locus-tag	class	description
LC20_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LC20_RS00010	COG0592	DNA-directed DNA polymerase activity
LC20_RS00020	COG0187	DNA topoisomerase II activity
LC20_RS00025	COG0561	phosphatase activity
LC20_RS00035	COG3121	Chaperone
LC20_RS00040	COG3188	usher protein
LC20_RS00050	COG2423	ornithine cyclodeaminase activity
LC20_RS00065	COG0823	Involved in the tonB-independent uptake of proteins
LC20_RS00070	COG5645	(Lipo)protein
LC20_RS00095	COG3977	Valine--pyruvate aminotransferase
LC20_RS00100	COG0366	Alpha amylase catalytic
LC20_RS00125	COG0456	acetyltransferase
LC20_RS00130	COG2818	Glycosylase
LC20_RS00135	COG0752	glycyl-tRNA synthetase alpha subunit
LC20_RS00140	COG0751	glycine-tRNA ligase activity
LC20_RS00150	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
LC20_RS00150	COG2213	PTS system mannitol-specific
LC20_RS00155	COG0246	Mannitol dehydrogenase
LC20_RS00160	COG3722	fumarate hydratase activity
LC20_RS00170	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LC20_RS00180	COG2258	MOSC domain
LC20_RS00185	COG0840	transmembrane signaling receptor activity
LC20_RS00190	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
LC20_RS00195	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
LC20_RS00200	COG3383	formate dehydrogenase (NAD+) activity
LC20_RS00200	COG0243	molybdopterin cofactor binding
LC20_RS00205	COG0243	molybdopterin cofactor binding
LC20_RS00205	COG3383	formate dehydrogenase (NAD+) activity
LC20_RS00210	COG0437	4 iron, 4 sulfur cluster binding
LC20_RS00215	COG2864	formate dehydrogenase
LC20_RS00220	COG3058	Necessary for formate dehydrogenase activity
LC20_RS00225	COG1921	L-seryl-tRNASec selenium transferase activity
LC20_RS00230	COG3276	selenocysteine insertion sequence binding
LC20_RS00240	COG3274	enterobacterial common antigen metabolic process
LC20_RS00250	COG1335	isochorismatase
LC20_RS00255	COG3121	Chaperone
LC20_RS00260	COG1070	Carbohydrate kinase
LC20_RS00265	COG2115	Belongs to the xylose isomerase family
LC20_RS00270	COG4213	ABC transporter substrate-binding protein
LC20_RS00280	COG4214	carbohydrate transport
LC20_RS00285	COG2207	Transcriptional regulator
LC20_RS00285	COG1609	Transcriptional regulator
LC20_RS00295	COG0582	viral genome integration into host DNA
LC20_RS00325	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
LC20_RS00330	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
LC20_RS00390	COG2003	Belongs to the UPF0758 family
LC20_RS00440	COG1393	Belongs to the ArsC family
LC20_RS00460	COG1609	Transcriptional regulator
LC20_RS00465	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
LC20_RS00470	COG2986	histidine ammonia-lyase
LC20_RS00500	COG0463	Glycosyl transferase, family 2
LC20_RS00505	COG1090	epimerase
LC20_RS00520	COG1764	response to oxidative stress
LC20_RS00525	COG2194	sulfuric ester hydrolase activity
LC20_RS00530	COG2197	response regulator
LC20_RS00535	COG3851	Histidine kinase
LC20_RS00555	COG2831	hemolysin activation secretion protein
LC20_RS00570	COG3210	domain, Protein
LC20_RS00575	COG0747	negative chemotaxis
LC20_RS00580	COG0601	transmembrane transport
LC20_RS00585	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LC20_RS00590	COG0444	Belongs to the ABC transporter superfamily
LC20_RS00595	COG4608	Belongs to the ABC transporter superfamily
LC20_RS00605	COG2194	sulfuric ester hydrolase activity
LC20_RS00625	COG1192	Involved in chromosome partitioning
LC20_RS00630	COG1215	transferase activity, transferring glycosyl groups
LC20_RS00640	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
LC20_RS00645	COG0457	Tetratricopeptide repeat
LC20_RS00645	COG3118	belongs to the thioredoxin family
LC20_RS00655	COG2199	diguanylate cyclase activity
LC20_RS00655	COG2200	EAL domain
LC20_RS00660	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
LC20_RS00675	COG1301	dicarboxylic acid transport
LC20_RS00680	COG0612	Peptidase, M16
LC20_RS00685	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LC20_RS00690	COG1942	4-Oxalocrotonate Tautomerase
LC20_RS00695	COG2200	EAL domain
LC20_RS00700	COG2982	Protein involved in outer membrane biogenesis
LC20_RS00710	COG0477	Major facilitator Superfamily
LC20_RS00715	COG1295	ribonuclease BN
LC20_RS00725	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LC20_RS00730	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
LC20_RS00745	COG0742	ribosomal rna small subunit methyltransferase
LC20_RS00760	COG0589	response to stress
LC20_RS00770	COG0306	phosphate transporter
LC20_RS00805	COG3799	methylaspartate ammonia-lyase activity
LC20_RS00810	COG4865	methylaspartate mutase activity
LC20_RS00820	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LC20_RS00835	COG1648	precorrin-2 dehydrogenase activity
LC20_RS00835	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LC20_RS00840	COG0583	DNA-binding transcription factor activity
LC20_RS00855	COG0561	phosphatase activity
LC20_RS00865	COG2814	Major facilitator Superfamily
LC20_RS00890	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LC20_RS00895	COG3962	Belongs to the TPP enzyme family
LC20_RS00900	COG0673	inositol 2-dehydrogenase activity
LC20_RS00905	COG1082	Xylose isomerase domain protein TIM barrel
LC20_RS00910	COG1247	-acetyltransferase
LC20_RS00915	COG1741	Belongs to the pirin family
LC20_RS00920	COG1609	Transcriptional regulator
LC20_RS00925	COG2610	gluconate transmembrane transporter activity
LC20_RS00930	COG3265	gluconokinase activity
LC20_RS00935	COG2095	MarC family integral membrane protein
LC20_RS00940	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LC20_RS00955	COG3275	phosphorelay sensor kinase activity
LC20_RS00960	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
LC20_RS00965	COG1523	belongs to the glycosyl hydrolase 13 family
LC20_RS00975	COG0297	glycogen (starch) synthase activity
LC20_RS00980	COG0058	SHG alpha-glucan phosphorylase activity
LC20_RS00985	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
LC20_RS00990	COG1349	DNA-binding transcription factor activity
LC20_RS00995	COG0705	Rhomboid family
LC20_RS01005	COG2909	trisaccharide binding
LC20_RS01010	COG0058	SHG alpha-glucan phosphorylase activity
LC20_RS01015	COG1640	4-alpha-glucanotransferase
LC20_RS01020	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
LC20_RS01020	COG0316	Belongs to the HesB IscA family
LC20_RS01025	COG1040	competence protein
LC20_RS01030	COG0596	Alpha beta hydrolase
LC20_RS01050	COG1918	ferrous iron import across plasma membrane
LC20_RS01070	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LC20_RS01085	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
LC20_RS01095	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
LC20_RS01100	COG1011	Hydrolase
LC20_RS01110	COG0494	nUDIX hydrolase
LC20_RS01115	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
LC20_RS01140	COG4796	Type ii and iii secretion system protein
LC20_RS01145	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
LC20_RS01165	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LC20_RS01175	COG0180	Tryptophanyl-tRNA synthetase
LC20_RS01180	COG1648	precorrin-2 dehydrogenase activity
LC20_RS01180	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LC20_RS01195	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LC20_RS01200	COG0402	S-adenosylhomocysteine deaminase activity
LC20_RS01205	COG0738	Major facilitator superfamily
LC20_RS01225	COG1486	melibiose metabolic process
LC20_RS01230	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LC20_RS01235	COG0433	COG0433 Predicted ATPase
LC20_RS01250	COG1289	transmembrane transporter activity
LC20_RS01260	COG1765	OsmC-like protein
LC20_RS01265	COG3954	Phosphoribulokinase
LC20_RS01270	COG3089	Belongs to the UPF0270 family
LC20_RS01275	COG0429	hydrolase of the alpha beta-hydrolase fold
LC20_RS01290	COG4521	taurine ABC transporter
LC20_RS01300	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LC20_RS01305	COG2175	clavaminate synthase activity
LC20_RS01315	COG0488	(ABC) transporter
LC20_RS01320	COG2249	NAD(P)H dehydrogenase (quinone) activity
LC20_RS01330	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
LC20_RS01335	COG1047	Peptidyl-prolyl cis-trans
LC20_RS01340	COG2900	Belongs to the SlyX family
LC20_RS01345	COG0545	Peptidyl-prolyl cis-trans isomerase
LC20_RS01350	COG2964	Protein conserved in bacteria
LC20_RS01360	COG2923	Belongs to the DsrF TusC family
LC20_RS01365	COG2168	tRNA wobble position uridine thiolation
LC20_RS01370	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
LC20_RS01375	COG0049	tRNA binding
LC20_RS01405	COG0051	transcription antitermination factor activity, RNA binding
LC20_RS01410	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
LC20_RS01415	COG0088	Forms part of the polypeptide exit tunnel
LC20_RS01420	COG0089	rRNA binding
LC20_RS01430	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
LC20_RS01440	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
LC20_RS01445	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
LC20_RS01450	COG0255	Belongs to the universal ribosomal protein uL29 family
LC20_RS01455	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
LC20_RS01460	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
LC20_RS01470	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
LC20_RS01475	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
LC20_RS01485	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
LC20_RS01495	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
LC20_RS01500	COG1841	ribosomal large subunit assembly
LC20_RS01505	COG0200	Binds to the 23S rRNA
LC20_RS01510	COG0201	protein transport
LC20_RS01515	COG0257	Belongs to the bacterial ribosomal protein bL36 family
LC20_RS01520	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
LC20_RS01525	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
LC20_RS01530	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
LC20_RS01535	COG0202	RNA polymerase activity
LC20_RS01540	COG0203	ribosomal protein L17
LC20_RS01550	COG0789	Transcriptional regulator
LC20_RS01555	COG3036	rescue of stalled ribosome
LC20_RS01560	COG1970	mechanosensitive ion channel activity
LC20_RS01570	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LC20_RS01570	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LC20_RS01575	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LC20_RS01580	COG0242	peptide deformylase activity
LC20_RS01585	COG0758	DNA mediated transformation
LC20_RS01610	COG5301	cellulose 1,4-beta-cellobiosidase activity
LC20_RS01710	COG4695	Portal protein
LC20_RS01790	COG4974	Belongs to the 'phage' integrase family
LC20_RS01805	COG0551	DNA topoisomerase type I activity
LC20_RS01810	COG0009	L-threonylcarbamoyladenylate synthase
LC20_RS01815	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LC20_RS01820	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
LC20_RS01860	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
LC20_RS01865	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
LC20_RS01870	COG2224	Isocitrate lyase
LC20_RS01875	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
LC20_RS01890	COG0527	aspartate kinase activity
LC20_RS01905	COG3833	ABC-type maltose transport systems, permease component
LC20_RS01910	COG1175	transmembrane transport
LC20_RS01915	COG2182	Extracellular solute-binding protein
LC20_RS01930	COG4580	involved in the transport of maltose and maltodextrins
LC20_RS01945	COG3161	chorismate lyase activity
LC20_RS01950	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
LC20_RS01955	COG2937	Belongs to the GPAT DAPAT family
LC20_RS01960	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
LC20_RS01965	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LC20_RS01970	COG3237	CsbD-like
LC20_RS01975	COG3328	transposase activity
LC20_RS01980	COG0735	belongs to the Fur family
LC20_RS02025	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
LC20_RS02030	COG5532	Uncharacterized conserved protein (DUF2303)
LC20_RS02045	COG0681	Belongs to the peptidase S26 family
LC20_RS02065	COG1802	Transcriptional regulator
LC20_RS02065	COG4626	Terminase
LC20_RS02070	COG4725	Belongs to the MT-A70-like family
LC20_RS02080	COG3645	SOS response
LC20_RS02080	COG3646	Phage regulatory protein
LC20_RS02085	COG1403	HNH endonuclease
LC20_RS02105	COG3772	lysozyme
LC20_RS02190	COG4386	tail sheath protein
LC20_RS02270	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LC20_RS02300	COG1448	Aminotransferase
LC20_RS02305	COG2315	Protein conserved in bacteria
LC20_RS02310	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LC20_RS02325	COG2252	PERMEase
LC20_RS02330	COG0025	NhaP-type Na H and K H
LC20_RS02335	COG0583	DNA-binding transcription factor activity
LC20_RS02340	COG1380	Effector of murein hydrolase LrgA
LC20_RS02350	COG1126	abc transporter atp-binding protein
LC20_RS02355	COG0765	amino acid transport
LC20_RS02360	COG4597	amino acid ABC transporter
LC20_RS02365	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LC20_RS02375	COG1560	Kdo2-lipid A biosynthetic process
LC20_RS02380	COG0471	metal ion transport
LC20_RS02390	COG1278	Cold shock
LC20_RS02395	COG1278	Cold shock
LC20_RS02400	COG3133	Outer membrane lipoprotein
LC20_RS02405	COG3706	GGDEF domain
LC20_RS02410	COG0582	viral genome integration into host DNA
LC20_RS02505	COG1802	Transcriptional regulator
LC20_RS02505	COG4626	Terminase
LC20_RS02520	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
LC20_RS02525	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LC20_RS02530	COG2264	protein methyltransferase activity
LC20_RS02535	COG4145	pantothenate transmembrane transporter activity
LC20_RS02540	COG3924	membrane
LC20_RS02545	COG0439	Biotin carboxylase
LC20_RS02550	COG0511	ligase activity, forming carbon-carbon bonds
LC20_RS02555	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
LC20_RS02560	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
LC20_RS02570	COG0604	alcohol dehydrogenase
LC20_RS02575	COG2200	EAL domain
LC20_RS02575	COG2199	diguanylate cyclase activity
LC20_RS02585	COG1792	Involved in formation and maintenance of cell shape
LC20_RS02590	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
LC20_RS02595	COG0424	maF-like protein
LC20_RS02600	COG1530	ribonuclease E activity
LC20_RS02605	COG3164	Protein of unknown function
LC20_RS02610	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LC20_RS02615	COG0312	modulator of DNA gyrase
LC20_RS02620	COG0583	DNA-binding transcription factor activity
LC20_RS02630	COG1566	PFAM secretion protein HlyD family protein
LC20_RS02635	COG1289	transmembrane transporter activity
LC20_RS02650	COG2732	(Barnase) inhibitor
LC20_RS02655	COG3028	Belongs to the UPF0307 family
LC20_RS02660	COG0312	modulator of DNA gyrase
LC20_RS02665	COG3783	Cytochrome b(562)
LC20_RS02670	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LC20_RS02700	COG3964	amidohydrolase
LC20_RS02715	COG2706	6-phosphogluconolactonase activity
LC20_RS02720	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LC20_RS02720	COG3711	transcriptional antiterminator
LC20_RS02725	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
LC20_RS02730	COG1609	Transcriptional regulator
LC20_RS02735	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LC20_RS02735	COG1263	PTS System
LC20_RS02740	COG0366	Alpha amylase catalytic
LC20_RS02760	COG2308	Evidence 4 Homologs of previously reported genes of
LC20_RS02770	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
LC20_RS02775	COG0540	Belongs to the ATCase OTCase family
LC20_RS02780	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LC20_RS02785	COG1660	Displays ATPase and GTPase activities
LC20_RS02790	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LC20_RS02800	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
LC20_RS02805	COG1137	ATPase activity
LC20_RS02810	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
LC20_RS02815	COG3117	lipopolysaccharide transmembrane transporter activity
LC20_RS02820	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
LC20_RS02825	COG0517	IMP dehydrogenase activity
LC20_RS02825	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
LC20_RS02830	COG0530	calcium, potassium:sodium antiporter activity
LC20_RS02835	COG1127	ABC transporter
LC20_RS02840	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LC20_RS02845	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
LC20_RS02850	COG2854	intermembrane phospholipid transfer
LC20_RS02855	COG3113	response to antibiotic
LC20_RS02860	COG5007	Belongs to the BolA IbaG family
LC20_RS02865	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LC20_RS02870	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LC20_RS02875	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LC20_RS02880	COG3105	Protein conserved in bacteria
LC20_RS02885	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
LC20_RS02890	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
LC20_RS02895	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
LC20_RS02900	COG0625	glutathione transferase activity
LC20_RS02905	COG2969	positive regulation of protein catabolic process
LC20_RS02915	COG0493	'glutamate synthase
LC20_RS02920	COG0067	glutamate synthase
LC20_RS02920	COG0069	glutamate synthase activity
LC20_RS02920	COG0070	glutamate synthase
LC20_RS02925	COG1242	4 iron, 4 sulfur cluster binding
LC20_RS02930	COG5002	protein histidine kinase activity
LC20_RS02930	COG0784	Response regulator, receiver
LC20_RS02930	COG2198	Histidine kinase
LC20_RS02940	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
LC20_RS02945	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LC20_RS02950	COG2823	Periplasmic or secreted lipoprotein
LC20_RS02955	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
LC20_RS02960	COG0792	nuclease activity
LC20_RS02970	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
LC20_RS03060	COG0840	transmembrane signaling receptor activity
LC20_RS03085	COG3133	Outer membrane lipoprotein
LC20_RS03090	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
LC20_RS03095	COG0437	4 iron, 4 sulfur cluster binding
LC20_RS03100	COG5557	Pfam Polysulphide reductase, NrfD
LC20_RS03105	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
LC20_RS03110	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
LC20_RS03115	COG1773	rubredoxin
LC20_RS03125	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
LC20_RS03130	COG0298	carbon dioxide binding
LC20_RS03135	COG0409	Hydrogenase expression formation protein
LC20_RS03140	COG0309	Hydrogenase expression formation protein (HypE)
LC20_RS03145	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
LC20_RS03230	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LC20_RS03235	COG2271	Major facilitator Superfamily
LC20_RS03240	COG1028	Short-chain dehydrogenase reductase Sdr
LC20_RS03245	COG1535	isochorismatase
LC20_RS03245	COG3433	isochorismatase activity
LC20_RS03250	COG1021	2,3-dihydroxybenzoate-AMP ligase
LC20_RS03255	COG1169	isochorismate synthase
LC20_RS03260	COG4592	Periplasmic binding protein
LC20_RS03270	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LC20_RS03275	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LC20_RS03280	COG1120	ATPase activity
LC20_RS03285	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LC20_RS03300	COG4774	siderophore transport
LC20_RS03310	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LC20_RS03320	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LC20_RS03350	COG4964	Belongs to the GSP D family
LC20_RS03410	COG0848	biopolymer transport protein
LC20_RS03425	COG0586	Pfam SNARE associated Golgi protein
LC20_RS03430	COG2207	Transcriptional regulator
LC20_RS03435	COG1979	alcohol dehydrogenase
LC20_RS03440	COG0656	L-ascorbic acid biosynthetic process
LC20_RS03450	COG2132	Multicopper oxidase
LC20_RS03465	COG2249	NAD(P)H dehydrogenase (quinone) activity
LC20_RS03470	COG0583	DNA-binding transcription factor activity
LC20_RS03480	COG3150	esterase
LC20_RS03485	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
LC20_RS03490	COG3151	Protein conserved in bacteria
LC20_RS03495	COG0494	nUDIX hydrolase
LC20_RS03500	COG1538	Outer membrane efflux protein
LC20_RS03510	COG0754	glutathionylspermidine amidase activity
LC20_RS03515	COG3384	dioxygenase
LC20_RS03520	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LC20_RS03530	COG0531	amino acid
LC20_RS03535	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
LC20_RS03535	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
LC20_RS03540	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
LC20_RS03545	COG3025	triphosphatase activity
LC20_RS03550	COG4991	sh3 domain protein
LC20_RS03555	COG0617	tRNA 3'-terminal CCA addition
LC20_RS03560	COG1968	undecaprenyl-diphosphatase activity
LC20_RS03565	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
LC20_RS03570	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
LC20_RS03575	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
LC20_RS03580	COG0828	Belongs to the bacterial ribosomal protein bS21 family
LC20_RS03585	COG0358	DNA primase activity
LC20_RS03715	COG3876	Protein conserved in bacteria
LC20_RS03725	COG1472	Belongs to the glycosyl hydrolase 3 family
LC20_RS03735	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
LC20_RS03740	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LC20_RS03740	COG1263	PTS System
LC20_RS03750	COG0531	amino acid
LC20_RS03755	COG0076	glutamate decarboxylase activity
LC20_RS03765	COG2814	Major facilitator Superfamily
LC20_RS03770	COG3247	response to pH
LC20_RS03780	COG1902	pentaerythritol trinitrate reductase activity
LC20_RS03780	COG0446	pyridine nucleotide-disulphide oxidoreductase
LC20_RS03785	COG2813	Specifically methylates the guanine in position
LC20_RS03795	COG1451	nucleotide metabolic process
LC20_RS03800	COG0673	inositol 2-dehydrogenase activity
LC20_RS03810	COG0861	Integral membrane protein TerC family
LC20_RS03815	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
LC20_RS03825	COG2721	sulfolactate sulfo-lyase activity
LC20_RS03830	COG0246	Mannitol dehydrogenase
LC20_RS03835	COG1904	glucuronate isomerase
LC20_RS03840	COG2271	Major facilitator Superfamily
LC20_RS03855	COG0586	Pfam SNARE associated Golgi protein
LC20_RS03870	COG4575	ribosome binding
LC20_RS03875	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
LC20_RS03885	COG2259	Doxx family
LC20_RS03890	COG0435	Glutathione S-transferase
LC20_RS03895	COG0583	DNA-binding transcription factor activity
LC20_RS03900	COG1741	Belongs to the pirin family
LC20_RS03945	COG2885	chlorophyll binding
LC20_RS04095	COG0288	reversible hydration of carbon dioxide
LC20_RS04100	COG1733	regulation of RNA biosynthetic process
LC20_RS04105	COG1028	Short-chain dehydrogenase reductase Sdr
LC20_RS04120	COG0484	heat shock protein binding
LC20_RS04125	COG1609	Transcriptional regulator
LC20_RS04130	COG2271	Major facilitator Superfamily
LC20_RS04145	COG1522	sequence-specific DNA binding
LC20_RS04170	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
LC20_RS04180	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
LC20_RS04185	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LC20_RS04190	COG4974	Belongs to the 'phage' integrase family
LC20_RS04195	COG0716	FMN binding
LC20_RS04200	COG4452	Inner membrane protein CreD
LC20_RS04205	COG2205	protein histidine kinase activity
LC20_RS04210	COG0745	RESPONSE REGULATOR receiver
LC20_RS04225	COG0354	folic acid binding
LC20_RS04230	COG1272	protein, Hemolysin III
LC20_RS04240	COG1028	Short-chain dehydrogenase reductase Sdr
LC20_RS04250	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LC20_RS04250	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LC20_RS04255	COG0509	glycine decarboxylation via glycine cleavage system
LC20_RS04260	COG0404	The glycine cleavage system catalyzes the degradation of glycine
LC20_RS04265	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LC20_RS04270	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LC20_RS04275	COG0006	proline dipeptidase activity
LC20_RS04280	COG3079	Belongs to the UPF0149 family
LC20_RS04285	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
LC20_RS04295	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LC20_RS04300	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LC20_RS04305	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
LC20_RS04310	COG0583	DNA-binding transcription factor activity
LC20_RS04320	COG1279	arginine transmembrane transporter activity
LC20_RS04330	COG0191	fructose-bisphosphate aldolase activity
LC20_RS04335	COG0126	phosphoglycerate kinase activity
LC20_RS04340	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LC20_RS04350	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
LC20_RS04355	COG0501	Belongs to the peptidase M48B family
LC20_RS04365	COG1166	arginine decarboxylase activity
LC20_RS04385	COG0640	Transcriptional regulator
LC20_RS04390	COG3091	SprT-like family
LC20_RS04395	COG2356	endonuclease I
LC20_RS04400	COG1385	rRNA (uridine-N3-)-methyltransferase activity
LC20_RS04405	COG0189	ligase activity
LC20_RS04410	COG1678	Uncharacterized ACR, COG1678
LC20_RS04415	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
LC20_RS04420	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LC20_RS04430	COG2805	Type II/IV secretion system protein
LC20_RS04435	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
LC20_RS04440	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
LC20_RS04445	COG0762	integral membrane protein
LC20_RS04450	COG1872	DUF167
LC20_RS04455	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
LC20_RS04460	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LC20_RS04475	COG3171	Protein conserved in bacteria
LC20_RS04485	COG2814	Major facilitator Superfamily
LC20_RS04495	COG0220	tRNA (guanine-N7-)-methyltransferase activity
LC20_RS04500	COG1194	a g-specific adenine glycosylase
LC20_RS04505	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
LC20_RS04510	COG0741	lytic transglycosylase activity
LC20_RS04520	COG1982	Orn Lys Arg decarboxylase major
LC20_RS04530	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
LC20_RS04595	COG3328	transposase activity
LC20_RS04630	COG2165	general secretion pathway protein
LC20_RS04685	COG0583	DNA-binding transcription factor activity
LC20_RS04690	COG2814	Major facilitator Superfamily
LC20_RS04695	COG0583	DNA-binding transcription factor activity
LC20_RS04705	COG1609	Transcriptional regulator
LC20_RS04715	COG0204	Acyl-transferase
LC20_RS04715	COG0318	PFAM AMP-dependent synthetase and ligase
LC20_RS04720	COG0477	Major facilitator Superfamily
LC20_RS04725	COG0667	Aldo Keto reductase
LC20_RS04730	COG0861	Integral membrane protein TerC family
LC20_RS04735	COG3066	DNA modification
LC20_RS04745	COG1051	belongs to the nudix hydrolase family
LC20_RS04755	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
LC20_RS04775	COG3328	transposase activity
LC20_RS04785	COG4967	type IV pilus modification protein PilV
LC20_RS04790	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
LC20_RS04795	COG1025	Belongs to the peptidase M16 family
LC20_RS04800	COG1074	ATP-dependent DNA helicase activity
LC20_RS04805	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LC20_RS04810	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
LC20_RS04810	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LC20_RS04815	COG0860	N-Acetylmuramoyl-L-alanine amidase
LC20_RS04835	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
LC20_RS04840	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
LC20_RS04845	COG2166	iron-sulfur cluster assembly
LC20_RS04850	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LC20_RS04860	COG0583	DNA-binding transcription factor activity
LC20_RS04865	COG2363	Small membrane protein
LC20_RS04870	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
LC20_RS04875	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LC20_RS04880	COG1611	Belongs to the LOG family
LC20_RS04885	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
LC20_RS04885	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
LC20_RS04900	COG3423	Transcriptional regulator
LC20_RS04975	COG4382	Mu-like prophage protein Gp16
LC20_RS04990	COG3179	chitinase
LC20_RS05030	COG4383	Mu-like prophage protein gp29
LC20_RS05055	COG4397	Mu-like prophage major head subunit gpT
LC20_RS05145	COG3098	single-species biofilm formation
LC20_RS05150	COG0564	pseudouridine synthase activity
LC20_RS05165	COG2171	N-acyltransferase activity
LC20_RS05170	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
LC20_RS05185	COG0052	Belongs to the universal ribosomal protein uS2 family
LC20_RS05190	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
LC20_RS05195	COG0528	UMP kinase activity
LC20_RS05205	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
LC20_RS05215	COG0575	Belongs to the CDS family
LC20_RS05220	COG0750	zinc metalloprotease
LC20_RS05230	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
LC20_RS05235	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LC20_RS05240	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LC20_RS05245	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LC20_RS05255	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LC20_RS05260	COG0587	DNA-directed DNA polymerase activity
LC20_RS05265	COG0825	malonyl-CoA metabolic process
LC20_RS05270	COG1982	Orn Lys Arg decarboxylase major
LC20_RS05275	COG0346	lactoylglutathione lyase activity
LC20_RS05290	COG4568	rho-dependent transcription termination
LC20_RS05300	COG4681	YaeQ
LC20_RS05310	COG3015	lipoprotein NlpE involved in copper resistance
LC20_RS05315	COG0442	prolyl-tRNA aminoacylation
LC20_RS05320	COG1720	tRNA m6t6A37 methyltransferase activity
LC20_RS05330	COG1464	Belongs to the NlpA lipoprotein family
LC20_RS05335	COG2011	ABC-type metal ion transport system permease component
LC20_RS05345	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
LC20_RS05380	COG5544	Lipoprotein
LC20_RS05385	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LC20_RS05390	COG0045	succinate-CoA ligase (ADP-forming) activity
LC20_RS05390	COG1042	CoA-binding domain protein
LC20_RS05390	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LC20_RS05395	COG3148	PFAM DTW domain containing protein
LC20_RS05400	COG3118	belongs to the thioredoxin family
LC20_RS05405	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LC20_RS05410	COG2814	Major facilitator Superfamily
LC20_RS05415	COG1566	PFAM secretion protein HlyD family protein
LC20_RS05420	COG1538	Outer membrane efflux protein
LC20_RS05425	COG1846	Transcriptional regulator
LC20_RS05435	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
LC20_RS05490	COG0765	amino acid transport
LC20_RS05495	COG0765	amino acid transport
LC20_RS05500	COG1126	abc transporter atp-binding protein
LC20_RS05505	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
LC20_RS05520	COG0436	Aminotransferase
LC20_RS05525	COG0235	Class ii aldolase
LC20_RS05530	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
LC20_RS05535	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
LC20_RS05540	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
LC20_RS05545	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
LC20_RS05560	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
LC20_RS05565	COG1960	acyl-CoA dehydrogenase activity
LC20_RS05575	COG0121	glutamine amidotransferase
LC20_RS05580	COG3034	peptidoglycan biosynthetic process
LC20_RS05585	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
LC20_RS05590	COG1805	sodium ion transport
LC20_RS05595	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
LC20_RS05600	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
LC20_RS05605	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
LC20_RS05610	COG2871	sodium ion transport
LC20_RS05615	COG1477	protein flavinylation
LC20_RS05620	COG2991	Protein conserved in bacteria
LC20_RS05630	COG0584	glycerophosphoryl diester phosphodiesterase
LC20_RS05635	COG1181	Belongs to the D-alanine--D-alanine ligase family
LC20_RS05640	COG2964	Protein conserved in bacteria
LC20_RS05655	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LC20_RS05660	COG2195	Cleaves the N-terminal amino acid of tripeptides
LC20_RS05665	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
LC20_RS05670	COG1073	alpha beta
LC20_RS05680	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
LC20_RS05685	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
LC20_RS05690	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LC20_RS05695	COG2313	pseudouridylate synthase activity
LC20_RS05700	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LC20_RS05705	COG2188	Transcriptional regulator
LC20_RS05735	COG2226	methyltransferase
LC20_RS05750	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LC20_RS05760	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
LC20_RS05765	COG3123	guanosine phosphorylase activity
LC20_RS05770	COG2974	May be involved in recombination
LC20_RS05775	COG1940	carbohydrate kinase activity
LC20_RS05780	COG0419	ATPase involved in DNA repair
LC20_RS05790	COG0745	RESPONSE REGULATOR receiver
LC20_RS05795	COG5002	protein histidine kinase activity
LC20_RS05815	COG0366	Alpha amylase catalytic
LC20_RS05830	COG0450	alkyl hydroperoxide reductase
LC20_RS05835	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
LC20_RS05840	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
LC20_RS05850	COG0343	queuine tRNA-ribosyltransferase activity
LC20_RS05855	COG1862	Preprotein translocase
LC20_RS05860	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LC20_RS05865	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LC20_RS05875	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
LC20_RS05880	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LC20_RS05880	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LC20_RS05885	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
LC20_RS05890	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LC20_RS05895	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
LC20_RS05900	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
LC20_RS05905	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
LC20_RS05910	COG0142	geranyltranstransferase activity
LC20_RS05915	COG1722	exodeoxyribonuclease VII activity
LC20_RS05920	COG0301	tRNA thio-modification
LC20_RS05920	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LC20_RS05945	COG0693	protein deglycase activity
LC20_RS05950	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
LC20_RS05955	COG1666	GTP binding
LC20_RS05960	COG2814	Major facilitator Superfamily
LC20_RS05965	COG0109	protoheme IX farnesyltransferase activity
LC20_RS05970	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
LC20_RS05975	COG1845	cytochrome c oxidase, subunit III
LC20_RS05980	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LC20_RS05985	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
LC20_RS05995	COG2223	nitrite transmembrane transporter activity
LC20_RS06000	COG3056	Lipoprotein
LC20_RS06005	COG0271	Belongs to the BolA IbaG family
LC20_RS06015	COG0544	peptidyl-prolyl cis-trans isomerase activity
LC20_RS06025	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
LC20_RS06030	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
LC20_RS06035	COG0776	regulation of translation
LC20_RS06040	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LC20_RS06045	COG1555	photosystem II stabilization
LC20_RS06055	COG0824	Thioesterase
LC20_RS06060	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
LC20_RS06065	COG4533	DNA binding
LC20_RS06070	COG0561	phosphatase activity
LC20_RS06080	COG1522	sequence-specific DNA binding
LC20_RS06085	COG1132	(ABC) transporter
LC20_RS06090	COG1132	(ABC) transporter
LC20_RS06095	COG0347	Belongs to the P(II) protein family
LC20_RS06100	COG0004	ammonium transporteR
LC20_RS06105	COG1946	Acyl-CoA thioesterase
LC20_RS06110	COG3126	Type III secretion system lipoprotein chaperone (YscW)
LC20_RS06115	COG3695	enzyme binding
LC20_RS06125	COG1470	cell adhesion involved in biofilm formation
LC20_RS06125	COG1388	LysM domain
LC20_RS06145	COG1121	(ABC) transporter
LC20_RS06150	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LC20_RS06155	COG0803	Belongs to the bacterial solute-binding protein 9 family
LC20_RS06160	COG0257	Belongs to the bacterial ribosomal protein bL36 family
LC20_RS06165	COG0254	rRNA binding
LC20_RS06170	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
LC20_RS06175	COG3457	Alanine racemase
LC20_RS06185	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LC20_RS06190	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LC20_RS06195	COG1309	transcriptional regulator
LC20_RS06200	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
LC20_RS06220	COG2832	Protein of unknown function (DUF454)
LC20_RS06225	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LC20_RS06230	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
LC20_RS06240	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
LC20_RS06245	COG0326	Molecular chaperone. Has ATPase activity
LC20_RS06250	COG0563	adenylate kinase activity
LC20_RS06255	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
LC20_RS06265	COG1442	glycosyl transferase family 8
LC20_RS06265	COG1216	Glycosyl transferase, family 2
LC20_RS06270	COG1215	transferase activity, transferring glycosyl groups
LC20_RS06275	COG0438	transferase activity, transferring glycosyl groups
LC20_RS06280	COG0438	transferase activity, transferring glycosyl groups
LC20_RS06285	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LC20_RS06305	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LC20_RS06310	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LC20_RS06310	COG4651	solute:proton antiporter activity
LC20_RS06315	COG2223	nitrite transmembrane transporter activity
LC20_RS06320	COG0737	Belongs to the 5'-nucleotidase family
LC20_RS06335	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
LC20_RS06340	COG3735	TraB family
LC20_RS06345	COG2217	Heavy metal translocating P-type atpase
LC20_RS06350	COG0789	Transcriptional regulator
LC20_RS06355	COG1585	Membrane protein implicated in regulation of membrane protease activity
LC20_RS06360	COG0330	HflC and HflK could
LC20_RS06365	COG3118	belongs to the thioredoxin family
LC20_RS06370	COG0300	oxidoreductase activity
LC20_RS06375	COG2755	lipolytic protein G-D-S-L family
LC20_RS06380	COG4181	ATPase activity
LC20_RS06385	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
LC20_RS06390	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
LC20_RS06395	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
LC20_RS06400	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LC20_RS06405	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LC20_RS06410	COG0215	cysteine-tRNA ligase activity
LC20_RS06415	COG2501	S4 domain
LC20_RS06420	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
LC20_RS06430	COG0582	viral genome integration into host DNA
LC20_RS06675	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LC20_RS06750	COG2850	peptidyl-arginine hydroxylation
LC20_RS06755	COG5265	(ABC) transporter
LC20_RS06775	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
LC20_RS06785	COG2197	response regulator
LC20_RS06790	COG1278	Cold shock
LC20_RS06805	COG3706	GGDEF domain
LC20_RS06810	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LC20_RS06815	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
LC20_RS06820	COG0321	lipoyl(octanoyl) transferase activity
LC20_RS06825	COG2921	Belongs to the UPF0250 family
LC20_RS06830	COG1686	Belongs to the peptidase S11 family
LC20_RS06835	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
LC20_RS06840	COG0772	Belongs to the SEDS family
LC20_RS06845	COG0768	penicillin binding
LC20_RS06855	COG0799	negative regulation of ribosome biogenesis
LC20_RS06860	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
LC20_RS06865	COG1466	dna polymerase III delta subunit
LC20_RS06870	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
LC20_RS06875	COG0495	leucyl-tRNA aminoacylation
LC20_RS06880	COG2888	peptidyl-tyrosine sulfation
LC20_RS06890	COG1126	abc transporter atp-binding protein
LC20_RS06895	COG0765	amino acid transport
LC20_RS06900	COG0765	amino acid transport
LC20_RS06915	COG0815	Transfers the fatty acyl group on membrane lipoproteins
LC20_RS06920	COG4535	Mg2 and Co2 transporter CorC
LC20_RS06925	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
LC20_RS06930	COG1702	phosphate starvation-inducible protein PhoH
LC20_RS06935	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LC20_RS06940	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LC20_RS06975	COG0367	asparagine synthase
LC20_RS06980	COG0647	UMP catabolic process
LC20_RS06985	COG1940	carbohydrate kinase activity
LC20_RS06985	COG1846	Transcriptional regulator
LC20_RS06990	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
LC20_RS06995	COG0363	glucosamine-6-phosphate deaminase activity
LC20_RS07000	COG2190	(PTS) system
LC20_RS07000	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LC20_RS07000	COG1263	PTS System
LC20_RS07005	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LC20_RS07025	COG0735	belongs to the Fur family
LC20_RS07035	COG0840	transmembrane signaling receptor activity
LC20_RS07045	COG0596	Alpha beta hydrolase
LC20_RS07050	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
LC20_RS07055	COG0033	Phosphoglucomutase
LC20_RS07065	COG0745	RESPONSE REGULATOR receiver
LC20_RS07070	COG2205	protein histidine kinase activity
LC20_RS07075	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
LC20_RS07080	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
LC20_RS07085	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
LC20_RS07105	COG3272	Protein of unknown function (DUF1722)
LC20_RS07115	COG5212	phosphodiesterase
LC20_RS07120	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
LC20_RS07125	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
LC20_RS07130	COG1984	allophanate hydrolase subunit 2
LC20_RS07135	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
LC20_RS07150	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
LC20_RS07160	COG2009	succinate dehydrogenase
LC20_RS07165	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
LC20_RS07170	COG1053	succinate dehydrogenase
LC20_RS07180	COG0567	Dehydrogenase, E1 component
LC20_RS07185	COG0508	dehydrogenase complex catalyzes the overall conversion of
LC20_RS07195	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
LC20_RS07200	COG0737	Belongs to the 5'-nucleotidase family
LC20_RS07205	COG1271	oxidase subunit
LC20_RS07210	COG1294	oxidase, subunit
LC20_RS07215	COG4890	Cyd operon protein YbgT
LC20_RS07220	COG3790	cyd operon protein YbgE
LC20_RS07225	COG0824	Thioesterase
LC20_RS07230	COG0811	peptide transport
LC20_RS07235	COG0848	biopolymer transport protein
LC20_RS07240	COG3064	Membrane
LC20_RS07240	COG3064	Membrane
LC20_RS07245	COG0823	Involved in the tonB-independent uptake of proteins
LC20_RS07250	COG2885	chlorophyll binding
LC20_RS07255	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
LC20_RS07290	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
LC20_RS07300	COG1230	cation diffusion facilitator family transporter
LC20_RS07305	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LC20_RS07310	COG0588	phosphoglycerate mutase activity
LC20_RS07320	COG2017	converts alpha-aldose to the beta-anomer
LC20_RS07325	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
LC20_RS07335	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LC20_RS07345	COG1119	ATPase activity
LC20_RS07350	COG3585	molybdate ion transport
LC20_RS07350	COG2005	Transcriptional regulator
LC20_RS07365	COG0725	ABC transporter, periplasmic molybdate-binding protein
LC20_RS07370	COG0582	viral genome integration into host DNA
LC20_RS07440	COG4197	protein conserved in bacteria, prophage-related
LC20_RS07450	COG1484	DNA-dependent DNA replication
LC20_RS07455	COG0305	Participates in initiation and elongation during chromosome replication
LC20_RS07500	COG3179	chitinase
LC20_RS07585	COG4386	tail sheath protein
LC20_RS07645	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LC20_RS07670	COG4149	molybdate abc transporter
LC20_RS07680	COG0561	phosphatase activity
LC20_RS07690	COG2706	6-phosphogluconolactonase activity
LC20_RS07700	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
LC20_RS07705	COG0156	8-amino-7-oxononanoate synthase activity
LC20_RS07710	COG2226	methyltransferase
LC20_RS07725	COG0556	nucleotide-excision repair
LC20_RS07730	COG4628	conserved protein (DUF2132)
LC20_RS07735	COG0391	Required for morphogenesis under gluconeogenic growth conditions
LC20_RS07740	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
LC20_RS07745	COG0315	cyclic pyranopterin monophosphate synthase activity
LC20_RS07750	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
LC20_RS07755	COG0314	molybdopterin synthase activity
LC20_RS07760	COG0670	Belongs to the BI1 family
LC20_RS07765	COG0842	Transport permease protein
LC20_RS07770	COG0842	Transport permease protein
LC20_RS07775	COG1131	(ABC) transporter
LC20_RS07780	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LC20_RS07785	COG1309	transcriptional regulator
LC20_RS07790	COG0513	Belongs to the DEAD box helicase family
LC20_RS07805	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LC20_RS07840	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
LC20_RS07870	COG1686	Belongs to the peptidase S11 family
LC20_RS07875	COG0277	FAD linked oxidase domain protein
LC20_RS07895	COG2261	transglycosylase associated protein
LC20_RS07905	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
LC20_RS07920	COG4807	Protein conserved in bacteria
LC20_RS07940	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
LC20_RS07950	COG2897	thiosulfate sulfurtransferase activity
LC20_RS07955	COG0673	inositol 2-dehydrogenase activity
LC20_RS07965	COG1732	Glycine betaine
LC20_RS07970	COG1174	glycine betaine transport
LC20_RS07975	COG1125	glycine betaine transport
LC20_RS07980	COG1174	glycine betaine transport
LC20_RS07995	COG0697	spore germination
LC20_RS08015	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LC20_RS08020	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LC20_RS08035	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LC20_RS08040	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
LC20_RS08050	COG1126	abc transporter atp-binding protein
LC20_RS08055	COG0765	amino acid transport
LC20_RS08060	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LC20_RS08065	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
LC20_RS08070	COG0783	Belongs to the Dps family
LC20_RS08075	COG4106	trans-aconitate 2-methyltransferase activity
LC20_RS08090	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
LC20_RS08105	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
LC20_RS08125	COG0488	(ABC) transporter
LC20_RS08130	COG3397	chitin binding
LC20_RS08135	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
LC20_RS08140	COG0303	'Molybdopterin
LC20_RS08150	COG0477	Major facilitator Superfamily
LC20_RS08160	COG0577	efflux transmembrane transporter activity
LC20_RS08160	COG1136	(ABC) transporter
LC20_RS08185	COG0583	DNA-binding transcription factor activity
LC20_RS08190	COG0477	Major facilitator Superfamily
LC20_RS08195	COG0302	gtp cyclohydrolase
LC20_RS08200	COG2311	Membrane
LC20_RS08235	COG3383	formate dehydrogenase (NAD+) activity
LC20_RS08240	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
LC20_RS08245	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
LC20_RS08255	COG3260	NADH ubiquinone oxidoreductase 20
LC20_RS08260	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LC20_RS08265	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
LC20_RS08265	COG3261	NADH dehydrogenase
LC20_RS08270	COG0651	ATP synthesis coupled electron transport
LC20_RS08275	COG4237	Hydrogenase 4 membrane
LC20_RS08280	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LC20_RS08285	COG0650	Formate hydrogenlyase subunit 4
LC20_RS08290	COG0651	ATP synthesis coupled electron transport
LC20_RS08295	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
LC20_RS08300	COG0375	protein maturation
LC20_RS08305	COG0298	carbon dioxide binding
LC20_RS08310	COG2949	membrane
LC20_RS08315	COG0281	malic enzyme
LC20_RS08325	COG1346	cytolysis
LC20_RS08330	COG1380	Effector of murein hydrolase LrgA
LC20_RS08335	COG2814	Major facilitator Superfamily
LC20_RS08355	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LC20_RS08355	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LC20_RS08360	COG0489	protein tyrosine kinase activity
LC20_RS08375	COG2982	Protein involved in outer membrane biogenesis
LC20_RS08380	COG3069	C4-dicarboxylate transmembrane transporter activity
LC20_RS08385	COG1253	flavin adenine dinucleotide binding
LC20_RS08410	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LC20_RS08420	COG0438	transferase activity, transferring glycosyl groups
LC20_RS08425	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
LC20_RS08445	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LC20_RS08450	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LC20_RS08460	COG0140	phosphoribosyl-ATP diphosphatase activity
LC20_RS08460	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
LC20_RS08465	COG0107	imidazoleglycerol-phosphate synthase activity
LC20_RS08470	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
LC20_RS08480	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
LC20_RS08480	COG0131	Imidazoleglycerol-phosphate dehydratase
LC20_RS08485	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LC20_RS08495	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
LC20_RS08505	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LC20_RS08510	COG1172	Belongs to the binding-protein-dependent transport system permease family
LC20_RS08520	COG0371	Dehydrogenase
LC20_RS08530	COG0531	amino acid
LC20_RS08535	COG2925	Exonuclease
LC20_RS08540	COG3320	Male sterility
LC20_RS08540	COG1022	Amp-dependent synthetase and ligase
LC20_RS08560	COG1172	Belongs to the binding-protein-dependent transport system permease family
LC20_RS08565	COG1129	ABC transporter
LC20_RS08580	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LC20_RS08585	COG1648	precorrin-2 dehydrogenase activity
LC20_RS08585	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LC20_RS08590	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
LC20_RS08610	COG4656	Part of a membrane complex involved in electron transport
LC20_RS08660	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
LC20_RS08670	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
LC20_RS08735	COG1492	cobalamin metabolic process
LC20_RS08755	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
LC20_RS08760	COG0137	argininosuccinate synthase activity
LC20_RS08765	COG0534	Mate efflux family protein
LC20_RS08770	COG0835	chemotaxis
LC20_RS08770	COG0784	Response regulator, receiver
LC20_RS08780	COG3842	ATPase activity
LC20_RS08790	COG1840	ABC-type Fe3 transport system, periplasmic component
LC20_RS08795	COG2271	Major facilitator Superfamily
LC20_RS08810	COG4565	transcriptional regulatory protein
LC20_RS08815	COG3290	protein histidine kinase activity
LC20_RS08820	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
LC20_RS08825	COG3052	prosthetic group binding
LC20_RS08830	COG2301	Belongs to the HpcH HpaI aldolase family
LC20_RS08835	COG3051	citrate lyase alpha subunit
LC20_RS08840	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
LC20_RS08840	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
LC20_RS08850	COG0471	metal ion transport
LC20_RS08865	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
LC20_RS08915	COG3121	Chaperone
LC20_RS08925	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LC20_RS08925	COG2205	protein histidine kinase activity
LC20_RS08945	COG3228	Belongs to the MtfA family
LC20_RS08955	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LC20_RS08960	COG4589	Belongs to the CDS family
LC20_RS08970	COG2267	carboxylic ester hydrolase activity
LC20_RS08975	COG0671	phosphoesterase, PA-phosphatase related
LC20_RS08975	COG2453	phosphatase
LC20_RS08985	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
LC20_RS09005	COG1522	sequence-specific DNA binding
LC20_RS09015	COG1028	Short-chain dehydrogenase reductase Sdr
LC20_RS09015	COG0604	alcohol dehydrogenase
LC20_RS09015	COG3321	synthase
LC20_RS09020	COG3250	beta-galactosidase activity
LC20_RS09025	COG1609	Transcriptional regulator
LC20_RS09040	COG0840	transmembrane signaling receptor activity
LC20_RS09045	COG1285	pathogenesis
LC20_RS09055	COG0589	response to stress
LC20_RS09075	COG1360	Flagellar Motor Protein
LC20_RS09080	COG2198	Histidine kinase
LC20_RS09080	COG0643	Histidine kinase
LC20_RS09085	COG0835	chemotaxis
LC20_RS09090	COG0840	transmembrane signaling receptor activity
LC20_RS09095	COG0840	transmembrane signaling receptor activity
LC20_RS09100	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
LC20_RS09110	COG0745	RESPONSE REGULATOR receiver
LC20_RS09115	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
LC20_RS09120	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
LC20_RS09125	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
LC20_RS09135	COG3418	PFAM FlgN family protein
LC20_RS09140	COG2747	anti-sigma28 factor FlgM
LC20_RS09150	COG1815	bacterial-type flagellum-dependent cell motility
LC20_RS09155	COG1558	bacterial-type flagellum-dependent cell motility
LC20_RS09160	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
LC20_RS09165	COG1749	Flagellar hook protein flgE
LC20_RS09195	COG1256	bacterial-type flagellum assembly
LC20_RS09200	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
LC20_RS09215	COG1338	Plays a role in the flagellum-specific transport system
LC20_RS09235	COG1580	Controls the rotational direction of flagella during chemotaxis
LC20_RS09245	COG2882	bacterial-type flagellum organization
LC20_RS09250	COG1157	protein secretion by the type III secretion system
LC20_RS09255	COG1317	bacterial-type flagellum organization
LC20_RS09270	COG1677	Flagellar hook-basal body complex protein FliE
LC20_RS09295	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
LC20_RS09325	COG1191	sigma factor activity
LC20_RS09335	COG2515	1-aminocyclopropane-1-carboxylate deaminase
LC20_RS09340	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LC20_RS09345	COG0765	amino acid transport
LC20_RS09350	COG1126	abc transporter atp-binding protein
LC20_RS09365	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
LC20_RS09365	COG0506	proline dehydrogenase activity
LC20_RS09365	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
LC20_RS09375	COG0672	)-iron permease
LC20_RS09380	COG2822	iron ion transport
LC20_RS09415	COG1881	PFAM PEBP family protein
LC20_RS09425	COG1113	amino acid transport
LC20_RS09450	COG2226	methyltransferase
LC20_RS09465	COG0366	Alpha amylase catalytic
LC20_RS09475	COG3136	membrane protein required for alginate biosynthesis
LC20_RS09485	COG2197	response regulator
LC20_RS09490	COG0322	excinuclease ABC activity
LC20_RS09495	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LC20_RS09575	COG0305	Participates in initiation and elongation during chromosome replication
LC20_RS09620	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LC20_RS09635	COG3772	lysozyme
LC20_RS09660	COG3328	transposase activity
LC20_RS09670	COG3328	transposase activity
LC20_RS09730	COG0456	acetyltransferase
LC20_RS09745	COG3122	Protein conserved in bacteria
LC20_RS09755	COG0561	phosphatase activity
LC20_RS09760	COG2223	nitrite transmembrane transporter activity
LC20_RS09770	COG0346	lactoylglutathione lyase activity
LC20_RS09785	COG3493	citrate carrier protein
LC20_RS09790	COG4565	transcriptional regulatory protein
LC20_RS09795	COG3290	protein histidine kinase activity
LC20_RS09800	COG1349	DNA-binding transcription factor activity
LC20_RS09805	COG3395	kinase activity
LC20_RS09810	COG0235	Class ii aldolase
LC20_RS09815	COG3622	Belongs to the hyi family
LC20_RS09820	COG2066	Belongs to the glutaminase family
LC20_RS09840	COG0672	)-iron permease
LC20_RS09875	COG0006	proline dipeptidase activity
LC20_RS09880	COG0457	Tetratricopeptide repeat
LC20_RS09885	COG1649	PFAM Uncharacterised BCR, COG1649
LC20_RS09885	COG0726	polysaccharide deacetylase
LC20_RS09890	COG1215	transferase activity, transferring glycosyl groups
LC20_RS09895	COG3658	cytochrome
LC20_RS09905	COG1702	phosphate starvation-inducible protein PhoH
LC20_RS09910	COG0387	Pfam Sodium calcium exchanger
LC20_RS09920	COG0583	DNA-binding transcription factor activity
LC20_RS09925	COG3850	Histidine kinase
LC20_RS09935	COG1294	oxidase, subunit
LC20_RS09940	COG1271	oxidase subunit
LC20_RS09945	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LC20_RS09955	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LC20_RS09960	COG3138	arginine N-succinyltransferase
LC20_RS09970	COG3724	N-succinylarginine dihydrolase activity
LC20_RS09975	COG2988	succinylglutamate desuccinylase activity
LC20_RS09990	COG1228	amidohydrolase
LC20_RS10000	COG0402	S-adenosylhomocysteine deaminase activity
LC20_RS10020	COG4211	Belongs to the binding-protein-dependent transport system permease family
LC20_RS10025	COG3443	Belongs to the bacterial solute-binding protein 9 family
LC20_RS10035	COG4942	peptidase
LC20_RS10045	COG0191	fructose-bisphosphate aldolase activity
LC20_RS10050	COG2222	sugar isomerase
LC20_RS10055	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
LC20_RS10060	COG3716	PTS system mannose fructose sorbose family IID component
LC20_RS10070	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LC20_RS10080	COG1349	DNA-binding transcription factor activity
LC20_RS10105	COG0012	GTP binding
LC20_RS10115	COG0193	aminoacyl-tRNA hydrolase activity
LC20_RS10130	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LC20_RS10140	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
LC20_RS10145	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
LC20_RS10150	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
LC20_RS10155	COG2890	protein-(glutamine-N5) methyltransferase activity
LC20_RS10170	COG2877	3-deoxy-8-phosphooctulonate synthase activity
LC20_RS10175	COG0659	secondary active sulfate transmembrane transporter activity
LC20_RS10195	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LC20_RS10200	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
LC20_RS10205	COG3381	protein complex oligomerization
LC20_RS10215	COG0477	Major facilitator Superfamily
LC20_RS10220	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LC20_RS10230	COG0673	inositol 2-dehydrogenase activity
LC20_RS10235	COG0728	peptidoglycan biosynthetic process
LC20_RS10240	COG0018	arginyl-trna synthetase
LC20_RS10245	COG3102	Protein conserved in bacteria
LC20_RS10250	COG3142	Participates in the control of copper homeostasis
LC20_RS10255	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LC20_RS10265	COG3788	relative of glutathione S-transferase, MAPEG superfamily
LC20_RS10270	COG1801	Protein of unknown function DUF72
LC20_RS10275	COG1335	isochorismatase
LC20_RS10285	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
LC20_RS10290	COG0494	nUDIX hydrolase
LC20_RS10295	COG0217	transcriptional regulatory protein
LC20_RS10310	COG2255	four-way junction helicase activity
LC20_RS10315	COG3104	oligopeptide transport
LC20_RS10320	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LC20_RS10325	COG1121	(ABC) transporter
LC20_RS10330	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
LC20_RS10335	COG0739	heme binding
LC20_RS10340	COG1560	Kdo2-lipid A biosynthetic process
LC20_RS10345	COG0469	pyruvate kinase activity
LC20_RS10350	COG1737	Transcriptional regulator
LC20_RS10355	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
LC20_RS10360	COG0800	Aldolase
LC20_RS10365	COG2076	Multidrug Resistance protein
LC20_RS10370	COG2076	Multidrug Resistance protein
LC20_RS10375	COG0251	oxidation-reduction process
LC20_RS10380	COG1199	ATP-dependent helicase activity
LC20_RS10390	COG3065	identical protein binding
LC20_RS10395	COG0318	PFAM AMP-dependent synthetase and ligase
LC20_RS10400	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
LC20_RS10405	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
LC20_RS10410	COG2894	cell division
LC20_RS10415	COG0850	regulation of cytokinetic process
LC20_RS10430	COG2951	lytic endotransglycosylase activity
LC20_RS10435	COG0179	Fumarylacetoacetate (FAA) hydrolase
LC20_RS10440	COG2983	Belongs to the UPF0260 family
LC20_RS10465	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
LC20_RS10475	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
LC20_RS10480	COG2186	Transcriptional regulator
LC20_RS10485	COG2719	SpoVR family
LC20_RS10490	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LC20_RS10495	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LC20_RS10500	COG2814	Major facilitator Superfamily
LC20_RS10505	COG2199	diguanylate cyclase activity
LC20_RS10505	COG2202	Pas domain
LC20_RS10505	COG2200	EAL domain
LC20_RS10515	COG0583	DNA-binding transcription factor activity
LC20_RS10535	COG2766	serine protein kinase
LC20_RS10545	COG3713	MltA-interacting MipA family protein
LC20_RS10565	COG3139	Protein of unknown function (DUF1315)
LC20_RS10575	COG0252	asparaginase activity
LC20_RS10580	COG0616	signal peptide processing
LC20_RS10585	COG0778	Nitroreductase
LC20_RS10595	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LC20_RS10605	COG0494	nUDIX hydrolase
LC20_RS10610	COG0708	Exodeoxyribonuclease III
LC20_RS10615	COG0583	DNA-binding transcription factor activity
LC20_RS10630	COG0788	formyltetrahydrofolate deformylase activity
LC20_RS10635	COG3012	SEC-C Motif Domain Protein
LC20_RS10640	COG1752	Esterase of the alpha-beta hydrolase superfamily
LC20_RS10645	COG0745	RESPONSE REGULATOR receiver
LC20_RS10655	COG2916	Histone family protein nucleoid-structuring protein H-NS
LC20_RS10670	COG1454	alcohol dehydrogenase
LC20_RS10670	COG1012	belongs to the aldehyde dehydrogenase family
LC20_RS10680	COG2095	MarC family integral membrane protein
LC20_RS10700	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LC20_RS10705	COG0444	Belongs to the ABC transporter superfamily
LC20_RS10710	COG4608	Belongs to the ABC transporter superfamily
LC20_RS10720	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LC20_RS10745	COG2350	Protein conserved in bacteria
LC20_RS10750	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
LC20_RS10760	COG2917	probably involved in intracellular septation
LC20_RS10775	COG0727	PFAM Uncharacterised protein family (UPF0153)
LC20_RS10780	COG3047	cAMP biosynthetic process
LC20_RS10790	COG0159	tryptophan synthase activity
LC20_RS10795	COG0133	tryptophan synthase activity
LC20_RS10800	COG0135	phosphoribosylanthranilate isomerase activity
LC20_RS10800	COG0134	indole-3-glycerol-phosphate synthase activity
LC20_RS10810	COG0512	Glutamine amidotransferase of anthranilate synthase
LC20_RS10825	COG0613	PHP domain protein
LC20_RS10830	COG0009	L-threonylcarbamoyladenylate synthase
LC20_RS10850	COG1388	LysM domain
LC20_RS10850	COG4932	domain protein
LC20_RS10850	COG2373	Large extracellular alpha-helical protein
LC20_RS10920	COG1187	pseudouridine synthase activity
LC20_RS10925	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
LC20_RS10930	COG1028	Short-chain dehydrogenase reductase Sdr
LC20_RS10935	COG0616	signal peptide processing
LC20_RS10955	COG0583	DNA-binding transcription factor activity
LC20_RS10995	COG0671	phosphoesterase, PA-phosphatase related
LC20_RS11000	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
LC20_RS11005	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
LC20_RS11020	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LC20_RS11030	COG0673	inositol 2-dehydrogenase activity
LC20_RS11040	COG2072	flavoprotein involved in K transport
LC20_RS11070	COG1396	sequence-specific DNA binding
LC20_RS11075	COG3135	benzoate transporter
LC20_RS11085	COG0284	orotidine-5'-phosphate decarboxylase activity
LC20_RS11090	COG0023	Translation Initiation Factor
LC20_RS11105	COG0235	Class ii aldolase
LC20_RS11115	COG1349	DNA-binding transcription factor activity
LC20_RS11120	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LC20_RS11125	COG2879	small protein
LC20_RS11130	COG1966	Carbon starvation protein
LC20_RS11140	COG0243	molybdopterin cofactor binding
LC20_RS11150	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
LC20_RS11160	COG4659	FMN binding
LC20_RS11165	COG4658	electron transport chain
LC20_RS11170	COG3708	Transcriptional regulator
LC20_RS11170	COG2207	Transcriptional regulator
LC20_RS11175	COG4656	Part of a membrane complex involved in electron transport
LC20_RS11185	COG4657	Part of a membrane complex involved in electron transport
LC20_RS11195	COG2759	Belongs to the formate--tetrahydrofolate ligase family
LC20_RS11215	COG2274	protein secretion by the type I secretion system
LC20_RS11225	COG2160	L-arabinose isomerase activity
LC20_RS11235	COG1879	ABC-type sugar transport system periplasmic component
LC20_RS11240	COG1129	ABC transporter
LC20_RS11245	COG1172	Belongs to the binding-protein-dependent transport system permease family
LC20_RS11255	COG0673	inositol 2-dehydrogenase activity
LC20_RS11260	COG0385	Bile acid
LC20_RS11265	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
LC20_RS11270	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
LC20_RS11275	COG1263	PTS System
LC20_RS11275	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LC20_RS11280	COG1609	Transcriptional regulator
LC20_RS11285	COG5339	Protein conserved in bacteria
LC20_RS11295	COG0114	fumarate hydratase activity
LC20_RS11300	COG2020	methyltransferase activity
LC20_RS11325	COG3121	Chaperone
LC20_RS11330	COG3121	Chaperone
LC20_RS11335	COG3539	Fimbrial protein
LC20_RS11340	COG3121	Chaperone
LC20_RS11360	COG2814	Major facilitator Superfamily
LC20_RS11365	COG0583	DNA-binding transcription factor activity
LC20_RS11370	COG1940	carbohydrate kinase activity
LC20_RS11375	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
LC20_RS11400	COG1742	UPF0060 membrane protein
LC20_RS11405	COG4221	oxidoreductase activity
LC20_RS11410	COG0477	Major facilitator Superfamily
LC20_RS11440	COG0625	glutathione transferase activity
LC20_RS11450	COG1522	sequence-specific DNA binding
LC20_RS11490	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
LC20_RS11515	COG2197	response regulator
LC20_RS11525	COG3710	Transcriptional regulator
LC20_RS11530	COG3210	domain, Protein
LC20_RS11530	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
LC20_RS11530	COG3064	Membrane
LC20_RS11530	COG3064	Membrane
LC20_RS11530	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
LC20_RS11530	COG3210	domain, Protein
LC20_RS11535	COG2831	hemolysin activation secretion protein
LC20_RS11545	COG3188	usher protein
LC20_RS11550	COG3121	Chaperone
LC20_RS11570	COG0028	Belongs to the TPP enzyme family
LC20_RS11575	COG0440	acetolactate synthase activity
LC20_RS11585	COG1011	Hydrolase
LC20_RS11595	COG0583	DNA-binding transcription factor activity
LC20_RS11615	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LC20_RS11625	COG1028	Short-chain dehydrogenase reductase Sdr
LC20_RS11635	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
LC20_RS11650	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LC20_RS11655	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LC20_RS11660	COG0589	response to stress
LC20_RS11665	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
LC20_RS11675	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
LC20_RS11690	COG0531	amino acid
LC20_RS11700	COG0745	RESPONSE REGULATOR receiver
LC20_RS11705	COG2205	protein histidine kinase activity
LC20_RS11710	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
LC20_RS11720	COG3591	Belongs to the peptidase S1B family
LC20_RS11730	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
LC20_RS11735	COG1643	Atp-dependent helicase
LC20_RS11740	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
LC20_RS11745	COG2390	Transcriptional regulator
LC20_RS11750	COG0246	Mannitol dehydrogenase
LC20_RS11755	COG1070	Carbohydrate kinase
LC20_RS11765	COG3784	Protein of unknown function (DUF1318)
LC20_RS11775	COG2911	Protein conserved in bacteria
LC20_RS11780	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LC20_RS11785	COG3042	response to heat
LC20_RS11790	COG1285	pathogenesis
LC20_RS11815	COG0037	tRNA processing
LC20_RS11835	COG4166	transmembrane transport
LC20_RS11840	COG2866	Carboxypeptidase
LC20_RS11845	COG4948	Mandelate Racemase Muconate Lactonizing
LC20_RS11850	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
LC20_RS11860	COG5642	Protein of unknown function (DUF2384)
LC20_RS11865	COG5654	RES domain protein
LC20_RS11870	COG3768	UPF0283 membrane protein
LC20_RS11875	COG3106	COG3106 Predicted ATPase
LC20_RS11885	COG1983	PspC domain protein
LC20_RS11895	COG1842	Phage shock protein A
LC20_RS11900	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
LC20_RS11920	COG4171	peptide transport system, permease
LC20_RS11930	COG4172	Belongs to the ABC transporter superfamily
LC20_RS11975	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LC20_RS11975	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LC20_RS12005	COG0625	glutathione transferase activity
LC20_RS12015	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
LC20_RS12020	COG0259	pyridoxamine-phosphate oxidase activity
LC20_RS12025	COG3895	Periplasmic Protein
LC20_RS12030	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
LC20_RS12035	COG3133	Outer membrane lipoprotein
LC20_RS12040	COG1846	Transcriptional regulator
LC20_RS12050	COG1566	PFAM secretion protein HlyD family protein
LC20_RS12060	COG4989	oxidoreductase activity
LC20_RS12065	COG3313	Fe-S protein
LC20_RS12070	COG2194	sulfuric ester hydrolase activity
LC20_RS12075	COG1309	transcriptional regulator
LC20_RS12080	COG1902	pentaerythritol trinitrate reductase activity
LC20_RS12085	COG0346	lactoylglutathione lyase activity
LC20_RS12090	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LC20_RS12095	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
LC20_RS12100	COG0791	NLP P60 protein
LC20_RS12115	COG1609	Transcriptional regulator
LC20_RS12120	COG0583	DNA-binding transcription factor activity
LC20_RS12125	COG2814	Major facilitator Superfamily
LC20_RS12130	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LC20_RS12135	COG0307	riboflavin synthase, alpha
LC20_RS12140	COG0534	Mate efflux family protein
LC20_RS12170	COG1388	LysM domain
LC20_RS12170	COG1376	ErfK ybiS ycfS ynhG family protein
LC20_RS12175	COG2166	iron-sulfur cluster assembly
LC20_RS12185	COG0719	Fe-S assembly protein
LC20_RS12190	COG0396	ATPase activity
LC20_RS12195	COG0719	Fe-S assembly protein
LC20_RS12200	COG0316	Belongs to the HesB IscA family
LC20_RS12210	COG2050	protein possibly involved in aromatic compounds catabolism
LC20_RS12215	COG0247	lactate metabolic process
LC20_RS12215	COG0277	FAD linked oxidase domain protein
LC20_RS12220	COG0628	permease
LC20_RS12230	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LC20_RS12230	COG0574	Belongs to the PEP-utilizing enzyme family
LC20_RS12235	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
LC20_RS12250	COG4771	TonB-dependent receptor
LC20_RS12255	COG3720	iron ion transport
LC20_RS12260	COG4558	Periplasmic binding protein
LC20_RS12270	COG0095	Lipoate-protein ligase
LC20_RS12275	COG0791	NLP P60 protein
LC20_RS12280	COG2076	Multidrug Resistance protein
LC20_RS12285	COG2076	Multidrug Resistance protein
LC20_RS12290	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
LC20_RS12295	COG0726	polysaccharide deacetylase
LC20_RS12305	COG0463	Glycosyl transferase, family 2
LC20_RS12310	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LC20_RS12315	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
LC20_RS12320	COG0386	Belongs to the glutathione peroxidase family
LC20_RS12335	COG2314	TM2 domain
LC20_RS12340	COG0776	regulation of translation
LC20_RS12355	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
LC20_RS12365	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
LC20_RS12370	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
LC20_RS12375	COG4249	Peptidase C14 caspase catalytic subunit p20
LC20_RS12380	COG1811	Na channel or pump
LC20_RS12415	COG0803	Belongs to the bacterial solute-binding protein 9 family
LC20_RS12420	COG1121	(ABC) transporter
LC20_RS12425	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LC20_RS12430	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LC20_RS12435	COG3001	Fructosamine kinase
LC20_RS12440	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LC20_RS12440	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LC20_RS12445	COG1703	isobutyryl-CoA mutase activity
LC20_RS12450	COG1024	Enoyl-CoA hydratase
LC20_RS12455	COG0427	acetyl-CoA hydrolase
LC20_RS12460	COG0583	DNA-binding transcription factor activity
LC20_RS12475	COG1917	Cupin 2, conserved barrel domain protein
LC20_RS12480	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
LC20_RS12485	COG1028	Short-chain dehydrogenase reductase Sdr
LC20_RS12495	COG1175	transmembrane transport
LC20_RS12500	COG0395	ABC-type sugar transport system, permease component
LC20_RS12505	COG3842	ATPase activity
LC20_RS12515	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
LC20_RS12520	COG1988	membrane-bound metal-dependent
LC20_RS12525	COG1823	symporter activity
LC20_RS12530	COG3023	N-Acetylmuramoyl-L-alanine amidase
LC20_RS12540	COG0823	Involved in the tonB-independent uptake of proteins
LC20_RS12545	COG2814	Major facilitator Superfamily
LC20_RS12550	COG0501	Belongs to the peptidase M48B family
LC20_RS12555	COG0793	Belongs to the peptidase S41A family
LC20_RS12565	COG1956	GAF domain-containing protein
LC20_RS12570	COG2995	paraquat-inducible protein a
LC20_RS12575	COG3008	intermembrane lipid transfer
LC20_RS12585	COG2814	Major facilitator Superfamily
LC20_RS12620	COG3706	GGDEF domain
LC20_RS12620	COG2203	Gaf domain
LC20_RS12620	COG5001	Diguanylate cyclase
LC20_RS12620	COG4251	negative regulation of phosphorylation
LC20_RS12650	COG0625	glutathione transferase activity
LC20_RS12670	COG0786	glutamate:sodium symporter activity
LC20_RS12675	COG1187	pseudouridine synthase activity
LC20_RS12695	COG3328	transposase activity
LC20_RS12820	COG3566	protein conserved in bacteria
LC20_RS12830	COG3567	Phage-associated protein, HI1409 family
LC20_RS12840	COG3077	Addiction module antitoxin, RelB DinJ family
LC20_RS12845	COG2026	Addiction module toxin, RelE StbE family
LC20_RS12870	COG1475	DNA binding
LC20_RS12885	COG3772	lysozyme
LC20_RS12975	COG1396	sequence-specific DNA binding
LC20_RS13015	COG0582	viral genome integration into host DNA
LC20_RS13020	COG3328	transposase activity
LC20_RS13030	COG1276	copper resistance
LC20_RS13035	COG2372	response to copper ion
LC20_RS13040	COG1528	Iron-storage protein
LC20_RS13060	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LC20_RS13065	COG1770	oligopeptidase
LC20_RS13075	COG3097	Belongs to the UPF0267 family
LC20_RS13080	COG3141	response to X-ray
LC20_RS13085	COG0513	Belongs to the DEAD box helicase family
LC20_RS13090	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
LC20_RS13095	COG3140	Belongs to the UPF0181 family
LC20_RS13105	COG0494	nUDIX hydrolase
LC20_RS13110	COG1760	l-serine dehydratase
LC20_RS13120	COG1253	flavin adenine dinucleotide binding
LC20_RS13125	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LC20_RS13125	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
LC20_RS13130	COG3715	PTS system
LC20_RS13135	COG3716	PTS system mannose fructose sorbose family IID component
LC20_RS13140	COG4811	Protein of unknown function (DUF986)
LC20_RS13145	COG1971	Probably functions as a manganese efflux pump
LC20_RS13160	COG3447	MASE1 domain protein
LC20_RS13160	COG5002	protein histidine kinase activity
LC20_RS13160	COG5001	Diguanylate cyclase
LC20_RS13170	COG2226	methyltransferase
LC20_RS13175	COG0768	penicillin binding
LC20_RS13180	COG1496	oxidoreductase activity
LC20_RS13200	COG1113	amino acid transport
LC20_RS13235	COG2207	Transcriptional regulator
LC20_RS13255	COG1132	(ABC) transporter
LC20_RS13265	COG3706	GGDEF domain
LC20_RS13265	COG2203	Gaf domain
LC20_RS13265	COG4251	negative regulation of phosphorylation
LC20_RS13265	COG5001	Diguanylate cyclase
LC20_RS13280	COG3755	Protein conserved in bacteria
LC20_RS13290	COG0697	spore germination
LC20_RS13295	COG2271	Major facilitator Superfamily
LC20_RS13300	COG4948	Mandelate Racemase Muconate Lactonizing
LC20_RS13305	COG1802	Transcriptional regulator
LC20_RS13310	COG1063	alcohol dehydrogenase
LC20_RS13315	COG0246	Mannitol dehydrogenase
LC20_RS13320	COG2721	sulfolactate sulfo-lyase activity
LC20_RS13335	COG1733	regulation of RNA biosynthetic process
LC20_RS13340	COG0702	epimerase
LC20_RS13345	COG2873	o-acetylhomoserine
LC20_RS13365	COG0840	transmembrane signaling receptor activity
LC20_RS13405	COG2755	lipolytic protein G-D-S-L family
LC20_RS13405	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
LC20_RS13415	COG3039	Transposase
LC20_RS13420	COG2755	lipolytic protein G-D-S-L family
LC20_RS13420	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
LC20_RS13480	COG1388	LysM domain
LC20_RS13480	COG1470	cell adhesion involved in biofilm formation
LC20_RS13615	COG3566	protein conserved in bacteria
LC20_RS13625	COG3567	Phage-associated protein, HI1409 family
LC20_RS13635	COG3077	Addiction module antitoxin, RelB DinJ family
LC20_RS13640	COG2026	Addiction module toxin, RelE StbE family
LC20_RS13665	COG1475	DNA binding
LC20_RS13680	COG3772	lysozyme
LC20_RS13825	COG0582	viral genome integration into host DNA
LC20_RS13830	COG0538	isocitrate dehydrogenase activity
LC20_RS13835	COG1187	pseudouridine synthase activity
LC20_RS13845	COG0482	sulfurtransferase activity
LC20_RS13850	COG2915	High frequency lysogenization protein hflD homolog
LC20_RS13855	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
LC20_RS13865	COG0745	RESPONSE REGULATOR receiver
LC20_RS13875	COG2850	peptidyl-arginine hydroxylation
LC20_RS13890	COG1940	carbohydrate kinase activity
LC20_RS13895	COG4591	ABC-type transport system involved in lipoprotein release permease component
LC20_RS13905	COG4591	ABC-type transport system involved in lipoprotein release permease component
LC20_RS13910	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
LC20_RS13915	COG3134	Outer membrane lipoprotein
LC20_RS13920	COG1252	NADH dehydrogenase
LC20_RS13925	COG3150	esterase
LC20_RS13930	COG1472	Belongs to the glycosyl hydrolase 3 family
LC20_RS13935	COG0510	thiamine kinase activity
LC20_RS13940	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
LC20_RS13945	COG5633	Lipoprotein
LC20_RS13950	COG0537	adenosine 5'-monophosphoramidase activity
LC20_RS13955	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LC20_RS13965	COG1263	PTS System
LC20_RS13965	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LC20_RS13970	COG0084	hydrolase, TatD family'
LC20_RS13975	COG0470	DNA polymerase III
LC20_RS13980	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
LC20_RS13985	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
LC20_RS13990	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LC20_RS13995	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LC20_RS14010	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
LC20_RS14020	COG0416	fatty acid biosynthetic process
LC20_RS14025	COG0333	Belongs to the bacterial ribosomal protein bL32 family
LC20_RS14030	COG1399	metal-binding, possibly nucleic acid-binding protein
LC20_RS14035	COG0424	maF-like protein
LC20_RS14040	COG0564	pseudouridine synthase activity
LC20_RS14050	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
LC20_RS14055	COG0418	dihydroorotase activity
LC20_RS14085	COG0628	permease
LC20_RS14110	COG1560	Kdo2-lipid A biosynthetic process
LC20_RS14115	COG2259	Doxx family
LC20_RS14120	COG2814	Major facilitator Superfamily
LC20_RS14135	COG5645	(Lipo)protein
LC20_RS14140	COG2943	transferase activity, transferring hexosyl groups
LC20_RS14145	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
LC20_RS14160	COG3263	regulation of cellular component size
LC20_RS14170	COG3916	Acyl-homoserine-lactone synthase
LC20_RS14175	COG2771	luxR family
LC20_RS14185	COG2920	part of a sulfur-relay system
LC20_RS14190	COG1254	Belongs to the acylphosphatase family
LC20_RS14205	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
LC20_RS14210	COG3785	DNA binding
LC20_RS14215	COG1832	CoA-binding protein
LC20_RS14225	COG1803	Methylglyoxal synthase
LC20_RS14230	COG0210	DNA helicase
LC20_RS14235	COG3304	Inner membrane component domain
LC20_RS14240	COG1289	transmembrane transporter activity
LC20_RS14245	COG3070	regulator of competence-specific genes
LC20_RS14250	COG5404	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
LC20_RS14260	COG3120	sequence-specific DNA binding
LC20_RS14265	COG1067	ATP-dependent peptidase activity
LC20_RS14270	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LC20_RS14280	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LC20_RS14285	COG3130	regulation of translation
LC20_RS14290	COG3009	Protein conserved in bacteria
LC20_RS14295	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
LC20_RS14295	COG3008	intermembrane lipid transfer
LC20_RS14300	COG2995	paraquat-inducible protein a
LC20_RS14305	COG0488	(ABC) transporter
LC20_RS14310	COG0116	Belongs to the methyltransferase superfamily
LC20_RS14310	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
LC20_RS14315	COG0633	Ferredoxin
LC20_RS14315	COG3217	Mosc domain protein beta barrel domain protein
LC20_RS14325	COG0167	dihydroorotate dehydrogenase activity
LC20_RS14330	COG0308	aminopeptidase N
LC20_RS14375	COG1388	LysM domain
LC20_RS14375	COG2373	Large extracellular alpha-helical protein
LC20_RS14375	COG4932	domain protein
LC20_RS14390	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
LC20_RS14415	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
LC20_RS14440	COG0017	Asparaginyl-tRNA synthetase
LC20_RS14450	COG1448	Aminotransferase
LC20_RS14455	COG2200	EAL domain
LC20_RS14460	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LC20_RS14465	COG3108	Peptidase M15
LC20_RS14470	COG2989	Protein conserved in bacteria
LC20_RS14475	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
LC20_RS14485	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
LC20_RS14490	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LC20_RS14495	COG1434	Gram-negative-bacterium-type cell wall biogenesis
LC20_RS14500	COG3173	Aminoglycoside phosphotransferase
LC20_RS14505	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
LC20_RS14510	COG2835	tetraacyldisaccharide 4'-kinase activity
LC20_RS14525	COG5383	Protein conserved in bacteria
LC20_RS14530	COG1663	tetraacyldisaccharide 4'-kinase activity
LC20_RS14540	COG2333	competence protein COMEC
LC20_RS14540	COG0658	competence protein
LC20_RS14545	COG0776	regulation of translation
LC20_RS14550	COG0539	negative regulation of cytoplasmic translation
LC20_RS14555	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
LC20_RS14560	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
LC20_RS14570	COG0252	asparaginase activity
LC20_RS14575	COG1944	ATP diphosphatase activity
LC20_RS14580	COG2116	formate transmembrane transporter activity
LC20_RS14585	COG1882	Formate acetyltransferase
LC20_RS14590	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
LC20_RS14595	COG2814	Major facilitator Superfamily
LC20_RS14600	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
LC20_RS14615	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
LC20_RS14620	COG3107	peptidoglycan biosynthetic process
LC20_RS14620	COG1674	ftsk spoiiie
LC20_RS14630	COG0492	ferredoxin-NADP+ reductase activity
LC20_RS14640	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
LC20_RS14645	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
LC20_RS14650	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
LC20_RS14655	COG0542	response to heat
LC20_RS14660	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
LC20_RS14665	COG1278	Cold shock
LC20_RS14675	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LC20_RS14680	COG2990	Protein conserved in bacteria
LC20_RS14685	COG3593	DNA synthesis involved in DNA repair
LC20_RS14690	COG2431	L-lysine efflux transmembrane transporter activity
LC20_RS14695	COG1151	hydroxylamine reductase activity
LC20_RS14700	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LC20_RS14705	COG0028	Belongs to the TPP enzyme family
LC20_RS14715	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
LC20_RS14720	COG0702	epimerase
LC20_RS14725	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LC20_RS14740	COG1126	abc transporter atp-binding protein
LC20_RS14745	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LC20_RS14750	COG4215	(ABC) transporter
LC20_RS14755	COG4160	amino acid transport
LC20_RS14765	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LC20_RS14770	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LC20_RS14780	COG1177	transmembrane transport
LC20_RS14785	COG1176	ABC-type spermidine putrescine transport system, permease component I
LC20_RS14790	COG3842	ATPase activity
LC20_RS14795	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
LC20_RS14815	COG0569	domain protein
LC20_RS14815	COG2985	domain, Protein
LC20_RS14830	COG0671	phosphoesterase, PA-phosphatase related
LC20_RS14835	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
LC20_RS14840	COG1349	DNA-binding transcription factor activity
LC20_RS14845	COG0814	amino acid
LC20_RS14850	COG1760	l-serine dehydratase
LC20_RS14855	COG1686	Belongs to the peptidase S11 family
LC20_RS14865	COG0626	cystathionine gamma-synthase activity
LC20_RS14870	COG2011	ABC-type metal ion transport system permease component
LC20_RS14900	COG0625	glutathione transferase activity
LC20_RS14905	COG4771	TonB-dependent receptor
LC20_RS14915	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LC20_RS14920	COG0833	amino acid
LC20_RS14925	COG0583	DNA-binding transcription factor activity
LC20_RS14935	COG2855	membrane
LC20_RS14940	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
LC20_RS14945	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
LC20_RS14945	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LC20_RS14945	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LC20_RS14950	COG1105	Belongs to the carbohydrate kinase PfkB family
LC20_RS14975	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LC20_RS14990	COG0246	Mannitol dehydrogenase
LC20_RS14995	COG2186	Transcriptional regulator
LC20_RS15005	COG0523	cobalamin synthesis protein
LC20_RS15010	COG0671	phosphoesterase, PA-phosphatase related
LC20_RS15015	COG0791	NLP P60 protein
LC20_RS15025	COG2200	EAL domain
LC20_RS15030	COG4166	transmembrane transport
LC20_RS15035	COG4174	ABC transporter (Permease)
LC20_RS15040	COG4239	(ABC) transporter, permease
LC20_RS15045	COG4172	Belongs to the ABC transporter superfamily
LC20_RS15055	COG2814	Major facilitator Superfamily
LC20_RS15060	COG1187	pseudouridine synthase activity
LC20_RS15065	COG1061	Type III restriction enzyme res subunit
LC20_RS15075	COG3081	Nucleoid-associated protein
LC20_RS15080	COG3082	Protein of unknown function (DUF1414)
LC20_RS15105	COG2723	6-phospho-beta-galactosidase activity
LC20_RS15110	COG1263	PTS System
LC20_RS15110	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LC20_RS15110	COG2190	(PTS) system
LC20_RS15140	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LC20_RS15155	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
LC20_RS15165	COG2223	nitrite transmembrane transporter activity
LC20_RS15170	COG0642	Histidine kinase
LC20_RS15170	COG2198	Histidine kinase
LC20_RS15185	COG3328	transposase activity
LC20_RS15200	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LC20_RS15205	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LC20_RS15215	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LC20_RS15220	COG4574	serine-type endopeptidase inhibitor activity
LC20_RS15230	COG0814	amino acid
LC20_RS15250	COG1441	menaquinone biosynthetic process
LC20_RS15255	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
LC20_RS15260	COG0596	Alpha beta hydrolase
LC20_RS15265	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
LC20_RS15270	COG1169	isochorismate synthase
LC20_RS15275	COG4575	ribosome binding
LC20_RS15285	COG4702	Belongs to the UPF0303 family
LC20_RS15295	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LC20_RS15305	COG1028	Short-chain dehydrogenase reductase Sdr
LC20_RS15310	COG3265	gluconokinase activity
LC20_RS15335	COG1007	ATP synthesis coupled electron transport
LC20_RS15340	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LC20_RS15345	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LC20_RS15350	COG0713	ATP synthesis coupled electron transport
LC20_RS15355	COG0839	Belongs to the complex I subunit 6 family
LC20_RS15360	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LC20_RS15365	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
LC20_RS15370	COG1034	ATP synthesis coupled electron transport
LC20_RS15385	COG0649	NAD binding
LC20_RS15385	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LC20_RS15390	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LC20_RS15395	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LC20_RS15400	COG0583	DNA-binding transcription factor activity
LC20_RS15410	COG0436	Aminotransferase
LC20_RS15415	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
LC20_RS15425	COG0490	domain, Protein
LC20_RS15425	COG0471	metal ion transport
LC20_RS15435	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LC20_RS15440	COG3013	Belongs to the UPF0304 family
LC20_RS15445	COG3092	negative regulation of chromosome organization
LC20_RS15455	COG0857	belongs to the CobB CobQ family
LC20_RS15455	COG0280	phosphate acetyltransferase
LC20_RS15460	COG1609	Transcriptional regulator
LC20_RS15465	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LC20_RS15475	COG3037	sugar-specific permease SgaT UlaA
LC20_RS15480	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
LC20_RS15485	COG0622	Phosphoesterase
LC20_RS15495	COG1090	epimerase
LC20_RS15500	COG4598	ABC transporter
LC20_RS15505	COG4160	amino acid transport
LC20_RS15510	COG4215	(ABC) transporter
LC20_RS15515	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LC20_RS15530	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
LC20_RS15535	COG1286	toxin biosynthetic process
LC20_RS15540	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
LC20_RS15545	COG0285	dihydrofolate synthase activity
LC20_RS15550	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
LC20_RS15555	COG0586	Pfam SNARE associated Golgi protein
LC20_RS15565	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LC20_RS15570	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LC20_RS15580	COG0697	spore germination
LC20_RS15590	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LC20_RS15595	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LC20_RS15620	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
LC20_RS15640	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LC20_RS15645	COG2723	6-phospho-beta-galactosidase activity
LC20_RS15650	COG1447	Phosphotransferase system cellobiose-specific component IIA
LC20_RS15660	COG1794	racemase activity, acting on amino acids and derivatives
LC20_RS15665	COG3328	transposase activity
LC20_RS15675	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LC20_RS15680	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LC20_RS15680	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
LC20_RS15690	COG3101	peptidyl-lysine hydroxylation
LC20_RS15695	COG0730	response to heat
LC20_RS15700	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
LC20_RS15705	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
LC20_RS15710	COG2890	protein-(glutamine-N5) methyltransferase activity
LC20_RS15715	COG2840	Smr protein MutS2
LC20_RS15720	COG2062	phosphohistidine phosphatase, SixA
LC20_RS15725	COG1250	3-hydroxyacyl-CoA dehydrogenase
LC20_RS15725	COG1024	Enoyl-CoA hydratase
LC20_RS15730	COG0183	Belongs to the thiolase family
LC20_RS15735	COG3691	Protein conserved in bacteria
LC20_RS15750	COG4235	cytochrome complex assembly
LC20_RS15750	COG3088	subunit of a heme lyase
LC20_RS15765	COG1138	Cytochrome C-type biogenesis protein
LC20_RS15770	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
LC20_RS15775	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LC20_RS15780	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LC20_RS15785	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LC20_RS15820	COG3539	Fimbrial protein
LC20_RS15825	COG2824	Alkylphosphonate utilization operon protein PhnA
LC20_RS15835	COG1695	Transcriptional regulator
LC20_RS15845	COG2723	6-phospho-beta-galactosidase activity
LC20_RS15850	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LC20_RS15850	COG1263	PTS System
LC20_RS15855	COG1609	Transcriptional regulator
LC20_RS15860	COG2353	YceI-like domain
LC20_RS15865	COG3038	cytochrome b561
LC20_RS15870	COG1902	pentaerythritol trinitrate reductase activity
LC20_RS15885	COG1127	ABC transporter
LC20_RS15890	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LC20_RS15910	COG0531	amino acid
LC20_RS15915	COG2951	lytic endotransglycosylase activity
LC20_RS15935	COG1280	lysine exporter protein (LysE YggA)
LC20_RS15950	COG2723	6-phospho-beta-galactosidase activity
LC20_RS15965	COG0243	molybdopterin cofactor binding
LC20_RS15970	COG0437	4 iron, 4 sulfur cluster binding
LC20_RS15975	COG3302	dmso reductase anchor subunit
LC20_RS15980	COG3381	protein complex oligomerization
LC20_RS15990	COG1598	PFAM Uncharacterised protein family UPF0150
LC20_RS16000	COG3038	cytochrome b561
LC20_RS16005	COG0436	Aminotransferase
LC20_RS16020	COG3275	phosphorelay sensor kinase activity
LC20_RS16025	COG3279	Response regulator of the LytR AlgR family
LC20_RS16030	COG2223	nitrite transmembrane transporter activity
LC20_RS16055	COG0667	Aldo Keto reductase
LC20_RS16065	COG1914	H( )-stimulated, divalent metal cation uptake system
LC20_RS16070	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LC20_RS16100	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LC20_RS16130	COG3530	Putative quorum-sensing-regulated virulence factor
LC20_RS16170	COG3778	Protein conserved in bacteria
LC20_RS16175	COG3299	homolog of phage Mu protein gp47
LC20_RS16220	COG4386	tail sheath protein
LC20_RS16265	COG4695	Portal protein
LC20_RS16275	COG1802	Transcriptional regulator
LC20_RS16275	COG4626	Terminase
LC20_RS16295	COG3179	chitinase
LC20_RS16330	COG1403	HNH endonuclease
LC20_RS16355	COG4725	Belongs to the MT-A70-like family
LC20_RS16365	COG4626	Terminase
LC20_RS16365	COG1802	Transcriptional regulator
LC20_RS16420	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
LC20_RS16450	COG0582	viral genome integration into host DNA
LC20_RS16460	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LC20_RS16465	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LC20_RS16475	COG2205	protein histidine kinase activity
LC20_RS16480	COG0745	RESPONSE REGULATOR receiver
LC20_RS16485	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LC20_RS16505	COG4208	sulfate ABC transporter
LC20_RS16510	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
LC20_RS16525	COG1737	Transcriptional regulator
LC20_RS16530	COG2731	YhcH YjgK YiaL family protein
LC20_RS16545	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LC20_RS16550	COG2837	iron assimilation
LC20_RS16560	COG3111	PFAM Bacterial OB fold (BOF) protein
LC20_RS16565	COG1028	Short-chain dehydrogenase reductase Sdr
LC20_RS16570	COG2897	thiosulfate sulfurtransferase activity
LC20_RS16590	COG1172	Belongs to the binding-protein-dependent transport system permease family
LC20_RS16595	COG1129	ABC transporter
LC20_RS16605	COG0456	acetyltransferase
LC20_RS16610	COG0408	coproporphyrinogen oxidase activity
LC20_RS16625	COG0494	nUDIX hydrolase
LC20_RS16630	COG3005	denitrification pathway
LC20_RS16635	COG3043	anaerobic respiration
LC20_RS16640	COG0243	molybdopterin cofactor binding
LC20_RS16645	COG3062	negative regulation of establishment of protein localization
LC20_RS16655	COG2197	response regulator
LC20_RS16665	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LC20_RS16675	COG1393	Belongs to the ArsC family
LC20_RS16680	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LC20_RS16685	COG1876	peptidase activity
LC20_RS16695	COG0400	carboxylic ester hydrolase activity
LC20_RS16710	COG1444	tRNA N-acetyltransferase activity
LC20_RS16715	COG2707	UPF0756 membrane protein
LC20_RS16720	COG2321	neutral zinc metallopeptidase
LC20_RS16725	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
LC20_RS16730	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
LC20_RS16735	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LC20_RS16740	COG2716	regulation of RNA biosynthetic process
LC20_RS16745	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
LC20_RS16750	COG0628	permease
LC20_RS16755	COG4783	chaperone-mediated protein folding
LC20_RS16760	COG1393	Belongs to the ArsC family
LC20_RS16765	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LC20_RS16770	COG2233	PERMEase
LC20_RS16775	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
LC20_RS16780	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
LC20_RS16785	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
LC20_RS16790	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LC20_RS16800	COG0581	inorganic phosphate transmembrane transporter activity
LC20_RS16805	COG0573	inorganic phosphate transmembrane transporter activity
LC20_RS16810	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
LC20_RS16815	COG0248	Ppx GppA phosphatase
LC20_RS16830	COG2239	Acts as a magnesium transporter
LC20_RS16835	COG3447	MASE1 domain protein
LC20_RS16835	COG5001	Diguanylate cyclase
LC20_RS16835	COG5002	protein histidine kinase activity
LC20_RS16840	COG0443	Heat shock 70 kDa protein
LC20_RS16850	COG3121	Chaperone
LC20_RS16880	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LC20_RS16890	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LC20_RS16895	COG0477	Major facilitator Superfamily
LC20_RS16900	COG2205	protein histidine kinase activity
LC20_RS16905	COG0745	RESPONSE REGULATOR receiver
LC20_RS16910	COG3422	double-strand break repair
LC20_RS16915	COG0826	peptidase U32
LC20_RS16925	COG3730	PTS system glucitol sorbitol-specific
LC20_RS16940	COG1028	Short-chain dehydrogenase reductase Sdr
LC20_RS16945	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
LC20_RS16950	COG1349	DNA-binding transcription factor activity
LC20_RS16970	COG0351	phosphomethylpyrimidine kinase
LC20_RS16985	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LC20_RS16985	COG0519	Catalyzes the synthesis of GMP from XMP
LC20_RS16990	COG0517	IMP dehydrogenase activity
LC20_RS16990	COG0516	GMP reductase activity
LC20_RS16995	COG1570	exodeoxyribonuclease VII activity
LC20_RS17000	COG1645	bacterial-type flagellum-dependent swarming motility
LC20_RS17010	COG1160	GTP binding
LC20_RS17015	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LC20_RS17020	COG2976	Protein conserved in bacteria
LC20_RS17025	COG0124	histidyl-tRNA synthetase
LC20_RS17030	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
LC20_RS17045	COG0820	rRNA (adenine-C2-)-methyltransferase activity
LC20_RS17060	COG4953	penicillin-binding protein 1C
LC20_RS17065	COG2373	Large extracellular alpha-helical protein
LC20_RS17090	COG2975	iron-sulfur cluster assembly
LC20_RS17095	COG0633	Ferredoxin
LC20_RS17100	COG0443	Heat shock 70 kDa protein
LC20_RS17105	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
LC20_RS17120	COG0822	iron-sulfur transferase activity
LC20_RS17130	COG1959	2 iron, 2 sulfur cluster binding
LC20_RS17135	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
LC20_RS17145	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
LC20_RS17150	COG3683	transport system, periplasmic component
LC20_RS17155	COG3711	transcriptional antiterminator
LC20_RS17160	COG2814	Major facilitator Superfamily
LC20_RS17165	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LC20_RS17170	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LC20_RS17170	COG1017	nitric oxide dioxygenase activity
LC20_RS17175	COG2188	Transcriptional regulator
LC20_RS17185	COG3457	Alanine racemase
LC20_RS17190	COG1735	metal-dependent hydrolase with the TIM-barrel fold
LC20_RS17205	COG0347	Belongs to the P(II) protein family
LC20_RS17210	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LC20_RS17210	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
LC20_RS17215	COG2204	response regulator
LC20_RS17220	COG3170	Tfp pilus assembly protein FimV
LC20_RS17225	COG2205	protein histidine kinase activity
LC20_RS17245	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
LC20_RS17260	COG0560	Phosphoserine phosphatase
LC20_RS17270	COG1737	Transcriptional regulator
LC20_RS17275	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
LC20_RS17280	COG2610	gluconate transmembrane transporter activity
LC20_RS17285	COG0736	holo-[acyl-carrier-protein] synthase activity
LC20_RS17290	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
LC20_RS17295	COG1381	Involved in DNA repair and RecF pathway recombination
LC20_RS17300	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
LC20_RS17315	COG0481	GTPase activity
LC20_RS17325	COG3086	response to oxidative stress
LC20_RS17335	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
LC20_RS17345	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
LC20_RS17350	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
LC20_RS17355	COG0513	Belongs to the DEAD box helicase family
LC20_RS17370	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
LC20_RS17375	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
LC20_RS17380	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
LC20_RS17385	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
LC20_RS17390	COG0497	DNA recombination
LC20_RS17395	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LC20_RS17405	COG2867	negative regulation of translational initiation
LC20_RS17460	COG5301	cellulose 1,4-beta-cellobiosidase activity
LC20_RS17555	COG4695	Portal protein
LC20_RS17610	COG4974	Belongs to the 'phage' integrase family
LC20_RS17700	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
LC20_RS17705	COG4575	ribosome binding
LC20_RS17710	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
LC20_RS17715	COG1780	Probably involved in ribonucleotide reductase function
LC20_RS17725	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LC20_RS17735	COG4176	ABC-type proline glycine betaine transport system permease component
LC20_RS17740	COG2113	Glycine betaine
LC20_RS17760	COG2226	methyltransferase
LC20_RS17765	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LC20_RS17770	COG1388	LysM domain
LC20_RS17770	COG0741	lytic transglycosylase activity
LC20_RS17775	COG3021	interspecies interaction between organisms
LC20_RS17780	COG2814	Major facilitator Superfamily
LC20_RS17785	COG0583	DNA-binding transcription factor activity
LC20_RS17790	COG0656	L-ascorbic acid biosynthetic process
LC20_RS17830	COG0542	response to heat
LC20_RS17840	COG0564	pseudouridine synthase activity
LC20_RS17850	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LC20_RS17855	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
LC20_RS17860	COG1605	Chorismate mutase
LC20_RS17860	COG0077	Prephenate dehydratase
LC20_RS17865	COG0287	Prephenate dehydrogenase
LC20_RS17865	COG1605	Chorismate mutase
LC20_RS17870	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LC20_RS17875	COG3279	Response regulator of the LytR AlgR family
LC20_RS17880	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
LC20_RS17885	COG3137	Salt-induced outer membrane protein
LC20_RS17890	COG0335	large ribosomal subunit rRNA binding
LC20_RS17895	COG0336	Belongs to the RNA methyltransferase TrmD family
LC20_RS17900	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
LC20_RS17910	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
LC20_RS17915	COG4137	Cytochrome C assembly protein
LC20_RS17920	COG4536	flavin adenine dinucleotide binding
LC20_RS17925	COG1854	S-ribosylhomocysteine lyase activity
LC20_RS17930	COG2918	glutathione biosynthetic process
LC20_RS17935	COG1238	metal cluster binding
LC20_RS17940	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LC20_RS17970	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
LC20_RS17975	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LC20_RS17980	COG2137	regulation of response to DNA damage stimulus
LC20_RS17985	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
LC20_RS18010	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LC20_RS18015	COG3958	Transketolase
LC20_RS18020	COG3959	Transketolase, thiamine diphosphate binding domain
LC20_RS18025	COG1172	Belongs to the binding-protein-dependent transport system permease family
LC20_RS18030	COG1129	ABC transporter
LC20_RS18040	COG1879	ABC-type sugar transport system periplasmic component
LC20_RS18045	COG3381	protein complex oligomerization
LC20_RS18050	COG3302	dmso reductase anchor subunit
LC20_RS18055	COG0437	4 iron, 4 sulfur cluster binding
LC20_RS18060	COG0243	molybdopterin cofactor binding
LC20_RS18065	COG0235	Class ii aldolase
LC20_RS18070	COG1349	DNA-binding transcription factor activity
LC20_RS18080	COG1129	ABC transporter
LC20_RS18085	COG1172	Belongs to the binding-protein-dependent transport system permease family
LC20_RS18095	COG3623	hexulose-6-phosphate isomerase
LC20_RS18100	COG1070	Carbohydrate kinase
LC20_RS18105	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
LC20_RS18105	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
LC20_RS18125	COG1137	ATPase activity
LC20_RS18130	COG0410	ABC transporter
LC20_RS18190	COG0640	Transcriptional regulator
LC20_RS18195	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LC20_RS18200	COG3158	transport of potassium into the cell
LC20_RS18220	COG1126	abc transporter atp-binding protein
LC20_RS18230	COG0765	amino acid transport
LC20_RS18235	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LC20_RS18260	COG3048	D-serine ammonia-lyase activity
LC20_RS18265	COG2610	gluconate transmembrane transporter activity
LC20_RS18270	COG0583	DNA-binding transcription factor activity
LC20_RS18275	COG4608	Belongs to the ABC transporter superfamily
LC20_RS18280	COG0444	Belongs to the ABC transporter superfamily
LC20_RS18285	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LC20_RS18290	COG0601	transmembrane transport
LC20_RS18295	COG0747	negative chemotaxis
LC20_RS18300	COG4948	Mandelate Racemase Muconate Lactonizing
LC20_RS18305	COG1858	cytochrome C peroxidase
LC20_RS18310	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LC20_RS18320	COG1028	Short-chain dehydrogenase reductase Sdr
LC20_RS18340	COG1538	Outer membrane efflux protein
LC20_RS18345	COG0577	efflux transmembrane transporter activity
LC20_RS18345	COG1136	(ABC) transporter
LC20_RS18350	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LC20_RS18365	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LC20_RS18380	COG3539	Fimbrial protein
LC20_RS18385	COG3539	Fimbrial protein
LC20_RS18395	COG3121	Chaperone
LC20_RS18400	COG3188	usher protein
LC20_RS18425	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
LC20_RS18430	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LC20_RS18435	COG4942	peptidase
LC20_RS18435	COG1388	LysM domain
LC20_RS18440	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
LC20_RS18445	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
LC20_RS18450	COG0585	pseudouridine synthase activity
LC20_RS18455	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
LC20_RS18465	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
LC20_RS18475	COG0765	amino acid transport
LC20_RS18490	COG0529	Catalyzes the synthesis of activated sulfate
LC20_RS18495	COG2895	sulfate adenylyltransferase (ATP) activity
LC20_RS18500	COG0175	sulfate reduction
LC20_RS18505	COG1648	precorrin-2 dehydrogenase activity
LC20_RS18505	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LC20_RS18510	COG2234	aminopeptidase activity
LC20_RS18515	COG0175	sulfate reduction
LC20_RS18520	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LC20_RS18525	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
LC20_RS18530	COG0720	synthase
LC20_RS18535	COG0602	queuosine metabolic process
LC20_RS18545	COG0148	phosphopyruvate hydratase activity
LC20_RS18550	COG0504	CTP synthase activity
LC20_RS18555	COG3956	TIGRFAM MazG family protein
LC20_RS18560	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LC20_RS18565	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LC20_RS18570	COG2205	protein histidine kinase activity
LC20_RS18570	COG4999	Histidine kinase
LC20_RS18570	COG3850	Histidine kinase
LC20_RS18570	COG3437	response regulator, receiver
LC20_RS18575	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LC20_RS18580	COG0232	Belongs to the dGTPase family. Type 2 subfamily
LC20_RS18585	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
LC20_RS18595	COG2860	membrane
LC20_RS18605	COG0316	Belongs to the HesB IscA family
LC20_RS18615	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
LC20_RS18620	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LC20_RS18625	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LC20_RS18630	COG1120	ATPase activity
LC20_RS18635	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LC20_RS18650	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
LC20_RS18655	COG1489	DNA binding
LC20_RS18670	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LC20_RS18675	COG0617	tRNA 3'-terminal CCA addition
LC20_RS18680	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
LC20_RS18685	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
LC20_RS18690	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
LC20_RS18695	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
LC20_RS18700	COG0726	polysaccharide deacetylase
LC20_RS18705	COG0842	Transport permease protein
LC20_RS18710	COG1131	(ABC) transporter
LC20_RS18715	COG0288	reversible hydration of carbon dioxide
LC20_RS18720	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
LC20_RS18725	COG2132	Multicopper oxidase
LC20_RS18735	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
LC20_RS18745	COG0697	spore germination
LC20_RS18750	COG3112	Uncharacterised protein family (UPF0231)
LC20_RS18755	COG1049	propionate catabolic process, 2-methylcitrate cycle
LC20_RS18780	COG3328	transposase activity
LC20_RS18785	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LC20_RS18790	COG0508	dehydrogenase complex catalyzes the overall conversion of
LC20_RS18795	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
LC20_RS18805	COG2186	Transcriptional regulator
LC20_RS18810	COG1113	amino acid transport
LC20_RS18830	COG3725	Membrane protein required for beta-lactamase induction
LC20_RS18835	COG3023	N-Acetylmuramoyl-L-alanine amidase
LC20_RS18855	COG3328	transposase activity
LC20_RS18860	COG0516	GMP reductase activity
LC20_RS18880	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
LC20_RS18885	COG0494	nUDIX hydrolase
LC20_RS18890	COG0653	protein targeting
LC20_RS18910	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
LC20_RS18915	COG0849	cell division
LC20_RS18920	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
LC20_RS18930	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LC20_RS18935	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LC20_RS18940	COG0772	Belongs to the SEDS family
LC20_RS18950	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LC20_RS18955	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LC20_RS18960	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LC20_RS18965	COG0768	penicillin binding
LC20_RS18970	COG3116	cell division
LC20_RS18975	COG0275	rRNA processing
LC20_RS19000	COG0028	Belongs to the TPP enzyme family
LC20_RS19005	COG1022	Amp-dependent synthetase and ligase
LC20_RS19015	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LC20_RS19020	COG0473	3-isopropylmalate dehydrogenase activity
LC20_RS19025	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
LC20_RS19040	COG3033	Beta-eliminating lyase
LC20_RS19045	COG0814	amino acid
LC20_RS19050	COG2814	Major facilitator Superfamily
LC20_RS19055	COG1882	Formate acetyltransferase
LC20_RS19060	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
LC20_RS19065	COG4533	DNA binding
LC20_RS19070	COG4143	(ABC) transporter
LC20_RS19075	COG1178	ABC-type Fe3 transport system permease component
LC20_RS19085	COG0586	Pfam SNARE associated Golgi protein
LC20_RS19090	COG0417	DNA replication proofreading
LC20_RS19095	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LC20_RS19100	COG0564	pseudouridine synthase activity
LC20_RS19110	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
LC20_RS19115	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
LC20_RS19125	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
LC20_RS19135	COG2967	ApaG domain
LC20_RS19140	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
LC20_RS19145	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
LC20_RS19150	COG3610	response to peptide
LC20_RS19155	COG2966	Psort location CytoplasmicMembrane, score
LC20_RS19160	COG1280	lysine exporter protein (LysE YggA)
LC20_RS19165	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LC20_RS19175	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
LC20_RS19180	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
LC20_RS19185	COG1047	Peptidyl-prolyl cis-trans
LC20_RS19190	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
LC20_RS19195	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
LC20_RS19200	COG0196	riboflavin kinase activity
LC20_RS19215	COG0583	DNA-binding transcription factor activity
LC20_RS19220	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
LC20_RS19225	COG0484	heat shock protein binding
LC20_RS19235	COG1584	GPR1 FUN34 yaaH family protein
LC20_RS19250	COG0521	Mo-molybdopterin cofactor biosynthetic process
LC20_RS19255	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LC20_RS19265	COG3022	response to hydroperoxide
LC20_RS19275	COG0083	homoserine kinase activity
LC20_RS19290	COG0745	RESPONSE REGULATOR receiver
LC20_RS19295	COG3045	CreA protein
LC20_RS19300	COG3708	Transcriptional regulator
LC20_RS19300	COG2207	Transcriptional regulator
LC20_RS19305	COG0406	alpha-ribazole phosphatase activity
LC20_RS19310	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
LC20_RS19315	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
LC20_RS19320	COG0741	lytic transglycosylase activity
LC20_RS19325	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
LC20_RS19335	COG2199	diguanylate cyclase activity
LC20_RS19340	COG2885	chlorophyll binding
LC20_RS19345	COG0488	(ABC) transporter
LC20_RS19355	COG0604	alcohol dehydrogenase
LC20_RS19380	COG0560	Phosphoserine phosphatase
LC20_RS19385	COG3726	membrane protein affecting hemolysin expression
LC20_RS19395	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
LC20_RS19400	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
LC20_RS19415	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LC20_RS19420	COG0084	hydrolase, TatD family'
LC20_RS19425	COG4667	esterase of the alpha-beta hydrolase superfamily
LC20_RS19435	COG2823	Periplasmic or secreted lipoprotein
LC20_RS19440	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
LC20_RS19450	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
LC20_RS19455	COG2813	Specifically methylates the guanine in position
LC20_RS19460	COG0667	Aldo Keto reductase
LC20_RS19545	COG2192	nodulation
LC20_RS19555	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LC20_RS19555	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
LC20_RS19555	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LC20_RS19560	COG1461	Dihydroxyacetone kinase
LC20_RS19565	COG2376	Dihydroxyacetone kinase
LC20_RS19575	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LC20_RS19580	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LC20_RS19590	COG2235	arginine
LC20_RS19615	COG0859	PFAM glycosyl transferase family 9
LC20_RS19620	COG1070	Carbohydrate kinase
LC20_RS19625	COG2390	Transcriptional regulator
LC20_RS19635	COG1129	ABC transporter
LC20_RS19640	COG1172	Belongs to the binding-protein-dependent transport system permease family
LC20_RS19645	COG1172	Belongs to the binding-protein-dependent transport system permease family
LC20_RS19650	COG1879	ABC-type sugar transport system periplasmic component
LC20_RS19655	COG1830	Aldolase
LC20_RS19660	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
LC20_RS19665	COG3272	Protein of unknown function (DUF1722)
LC20_RS19690	COG0454	-acetyltransferase
LC20_RS19710	COG0795	lipopolysaccharide-transporting ATPase activity
LC20_RS19715	COG0795	lipopolysaccharide-transporting ATPase activity
LC20_RS19720	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LC20_RS19725	COG2927	DNA polymerase III (CHI subunit)
LC20_RS19745	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
LC20_RS19755	COG2731	YhcH YjgK YiaL family protein
LC20_RS19765	COG0601	transmembrane transport
LC20_RS19770	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LC20_RS19775	COG0444	Belongs to the ABC transporter superfamily
LC20_RS19780	COG4608	Belongs to the ABC transporter superfamily
LC20_RS19785	COG2249	NAD(P)H dehydrogenase (quinone) activity
LC20_RS19790	COG0583	DNA-binding transcription factor activity
LC20_RS19800	COG0602	queuosine metabolic process
LC20_RS19815	COG2188	Transcriptional regulator
LC20_RS19820	COG3624	Phosphonate C-P lyase system protein PhnG
LC20_RS19825	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
LC20_RS19830	COG3626	phosphonate metabolism
LC20_RS19835	COG3627	carbon phosphorus lyase activity
LC20_RS19840	COG4107	phosphonate C-P lyase system protein PhnK
LC20_RS19845	COG4778	phosphonate C-P lyase system protein PhnL
LC20_RS19850	COG3454	Phosphonate metabolism
LC20_RS19855	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
LC20_RS19860	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
LC20_RS19865	COG0702	epimerase
LC20_RS19870	COG3787	Belongs to the UPF0306 family
LC20_RS19880	COG3842	ATPase activity
LC20_RS19885	COG0395	ABC-type sugar transport system, permease component
LC20_RS19890	COG1175	transmembrane transport
LC20_RS19895	COG1653	transport
LC20_RS19910	COG1982	Orn Lys Arg decarboxylase major
LC20_RS19915	COG0531	amino acid
LC20_RS19925	COG3153	acetyltransferase
LC20_RS19930	COG3154	lipid carrier protein
LC20_RS19935	COG0826	peptidase U32
LC20_RS19940	COG0826	peptidase U32
LC20_RS19960	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LC20_RS19965	COG0513	Belongs to the DEAD box helicase family
LC20_RS19980	COG1185	polyribonucleotide nucleotidyltransferase activity
LC20_RS19990	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
LC20_RS19995	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
LC20_RS20005	COG0195	Participates in both transcription termination and antitermination
LC20_RS20025	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LC20_RS20035	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
LC20_RS20045	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
LC20_RS20050	COG1534	Rna-binding protein
LC20_RS20060	COG2027	D-alanyl-D-alanine carboxypeptidase
LC20_RS20065	COG0745	RESPONSE REGULATOR receiver
LC20_RS20070	COG0642	Histidine kinase
LC20_RS20075	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
LC20_RS20080	COG0697	spore germination
LC20_RS20095	COG0142	geranyltranstransferase activity
LC20_RS20105	COG3423	Transcriptional regulator
LC20_RS20110	COG0039	L-malate dehydrogenase activity
LC20_RS20115	COG1438	arginine binding
LC20_RS20125	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LC20_RS20130	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
LC20_RS20135	COG0840	transmembrane signaling receptor activity
LC20_RS20140	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
LC20_RS20145	COG2105	PFAM AIG2 family protein
LC20_RS20150	COG2911	Protein conserved in bacteria
LC20_RS20155	COG0729	surface antigen
LC20_RS20160	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LC20_RS20165	COG1253	flavin adenine dinucleotide binding
LC20_RS20175	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
LC20_RS20180	COG1218	3'(2'),5'-bisphosphate nucleotidase
LC20_RS20185	COG0737	Belongs to the 5'-nucleotidase family
LC20_RS20195	COG0545	Peptidyl-prolyl cis-trans isomerase
LC20_RS20200	COG3061	Opacity-associated protein A
LC20_RS20210	COG0359	binds to the 23S rRNA
LC20_RS20215	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
LC20_RS20220	COG2965	DNA replication, synthesis of RNA primer
LC20_RS20225	COG0360	Binds together with S18 to 16S ribosomal RNA
LC20_RS20240	COG1073	alpha beta
LC20_RS20245	COG3650	response to hydrogen peroxide
LC20_RS20250	COG1960	acyl-CoA dehydrogenase activity
LC20_RS20255	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LC20_RS20260	COG0557	exoribonuclease II activity
LC20_RS20265	COG1959	2 iron, 2 sulfur cluster binding
LC20_RS20270	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
LC20_RS20275	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
LC20_RS20285	COG0330	HflC and HflK could
LC20_RS20290	COG0330	HflC and HflK could
LC20_RS20295	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LC20_RS20300	COG1923	regulation of RNA biosynthetic process
LC20_RS20305	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
LC20_RS20310	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
LC20_RS20315	COG0860	N-Acetylmuramoyl-L-alanine amidase
LC20_RS20320	COG0802	atpase or kinase
LC20_RS20325	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
LC20_RS20325	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
LC20_RS20330	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
LC20_RS20355	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
LC20_RS20360	COG1162	GTPase activity
LC20_RS20365	COG0688	phosphatidylethanolamine metabolic process
LC20_RS20370	COG1511	domain protein
LC20_RS20370	COG3264	Mechanosensitive ion channel
LC20_RS20375	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
LC20_RS20380	COG1053	succinate dehydrogenase
LC20_RS20385	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
LC20_RS20390	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
LC20_RS20395	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
LC20_RS20410	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LC20_RS20430	COG0459	protein refolding
LC20_RS20435	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
LC20_RS20450	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
LC20_RS20460	COG4232	protein-disulfide reductase activity
LC20_RS20465	COG3383	formate dehydrogenase (NAD+) activity
LC20_RS20470	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
LC20_RS20480	COG3835	regulator
LC20_RS20490	COG2084	Dehydrogenase
LC20_RS20495	COG3836	Belongs to the HpcH HpaI aldolase family
LC20_RS20505	COG1309	transcriptional regulator
LC20_RS20550	COG3720	iron ion transport
LC20_RS20555	COG4558	Periplasmic binding protein
LC20_RS20560	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LC20_RS20565	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
LC20_RS20570	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LC20_RS20600	COG1960	acyl-CoA dehydrogenase activity
LC20_RS20620	COG4774	siderophore transport
LC20_RS20625	COG3264	Mechanosensitive ion channel
LC20_RS20625	COG1196	nuclear chromosome segregation
LC20_RS20630	COG0425	Belongs to the sulfur carrier protein TusA family
LC20_RS20635	COG2391	methyltransferase activity
LC20_RS20800	COG1301	dicarboxylic acid transport
LC20_RS20805	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LC20_RS20810	COG3162	membrane
LC20_RS20815	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LC20_RS20860	COG0138	bifunctional purine biosynthesis protein purh
LC20_RS20865	COG0151	Belongs to the GarS family
LC20_RS20885	COG1515	deoxyribonuclease V activity
LC20_RS20890	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
LC20_RS20895	COG2816	NAD+ diphosphatase activity
LC20_RS20900	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
LC20_RS20915	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
LC20_RS20920	COG2104	thiamine diphosphate biosynthetic process
LC20_RS20925	COG2022	thiamine diphosphate biosynthetic process
LC20_RS20935	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
LC20_RS20940	COG0085	RNA polymerase activity
LC20_RS20945	COG0222	ribosome binding
LC20_RS20960	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
LC20_RS20965	COG0250	Participates in transcription elongation, termination and antitermination
LC20_RS21005	COG1072	(Pantothenic acid kinase))
LC20_RS21050	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LC20_RS21055	COG1739	Uncharacterized protein family UPF0029
LC20_RS21065	COG1250	3-hydroxyacyl-CoA dehydrogenase
LC20_RS21065	COG1024	Enoyl-CoA hydratase
LC20_RS21070	COG0183	Belongs to the thiolase family
LC20_RS21080	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
LC20_RS21100	COG0805	protein transport
LC20_RS21105	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LC20_RS21110	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LC20_RS21115	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
LC20_RS21125	COG2226	methyltransferase
LC20_RS21130	COG1322	Protein conserved in bacteria
LC20_RS21135	COG0586	Pfam SNARE associated Golgi protein
LC20_RS21140	COG1966	Carbon starvation protein
LC20_RS21155	COG0412	Dienelactone hydrolase
LC20_RS21160	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
LC20_RS21165	COG0583	DNA-binding transcription factor activity
LC20_RS21170	COG0697	spore germination
LC20_RS21175	COG0679	Auxin Efflux Carrier
LC20_RS21180	COG0584	glycerophosphoryl diester phosphodiesterase
LC20_RS21185	COG3842	ATPase activity
LC20_RS21190	COG0395	ABC-type sugar transport system, permease component
LC20_RS21195	COG1175	transmembrane transport
LC20_RS21200	COG1653	transport
LC20_RS21250	COG0410	ABC transporter
LC20_RS21260	COG4177	L-phenylalanine transmembrane transporter activity
LC20_RS21270	COG0683	leucine binding
LC20_RS21275	COG0456	acetyltransferase
LC20_RS21285	COG2177	Part of the ABC transporter FtsEX involved in
LC20_RS21290	COG2884	Cell division ATP-binding protein ftsE
LC20_RS21295	COG0552	protein localization to endoplasmic reticulum
LC20_RS21300	COG0742	ribosomal rna small subunit methyltransferase
LC20_RS21305	COG3776	membrane
LC20_RS21320	COG3714	YhhN family
LC20_RS21330	COG0425	Belongs to the sulfur carrier protein TusA family
LC20_RS21335	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
LC20_RS21345	COG0247	lactate metabolic process
LC20_RS21355	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
LC20_RS21360	COG2271	Major facilitator Superfamily
LC20_RS21365	COG0584	glycerophosphoryl diester phosphodiesterase
LC20_RS21370	COG0561	phosphatase activity
LC20_RS21375	COG2267	carboxylic ester hydrolase activity
LC20_RS21380	COG1280	lysine exporter protein (LysE YggA)
LC20_RS21385	COG1280	lysine exporter protein (LysE YggA)
LC20_RS21390	COG0514	ATP-dependent DNA helicase (RecQ)
LC20_RS21395	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
LC20_RS21400	COG2050	protein possibly involved in aromatic compounds catabolism
LC20_RS21420	COG5564	TIM-barrel signal transduction protein
LC20_RS21425	COG5441	Belongs to the UPF0261 family
LC20_RS21440	COG0210	DNA helicase
LC20_RS21445	COG1011	Hydrolase
LC20_RS21450	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
LC20_RS21455	COG3159	Protein conserved in bacteria
LC20_RS21460	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
LC20_RS21465	COG5567	small periplasmic lipoprotein
LC20_RS21470	COG1965	Belongs to the frataxin family
LC20_RS21475	COG3072	Adenylate cyclase
LC20_RS21485	COG0181	hydroxymethylbilane synthase activity
LC20_RS21490	COG1587	Uroporphyrinogen-III synthase
LC20_RS21495	COG2959	enzyme of heme biosynthesis
LC20_RS21500	COG3071	HemY protein
LC20_RS21525	COG1113	amino acid transport
LC20_RS21540	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LC20_RS21545	COG2244	polysaccharide biosynthetic process
LC20_RS21550	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LC20_RS21555	COG0456	acetyltransferase
LC20_RS21560	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
LC20_RS21565	COG1088	dTDP-glucose 4,6-dehydratase activity
LC20_RS21570	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
LC20_RS21575	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
LC20_RS21580	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
LC20_RS21585	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LC20_RS21590	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
LC20_RS21595	COG3118	belongs to the thioredoxin family
LC20_RS21605	COG0248	Ppx GppA phosphatase
LC20_RS21620	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LC20_RS21635	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
LC20_RS21640	COG0583	DNA-binding transcription factor activity
LC20_RS21645	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LC20_RS21650	COG0129	dihydroxy-acid dehydratase activity
LC20_RS21655	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LC20_RS21660	COG3978	acetolactate synthase activity
LC20_RS21730	COG3085	chromosome segregation
LC20_RS21735	COG0583	DNA-binding transcription factor activity
LC20_RS21740	COG1172	Belongs to the binding-protein-dependent transport system permease family
LC20_RS21745	COG1172	Belongs to the binding-protein-dependent transport system permease family
LC20_RS21750	COG1129	ABC transporter
LC20_RS21755	COG1879	ABC-type sugar transport system periplasmic component
LC20_RS21800	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
LC20_RS21810	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LC20_RS21820	COG1309	transcriptional regulator
LC20_RS21825	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LC20_RS21835	COG0678	peroxiredoxin activity
LC20_RS21835	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
LC20_RS21840	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LC20_RS21870	COG1629	transport
LC20_RS21875	COG0165	Argininosuccinate lyase
LC20_RS21895	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
LC20_RS21905	COG0527	aspartate kinase activity
LC20_RS21905	COG0460	homoserine dehydrogenase
LC20_RS21910	COG0626	cystathionine gamma-synthase activity
LC20_RS21915	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
LC20_RS21925	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
LC20_RS21935	COG1609	Transcriptional regulator
LC20_RS21940	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
LC20_RS21950	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
LC20_RS21955	COG1575	Belongs to the MenA family. Type 1 subfamily
LC20_RS21960	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
LC20_RS21965	COG3074	FtsZ-dependent cytokinesis
LC20_RS21980	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LC20_RS21990	COG1494	fructose-1,6-bisphosphatase
LC20_RS21995	COG2814	Major facilitator Superfamily
LC20_RS22005	COG3152	Membrane
LC20_RS22015	COG0149	triose-phosphate isomerase activity
LC20_RS22025	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
LC20_RS22040	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
LC20_RS22045	COG3678	ATP-independent chaperone mediated protein folding
LC20_RS22050	COG0745	RESPONSE REGULATOR receiver
LC20_RS22055	COG2205	protein histidine kinase activity
LC20_RS22060	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LC20_RS22060	COG2169	Transcriptional regulator
LC20_RS22065	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
LC20_RS22075	COG1045	serine acetyltransferase
LC20_RS22080	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
LC20_RS22085	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
LC20_RS22090	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
LC20_RS22095	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LC20_RS22100	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
LC20_RS22105	COG4942	peptidase
LC20_RS22110	COG2861	carbohydrate metabolic process
LC20_RS22120	COG0156	8-amino-7-oxononanoate synthase activity
LC20_RS22125	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LC20_RS22130	COG0859	PFAM glycosyl transferase family 9
LC20_RS22135	COG0859	PFAM glycosyl transferase family 9
LC20_RS22140	COG1519	Transferase
LC20_RS22150	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
LC20_RS22155	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LC20_RS22160	COG0267	Belongs to the bacterial ribosomal protein bL33 family
LC20_RS22165	COG0227	Belongs to the bacterial ribosomal protein bL28 family
LC20_RS22180	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
LC20_RS22185	COG0756	dUTP diphosphatase activity
LC20_RS22190	COG1309	transcriptional regulator
LC20_RS22195	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
LC20_RS22205	COG1561	YicC-like family, N-terminal region
LC20_RS22285	COG3328	transposase activity
LC20_RS22300	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LC20_RS22310	COG2860	membrane
LC20_RS22315	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LC20_RS22325	COG1758	RNA polymerase activity
LC20_RS22330	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LC20_RS22335	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LC20_RS22340	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LC20_RS22345	COG0786	glutamate:sodium symporter activity
LC20_RS22350	COG2233	PERMEase
LC20_RS22355	COG2982	Protein involved in outer membrane biogenesis
LC20_RS22370	COG3423	Transcriptional regulator
LC20_RS22375	COG0456	acetyltransferase
LC20_RS22380	COG1490	D-aminoacyl-tRNA deacylase activity
LC20_RS22385	COG1295	ribonuclease BN
LC20_RS22390	COG1011	Hydrolase
LC20_RS22405	COG3852	Histidine kinase
LC20_RS22415	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LC20_RS22425	COG3078	GTPase activator activity
LC20_RS22430	COG0218	Necessary for normal cell division and for the maintenance of normal septation
LC20_RS22435	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LC20_RS22435	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LC20_RS22440	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LC20_RS22445	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
LC20_RS22460	COG1763	Mo-molybdopterin cofactor biosynthetic process
LC20_RS22490	COG2186	Transcriptional regulator
LC20_RS22495	COG0477	Major facilitator Superfamily
LC20_RS22500	COG1609	Transcriptional regulator
LC20_RS22505	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LC20_RS22510	COG1879	ABC-type sugar transport system periplasmic component
LC20_RS22520	COG1129	ABC transporter
LC20_RS22525	COG1869	D-ribose catabolic process
LC20_RS22565	COG1522	sequence-specific DNA binding
LC20_RS22570	COG0716	FMN binding
LC20_RS22575	COG0445	tRNA wobble uridine modification
LC20_RS22580	COG0357	Ribosomal RNA small subunit methyltransferase G
LC20_RS22585	COG3312	ion transport
LC20_RS22590	COG0356	it plays a direct role in the translocation of protons across the membrane
LC20_RS22600	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
LC20_RS22605	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LC20_RS22610	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
LC20_RS22615	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
LC20_RS22620	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
LC20_RS22625	COG0355	proton-transporting ATP synthase activity, rotational mechanism
LC20_RS22630	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
LC20_RS22650	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
LC20_RS22655	COG0573	inorganic phosphate transmembrane transporter activity
LC20_RS22660	COG0581	inorganic phosphate transmembrane transporter activity
LC20_RS22670	COG0704	Plays a role in the regulation of phosphate uptake
LC20_RS22675	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LC20_RS22680	COG0765	amino acid transport
LC20_RS22685	COG0765	amino acid transport
LC20_RS22690	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LC20_RS22695	COG2252	PERMEase
LC20_RS22715	COG0431	NADPH-dependent FMN reductase
LC20_RS22720	COG0840	transmembrane signaling receptor activity
LC20_RS22725	COG2011	ABC-type metal ion transport system permease component
LC20_RS22740	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
LC20_RS22745	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
LC20_RS22750	COG0706	membrane insertase activity
LC20_RS22755	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
LC20_RS22760	COG0594	ribonuclease P activity
LC20_RS22765	COG0230	Belongs to the bacterial ribosomal protein bL34 family
LC20_RS22805	COG3328	transposase activity
LC20_RS22820	COG3093	addiction module antidote protein HigA
LC20_RS22825	COG3549	Plasmid maintenance system killer
LC20_RS22945	COG3328	transposase activity
LC20_RS23270	COG2337	Toxic component of a toxin-antitoxin (TA) module
LC20_RS23355	COG1192	Involved in chromosome partitioning
LC20_RS23395	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
LC20_RS23420	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs