylase associated protein
LI89_RS06600	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
LI89_RS06615	COG4807	Protein conserved in bacteria
LI89_RS06645	COG2897	thiosulfate sulfurtransferase activity
LI89_RS06660	COG1732	Glycine betaine
LI89_RS06665	COG1174	glycine betaine transport
LI89_RS06670	COG1125	glycine betaine transport
LI89_RS06675	COG1174	glycine betaine transport
LI89_RS06690	COG0583	DNA-binding transcription factor activity
LI89_RS06700	COG0697	spore germination
LI89_RS06720	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LI89_RS06725	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LI89_RS06745	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
LI89_RS06755	COG1126	abc transporter atp-binding protein
LI89_RS06760	COG0765	amino acid transport
LI89_RS06765	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LI89_RS06770	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
LI89_RS06775	COG0783	Belongs to the Dps family
LI89_RS06780	COG4106	trans-aconitate 2-methyltransferase activity
LI89_RS06795	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
LI89_RS06815	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
LI89_RS06835	COG0488	(ABC) transporter
LI89_RS06840	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
LI89_RS06845	COG0303	'Molybdopterin
LI89_RS06860	COG0577	efflux transmembrane transporter activity
LI89_RS06860	COG1136	(ABC) transporter
LI89_RS06890	COG0583	DNA-binding transcription factor activity
LI89_RS06895	COG0477	Major facilitator Superfamily
LI89_RS06900	COG0302	gtp cyclohydrolase
LI89_RS06905	COG2311	Membrane
LI89_RS06930	COG2116	formate transmembrane transporter activity
LI89_RS06935	COG3604	Transcriptional regulator
LI89_RS06940	COG3383	formate dehydrogenase (NAD+) activity
LI89_RS06945	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
LI89_RS06950	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
LI89_RS06960	COG3260	NADH ubiquinone oxidoreductase 20
LI89_RS06965	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LI89_RS06970	COG3261	NADH dehydrogenase
LI89_RS06970	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
LI89_RS06975	COG0651	ATP synthesis coupled electron transport
LI89_RS06980	COG4237	Hydrogenase 4 membrane
LI89_RS06985	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LI89_RS06990	COG0650	Formate hydrogenlyase subunit 4
LI89_RS06995	COG0651	ATP synthesis coupled electron transport
LI89_RS07000	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
LI89_RS07005	COG0375	protein maturation
LI89_RS07010	COG0298	carbon dioxide binding
LI89_RS07015	COG2949	membrane
LI89_RS07020	COG0281	malic enzyme
LI89_RS07035	COG1346	cytolysis
LI89_RS07040	COG1380	Effector of murein hydrolase LrgA
LI89_RS07045	COG2814	Major facilitator Superfamily
LI89_RS07065	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LI89_RS07065	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LI89_RS07070	COG0489	protein tyrosine kinase activity
LI89_RS07075	COG0572	uridine kinase
LI89_RS07085	COG2982	Protein involved in outer membrane biogenesis
LI89_RS07090	COG3069	C4-dicarboxylate transmembrane transporter activity
LI89_RS07095	COG1253	flavin adenine dinucleotide binding
LI89_RS07100	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LI89_RS07105	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LI89_RS07110	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
LI89_RS07115	COG0140	phosphoribosyl-ATP diphosphatase activity
LI89_RS07115	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
LI89_RS07120	COG0107	imidazoleglycerol-phosphate synthase activity
LI89_RS07125	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
LI89_RS07135	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
LI89_RS07135	COG0131	Imidazoleglycerol-phosphate dehydratase
LI89_RS07140	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LI89_RS07150	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
LI89_RS07155	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LI89_RS07160	COG1172	Belongs to the binding-protein-dependent transport system permease family
LI89_RS07165	COG1129	ABC transporter
LI89_RS07175	COG1129	ABC transporter
LI89_RS07180	COG0371	Dehydrogenase
LI89_RS07190	COG0531	amino acid
LI89_RS07195	COG2925	Exonuclease
LI89_RS07200	COG3320	Male sterility
LI89_RS07200	COG1022	Amp-dependent synthetase and ligase
LI89_RS07205	COG1289	transmembrane transporter activity
LI89_RS07210	COG2926	Belongs to the UPF0265 family
LI89_RS07220	COG1172	Belongs to the binding-protein-dependent transport system permease family
LI89_RS07240	COG2197	response regulator
LI89_RS07250	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LI89_RS07255	COG1648	precorrin-2 dehydrogenase activity
LI89_RS07255	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LI89_RS07260	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
LI89_RS07280	COG4656	Part of a membrane complex involved in electron transport
LI89_RS07295	COG2096	Adenosyltransferase
LI89_RS07300	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
LI89_RS07375	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
LI89_RS07385	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
LI89_RS07450	COG1492	cobalamin metabolic process
LI89_RS07470	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
LI89_RS07475	COG0583	DNA-binding transcription factor activity
LI89_RS07485	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
LI89_RS07490	COG2211	Major facilitator Superfamily
LI89_RS07550	COG3121	Chaperone
LI89_RS07555	COG3188	usher protein
LI89_RS07620	COG0137	argininosuccinate synthase activity
LI89_RS07625	COG0534	Mate efflux family protein
LI89_RS07635	COG0352	thiamine-phosphate diphosphorylase activity
LI89_RS07640	COG0561	phosphatase activity
LI89_RS07645	COG1349	DNA-binding transcription factor activity
LI89_RS07655	COG0835	chemotaxis
LI89_RS07655	COG0784	Response regulator, receiver
LI89_RS07665	COG4221	oxidoreductase activity
LI89_RS07675	COG1129	ABC transporter
LI89_RS07695	COG4214	carbohydrate transport
LI89_RS07705	COG1063	alcohol dehydrogenase
LI89_RS07730	COG3121	Chaperone
LI89_RS07755	COG2205	protein histidine kinase activity
LI89_RS07755	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LI89_RS07815	COG3842	ATPase activity
LI89_RS07825	COG1840	ABC-type Fe3 transport system, periplasmic component
LI89_RS07830	COG2271	Major facilitator Superfamily
LI89_RS07845	COG4565	transcriptional regulatory protein
LI89_RS07850	COG3290	protein histidine kinase activity
LI89_RS07855	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
LI89_RS07860	COG3052	prosthetic group binding
LI89_RS07865	COG2301	Belongs to the HpcH HpaI aldolase family
LI89_RS07870	COG3051	citrate lyase alpha subunit
LI89_RS07885	COG0471	metal ion transport
LI89_RS07900	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
LI89_RS07915	COG2814	Major facilitator Superfamily
LI89_RS07920	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
LI89_RS07920	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LI89_RS07945	COG1136	(ABC) transporter
LI89_RS07945	COG0577	efflux transmembrane transporter activity
LI89_RS07950	COG1136	(ABC) transporter
LI89_RS07950	COG0577	efflux transmembrane transporter activity
LI89_RS07955	COG3122	Protein conserved in bacteria
LI89_RS07970	COG3228	Belongs to the MtfA family
LI89_RS07980	COG1129	ABC transporter
LI89_RS07985	COG1172	Belongs to the binding-protein-dependent transport system permease family
LI89_RS07990	COG1172	Belongs to the binding-protein-dependent transport system permease family
LI89_RS08000	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LI89_RS08005	COG1070	Carbohydrate kinase
LI89_RS08030	COG3121	Chaperone
LI89_RS08035	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
LI89_RS08065	COG3321	synthase
LI89_RS08065	COG0604	alcohol dehydrogenase
LI89_RS08065	COG1028	Short-chain dehydrogenase reductase Sdr
LI89_RS08070	COG3250	beta-galactosidase activity
LI89_RS08075	COG1609	Transcriptional regulator
LI89_RS08090	COG0840	transmembrane signaling receptor activity
LI89_RS08095	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LI89_RS08100	COG1285	pathogenesis
LI89_RS08110	COG2130	NADP-dependent
LI89_RS08115	COG0589	response to stress
LI89_RS08135	COG1360	Flagellar Motor Protein
LI89_RS08140	COG2198	Histidine kinase
LI89_RS08140	COG0643	Histidine kinase
LI89_RS08145	COG0835	chemotaxis
LI89_RS08150	COG0840	transmembrane signaling receptor activity
LI89_RS08155	COG0840	transmembrane signaling receptor activity
LI89_RS08160	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
LI89_RS08170	COG0745	RESPONSE REGULATOR receiver
LI89_RS08175	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
LI89_RS08180	COG4935	Belongs to the peptidase S8 family
LI89_RS08180	COG1404	Belongs to the peptidase S8 family
LI89_RS08185	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
LI89_RS08190	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
LI89_RS08205	COG3418	PFAM FlgN family protein
LI89_RS08210	COG2747	anti-sigma28 factor FlgM
LI89_RS08220	COG1815	bacterial-type flagellum-dependent cell motility
LI89_RS08225	COG1558	bacterial-type flagellum-dependent cell motility
LI89_RS08230	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
LI89_RS08235	COG1749	Flagellar hook protein flgE
LI89_RS08265	COG1256	bacterial-type flagellum assembly
LI89_RS08285	COG1338	Plays a role in the flagellum-specific transport system
LI89_RS08305	COG1580	Controls the rotational direction of flagella during chemotaxis
LI89_RS08325	COG1317	bacterial-type flagellum organization
LI89_RS08340	COG1677	Flagellar hook-basal body complex protein FliE
LI89_RS08345	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
LI89_RS08350	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
LI89_RS08400	COG1191	sigma factor activity
LI89_RS08410	COG2515	1-aminocyclopropane-1-carboxylate deaminase
LI89_RS08415	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LI89_RS08420	COG0765	amino acid transport
LI89_RS08425	COG1126	abc transporter atp-binding protein
LI89_RS08440	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
LI89_RS08440	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
LI89_RS08440	COG0506	proline dehydrogenase activity
LI89_RS08450	COG0672	)-iron permease
LI89_RS08455	COG2822	iron ion transport
LI89_RS08465	COG0655	NAD(P)H dehydrogenase (quinone) activity
LI89_RS08475	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
LI89_RS08480	COG2233	PERMEase
LI89_RS08485	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LI89_RS08490	COG0778	Nitroreductase
LI89_RS08495	COG2267	carboxylic ester hydrolase activity
LI89_RS08500	COG0251	oxidation-reduction process
LI89_RS08505	COG1335	isochorismatase
LI89_RS08510	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LI89_RS08515	COG1309	transcriptional regulator
LI89_RS08520	COG1113	amino acid transport
LI89_RS08540	COG2226	methyltransferase
LI89_RS08555	COG0366	Alpha amylase catalytic
LI89_RS08565	COG3136	membrane protein required for alginate biosynthesis
LI89_RS08575	COG2197	response regulator
LI89_RS08580	COG0322	excinuclease ABC activity
LI89_RS08585	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LI89_RS08730	COG4695	Portal protein
LI89_RS08800	COG4974	Belongs to the 'phage' integrase family
LI89_RS08880	COG0305	Participates in initiation and elongation during chromosome replication
LI89_RS08935	COG3772	lysozyme
LI89_RS09025	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
LI89_RS09115	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
LI89_RS09130	COG0561	phosphatase activity
LI89_RS09135	COG2223	nitrite transmembrane transporter activity
LI89_RS09145	COG0346	lactoylglutathione lyase activity
LI89_RS09165	COG3493	citrate carrier protein
LI89_RS09170	COG4565	transcriptional regulatory protein
LI89_RS09175	COG3290	protein histidine kinase activity
LI89_RS09180	COG1349	DNA-binding transcription factor activity
LI89_RS09185	COG3395	kinase activity
LI89_RS09190	COG0235	Class ii aldolase
LI89_RS09195	COG3622	Belongs to the hyi family
LI89_RS09200	COG2066	Belongs to the glutaminase family
LI89_RS09215	COG0672	)-iron permease
LI89_RS09230	COG0577	efflux transmembrane transporter activity
LI89_RS09230	COG1136	(ABC) transporter
LI89_RS09240	COG1136	(ABC) transporter
LI89_RS09240	COG0577	efflux transmembrane transporter activity
LI89_RS09265	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LI89_RS09270	COG4114	ferric iron reductase
LI89_RS09275	COG0006	proline dipeptidase activity
LI89_RS09280	COG0457	Tetratricopeptide repeat
LI89_RS09285	COG0726	polysaccharide deacetylase
LI89_RS09285	COG1649	PFAM Uncharacterised BCR, COG1649
LI89_RS09290	COG1215	transferase activity, transferring glycosyl groups
LI89_RS09295	COG3658	cytochrome
LI89_RS09310	COG1702	phosphate starvation-inducible protein PhoH
LI89_RS09315	COG0387	Pfam Sodium calcium exchanger
LI89_RS09325	COG2814	Major facilitator Superfamily
LI89_RS09330	COG0583	DNA-binding transcription factor activity
LI89_RS09335	COG3850	Histidine kinase
LI89_RS09340	COG1294	oxidase, subunit
LI89_RS09345	COG1271	oxidase subunit
LI89_RS09350	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LI89_RS09355	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LI89_RS09360	COG3138	arginine N-succinyltransferase
LI89_RS09370	COG3724	N-succinylarginine dihydrolase activity
LI89_RS09375	COG2988	succinylglutamate desuccinylase activity
LI89_RS09390	COG1228	amidohydrolase
LI89_RS09400	COG0402	S-adenosylhomocysteine deaminase activity
LI89_RS09410	COG3443	Belongs to the bacterial solute-binding protein 9 family
LI89_RS09420	COG4942	peptidase
LI89_RS09430	COG2222	sugar isomerase
LI89_RS09435	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
LI89_RS09440	COG3716	PTS system mannose fructose sorbose family IID component
LI89_RS09450	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LI89_RS09460	COG1349	DNA-binding transcription factor activity
LI89_RS09475	COG1187	pseudouridine synthase activity
LI89_RS09480	COG0786	glutamate:sodium symporter activity
LI89_RS09500	COG0668	transmembrane transport
LI89_RS09505	COG0625	glutathione transferase activity
LI89_RS09530	COG3706	GGDEF domain
LI89_RS09530	COG4251	negative regulation of phosphorylation
LI89_RS09530	COG5001	Diguanylate cyclase
LI89_RS09530	COG2203	Gaf domain
LI89_RS09565	COG2814	Major facilitator Superfamily
LI89_RS09575	COG3008	intermembrane lipid transfer
LI89_RS09580	COG2995	paraquat-inducible protein a
LI89_RS09585	COG1956	GAF domain-containing protein
LI89_RS09595	COG0793	Belongs to the peptidase S41A family
LI89_RS09600	COG0501	Belongs to the peptidase M48B family
LI89_RS09625	COG2814	Major facilitator Superfamily
LI89_RS09630	COG0823	Involved in the tonB-independent uptake of proteins
LI89_RS09640	COG3023	N-Acetylmuramoyl-L-alanine amidase
LI89_RS09645	COG1823	symporter activity
LI89_RS09650	COG1988	membrane-bound metal-dependent
LI89_RS09660	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
LI89_RS09665	COG1653	transport
LI89_RS09670	COG3842	ATPase activity
LI89_RS09675	COG0395	ABC-type sugar transport system, permease component
LI89_RS09680	COG1175	transmembrane transport
LI89_RS09695	COG1028	Short-chain dehydrogenase reductase Sdr
LI89_RS09700	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
LI89_RS09705	COG1917	Cupin 2, conserved barrel domain protein
LI89_RS09710	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LI89_RS09720	COG0583	DNA-binding transcription factor activity
LI89_RS09725	COG0427	acetyl-CoA hydrolase
LI89_RS09730	COG1024	Enoyl-CoA hydratase
LI89_RS09735	COG1703	isobutyryl-CoA mutase activity
LI89_RS09740	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LI89_RS09740	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LI89_RS09745	COG3001	Fructosamine kinase
LI89_RS09750	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LI89_RS09755	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LI89_RS09760	COG1121	(ABC) transporter
LI89_RS09765	COG0803	Belongs to the bacterial solute-binding protein 9 family
LI89_RS09800	COG1811	Na channel or pump
LI89_RS09805	COG4249	Peptidase C14 caspase catalytic subunit p20
LI89_RS09810	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
LI89_RS09815	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
LI89_RS09820	COG0291	Belongs to the bacterial ribosomal protein bL35 family
LI89_RS09825	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
LI89_RS09830	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
LI89_RS09840	COG0776	regulation of translation
LI89_RS09850	COG4139	cobalamin transport
LI89_RS09855	COG0386	Belongs to the glutathione peroxidase family
LI89_RS09860	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
LI89_RS09865	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LI89_RS09870	COG0463	Glycosyl transferase, family 2
LI89_RS09875	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LI89_RS09875	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LI89_RS09880	COG0726	polysaccharide deacetylase
LI89_RS09885	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
LI89_RS09890	COG2076	Multidrug Resistance protein
LI89_RS09895	COG2076	Multidrug Resistance protein
LI89_RS09900	COG0791	NLP P60 protein
LI89_RS09905	COG0095	Lipoate-protein ligase
LI89_RS09915	COG4558	Periplasmic binding protein
LI89_RS09920	COG3720	iron ion transport
LI89_RS09925	COG4771	TonB-dependent receptor
LI89_RS09940	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
LI89_RS09945	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LI89_RS09945	COG0574	Belongs to the PEP-utilizing enzyme family
LI89_RS09955	COG0628	permease
LI89_RS09960	COG0277	FAD linked oxidase domain protein
LI89_RS09960	COG0247	lactate metabolic process
LI89_RS09965	COG2050	protein possibly involved in aromatic compounds catabolism
LI89_RS09970	COG0316	Belongs to the HesB IscA family
LI89_RS09975	COG0719	Fe-S assembly protein
LI89_RS09980	COG0396	ATPase activity
LI89_RS09985	COG0719	Fe-S assembly protein
LI89_RS09995	COG2166	iron-sulfur cluster assembly
LI89_RS10000	COG1376	ErfK ybiS ycfS ynhG family protein
LI89_RS10000	COG1388	LysM domain
LI89_RS10030	COG0534	Mate efflux family protein
LI89_RS10035	COG0307	riboflavin synthase, alpha
LI89_RS10040	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LI89_RS10045	COG2814	Major facilitator Superfamily
LI89_RS10050	COG0583	DNA-binding transcription factor activity
LI89_RS10055	COG1609	Transcriptional regulator
LI89_RS10065	COG0791	NLP P60 protein
LI89_RS10070	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
LI89_RS10075	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LI89_RS10080	COG0346	lactoylglutathione lyase activity
LI89_RS10085	COG1902	pentaerythritol trinitrate reductase activity
LI89_RS10090	COG1309	transcriptional regulator
LI89_RS10095	COG2194	sulfuric ester hydrolase activity
LI89_RS10100	COG3313	Fe-S protein
LI89_RS10105	COG4989	oxidoreductase activity
LI89_RS10110	COG1289	transmembrane transporter activity
LI89_RS10115	COG1566	PFAM secretion protein HlyD family protein
LI89_RS10125	COG1846	Transcriptional regulator
LI89_RS10130	COG3133	Outer membrane lipoprotein
LI89_RS10135	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
LI89_RS10140	COG3895	Periplasmic Protein
LI89_RS10145	COG0259	pyridoxamine-phosphate oxidase activity
LI89_RS10150	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
LI89_RS10160	COG0625	glutathione transferase activity
LI89_RS10180	COG3104	oligopeptide transport
LI89_RS10190	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LI89_RS10190	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LI89_RS10200	COG4172	Belongs to the ABC transporter superfamily
LI89_RS10210	COG4171	peptide transport system, permease
LI89_RS10220	COG4166	transmembrane transport
LI89_RS10235	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
LI89_RS10240	COG1842	Phage shock protein A
LI89_RS10250	COG1983	PspC domain protein
LI89_RS10260	COG3106	COG3106 Predicted ATPase
LI89_RS10265	COG3768	UPF0283 membrane protein
LI89_RS10270	COG5654	RES domain protein
LI89_RS10275	COG5642	Protein of unknown function (DUF2384)
LI89_RS10285	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
LI89_RS10290	COG4948	Mandelate Racemase Muconate Lactonizing
LI89_RS10295	COG2866	Carboxypeptidase
LI89_RS10300	COG4166	transmembrane transport
LI89_RS10315	COG0598	Magnesium transport protein CorA
LI89_RS10320	COG0037	tRNA processing
LI89_RS10325	COG3711	transcriptional antiterminator
LI89_RS10330	COG1263	PTS System
LI89_RS10330	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LI89_RS10330	COG2190	(PTS) system
LI89_RS10335	COG2723	6-phospho-beta-galactosidase activity
LI89_RS10340	COG0674	pyruvate-flavodoxin oxidoreductase activity
LI89_RS10340	COG1013	pyruvate-flavodoxin oxidoreductase activity
LI89_RS10340	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
LI89_RS10340	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LI89_RS10350	COG1285	pathogenesis
LI89_RS10355	COG3042	response to heat
LI89_RS10360	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LI89_RS10365	COG2911	Protein conserved in bacteria
LI89_RS10375	COG3784	Protein of unknown function (DUF1318)
LI89_RS10385	COG1070	Carbohydrate kinase
LI89_RS10390	COG0246	Mannitol dehydrogenase
LI89_RS10400	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
LI89_RS10405	COG1643	Atp-dependent helicase
LI89_RS10420	COG3591	Belongs to the peptidase S1B family
LI89_RS10430	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
LI89_RS10435	COG2205	protein histidine kinase activity
LI89_RS10440	COG0745	RESPONSE REGULATOR receiver
LI89_RS10450	COG0531	amino acid
LI89_RS10465	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
LI89_RS10470	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
LI89_RS10475	COG0589	response to stress
LI89_RS10480	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LI89_RS10485	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LI89_RS10500	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
LI89_RS10510	COG1028	Short-chain dehydrogenase reductase Sdr
LI89_RS10520	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LI89_RS10525	COG0738	Major facilitator superfamily
LI89_RS10545	COG1011	Hydrolase
LI89_RS10550	COG0440	acetolactate synthase activity
LI89_RS10555	COG0028	Belongs to the TPP enzyme family
LI89_RS10575	COG2271	Major facilitator Superfamily
LI89_RS10580	COG0483	inositol monophosphate 1-phosphatase activity
LI89_RS10590	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
LI89_RS10600	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LI89_RS10625	COG1522	sequence-specific DNA binding
LI89_RS10635	COG0446	pyridine nucleotide-disulphide oxidoreductase
LI89_RS10640	COG0426	domain, Protein
LI89_RS10640	COG1773	rubredoxin
LI89_RS10645	COG3604	Transcriptional regulator
LI89_RS10665	COG0625	glutathione transferase activity
LI89_RS10700	COG0477	Major facilitator Superfamily
LI89_RS10705	COG4221	oxidoreductase activity
LI89_RS10710	COG1742	UPF0060 membrane protein
LI89_RS10740	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
LI89_RS10745	COG1940	carbohydrate kinase activity
LI89_RS10750	COG0583	DNA-binding transcription factor activity
LI89_RS10755	COG2814	Major facilitator Superfamily
LI89_RS10780	COG0114	fumarate hydratase activity
LI89_RS10790	COG5339	Protein conserved in bacteria
LI89_RS10800	COG1609	Transcriptional regulator
LI89_RS10805	COG1263	PTS System
LI89_RS10805	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LI89_RS10810	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
LI89_RS10815	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
LI89_RS10820	COG0385	Bile acid
LI89_RS10825	COG0673	inositol 2-dehydrogenase activity
LI89_RS10835	COG1172	Belongs to the binding-protein-dependent transport system permease family
LI89_RS10840	COG1129	ABC transporter
LI89_RS10845	COG1879	ABC-type sugar transport system periplasmic component
LI89_RS10855	COG2160	L-arabinose isomerase activity
LI89_RS10875	COG2759	Belongs to the formate--tetrahydrofolate ligase family
LI89_RS10885	COG4657	Part of a membrane complex involved in electron transport
LI89_RS10895	COG4656	Part of a membrane complex involved in electron transport
LI89_RS10900	COG2207	Transcriptional regulator
LI89_RS10900	COG3708	Transcriptional regulator
LI89_RS10905	COG4658	electron transport chain
LI89_RS10910	COG4659	FMN binding
LI89_RS10920	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
LI89_RS10935	COG0243	molybdopterin cofactor binding
LI89_RS10940	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
LI89_RS10945	COG1966	Carbon starvation protein
LI89_RS10950	COG2879	small protein
LI89_RS10955	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LI89_RS10960	COG1349	DNA-binding transcription factor activity
LI89_RS10970	COG0235	Class ii aldolase
LI89_RS10980	COG0023	Translation Initiation Factor
LI89_RS10985	COG0284	orotidine-5'-phosphate decarboxylase activity
LI89_RS10995	COG3135	benzoate transporter
LI89_RS11000	COG1396	sequence-specific DNA binding
LI89_RS11010	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
LI89_RS11015	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
LI89_RS11020	COG0671	phosphoesterase, PA-phosphatase related
LI89_RS11030	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
LI89_RS11045	COG4974	Belongs to the 'phage' integrase family
LI89_RS11100	COG0583	DNA-binding transcription factor activity
LI89_RS11115	COG0616	signal peptide processing
LI89_RS11120	COG1028	Short-chain dehydrogenase reductase Sdr
LI89_RS11125	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
LI89_RS11135	COG1187	pseudouridine synthase activity
LI89_RS11140	COG0009	L-threonylcarbamoyladenylate synthase
LI89_RS11145	COG0613	PHP domain protein
LI89_RS11155	COG0512	Glutamine amidotransferase of anthranilate synthase
LI89_RS11165	COG0135	phosphoribosylanthranilate isomerase activity
LI89_RS11165	COG0134	indole-3-glycerol-phosphate synthase activity
LI89_RS11170	COG0133	tryptophan synthase activity
LI89_RS11175	COG0159	tryptophan synthase activity
LI89_RS11185	COG3047	cAMP biosynthetic process
LI89_RS11190	COG0727	PFAM Uncharacterised protein family (UPF0153)
LI89_RS11205	COG2917	probably involved in intracellular septation
LI89_RS11215	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
LI89_RS11220	COG2350	Protein conserved in bacteria
LI89_RS11235	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LI89_RS11240	COG3099	Belongs to the UPF0263 family
LI89_RS11250	COG0444	Belongs to the ABC transporter superfamily
LI89_RS11255	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LI89_RS11275	COG2095	MarC family integral membrane protein
LI89_RS11280	COG1012	belongs to the aldehyde dehydrogenase family
LI89_RS11280	COG1454	alcohol dehydrogenase
LI89_RS11295	COG2916	Histone family protein nucleoid-structuring protein H-NS
LI89_RS11305	COG0745	RESPONSE REGULATOR receiver
LI89_RS11310	COG1752	Esterase of the alpha-beta hydrolase superfamily
LI89_RS11320	COG3012	SEC-C Motif Domain Protein
LI89_RS11325	COG0788	formyltetrahydrofolate deformylase activity
LI89_RS11355	COG0583	DNA-binding transcription factor activity
LI89_RS11360	COG0708	Exodeoxyribonuclease III
LI89_RS11365	COG0494	nUDIX hydrolase
LI89_RS11375	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LI89_RS11385	COG0778	Nitroreductase
LI89_RS11390	COG0616	signal peptide processing
LI89_RS11395	COG0252	asparaginase activity
LI89_RS11400	COG1335	isochorismatase
LI89_RS11405	COG3139	Protein of unknown function (DUF1315)
LI89_RS11410	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LI89_RS11425	COG3713	MltA-interacting MipA family protein
LI89_RS11430	COG2766	serine protein kinase
LI89_RS11435	COG2718	Belongs to the UPF0229 family
LI89_RS11450	COG0583	DNA-binding transcription factor activity
LI89_RS11460	COG2202	Pas domain
LI89_RS11460	COG2200	EAL domain
LI89_RS11460	COG2199	diguanylate cyclase activity
LI89_RS11465	COG2814	Major facilitator Superfamily
LI89_RS11470	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LI89_RS11475	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LI89_RS11480	COG2719	SpoVR family
LI89_RS11485	COG2186	Transcriptional regulator
LI89_RS11490	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
LI89_RS11495	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
LI89_RS11500	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LI89_RS11510	COG2983	Belongs to the UPF0260 family
LI89_RS11515	COG0179	Fumarylacetoacetate (FAA) hydrolase
LI89_RS11520	COG2951	lytic endotransglycosylase activity
LI89_RS11525	COG3100	YcgL domain-containing protein
LI89_RS11535	COG0850	regulation of cytokinetic process
LI89_RS11540	COG2894	cell division
LI89_RS11545	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
LI89_RS11550	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
LI89_RS11555	COG0318	PFAM AMP-dependent synthetase and ligase
LI89_RS11560	COG3065	identical protein binding
LI89_RS11570	COG1199	ATP-dependent helicase activity
LI89_RS11575	COG0251	oxidation-reduction process
LI89_RS11580	COG2076	Multidrug Resistance protein
LI89_RS11585	COG2076	Multidrug Resistance protein
LI89_RS11590	COG0800	Aldolase
LI89_RS11595	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
LI89_RS11600	COG1737	Transcriptional regulator
LI89_RS11605	COG0469	pyruvate kinase activity
LI89_RS11610	COG1560	Kdo2-lipid A biosynthetic process
LI89_RS11615	COG0739	heme binding
LI89_RS11620	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
LI89_RS11625	COG1121	(ABC) transporter
LI89_RS11630	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LI89_RS11635	COG3104	oligopeptide transport
LI89_RS11640	COG2255	four-way junction helicase activity
LI89_RS11645	COG0632	four-way junction helicase activity
LI89_RS11650	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
LI89_RS11655	COG0217	transcriptional regulatory protein
LI89_RS11660	COG0494	nUDIX hydrolase
LI89_RS11665	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
LI89_RS11670	COG1335	isochorismatase
LI89_RS11675	COG1801	Protein of unknown function DUF72
LI89_RS11680	COG3788	relative of glutathione S-transferase, MAPEG superfamily
LI89_RS11685	COG2226	methyltransferase
LI89_RS11690	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LI89_RS11695	COG3142	Participates in the control of copper homeostasis
LI89_RS11700	COG3102	Protein conserved in bacteria
LI89_RS11705	COG0018	arginyl-trna synthetase
LI89_RS11710	COG0728	peptidoglycan biosynthetic process
LI89_RS11715	COG0673	inositol 2-dehydrogenase activity
LI89_RS11725	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LI89_RS11750	COG0477	Major facilitator Superfamily
LI89_RS11760	COG3381	protein complex oligomerization
LI89_RS11765	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
LI89_RS11770	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LI89_RS11790	COG3706	GGDEF domain
LI89_RS11795	COG0659	secondary active sulfate transmembrane transporter activity
LI89_RS11800	COG2877	3-deoxy-8-phosphooctulonate synthase activity
LI89_RS11815	COG2890	protein-(glutamine-N5) methyltransferase activity
LI89_RS11820	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
LI89_RS11825	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
LI89_RS11830	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
LI89_RS11840	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LI89_RS11850	COG0193	aminoacyl-tRNA hydrolase activity
LI89_RS11860	COG0012	GTP binding
LI89_RS11865	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LI89_RS11875	COG4948	Mandelate Racemase Muconate Lactonizing
LI89_RS11880	COG0800	Aldolase
LI89_RS11885	COG3734	2-keto-3-deoxy-galactonokinase
LI89_RS11890	COG2186	Transcriptional regulator
LI89_RS11905	COG2979	Protein of unknown function (DUF533)
LI89_RS11910	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
LI89_RS11915	COG3772	lysozyme
LI89_RS11950	COG0488	(ABC) transporter
LI89_RS12005	COG2826	transposase and inactivated derivatives, IS30 family
LI89_RS12010	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
LI89_RS12010	COG2755	lipolytic protein G-D-S-L family
LI89_RS12090	COG0582	viral genome integration into host DNA
LI89_RS12100	COG1276	copper resistance
LI89_RS12105	COG2372	response to copper ion
LI89_RS12110	COG1528	Iron-storage protein
LI89_RS12125	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LI89_RS12130	COG1770	oligopeptidase
LI89_RS12140	COG3097	Belongs to the UPF0267 family
LI89_RS12145	COG3141	response to X-ray
LI89_RS12150	COG0513	Belongs to the DEAD box helicase family
LI89_RS12155	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
LI89_RS12160	COG3140	Belongs to the UPF0181 family
LI89_RS12170	COG0494	nUDIX hydrolase
LI89_RS12175	COG1760	l-serine dehydratase
LI89_RS12180	COG1253	flavin adenine dinucleotide binding
LI89_RS12185	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LI89_RS12185	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
LI89_RS12190	COG3715	PTS system
LI89_RS12195	COG3716	PTS system mannose fructose sorbose family IID component
LI89_RS12200	COG4811	Protein of unknown function (DUF986)
LI89_RS12205	COG1971	Probably functions as a manganese efflux pump
LI89_RS12215	COG5002	protein histidine kinase activity
LI89_RS12215	COG5001	Diguanylate cyclase
LI89_RS12215	COG3447	MASE1 domain protein
LI89_RS12225	COG2226	methyltransferase
LI89_RS12230	COG0768	penicillin binding
LI89_RS12235	COG1496	oxidoreductase activity
LI89_RS12255	COG1113	amino acid transport
LI89_RS12285	COG2207	Transcriptional regulator
LI89_RS12310	COG1132	(ABC) transporter
LI89_RS12330	COG5001	Diguanylate cyclase
LI89_RS12330	COG4251	negative regulation of phosphorylation
LI89_RS12330	COG3706	GGDEF domain
LI89_RS12330	COG2203	Gaf domain
LI89_RS12345	COG3755	Protein conserved in bacteria
LI89_RS12360	COG2271	Major facilitator Superfamily
LI89_RS12370	COG4948	Mandelate Racemase Muconate Lactonizing
LI89_RS12375	COG1802	Transcriptional regulator
LI89_RS12380	COG1063	alcohol dehydrogenase
LI89_RS12385	COG0246	Mannitol dehydrogenase
LI89_RS12390	COG2721	sulfolactate sulfo-lyase activity
LI89_RS12395	COG1126	abc transporter atp-binding protein
LI89_RS12400	COG0765	amino acid transport
LI89_RS12405	COG0765	amino acid transport
LI89_RS12425	COG1733	regulation of RNA biosynthetic process
LI89_RS12430	COG0702	epimerase
LI89_RS12435	COG2873	o-acetylhomoserine
LI89_RS12455	COG3772	lysozyme
LI89_RS12520	COG0538	isocitrate dehydrogenase activity
LI89_RS12525	COG1187	pseudouridine synthase activity
LI89_RS12535	COG0482	sulfurtransferase activity
LI89_RS12540	COG2915	High frequency lysogenization protein hflD homolog
LI89_RS12545	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
LI89_RS12555	COG0745	RESPONSE REGULATOR receiver
LI89_RS12565	COG2850	peptidyl-arginine hydroxylation
LI89_RS12580	COG1940	carbohydrate kinase activity
LI89_RS12590	COG4591	ABC-type transport system involved in lipoprotein release permease component
LI89_RS12600	COG4591	ABC-type transport system involved in lipoprotein release permease component
LI89_RS12605	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
LI89_RS12610	COG3134	Outer membrane lipoprotein
LI89_RS12615	COG1252	NADH dehydrogenase
LI89_RS12620	COG3150	esterase
LI89_RS12625	COG1472	Belongs to the glycosyl hydrolase 3 family
LI89_RS12635	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
LI89_RS12640	COG5633	Lipoprotein
LI89_RS12645	COG0537	adenosine 5'-monophosphoramidase activity
LI89_RS12650	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LI89_RS12660	COG1263	PTS System
LI89_RS12660	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LI89_RS12665	COG0084	hydrolase, TatD family'
LI89_RS12670	COG0470	DNA polymerase III
LI89_RS12675	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
LI89_RS12680	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
LI89_RS12685	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LI89_RS12690	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LI89_RS12700	COG1028	Short-chain dehydrogenase reductase Sdr
LI89_RS12705	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
LI89_RS12710	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LI89_RS12715	COG0416	fatty acid biosynthetic process
LI89_RS12720	COG0333	Belongs to the bacterial ribosomal protein bL32 family
LI89_RS12725	COG1399	metal-binding, possibly nucleic acid-binding protein
LI89_RS12730	COG0424	maF-like protein
LI89_RS12735	COG0564	pseudouridine synthase activity
LI89_RS12740	COG1530	ribonuclease E activity
LI89_RS12740	COG1530	ribonuclease E activity
LI89_RS12745	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
LI89_RS12750	COG0418	dihydroorotase activity
LI89_RS12775	COG0628	permease
LI89_RS12780	COG1054	Belongs to the UPF0176 family
LI89_RS12810	COG1560	Kdo2-lipid A biosynthetic process
LI89_RS12815	COG2259	Doxx family
LI89_RS12820	COG2814	Major facilitator Superfamily
LI89_RS12835	COG5645	(Lipo)protein
LI89_RS12840	COG2943	transferase activity, transferring hexosyl groups
LI89_RS12845	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
LI89_RS12860	COG3263	regulation of cellular component size
LI89_RS12870	COG3916	Acyl-homoserine-lactone synthase
LI89_RS12875	COG2771	luxR family
LI89_RS12880	COG4235	cytochrome complex assembly
LI89_RS12885	COG3088	subunit of a heme lyase
LI89_RS12895	COG1138	Cytochrome C-type biogenesis protein
LI89_RS12900	COG3301	Polysulphide reductase, NrfD
LI89_RS12905	COG0437	4 iron, 4 sulfur cluster binding
LI89_RS12910	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
LI89_RS12930	COG2920	part of a sulfur-relay system
LI89_RS12935	COG1254	Belongs to the acylphosphatase family
LI89_RS12950	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
LI89_RS12955	COG3785	DNA binding
LI89_RS12960	COG1832	CoA-binding protein
LI89_RS12970	COG1803	Methylglyoxal synthase
LI89_RS12975	COG0210	DNA helicase
LI89_RS12980	COG3304	Inner membrane component domain
LI89_RS12985	COG1289	transmembrane transporter activity
LI89_RS12990	COG3070	regulator of competence-specific genes
LI89_RS12995	COG5404	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
LI89_RS13005	COG3120	sequence-specific DNA binding
LI89_RS13010	COG1067	ATP-dependent peptidase activity
LI89_RS13015	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LI89_RS13025	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LI89_RS13030	COG3009	Protein conserved in bacteria
LI89_RS13035	COG3008	intermembrane lipid transfer
LI89_RS13035	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
LI89_RS13040	COG2995	paraquat-inducible protein a
LI89_RS13045	COG0488	(ABC) transporter
LI89_RS13050	COG0116	Belongs to the methyltransferase superfamily
LI89_RS13050	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
LI89_RS13055	COG3217	Mosc domain protein beta barrel domain protein
LI89_RS13055	COG0633	Ferredoxin
LI89_RS13065	COG0167	dihydroorotate dehydrogenase activity
LI89_RS13070	COG0308	aminopeptidase N
LI89_RS13075	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
LI89_RS13080	COG0017	Asparaginyl-tRNA synthetase
LI89_RS13090	COG1448	Aminotransferase
LI89_RS13095	COG2200	EAL domain
LI89_RS13100	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LI89_RS13105	COG3108	Peptidase M15
LI89_RS13110	COG2989	Protein conserved in bacteria
LI89_RS13115	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
LI89_RS13125	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
LI89_RS13130	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LI89_RS13135	COG1434	Gram-negative-bacterium-type cell wall biogenesis
LI89_RS13140	COG3173	Aminoglycoside phosphotransferase
LI89_RS13145	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
LI89_RS13150	COG2835	tetraacyldisaccharide 4'-kinase activity
LI89_RS13155	COG1278	Cold shock
LI89_RS13165	COG5383	Protein conserved in bacteria
LI89_RS13170	COG1663	tetraacyldisaccharide 4'-kinase activity
LI89_RS13180	COG0658	competence protein
LI89_RS13180	COG2333	competence protein COMEC
LI89_RS13185	COG0776	regulation of translation
LI89_RS13190	COG0539	negative regulation of cytoplasmic translation
LI89_RS13195	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
LI89_RS13200	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
LI89_RS13205	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
LI89_RS13210	COG2323	membrane
LI89_RS13215	COG0252	asparaginase activity
LI89_RS13220	COG1944	ATP diphosphatase activity
LI89_RS13225	COG2116	formate transmembrane transporter activity
LI89_RS13230	COG1882	Formate acetyltransferase
LI89_RS13235	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
LI89_RS13240	COG2814	Major facilitator Superfamily
LI89_RS13245	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
LI89_RS13250	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LI89_RS13255	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
LI89_RS13260	COG1674	ftsk spoiiie
LI89_RS13260	COG3107	peptidoglycan biosynthetic process
LI89_RS13265	COG1522	sequence-specific DNA binding
LI89_RS13270	COG0492	ferredoxin-NADP+ reductase activity
LI89_RS13280	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
LI89_RS13285	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
LI89_RS13290	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
LI89_RS13295	COG0542	response to heat
LI89_RS13300	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
LI89_RS13305	COG1278	Cold shock
LI89_RS13315	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LI89_RS13320	COG2990	Protein conserved in bacteria
LI89_RS13325	COG3593	DNA synthesis involved in DNA repair
LI89_RS13330	COG2431	L-lysine efflux transmembrane transporter activity
LI89_RS13335	COG1151	hydroxylamine reductase activity
LI89_RS13340	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LI89_RS13345	COG0028	Belongs to the TPP enzyme family
LI89_RS13355	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
LI89_RS13360	COG0702	epimerase
LI89_RS13365	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LI89_RS13375	COG1126	abc transporter atp-binding protein
LI89_RS13380	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LI89_RS13385	COG4215	(ABC) transporter
LI89_RS13390	COG4160	amino acid transport
LI89_RS13400	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LI89_RS13405	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LI89_RS13415	COG1177	transmembrane transport
LI89_RS13420	COG1176	ABC-type spermidine putrescine transport system, permease component I
LI89_RS13425	COG3842	ATPase activity
LI89_RS13430	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
LI89_RS13450	COG2985	domain, Protein
LI89_RS13450	COG0569	domain protein
LI89_RS13460	COG0671	phosphoesterase, PA-phosphatase related
LI89_RS13465	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
LI89_RS13470	COG1349	DNA-binding transcription factor activity
LI89_RS13475	COG0814	amino acid
LI89_RS13480	COG1760	l-serine dehydratase
LI89_RS13485	COG1686	Belongs to the peptidase S11 family
LI89_RS13495	COG0626	cystathionine gamma-synthase activity
LI89_RS13510	COG2011	ABC-type metal ion transport system permease component
LI89_RS13535	COG0625	glutathione transferase activity
LI89_RS13540	COG4771	TonB-dependent receptor
LI89_RS13550	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LI89_RS13555	COG0833	amino acid
LI89_RS13560	COG0583	DNA-binding transcription factor activity
LI89_RS13570	COG2855	membrane
LI89_RS13575	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
LI89_RS13600	COG3710	Transcriptional regulator
LI89_RS13605	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LI89_RS13605	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LI89_RS13605	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
LI89_RS13610	COG1105	Belongs to the carbohydrate kinase PfkB family
LI89_RS13625	COG3005	denitrification pathway
LI89_RS13630	COG0243	molybdopterin cofactor binding
LI89_RS13645	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LI89_RS13650	COG1312	Catalyzes the dehydration of D-mannonate
LI89_RS13660	COG0246	Mannitol dehydrogenase
LI89_RS13665	COG2186	Transcriptional regulator
LI89_RS13675	COG0523	cobalamin synthesis protein
LI89_RS13680	COG0671	phosphoesterase, PA-phosphatase related
LI89_RS13685	COG0791	NLP P60 protein
LI89_RS13695	COG2200	EAL domain
LI89_RS13700	COG4166	transmembrane transport
LI89_RS13705	COG4174	ABC transporter (Permease)
LI89_RS13710	COG4239	(ABC) transporter, permease
LI89_RS13715	COG4172	Belongs to the ABC transporter superfamily
LI89_RS13725	COG2814	Major facilitator Superfamily
LI89_RS13730	COG1187	pseudouridine synthase activity
LI89_RS13735	COG1061	Type III restriction enzyme res subunit
LI89_RS13745	COG3081	Nucleoid-associated protein
LI89_RS13750	COG3082	Protein of unknown function (DUF1414)
LI89_RS13775	COG2723	6-phospho-beta-galactosidase activity
LI89_RS13780	COG2190	(PTS) system
LI89_RS13780	COG1263	PTS System
LI89_RS13780	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LI89_RS13785	COG1737	Transcriptional regulator
LI89_RS13830	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LI89_RS13845	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
LI89_RS13855	COG1132	(ABC) transporter
LI89_RS13870	COG2223	nitrite transmembrane transporter activity
LI89_RS13875	COG0642	Histidine kinase
LI89_RS13875	COG2198	Histidine kinase
LI89_RS13885	COG2205	protein histidine kinase activity
LI89_RS13885	COG0784	Response regulator, receiver
LI89_RS13895	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LI89_RS13900	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LI89_RS13910	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LI89_RS13915	COG4574	serine-type endopeptidase inhibitor activity
LI89_RS13935	COG0814	amino acid
LI89_RS13955	COG1441	menaquinone biosynthetic process
LI89_RS13960	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
LI89_RS13965	COG0596	Alpha beta hydrolase
LI89_RS13970	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
LI89_RS13975	COG1169	isochorismate synthase
LI89_RS13980	COG4575	ribosome binding
LI89_RS13985	COG0129	dihydroxy-acid dehydratase activity
LI89_RS13990	COG4702	Belongs to the UPF0303 family
LI89_RS14000	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LI89_RS14005	COG1609	Transcriptional regulator
LI89_RS14010	COG1028	Short-chain dehydrogenase reductase Sdr
LI89_RS14015	COG3265	gluconokinase activity
LI89_RS14045	COG1007	ATP synthesis coupled electron transport
LI89_RS14050	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LI89_RS14055	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LI89_RS14060	COG0713	ATP synthesis coupled electron transport
LI89_RS14065	COG0839	Belongs to the complex I subunit 6 family
LI89_RS14070	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LI89_RS14075	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
LI89_RS14080	COG1034	ATP synthesis coupled electron transport
LI89_RS14095	COG0649	NAD binding
LI89_RS14095	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LI89_RS14100	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LI89_RS14105	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LI89_RS14110	COG0583	DNA-binding transcription factor activity
LI89_RS14115	COG0436	Aminotransferase
LI89_RS14125	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
LI89_RS14130	COG0471	metal ion transport
LI89_RS14130	COG0490	domain, Protein
LI89_RS14140	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LI89_RS14145	COG3013	Belongs to the UPF0304 family
LI89_RS14150	COG3092	negative regulation of chromosome organization
LI89_RS14160	COG0857	belongs to the CobB CobQ family
LI89_RS14160	COG0280	phosphate acetyltransferase
LI89_RS14165	COG1609	Transcriptional regulator
LI89_RS14170	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LI89_RS14180	COG3037	sugar-specific permease SgaT UlaA
LI89_RS14185	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
LI89_RS14190	COG0622	Phosphoesterase
LI89_RS14200	COG1090	epimerase
LI89_RS14205	COG4598	ABC transporter
LI89_RS14210	COG4160	amino acid transport
LI89_RS14215	COG4215	(ABC) transporter
LI89_RS14220	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LI89_RS14225	COG0163	prenyltransferase activity
LI89_RS14230	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
LI89_RS14235	COG1286	toxin biosynthetic process
LI89_RS14240	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
LI89_RS14245	COG0285	dihydrofolate synthase activity
LI89_RS14250	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
LI89_RS14255	COG0586	Pfam SNARE associated Golgi protein
LI89_RS14265	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LI89_RS14270	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LI89_RS14280	COG0697	spore germination
LI89_RS14285	COG0697	spore germination
LI89_RS14290	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LI89_RS14295	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LI89_RS14320	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
LI89_RS14330	COG1609	Transcriptional regulator
LI89_RS14340	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LI89_RS14345	COG2723	6-phospho-beta-galactosidase activity
LI89_RS14350	COG1447	Phosphotransferase system cellobiose-specific component IIA
LI89_RS14360	COG1794	racemase activity, acting on amino acids and derivatives
LI89_RS14370	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LI89_RS14375	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
LI89_RS14375	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LI89_RS14385	COG3101	peptidyl-lysine hydroxylation
LI89_RS14390	COG0730	response to heat
LI89_RS14395	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
LI89_RS14400	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
LI89_RS14405	COG2890	protein-(glutamine-N5) methyltransferase activity
LI89_RS14410	COG2840	Smr protein MutS2
LI89_RS14415	COG2062	phosphohistidine phosphatase, SixA
LI89_RS14420	COG1024	Enoyl-CoA hydratase
LI89_RS14420	COG1250	3-hydroxyacyl-CoA dehydrogenase
LI89_RS14425	COG0183	Belongs to the thiolase family
LI89_RS14430	COG3691	Protein conserved in bacteria
LI89_RS14455	COG3088	subunit of a heme lyase
LI89_RS14455	COG4235	cytochrome complex assembly
LI89_RS14465	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LI89_RS14470	COG1138	Cytochrome C-type biogenesis protein
LI89_RS14475	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
LI89_RS14480	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LI89_RS14485	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LI89_RS14490	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LI89_RS14500	COG2116	formate transmembrane transporter activity
LI89_RS14540	COG4977	sequence-specific DNA binding
LI89_RS14560	COG3188	usher protein
LI89_RS14570	COG3121	Chaperone
LI89_RS14580	COG3121	Chaperone
LI89_RS14590	COG2831	hemolysin activation secretion protein
LI89_RS14595	COG3210	domain, Protein
LI89_RS14605	COG3210	domain, Protein
LI89_RS14660	COG3210	domain, Protein
LI89_RS14685	COG2824	Alkylphosphonate utilization operon protein PhnA
LI89_RS14690	COG1695	Transcriptional regulator
LI89_RS14700	COG2723	6-phospho-beta-galactosidase activity
LI89_RS14705	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LI89_RS14705	COG1263	PTS System
LI89_RS14710	COG1609	Transcriptional regulator
LI89_RS14715	COG2353	YceI-like domain
LI89_RS14720	COG3038	cytochrome b561
LI89_RS14725	COG0657	acetylesterase activity
LI89_RS14725	COG2755	lipolytic protein G-D-S-L family
LI89_RS14745	COG1127	ABC transporter
LI89_RS14750	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LI89_RS14770	COG0531	amino acid
LI89_RS14775	COG2951	lytic endotransglycosylase activity
LI89_RS14795	COG1280	lysine exporter protein (LysE YggA)
LI89_RS14805	COG2723	6-phospho-beta-galactosidase activity
LI89_RS14820	COG1598	PFAM Uncharacterised protein family UPF0150
LI89_RS14825	COG3038	cytochrome b561
LI89_RS14830	COG0436	Aminotransferase
LI89_RS14845	COG3275	phosphorelay sensor kinase activity
LI89_RS14850	COG3279	Response regulator of the LytR AlgR family
LI89_RS14855	COG2223	nitrite transmembrane transporter activity
LI89_RS14860	COG0837	glucose binding
LI89_RS14875	COG3961	Belongs to the TPP enzyme family
LI89_RS14880	COG0667	Aldo Keto reductase
LI89_RS14890	COG1914	H( )-stimulated, divalent metal cation uptake system
LI89_RS14895	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LI89_RS14930	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LI89_RS14960	COG3530	Putative quorum-sensing-regulated virulence factor
LI89_RS14965	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LI89_RS14985	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LI89_RS14990	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LI89_RS15000	COG2205	protein histidine kinase activity
LI89_RS15005	COG0745	RESPONSE REGULATOR receiver
LI89_RS15010	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LI89_RS15030	COG4208	sulfate ABC transporter
LI89_RS15035	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
LI89_RS15040	COG4150	thiosulfate binding
LI89_RS15050	COG1737	Transcriptional regulator
LI89_RS15055	COG2731	YhcH YjgK YiaL family protein
LI89_RS15070	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LI89_RS15075	COG2837	iron assimilation
LI89_RS15085	COG3111	PFAM Bacterial OB fold (BOF) protein
LI89_RS15095	COG0456	acetyltransferase
LI89_RS15100	COG0408	coproporphyrinogen oxidase activity
LI89_RS15105	COG1671	Belongs to the UPF0178 family
LI89_RS15125	COG0494	nUDIX hydrolase
LI89_RS15130	COG3005	denitrification pathway
LI89_RS15135	COG3043	anaerobic respiration
LI89_RS15140	COG0243	molybdopterin cofactor binding
LI89_RS15145	COG3062	negative regulation of establishment of protein localization
LI89_RS15155	COG2197	response regulator
LI89_RS15165	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LI89_RS15345	COG1393	Belongs to the ArsC family
LI89_RS15350	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LI89_RS15355	COG1876	peptidase activity
LI89_RS15365	COG0400	carboxylic ester hydrolase activity
LI89_RS15370	COG1444	tRNA N-acetyltransferase activity
LI89_RS15375	COG2707	UPF0756 membrane protein
LI89_RS15380	COG2321	neutral zinc metallopeptidase
LI89_RS15385	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
LI89_RS15390	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
LI89_RS15395	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LI89_RS15400	COG2716	regulation of RNA biosynthetic process
LI89_RS15405	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
LI89_RS15410	COG0628	permease
LI89_RS15415	COG4783	chaperone-mediated protein folding
LI89_RS15420	COG1393	Belongs to the ArsC family
LI89_RS15425	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LI89_RS15430	COG2233	PERMEase
LI89_RS15435	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
LI89_RS15440	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
LI89_RS15445	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
LI89_RS15450	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LI89_RS15470	COG0581	inorganic phosphate transmembrane transporter activity
LI89_RS15475	COG0573	inorganic phosphate transmembrane transporter activity
LI89_RS15480	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
LI89_RS15495	COG2239	Acts as a magnesium transporter
LI89_RS15500	COG5002	protein histidine kinase activity
LI89_RS15500	COG5001	Diguanylate cyclase
LI89_RS15500	COG3447	MASE1 domain protein
LI89_RS15505	COG0443	Heat shock 70 kDa protein
LI89_RS15510	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LI89_RS15520	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LI89_RS15530	COG0477	Major facilitator Superfamily
LI89_RS15535	COG2205	protein histidine kinase activity
LI89_RS15540	COG0745	RESPONSE REGULATOR receiver
LI89_RS15545	COG3422	double-strand break repair
LI89_RS15560	COG0826	peptidase U32
LI89_RS15565	COG1597	lipid kinase activity
LI89_RS15570	COG3730	PTS system glucitol sorbitol-specific
LI89_RS15585	COG1028	Short-chain dehydrogenase reductase Sdr
LI89_RS15590	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
LI89_RS15595	COG1349	DNA-binding transcription factor activity
LI89_RS15615	COG0351	phosphomethylpyrimidine kinase
LI89_RS15650	COG0519	Catalyzes the synthesis of GMP from XMP
LI89_RS15650	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LI89_RS15655	COG0517	IMP dehydrogenase activity
LI89_RS15655	COG0516	GMP reductase activity
LI89_RS15660	COG1570	exodeoxyribonuclease VII activity
LI89_RS15665	COG1645	bacterial-type flagellum-dependent swarming motility
LI89_RS15675	COG1160	GTP binding
LI89_RS15685	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LI89_RS15690	COG2976	Protein conserved in bacteria
LI89_RS15695	COG0124	histidyl-tRNA synthetase
LI89_RS15700	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
LI89_RS15705	COG1426	Protein conserved in bacteria
LI89_RS15715	COG0820	rRNA (adenine-C2-)-methyltransferase activity
LI89_RS15720	COG0105	UTP biosynthetic process
LI89_RS15730	COG4953	penicillin-binding protein 1C
LI89_RS15735	COG2373	Large extracellular alpha-helical protein
LI89_RS15740	COG3468	outer membrane autotransporter barrel domain protein
LI89_RS15745	COG3468	outer membrane autotransporter barrel domain protein
LI89_RS15760	COG2975	iron-sulfur cluster assembly
LI89_RS15765	COG0633	Ferredoxin
LI89_RS15770	COG0443	Heat shock 70 kDa protein
LI89_RS15775	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
LI89_RS15780	COG0316	Belongs to the HesB IscA family
LI89_RS15785	COG0822	iron-sulfur transferase activity
LI89_RS15795	COG1959	2 iron, 2 sulfur cluster binding
LI89_RS15800	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
LI89_RS15810	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
LI89_RS15815	COG3683	transport system, periplasmic component
LI89_RS15820	COG3711	transcriptional antiterminator
LI89_RS15825	COG2814	Major facilitator Superfamily
LI89_RS15830	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LI89_RS15835	COG1017	nitric oxide dioxygenase activity
LI89_RS15835	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LI89_RS15840	COG2188	Transcriptional regulator
LI89_RS15850	COG3457	Alanine racemase
LI89_RS15855	COG1735	metal-dependent hydrolase with the TIM-barrel fold
LI89_RS15870	COG0347	Belongs to the P(II) protein family
LI89_RS15875	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
LI89_RS15875	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LI89_RS15880	COG2204	response regulator
LI89_RS15885	COG3170	Tfp pilus assembly protein FimV
LI89_RS15890	COG2205	protein histidine kinase activity
LI89_RS15905	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
LI89_RS15920	COG0560	Phosphoserine phosphatase
LI89_RS15930	COG1737	Transcriptional regulator
LI89_RS15935	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
LI89_RS15940	COG2610	gluconate transmembrane transporter activity
LI89_RS15950	COG0736	holo-[acyl-carrier-protein] synthase activity
LI89_RS15955	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
LI89_RS15960	COG1381	Involved in DNA repair and RecF pathway recombination
LI89_RS15965	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
LI89_RS15970	COG0571	ribonuclease III activity
LI89_RS15980	COG0481	GTPase activity
LI89_RS15990	COG3086	response to oxidative stress
LI89_RS16000	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
LI89_RS16010	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
LI89_RS16015	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
LI89_RS16020	COG0513	Belongs to the DEAD box helicase family
LI89_RS16035	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
LI89_RS16040	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
LI89_RS16045	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
LI89_RS16050	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
LI89_RS16055	COG0497	DNA recombination
LI89_RS16060	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LI89_RS16070	COG2867	negative regulation of translational initiation
LI89_RS16075	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
LI89_RS16085	COG0582	viral genome integration into host DNA
LI89_RS16150	COG2826	transposase and inactivated derivatives, IS30 family
LI89_RS16160	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
LI89_RS16180	COG1902	pentaerythritol trinitrate reductase activity
LI89_RS16200	COG1063	alcohol dehydrogenase
LI89_RS16205	COG3547	Transposase (IS116 IS110 IS902 family)
LI89_RS16225	COG2826	transposase and inactivated derivatives, IS30 family
LI89_RS16270	COG0659	secondary active sulfate transmembrane transporter activity
LI89_RS16275	COG3394	polysaccharide catabolic process
LI89_RS16280	COG2169	Transcriptional regulator
LI89_RS16280	COG1917	Cupin 2, conserved barrel domain protein
LI89_RS16285	COG1447	Phosphotransferase system cellobiose-specific component IIA
LI89_RS16290	COG2723	6-phospho-beta-galactosidase activity
LI89_RS16295	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LI89_RS16300	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LI89_RS16305	COG2133	pyrroloquinoline quinone binding
LI89_RS16320	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LI89_RS16330	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
LI89_RS16335	COG4413	Urea transporter
LI89_RS16340	COG0829	nickel cation binding
LI89_RS16345	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
LI89_RS16350	COG0830	nickel cation binding
LI89_RS16355	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
LI89_RS16360	COG0804	urea catabolic process
LI89_RS16370	COG0831	urea catabolic process
LI89_RS16385	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
LI89_RS16390	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LI89_RS16425	COG1278	Cold shock
LI89_RS16450	COG2207	Transcriptional regulator
LI89_RS16465	COG4575	ribosome binding
LI89_RS16475	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LI89_RS16480	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
LI89_RS16485	COG1780	Probably involved in ribonucleotide reductase function
LI89_RS16495	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LI89_RS16500	COG4175	Glycine betaine
LI89_RS16505	COG4176	ABC-type proline glycine betaine transport system permease component
LI89_RS16510	COG2113	Glycine betaine
LI89_RS16525	COG0328	RNA-DNA hybrid ribonuclease activity
LI89_RS16530	COG2226	methyltransferase
LI89_RS16535	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LI89_RS16540	COG1388	LysM domain
LI89_RS16540	COG0741	lytic transglycosylase activity
LI89_RS16545	COG3021	interspecies interaction between organisms
LI89_RS16550	COG2814	Major facilitator Superfamily
LI89_RS16555	COG0583	DNA-binding transcription factor activity
LI89_RS16560	COG0656	L-ascorbic acid biosynthetic process
LI89_RS16570	COG1028	Short-chain dehydrogenase reductase Sdr
LI89_RS16610	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LI89_RS16625	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LI89_RS16680	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
LI89_RS16690	COG2011	ABC-type metal ion transport system permease component
LI89_RS16695	COG1464	Belongs to the NlpA lipoprotein family
LI89_RS16705	COG1720	tRNA m6t6A37 methyltransferase activity
LI89_RS16710	COG0442	prolyl-tRNA aminoacylation
LI89_RS16715	COG3015	lipoprotein NlpE involved in copper resistance
LI89_RS16725	COG4681	YaeQ
LI89_RS16735	COG4568	rho-dependent transcription termination
LI89_RS16750	COG0346	lactoylglutathione lyase activity
LI89_RS16755	COG1982	Orn Lys Arg decarboxylase major
LI89_RS16760	COG0825	malonyl-CoA metabolic process
LI89_RS16765	COG0587	DNA-directed DNA polymerase activity
LI89_RS16770	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LI89_RS16780	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LI89_RS16785	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LI89_RS16790	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LI89_RS16795	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
LI89_RS16805	COG0750	zinc metalloprotease
LI89_RS16810	COG0575	Belongs to the CDS family
LI89_RS16820	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
LI89_RS16825	COG0233	cytoplasmic translational termination
LI89_RS16830	COG0528	UMP kinase activity
LI89_RS16835	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
LI89_RS16840	COG0052	Belongs to the universal ribosomal protein uS2 family
LI89_RS16855	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
LI89_RS16860	COG2171	N-acyltransferase activity
LI89_RS16875	COG0564	pseudouridine synthase activity
LI89_RS16880	COG3098	single-species biofilm formation
LI89_RS16890	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
LI89_RS16890	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
LI89_RS16895	COG1611	Belongs to the LOG family
LI89_RS16900	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LI89_RS16905	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
LI89_RS16910	COG2363	Small membrane protein
LI89_RS16915	COG0583	DNA-binding transcription factor activity
LI89_RS16925	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LI89_RS16930	COG2166	iron-sulfur cluster assembly
LI89_RS16935	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
LI89_RS16940	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
LI89_RS16960	COG0860	N-Acetylmuramoyl-L-alanine amidase
LI89_RS16965	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
LI89_RS16965	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LI89_RS16970	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LI89_RS16975	COG1074	ATP-dependent DNA helicase activity
LI89_RS16980	COG1025	Belongs to the peptidase M16 family
LI89_RS16985	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
LI89_RS17005	COG2165	general secretion pathway protein
LI89_RS17010	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
LI89_RS17015	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
LI89_RS17025	COG1051	belongs to the nudix hydrolase family
LI89_RS17035	COG3066	DNA modification
LI89_RS17040	COG0861	Integral membrane protein TerC family
LI89_RS17045	COG0667	Aldo Keto reductase
LI89_RS17050	COG0477	Major facilitator Superfamily
LI89_RS17055	COG0318	PFAM AMP-dependent synthetase and ligase
LI89_RS17055	COG0204	Acyl-transferase
LI89_RS17065	COG1609	Transcriptional regulator
LI89_RS17075	COG0583	DNA-binding transcription factor activity
LI89_RS17080	COG2814	Major facilitator Superfamily
LI89_RS17100	COG0840	transmembrane signaling receptor activity
LI89_RS17120	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
LI89_RS17150	COG2165	general secretion pathway protein
LI89_RS17160	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LI89_RS17180	COG0288	reversible hydration of carbon dioxide
LI89_RS17185	COG1733	regulation of RNA biosynthetic process
LI89_RS17190	COG1028	Short-chain dehydrogenase reductase Sdr
LI89_RS17200	COG0484	heat shock protein binding
LI89_RS17210	COG2271	Major facilitator Superfamily
LI89_RS17225	COG1522	sequence-specific DNA binding
LI89_RS17230	COG3706	GGDEF domain
LI89_RS17235	COG4319	ketosteroid isomerase
LI89_RS17240	COG1393	Belongs to the ArsC family
LI89_RS17245	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
LI89_RS17380	COG0582	viral genome integration into host DNA
LI89_RS17390	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
LI89_RS17395	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
LI89_RS17400	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
LI89_RS17405	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LI89_RS17410	COG4974	Belongs to the 'phage' integrase family
LI89_RS17415	COG0716	FMN binding
LI89_RS17420	COG4452	Inner membrane protein CreD
LI89_RS17425	COG2205	protein histidine kinase activity
LI89_RS17430	COG0745	RESPONSE REGULATOR receiver
LI89_RS17445	COG0354	folic acid binding
LI89_RS17450	COG1272	protein, Hemolysin III
LI89_RS17460	COG1028	Short-chain dehydrogenase reductase Sdr
LI89_RS17470	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LI89_RS17470	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LI89_RS17475	COG0509	glycine decarboxylation via glycine cleavage system
LI89_RS17480	COG0404	The glycine cleavage system catalyzes the degradation of glycine
LI89_RS17485	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LI89_RS17490	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LI89_RS17495	COG0006	proline dipeptidase activity
LI89_RS17500	COG3079	Belongs to the UPF0149 family
LI89_RS17505	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
LI89_RS17515	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LI89_RS17520	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LI89_RS17525	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
LI89_RS17530	COG0583	DNA-binding transcription factor activity
LI89_RS17540	COG1279	arginine transmembrane transporter activity
LI89_RS17550	COG0191	fructose-bisphosphate aldolase activity
LI89_RS17555	COG0126	phosphoglycerate kinase activity
LI89_RS17560	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LI89_RS17565	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
LI89_RS17570	COG0501	Belongs to the peptidase M48B family
LI89_RS17580	COG1166	arginine decarboxylase activity
LI89_RS17585	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
LI89_RS17605	COG3091	SprT-like family
LI89_RS17610	COG2356	endonuclease I
LI89_RS17615	COG1385	rRNA (uridine-N3-)-methyltransferase activity
LI89_RS17620	COG0189	ligase activity
LI89_RS17625	COG1678	Uncharacterized ACR, COG1678
LI89_RS17630	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
LI89_RS17635	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LI89_RS17645	COG2805	Type II/IV secretion system protein
LI89_RS17650	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
LI89_RS17655	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
LI89_RS17660	COG0762	integral membrane protein
LI89_RS17665	COG1872	DUF167
LI89_RS17670	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
LI89_RS17675	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LI89_RS17690	COG3171	Protein conserved in bacteria
LI89_RS17695	COG0220	tRNA (guanine-N7-)-methyltransferase activity
LI89_RS17700	COG1194	a g-specific adenine glycosylase
LI89_RS17705	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
LI89_RS17710	COG0741	lytic transglycosylase activity
LI89_RS17720	COG1982	Orn Lys Arg decarboxylase major
LI89_RS17735	COG0745	RESPONSE REGULATOR receiver
LI89_RS17745	COG2205	protein histidine kinase activity
LI89_RS17750	COG2197	response regulator
LI89_RS17770	COG0531	amino acid
LI89_RS17775	COG1982	Orn Lys Arg decarboxylase major
LI89_RS17785	COG1289	transmembrane transporter activity
LI89_RS17810	COG0024	Methionine aminopeptidase
LI89_RS17815	COG4604	ABC transporter, ATP-binding protein
LI89_RS17820	COG4605	iron ion homeostasis
LI89_RS17830	COG4607	ABC-type enterochelin transport system periplasmic component
LI89_RS17845	COG0697	spore germination
LI89_RS17850	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LI89_RS17860	COG0477	Major facilitator Superfamily
LI89_RS17865	COG1609	Transcriptional regulator
LI89_RS17875	COG1283	sodium-dependent phosphate transmembrane transporter activity
LI89_RS17890	COG0477	Major facilitator Superfamily
LI89_RS17900	COG2197	response regulator
LI89_RS17915	COG5001	Diguanylate cyclase
LI89_RS17930	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
LI89_RS17935	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
LI89_RS17940	COG0309	Hydrogenase expression formation protein (HypE)
LI89_RS17945	COG0409	Hydrogenase expression formation protein
LI89_RS17950	COG0298	carbon dioxide binding
LI89_RS17955	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
LI89_RS17965	COG1773	rubredoxin
LI89_RS17970	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
LI89_RS17975	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
LI89_RS17980	COG5557	Pfam Polysulphide reductase, NrfD
LI89_RS17985	COG0437	4 iron, 4 sulfur cluster binding
LI89_RS17990	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
LI89_RS17995	COG3133	Outer membrane lipoprotein
LI89_RS18015	COG0840	transmembrane signaling receptor activity
LI89_RS18020	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LI89_RS18025	COG2271	Major facilitator Superfamily
LI89_RS18030	COG4592	Periplasmic binding protein
LI89_RS18035	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LI89_RS18040	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LI89_RS18045	COG1120	ATPase activity
LI89_RS18055	COG4774	siderophore transport
LI89_RS18075	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LI89_RS18080	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LI89_RS18110	COG4964	Belongs to the GSP D family
LI89_RS18160	COG0848	biopolymer transport protein
LI89_RS18175	COG0586	Pfam SNARE associated Golgi protein
LI89_RS18180	COG2207	Transcriptional regulator
LI89_RS18185	COG1979	alcohol dehydrogenase
LI89_RS18190	COG0656	L-ascorbic acid biosynthetic process
LI89_RS18205	COG2132	Multicopper oxidase
LI89_RS18215	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
LI89_RS18220	COG2249	NAD(P)H dehydrogenase (quinone) activity
LI89_RS18225	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
LI89_RS18240	COG3150	esterase
LI89_RS18245	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
LI89_RS18250	COG3151	Protein conserved in bacteria
LI89_RS18255	COG0494	nUDIX hydrolase
LI89_RS18260	COG1538	Outer membrane efflux protein
LI89_RS18265	COG5463	Belongs to the UPF0441 family
LI89_RS18270	COG0754	glutathionylspermidine amidase activity
LI89_RS18275	COG3384	dioxygenase
LI89_RS18280	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LI89_RS18290	COG0531	amino acid
LI89_RS18295	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
LI89_RS18295	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
LI89_RS18300	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
LI89_RS18305	COG3025	triphosphatase activity
LI89_RS18310	COG4991	sh3 domain protein
LI89_RS18315	COG0617	tRNA 3'-terminal CCA addition
LI89_RS18320	COG1968	undecaprenyl-diphosphatase activity
LI89_RS18325	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
LI89_RS18330	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
LI89_RS18335	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
LI89_RS18340	COG0828	Belongs to the bacterial ribosomal protein bS21 family
LI89_RS18345	COG0358	DNA primase activity
LI89_RS18375	COG2003	Belongs to the UPF0758 family
LI89_RS18400	COG2378	regulation of single-species biofilm formation
LI89_RS18410	COG3596	GTP binding
LI89_RS18420	COG3039	Transposase
LI89_RS18425	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LI89_RS18430	COG0501	Belongs to the peptidase M48B family
LI89_RS18475	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LI89_RS18485	COG0542	response to heat
LI89_RS18490	COG0071	Belongs to the small heat shock protein (HSP20) family
LI89_RS18535	COG4983	Phage plasmid primase, P4 family domain protein
LI89_RS18560	COG3876	Protein conserved in bacteria
LI89_RS18570	COG1472	Belongs to the glycosyl hydrolase 3 family
LI89_RS18580	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
LI89_RS18585	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LI89_RS18585	COG1263	PTS System
LI89_RS18595	COG0531	amino acid
LI89_RS18600	COG0076	glutamate decarboxylase activity
LI89_RS18610	COG2814	Major facilitator Superfamily
LI89_RS18615	COG3247	response to pH
LI89_RS18625	COG0446	pyridine nucleotide-disulphide oxidoreductase
LI89_RS18625	COG1902	pentaerythritol trinitrate reductase activity
LI89_RS18630	COG2813	Specifically methylates the guanine in position
LI89_RS18640	COG1451	nucleotide metabolic process
LI89_RS18645	COG0673	inositol 2-dehydrogenase activity
LI89_RS18650	COG0861	Integral membrane protein TerC family
LI89_RS18655	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
LI89_RS18665	COG2721	sulfolactate sulfo-lyase activity
LI89_RS18670	COG0246	Mannitol dehydrogenase
LI89_RS18675	COG1904	glucuronate isomerase
LI89_RS18680	COG2271	Major facilitator Superfamily
LI89_RS18695	COG0586	Pfam SNARE associated Golgi protein
LI89_RS18710	COG4575	ribosome binding
LI89_RS18715	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
LI89_RS18725	COG2259	Doxx family
LI89_RS18730	COG0435	Glutathione S-transferase
LI89_RS18735	COG0583	DNA-binding transcription factor activity
LI89_RS18740	COG1741	Belongs to the pirin family
LI89_RS18745	COG1064	alcohol dehydrogenase
LI89_RS18750	COG0667	Aldo Keto reductase
LI89_RS18815	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
LI89_RS18825	COG0792	nuclease activity
LI89_RS18830	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
LI89_RS18835	COG2823	Periplasmic or secreted lipoprotein
LI89_RS18840	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LI89_RS18845	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
LI89_RS18850	COG0784	Response regulator, receiver
LI89_RS18850	COG2198	Histidine kinase
LI89_RS18850	COG5002	protein histidine kinase activity
LI89_RS18855	COG1242	4 iron, 4 sulfur cluster binding
LI89_RS18860	COG0070	glutamate synthase
LI89_RS18860	COG0067	glutamate synthase
LI89_RS18860	COG0069	glutamate synthase activity
LI89_RS18865	COG0493	'glutamate synthase
LI89_RS18875	COG2969	positive regulation of protein catabolic process
LI89_RS18880	COG0625	glutathione transferase activity
LI89_RS18885	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
LI89_RS18890	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
LI89_RS18895	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
LI89_RS18900	COG3105	Protein conserved in bacteria
LI89_RS18905	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LI89_RS18910	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LI89_RS18915	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LI89_RS18920	COG5007	Belongs to the BolA IbaG family
LI89_RS18925	COG3113	response to antibiotic
LI89_RS18930	COG2854	intermembrane phospholipid transfer
LI89_RS18935	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
LI89_RS18940	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LI89_RS18945	COG1127	ABC transporter
LI89_RS18950	COG0530	calcium, potassium:sodium antiporter activity
LI89_RS18955	COG0517	IMP dehydrogenase activity
LI89_RS18955	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
LI89_RS18960	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
LI89_RS18965	COG3117	lipopolysaccharide transmembrane transporter activity
LI89_RS18970	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
LI89_RS18975	COG1137	ATPase activity
LI89_RS18980	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
LI89_RS18995	COG1660	Displays ATPase and GTPase activities
LI89_RS19000	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LI89_RS19010	COG0540	Belongs to the ATCase OTCase family
LI89_RS19015	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
LI89_RS19025	COG2308	Evidence 4 Homologs of previously reported genes of
LI89_RS19045	COG0366	Alpha amylase catalytic
LI89_RS19050	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LI89_RS19050	COG1263	PTS System
LI89_RS19060	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
LI89_RS19070	COG3093	addiction module antidote protein HigA
LI89_RS19075	COG3711	transcriptional antiterminator
LI89_RS19075	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LI89_RS19080	COG2706	6-phosphogluconolactonase activity
LI89_RS19095	COG3964	amidohydrolase
LI89_RS19125	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LI89_RS19130	COG3783	Cytochrome b(562)
LI89_RS19135	COG0312	modulator of DNA gyrase
LI89_RS19140	COG3028	Belongs to the UPF0307 family
LI89_RS19145	COG2732	(Barnase) inhibitor
LI89_RS19160	COG1289	transmembrane transporter activity
LI89_RS19165	COG1566	PFAM secretion protein HlyD family protein
LI89_RS19175	COG0583	DNA-binding transcription factor activity
LI89_RS19215	COG0312	modulator of DNA gyrase
LI89_RS19220	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LI89_RS19225	COG3164	Protein of unknown function
LI89_RS19230	COG1530	ribonuclease E activity
LI89_RS19235	COG0424	maF-like protein
LI89_RS19240	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
LI89_RS19245	COG1792	Involved in formation and maintenance of cell shape
LI89_RS19250	COG1077	Cell shape determining protein MreB Mrl
LI89_RS19255	COG2200	EAL domain
LI89_RS19255	COG2199	diguanylate cyclase activity
LI89_RS19260	COG0604	alcohol dehydrogenase
LI89_RS19270	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
LI89_RS19275	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
LI89_RS19280	COG0511	ligase activity, forming carbon-carbon bonds
LI89_RS19285	COG0439	Biotin carboxylase
LI89_RS19290	COG3924	membrane
LI89_RS19295	COG4145	pantothenate transmembrane transporter activity
LI89_RS19300	COG2264	protein methyltransferase activity
LI89_RS19305	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LI89_RS19310	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
LI89_RS19325	COG4626	Terminase
LI89_RS19325	COG1802	Transcriptional regulator
LI89_RS19410	COG0582	viral genome integration into host DNA
LI89_RS19420	COG3133	Outer membrane lipoprotein
LI89_RS19425	COG1278	Cold shock
LI89_RS19430	COG1278	Cold shock
LI89_RS19435	COG1278	Cold shock
LI89_RS19440	COG0471	metal ion transport
LI89_RS19445	COG1560	Kdo2-lipid A biosynthetic process
LI89_RS19455	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LI89_RS19460	COG4597	amino acid ABC transporter
LI89_RS19465	COG0765	amino acid transport
LI89_RS19470	COG1126	abc transporter atp-binding protein
LI89_RS19480	COG1380	Effector of murein hydrolase LrgA
LI89_RS19485	COG0583	DNA-binding transcription factor activity
LI89_RS19490	COG0025	NhaP-type Na H and K H
LI89_RS19495	COG2252	PERMEase
LI89_RS19510	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LI89_RS19515	COG2315	Protein conserved in bacteria
LI89_RS19520	COG1448	Aminotransferase
LI89_RS19550	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LI89_RS19555	COG0735	belongs to the Fur family
LI89_RS19560	COG3237	CsbD-like
LI89_RS19565	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LI89_RS19570	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
LI89_RS19575	COG2937	Belongs to the GPAT DAPAT family
LI89_RS19580	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
LI89_RS19585	COG3161	chorismate lyase activity
LI89_RS19595	COG4580	involved in the transport of maltose and maltodextrins
LI89_RS19605	COG2182	Extracellular solute-binding protein
LI89_RS19610	COG1175	transmembrane transport
LI89_RS19615	COG3833	ABC-type maltose transport systems, permease component
LI89_RS19620	COG3223	Belongs to the PsiE family
LI89_RS19625	COG0166	Belongs to the GPI family
LI89_RS19630	COG0527	aspartate kinase activity
LI89_RS19655	COG1414	Transcriptional regulator
LI89_RS19660	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
LI89_RS19670	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
LI89_RS19675	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
LI89_RS19700	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
LI89_RS19705	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LI89_RS19710	COG0009	L-threonylcarbamoyladenylate synthase
LI89_RS19715	COG0551	DNA topoisomerase type I activity
LI89_RS19725	COG0758	DNA mediated transformation
LI89_RS19730	COG0242	peptide deformylase activity
LI89_RS19735	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LI89_RS19740	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LI89_RS19740	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LI89_RS19750	COG1970	mechanosensitive ion channel activity
LI89_RS19755	COG3036	rescue of stalled ribosome
LI89_RS19760	COG0789	Transcriptional regulator
LI89_RS19770	COG0203	ribosomal protein L17
LI89_RS19775	COG0202	RNA polymerase activity
LI89_RS19780	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
LI89_RS19785	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
LI89_RS19790	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
LI89_RS19795	COG0257	Belongs to the bacterial ribosomal protein bL36 family
LI89_RS19800	COG0201	protein transport
LI89_RS19805	COG0200	Binds to the 23S rRNA
LI89_RS19810	COG1841	ribosomal large subunit assembly
LI89_RS19820	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
LI89_RS19825	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
LI89_RS19835	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
LI89_RS19840	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
LI89_RS19845	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
LI89_RS19850	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
LI89_RS19855	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
LI89_RS19860	COG0255	Belongs to the universal ribosomal protein uL29 family
LI89_RS19865	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
LI89_RS19870	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
LI89_RS19875	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
LI89_RS19880	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
LI89_RS19885	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
LI89_RS19890	COG0089	rRNA binding
LI89_RS19895	COG0088	Forms part of the polypeptide exit tunnel
LI89_RS19900	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
LI89_RS19905	COG0051	transcription antitermination factor activity, RNA binding
LI89_RS19920	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LI89_RS19930	COG0049	tRNA binding
LI89_RS19935	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
LI89_RS19940	COG2168	tRNA wobble position uridine thiolation
LI89_RS19945	COG2923	Belongs to the DsrF TusC family
LI89_RS19950	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
LI89_RS19955	COG2964	Protein conserved in bacteria
LI89_RS19960	COG0545	Peptidyl-prolyl cis-trans isomerase
LI89_RS19965	COG2900	Belongs to the SlyX family
LI89_RS19970	COG1047	Peptidyl-prolyl cis-trans
LI89_RS19975	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
LI89_RS19985	COG2249	NAD(P)H dehydrogenase (quinone) activity
LI89_RS19990	COG0488	(ABC) transporter
LI89_RS19995	COG1216	Glycosyl transferase, family 2
LI89_RS20005	COG2175	clavaminate synthase activity
LI89_RS20010	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LI89_RS20020	COG4521	taurine ABC transporter
LI89_RS20035	COG0429	hydrolase of the alpha beta-hydrolase fold
LI89_RS20040	COG3089	Belongs to the UPF0270 family
LI89_RS20045	COG3954	Phosphoribulokinase
LI89_RS20050	COG1765	OsmC-like protein
LI89_RS20060	COG1289	transmembrane transporter activity
LI89_RS20075	COG0433	COG0433 Predicted ATPase
LI89_RS20080	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LI89_RS20085	COG1486	melibiose metabolic process
LI89_RS20095	COG0738	Major facilitator superfamily
LI89_RS20100	COG0402	S-adenosylhomocysteine deaminase activity
LI89_RS20105	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LI89_RS20120	COG1648	precorrin-2 dehydrogenase activity
LI89_RS20120	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LI89_RS20125	COG0180	Tryptophanyl-tRNA synthetase
LI89_RS20135	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LI89_RS20155	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
LI89_RS20160	COG4796	Type ii and iii secretion system protein
LI89_RS20185	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
LI89_RS20190	COG0494	nUDIX hydrolase
LI89_RS20200	COG1011	Hydrolase
LI89_RS20205	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
LI89_RS20215	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
LI89_RS20230	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LI89_RS20235	COG2183	response to ionizing radiation
LI89_RS20240	COG1918	ferrous iron import across plasma membrane
LI89_RS20245	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
LI89_RS20260	COG0596	Alpha beta hydrolase
LI89_RS20270	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
LI89_RS20270	COG0316	Belongs to the HesB IscA family
LI89_RS20275	COG1640	4-alpha-glucanotransferase
LI89_RS20280	COG0058	SHG alpha-glucan phosphorylase activity
LI89_RS20285	COG2909	trisaccharide binding
LI89_RS20300	COG0705	Rhomboid family
LI89_RS20305	COG1349	DNA-binding transcription factor activity
LI89_RS20310	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
LI89_RS20315	COG0058	SHG alpha-glucan phosphorylase activity
LI89_RS20320	COG0297	glycogen (starch) synthase activity
LI89_RS20330	COG1523	belongs to the glycosyl hydrolase 13 family
LI89_RS20335	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
LI89_RS20340	COG3275	phosphorelay sensor kinase activity
LI89_RS20360	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LI89_RS20365	COG2095	MarC family integral membrane protein
LI89_RS20370	COG3265	gluconokinase activity
LI89_RS20375	COG2610	gluconate transmembrane transporter activity
LI89_RS20380	COG1609	Transcriptional regulator
LI89_RS20385	COG1741	Belongs to the pirin family
LI89_RS20390	COG1247	-acetyltransferase
LI89_RS20395	COG1082	Xylose isomerase domain protein TIM barrel
LI89_RS20400	COG0673	inositol 2-dehydrogenase activity
LI89_RS20410	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LI89_RS20420	COG3718	enzyme involved in inositol metabolism
LI89_RS20435	COG2814	Major facilitator Superfamily
LI89_RS20440	COG0583	DNA-binding transcription factor activity
LI89_RS20450	COG0561	phosphatase activity
LI89_RS20460	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
LI89_RS20460	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
LI89_RS20465	COG0583	DNA-binding transcription factor activity
LI89_RS20470	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LI89_RS20470	COG1648	precorrin-2 dehydrogenase activity
LI89_RS20480	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LI89_RS20490	COG4865	methylaspartate mutase activity
LI89_RS20495	COG3799	methylaspartate ammonia-lyase activity
LI89_RS20510	COG1301	dicarboxylic acid transport
LI89_RS20515	COG2081	HI0933 family
LI89_RS20520	COG0306	phosphate transporter
LI89_RS20530	COG0589	response to stress
LI89_RS20545	COG0742	ribosomal rna small subunit methyltransferase
LI89_RS20555	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
LI89_RS20560	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LI89_RS20610	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LI89_RS20660	COG1396	sequence-specific DNA binding
LI89_RS20675	COG1295	ribonuclease BN
LI89_RS20680	COG2134	cdp-diacylglycerol pyrophosphatase
LI89_RS20685	COG2982	Protein involved in outer membrane biogenesis
LI89_RS20690	COG2200	EAL domain
LI89_RS20695	COG1942	4-Oxalocrotonate Tautomerase
LI89_RS20700	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LI89_RS20705	COG0612	Peptidase, M16
LI89_RS20710	COG1301	dicarboxylic acid transport
LI89_RS20725	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
LI89_RS20730	COG2199	diguanylate cyclase activity
LI89_RS20730	COG2200	EAL domain
LI89_RS20735	COG0457	Tetratricopeptide repeat
LI89_RS20735	COG3118	belongs to the thioredoxin family
LI89_RS20740	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
LI89_RS20745	COG1215	transferase activity, transferring glycosyl groups
LI89_RS20760	COG1192	Involved in chromosome partitioning
LI89_RS20780	COG2194	sulfuric ester hydrolase activity
LI89_RS20785	COG4608	Belongs to the ABC transporter superfamily
LI89_RS20790	COG0444	Belongs to the ABC transporter superfamily
LI89_RS20795	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LI89_RS20800	COG0601	transmembrane transport
LI89_RS20805	COG0747	negative chemotaxis
LI89_RS20810	COG3210	domain, Protein
LI89_RS20815	COG2831	hemolysin activation secretion protein
LI89_RS20820	COG3210	domain, Protein
LI89_RS20830	COG2271	Major facilitator Superfamily
LI89_RS20835	COG3851	Histidine kinase
LI89_RS20840	COG2197	response regulator
LI89_RS20845	COG2194	sulfuric ester hydrolase activity
LI89_RS20850	COG1764	response to oxidative stress
LI89_RS20865	COG2986	histidine ammonia-lyase
LI89_RS20870	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
LI89_RS20890	COG1482	cell wall glycoprotein biosynthetic process
LI89_RS20895	COG2723	6-phospho-beta-galactosidase activity
LI89_RS20910	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LI89_RS20915	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LI89_RS20920	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LI89_RS20925	COG1447	Phosphotransferase system cellobiose-specific component IIA
LI89_RS20930	COG1940	carbohydrate kinase activity
LI89_RS20935	COG1609	Transcriptional regulator
LI89_RS20990	COG0582	viral genome integration into host DNA
LI89_RS20995	COG2207	Transcriptional regulator
LI89_RS20995	COG1609	Transcriptional regulator
LI89_RS21000	COG4214	carbohydrate transport
LI89_RS21010	COG4213	ABC transporter substrate-binding protein
LI89_RS21015	COG2115	Belongs to the xylose isomerase family
LI89_RS21020	COG1070	Carbohydrate kinase
LI89_RS21025	COG3121	Chaperone
LI89_RS21040	COG3274	enterobacterial common antigen metabolic process
LI89_RS21050	COG3276	selenocysteine insertion sequence binding
LI89_RS21055	COG1921	L-seryl-tRNASec selenium transferase activity
LI89_RS21060	COG3058	Necessary for formate dehydrogenase activity
LI89_RS21065	COG2864	formate dehydrogenase
LI89_RS21070	COG0437	4 iron, 4 sulfur cluster binding
LI89_RS21075	COG3383	formate dehydrogenase (NAD+) activity
LI89_RS21075	COG0243	molybdopterin cofactor binding
LI89_RS21080	COG3383	formate dehydrogenase (NAD+) activity
LI89_RS21080	COG0243	molybdopterin cofactor binding
LI89_RS21085	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
LI89_RS21090	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
LI89_RS21095	COG0840	transmembrane signaling receptor activity
LI89_RS21100	COG2258	MOSC domain
LI89_RS21120	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LI89_RS21130	COG3722	fumarate hydratase activity
LI89_RS21135	COG0246	Mannitol dehydrogenase
LI89_RS21140	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
LI89_RS21140	COG2213	PTS system mannitol-specific
LI89_RS21150	COG0751	glycine-tRNA ligase activity
LI89_RS21155	COG0752	glycyl-tRNA synthetase alpha subunit
LI89_RS21160	COG2818	Glycosylase
LI89_RS21180	COG2885	chlorophyll binding
LI89_RS21195	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LI89_RS21200	COG0366	Alpha amylase catalytic
LI89_RS21205	COG3977	Valine--pyruvate aminotransferase
LI89_RS21210	COG0569	domain protein
LI89_RS21210	COG2985	domain, Protein
LI89_RS21225	COG5645	(Lipo)protein
LI89_RS21230	COG0823	Involved in the tonB-independent uptake of proteins
LI89_RS21235	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LI89_RS21240	COG2423	ornithine cyclodeaminase activity
LI89_RS21245	COG1940	carbohydrate kinase activity
LI89_RS21250	COG0561	phosphatase activity
LI89_RS21255	COG0187	DNA topoisomerase II activity
LI89_RS21260	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
LI89_RS21265	COG0592	DNA-directed DNA polymerase activity
LI89_RS21270	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LI89_RS21275	COG0230	Belongs to the bacterial ribosomal protein bL34 family
LI89_RS21280	COG0594	ribonuclease P activity
LI89_RS21290	COG0706	membrane insertase activity
LI89_RS21295	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
LI89_RS21300	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
LI89_RS21315	COG2011	ABC-type metal ion transport system permease component
LI89_RS21320	COG0840	transmembrane signaling receptor activity
LI89_RS21325	COG0431	NADPH-dependent FMN reductase
LI89_RS21330	COG4191	Histidine kinase
LI89_RS21335	COG4566	intracellular signal transduction
LI89_RS21345	COG2252	PERMEase
LI89_RS21350	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LI89_RS21355	COG0765	amino acid transport
LI89_RS21360	COG0765	amino acid transport
LI89_RS21365	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LI89_RS21375	COG0704	Plays a role in the regulation of phosphate uptake
LI89_RS21385	COG0581	inorganic phosphate transmembrane transporter activity
LI89_RS21390	COG0573	inorganic phosphate transmembrane transporter activity
LI89_RS21395	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
LI89_RS21405	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
LI89_RS21410	COG0355	proton-transporting ATP synthase activity, rotational mechanism
LI89_RS21415	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
LI89_RS21420	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
LI89_RS21425	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
LI89_RS21430	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LI89_RS21435	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
LI89_RS21445	COG0356	it plays a direct role in the translocation of protons across the membrane
LI89_RS21450	COG3312	ion transport
LI89_RS21455	COG0357	Ribosomal RNA small subunit methyltransferase G
LI89_RS21460	COG0445	tRNA wobble uridine modification
LI89_RS21720	COG0786	glutamate:sodium symporter activity
LI89_RS21880	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
LI89_RS21910	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide