locus-tag	class	description
BED33_RS00035	COG2192	nodulation
BED33_RS00050	COG1461	Dihydroxyacetone kinase
BED33_RS00055	COG2376	Dihydroxyacetone kinase
BED33_RS00065	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BED33_RS00070	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BED33_RS00075	COG2235	arginine
BED33_RS00090	COG0859	PFAM glycosyl transferase family 9
BED33_RS00095	COG1070	Carbohydrate kinase
BED33_RS00100	COG2390	Transcriptional regulator
BED33_RS00105	COG1129	ABC transporter
BED33_RS00110	COG1172	Belongs to the binding-protein-dependent transport system permease family
BED33_RS00115	COG1172	Belongs to the binding-protein-dependent transport system permease family
BED33_RS00120	COG1879	ABC-type sugar transport system periplasmic component
BED33_RS00125	COG1830	Aldolase
BED33_RS00130	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
BED33_RS00145	COG3328	transposase activity
BED33_RS00175	COG0795	lipopolysaccharide-transporting ATPase activity
BED33_RS00180	COG0795	lipopolysaccharide-transporting ATPase activity
BED33_RS00185	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BED33_RS00190	COG2927	DNA polymerase III (CHI subunit)
BED33_RS00205	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
BED33_RS00215	COG2731	YhcH YjgK YiaL family protein
BED33_RS00225	COG0601	transmembrane transport
BED33_RS00230	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BED33_RS00235	COG0444	Belongs to the ABC transporter superfamily
BED33_RS00240	COG4608	Belongs to the ABC transporter superfamily
BED33_RS00270	COG2188	Transcriptional regulator
BED33_RS00275	COG3624	Phosphonate C-P lyase system protein PhnG
BED33_RS00280	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
BED33_RS00285	COG3626	phosphonate metabolism
BED33_RS00290	COG3627	carbon phosphorus lyase activity
BED33_RS00295	COG4107	phosphonate C-P lyase system protein PhnK
BED33_RS00300	COG4778	phosphonate C-P lyase system protein PhnL
BED33_RS00305	COG3454	Phosphonate metabolism
BED33_RS00310	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
BED33_RS00315	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
BED33_RS00320	COG0702	epimerase
BED33_RS00335	COG3787	Belongs to the UPF0306 family
BED33_RS00345	COG3842	ATPase activity
BED33_RS00350	COG0395	ABC-type sugar transport system, permease component
BED33_RS00355	COG1175	transmembrane transport
BED33_RS00360	COG1653	transport
BED33_RS00375	COG1982	Orn Lys Arg decarboxylase major
BED33_RS00380	COG0531	amino acid
BED33_RS00390	COG3153	acetyltransferase
BED33_RS00395	COG3154	lipid carrier protein
BED33_RS00400	COG0826	peptidase U32
BED33_RS00405	COG0826	peptidase U32
BED33_RS00410	COG3681	Belongs to the UPF0597 family
BED33_RS00415	COG0814	amino acid
BED33_RS00425	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BED33_RS00435	COG0513	Belongs to the DEAD box helicase family
BED33_RS00445	COG1185	polyribonucleotide nucleotidyltransferase activity
BED33_RS00450	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BED33_RS00455	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BED33_RS00460	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BED33_RS00465	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BED33_RS00470	COG0195	Participates in both transcription termination and antitermination
BED33_RS00475	COG0779	Required for maturation of 30S ribosomal subunits
BED33_RS00490	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BED33_RS00495	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BED33_RS00500	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BED33_RS00510	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
BED33_RS00515	COG1534	Rna-binding protein
BED33_RS00525	COG2027	D-alanyl-D-alanine carboxypeptidase
BED33_RS00530	COG0745	RESPONSE REGULATOR receiver
BED33_RS00535	COG0642	Histidine kinase
BED33_RS00540	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BED33_RS00545	COG0697	spore germination
BED33_RS00550	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BED33_RS00555	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BED33_RS00560	COG0142	geranyltranstransferase activity
BED33_RS00570	COG3423	Transcriptional regulator
BED33_RS00575	COG0039	L-malate dehydrogenase activity
BED33_RS00580	COG1438	arginine binding
BED33_RS00590	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BED33_RS00595	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
BED33_RS00605	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
BED33_RS00610	COG2105	PFAM AIG2 family protein
BED33_RS00625	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BED33_RS00630	COG1253	flavin adenine dinucleotide binding
BED33_RS00640	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
BED33_RS00645	COG1218	3'(2'),5'-bisphosphate nucleotidase
BED33_RS00650	COG0737	Belongs to the 5'-nucleotidase family
BED33_RS00660	COG0545	Peptidyl-prolyl cis-trans isomerase
BED33_RS00665	COG3061	Opacity-associated protein A
BED33_RS00675	COG0359	binds to the 23S rRNA
BED33_RS00680	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BED33_RS00685	COG2965	DNA replication, synthesis of RNA primer
BED33_RS00690	COG0360	Binds together with S18 to 16S ribosomal RNA
BED33_RS00700	COG1073	alpha beta
BED33_RS00705	COG3650	response to hydrogen peroxide
BED33_RS00710	COG1960	acyl-CoA dehydrogenase activity
BED33_RS00720	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BED33_RS00725	COG0557	exoribonuclease II activity
BED33_RS00730	COG1959	2 iron, 2 sulfur cluster binding
BED33_RS00735	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
BED33_RS00740	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
BED33_RS00745	COG0330	HflC and HflK could
BED33_RS00750	COG0330	HflC and HflK could
BED33_RS00755	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BED33_RS00760	COG1923	regulation of RNA biosynthetic process
BED33_RS00765	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BED33_RS00770	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BED33_RS00775	COG0860	N-Acetylmuramoyl-L-alanine amidase
BED33_RS00780	COG0802	atpase or kinase
BED33_RS00785	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
BED33_RS00785	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BED33_RS00790	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BED33_RS00805	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
BED33_RS00810	COG1162	GTPase activity
BED33_RS00815	COG0688	phosphatidylethanolamine metabolic process
BED33_RS00820	COG3264	Mechanosensitive ion channel
BED33_RS00820	COG1511	domain protein
BED33_RS00825	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
BED33_RS00830	COG1053	succinate dehydrogenase
BED33_RS00835	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BED33_RS00840	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
BED33_RS00845	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
BED33_RS00865	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BED33_RS00885	COG0459	protein refolding
BED33_RS00890	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
BED33_RS00905	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
BED33_RS00915	COG4232	protein-disulfide reductase activity
BED33_RS00920	COG1929	Belongs to the glycerate kinase type-1 family
BED33_RS00925	COG1309	transcriptional regulator
BED33_RS00935	COG1882	Formate acetyltransferase
BED33_RS00940	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BED33_RS00945	COG0814	amino acid
BED33_RS00950	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BED33_RS00960	COG3721	Heme iron utilization protein
BED33_RS00980	COG3720	iron ion transport
BED33_RS00985	COG4558	Periplasmic binding protein
BED33_RS00990	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BED33_RS00995	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
BED33_RS01010	COG4774	siderophore transport
BED33_RS01020	COG4115	mRNA cleavage
BED33_RS01025	COG2161	toxin-antitoxin pair type II binding
BED33_RS01035	COG4178	(ABC) transporter
BED33_RS01040	COG4771	TonB-dependent receptor
BED33_RS01045	COG3712	iron ion homeostasis
BED33_RS01060	COG0425	Belongs to the sulfur carrier protein TusA family
BED33_RS01065	COG2391	methyltransferase activity
BED33_RS01225	COG2197	response regulator
BED33_RS01230	COG1301	dicarboxylic acid transport
BED33_RS01235	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BED33_RS01240	COG3162	membrane
BED33_RS01245	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BED33_RS01290	COG0138	bifunctional purine biosynthesis protein purh
BED33_RS01295	COG0151	Belongs to the GarS family
BED33_RS01315	COG1515	deoxyribonuclease V activity
BED33_RS01320	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
BED33_RS01325	COG2816	NAD+ diphosphatase activity
BED33_RS01330	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
BED33_RS01345	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BED33_RS01350	COG2104	thiamine diphosphate biosynthetic process
BED33_RS01355	COG2022	thiamine diphosphate biosynthetic process
BED33_RS01370	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BED33_RS01375	COG0085	RNA polymerase activity
BED33_RS01385	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BED33_RS01390	COG0081	regulation of translation
BED33_RS01395	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BED33_RS01400	COG0250	Participates in transcription elongation, termination and antitermination
BED33_RS01410	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BED33_RS01445	COG1072	(Pantothenic acid kinase))
BED33_RS01450	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
BED33_RS01450	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
BED33_RS01495	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BED33_RS01500	COG1739	Uncharacterized protein family UPF0029
BED33_RS01505	COG0006	proline dipeptidase activity
BED33_RS01510	COG1250	3-hydroxyacyl-CoA dehydrogenase
BED33_RS01510	COG1024	Enoyl-CoA hydratase
BED33_RS01515	COG0183	Belongs to the thiolase family
BED33_RS01525	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
BED33_RS01545	COG0805	protein transport
BED33_RS01550	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BED33_RS01555	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BED33_RS01560	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BED33_RS01570	COG2226	methyltransferase
BED33_RS01580	COG0586	Pfam SNARE associated Golgi protein
BED33_RS01585	COG1966	Carbon starvation protein
BED33_RS01600	COG0412	Dienelactone hydrolase
BED33_RS01605	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BED33_RS01610	COG0583	DNA-binding transcription factor activity
BED33_RS01615	COG0697	spore germination
BED33_RS01620	COG0679	Auxin Efflux Carrier
BED33_RS01625	COG0584	glycerophosphoryl diester phosphodiesterase
BED33_RS01630	COG3842	ATPase activity
BED33_RS01635	COG0395	ABC-type sugar transport system, permease component
BED33_RS01640	COG1175	transmembrane transport
BED33_RS01645	COG1653	transport
BED33_RS01680	COG0410	ABC transporter
BED33_RS01690	COG4177	L-phenylalanine transmembrane transporter activity
BED33_RS01700	COG0683	leucine binding
BED33_RS01725	COG2177	Part of the ABC transporter FtsEX involved in
BED33_RS01730	COG2884	Cell division ATP-binding protein ftsE
BED33_RS01735	COG0552	protein localization to endoplasmic reticulum
BED33_RS01740	COG0742	ribosomal rna small subunit methyltransferase
BED33_RS01745	COG3776	membrane
BED33_RS01760	COG3714	YhhN family
BED33_RS01765	COG2217	Heavy metal translocating P-type atpase
BED33_RS01770	COG0425	Belongs to the sulfur carrier protein TusA family
BED33_RS01775	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
BED33_RS01785	COG0247	lactate metabolic process
BED33_RS01790	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
BED33_RS01795	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
BED33_RS01800	COG2271	Major facilitator Superfamily
BED33_RS01805	COG0584	glycerophosphoryl diester phosphodiesterase
BED33_RS01810	COG0561	phosphatase activity
BED33_RS01815	COG2267	carboxylic ester hydrolase activity
BED33_RS01820	COG1280	lysine exporter protein (LysE YggA)
BED33_RS01825	COG1280	lysine exporter protein (LysE YggA)
BED33_RS01830	COG0514	ATP-dependent DNA helicase (RecQ)
BED33_RS01835	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
BED33_RS01840	COG2050	protein possibly involved in aromatic compounds catabolism
BED33_RS01855	COG5564	TIM-barrel signal transduction protein
BED33_RS01860	COG5441	Belongs to the UPF0261 family
BED33_RS01870	COG0210	DNA helicase
BED33_RS01875	COG1011	Hydrolase
BED33_RS01880	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
BED33_RS01885	COG3159	Protein conserved in bacteria
BED33_RS01890	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BED33_RS01900	COG1965	Belongs to the frataxin family
BED33_RS01910	COG3072	Adenylate cyclase
BED33_RS01915	COG0181	hydroxymethylbilane synthase activity
BED33_RS01920	COG1587	Uroporphyrinogen-III synthase
BED33_RS01925	COG2959	enzyme of heme biosynthesis
BED33_RS01930	COG3071	HemY protein
BED33_RS01975	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
BED33_RS01980	COG2244	polysaccharide biosynthetic process
BED33_RS01985	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BED33_RS01990	COG0456	acetyltransferase
BED33_RS01995	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
BED33_RS02000	COG1088	dTDP-glucose 4,6-dehydratase activity
BED33_RS02005	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
BED33_RS02010	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
BED33_RS02015	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
BED33_RS02020	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BED33_RS02030	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
BED33_RS02035	COG3118	belongs to the thioredoxin family
BED33_RS02045	COG0248	Ppx GppA phosphatase
BED33_RS02060	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BED33_RS02090	COG3177	Filamentation induced by cAMP protein fic
BED33_RS02125	COG0582	viral genome integration into host DNA
BED33_RS02130	COG2207	Transcriptional regulator
BED33_RS02130	COG1609	Transcriptional regulator
BED33_RS02135	COG4214	carbohydrate transport
BED33_RS02145	COG4213	ABC transporter substrate-binding protein
BED33_RS02150	COG2115	Belongs to the xylose isomerase family
BED33_RS02155	COG1070	Carbohydrate kinase
BED33_RS02160	COG3121	Chaperone
BED33_RS02175	COG3274	enterobacterial common antigen metabolic process
BED33_RS02185	COG3276	selenocysteine insertion sequence binding
BED33_RS02190	COG1921	L-seryl-tRNASec selenium transferase activity
BED33_RS02195	COG3058	Necessary for formate dehydrogenase activity
BED33_RS02200	COG2864	formate dehydrogenase
BED33_RS02205	COG0437	4 iron, 4 sulfur cluster binding
BED33_RS02210	COG0243	molybdopterin cofactor binding
BED33_RS02210	COG3383	formate dehydrogenase (NAD+) activity
BED33_RS02215	COG0243	molybdopterin cofactor binding
BED33_RS02215	COG3383	formate dehydrogenase (NAD+) activity
BED33_RS02220	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
BED33_RS02225	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BED33_RS02230	COG0840	transmembrane signaling receptor activity
BED33_RS02235	COG2258	MOSC domain
BED33_RS02255	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BED33_RS02265	COG3722	fumarate hydratase activity
BED33_RS02270	COG0246	Mannitol dehydrogenase
BED33_RS02275	COG2213	PTS system mannitol-specific
BED33_RS02275	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
BED33_RS02285	COG0751	glycine-tRNA ligase activity
BED33_RS02290	COG0752	glycyl-tRNA synthetase alpha subunit
BED33_RS02295	COG2818	Glycosylase
BED33_RS02300	COG0456	acetyltransferase
BED33_RS02330	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BED33_RS02335	COG0366	Alpha amylase catalytic
BED33_RS02340	COG3977	Valine--pyruvate aminotransferase
BED33_RS02345	COG0569	domain protein
BED33_RS02345	COG2985	domain, Protein
BED33_RS02355	COG2814	Major facilitator Superfamily
BED33_RS02375	COG3152	Membrane
BED33_RS02385	COG0149	triose-phosphate isomerase activity
BED33_RS02395	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
BED33_RS02405	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
BED33_RS02410	COG3678	ATP-independent chaperone mediated protein folding
BED33_RS02415	COG0745	RESPONSE REGULATOR receiver
BED33_RS02420	COG2205	protein histidine kinase activity
BED33_RS02425	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BED33_RS02425	COG2169	Transcriptional regulator
BED33_RS02430	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
BED33_RS02435	COG1045	serine acetyltransferase
BED33_RS02440	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BED33_RS02445	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
BED33_RS02450	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
BED33_RS02455	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BED33_RS02460	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
BED33_RS02465	COG4942	peptidase
BED33_RS02470	COG2861	carbohydrate metabolic process
BED33_RS02485	COG1063	alcohol dehydrogenase
BED33_RS02490	COG0156	8-amino-7-oxononanoate synthase activity
BED33_RS02495	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BED33_RS02500	COG0859	PFAM glycosyl transferase family 9
BED33_RS02505	COG0859	PFAM glycosyl transferase family 9
BED33_RS02510	COG1519	Transferase
BED33_RS02520	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BED33_RS02525	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BED33_RS02530	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BED33_RS02535	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BED33_RS02540	COG2003	Belongs to the UPF0758 family
BED33_RS02545	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BED33_RS02550	COG0756	dUTP diphosphatase activity
BED33_RS02555	COG1309	transcriptional regulator
BED33_RS02560	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
BED33_RS02565	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
BED33_RS02570	COG1561	YicC-like family, N-terminal region
BED33_RS02575	COG0582	viral genome integration into host DNA
BED33_RS02595	COG3561	AntA/AntB antirepressor
BED33_RS02675	COG5001	Diguanylate cyclase
BED33_RS02680	COG1024	Enoyl-CoA hydratase
BED33_RS02685	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BED33_RS02700	COG2860	membrane
BED33_RS02715	COG1758	RNA polymerase activity
BED33_RS02720	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BED33_RS02725	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BED33_RS02730	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BED33_RS02735	COG0786	glutamate:sodium symporter activity
BED33_RS02740	COG2233	PERMEase
BED33_RS02745	COG2982	Protein involved in outer membrane biogenesis
BED33_RS02760	COG3423	Transcriptional regulator
BED33_RS02765	COG0456	acetyltransferase
BED33_RS02770	COG1490	D-aminoacyl-tRNA deacylase activity
BED33_RS02775	COG1295	ribonuclease BN
BED33_RS02780	COG1011	Hydrolase
BED33_RS02800	COG3852	Histidine kinase
BED33_RS02810	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BED33_RS02815	COG3078	GTPase activator activity
BED33_RS02820	COG0218	Necessary for normal cell division and for the maintenance of normal septation
BED33_RS02825	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BED33_RS02825	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BED33_RS02830	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BED33_RS02835	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
BED33_RS02840	COG3084	Protein conserved in bacteria
BED33_RS02850	COG1763	Mo-molybdopterin cofactor biosynthetic process
BED33_RS02885	COG2186	Transcriptional regulator
BED33_RS02890	COG0477	Major facilitator Superfamily
BED33_RS02895	COG1609	Transcriptional regulator
BED33_RS02900	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BED33_RS02905	COG1879	ABC-type sugar transport system periplasmic component
BED33_RS02910	COG1172	Belongs to the binding-protein-dependent transport system permease family
BED33_RS02920	COG1869	D-ribose catabolic process
BED33_RS02925	COG3158	transport of potassium into the cell
BED33_RS02930	COG0714	Associated with various cellular activities
BED33_RS02935	COG2425	protein containing a von Willebrand factor type A (vWA) domain
BED33_RS02945	COG2502	aspartate--ammonia ligase
BED33_RS02950	COG1522	sequence-specific DNA binding
BED33_RS02955	COG0716	FMN binding
BED33_RS02960	COG0445	tRNA wobble uridine modification
BED33_RS02965	COG0357	Ribosomal RNA small subunit methyltransferase G
BED33_RS02970	COG3312	ion transport
BED33_RS02975	COG0356	it plays a direct role in the translocation of protons across the membrane
BED33_RS02985	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BED33_RS02990	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BED33_RS02995	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BED33_RS03000	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BED33_RS03005	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BED33_RS03010	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BED33_RS03015	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BED33_RS03025	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BED33_RS03030	COG0573	inorganic phosphate transmembrane transporter activity
BED33_RS03035	COG0581	inorganic phosphate transmembrane transporter activity
BED33_RS03045	COG0704	Plays a role in the regulation of phosphate uptake
BED33_RS03055	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BED33_RS03065	COG0765	amino acid transport
BED33_RS03070	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BED33_RS03075	COG2252	PERMEase
BED33_RS03085	COG4566	intracellular signal transduction
BED33_RS03095	COG0431	NADPH-dependent FMN reductase
BED33_RS03100	COG0840	transmembrane signaling receptor activity
BED33_RS03105	COG2011	ABC-type metal ion transport system permease component
BED33_RS03120	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
BED33_RS03125	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BED33_RS03130	COG0706	membrane insertase activity
BED33_RS03140	COG0594	ribonuclease P activity
BED33_RS03145	COG0230	Belongs to the bacterial ribosomal protein bL34 family
BED33_RS03150	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BED33_RS03155	COG0592	DNA-directed DNA polymerase activity
BED33_RS03160	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BED33_RS03165	COG0187	DNA topoisomerase II activity
BED33_RS03170	COG0561	phosphatase activity
BED33_RS03175	COG2423	ornithine cyclodeaminase activity
BED33_RS03185	COG0823	Involved in the tonB-independent uptake of proteins
BED33_RS03190	COG5645	(Lipo)protein
BED33_RS03220	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BED33_RS03230	COG3074	FtsZ-dependent cytokinesis
BED33_RS03235	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BED33_RS03240	COG1575	Belongs to the MenA family. Type 1 subfamily
BED33_RS03245	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
BED33_RS03250	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
BED33_RS03255	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
BED33_RS03260	COG1609	Transcriptional regulator
BED33_RS03265	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BED33_RS03270	COG0254	rRNA binding
BED33_RS03275	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
BED33_RS03280	COG0626	cystathionine gamma-synthase activity
BED33_RS03285	COG0527	aspartate kinase activity
BED33_RS03285	COG0460	homoserine dehydrogenase
BED33_RS03295	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
BED33_RS03310	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BED33_RS03315	COG0165	Argininosuccinate lyase
BED33_RS03320	COG1629	transport
BED33_RS03370	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
BED33_RS03370	COG0678	peroxiredoxin activity
BED33_RS03380	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BED33_RS03385	COG1309	transcriptional regulator
BED33_RS03395	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BED33_RS03405	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
BED33_RS03445	COG1879	ABC-type sugar transport system periplasmic component
BED33_RS03450	COG1129	ABC transporter
BED33_RS03455	COG1172	Belongs to the binding-protein-dependent transport system permease family
BED33_RS03460	COG1172	Belongs to the binding-protein-dependent transport system permease family
BED33_RS03465	COG0583	DNA-binding transcription factor activity
BED33_RS03470	COG3085	chromosome segregation
BED33_RS03485	COG3978	acetolactate synthase activity
BED33_RS03490	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BED33_RS03495	COG0129	dihydroxy-acid dehydratase activity
BED33_RS03515	COG0583	DNA-binding transcription factor activity
BED33_RS03520	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
BED33_RS03545	COG3121	Chaperone
BED33_RS03565	COG3121	Chaperone
BED33_RS03575	COG1940	carbohydrate kinase activity
BED33_RS03580	COG1609	Transcriptional regulator
BED33_RS03605	COG3328	transposase activity
BED33_RS03615	COG3210	domain, Protein
BED33_RS03645	COG3851	Histidine kinase
BED33_RS03650	COG2197	response regulator
BED33_RS03655	COG2194	sulfuric ester hydrolase activity
BED33_RS03660	COG1764	response to oxidative stress
BED33_RS03670	COG0747	negative chemotaxis
BED33_RS03675	COG0601	transmembrane transport
BED33_RS03680	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BED33_RS03685	COG0444	Belongs to the ABC transporter superfamily
BED33_RS03690	COG4608	Belongs to the ABC transporter superfamily
BED33_RS03695	COG2194	sulfuric ester hydrolase activity
BED33_RS03715	COG1192	Involved in chromosome partitioning
BED33_RS03720	COG1215	transferase activity, transferring glycosyl groups
BED33_RS03725	COG1215	transferase activity, transferring glycosyl groups
BED33_RS03730	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
BED33_RS03735	COG3118	belongs to the thioredoxin family
BED33_RS03735	COG0457	Tetratricopeptide repeat
BED33_RS03745	COG2199	diguanylate cyclase activity
BED33_RS03745	COG2200	EAL domain
BED33_RS03750	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
BED33_RS03765	COG1301	dicarboxylic acid transport
BED33_RS03770	COG0612	Peptidase, M16
BED33_RS03775	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BED33_RS03780	COG1942	4-Oxalocrotonate Tautomerase
BED33_RS03785	COG2200	EAL domain
BED33_RS03795	COG2134	cdp-diacylglycerol pyrophosphatase
BED33_RS03800	COG1295	ribonuclease BN
BED33_RS03810	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BED33_RS03815	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
BED33_RS03825	COG0742	ribosomal rna small subunit methyltransferase
BED33_RS03840	COG0589	response to stress
BED33_RS03855	COG0306	phosphate transporter
BED33_RS03860	COG2081	HI0933 family
BED33_RS03905	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BED33_RS03925	COG1301	dicarboxylic acid transport
BED33_RS03940	COG3799	methylaspartate ammonia-lyase activity
BED33_RS03945	COG4865	methylaspartate mutase activity
BED33_RS03965	COG1648	precorrin-2 dehydrogenase activity
BED33_RS03965	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BED33_RS03970	COG0583	DNA-binding transcription factor activity
BED33_RS03975	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
BED33_RS03975	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
BED33_RS03985	COG0561	phosphatase activity
BED33_RS03995	COG0583	DNA-binding transcription factor activity
BED33_RS04000	COG2814	Major facilitator Superfamily
BED33_RS04010	COG3718	enzyme involved in inositol metabolism
BED33_RS04020	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BED33_RS04030	COG0673	inositol 2-dehydrogenase activity
BED33_RS04035	COG1082	Xylose isomerase domain protein TIM barrel
BED33_RS04040	COG1247	-acetyltransferase
BED33_RS04045	COG1741	Belongs to the pirin family
BED33_RS04050	COG1609	Transcriptional regulator
BED33_RS04055	COG2610	gluconate transmembrane transporter activity
BED33_RS04060	COG3265	gluconokinase activity
BED33_RS04065	COG2095	MarC family integral membrane protein
BED33_RS04070	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BED33_RS04090	COG3275	phosphorelay sensor kinase activity
BED33_RS04095	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
BED33_RS04100	COG1523	belongs to the glycosyl hydrolase 13 family
BED33_RS04110	COG0297	glycogen (starch) synthase activity
BED33_RS04115	COG0058	SHG alpha-glucan phosphorylase activity
BED33_RS04120	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
BED33_RS04135	COG1349	DNA-binding transcription factor activity
BED33_RS04140	COG0705	Rhomboid family
BED33_RS04155	COG2909	trisaccharide binding
BED33_RS04160	COG0058	SHG alpha-glucan phosphorylase activity
BED33_RS04165	COG1640	4-alpha-glucanotransferase
BED33_RS04170	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
BED33_RS04170	COG0316	Belongs to the HesB IscA family
BED33_RS04180	COG0596	Alpha beta hydrolase
BED33_RS04200	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
BED33_RS04205	COG1918	ferrous iron import across plasma membrane
BED33_RS04210	COG2183	response to ionizing radiation
BED33_RS04235	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BED33_RS04250	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
BED33_RS04260	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
BED33_RS04265	COG1011	Hydrolase
BED33_RS04275	COG0494	nUDIX hydrolase
BED33_RS04280	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
BED33_RS04305	COG4796	Type ii and iii secretion system protein
BED33_RS04310	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BED33_RS04330	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BED33_RS04340	COG0180	Tryptophanyl-tRNA synthetase
BED33_RS04345	COG1648	precorrin-2 dehydrogenase activity
BED33_RS04345	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BED33_RS04360	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BED33_RS04365	COG0402	S-adenosylhomocysteine deaminase activity
BED33_RS04370	COG0738	Major facilitator superfamily
BED33_RS04380	COG1486	melibiose metabolic process
BED33_RS04385	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BED33_RS04390	COG0433	COG0433 Predicted ATPase
BED33_RS04415	COG1765	OsmC-like protein
BED33_RS04420	COG3954	Phosphoribulokinase
BED33_RS04425	COG3089	Belongs to the UPF0270 family
BED33_RS04430	COG0429	hydrolase of the alpha beta-hydrolase fold
BED33_RS04445	COG4521	taurine ABC transporter
BED33_RS04455	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BED33_RS04460	COG2175	clavaminate synthase activity
BED33_RS04470	COG1216	Glycosyl transferase, family 2
BED33_RS04475	COG0488	(ABC) transporter
BED33_RS04480	COG2249	NAD(P)H dehydrogenase (quinone) activity
BED33_RS04490	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
BED33_RS04495	COG1047	Peptidyl-prolyl cis-trans
BED33_RS04500	COG2900	Belongs to the SlyX family
BED33_RS04505	COG0545	Peptidyl-prolyl cis-trans isomerase
BED33_RS04510	COG2964	Protein conserved in bacteria
BED33_RS04515	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
BED33_RS04520	COG2923	Belongs to the DsrF TusC family
BED33_RS04525	COG2168	tRNA wobble position uridine thiolation
BED33_RS04530	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BED33_RS04535	COG0049	tRNA binding
BED33_RS04545	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BED33_RS04560	COG0051	transcription antitermination factor activity, RNA binding
BED33_RS04565	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BED33_RS04570	COG0088	Forms part of the polypeptide exit tunnel
BED33_RS04575	COG0089	rRNA binding
BED33_RS04580	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BED33_RS04585	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BED33_RS04590	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
BED33_RS04595	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BED33_RS04600	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BED33_RS04605	COG0255	Belongs to the universal ribosomal protein uL29 family
BED33_RS04610	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BED33_RS04615	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BED33_RS04620	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BED33_RS04625	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BED33_RS04630	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BED33_RS04640	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BED33_RS04645	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BED33_RS04650	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
BED33_RS04655	COG1841	ribosomal large subunit assembly
BED33_RS04660	COG0200	Binds to the 23S rRNA
BED33_RS04665	COG0201	protein transport
BED33_RS04670	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BED33_RS04675	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BED33_RS04680	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BED33_RS04685	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BED33_RS04690	COG0202	RNA polymerase activity
BED33_RS04695	COG0203	ribosomal protein L17
BED33_RS04705	COG0789	Transcriptional regulator
BED33_RS04710	COG3036	rescue of stalled ribosome
BED33_RS04720	COG1970	mechanosensitive ion channel activity
BED33_RS04730	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BED33_RS04730	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BED33_RS04735	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BED33_RS04740	COG0242	peptide deformylase activity
BED33_RS04745	COG0758	DNA mediated transformation
BED33_RS04755	COG0551	DNA topoisomerase type I activity
BED33_RS04760	COG0009	L-threonylcarbamoyladenylate synthase
BED33_RS04765	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BED33_RS04770	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
BED33_RS04805	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
BED33_RS04810	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
BED33_RS04815	COG2224	Isocitrate lyase
BED33_RS04820	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
BED33_RS04825	COG1414	Transcriptional regulator
BED33_RS04850	COG0527	aspartate kinase activity
BED33_RS04855	COG0166	Belongs to the GPI family
BED33_RS04870	COG3833	ABC-type maltose transport systems, permease component
BED33_RS04880	COG2182	Extracellular solute-binding protein
BED33_RS04890	COG4580	involved in the transport of maltose and maltodextrins
BED33_RS04905	COG3161	chorismate lyase activity
BED33_RS04910	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
BED33_RS04915	COG2937	Belongs to the GPAT DAPAT family
BED33_RS04920	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
BED33_RS04925	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BED33_RS04930	COG3237	CsbD-like
BED33_RS04935	COG0735	belongs to the Fur family
BED33_RS04940	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
BED33_RS04940	COG2755	lipolytic protein G-D-S-L family
BED33_RS04945	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BED33_RS04975	COG1448	Aminotransferase
BED33_RS04980	COG2315	Protein conserved in bacteria
BED33_RS04985	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BED33_RS04995	COG3550	peptidyl-serine autophosphorylation
BED33_RS05010	COG2252	PERMEase
BED33_RS05015	COG0025	NhaP-type Na H and K H
BED33_RS05020	COG0583	DNA-binding transcription factor activity
BED33_RS05025	COG1380	Effector of murein hydrolase LrgA
BED33_RS05035	COG1126	abc transporter atp-binding protein
BED33_RS05040	COG0765	amino acid transport
BED33_RS05045	COG4597	amino acid ABC transporter
BED33_RS05050	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BED33_RS05065	COG1560	Kdo2-lipid A biosynthetic process
BED33_RS05070	COG0471	metal ion transport
BED33_RS05075	COG1278	Cold shock
BED33_RS05080	COG1278	Cold shock
BED33_RS05085	COG3133	Outer membrane lipoprotein
BED33_RS05095	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
BED33_RS05100	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BED33_RS05105	COG2264	protein methyltransferase activity
BED33_RS05110	COG4145	pantothenate transmembrane transporter activity
BED33_RS05115	COG3924	membrane
BED33_RS05120	COG0439	Biotin carboxylase
BED33_RS05125	COG0511	ligase activity, forming carbon-carbon bonds
BED33_RS05130	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BED33_RS05135	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
BED33_RS05145	COG0604	alcohol dehydrogenase
BED33_RS05150	COG2199	diguanylate cyclase activity
BED33_RS05150	COG2200	EAL domain
BED33_RS05155	COG1077	Cell shape determining protein MreB Mrl
BED33_RS05160	COG1792	Involved in formation and maintenance of cell shape
BED33_RS05165	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
BED33_RS05170	COG0424	maF-like protein
BED33_RS05175	COG1530	ribonuclease E activity
BED33_RS05180	COG3164	Protein of unknown function
BED33_RS05185	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BED33_RS05190	COG0312	modulator of DNA gyrase
BED33_RS05245	COG0583	DNA-binding transcription factor activity
BED33_RS05255	COG1566	PFAM secretion protein HlyD family protein
BED33_RS05260	COG1289	transmembrane transporter activity
BED33_RS05275	COG2732	(Barnase) inhibitor
BED33_RS05280	COG3028	Belongs to the UPF0307 family
BED33_RS05285	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
BED33_RS05425	COG5301	cellulose 1,4-beta-cellobiosidase activity
BED33_RS05460	COG0312	modulator of DNA gyrase
BED33_RS05470	COG3783	Cytochrome b(562)
BED33_RS05475	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BED33_RS05505	COG3964	amidohydrolase
BED33_RS05525	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BED33_RS05525	COG3711	transcriptional antiterminator
BED33_RS05530	COG3093	addiction module antidote protein HigA
BED33_RS05555	COG0366	Alpha amylase catalytic
BED33_RS05575	COG2308	Evidence 4 Homologs of previously reported genes of
BED33_RS05585	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
BED33_RS05590	COG0540	Belongs to the ATCase OTCase family
BED33_RS05595	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BED33_RS05600	COG1660	Displays ATPase and GTPase activities
BED33_RS05615	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
BED33_RS05620	COG1137	ATPase activity
BED33_RS05625	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
BED33_RS05630	COG3117	lipopolysaccharide transmembrane transporter activity
BED33_RS05635	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
BED33_RS05640	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
BED33_RS05640	COG0517	IMP dehydrogenase activity
BED33_RS05650	COG1127	ABC transporter
BED33_RS05655	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BED33_RS05660	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BED33_RS05665	COG2854	intermembrane phospholipid transfer
BED33_RS05670	COG3113	response to antibiotic
BED33_RS05675	COG5007	Belongs to the BolA IbaG family
BED33_RS05680	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BED33_RS05685	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BED33_RS05690	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BED33_RS05695	COG3105	Protein conserved in bacteria
BED33_RS05700	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
BED33_RS05705	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BED33_RS05710	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BED33_RS05715	COG0625	glutathione transferase activity
BED33_RS05720	COG2969	positive regulation of protein catabolic process
BED33_RS05735	COG0493	'glutamate synthase
BED33_RS05740	COG0069	glutamate synthase activity
BED33_RS05740	COG0067	glutamate synthase
BED33_RS05740	COG0070	glutamate synthase
BED33_RS05745	COG1242	4 iron, 4 sulfur cluster binding
BED33_RS05750	COG5002	protein histidine kinase activity
BED33_RS05750	COG2198	Histidine kinase
BED33_RS05750	COG0784	Response regulator, receiver
BED33_RS05755	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
BED33_RS05760	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BED33_RS05765	COG2823	Periplasmic or secreted lipoprotein
BED33_RS05770	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
BED33_RS05775	COG0792	nuclease activity
BED33_RS05785	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
BED33_RS05840	COG3121	Chaperone
BED33_RS05845	COG3188	usher protein
BED33_RS05860	COG0667	Aldo Keto reductase
BED33_RS05865	COG1064	alcohol dehydrogenase
BED33_RS05870	COG1741	Belongs to the pirin family
BED33_RS05875	COG0583	DNA-binding transcription factor activity
BED33_RS05880	COG0435	Glutathione S-transferase
BED33_RS05885	COG2259	Doxx family
BED33_RS05895	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
BED33_RS05900	COG4575	ribosome binding
BED33_RS05915	COG0586	Pfam SNARE associated Golgi protein
BED33_RS05930	COG2271	Major facilitator Superfamily
BED33_RS05935	COG1904	glucuronate isomerase
BED33_RS05940	COG0246	Mannitol dehydrogenase
BED33_RS05945	COG2721	sulfolactate sulfo-lyase activity
BED33_RS05955	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
BED33_RS05960	COG0861	Integral membrane protein TerC family
BED33_RS05970	COG0673	inositol 2-dehydrogenase activity
BED33_RS05975	COG1451	nucleotide metabolic process
BED33_RS05995	COG2813	Specifically methylates the guanine in position
BED33_RS06005	COG1902	pentaerythritol trinitrate reductase activity
BED33_RS06005	COG0446	pyridine nucleotide-disulphide oxidoreductase
BED33_RS06015	COG3247	response to pH
BED33_RS06025	COG0076	glutamate decarboxylase activity
BED33_RS06030	COG0531	amino acid
BED33_RS06040	COG1263	PTS System
BED33_RS06040	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BED33_RS06045	COG3328	transposase activity
BED33_RS06050	COG1263	PTS System
BED33_RS06050	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BED33_RS06055	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
BED33_RS06065	COG1472	Belongs to the glycosyl hydrolase 3 family
BED33_RS06075	COG3876	Protein conserved in bacteria
BED33_RS06095	COG0358	DNA primase activity
BED33_RS06100	COG0828	Belongs to the bacterial ribosomal protein bS21 family
BED33_RS06105	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BED33_RS06110	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
BED33_RS06115	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BED33_RS06120	COG1968	undecaprenyl-diphosphatase activity
BED33_RS06125	COG0617	tRNA 3'-terminal CCA addition
BED33_RS06130	COG4991	sh3 domain protein
BED33_RS06135	COG3025	triphosphatase activity
BED33_RS06140	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
BED33_RS06145	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
BED33_RS06145	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
BED33_RS06150	COG0531	amino acid
BED33_RS06160	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BED33_RS06165	COG3384	dioxygenase
BED33_RS06170	COG0754	glutathionylspermidine amidase activity
BED33_RS06175	COG5463	Belongs to the UPF0441 family
BED33_RS06185	COG1538	Outer membrane efflux protein
BED33_RS06190	COG0494	nUDIX hydrolase
BED33_RS06195	COG3151	Protein conserved in bacteria
BED33_RS06200	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
BED33_RS06205	COG3150	esterase
BED33_RS06220	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
BED33_RS06225	COG2249	NAD(P)H dehydrogenase (quinone) activity
BED33_RS06230	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BED33_RS06240	COG2132	Multicopper oxidase
BED33_RS06250	COG0656	L-ascorbic acid biosynthetic process
BED33_RS06255	COG1979	alcohol dehydrogenase
BED33_RS06260	COG2207	Transcriptional regulator
BED33_RS06265	COG0586	Pfam SNARE associated Golgi protein
BED33_RS06270	COG0626	cystathionine gamma-synthase activity
BED33_RS06280	COG0848	biopolymer transport protein
BED33_RS06330	COG4964	Belongs to the GSP D family
BED33_RS06355	COG3145	DNA-N1-methyladenine dioxygenase activity
BED33_RS06360	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BED33_RS06370	COG2135	peptidase activity
BED33_RS06390	COG2963	transposase activity
BED33_RS06410	COG0577	efflux transmembrane transporter activity
BED33_RS06410	COG1136	(ABC) transporter
BED33_RS06425	COG2801	Transposase and inactivated derivatives
BED33_RS06445	COG1120	ATPase activity
BED33_RS06450	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BED33_RS06455	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BED33_RS06460	COG4592	Periplasmic binding protein
BED33_RS06470	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BED33_RS06475	COG0840	transmembrane signaling receptor activity
BED33_RS06490	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BED33_RS06525	COG1677	Flagellar hook-basal body complex protein FliE
BED33_RS06570	COG1815	bacterial-type flagellum-dependent cell motility
BED33_RS06575	COG1558	bacterial-type flagellum-dependent cell motility
BED33_RS06580	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
BED33_RS06595	COG4786	Flagellar basal body rod
BED33_RS06605	COG1706	bacterial-type flagellum-dependent cell motility
BED33_RS06640	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BED33_RS06645	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
BED33_RS06650	COG1516	flagellar protein fliS
BED33_RS06670	COG1191	sigma factor activity
BED33_RS06675	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
BED33_RS06685	COG3133	Outer membrane lipoprotein
BED33_RS06690	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
BED33_RS06695	COG0437	4 iron, 4 sulfur cluster binding
BED33_RS06700	COG5557	Pfam Polysulphide reductase, NrfD
BED33_RS06705	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
BED33_RS06710	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
BED33_RS06715	COG1773	rubredoxin
BED33_RS06725	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
BED33_RS06730	COG0298	carbon dioxide binding
BED33_RS06735	COG0409	Hydrogenase expression formation protein
BED33_RS06740	COG0309	Hydrogenase expression formation protein (HypE)
BED33_RS06745	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
BED33_RS06755	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
BED33_RS06770	COG5001	Diguanylate cyclase
BED33_RS06790	COG0477	Major facilitator Superfamily
BED33_RS06805	COG1283	sodium-dependent phosphate transmembrane transporter activity
BED33_RS06815	COG1609	Transcriptional regulator
BED33_RS06825	COG0477	Major facilitator Superfamily
BED33_RS06830	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BED33_RS06850	COG4607	ABC-type enterochelin transport system periplasmic component
BED33_RS06860	COG4605	iron ion homeostasis
BED33_RS06865	COG4604	ABC transporter, ATP-binding protein
BED33_RS06870	COG0024	Methionine aminopeptidase
BED33_RS06895	COG1289	transmembrane transporter activity
BED33_RS06905	COG1982	Orn Lys Arg decarboxylase major
BED33_RS06910	COG0531	amino acid
BED33_RS06950	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
BED33_RS06965	COG1982	Orn Lys Arg decarboxylase major
BED33_RS06975	COG0741	lytic transglycosylase activity
BED33_RS06980	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
BED33_RS06985	COG1194	a g-specific adenine glycosylase
BED33_RS06990	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BED33_RS06995	COG3171	Protein conserved in bacteria
BED33_RS07010	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BED33_RS07015	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BED33_RS07020	COG1872	DUF167
BED33_RS07025	COG0762	integral membrane protein
BED33_RS07030	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BED33_RS07035	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BED33_RS07040	COG2805	Type II/IV secretion system protein
BED33_RS07050	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BED33_RS07055	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BED33_RS07060	COG1678	Uncharacterized ACR, COG1678
BED33_RS07065	COG0189	ligase activity
BED33_RS07070	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BED33_RS07075	COG2356	endonuclease I
BED33_RS07080	COG3091	SprT-like family
BED33_RS07085	COG0640	Transcriptional regulator
BED33_RS07090	COG3328	transposase activity
BED33_RS07105	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BED33_RS07110	COG1166	arginine decarboxylase activity
BED33_RS07120	COG0501	Belongs to the peptidase M48B family
BED33_RS07125	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
BED33_RS07130	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BED33_RS07135	COG0126	phosphoglycerate kinase activity
BED33_RS07140	COG0191	fructose-bisphosphate aldolase activity
BED33_RS07160	COG1279	arginine transmembrane transporter activity
BED33_RS07170	COG0583	DNA-binding transcription factor activity
BED33_RS07175	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
BED33_RS07180	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BED33_RS07215	COG0602	queuosine metabolic process
BED33_RS07235	COG0720	synthase
BED33_RS07240	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BED33_RS07245	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BED33_RS07250	COG0175	sulfate reduction
BED33_RS07265	COG2234	aminopeptidase activity
BED33_RS07270	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BED33_RS07270	COG1648	precorrin-2 dehydrogenase activity
BED33_RS07275	COG0175	sulfate reduction
BED33_RS07280	COG2895	sulfate adenylyltransferase (ATP) activity
BED33_RS07285	COG0529	Catalyzes the synthesis of activated sulfate
BED33_RS07295	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
BED33_RS07305	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
BED33_RS07310	COG0585	pseudouridine synthase activity
BED33_RS07315	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
BED33_RS07320	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BED33_RS07325	COG1388	LysM domain
BED33_RS07325	COG4942	peptidase
BED33_RS07330	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BED33_RS07335	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BED33_RS07360	COG3188	usher protein
BED33_RS07365	COG3121	Chaperone
BED33_RS07375	COG3539	Fimbrial protein
BED33_RS07380	COG3539	Fimbrial protein
BED33_RS07410	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BED33_RS07420	COG1538	Outer membrane efflux protein
BED33_RS07440	COG1028	Short-chain dehydrogenase reductase Sdr
BED33_RS07445	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BED33_RS07450	COG1858	cytochrome C peroxidase
BED33_RS07460	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BED33_RS07465	COG0640	Transcriptional regulator
BED33_RS07520	COG0410	ABC transporter
BED33_RS07525	COG1137	ATPase activity
BED33_RS07530	COG4177	L-phenylalanine transmembrane transporter activity
BED33_RS07545	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
BED33_RS07545	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
BED33_RS07550	COG0243	molybdopterin cofactor binding
BED33_RS07555	COG0437	4 iron, 4 sulfur cluster binding
BED33_RS07560	COG3302	dmso reductase anchor subunit
BED33_RS07565	COG3381	protein complex oligomerization
BED33_RS07585	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BED33_RS07590	COG2137	regulation of response to DNA damage stimulus
BED33_RS07595	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BED33_RS07600	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
BED33_RS07620	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BED33_RS07625	COG1238	metal cluster binding
BED33_RS07630	COG2918	glutathione biosynthetic process
BED33_RS07635	COG1854	S-ribosylhomocysteine lyase activity
BED33_RS07640	COG4536	flavin adenine dinucleotide binding
BED33_RS07655	COG4137	Cytochrome C assembly protein
BED33_RS07660	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BED33_RS07665	COG0228	four-way junction DNA binding
BED33_RS07670	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BED33_RS07675	COG0336	Belongs to the RNA methyltransferase TrmD family
BED33_RS07680	COG0335	large ribosomal subunit rRNA binding
BED33_RS07690	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
BED33_RS07695	COG3279	Response regulator of the LytR AlgR family
BED33_RS07700	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BED33_RS07705	COG0287	Prephenate dehydrogenase
BED33_RS07705	COG1605	Chorismate mutase
BED33_RS07710	COG1605	Chorismate mutase
BED33_RS07710	COG0077	Prephenate dehydratase
BED33_RS07720	COG0542	response to heat
BED33_RS07730	COG0564	pseudouridine synthase activity
BED33_RS07735	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BED33_RS07745	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
BED33_RS07750	COG3328	transposase activity
BED33_RS07785	COG5544	Lipoprotein
BED33_RS07790	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BED33_RS07795	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BED33_RS07795	COG1042	CoA-binding domain protein
BED33_RS07795	COG0045	succinate-CoA ligase (ADP-forming) activity
BED33_RS07800	COG3148	PFAM DTW domain containing protein
BED33_RS07805	COG3118	belongs to the thioredoxin family
BED33_RS07810	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BED33_RS07815	COG2814	Major facilitator Superfamily
BED33_RS07820	COG1566	PFAM secretion protein HlyD family protein
BED33_RS07825	COG1538	Outer membrane efflux protein
BED33_RS07830	COG1846	Transcriptional regulator
BED33_RS07840	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
BED33_RS07845	COG2814	Major facilitator Superfamily
BED33_RS07880	COG0765	amino acid transport
BED33_RS07885	COG0765	amino acid transport
BED33_RS07895	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BED33_RS07910	COG0436	Aminotransferase
BED33_RS07915	COG0582	viral genome integration into host DNA
BED33_RS07970	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BED33_RS08050	COG1484	DNA-dependent DNA replication
BED33_RS08150	COG5410	chromosome segregation
BED33_RS08285	COG0235	Class ii aldolase
BED33_RS08290	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
BED33_RS08295	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
BED33_RS08300	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
BED33_RS08305	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
BED33_RS08325	COG1960	acyl-CoA dehydrogenase activity
BED33_RS08335	COG0121	glutamine amidotransferase
BED33_RS08340	COG3034	peptidoglycan biosynthetic process
BED33_RS08345	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
BED33_RS08350	COG1805	sodium ion transport
BED33_RS08355	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
BED33_RS08360	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
BED33_RS08370	COG2871	sodium ion transport
BED33_RS08375	COG1477	protein flavinylation
BED33_RS08380	COG2991	Protein conserved in bacteria
BED33_RS08390	COG1181	Belongs to the D-alanine--D-alanine ligase family
BED33_RS08395	COG2964	Protein conserved in bacteria
BED33_RS08410	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BED33_RS08415	COG2195	Cleaves the N-terminal amino acid of tripeptides
BED33_RS08420	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
BED33_RS08430	COG1073	alpha beta
BED33_RS08440	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BED33_RS08445	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
BED33_RS08450	COG2188	Transcriptional regulator
BED33_RS08470	COG3459	Glycosyltransferase 36 associated
BED33_RS08485	COG2226	methyltransferase
BED33_RS08510	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BED33_RS08515	COG3123	guanosine phosphorylase activity
BED33_RS08520	COG2974	May be involved in recombination
BED33_RS08525	COG1940	carbohydrate kinase activity
BED33_RS08530	COG0419	ATPase involved in DNA repair
BED33_RS08535	COG0420	3'-5' exonuclease activity
BED33_RS08540	COG0745	RESPONSE REGULATOR receiver
BED33_RS08545	COG5002	protein histidine kinase activity
BED33_RS08565	COG0366	Alpha amylase catalytic
BED33_RS08585	COG0450	alkyl hydroperoxide reductase
BED33_RS08590	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
BED33_RS08595	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
BED33_RS08605	COG0343	queuine tRNA-ribosyltransferase activity
BED33_RS08610	COG1862	Preprotein translocase
BED33_RS08615	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BED33_RS08620	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BED33_RS08635	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BED33_RS08640	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BED33_RS08640	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BED33_RS08645	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
BED33_RS08650	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BED33_RS08655	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
BED33_RS08660	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
BED33_RS08670	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BED33_RS08675	COG0142	geranyltranstransferase activity
BED33_RS08685	COG0301	tRNA thio-modification
BED33_RS08685	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BED33_RS08695	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BED33_RS08700	COG1666	GTP binding
BED33_RS08705	COG2814	Major facilitator Superfamily
BED33_RS08710	COG0109	protoheme IX farnesyltransferase activity
BED33_RS08715	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
BED33_RS08720	COG1845	cytochrome c oxidase, subunit III
BED33_RS08725	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BED33_RS08730	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BED33_RS08740	COG2223	nitrite transmembrane transporter activity
BED33_RS08745	COG3056	Lipoprotein
BED33_RS08750	COG0271	Belongs to the BolA IbaG family
BED33_RS08760	COG0544	peptidyl-prolyl cis-trans isomerase activity
BED33_RS08765	COG0740	serine-type endopeptidase activity
BED33_RS08770	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BED33_RS08775	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BED33_RS08780	COG0776	regulation of translation
BED33_RS08785	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BED33_RS08790	COG1555	photosystem II stabilization
BED33_RS08795	COG0824	Thioesterase
BED33_RS08800	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
BED33_RS08805	COG4533	DNA binding
BED33_RS08810	COG0561	phosphatase activity
BED33_RS08820	COG1522	sequence-specific DNA binding
BED33_RS08825	COG1132	(ABC) transporter
BED33_RS08830	COG1132	(ABC) transporter
BED33_RS08835	COG0347	Belongs to the P(II) protein family
BED33_RS08840	COG0004	ammonium transporteR
BED33_RS08845	COG1946	Acyl-CoA thioesterase
BED33_RS08850	COG3126	Type III secretion system lipoprotein chaperone (YscW)
BED33_RS08855	COG3695	enzyme binding
BED33_RS08885	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BED33_RS08890	COG0803	Belongs to the bacterial solute-binding protein 9 family
BED33_RS08895	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BED33_RS08900	COG0254	rRNA binding
BED33_RS08915	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
BED33_RS08920	COG3457	Alanine racemase
BED33_RS08930	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BED33_RS08935	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BED33_RS08940	COG1309	transcriptional regulator
BED33_RS08945	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
BED33_RS08965	COG2832	Protein of unknown function (DUF454)
BED33_RS08970	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BED33_RS08980	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
BED33_RS08985	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BED33_RS08990	COG0326	Molecular chaperone. Has ATPase activity
BED33_RS08995	COG0563	adenylate kinase activity
BED33_RS09000	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
BED33_RS09005	COG2244	polysaccharide biosynthetic process
BED33_RS09010	COG1442	glycosyl transferase family 8
BED33_RS09010	COG1216	Glycosyl transferase, family 2
BED33_RS09015	COG1215	transferase activity, transferring glycosyl groups
BED33_RS09020	COG0438	transferase activity, transferring glycosyl groups
BED33_RS09025	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BED33_RS09030	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BED33_RS09050	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BED33_RS09055	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BED33_RS09055	COG4651	solute:proton antiporter activity
BED33_RS09060	COG2223	nitrite transmembrane transporter activity
BED33_RS09065	COG0737	Belongs to the 5'-nucleotidase family
BED33_RS09075	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BED33_RS09080	COG3735	TraB family
BED33_RS09085	COG2217	Heavy metal translocating P-type atpase
BED33_RS09090	COG0789	Transcriptional regulator
BED33_RS09095	COG1585	Membrane protein implicated in regulation of membrane protease activity
BED33_RS09100	COG0330	HflC and HflK could
BED33_RS09105	COG3118	belongs to the thioredoxin family
BED33_RS09110	COG0300	oxidoreductase activity
BED33_RS09115	COG2755	lipolytic protein G-D-S-L family
BED33_RS09120	COG4181	ATPase activity
BED33_RS09125	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
BED33_RS09130	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
BED33_RS09135	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BED33_RS09140	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BED33_RS09145	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BED33_RS09150	COG0215	cysteine-tRNA ligase activity
BED33_RS09155	COG2501	S4 domain
BED33_RS09160	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BED33_RS09170	COG0582	viral genome integration into host DNA
BED33_RS09220	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BED33_RS09285	COG1484	DNA-dependent DNA replication
BED33_RS09445	COG4386	tail sheath protein
BED33_RS09510	COG0582	viral genome integration into host DNA
BED33_RS09635	COG0305	Participates in initiation and elongation during chromosome replication
BED33_RS09685	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
BED33_RS09725	COG3772	lysozyme
BED33_RS09890	COG0582	viral genome integration into host DNA
BED33_RS09895	COG0582	viral genome integration into host DNA
BED33_RS09900	COG0582	viral genome integration into host DNA
BED33_RS09915	COG3177	Filamentation induced by cAMP protein fic
BED33_RS10000	COG2850	peptidyl-arginine hydroxylation
BED33_RS10015	COG5265	(ABC) transporter
BED33_RS10030	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
BED33_RS10045	COG1278	Cold shock
BED33_RS10060	COG3706	GGDEF domain
BED33_RS10065	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BED33_RS10070	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
BED33_RS10075	COG0321	lipoyl(octanoyl) transferase activity
BED33_RS10080	COG2921	Belongs to the UPF0250 family
BED33_RS10085	COG1686	Belongs to the peptidase S11 family
BED33_RS10090	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
BED33_RS10095	COG0772	Belongs to the SEDS family
BED33_RS10100	COG0768	penicillin binding
BED33_RS10110	COG0799	negative regulation of ribosome biogenesis
BED33_RS10115	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BED33_RS10120	COG1466	dna polymerase III delta subunit
BED33_RS10125	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
BED33_RS10130	COG0495	leucyl-tRNA aminoacylation
BED33_RS10135	COG2888	peptidyl-tyrosine sulfation
BED33_RS10140	COG1126	abc transporter atp-binding protein
BED33_RS10145	COG0765	amino acid transport
BED33_RS10150	COG0765	amino acid transport
BED33_RS10165	COG0815	Transfers the fatty acyl group on membrane lipoproteins
BED33_RS10170	COG4535	Mg2 and Co2 transporter CorC
BED33_RS10175	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
BED33_RS10180	COG1702	phosphate starvation-inducible protein PhoH
BED33_RS10185	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BED33_RS10190	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BED33_RS10225	COG0367	asparagine synthase
BED33_RS10230	COG0647	UMP catabolic process
BED33_RS10235	COG1940	carbohydrate kinase activity
BED33_RS10235	COG1846	Transcriptional regulator
BED33_RS10240	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BED33_RS10245	COG0363	glucosamine-6-phosphate deaminase activity
BED33_RS10255	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BED33_RS10275	COG0735	belongs to the Fur family
BED33_RS10285	COG0840	transmembrane signaling receptor activity
BED33_RS10295	COG0596	Alpha beta hydrolase
BED33_RS10300	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
BED33_RS10305	COG0033	Phosphoglucomutase
BED33_RS10320	COG0745	RESPONSE REGULATOR receiver
BED33_RS10325	COG2205	protein histidine kinase activity
BED33_RS10330	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
BED33_RS10335	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
BED33_RS10340	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
BED33_RS10360	COG2994	toxin metabolic process
BED33_RS10370	COG3272	Protein of unknown function (DUF1722)
BED33_RS10380	COG5212	phosphodiesterase
BED33_RS10385	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
BED33_RS10390	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
BED33_RS10395	COG1984	allophanate hydrolase subunit 2
BED33_RS10400	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
BED33_RS10415	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
BED33_RS10425	COG2009	succinate dehydrogenase
BED33_RS10430	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
BED33_RS10435	COG1053	succinate dehydrogenase
BED33_RS10445	COG0567	Dehydrogenase, E1 component
BED33_RS10450	COG0508	dehydrogenase complex catalyzes the overall conversion of
BED33_RS10455	COG0045	succinate-CoA ligase (ADP-forming) activity
BED33_RS10460	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BED33_RS10465	COG0737	Belongs to the 5'-nucleotidase family
BED33_RS10470	COG1271	oxidase subunit
BED33_RS10475	COG1294	oxidase, subunit
BED33_RS10480	COG4890	Cyd operon protein YbgT
BED33_RS10485	COG3790	cyd operon protein YbgE
BED33_RS10490	COG0824	Thioesterase
BED33_RS10495	COG0811	peptide transport
BED33_RS10500	COG0848	biopolymer transport protein
BED33_RS10505	COG3064	Membrane
BED33_RS10505	COG3064	Membrane
BED33_RS10510	COG0823	Involved in the tonB-independent uptake of proteins
BED33_RS10515	COG2885	chlorophyll binding
BED33_RS10520	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
BED33_RS10545	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
BED33_RS10555	COG1230	cation diffusion facilitator family transporter
BED33_RS10560	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BED33_RS10565	COG0588	phosphoglycerate mutase activity
BED33_RS10590	COG2017	converts alpha-aldose to the beta-anomer
BED33_RS10595	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
BED33_RS10600	COG1085	galactose-1-phosphate uridylyltransferase
BED33_RS10605	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BED33_RS10615	COG1119	ATPase activity
BED33_RS10620	COG3585	molybdate ion transport
BED33_RS10620	COG2005	Transcriptional regulator
BED33_RS10630	COG0725	ABC transporter, periplasmic molybdate-binding protein
BED33_RS10635	COG4149	molybdate abc transporter
BED33_RS10645	COG0561	phosphatase activity
BED33_RS10650	COG2706	6-phosphogluconolactonase activity
BED33_RS10660	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
BED33_RS10665	COG0156	8-amino-7-oxononanoate synthase activity
BED33_RS10670	COG2226	methyltransferase
BED33_RS10685	COG0556	nucleotide-excision repair
BED33_RS10690	COG4628	conserved protein (DUF2132)
BED33_RS10695	COG0391	Required for morphogenesis under gluconeogenic growth conditions
BED33_RS10700	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BED33_RS10705	COG0315	cyclic pyranopterin monophosphate synthase activity
BED33_RS10710	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
BED33_RS10715	COG0314	molybdopterin synthase activity
BED33_RS10720	COG0670	Belongs to the BI1 family
BED33_RS10725	COG0842	Transport permease protein
BED33_RS10730	COG0842	Transport permease protein
BED33_RS10735	COG1131	(ABC) transporter
BED33_RS10740	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BED33_RS10745	COG1309	transcriptional regulator
BED33_RS10750	COG0513	Belongs to the DEAD box helicase family
BED33_RS10755	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BED33_RS10765	COG2239	Acts as a magnesium transporter
BED33_RS10770	COG1686	Belongs to the peptidase S11 family
BED33_RS10775	COG0277	FAD linked oxidase domain protein
BED33_RS10795	COG2261	transglycosylase associated protein
BED33_RS10805	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
BED33_RS10820	COG4807	Protein conserved in bacteria
BED33_RS10840	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
BED33_RS10850	COG2897	thiosulfate sulfurtransferase activity
BED33_RS10865	COG1732	Glycine betaine
BED33_RS10875	COG1125	glycine betaine transport
BED33_RS10880	COG1174	glycine betaine transport
BED33_RS10895	COG0583	DNA-binding transcription factor activity
BED33_RS10905	COG0697	spore germination
BED33_RS10925	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BED33_RS10930	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BED33_RS10950	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
BED33_RS10960	COG1126	abc transporter atp-binding protein
BED33_RS10965	COG0765	amino acid transport
BED33_RS10970	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BED33_RS10975	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BED33_RS10980	COG0783	Belongs to the Dps family
BED33_RS10985	COG4106	trans-aconitate 2-methyltransferase activity
BED33_RS11000	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
BED33_RS11020	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
BED33_RS11040	COG0488	(ABC) transporter
BED33_RS11050	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BED33_RS11055	COG0303	'Molybdopterin
BED33_RS11070	COG1136	(ABC) transporter
BED33_RS11070	COG0577	efflux transmembrane transporter activity
BED33_RS11100	COG0583	DNA-binding transcription factor activity
BED33_RS11105	COG0477	Major facilitator Superfamily
BED33_RS11110	COG0302	gtp cyclohydrolase
BED33_RS11115	COG2311	Membrane
BED33_RS11140	COG3604	Transcriptional regulator
BED33_RS11150	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
BED33_RS11155	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
BED33_RS11165	COG3260	NADH ubiquinone oxidoreductase 20
BED33_RS11170	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BED33_RS11175	COG3261	NADH dehydrogenase
BED33_RS11175	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
BED33_RS11180	COG0651	ATP synthesis coupled electron transport
BED33_RS11185	COG4237	Hydrogenase 4 membrane
BED33_RS11190	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BED33_RS11195	COG0650	Formate hydrogenlyase subunit 4
BED33_RS11200	COG0651	ATP synthesis coupled electron transport
BED33_RS11205	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
BED33_RS11210	COG0375	protein maturation
BED33_RS11215	COG0298	carbon dioxide binding
BED33_RS11220	COG2949	membrane
BED33_RS11225	COG0281	malic enzyme
BED33_RS11240	COG1346	cytolysis
BED33_RS11245	COG1380	Effector of murein hydrolase LrgA
BED33_RS11250	COG2814	Major facilitator Superfamily
BED33_RS11270	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BED33_RS11270	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BED33_RS11275	COG0489	protein tyrosine kinase activity
BED33_RS11280	COG0572	uridine kinase
BED33_RS11290	COG2982	Protein involved in outer membrane biogenesis
BED33_RS11295	COG3069	C4-dicarboxylate transmembrane transporter activity
BED33_RS11300	COG1253	flavin adenine dinucleotide binding
BED33_RS11340	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BED33_RS11360	COG3328	transposase activity
BED33_RS11385	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BED33_RS11390	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BED33_RS11395	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
BED33_RS11400	COG0140	phosphoribosyl-ATP diphosphatase activity
BED33_RS11400	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BED33_RS11405	COG0107	imidazoleglycerol-phosphate synthase activity
BED33_RS11410	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
BED33_RS11420	COG0131	Imidazoleglycerol-phosphate dehydratase
BED33_RS11420	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
BED33_RS11425	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BED33_RS11435	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
BED33_RS11445	COG1172	Belongs to the binding-protein-dependent transport system permease family
BED33_RS11450	COG1129	ABC transporter
BED33_RS11455	COG0371	Dehydrogenase
BED33_RS11465	COG0531	amino acid
BED33_RS11470	COG2925	Exonuclease
BED33_RS11475	COG3320	Male sterility
BED33_RS11475	COG1022	Amp-dependent synthetase and ligase
BED33_RS11480	COG1289	transmembrane transporter activity
BED33_RS11485	COG2926	Belongs to the UPF0265 family
BED33_RS11495	COG1172	Belongs to the binding-protein-dependent transport system permease family
BED33_RS11500	COG1129	ABC transporter
BED33_RS11515	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BED33_RS11525	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BED33_RS11545	COG4656	Part of a membrane complex involved in electron transport
BED33_RS11555	COG1012	belongs to the aldehyde dehydrogenase family
BED33_RS11565	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
BED33_RS11650	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
BED33_RS11715	COG1492	cobalamin metabolic process
BED33_RS11735	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
BED33_RS11805	COG0137	argininosuccinate synthase activity
BED33_RS11810	COG0534	Mate efflux family protein
BED33_RS11820	COG0352	thiamine-phosphate diphosphorylase activity
BED33_RS11825	COG0561	phosphatase activity
BED33_RS11830	COG1349	DNA-binding transcription factor activity
BED33_RS11840	COG0835	chemotaxis
BED33_RS11840	COG0784	Response regulator, receiver
BED33_RS11870	COG3842	ATPase activity
BED33_RS11880	COG1840	ABC-type Fe3 transport system, periplasmic component
BED33_RS11885	COG2271	Major facilitator Superfamily
BED33_RS11900	COG4565	transcriptional regulatory protein
BED33_RS11905	COG3290	protein histidine kinase activity
BED33_RS11915	COG3290	protein histidine kinase activity
BED33_RS11920	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
BED33_RS11925	COG3052	prosthetic group binding
BED33_RS11930	COG2301	Belongs to the HpcH HpaI aldolase family
BED33_RS11935	COG3051	citrate lyase alpha subunit
BED33_RS11940	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
BED33_RS11940	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
BED33_RS11950	COG0471	metal ion transport
BED33_RS11965	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BED33_RS11985	COG2814	Major facilitator Superfamily
BED33_RS11990	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BED33_RS11990	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
BED33_RS11995	COG3122	Protein conserved in bacteria
BED33_RS12055	COG3228	Belongs to the MtfA family
BED33_RS12065	COG1070	Carbohydrate kinase
BED33_RS12090	COG3121	Chaperone
BED33_RS12100	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
BED33_RS12130	COG3321	synthase
BED33_RS12130	COG1028	Short-chain dehydrogenase reductase Sdr
BED33_RS12130	COG0604	alcohol dehydrogenase
BED33_RS12135	COG3328	transposase activity
BED33_RS12140	COG3250	beta-galactosidase activity
BED33_RS12145	COG1609	Transcriptional regulator
BED33_RS12160	COG0840	transmembrane signaling receptor activity
BED33_RS12175	COG1285	pathogenesis
BED33_RS12185	COG2130	NADP-dependent
BED33_RS12190	COG0589	response to stress
BED33_RS12210	COG1360	Flagellar Motor Protein
BED33_RS12215	COG0643	Histidine kinase
BED33_RS12215	COG2198	Histidine kinase
BED33_RS12220	COG0835	chemotaxis
BED33_RS12225	COG0840	transmembrane signaling receptor activity
BED33_RS12230	COG0840	transmembrane signaling receptor activity
BED33_RS12235	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
BED33_RS12245	COG0745	RESPONSE REGULATOR receiver
BED33_RS12250	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
BED33_RS12255	COG1404	Belongs to the peptidase S8 family
BED33_RS12255	COG4935	Belongs to the peptidase S8 family
BED33_RS12260	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BED33_RS12265	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BED33_RS12280	COG3418	PFAM FlgN family protein
BED33_RS12285	COG2747	anti-sigma28 factor FlgM
BED33_RS12295	COG1815	bacterial-type flagellum-dependent cell motility
BED33_RS12300	COG1558	bacterial-type flagellum-dependent cell motility
BED33_RS12305	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
BED33_RS12340	COG1256	bacterial-type flagellum assembly
BED33_RS12360	COG1338	Plays a role in the flagellum-specific transport system
BED33_RS12380	COG1580	Controls the rotational direction of flagella during chemotaxis
BED33_RS12400	COG1317	bacterial-type flagellum organization
BED33_RS12415	COG1677	Flagellar hook-basal body complex protein FliE
BED33_RS12420	COG0582	viral genome integration into host DNA
BED33_RS12440	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
BED33_RS12445	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
BED33_RS12485	COG1191	sigma factor activity
BED33_RS12495	COG2515	1-aminocyclopropane-1-carboxylate deaminase
BED33_RS12500	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BED33_RS12505	COG0765	amino acid transport
BED33_RS12510	COG1126	abc transporter atp-binding protein
BED33_RS12525	COG0506	proline dehydrogenase activity
BED33_RS12525	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
BED33_RS12525	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
BED33_RS12550	COG0672	)-iron permease
BED33_RS12555	COG2822	iron ion transport
BED33_RS12565	COG0655	NAD(P)H dehydrogenase (quinone) activity
BED33_RS12575	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
BED33_RS12590	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BED33_RS12595	COG0778	Nitroreductase
BED33_RS12600	COG2267	carboxylic ester hydrolase activity
BED33_RS12605	COG0251	oxidation-reduction process
BED33_RS12610	COG1335	isochorismatase
BED33_RS12615	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BED33_RS12620	COG1309	transcriptional regulator
BED33_RS12625	COG1113	amino acid transport
BED33_RS12635	COG0582	viral genome integration into host DNA
BED33_RS12640	COG2963	transposase activity
BED33_RS12650	COG2226	methyltransferase
BED33_RS12665	COG0366	Alpha amylase catalytic
BED33_RS12675	COG3136	membrane protein required for alginate biosynthesis
BED33_RS12690	COG0322	excinuclease ABC activity
BED33_RS12695	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BED33_RS12775	COG2963	transposase activity
BED33_RS12825	COG3772	lysozyme
BED33_RS12830	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
BED33_RS12835	COG2979	Protein of unknown function (DUF533)
BED33_RS12850	COG0012	GTP binding
BED33_RS12860	COG0193	aminoacyl-tRNA hydrolase activity
BED33_RS12875	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BED33_RS12885	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
BED33_RS12890	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
BED33_RS12895	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BED33_RS12900	COG2890	protein-(glutamine-N5) methyltransferase activity
BED33_RS12915	COG2877	3-deoxy-8-phosphooctulonate synthase activity
BED33_RS12920	COG0659	secondary active sulfate transmembrane transporter activity
BED33_RS12925	COG3706	GGDEF domain
BED33_RS12945	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BED33_RS12950	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
BED33_RS12955	COG3381	protein complex oligomerization
BED33_RS12965	COG0477	Major facilitator Superfamily
BED33_RS12980	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BED33_RS12990	COG0673	inositol 2-dehydrogenase activity
BED33_RS12995	COG0728	peptidoglycan biosynthetic process
BED33_RS13000	COG0387	Pfam Sodium calcium exchanger
BED33_RS13010	COG2814	Major facilitator Superfamily
BED33_RS13025	COG3850	Histidine kinase
BED33_RS13030	COG1294	oxidase, subunit
BED33_RS13035	COG1271	oxidase subunit
BED33_RS13040	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BED33_RS13045	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BED33_RS13050	COG3138	arginine N-succinyltransferase
BED33_RS13060	COG3724	N-succinylarginine dihydrolase activity
BED33_RS13065	COG2988	succinylglutamate desuccinylase activity
BED33_RS13095	COG1228	amidohydrolase
BED33_RS13105	COG0402	S-adenosylhomocysteine deaminase activity
BED33_RS13135	COG4942	peptidase
BED33_RS13145	COG2222	sugar isomerase
BED33_RS13150	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
BED33_RS13155	COG3716	PTS system mannose fructose sorbose family IID component
BED33_RS13165	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BED33_RS13175	COG1349	DNA-binding transcription factor activity
BED33_RS13195	COG1187	pseudouridine synthase activity
BED33_RS13200	COG0786	glutamate:sodium symporter activity
BED33_RS13220	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BED33_RS13225	COG2226	methyltransferase
BED33_RS13230	COG3788	relative of glutathione S-transferase, MAPEG superfamily
BED33_RS13235	COG1801	Protein of unknown function DUF72
BED33_RS13240	COG1335	isochorismatase
BED33_RS13245	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BED33_RS13250	COG0494	nUDIX hydrolase
BED33_RS13255	COG0217	transcriptional regulatory protein
BED33_RS13260	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
BED33_RS13265	COG0632	four-way junction helicase activity
BED33_RS13270	COG2255	four-way junction helicase activity
BED33_RS13275	COG3104	oligopeptide transport
BED33_RS13280	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BED33_RS13285	COG1121	(ABC) transporter
BED33_RS13290	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
BED33_RS13295	COG0739	heme binding
BED33_RS13300	COG1560	Kdo2-lipid A biosynthetic process
BED33_RS13315	COG0469	pyruvate kinase activity
BED33_RS13320	COG1737	Transcriptional regulator
BED33_RS13325	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BED33_RS13330	COG0800	Aldolase
BED33_RS13335	COG2076	Multidrug Resistance protein
BED33_RS13340	COG2076	Multidrug Resistance protein
BED33_RS13345	COG0251	oxidation-reduction process
BED33_RS13350	COG1199	ATP-dependent helicase activity
BED33_RS13365	COG0318	PFAM AMP-dependent synthetase and ligase
BED33_RS13370	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
BED33_RS13375	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
BED33_RS13380	COG2894	cell division
BED33_RS13385	COG0850	regulation of cytokinetic process
BED33_RS13395	COG3100	YcgL domain-containing protein
BED33_RS13400	COG2951	lytic endotransglycosylase activity
BED33_RS13405	COG0179	Fumarylacetoacetate (FAA) hydrolase
BED33_RS13410	COG2983	Belongs to the UPF0260 family
BED33_RS13435	COG0668	transmembrane transport
BED33_RS13440	COG0625	glutathione transferase activity
BED33_RS13465	COG4251	negative regulation of phosphorylation
BED33_RS13465	COG2203	Gaf domain
BED33_RS13465	COG5001	Diguanylate cyclase
BED33_RS13465	COG3706	GGDEF domain
BED33_RS13490	COG2814	Major facilitator Superfamily
BED33_RS13500	COG3008	intermembrane lipid transfer
BED33_RS13505	COG2995	paraquat-inducible protein a
BED33_RS13510	COG1956	GAF domain-containing protein
BED33_RS13520	COG0793	Belongs to the peptidase S41A family
BED33_RS13525	COG0501	Belongs to the peptidase M48B family
BED33_RS13540	COG0823	Involved in the tonB-independent uptake of proteins
BED33_RS13550	COG3023	N-Acetylmuramoyl-L-alanine amidase
BED33_RS13560	COG1988	membrane-bound metal-dependent
BED33_RS13570	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
BED33_RS13575	COG1653	transport
BED33_RS13580	COG3842	ATPase activity
BED33_RS13585	COG0395	ABC-type sugar transport system, permease component
BED33_RS13590	COG1175	transmembrane transport
BED33_RS13600	COG1028	Short-chain dehydrogenase reductase Sdr
BED33_RS13605	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
BED33_RS13610	COG1917	Cupin 2, conserved barrel domain protein
BED33_RS13615	COG3328	transposase activity
BED33_RS13620	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BED33_RS13630	COG0583	DNA-binding transcription factor activity
BED33_RS13635	COG0427	acetyl-CoA hydrolase
BED33_RS13640	COG1024	Enoyl-CoA hydratase
BED33_RS13645	COG1703	isobutyryl-CoA mutase activity
BED33_RS13655	COG3001	Fructosamine kinase
BED33_RS13660	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BED33_RS13665	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BED33_RS13670	COG1121	(ABC) transporter
BED33_RS13675	COG0803	Belongs to the bacterial solute-binding protein 9 family
BED33_RS13710	COG1811	Na channel or pump
BED33_RS13715	COG4249	Peptidase C14 caspase catalytic subunit p20
BED33_RS13720	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BED33_RS13725	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BED33_RS13730	COG0291	Belongs to the bacterial ribosomal protein bL35 family
BED33_RS13735	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
BED33_RS13740	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BED33_RS13750	COG0776	regulation of translation
BED33_RS13765	COG4139	cobalamin transport
BED33_RS13770	COG0386	Belongs to the glutathione peroxidase family
BED33_RS13775	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
BED33_RS13780	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BED33_RS13785	COG0463	Glycosyl transferase, family 2
BED33_RS13790	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BED33_RS13790	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BED33_RS13795	COG0726	polysaccharide deacetylase
BED33_RS13800	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
BED33_RS13805	COG2076	Multidrug Resistance protein
BED33_RS13810	COG2076	Multidrug Resistance protein
BED33_RS13815	COG0791	NLP P60 protein
BED33_RS13855	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
BED33_RS13860	COG0574	Belongs to the PEP-utilizing enzyme family
BED33_RS13860	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BED33_RS13870	COG0628	permease
BED33_RS13875	COG0277	FAD linked oxidase domain protein
BED33_RS13875	COG0247	lactate metabolic process
BED33_RS13880	COG2050	protein possibly involved in aromatic compounds catabolism
BED33_RS13885	COG0316	Belongs to the HesB IscA family
BED33_RS13890	COG0719	Fe-S assembly protein
BED33_RS13895	COG0396	ATPase activity
BED33_RS13900	COG0719	Fe-S assembly protein
BED33_RS13910	COG2166	iron-sulfur cluster assembly
BED33_RS13915	COG1388	LysM domain
BED33_RS13915	COG1376	ErfK ybiS ycfS ynhG family protein
BED33_RS13945	COG0307	riboflavin synthase, alpha
BED33_RS13950	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BED33_RS13955	COG2814	Major facilitator Superfamily
BED33_RS13960	COG0583	DNA-binding transcription factor activity
BED33_RS13965	COG1609	Transcriptional regulator
BED33_RS13975	COG0791	NLP P60 protein
BED33_RS13980	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
BED33_RS13985	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BED33_RS13995	COG0346	lactoylglutathione lyase activity
BED33_RS14005	COG1309	transcriptional regulator
BED33_RS14010	COG2194	sulfuric ester hydrolase activity
BED33_RS14015	COG3313	Fe-S protein
BED33_RS14020	COG4989	oxidoreductase activity
BED33_RS14025	COG1289	transmembrane transporter activity
BED33_RS14030	COG1566	PFAM secretion protein HlyD family protein
BED33_RS14040	COG1846	Transcriptional regulator
BED33_RS14045	COG3133	Outer membrane lipoprotein
BED33_RS14050	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
BED33_RS14055	COG3895	Periplasmic Protein
BED33_RS14060	COG0259	pyridoxamine-phosphate oxidase activity
BED33_RS14065	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BED33_RS14075	COG0625	glutathione transferase activity
BED33_RS14100	COG3104	oligopeptide transport
BED33_RS14110	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BED33_RS14110	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BED33_RS14120	COG4172	Belongs to the ABC transporter superfamily
BED33_RS14130	COG4171	peptide transport system, permease
BED33_RS14135	COG4168	peptide transport system, permease
BED33_RS14140	COG4166	transmembrane transport
BED33_RS14155	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
BED33_RS14160	COG1842	Phage shock protein A
BED33_RS14170	COG1983	PspC domain protein
BED33_RS14180	COG3106	COG3106 Predicted ATPase
BED33_RS14185	COG3768	UPF0283 membrane protein
BED33_RS14190	COG5654	RES domain protein
BED33_RS14195	COG5642	Protein of unknown function (DUF2384)
BED33_RS14205	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
BED33_RS14210	COG4948	Mandelate Racemase Muconate Lactonizing
BED33_RS14215	COG2866	Carboxypeptidase
BED33_RS14220	COG4166	transmembrane transport
BED33_RS14225	COG0598	Magnesium transport protein CorA
BED33_RS14230	COG0037	tRNA processing
BED33_RS14235	COG0823	Involved in the tonB-independent uptake of proteins
BED33_RS14250	COG1285	pathogenesis
BED33_RS14255	COG3042	response to heat
BED33_RS14260	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BED33_RS14265	COG2911	Protein conserved in bacteria
BED33_RS14275	COG3784	Protein of unknown function (DUF1318)
BED33_RS14280	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
BED33_RS14285	COG1643	Atp-dependent helicase
BED33_RS14300	COG3591	Belongs to the peptidase S1B family
BED33_RS14310	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
BED33_RS14315	COG2205	protein histidine kinase activity
BED33_RS14320	COG0745	RESPONSE REGULATOR receiver
BED33_RS14330	COG0531	amino acid
BED33_RS14345	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
BED33_RS14350	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
BED33_RS14355	COG0589	response to stress
BED33_RS14360	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BED33_RS14365	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BED33_RS14380	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
BED33_RS14385	COG1028	Short-chain dehydrogenase reductase Sdr
BED33_RS14395	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BED33_RS14400	COG3328	transposase activity
BED33_RS14410	COG1011	Hydrolase
BED33_RS14415	COG0440	acetolactate synthase activity
BED33_RS14420	COG0028	Belongs to the TPP enzyme family
BED33_RS14430	COG3023	N-Acetylmuramoyl-L-alanine amidase
BED33_RS14455	COG0625	glutathione transferase activity
BED33_RS14465	COG4221	oxidoreductase activity
BED33_RS14470	COG0583	DNA-binding transcription factor activity
BED33_RS14475	COG2814	Major facilitator Superfamily
BED33_RS14500	COG0114	fumarate hydratase activity
BED33_RS14510	COG5339	Protein conserved in bacteria
BED33_RS14520	COG1609	Transcriptional regulator
BED33_RS14525	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BED33_RS14525	COG1263	PTS System
BED33_RS14530	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
BED33_RS14535	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
BED33_RS14540	COG0385	Bile acid
BED33_RS14545	COG0673	inositol 2-dehydrogenase activity
BED33_RS14560	COG1129	ABC transporter
BED33_RS14565	COG1879	ABC-type sugar transport system periplasmic component
BED33_RS14575	COG2160	L-arabinose isomerase activity
BED33_RS14585	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BED33_RS14615	COG4657	Part of a membrane complex involved in electron transport
BED33_RS14625	COG4656	Part of a membrane complex involved in electron transport
BED33_RS14635	COG2207	Transcriptional regulator
BED33_RS14635	COG3708	Transcriptional regulator
BED33_RS14640	COG4658	electron transport chain
BED33_RS14645	COG4659	FMN binding
BED33_RS14655	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BED33_RS14730	COG0494	nUDIX hydrolase
BED33_RS14820	COG1484	DNA-dependent DNA replication
BED33_RS14905	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BED33_RS14925	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
BED33_RS14930	COG1966	Carbon starvation protein
BED33_RS14935	COG2879	small protein
BED33_RS14940	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BED33_RS14945	COG1349	DNA-binding transcription factor activity
BED33_RS14965	COG0023	Translation Initiation Factor
BED33_RS14970	COG0284	orotidine-5'-phosphate decarboxylase activity
BED33_RS14980	COG3135	benzoate transporter
BED33_RS14985	COG1396	sequence-specific DNA binding
BED33_RS14995	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
BED33_RS15000	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
BED33_RS15005	COG0671	phosphoesterase, PA-phosphatase related
BED33_RS15040	COG0616	signal peptide processing
BED33_RS15045	COG1028	Short-chain dehydrogenase reductase Sdr
BED33_RS15050	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
BED33_RS15060	COG1187	pseudouridine synthase activity
BED33_RS15065	COG0009	L-threonylcarbamoyladenylate synthase
BED33_RS15070	COG0613	PHP domain protein
BED33_RS15080	COG0512	Glutamine amidotransferase of anthranilate synthase
BED33_RS15090	COG0135	phosphoribosylanthranilate isomerase activity
BED33_RS15090	COG0134	indole-3-glycerol-phosphate synthase activity
BED33_RS15095	COG0133	tryptophan synthase activity
BED33_RS15100	COG0159	tryptophan synthase activity
BED33_RS15110	COG3047	cAMP biosynthetic process
BED33_RS15115	COG0727	PFAM Uncharacterised protein family (UPF0153)
BED33_RS15130	COG2917	probably involved in intracellular septation
BED33_RS15135	COG1607	acyl-coa hydrolase
BED33_RS15140	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
BED33_RS15145	COG2350	Protein conserved in bacteria
BED33_RS15160	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BED33_RS15165	COG3099	Belongs to the UPF0263 family
BED33_RS15175	COG0444	Belongs to the ABC transporter superfamily
BED33_RS15180	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BED33_RS15200	COG2095	MarC family integral membrane protein
BED33_RS15205	COG1454	alcohol dehydrogenase
BED33_RS15205	COG1012	belongs to the aldehyde dehydrogenase family
BED33_RS15220	COG2916	Histone family protein nucleoid-structuring protein H-NS
BED33_RS15230	COG0745	RESPONSE REGULATOR receiver
BED33_RS15235	COG1752	Esterase of the alpha-beta hydrolase superfamily
BED33_RS15245	COG3012	SEC-C Motif Domain Protein
BED33_RS15250	COG0788	formyltetrahydrofolate deformylase activity
BED33_RS15265	COG0583	DNA-binding transcription factor activity
BED33_RS15270	COG0708	Exodeoxyribonuclease III
BED33_RS15275	COG0494	nUDIX hydrolase
BED33_RS15285	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BED33_RS15295	COG0778	Nitroreductase
BED33_RS15300	COG0616	signal peptide processing
BED33_RS15305	COG0252	asparaginase activity
BED33_RS15310	COG1335	isochorismatase
BED33_RS15325	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BED33_RS15340	COG3713	MltA-interacting MipA family protein
BED33_RS15345	COG2766	serine protein kinase
BED33_RS15350	COG2718	Belongs to the UPF0229 family
BED33_RS15365	COG0583	DNA-binding transcription factor activity
BED33_RS15375	COG2202	Pas domain
BED33_RS15375	COG2199	diguanylate cyclase activity
BED33_RS15375	COG2200	EAL domain
BED33_RS15385	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BED33_RS15390	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BED33_RS15395	COG2719	SpoVR family
BED33_RS15400	COG2186	Transcriptional regulator
BED33_RS15405	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
BED33_RS15410	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
BED33_RS15430	COG3142	Participates in the control of copper homeostasis
BED33_RS15435	COG3102	Protein conserved in bacteria
BED33_RS15440	COG0018	arginyl-trna synthetase
BED33_RS15450	COG1702	phosphate starvation-inducible protein PhoH
BED33_RS15465	COG3658	cytochrome
BED33_RS15470	COG1215	transferase activity, transferring glycosyl groups
BED33_RS15485	COG0006	proline dipeptidase activity
BED33_RS15490	COG4114	ferric iron reductase
BED33_RS15495	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BED33_RS15520	COG0577	efflux transmembrane transporter activity
BED33_RS15520	COG1136	(ABC) transporter
BED33_RS15530	COG0577	efflux transmembrane transporter activity
BED33_RS15530	COG1136	(ABC) transporter
BED33_RS15545	COG0672	)-iron permease
BED33_RS15560	COG2066	Belongs to the glutaminase family
BED33_RS15565	COG3622	Belongs to the hyi family
BED33_RS15570	COG0235	Class ii aldolase
BED33_RS15575	COG3395	kinase activity
BED33_RS15580	COG1349	DNA-binding transcription factor activity
BED33_RS15585	COG3290	protein histidine kinase activity
BED33_RS15590	COG4565	transcriptional regulatory protein
BED33_RS15595	COG3493	citrate carrier protein
BED33_RS15615	COG2223	nitrite transmembrane transporter activity
BED33_RS15620	COG0561	phosphatase activity
BED33_RS15630	COG3328	transposase activity
BED33_RS15635	COG0500	methyltransferase
BED33_RS15640	COG3328	transposase activity
BED33_RS15685	COG4974	Belongs to the 'phage' integrase family
BED33_RS15695	COG1276	copper resistance
BED33_RS15700	COG2372	response to copper ion
BED33_RS15705	COG1528	Iron-storage protein
BED33_RS15720	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BED33_RS15725	COG1770	oligopeptidase
BED33_RS15735	COG3097	Belongs to the UPF0267 family
BED33_RS15740	COG3141	response to X-ray
BED33_RS15745	COG0513	Belongs to the DEAD box helicase family
BED33_RS15750	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
BED33_RS15755	COG3140	Belongs to the UPF0181 family
BED33_RS15765	COG0494	nUDIX hydrolase
BED33_RS15770	COG1760	l-serine dehydratase
BED33_RS15780	COG1253	flavin adenine dinucleotide binding
BED33_RS15785	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
BED33_RS15785	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BED33_RS15790	COG3715	PTS system
BED33_RS15795	COG3716	PTS system mannose fructose sorbose family IID component
BED33_RS15800	COG4811	Protein of unknown function (DUF986)
BED33_RS15805	COG1971	Probably functions as a manganese efflux pump
BED33_RS15815	COG3447	MASE1 domain protein
BED33_RS15815	COG5001	Diguanylate cyclase
BED33_RS15815	COG5002	protein histidine kinase activity
BED33_RS15825	COG2226	methyltransferase
BED33_RS15830	COG0768	penicillin binding
BED33_RS15835	COG1496	oxidoreductase activity
BED33_RS15885	COG2207	Transcriptional regulator
BED33_RS15905	COG1132	(ABC) transporter
BED33_RS15925	COG2203	Gaf domain
BED33_RS15925	COG3706	GGDEF domain
BED33_RS15925	COG4251	negative regulation of phosphorylation
BED33_RS15925	COG5001	Diguanylate cyclase
BED33_RS15940	COG3755	Protein conserved in bacteria
BED33_RS15965	COG1733	regulation of RNA biosynthetic process
BED33_RS15970	COG0702	epimerase
BED33_RS15975	COG2873	o-acetylhomoserine
BED33_RS15995	COG0840	transmembrane signaling receptor activity
BED33_RS16015	COG2211	Major facilitator Superfamily
BED33_RS16030	COG0538	isocitrate dehydrogenase activity
BED33_RS16060	COG0538	isocitrate dehydrogenase activity
BED33_RS16065	COG1187	pseudouridine synthase activity
BED33_RS16075	COG0482	sulfurtransferase activity
BED33_RS16080	COG2915	High frequency lysogenization protein hflD homolog
BED33_RS16085	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BED33_RS16095	COG0745	RESPONSE REGULATOR receiver
BED33_RS16125	COG4591	ABC-type transport system involved in lipoprotein release permease component
BED33_RS16135	COG4591	ABC-type transport system involved in lipoprotein release permease component
BED33_RS16140	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BED33_RS16145	COG3134	Outer membrane lipoprotein
BED33_RS16150	COG1252	NADH dehydrogenase
BED33_RS16155	COG3150	esterase
BED33_RS16160	COG1472	Belongs to the glycosyl hydrolase 3 family
BED33_RS16170	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
BED33_RS16175	COG5633	Lipoprotein
BED33_RS16180	COG0537	adenosine 5'-monophosphoramidase activity
BED33_RS16185	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BED33_RS16195	COG0641	radical SAM
BED33_RS16215	COG1263	PTS System
BED33_RS16215	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BED33_RS16220	COG0084	hydrolase, TatD family'
BED33_RS16225	COG0470	DNA polymerase III
BED33_RS16230	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BED33_RS16235	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BED33_RS16240	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BED33_RS16245	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BED33_RS16255	COG1028	Short-chain dehydrogenase reductase Sdr
BED33_RS16260	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BED33_RS16265	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BED33_RS16270	COG0416	fatty acid biosynthetic process
BED33_RS16275	COG0333	Belongs to the bacterial ribosomal protein bL32 family
BED33_RS16280	COG1399	metal-binding, possibly nucleic acid-binding protein
BED33_RS16285	COG0424	maF-like protein
BED33_RS16290	COG0564	pseudouridine synthase activity
BED33_RS16295	COG1530	ribonuclease E activity
BED33_RS16300	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
BED33_RS16305	COG0418	dihydroorotase activity
BED33_RS16330	COG0628	permease
BED33_RS16335	COG1054	Belongs to the UPF0176 family
BED33_RS16365	COG1560	Kdo2-lipid A biosynthetic process
BED33_RS16375	COG2259	Doxx family
BED33_RS16385	COG2814	Major facilitator Superfamily
BED33_RS16395	COG2943	transferase activity, transferring hexosyl groups
BED33_RS16400	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
BED33_RS16420	COG3263	regulation of cellular component size
BED33_RS16430	COG3916	Acyl-homoserine-lactone synthase
BED33_RS16435	COG2771	luxR family
BED33_RS16440	COG4235	cytochrome complex assembly
BED33_RS16450	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BED33_RS16460	COG3301	Polysulphide reductase, NrfD
BED33_RS16465	COG0437	4 iron, 4 sulfur cluster binding
BED33_RS16470	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
BED33_RS16485	COG2920	part of a sulfur-relay system
BED33_RS16490	COG1254	Belongs to the acylphosphatase family
BED33_RS16505	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BED33_RS16510	COG3785	DNA binding
BED33_RS16515	COG1832	CoA-binding protein
BED33_RS16525	COG1803	Methylglyoxal synthase
BED33_RS16530	COG0210	DNA helicase
BED33_RS16535	COG3304	Inner membrane component domain
BED33_RS16540	COG1289	transmembrane transporter activity
BED33_RS16545	COG3070	regulator of competence-specific genes
BED33_RS16560	COG3120	sequence-specific DNA binding
BED33_RS16565	COG1067	ATP-dependent peptidase activity
BED33_RS16570	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BED33_RS16580	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BED33_RS16585	COG3009	Protein conserved in bacteria
BED33_RS16590	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BED33_RS16590	COG3008	intermembrane lipid transfer
BED33_RS16595	COG2995	paraquat-inducible protein a
BED33_RS16600	COG0488	(ABC) transporter
BED33_RS16605	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BED33_RS16605	COG0116	Belongs to the methyltransferase superfamily
BED33_RS16610	COG0633	Ferredoxin
BED33_RS16610	COG3217	Mosc domain protein beta barrel domain protein
BED33_RS16620	COG0167	dihydroorotate dehydrogenase activity
BED33_RS16625	COG0308	aminopeptidase N
BED33_RS16630	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
BED33_RS16635	COG0017	Asparaginyl-tRNA synthetase
BED33_RS16645	COG1448	Aminotransferase
BED33_RS16655	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BED33_RS16660	COG3108	Peptidase M15
BED33_RS16665	COG2989	Protein conserved in bacteria
BED33_RS16670	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
BED33_RS16680	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
BED33_RS16685	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BED33_RS16690	COG1434	Gram-negative-bacterium-type cell wall biogenesis
BED33_RS16695	COG3173	Aminoglycoside phosphotransferase
BED33_RS16700	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
BED33_RS16705	COG2835	tetraacyldisaccharide 4'-kinase activity
BED33_RS16710	COG1278	Cold shock
BED33_RS16720	COG5383	Protein conserved in bacteria
BED33_RS16725	COG1663	tetraacyldisaccharide 4'-kinase activity
BED33_RS16735	COG0658	competence protein
BED33_RS16735	COG2333	competence protein COMEC
BED33_RS16740	COG0776	regulation of translation
BED33_RS16745	COG0539	negative regulation of cytoplasmic translation
BED33_RS16750	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BED33_RS16755	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BED33_RS16760	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
BED33_RS16765	COG2323	membrane
BED33_RS16770	COG0252	asparaginase activity
BED33_RS16775	COG1944	ATP diphosphatase activity
BED33_RS16780	COG2116	formate transmembrane transporter activity
BED33_RS16785	COG1882	Formate acetyltransferase
BED33_RS16790	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
BED33_RS16795	COG2814	Major facilitator Superfamily
BED33_RS16800	COG3328	transposase activity
BED33_RS16815	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BED33_RS16820	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BED33_RS16825	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
BED33_RS16830	COG3107	peptidoglycan biosynthetic process
BED33_RS16830	COG1674	ftsk spoiiie
BED33_RS16835	COG1522	sequence-specific DNA binding
BED33_RS16840	COG0492	ferredoxin-NADP+ reductase activity
BED33_RS16850	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
BED33_RS16855	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
BED33_RS16860	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BED33_RS16865	COG0542	response to heat
BED33_RS16870	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
BED33_RS16875	COG1278	Cold shock
BED33_RS16885	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BED33_RS16890	COG2990	Protein conserved in bacteria
BED33_RS16895	COG3593	DNA synthesis involved in DNA repair
BED33_RS16900	COG2431	L-lysine efflux transmembrane transporter activity
BED33_RS16905	COG1151	hydroxylamine reductase activity
BED33_RS16910	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
BED33_RS16915	COG0028	Belongs to the TPP enzyme family
BED33_RS16925	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
BED33_RS16930	COG0702	epimerase
BED33_RS16935	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BED33_RS16945	COG1126	abc transporter atp-binding protein
BED33_RS16950	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BED33_RS16955	COG4215	(ABC) transporter
BED33_RS16960	COG4160	amino acid transport
BED33_RS16965	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BED33_RS16970	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BED33_RS16980	COG1177	transmembrane transport
BED33_RS16985	COG1176	ABC-type spermidine putrescine transport system, permease component I
BED33_RS16990	COG3842	ATPase activity
BED33_RS16995	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
BED33_RS17015	COG2985	domain, Protein
BED33_RS17015	COG0569	domain protein
BED33_RS17025	COG0671	phosphoesterase, PA-phosphatase related
BED33_RS17030	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
BED33_RS17035	COG1349	DNA-binding transcription factor activity
BED33_RS17040	COG0814	amino acid
BED33_RS17045	COG1760	l-serine dehydratase
BED33_RS17055	COG1686	Belongs to the peptidase S11 family
BED33_RS17065	COG0626	cystathionine gamma-synthase activity
BED33_RS17070	COG2011	ABC-type metal ion transport system permease component
BED33_RS17095	COG0625	glutathione transferase activity
BED33_RS17100	COG4771	TonB-dependent receptor
BED33_RS17110	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BED33_RS17115	COG0833	amino acid
BED33_RS17120	COG0583	DNA-binding transcription factor activity
BED33_RS17135	COG2855	membrane
BED33_RS17140	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
BED33_RS17165	COG3710	Transcriptional regulator
BED33_RS17170	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BED33_RS17170	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
BED33_RS17170	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BED33_RS17175	COG1105	Belongs to the carbohydrate kinase PfkB family
BED33_RS17190	COG3005	denitrification pathway
BED33_RS17195	COG0243	molybdopterin cofactor binding
BED33_RS17210	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BED33_RS17215	COG1312	Catalyzes the dehydration of D-mannonate
BED33_RS17225	COG0246	Mannitol dehydrogenase
BED33_RS17230	COG2186	Transcriptional regulator
BED33_RS17240	COG0523	cobalamin synthesis protein
BED33_RS17245	COG0671	phosphoesterase, PA-phosphatase related
BED33_RS17250	COG0791	NLP P60 protein
BED33_RS17260	COG2200	EAL domain
BED33_RS17265	COG4166	transmembrane transport
BED33_RS17270	COG4174	ABC transporter (Permease)
BED33_RS17275	COG4239	(ABC) transporter, permease
BED33_RS17280	COG4172	Belongs to the ABC transporter superfamily
BED33_RS17290	COG2814	Major facilitator Superfamily
BED33_RS17295	COG1187	pseudouridine synthase activity
BED33_RS17300	COG1061	Type III restriction enzyme res subunit
BED33_RS17305	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
BED33_RS17310	COG3081	Nucleoid-associated protein
BED33_RS17315	COG3082	Protein of unknown function (DUF1414)
BED33_RS17340	COG3328	transposase activity
BED33_RS17355	COG2801	Transposase and inactivated derivatives
BED33_RS17375	COG2723	6-phospho-beta-galactosidase activity
BED33_RS17380	COG2190	(PTS) system
BED33_RS17380	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BED33_RS17380	COG1263	PTS System
BED33_RS17385	COG1737	Transcriptional regulator
BED33_RS17440	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BED33_RS17455	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
BED33_RS17470	COG2223	nitrite transmembrane transporter activity
BED33_RS17475	COG2198	Histidine kinase
BED33_RS17475	COG0642	Histidine kinase
BED33_RS17480	COG2197	response regulator
BED33_RS17485	COG2205	protein histidine kinase activity
BED33_RS17485	COG0784	Response regulator, receiver
BED33_RS17495	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BED33_RS17500	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BED33_RS17515	COG4574	serine-type endopeptidase inhibitor activity
BED33_RS17535	COG0814	amino acid
BED33_RS17555	COG1441	menaquinone biosynthetic process
BED33_RS17560	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
BED33_RS17565	COG0596	Alpha beta hydrolase
BED33_RS17570	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
BED33_RS17575	COG1169	isochorismate synthase
BED33_RS17580	COG4575	ribosome binding
BED33_RS17585	COG0129	dihydroxy-acid dehydratase activity
BED33_RS17590	COG4702	Belongs to the UPF0303 family
BED33_RS17600	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BED33_RS17605	COG1609	Transcriptional regulator
BED33_RS17610	COG1028	Short-chain dehydrogenase reductase Sdr
BED33_RS17615	COG3265	gluconokinase activity
BED33_RS17635	COG1007	ATP synthesis coupled electron transport
BED33_RS17640	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BED33_RS17645	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BED33_RS17650	COG0713	ATP synthesis coupled electron transport
BED33_RS17655	COG0839	Belongs to the complex I subunit 6 family
BED33_RS17660	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BED33_RS17665	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
BED33_RS17670	COG1034	ATP synthesis coupled electron transport
BED33_RS17685	COG0649	NAD binding
BED33_RS17685	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BED33_RS17690	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BED33_RS17695	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BED33_RS17700	COG0583	DNA-binding transcription factor activity
BED33_RS17705	COG0436	Aminotransferase
BED33_RS17710	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
BED33_RS17715	COG0471	metal ion transport
BED33_RS17715	COG0490	domain, Protein
BED33_RS17725	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BED33_RS17730	COG3013	Belongs to the UPF0304 family
BED33_RS17735	COG3092	negative regulation of chromosome organization
BED33_RS17745	COG0857	belongs to the CobB CobQ family
BED33_RS17745	COG0280	phosphate acetyltransferase
BED33_RS17750	COG1609	Transcriptional regulator
BED33_RS17755	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BED33_RS17765	COG3037	sugar-specific permease SgaT UlaA
BED33_RS17775	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
BED33_RS17790	COG1090	epimerase
BED33_RS17800	COG4598	ABC transporter
BED33_RS17805	COG4160	amino acid transport
BED33_RS17810	COG4215	(ABC) transporter
BED33_RS17815	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BED33_RS17820	COG0163	prenyltransferase activity
BED33_RS17825	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
BED33_RS17830	COG1286	toxin biosynthetic process
BED33_RS17835	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
BED33_RS17840	COG0285	dihydrofolate synthase activity
BED33_RS17845	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
BED33_RS17850	COG0586	Pfam SNARE associated Golgi protein
BED33_RS17860	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BED33_RS17865	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BED33_RS17880	COG0697	spore germination
BED33_RS17885	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BED33_RS17890	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BED33_RS17915	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
BED33_RS17925	COG1609	Transcriptional regulator
BED33_RS17935	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BED33_RS17940	COG2723	6-phospho-beta-galactosidase activity
BED33_RS17945	COG1447	Phosphotransferase system cellobiose-specific component IIA
BED33_RS17955	COG1794	racemase activity, acting on amino acids and derivatives
BED33_RS17965	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BED33_RS17970	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
BED33_RS17970	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BED33_RS17980	COG3101	peptidyl-lysine hydroxylation
BED33_RS17985	COG0730	response to heat
BED33_RS17990	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
BED33_RS17995	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BED33_RS18000	COG2890	protein-(glutamine-N5) methyltransferase activity
BED33_RS18005	COG2840	Smr protein MutS2
BED33_RS18010	COG2062	phosphohistidine phosphatase, SixA
BED33_RS18015	COG1250	3-hydroxyacyl-CoA dehydrogenase
BED33_RS18015	COG1024	Enoyl-CoA hydratase
BED33_RS18020	COG0183	Belongs to the thiolase family
BED33_RS18025	COG3691	Protein conserved in bacteria
BED33_RS18040	COG4235	cytochrome complex assembly
BED33_RS18040	COG3088	subunit of a heme lyase
BED33_RS18050	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BED33_RS18055	COG1138	Cytochrome C-type biogenesis protein
BED33_RS18060	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
BED33_RS18065	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BED33_RS18070	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BED33_RS18075	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BED33_RS18090	COG2116	formate transmembrane transporter activity
BED33_RS18100	COG0582	viral genome integration into host DNA
BED33_RS18160	COG2824	Alkylphosphonate utilization operon protein PhnA
BED33_RS18165	COG1695	Transcriptional regulator
BED33_RS18175	COG2723	6-phospho-beta-galactosidase activity
BED33_RS18180	COG1263	PTS System
BED33_RS18180	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BED33_RS18185	COG1609	Transcriptional regulator
BED33_RS18190	COG2353	YceI-like domain
BED33_RS18195	COG3038	cytochrome b561
BED33_RS18200	COG2755	lipolytic protein G-D-S-L family
BED33_RS18200	COG0657	acetylesterase activity
BED33_RS18220	COG1127	ABC transporter
BED33_RS18225	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BED33_RS18245	COG0531	amino acid
BED33_RS18250	COG2951	lytic endotransglycosylase activity
BED33_RS18280	COG1598	PFAM Uncharacterised protein family UPF0150
BED33_RS18285	COG3038	cytochrome b561
BED33_RS18290	COG0436	Aminotransferase
BED33_RS18310	COG3279	Response regulator of the LytR AlgR family
BED33_RS18320	COG0837	glucose binding
BED33_RS18335	COG3961	Belongs to the TPP enzyme family
BED33_RS18340	COG0667	Aldo Keto reductase
BED33_RS18355	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BED33_RS18385	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BED33_RS18410	COG3530	Putative quorum-sensing-regulated virulence factor
BED33_RS18415	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BED33_RS18435	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BED33_RS18440	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BED33_RS18450	COG2205	protein histidine kinase activity
BED33_RS18455	COG0745	RESPONSE REGULATOR receiver
BED33_RS18460	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BED33_RS18480	COG4208	sulfate ABC transporter
BED33_RS18485	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
BED33_RS18490	COG4150	thiosulfate binding
BED33_RS18500	COG1737	Transcriptional regulator
BED33_RS18505	COG2731	YhcH YjgK YiaL family protein
BED33_RS18520	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BED33_RS18530	COG2837	iron assimilation
BED33_RS18540	COG3111	PFAM Bacterial OB fold (BOF) protein
BED33_RS18545	COG0456	acetyltransferase
BED33_RS18550	COG0408	coproporphyrinogen oxidase activity
BED33_RS18555	COG1671	Belongs to the UPF0178 family
BED33_RS18570	COG0494	nUDIX hydrolase
BED33_RS18580	COG3043	anaerobic respiration
BED33_RS18585	COG0243	molybdopterin cofactor binding
BED33_RS18590	COG3062	negative regulation of establishment of protein localization
BED33_RS18600	COG2197	response regulator
BED33_RS18610	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BED33_RS18630	COG1393	Belongs to the ArsC family
BED33_RS18635	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BED33_RS18640	COG1876	peptidase activity
BED33_RS18685	COG0400	carboxylic ester hydrolase activity
BED33_RS18700	COG1444	tRNA N-acetyltransferase activity
BED33_RS18705	COG2707	UPF0756 membrane protein
BED33_RS18710	COG2321	neutral zinc metallopeptidase
BED33_RS18715	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
BED33_RS18720	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
BED33_RS18725	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BED33_RS18730	COG2716	regulation of RNA biosynthetic process
BED33_RS18735	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BED33_RS18740	COG0628	permease
BED33_RS18745	COG4783	chaperone-mediated protein folding
BED33_RS18750	COG1393	Belongs to the ArsC family
BED33_RS18755	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BED33_RS18760	COG2233	PERMEase
BED33_RS18765	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BED33_RS18770	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BED33_RS18775	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BED33_RS18780	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BED33_RS18795	COG0581	inorganic phosphate transmembrane transporter activity
BED33_RS18800	COG0573	inorganic phosphate transmembrane transporter activity
BED33_RS18805	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
BED33_RS18825	COG5001	Diguanylate cyclase
BED33_RS18825	COG3447	MASE1 domain protein
BED33_RS18825	COG5002	protein histidine kinase activity
BED33_RS18830	COG0443	Heat shock 70 kDa protein
BED33_RS18835	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BED33_RS18845	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BED33_RS18850	COG0477	Major facilitator Superfamily
BED33_RS18855	COG2205	protein histidine kinase activity
BED33_RS18860	COG0745	RESPONSE REGULATOR receiver
BED33_RS18865	COG3422	double-strand break repair
BED33_RS18870	COG0826	peptidase U32
BED33_RS18875	COG1597	lipid kinase activity
BED33_RS18880	COG3730	PTS system glucitol sorbitol-specific
BED33_RS18895	COG1028	Short-chain dehydrogenase reductase Sdr
BED33_RS18900	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
BED33_RS18905	COG1349	DNA-binding transcription factor activity
BED33_RS18925	COG0351	phosphomethylpyrimidine kinase
BED33_RS18955	COG3328	transposase activity
BED33_RS19020	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BED33_RS19020	COG0519	Catalyzes the synthesis of GMP from XMP
BED33_RS19025	COG0516	GMP reductase activity
BED33_RS19025	COG0517	IMP dehydrogenase activity
BED33_RS19030	COG1570	exodeoxyribonuclease VII activity
BED33_RS19035	COG1645	bacterial-type flagellum-dependent swarming motility
BED33_RS19050	COG1160	GTP binding
BED33_RS19060	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BED33_RS19065	COG2976	Protein conserved in bacteria
BED33_RS19070	COG0124	histidyl-tRNA synthetase
BED33_RS19075	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
BED33_RS19080	COG1426	Protein conserved in bacteria
BED33_RS19090	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BED33_RS19105	COG4953	penicillin-binding protein 1C
BED33_RS19110	COG2373	Large extracellular alpha-helical protein
BED33_RS19115	COG3468	outer membrane autotransporter barrel domain protein
BED33_RS19130	COG2975	iron-sulfur cluster assembly
BED33_RS19135	COG0633	Ferredoxin
BED33_RS19140	COG0443	Heat shock 70 kDa protein
BED33_RS19145	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
BED33_RS19150	COG0316	Belongs to the HesB IscA family
BED33_RS19155	COG0822	iron-sulfur transferase activity
BED33_RS19165	COG1959	2 iron, 2 sulfur cluster binding
BED33_RS19170	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
BED33_RS19180	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
BED33_RS19185	COG3683	transport system, periplasmic component
BED33_RS19195	COG2814	Major facilitator Superfamily
BED33_RS19200	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BED33_RS19205	COG1017	nitric oxide dioxygenase activity
BED33_RS19205	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
BED33_RS19210	COG2188	Transcriptional regulator
BED33_RS19220	COG3457	Alanine racemase
BED33_RS19225	COG1735	metal-dependent hydrolase with the TIM-barrel fold
BED33_RS19240	COG0347	Belongs to the P(II) protein family
BED33_RS19245	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BED33_RS19245	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
BED33_RS19250	COG2204	response regulator
BED33_RS19255	COG3170	Tfp pilus assembly protein FimV
BED33_RS19260	COG2205	protein histidine kinase activity
BED33_RS19275	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
BED33_RS19290	COG0560	Phosphoserine phosphatase
BED33_RS19300	COG1737	Transcriptional regulator
BED33_RS19305	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
BED33_RS19315	COG0736	holo-[acyl-carrier-protein] synthase activity
BED33_RS19320	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
BED33_RS19325	COG1381	Involved in DNA repair and RecF pathway recombination
BED33_RS19330	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
BED33_RS19335	COG0571	ribonuclease III activity
BED33_RS19345	COG0481	GTPase activity
BED33_RS19355	COG3086	response to oxidative stress
BED33_RS19360	COG3026	antisigma factor binding
BED33_RS19365	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
BED33_RS19375	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
BED33_RS19380	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
BED33_RS19385	COG0513	Belongs to the DEAD box helicase family
BED33_RS19415	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
BED33_RS19420	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BED33_RS19425	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BED33_RS19430	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BED33_RS19435	COG0497	DNA recombination
BED33_RS19440	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BED33_RS19450	COG2867	negative regulation of translational initiation
BED33_RS19455	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BED33_RS19470	COG0659	secondary active sulfate transmembrane transporter activity
BED33_RS19475	COG3394	polysaccharide catabolic process
BED33_RS19480	COG2169	Transcriptional regulator
BED33_RS19480	COG1917	Cupin 2, conserved barrel domain protein
BED33_RS19485	COG1447	Phosphotransferase system cellobiose-specific component IIA
BED33_RS19490	COG2723	6-phospho-beta-galactosidase activity
BED33_RS19495	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BED33_RS19500	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BED33_RS19515	COG0667	Aldo Keto reductase
BED33_RS19530	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BED33_RS19540	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
BED33_RS19545	COG4413	Urea transporter
BED33_RS19550	COG0829	nickel cation binding
BED33_RS19555	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
BED33_RS19560	COG0830	nickel cation binding
BED33_RS19570	COG0804	urea catabolic process
BED33_RS19575	COG0832	Belongs to the urease beta subunit family
BED33_RS19580	COG0831	urea catabolic process
BED33_RS19585	COG1124	(ABC) transporter
BED33_RS19595	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BED33_RS19635	COG1278	Cold shock
BED33_RS19660	COG2207	Transcriptional regulator
BED33_RS19675	COG4575	ribosome binding
BED33_RS19685	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BED33_RS19695	COG1780	Probably involved in ribonucleotide reductase function
BED33_RS19705	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BED33_RS19715	COG4176	ABC-type proline glycine betaine transport system permease component
BED33_RS19720	COG2113	Glycine betaine
BED33_RS19735	COG0328	RNA-DNA hybrid ribonuclease activity
BED33_RS19740	COG2226	methyltransferase
BED33_RS19745	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BED33_RS19750	COG0741	lytic transglycosylase activity
BED33_RS19750	COG1388	LysM domain
BED33_RS19760	COG3021	interspecies interaction between organisms
BED33_RS19765	COG2814	Major facilitator Superfamily
BED33_RS19770	COG0583	DNA-binding transcription factor activity
BED33_RS19775	COG0656	L-ascorbic acid biosynthetic process
BED33_RS19785	COG3328	transposase activity
BED33_RS19820	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
BED33_RS19830	COG2011	ABC-type metal ion transport system permease component
BED33_RS19835	COG1464	Belongs to the NlpA lipoprotein family
BED33_RS19845	COG1720	tRNA m6t6A37 methyltransferase activity
BED33_RS19850	COG0442	prolyl-tRNA aminoacylation
BED33_RS19855	COG3015	lipoprotein NlpE involved in copper resistance
BED33_RS19865	COG4681	YaeQ
BED33_RS19875	COG4568	rho-dependent transcription termination
BED33_RS19890	COG0346	lactoylglutathione lyase activity
BED33_RS19895	COG1982	Orn Lys Arg decarboxylase major
BED33_RS19900	COG0825	malonyl-CoA metabolic process
BED33_RS19910	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BED33_RS19920	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BED33_RS19925	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BED33_RS19930	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BED33_RS19935	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
BED33_RS19945	COG0750	zinc metalloprotease
BED33_RS19950	COG0575	Belongs to the CDS family
BED33_RS19960	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
BED33_RS19965	COG0233	cytoplasmic translational termination
BED33_RS19970	COG0528	UMP kinase activity
BED33_RS19975	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BED33_RS19980	COG0052	Belongs to the universal ribosomal protein uS2 family
BED33_RS19990	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
BED33_RS19995	COG2171	N-acyltransferase activity
BED33_RS20010	COG0564	pseudouridine synthase activity
BED33_RS20015	COG3098	single-species biofilm formation
BED33_RS20025	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BED33_RS20025	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BED33_RS20030	COG1611	Belongs to the LOG family
BED33_RS20035	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BED33_RS20045	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
BED33_RS20050	COG2363	Small membrane protein
BED33_RS20055	COG0583	DNA-binding transcription factor activity
BED33_RS20065	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BED33_RS20070	COG2166	iron-sulfur cluster assembly
BED33_RS20075	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
BED33_RS20080	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
BED33_RS20100	COG0860	N-Acetylmuramoyl-L-alanine amidase
BED33_RS20105	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
BED33_RS20105	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BED33_RS20110	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BED33_RS20115	COG1074	ATP-dependent DNA helicase activity
BED33_RS20120	COG1025	Belongs to the peptidase M16 family
BED33_RS20125	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
BED33_RS20130	COG4967	type IV pilus modification protein PilV
BED33_RS20145	COG2165	general secretion pathway protein
BED33_RS20150	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
BED33_RS20155	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BED33_RS20165	COG1051	belongs to the nudix hydrolase family
BED33_RS20175	COG3066	DNA modification
BED33_RS20180	COG0861	Integral membrane protein TerC family
BED33_RS20185	COG0667	Aldo Keto reductase
BED33_RS20195	COG0318	PFAM AMP-dependent synthetase and ligase
BED33_RS20195	COG0204	Acyl-transferase
BED33_RS20205	COG1609	Transcriptional regulator
BED33_RS20215	COG0583	DNA-binding transcription factor activity
BED33_RS20220	COG2814	Major facilitator Superfamily
BED33_RS20290	COG2165	general secretion pathway protein
BED33_RS20300	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BED33_RS20320	COG0288	reversible hydration of carbon dioxide
BED33_RS20325	COG1733	regulation of RNA biosynthetic process
BED33_RS20330	COG1028	Short-chain dehydrogenase reductase Sdr
BED33_RS20340	COG0484	heat shock protein binding
BED33_RS20350	COG3706	GGDEF domain
BED33_RS20355	COG4319	ketosteroid isomerase
BED33_RS20370	COG3328	transposase activity
BED33_RS20375	COG2944	sequence-specific DNA binding
BED33_RS20475	COG0582	viral genome integration into host DNA
BED33_RS20485	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BED33_RS20490	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
BED33_RS20495	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BED33_RS20500	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BED33_RS20505	COG4974	Belongs to the 'phage' integrase family
BED33_RS20510	COG0716	FMN binding
BED33_RS20515	COG4452	Inner membrane protein CreD
BED33_RS20520	COG2205	protein histidine kinase activity
BED33_RS20525	COG0745	RESPONSE REGULATOR receiver
BED33_RS20540	COG0354	folic acid binding
BED33_RS20550	COG1272	protein, Hemolysin III
BED33_RS20560	COG1028	Short-chain dehydrogenase reductase Sdr
BED33_RS20570	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BED33_RS20570	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BED33_RS20575	COG0509	glycine decarboxylation via glycine cleavage system
BED33_RS20580	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BED33_RS20585	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BED33_RS20590	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BED33_RS20595	COG0006	proline dipeptidase activity
BED33_RS20600	COG3079	Belongs to the UPF0149 family
BED33_RS20605	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
BED33_RS20615	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BED33_RS20620	COG0148	phosphopyruvate hydratase activity
BED33_RS20625	COG0504	CTP synthase activity
BED33_RS20630	COG3956	TIGRFAM MazG family protein
BED33_RS20635	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BED33_RS20640	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BED33_RS20645	COG3850	Histidine kinase
BED33_RS20645	COG2205	protein histidine kinase activity
BED33_RS20645	COG4999	Histidine kinase
BED33_RS20645	COG3437	response regulator, receiver
BED33_RS20650	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BED33_RS20655	COG0232	Belongs to the dGTPase family. Type 2 subfamily
BED33_RS20660	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BED33_RS20670	COG2860	membrane
BED33_RS20675	COG0316	Belongs to the HesB IscA family
BED33_RS20685	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BED33_RS20690	COG2223	nitrite transmembrane transporter activity
BED33_RS20695	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BED33_RS20700	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BED33_RS20705	COG1120	ATPase activity
BED33_RS20710	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BED33_RS20715	COG1643	Atp-dependent helicase
BED33_RS20720	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
BED33_RS20725	COG1489	DNA binding
BED33_RS20745	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BED33_RS20750	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
BED33_RS20755	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
BED33_RS20760	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
BED33_RS20765	COG0726	polysaccharide deacetylase
BED33_RS20770	COG0842	Transport permease protein
BED33_RS20775	COG1131	(ABC) transporter
BED33_RS20780	COG0288	reversible hydration of carbon dioxide
BED33_RS20790	COG2132	Multicopper oxidase
BED33_RS20800	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
BED33_RS20805	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
BED33_RS20820	COG3112	Uncharacterised protein family (UPF0231)
BED33_RS20835	COG4977	sequence-specific DNA binding
BED33_RS20845	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BED33_RS20850	COG0508	dehydrogenase complex catalyzes the overall conversion of
BED33_RS20855	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
BED33_RS20860	COG2186	Transcriptional regulator
BED33_RS20865	COG1113	amino acid transport
BED33_RS20870	COG3725	Membrane protein required for beta-lactamase induction
BED33_RS20885	COG4969	Belongs to the N-Me-Phe pilin family
BED33_RS20890	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BED33_RS20895	COG1459	type II secretion system
BED33_RS20900	COG0516	GMP reductase activity
BED33_RS20915	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
BED33_RS20920	COG0494	nUDIX hydrolase
BED33_RS20925	COG0653	protein targeting
BED33_RS20945	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
BED33_RS20950	COG0849	cell division
BED33_RS20955	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
BED33_RS20965	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BED33_RS20970	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BED33_RS20975	COG0772	Belongs to the SEDS family
BED33_RS20985	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BED33_RS20990	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BED33_RS20995	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BED33_RS21000	COG0768	penicillin binding
BED33_RS21005	COG3116	cell division
BED33_RS21010	COG0275	rRNA processing
BED33_RS21015	COG2001	Belongs to the MraZ family
BED33_RS21035	COG0028	Belongs to the TPP enzyme family
BED33_RS21040	COG1022	Amp-dependent synthetase and ligase
BED33_RS21050	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BED33_RS21055	COG0473	3-isopropylmalate dehydrogenase activity
BED33_RS21060	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BED33_RS21070	COG3033	Beta-eliminating lyase
BED33_RS21080	COG2814	Major facilitator Superfamily
BED33_RS21085	COG1882	Formate acetyltransferase
BED33_RS21095	COG4533	DNA binding
BED33_RS21110	COG4143	(ABC) transporter
BED33_RS21115	COG1178	ABC-type Fe3 transport system permease component
BED33_RS21125	COG0586	Pfam SNARE associated Golgi protein
BED33_RS21130	COG0417	DNA replication proofreading
BED33_RS21135	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BED33_RS21145	COG0564	pseudouridine synthase activity
BED33_RS21150	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
BED33_RS21155	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
BED33_RS21170	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BED33_RS21175	COG2967	ApaG domain
BED33_RS21180	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
BED33_RS21185	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BED33_RS21190	COG3610	response to peptide
BED33_RS21195	COG2966	Psort location CytoplasmicMembrane, score
BED33_RS21200	COG1280	lysine exporter protein (LysE YggA)
BED33_RS21205	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BED33_RS21215	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BED33_RS21220	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
BED33_RS21225	COG1047	Peptidyl-prolyl cis-trans
BED33_RS21230	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BED33_RS21235	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BED33_RS21240	COG0196	riboflavin kinase activity
BED33_RS21250	COG0268	Binds directly to 16S ribosomal RNA
BED33_RS21255	COG0583	DNA-binding transcription factor activity
BED33_RS21260	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
BED33_RS21265	COG0484	heat shock protein binding
BED33_RS21270	COG0443	Heat shock 70 kDa protein
BED33_RS21275	COG1584	GPR1 FUN34 yaaH family protein
BED33_RS21290	COG0521	Mo-molybdopterin cofactor biosynthetic process
BED33_RS21295	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BED33_RS21300	COG3022	response to hydroperoxide
BED33_RS21315	COG0083	homoserine kinase activity
BED33_RS21330	COG0745	RESPONSE REGULATOR receiver
BED33_RS21335	COG3045	CreA protein
BED33_RS21340	COG2207	Transcriptional regulator
BED33_RS21340	COG3708	Transcriptional regulator
BED33_RS21345	COG0406	alpha-ribazole phosphatase activity
BED33_RS21355	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
BED33_RS21360	COG0741	lytic transglycosylase activity
BED33_RS21365	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BED33_RS21375	COG2199	diguanylate cyclase activity
BED33_RS21380	COG2885	chlorophyll binding
BED33_RS21385	COG0488	(ABC) transporter
BED33_RS21400	COG0604	alcohol dehydrogenase
BED33_RS21415	COG0560	Phosphoserine phosphatase
BED33_RS21420	COG3726	membrane protein affecting hemolysin expression
BED33_RS21425	COG0813	purine-nucleoside phosphorylase activity
BED33_RS21430	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
BED33_RS21435	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
BED33_RS21445	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BED33_RS21450	COG0084	hydrolase, TatD family'
BED33_RS21455	COG4667	esterase of the alpha-beta hydrolase superfamily
BED33_RS21465	COG2823	Periplasmic or secreted lipoprotein
BED33_RS21470	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
BED33_RS21475	COG0456	acetyltransferase
BED33_RS21480	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
BED33_RS21485	COG2813	Specifically methylates the guanine in position
BED33_RS21490	COG0667	Aldo Keto reductase
BED33_RS21515	COG4772	TonB-dependent receptor
BED33_RS21550	COG3284	Transcriptional regulator
BED33_RS21585	COG2192	nodulation
BED33_RS21600	COG1461	Dihydroxyacetone kinase
BED33_RS21605	COG2376	Dihydroxyacetone kinase
BED33_RS21615	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BED33_RS21620	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BED33_RS21625	COG2235	arginine
BED33_RS21640	COG0859	PFAM glycosyl transferase family 9
BED33_RS21645	COG1070	Carbohydrate kinase
BED33_RS21650	COG2390	Transcriptional regulator
BED33_RS21655	COG1129	ABC transporter
BED33_RS21660	COG1172	Belongs to the binding-protein-dependent transport system permease family
BED33_RS21665	COG1172	Belongs to the binding-protein-dependent transport system permease family
BED33_RS21670	COG1879	ABC-type sugar transport system periplasmic component
BED33_RS21675	COG1830	Aldolase
BED33_RS21680	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
BED33_RS21695	COG3328	transposase activity
BED33_RS21795	COG4792	protein secretion
BED33_RS21800	COG4791	protein targeting
BED33_RS21805	COG4794	Type iii secretion
BED33_RS21900	COG3328	transposase activity
BED33_RS21910	COG4886	Leucine-rich repeat (LRR) protein
BED33_RS21910	COG4886	Leucine-rich repeat (LRR) protein
BED33_RS21945	COG2801	Transposase and inactivated derivatives
BED33_RS21995	COG3177	Filamentation induced by cAMP protein fic
BED33_RS22040	COG0431	NADPH-dependent FMN reductase
BED33_RS22045	COG0640	Transcriptional regulator
BED33_RS22105	COG5599	Phosphatase
BED33_RS22145	COG3609	addiction module antidote protein, CC2985 family
BED33_RS22255	COG4792	protein secretion
BED33_RS22260	COG4791	protein targeting
BED33_RS22265	COG4794	Type iii secretion
BED33_RS22270	COG4790	Type iii secretion
BED33_RS22460	COG2390	Transcriptional regulator
BED33_RS22760	COG1982	Orn Lys Arg decarboxylase major
BED33_RS22865	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate