locus-tag	class	description
BED34_RS00035	COG0187	DNA topoisomerase II activity
BED34_RS00125	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
BED34_RS00140	COG1609	Transcriptional regulator
BED34_RS00155	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BED34_RS00475	COG3188	usher protein
BED34_RS00490	COG0592	DNA-directed DNA polymerase activity
BED34_RS00495	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BED34_RS00500	COG0187	DNA topoisomerase II activity
BED34_RS00505	COG0561	phosphatase activity
BED34_RS00510	COG2423	ornithine cyclodeaminase activity
BED34_RS00520	COG0823	Involved in the tonB-independent uptake of proteins
BED34_RS00525	COG5645	(Lipo)protein
BED34_RS00555	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BED34_RS00565	COG3074	FtsZ-dependent cytokinesis
BED34_RS00570	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BED34_RS00575	COG1575	Belongs to the MenA family. Type 1 subfamily
BED34_RS00580	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
BED34_RS00585	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
BED34_RS00590	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
BED34_RS00595	COG1609	Transcriptional regulator
BED34_RS00600	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BED34_RS00605	COG0254	rRNA binding
BED34_RS00610	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
BED34_RS00615	COG0626	cystathionine gamma-synthase activity
BED34_RS00620	COG0460	homoserine dehydrogenase
BED34_RS00620	COG0527	aspartate kinase activity
BED34_RS00630	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
BED34_RS00645	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BED34_RS00650	COG0165	Argininosuccinate lyase
BED34_RS00705	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
BED34_RS00705	COG0678	peroxiredoxin activity
BED34_RS00715	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BED34_RS00720	COG1309	transcriptional regulator
BED34_RS00730	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BED34_RS00740	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
BED34_RS00780	COG1879	ABC-type sugar transport system periplasmic component
BED34_RS00785	COG1129	ABC transporter
BED34_RS00790	COG1172	Belongs to the binding-protein-dependent transport system permease family
BED34_RS00795	COG1172	Belongs to the binding-protein-dependent transport system permease family
BED34_RS00800	COG0583	DNA-binding transcription factor activity
BED34_RS00805	COG3085	chromosome segregation
BED34_RS00820	COG3978	acetolactate synthase activity
BED34_RS00825	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BED34_RS00830	COG0129	dihydroxy-acid dehydratase activity
BED34_RS00850	COG0583	DNA-binding transcription factor activity
BED34_RS00855	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
BED34_RS00880	COG3121	Chaperone
BED34_RS00900	COG3121	Chaperone
BED34_RS00910	COG1940	carbohydrate kinase activity
BED34_RS00915	COG1609	Transcriptional regulator
BED34_RS00940	COG3328	transposase activity
BED34_RS00980	COG3851	Histidine kinase
BED34_RS00985	COG2197	response regulator
BED34_RS00990	COG2194	sulfuric ester hydrolase activity
BED34_RS00995	COG1764	response to oxidative stress
BED34_RS01005	COG0747	negative chemotaxis
BED34_RS01010	COG0601	transmembrane transport
BED34_RS01015	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BED34_RS01020	COG0444	Belongs to the ABC transporter superfamily
BED34_RS01025	COG4608	Belongs to the ABC transporter superfamily
BED34_RS01030	COG2194	sulfuric ester hydrolase activity
BED34_RS01050	COG1192	Involved in chromosome partitioning
BED34_RS01055	COG1215	transferase activity, transferring glycosyl groups
BED34_RS01060	COG1215	transferase activity, transferring glycosyl groups
BED34_RS01065	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
BED34_RS01070	COG3118	belongs to the thioredoxin family
BED34_RS01070	COG0457	Tetratricopeptide repeat
BED34_RS01080	COG2199	diguanylate cyclase activity
BED34_RS01080	COG2200	EAL domain
BED34_RS01085	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
BED34_RS01100	COG1301	dicarboxylic acid transport
BED34_RS01105	COG0612	Peptidase, M16
BED34_RS01110	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BED34_RS01115	COG1942	4-Oxalocrotonate Tautomerase
BED34_RS01120	COG2200	EAL domain
BED34_RS01130	COG2134	cdp-diacylglycerol pyrophosphatase
BED34_RS01135	COG1295	ribonuclease BN
BED34_RS01145	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BED34_RS01150	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
BED34_RS01160	COG0742	ribosomal rna small subunit methyltransferase
BED34_RS01175	COG0589	response to stress
BED34_RS01190	COG0306	phosphate transporter
BED34_RS01195	COG2081	HI0933 family
BED34_RS01240	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BED34_RS01260	COG1301	dicarboxylic acid transport
BED34_RS01275	COG3799	methylaspartate ammonia-lyase activity
BED34_RS01280	COG4865	methylaspartate mutase activity
BED34_RS01300	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BED34_RS01300	COG1648	precorrin-2 dehydrogenase activity
BED34_RS01305	COG0583	DNA-binding transcription factor activity
BED34_RS01310	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
BED34_RS01310	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
BED34_RS01320	COG0561	phosphatase activity
BED34_RS01330	COG0583	DNA-binding transcription factor activity
BED34_RS01335	COG2814	Major facilitator Superfamily
BED34_RS01345	COG3718	enzyme involved in inositol metabolism
BED34_RS01355	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BED34_RS01365	COG0673	inositol 2-dehydrogenase activity
BED34_RS01370	COG1082	Xylose isomerase domain protein TIM barrel
BED34_RS01375	COG1247	-acetyltransferase
BED34_RS01380	COG1741	Belongs to the pirin family
BED34_RS01385	COG1609	Transcriptional regulator
BED34_RS01390	COG2610	gluconate transmembrane transporter activity
BED34_RS01395	COG3265	gluconokinase activity
BED34_RS01400	COG2095	MarC family integral membrane protein
BED34_RS01405	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BED34_RS01425	COG3275	phosphorelay sensor kinase activity
BED34_RS01430	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
BED34_RS01435	COG1523	belongs to the glycosyl hydrolase 13 family
BED34_RS01445	COG0297	glycogen (starch) synthase activity
BED34_RS01450	COG0058	SHG alpha-glucan phosphorylase activity
BED34_RS01455	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
BED34_RS01470	COG1349	DNA-binding transcription factor activity
BED34_RS01475	COG0705	Rhomboid family
BED34_RS01490	COG2909	trisaccharide binding
BED34_RS01495	COG0058	SHG alpha-glucan phosphorylase activity
BED34_RS01500	COG1640	4-alpha-glucanotransferase
BED34_RS01505	COG0316	Belongs to the HesB IscA family
BED34_RS01505	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
BED34_RS01515	COG0596	Alpha beta hydrolase
BED34_RS01535	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
BED34_RS01540	COG1918	ferrous iron import across plasma membrane
BED34_RS01545	COG2183	response to ionizing radiation
BED34_RS01570	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BED34_RS01585	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
BED34_RS01595	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
BED34_RS01600	COG1011	Hydrolase
BED34_RS01610	COG0494	nUDIX hydrolase
BED34_RS01615	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
BED34_RS01640	COG4796	Type ii and iii secretion system protein
BED34_RS01645	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BED34_RS01665	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BED34_RS01675	COG0180	Tryptophanyl-tRNA synthetase
BED34_RS01680	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BED34_RS01680	COG1648	precorrin-2 dehydrogenase activity
BED34_RS01695	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BED34_RS01700	COG0402	S-adenosylhomocysteine deaminase activity
BED34_RS01705	COG0738	Major facilitator superfamily
BED34_RS01715	COG1486	melibiose metabolic process
BED34_RS01720	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BED34_RS01725	COG0433	COG0433 Predicted ATPase
BED34_RS01750	COG1765	OsmC-like protein
BED34_RS01755	COG3954	Phosphoribulokinase
BED34_RS01760	COG3089	Belongs to the UPF0270 family
BED34_RS01765	COG0429	hydrolase of the alpha beta-hydrolase fold
BED34_RS01780	COG4521	taurine ABC transporter
BED34_RS01790	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BED34_RS01795	COG2175	clavaminate synthase activity
BED34_RS01805	COG1216	Glycosyl transferase, family 2
BED34_RS01810	COG0488	(ABC) transporter
BED34_RS01815	COG2249	NAD(P)H dehydrogenase (quinone) activity
BED34_RS01825	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
BED34_RS01830	COG1047	Peptidyl-prolyl cis-trans
BED34_RS01835	COG2900	Belongs to the SlyX family
BED34_RS01840	COG0545	Peptidyl-prolyl cis-trans isomerase
BED34_RS01845	COG2964	Protein conserved in bacteria
BED34_RS01850	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
BED34_RS01855	COG2923	Belongs to the DsrF TusC family
BED34_RS01860	COG2168	tRNA wobble position uridine thiolation
BED34_RS01865	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BED34_RS01870	COG0049	tRNA binding
BED34_RS01880	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BED34_RS01895	COG0051	transcription antitermination factor activity, RNA binding
BED34_RS01900	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BED34_RS01905	COG0088	Forms part of the polypeptide exit tunnel
BED34_RS01910	COG0089	rRNA binding
BED34_RS01915	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BED34_RS01920	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BED34_RS01925	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
BED34_RS01930	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BED34_RS01935	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BED34_RS01940	COG0255	Belongs to the universal ribosomal protein uL29 family
BED34_RS01945	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BED34_RS01950	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BED34_RS01955	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BED34_RS01960	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BED34_RS01965	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BED34_RS01975	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BED34_RS01980	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BED34_RS01985	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
BED34_RS01990	COG1841	ribosomal large subunit assembly
BED34_RS01995	COG0200	Binds to the 23S rRNA
BED34_RS02000	COG0201	protein transport
BED34_RS02005	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BED34_RS02010	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BED34_RS02015	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BED34_RS02020	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BED34_RS02025	COG0202	RNA polymerase activity
BED34_RS02030	COG0203	ribosomal protein L17
BED34_RS02040	COG0789	Transcriptional regulator
BED34_RS02045	COG3036	rescue of stalled ribosome
BED34_RS02055	COG1970	mechanosensitive ion channel activity
BED34_RS02065	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BED34_RS02065	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BED34_RS02070	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BED34_RS02075	COG0242	peptide deformylase activity
BED34_RS02080	COG0758	DNA mediated transformation
BED34_RS02090	COG0551	DNA topoisomerase type I activity
BED34_RS02095	COG0009	L-threonylcarbamoyladenylate synthase
BED34_RS02100	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BED34_RS02105	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
BED34_RS02140	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
BED34_RS02145	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
BED34_RS02150	COG2224	Isocitrate lyase
BED34_RS02155	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
BED34_RS02160	COG1414	Transcriptional regulator
BED34_RS02185	COG0527	aspartate kinase activity
BED34_RS02190	COG0166	Belongs to the GPI family
BED34_RS02205	COG3833	ABC-type maltose transport systems, permease component
BED34_RS02215	COG2182	Extracellular solute-binding protein
BED34_RS02225	COG4580	involved in the transport of maltose and maltodextrins
BED34_RS02240	COG3161	chorismate lyase activity
BED34_RS02245	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
BED34_RS02250	COG2937	Belongs to the GPAT DAPAT family
BED34_RS02255	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
BED34_RS02260	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BED34_RS02265	COG3237	CsbD-like
BED34_RS02270	COG0735	belongs to the Fur family
BED34_RS02275	COG2755	lipolytic protein G-D-S-L family
BED34_RS02275	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
BED34_RS02280	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BED34_RS02310	COG1448	Aminotransferase
BED34_RS02315	COG2315	Protein conserved in bacteria
BED34_RS02320	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BED34_RS02330	COG3550	peptidyl-serine autophosphorylation
BED34_RS02345	COG2252	PERMEase
BED34_RS02350	COG0025	NhaP-type Na H and K H
BED34_RS02355	COG0583	DNA-binding transcription factor activity
BED34_RS02360	COG1380	Effector of murein hydrolase LrgA
BED34_RS02370	COG1126	abc transporter atp-binding protein
BED34_RS02375	COG0765	amino acid transport
BED34_RS02380	COG4597	amino acid ABC transporter
BED34_RS02385	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BED34_RS02400	COG1560	Kdo2-lipid A biosynthetic process
BED34_RS02405	COG0471	metal ion transport
BED34_RS02410	COG1278	Cold shock
BED34_RS02415	COG1278	Cold shock
BED34_RS02420	COG3133	Outer membrane lipoprotein
BED34_RS02430	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
BED34_RS02435	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BED34_RS02440	COG2264	protein methyltransferase activity
BED34_RS02445	COG4145	pantothenate transmembrane transporter activity
BED34_RS02450	COG3924	membrane
BED34_RS02455	COG0439	Biotin carboxylase
BED34_RS02460	COG0511	ligase activity, forming carbon-carbon bonds
BED34_RS02465	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BED34_RS02470	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
BED34_RS02480	COG0604	alcohol dehydrogenase
BED34_RS02485	COG2199	diguanylate cyclase activity
BED34_RS02485	COG2200	EAL domain
BED34_RS02490	COG1077	Cell shape determining protein MreB Mrl
BED34_RS02495	COG1792	Involved in formation and maintenance of cell shape
BED34_RS02500	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
BED34_RS02505	COG0424	maF-like protein
BED34_RS02510	COG1530	ribonuclease E activity
BED34_RS02515	COG3164	Protein of unknown function
BED34_RS02520	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BED34_RS02525	COG0312	modulator of DNA gyrase
BED34_RS02580	COG0583	DNA-binding transcription factor activity
BED34_RS02590	COG1566	PFAM secretion protein HlyD family protein
BED34_RS02595	COG1289	transmembrane transporter activity
BED34_RS02610	COG2732	(Barnase) inhibitor
BED34_RS02615	COG3028	Belongs to the UPF0307 family
BED34_RS02620	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
BED34_RS02760	COG5301	cellulose 1,4-beta-cellobiosidase activity
BED34_RS02795	COG0312	modulator of DNA gyrase
BED34_RS02805	COG3783	Cytochrome b(562)
BED34_RS02810	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BED34_RS02840	COG3964	amidohydrolase
BED34_RS02860	COG3711	transcriptional antiterminator
BED34_RS02860	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BED34_RS02865	COG3093	addiction module antidote protein HigA
BED34_RS02890	COG0366	Alpha amylase catalytic
BED34_RS02910	COG2308	Evidence 4 Homologs of previously reported genes of
BED34_RS02920	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
BED34_RS02925	COG0540	Belongs to the ATCase OTCase family
BED34_RS02930	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BED34_RS02935	COG1660	Displays ATPase and GTPase activities
BED34_RS02950	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
BED34_RS02955	COG1137	ATPase activity
BED34_RS02960	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
BED34_RS02965	COG3117	lipopolysaccharide transmembrane transporter activity
BED34_RS02970	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
BED34_RS02975	COG0517	IMP dehydrogenase activity
BED34_RS02975	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
BED34_RS02985	COG1127	ABC transporter
BED34_RS02990	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BED34_RS02995	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BED34_RS03000	COG2854	intermembrane phospholipid transfer
BED34_RS03005	COG3113	response to antibiotic
BED34_RS03010	COG5007	Belongs to the BolA IbaG family
BED34_RS03015	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BED34_RS03020	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BED34_RS03025	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BED34_RS03030	COG3105	Protein conserved in bacteria
BED34_RS03035	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
BED34_RS03040	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BED34_RS03045	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BED34_RS03050	COG0625	glutathione transferase activity
BED34_RS03055	COG2969	positive regulation of protein catabolic process
BED34_RS03070	COG0493	'glutamate synthase
BED34_RS03075	COG0067	glutamate synthase
BED34_RS03075	COG0069	glutamate synthase activity
BED34_RS03075	COG0070	glutamate synthase
BED34_RS03080	COG1242	4 iron, 4 sulfur cluster binding
BED34_RS03085	COG5002	protein histidine kinase activity
BED34_RS03085	COG2198	Histidine kinase
BED34_RS03085	COG0784	Response regulator, receiver
BED34_RS03090	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
BED34_RS03095	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BED34_RS03100	COG2823	Periplasmic or secreted lipoprotein
BED34_RS03105	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
BED34_RS03110	COG0792	nuclease activity
BED34_RS03120	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
BED34_RS03175	COG3121	Chaperone
BED34_RS03180	COG3188	usher protein
BED34_RS03195	COG0667	Aldo Keto reductase
BED34_RS03200	COG1064	alcohol dehydrogenase
BED34_RS03205	COG1741	Belongs to the pirin family
BED34_RS03210	COG0583	DNA-binding transcription factor activity
BED34_RS03215	COG0435	Glutathione S-transferase
BED34_RS03220	COG2259	Doxx family
BED34_RS03230	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
BED34_RS03235	COG4575	ribosome binding
BED34_RS03250	COG0586	Pfam SNARE associated Golgi protein
BED34_RS03265	COG2271	Major facilitator Superfamily
BED34_RS03270	COG1904	glucuronate isomerase
BED34_RS03275	COG0246	Mannitol dehydrogenase
BED34_RS03280	COG2721	sulfolactate sulfo-lyase activity
BED34_RS03290	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
BED34_RS03295	COG0861	Integral membrane protein TerC family
BED34_RS03305	COG0673	inositol 2-dehydrogenase activity
BED34_RS03310	COG1451	nucleotide metabolic process
BED34_RS03330	COG2813	Specifically methylates the guanine in position
BED34_RS03340	COG0446	pyridine nucleotide-disulphide oxidoreductase
BED34_RS03340	COG1902	pentaerythritol trinitrate reductase activity
BED34_RS03350	COG3247	response to pH
BED34_RS03360	COG0076	glutamate decarboxylase activity
BED34_RS03365	COG0531	amino acid
BED34_RS03375	COG1263	PTS System
BED34_RS03375	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BED34_RS03380	COG3328	transposase activity
BED34_RS03385	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BED34_RS03385	COG1263	PTS System
BED34_RS03390	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
BED34_RS03400	COG1472	Belongs to the glycosyl hydrolase 3 family
BED34_RS03410	COG3876	Protein conserved in bacteria
BED34_RS03430	COG0358	DNA primase activity
BED34_RS03435	COG0828	Belongs to the bacterial ribosomal protein bS21 family
BED34_RS03440	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BED34_RS03445	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
BED34_RS03450	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BED34_RS03455	COG1968	undecaprenyl-diphosphatase activity
BED34_RS03460	COG0617	tRNA 3'-terminal CCA addition
BED34_RS03465	COG4991	sh3 domain protein
BED34_RS03470	COG3025	triphosphatase activity
BED34_RS03475	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
BED34_RS03480	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
BED34_RS03480	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
BED34_RS03485	COG0531	amino acid
BED34_RS03495	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BED34_RS03500	COG3384	dioxygenase
BED34_RS03505	COG0754	glutathionylspermidine amidase activity
BED34_RS03510	COG5463	Belongs to the UPF0441 family
BED34_RS03520	COG1538	Outer membrane efflux protein
BED34_RS03525	COG0494	nUDIX hydrolase
BED34_RS03530	COG3151	Protein conserved in bacteria
BED34_RS03535	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
BED34_RS03540	COG3150	esterase
BED34_RS03555	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
BED34_RS03560	COG2249	NAD(P)H dehydrogenase (quinone) activity
BED34_RS03565	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BED34_RS03575	COG2132	Multicopper oxidase
BED34_RS03585	COG0656	L-ascorbic acid biosynthetic process
BED34_RS03590	COG1979	alcohol dehydrogenase
BED34_RS03595	COG2207	Transcriptional regulator
BED34_RS03600	COG0586	Pfam SNARE associated Golgi protein
BED34_RS03605	COG0626	cystathionine gamma-synthase activity
BED34_RS03615	COG0848	biopolymer transport protein
BED34_RS03665	COG4964	Belongs to the GSP D family
BED34_RS03690	COG3145	DNA-N1-methyladenine dioxygenase activity
BED34_RS03695	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BED34_RS03705	COG2135	peptidase activity
BED34_RS03725	COG2963	transposase activity
BED34_RS03745	COG0577	efflux transmembrane transporter activity
BED34_RS03745	COG1136	(ABC) transporter
BED34_RS03760	COG2801	Transposase and inactivated derivatives
BED34_RS03780	COG1120	ATPase activity
BED34_RS03785	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BED34_RS03790	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BED34_RS03795	COG4592	Periplasmic binding protein
BED34_RS03805	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BED34_RS03810	COG0840	transmembrane signaling receptor activity
BED34_RS03825	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BED34_RS03860	COG1677	Flagellar hook-basal body complex protein FliE
BED34_RS03905	COG1815	bacterial-type flagellum-dependent cell motility
BED34_RS03910	COG1558	bacterial-type flagellum-dependent cell motility
BED34_RS03915	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
BED34_RS03930	COG4786	Flagellar basal body rod
BED34_RS03940	COG1706	bacterial-type flagellum-dependent cell motility
BED34_RS03975	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BED34_RS03980	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
BED34_RS03985	COG1516	flagellar protein fliS
BED34_RS04005	COG1191	sigma factor activity
BED34_RS04010	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
BED34_RS04020	COG3133	Outer membrane lipoprotein
BED34_RS04025	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
BED34_RS04030	COG0437	4 iron, 4 sulfur cluster binding
BED34_RS04035	COG5557	Pfam Polysulphide reductase, NrfD
BED34_RS04040	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
BED34_RS04045	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
BED34_RS04050	COG1773	rubredoxin
BED34_RS04060	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
BED34_RS04065	COG0298	carbon dioxide binding
BED34_RS04070	COG0409	Hydrogenase expression formation protein
BED34_RS04075	COG0309	Hydrogenase expression formation protein (HypE)
BED34_RS04080	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
BED34_RS04090	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
BED34_RS04105	COG5001	Diguanylate cyclase
BED34_RS04125	COG0477	Major facilitator Superfamily
BED34_RS04140	COG1283	sodium-dependent phosphate transmembrane transporter activity
BED34_RS04150	COG1609	Transcriptional regulator
BED34_RS04160	COG0477	Major facilitator Superfamily
BED34_RS04170	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BED34_RS04190	COG4607	ABC-type enterochelin transport system periplasmic component
BED34_RS04200	COG4605	iron ion homeostasis
BED34_RS04205	COG4604	ABC transporter, ATP-binding protein
BED34_RS04210	COG0024	Methionine aminopeptidase
BED34_RS04235	COG1289	transmembrane transporter activity
BED34_RS04245	COG1982	Orn Lys Arg decarboxylase major
BED34_RS04250	COG0531	amino acid
BED34_RS04290	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
BED34_RS04305	COG1982	Orn Lys Arg decarboxylase major
BED34_RS04315	COG0741	lytic transglycosylase activity
BED34_RS04320	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
BED34_RS04325	COG1194	a g-specific adenine glycosylase
BED34_RS04330	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BED34_RS04335	COG3171	Protein conserved in bacteria
BED34_RS04350	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BED34_RS04355	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BED34_RS04360	COG1872	DUF167
BED34_RS04365	COG0762	integral membrane protein
BED34_RS04370	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BED34_RS04375	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BED34_RS04380	COG2805	Type II/IV secretion system protein
BED34_RS04390	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BED34_RS04395	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BED34_RS04400	COG1678	Uncharacterized ACR, COG1678
BED34_RS04405	COG0189	ligase activity
BED34_RS04410	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BED34_RS04415	COG2356	endonuclease I
BED34_RS04420	COG3091	SprT-like family
BED34_RS04425	COG0640	Transcriptional regulator
BED34_RS04430	COG3328	transposase activity
BED34_RS04445	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BED34_RS04450	COG1166	arginine decarboxylase activity
BED34_RS04460	COG0501	Belongs to the peptidase M48B family
BED34_RS04465	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
BED34_RS04470	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BED34_RS04475	COG0126	phosphoglycerate kinase activity
BED34_RS04480	COG0191	fructose-bisphosphate aldolase activity
BED34_RS04500	COG1279	arginine transmembrane transporter activity
BED34_RS04515	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
BED34_RS04520	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BED34_RS04555	COG0602	queuosine metabolic process
BED34_RS04575	COG0720	synthase
BED34_RS04580	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BED34_RS04585	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BED34_RS04590	COG0175	sulfate reduction
BED34_RS04605	COG2234	aminopeptidase activity
BED34_RS04610	COG1648	precorrin-2 dehydrogenase activity
BED34_RS04610	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BED34_RS04615	COG0175	sulfate reduction
BED34_RS04620	COG2895	sulfate adenylyltransferase (ATP) activity
BED34_RS04625	COG0529	Catalyzes the synthesis of activated sulfate
BED34_RS04635	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
BED34_RS04645	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
BED34_RS04650	COG0585	pseudouridine synthase activity
BED34_RS04655	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
BED34_RS04660	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BED34_RS04665	COG1388	LysM domain
BED34_RS04665	COG4942	peptidase
BED34_RS04670	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BED34_RS04675	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BED34_RS04700	COG3188	usher protein
BED34_RS04705	COG3121	Chaperone
BED34_RS04715	COG3539	Fimbrial protein
BED34_RS04720	COG3539	Fimbrial protein
BED34_RS04750	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BED34_RS04760	COG1538	Outer membrane efflux protein
BED34_RS04780	COG1028	Short-chain dehydrogenase reductase Sdr
BED34_RS04785	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BED34_RS04790	COG1858	cytochrome C peroxidase
BED34_RS04800	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BED34_RS04805	COG0640	Transcriptional regulator
BED34_RS04860	COG0410	ABC transporter
BED34_RS04865	COG1137	ATPase activity
BED34_RS04870	COG4177	L-phenylalanine transmembrane transporter activity
BED34_RS04885	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
BED34_RS04885	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
BED34_RS04890	COG0243	molybdopterin cofactor binding
BED34_RS04895	COG0437	4 iron, 4 sulfur cluster binding
BED34_RS04900	COG3302	dmso reductase anchor subunit
BED34_RS04905	COG3381	protein complex oligomerization
BED34_RS04925	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BED34_RS04930	COG2137	regulation of response to DNA damage stimulus
BED34_RS04935	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BED34_RS04940	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
BED34_RS04960	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BED34_RS04965	COG1238	metal cluster binding
BED34_RS04970	COG2918	glutathione biosynthetic process
BED34_RS04975	COG1854	S-ribosylhomocysteine lyase activity
BED34_RS04980	COG4536	flavin adenine dinucleotide binding
BED34_RS04995	COG4137	Cytochrome C assembly protein
BED34_RS05000	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BED34_RS05005	COG0228	four-way junction DNA binding
BED34_RS05010	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BED34_RS05015	COG0336	Belongs to the RNA methyltransferase TrmD family
BED34_RS05020	COG0335	large ribosomal subunit rRNA binding
BED34_RS05030	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
BED34_RS05035	COG3279	Response regulator of the LytR AlgR family
BED34_RS05040	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BED34_RS05045	COG0287	Prephenate dehydrogenase
BED34_RS05045	COG1605	Chorismate mutase
BED34_RS05050	COG1605	Chorismate mutase
BED34_RS05050	COG0077	Prephenate dehydratase
BED34_RS05060	COG0542	response to heat
BED34_RS05070	COG0564	pseudouridine synthase activity
BED34_RS05075	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BED34_RS05085	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
BED34_RS05090	COG3328	transposase activity
BED34_RS05125	COG5544	Lipoprotein
BED34_RS05130	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BED34_RS05135	COG0045	succinate-CoA ligase (ADP-forming) activity
BED34_RS05135	COG1042	CoA-binding domain protein
BED34_RS05135	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BED34_RS05140	COG3148	PFAM DTW domain containing protein
BED34_RS05145	COG3118	belongs to the thioredoxin family
BED34_RS05150	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BED34_RS05155	COG2814	Major facilitator Superfamily
BED34_RS05160	COG1566	PFAM secretion protein HlyD family protein
BED34_RS05165	COG1538	Outer membrane efflux protein
BED34_RS05170	COG1846	Transcriptional regulator
BED34_RS05180	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
BED34_RS05185	COG2814	Major facilitator Superfamily
BED34_RS05220	COG0765	amino acid transport
BED34_RS05225	COG0765	amino acid transport
BED34_RS05235	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BED34_RS05250	COG0436	Aminotransferase
BED34_RS05255	COG0582	viral genome integration into host DNA
BED34_RS05310	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BED34_RS05390	COG1484	DNA-dependent DNA replication
BED34_RS05490	COG5410	chromosome segregation
BED34_RS05625	COG0235	Class ii aldolase
BED34_RS05630	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
BED34_RS05635	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
BED34_RS05640	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
BED34_RS05645	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
BED34_RS05665	COG1960	acyl-CoA dehydrogenase activity
BED34_RS05675	COG0121	glutamine amidotransferase
BED34_RS05680	COG3034	peptidoglycan biosynthetic process
BED34_RS05685	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
BED34_RS05690	COG1805	sodium ion transport
BED34_RS05695	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
BED34_RS05700	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
BED34_RS05710	COG2871	sodium ion transport
BED34_RS05715	COG1477	protein flavinylation
BED34_RS05720	COG2991	Protein conserved in bacteria
BED34_RS05730	COG1181	Belongs to the D-alanine--D-alanine ligase family
BED34_RS05735	COG2964	Protein conserved in bacteria
BED34_RS05750	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BED34_RS05755	COG2195	Cleaves the N-terminal amino acid of tripeptides
BED34_RS05760	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
BED34_RS05770	COG1073	alpha beta
BED34_RS05780	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BED34_RS05785	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
BED34_RS05790	COG2188	Transcriptional regulator
BED34_RS05810	COG3459	Glycosyltransferase 36 associated
BED34_RS05825	COG2226	methyltransferase
BED34_RS05850	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BED34_RS05855	COG3123	guanosine phosphorylase activity
BED34_RS05860	COG2974	May be involved in recombination
BED34_RS05865	COG1940	carbohydrate kinase activity
BED34_RS05870	COG0419	ATPase involved in DNA repair
BED34_RS05875	COG0420	3'-5' exonuclease activity
BED34_RS05880	COG0745	RESPONSE REGULATOR receiver
BED34_RS05885	COG5002	protein histidine kinase activity
BED34_RS05905	COG0366	Alpha amylase catalytic
BED34_RS05925	COG0450	alkyl hydroperoxide reductase
BED34_RS05930	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
BED34_RS05935	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
BED34_RS05945	COG0343	queuine tRNA-ribosyltransferase activity
BED34_RS05950	COG1862	Preprotein translocase
BED34_RS05955	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BED34_RS05960	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BED34_RS05975	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BED34_RS05980	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BED34_RS05980	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BED34_RS05985	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
BED34_RS05990	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BED34_RS05995	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
BED34_RS06000	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
BED34_RS06010	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BED34_RS06015	COG0142	geranyltranstransferase activity
BED34_RS06025	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BED34_RS06025	COG0301	tRNA thio-modification
BED34_RS06035	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BED34_RS06040	COG1666	GTP binding
BED34_RS06045	COG2814	Major facilitator Superfamily
BED34_RS06050	COG0109	protoheme IX farnesyltransferase activity
BED34_RS06055	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
BED34_RS06060	COG1845	cytochrome c oxidase, subunit III
BED34_RS06065	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BED34_RS06070	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BED34_RS06080	COG2223	nitrite transmembrane transporter activity
BED34_RS06085	COG3056	Lipoprotein
BED34_RS06090	COG0271	Belongs to the BolA IbaG family
BED34_RS06100	COG0544	peptidyl-prolyl cis-trans isomerase activity
BED34_RS06105	COG0740	serine-type endopeptidase activity
BED34_RS06110	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BED34_RS06115	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BED34_RS06120	COG0776	regulation of translation
BED34_RS06125	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BED34_RS06130	COG1555	photosystem II stabilization
BED34_RS06135	COG0824	Thioesterase
BED34_RS06140	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
BED34_RS06145	COG4533	DNA binding
BED34_RS06150	COG0561	phosphatase activity
BED34_RS06160	COG1522	sequence-specific DNA binding
BED34_RS06165	COG1132	(ABC) transporter
BED34_RS06170	COG1132	(ABC) transporter
BED34_RS06175	COG0347	Belongs to the P(II) protein family
BED34_RS06180	COG0004	ammonium transporteR
BED34_RS06185	COG1946	Acyl-CoA thioesterase
BED34_RS06190	COG3126	Type III secretion system lipoprotein chaperone (YscW)
BED34_RS06195	COG3695	enzyme binding
BED34_RS06225	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BED34_RS06230	COG0803	Belongs to the bacterial solute-binding protein 9 family
BED34_RS06235	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BED34_RS06240	COG0254	rRNA binding
BED34_RS06255	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
BED34_RS06260	COG3457	Alanine racemase
BED34_RS06270	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BED34_RS06275	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BED34_RS06280	COG1309	transcriptional regulator
BED34_RS06285	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
BED34_RS06305	COG2832	Protein of unknown function (DUF454)
BED34_RS06310	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BED34_RS06320	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
BED34_RS06325	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BED34_RS06330	COG0326	Molecular chaperone. Has ATPase activity
BED34_RS06335	COG0563	adenylate kinase activity
BED34_RS06340	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
BED34_RS06350	COG1442	glycosyl transferase family 8
BED34_RS06350	COG1216	Glycosyl transferase, family 2
BED34_RS06355	COG1215	transferase activity, transferring glycosyl groups
BED34_RS06360	COG0438	transferase activity, transferring glycosyl groups
BED34_RS06365	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BED34_RS06370	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BED34_RS06390	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BED34_RS06395	COG4651	solute:proton antiporter activity
BED34_RS06395	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BED34_RS06400	COG2223	nitrite transmembrane transporter activity
BED34_RS06405	COG0737	Belongs to the 5'-nucleotidase family
BED34_RS06415	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BED34_RS06420	COG3735	TraB family
BED34_RS06425	COG2217	Heavy metal translocating P-type atpase
BED34_RS06430	COG0789	Transcriptional regulator
BED34_RS06435	COG1585	Membrane protein implicated in regulation of membrane protease activity
BED34_RS06440	COG0330	HflC and HflK could
BED34_RS06445	COG3118	belongs to the thioredoxin family
BED34_RS06450	COG0300	oxidoreductase activity
BED34_RS06455	COG2755	lipolytic protein G-D-S-L family
BED34_RS06460	COG4181	ATPase activity
BED34_RS06465	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
BED34_RS06470	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
BED34_RS06475	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BED34_RS06480	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BED34_RS06485	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BED34_RS06490	COG0215	cysteine-tRNA ligase activity
BED34_RS06495	COG2501	S4 domain
BED34_RS06500	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BED34_RS06510	COG0582	viral genome integration into host DNA
BED34_RS06560	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BED34_RS06625	COG1484	DNA-dependent DNA replication
BED34_RS06785	COG4386	tail sheath protein
BED34_RS06850	COG0582	viral genome integration into host DNA
BED34_RS06975	COG0305	Participates in initiation and elongation during chromosome replication
BED34_RS07025	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
BED34_RS07065	COG3772	lysozyme
BED34_RS07230	COG0582	viral genome integration into host DNA
BED34_RS07235	COG0582	viral genome integration into host DNA
BED34_RS07240	COG0582	viral genome integration into host DNA
BED34_RS07255	COG3177	Filamentation induced by cAMP protein fic
BED34_RS07340	COG2850	peptidyl-arginine hydroxylation
BED34_RS07355	COG5265	(ABC) transporter
BED34_RS07370	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
BED34_RS07385	COG1278	Cold shock
BED34_RS07400	COG3706	GGDEF domain
BED34_RS07405	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BED34_RS07410	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
BED34_RS07415	COG0321	lipoyl(octanoyl) transferase activity
BED34_RS07420	COG2921	Belongs to the UPF0250 family
BED34_RS07425	COG1686	Belongs to the peptidase S11 family
BED34_RS07430	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
BED34_RS07435	COG0772	Belongs to the SEDS family
BED34_RS07440	COG0768	penicillin binding
BED34_RS07450	COG0799	negative regulation of ribosome biogenesis
BED34_RS07455	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BED34_RS07460	COG1466	dna polymerase III delta subunit
BED34_RS07465	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
BED34_RS07470	COG0495	leucyl-tRNA aminoacylation
BED34_RS07475	COG2888	peptidyl-tyrosine sulfation
BED34_RS07480	COG1126	abc transporter atp-binding protein
BED34_RS07485	COG0765	amino acid transport
BED34_RS07490	COG0765	amino acid transport
BED34_RS07505	COG0815	Transfers the fatty acyl group on membrane lipoproteins
BED34_RS07510	COG4535	Mg2 and Co2 transporter CorC
BED34_RS07515	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
BED34_RS07520	COG1702	phosphate starvation-inducible protein PhoH
BED34_RS07525	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BED34_RS07530	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BED34_RS07565	COG0367	asparagine synthase
BED34_RS07570	COG0647	UMP catabolic process
BED34_RS07575	COG1940	carbohydrate kinase activity
BED34_RS07575	COG1846	Transcriptional regulator
BED34_RS07580	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BED34_RS07585	COG0363	glucosamine-6-phosphate deaminase activity
BED34_RS07595	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BED34_RS07615	COG0735	belongs to the Fur family
BED34_RS07625	COG0840	transmembrane signaling receptor activity
BED34_RS07635	COG0596	Alpha beta hydrolase
BED34_RS07640	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
BED34_RS07645	COG0033	Phosphoglucomutase
BED34_RS07660	COG0745	RESPONSE REGULATOR receiver
BED34_RS07670	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
BED34_RS07675	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
BED34_RS07680	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
BED34_RS07700	COG2994	toxin metabolic process
BED34_RS07710	COG3272	Protein of unknown function (DUF1722)
BED34_RS07720	COG5212	phosphodiesterase
BED34_RS07725	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
BED34_RS07730	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
BED34_RS07735	COG1984	allophanate hydrolase subunit 2
BED34_RS07740	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
BED34_RS07755	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
BED34_RS07765	COG2009	succinate dehydrogenase
BED34_RS07770	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
BED34_RS07775	COG1053	succinate dehydrogenase
BED34_RS07785	COG0567	Dehydrogenase, E1 component
BED34_RS07790	COG0508	dehydrogenase complex catalyzes the overall conversion of
BED34_RS07795	COG0045	succinate-CoA ligase (ADP-forming) activity
BED34_RS07800	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BED34_RS07805	COG0737	Belongs to the 5'-nucleotidase family
BED34_RS07810	COG1271	oxidase subunit
BED34_RS07815	COG1294	oxidase, subunit
BED34_RS07820	COG4890	Cyd operon protein YbgT
BED34_RS07825	COG3790	cyd operon protein YbgE
BED34_RS07830	COG0824	Thioesterase
BED34_RS07835	COG0811	peptide transport
BED34_RS07840	COG0848	biopolymer transport protein
BED34_RS07845	COG3064	Membrane
BED34_RS07845	COG3064	Membrane
BED34_RS07850	COG0823	Involved in the tonB-independent uptake of proteins
BED34_RS07855	COG2885	chlorophyll binding
BED34_RS07860	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
BED34_RS07885	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
BED34_RS07895	COG1230	cation diffusion facilitator family transporter
BED34_RS07900	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BED34_RS07905	COG0588	phosphoglycerate mutase activity
BED34_RS07930	COG2017	converts alpha-aldose to the beta-anomer
BED34_RS07935	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
BED34_RS07940	COG1085	galactose-1-phosphate uridylyltransferase
BED34_RS07945	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BED34_RS07955	COG1119	ATPase activity
BED34_RS07960	COG3585	molybdate ion transport
BED34_RS07960	COG2005	Transcriptional regulator
BED34_RS07970	COG0725	ABC transporter, periplasmic molybdate-binding protein
BED34_RS07975	COG4149	molybdate abc transporter
BED34_RS07985	COG0561	phosphatase activity
BED34_RS07990	COG2706	6-phosphogluconolactonase activity
BED34_RS08000	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
BED34_RS08005	COG0156	8-amino-7-oxononanoate synthase activity
BED34_RS08010	COG2226	methyltransferase
BED34_RS08025	COG0556	nucleotide-excision repair
BED34_RS08030	COG4628	conserved protein (DUF2132)
BED34_RS08035	COG0391	Required for morphogenesis under gluconeogenic growth conditions
BED34_RS08040	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BED34_RS08045	COG0315	cyclic pyranopterin monophosphate synthase activity
BED34_RS08050	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
BED34_RS08055	COG0314	molybdopterin synthase activity
BED34_RS08060	COG0670	Belongs to the BI1 family
BED34_RS08065	COG0842	Transport permease protein
BED34_RS08070	COG0842	Transport permease protein
BED34_RS08075	COG1131	(ABC) transporter
BED34_RS08080	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BED34_RS08085	COG1309	transcriptional regulator
BED34_RS08090	COG0513	Belongs to the DEAD box helicase family
BED34_RS08095	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BED34_RS08105	COG2239	Acts as a magnesium transporter
BED34_RS08110	COG1686	Belongs to the peptidase S11 family
BED34_RS08115	COG0277	FAD linked oxidase domain protein
BED34_RS08135	COG2261	transglycosylase associated protein
BED34_RS08145	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
BED34_RS08160	COG4807	Protein conserved in bacteria
BED34_RS08180	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
BED34_RS08190	COG2897	thiosulfate sulfurtransferase activity
BED34_RS08205	COG1732	Glycine betaine
BED34_RS08215	COG1125	glycine betaine transport
BED34_RS08220	COG1174	glycine betaine transport
BED34_RS08235	COG0583	DNA-binding transcription factor activity
BED34_RS08245	COG0697	spore germination
BED34_RS08265	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BED34_RS08270	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BED34_RS08290	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
BED34_RS08300	COG1126	abc transporter atp-binding protein
BED34_RS08305	COG0765	amino acid transport
BED34_RS08310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BED34_RS08315	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BED34_RS08320	COG0783	Belongs to the Dps family
BED34_RS08325	COG4106	trans-aconitate 2-methyltransferase activity
BED34_RS08340	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
BED34_RS08360	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
BED34_RS08380	COG0488	(ABC) transporter
BED34_RS08390	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BED34_RS08395	COG0303	'Molybdopterin
BED34_RS08410	COG0577	efflux transmembrane transporter activity
BED34_RS08410	COG1136	(ABC) transporter
BED34_RS08440	COG0583	DNA-binding transcription factor activity
BED34_RS08445	COG0477	Major facilitator Superfamily
BED34_RS08450	COG0302	gtp cyclohydrolase
BED34_RS08455	COG2311	Membrane
BED34_RS08480	COG3604	Transcriptional regulator
BED34_RS08490	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
BED34_RS08495	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
BED34_RS08505	COG3260	NADH ubiquinone oxidoreductase 20
BED34_RS08510	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BED34_RS08515	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
BED34_RS08515	COG3261	NADH dehydrogenase
BED34_RS08520	COG0651	ATP synthesis coupled electron transport
BED34_RS08525	COG4237	Hydrogenase 4 membrane
BED34_RS08530	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BED34_RS08535	COG0650	Formate hydrogenlyase subunit 4
BED34_RS08540	COG0651	ATP synthesis coupled electron transport
BED34_RS08545	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
BED34_RS08550	COG0375	protein maturation
BED34_RS08555	COG0298	carbon dioxide binding
BED34_RS08560	COG2949	membrane
BED34_RS08565	COG0281	malic enzyme
BED34_RS08580	COG1346	cytolysis
BED34_RS08585	COG1380	Effector of murein hydrolase LrgA
BED34_RS08590	COG2814	Major facilitator Superfamily
BED34_RS08610	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BED34_RS08610	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BED34_RS08615	COG0489	protein tyrosine kinase activity
BED34_RS08620	COG0572	uridine kinase
BED34_RS08630	COG2982	Protein involved in outer membrane biogenesis
BED34_RS08635	COG3069	C4-dicarboxylate transmembrane transporter activity
BED34_RS08640	COG1253	flavin adenine dinucleotide binding
BED34_RS08680	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BED34_RS08700	COG3328	transposase activity
BED34_RS08725	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BED34_RS08730	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BED34_RS08735	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
BED34_RS08740	COG0140	phosphoribosyl-ATP diphosphatase activity
BED34_RS08740	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BED34_RS08745	COG0107	imidazoleglycerol-phosphate synthase activity
BED34_RS08750	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
BED34_RS08760	COG0131	Imidazoleglycerol-phosphate dehydratase
BED34_RS08760	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
BED34_RS08765	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BED34_RS08775	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
BED34_RS08780	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BED34_RS08785	COG1172	Belongs to the binding-protein-dependent transport system permease family
BED34_RS08790	COG1129	ABC transporter
BED34_RS08795	COG0371	Dehydrogenase
BED34_RS08805	COG0531	amino acid
BED34_RS08810	COG2925	Exonuclease
BED34_RS08815	COG1022	Amp-dependent synthetase and ligase
BED34_RS08815	COG3320	Male sterility
BED34_RS08820	COG1289	transmembrane transporter activity
BED34_RS08825	COG2926	Belongs to the UPF0265 family
BED34_RS08835	COG1172	Belongs to the binding-protein-dependent transport system permease family
BED34_RS08840	COG1129	ABC transporter
BED34_RS08855	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BED34_RS08865	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BED34_RS08885	COG4656	Part of a membrane complex involved in electron transport
BED34_RS08895	COG1012	belongs to the aldehyde dehydrogenase family
BED34_RS08905	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
BED34_RS08990	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
BED34_RS09055	COG1492	cobalamin metabolic process
BED34_RS09075	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
BED34_RS09145	COG0137	argininosuccinate synthase activity
BED34_RS09150	COG0534	Mate efflux family protein
BED34_RS09160	COG0352	thiamine-phosphate diphosphorylase activity
BED34_RS09165	COG0561	phosphatase activity
BED34_RS09170	COG1349	DNA-binding transcription factor activity
BED34_RS09180	COG0784	Response regulator, receiver
BED34_RS09180	COG0835	chemotaxis
BED34_RS09210	COG3842	ATPase activity
BED34_RS09220	COG1840	ABC-type Fe3 transport system, periplasmic component
BED34_RS09225	COG2271	Major facilitator Superfamily
BED34_RS09240	COG4565	transcriptional regulatory protein
BED34_RS09245	COG3290	protein histidine kinase activity
BED34_RS09255	COG3290	protein histidine kinase activity
BED34_RS09260	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
BED34_RS09265	COG3052	prosthetic group binding
BED34_RS09270	COG2301	Belongs to the HpcH HpaI aldolase family
BED34_RS09275	COG3051	citrate lyase alpha subunit
BED34_RS09280	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
BED34_RS09280	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
BED34_RS09290	COG0471	metal ion transport
BED34_RS09305	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BED34_RS09325	COG2814	Major facilitator Superfamily
BED34_RS09330	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
BED34_RS09330	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BED34_RS09335	COG3122	Protein conserved in bacteria
BED34_RS09355	COG3121	Chaperone
BED34_RS09395	COG3228	Belongs to the MtfA family
BED34_RS09405	COG1070	Carbohydrate kinase
BED34_RS09430	COG3121	Chaperone
BED34_RS09440	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
BED34_RS09470	COG3321	synthase
BED34_RS09470	COG0604	alcohol dehydrogenase
BED34_RS09470	COG1028	Short-chain dehydrogenase reductase Sdr
BED34_RS09475	COG3328	transposase activity
BED34_RS09480	COG3250	beta-galactosidase activity
BED34_RS09485	COG1609	Transcriptional regulator
BED34_RS09500	COG0840	transmembrane signaling receptor activity
BED34_RS09515	COG1285	pathogenesis
BED34_RS09525	COG2130	NADP-dependent
BED34_RS09530	COG0589	response to stress
BED34_RS09550	COG1360	Flagellar Motor Protein
BED34_RS09555	COG2198	Histidine kinase
BED34_RS09555	COG0643	Histidine kinase
BED34_RS09560	COG0835	chemotaxis
BED34_RS09565	COG0840	transmembrane signaling receptor activity
BED34_RS09570	COG0840	transmembrane signaling receptor activity
BED34_RS09575	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
BED34_RS09585	COG0745	RESPONSE REGULATOR receiver
BED34_RS09590	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
BED34_RS09595	COG1404	Belongs to the peptidase S8 family
BED34_RS09595	COG4935	Belongs to the peptidase S8 family
BED34_RS09600	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BED34_RS09605	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BED34_RS09620	COG3418	PFAM FlgN family protein
BED34_RS09625	COG2747	anti-sigma28 factor FlgM
BED34_RS09635	COG1815	bacterial-type flagellum-dependent cell motility
BED34_RS09640	COG1558	bacterial-type flagellum-dependent cell motility
BED34_RS09645	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
BED34_RS09680	COG1256	bacterial-type flagellum assembly
BED34_RS09700	COG1338	Plays a role in the flagellum-specific transport system
BED34_RS09720	COG1580	Controls the rotational direction of flagella during chemotaxis
BED34_RS09740	COG1317	bacterial-type flagellum organization
BED34_RS09755	COG1677	Flagellar hook-basal body complex protein FliE
BED34_RS09760	COG0582	viral genome integration into host DNA
BED34_RS09780	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
BED34_RS09785	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
BED34_RS09825	COG1191	sigma factor activity
BED34_RS09835	COG2515	1-aminocyclopropane-1-carboxylate deaminase
BED34_RS09840	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BED34_RS09845	COG0765	amino acid transport
BED34_RS09850	COG1126	abc transporter atp-binding protein
BED34_RS09865	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
BED34_RS09865	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
BED34_RS09865	COG0506	proline dehydrogenase activity
BED34_RS09885	COG3157	Type VI secretion system effector, Hcp
BED34_RS09890	COG0672	)-iron permease
BED34_RS09895	COG2822	iron ion transport
BED34_RS09905	COG0655	NAD(P)H dehydrogenase (quinone) activity
BED34_RS09915	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
BED34_RS09930	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BED34_RS09935	COG0778	Nitroreductase
BED34_RS09940	COG2267	carboxylic ester hydrolase activity
BED34_RS09945	COG0251	oxidation-reduction process
BED34_RS09950	COG1335	isochorismatase
BED34_RS09955	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BED34_RS09960	COG1309	transcriptional regulator
BED34_RS09965	COG1113	amino acid transport
BED34_RS09975	COG0582	viral genome integration into host DNA
BED34_RS09980	COG2963	transposase activity
BED34_RS09995	COG0322	excinuclease ABC activity
BED34_RS10000	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BED34_RS10080	COG2963	transposase activity
BED34_RS10130	COG3772	lysozyme
BED34_RS10135	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
BED34_RS10140	COG2979	Protein of unknown function (DUF533)
BED34_RS10155	COG0012	GTP binding
BED34_RS10165	COG0193	aminoacyl-tRNA hydrolase activity
BED34_RS10180	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BED34_RS10190	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
BED34_RS10195	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
BED34_RS10200	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BED34_RS10205	COG2890	protein-(glutamine-N5) methyltransferase activity
BED34_RS10220	COG2877	3-deoxy-8-phosphooctulonate synthase activity
BED34_RS10225	COG0659	secondary active sulfate transmembrane transporter activity
BED34_RS10230	COG3706	GGDEF domain
BED34_RS10255	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
BED34_RS10260	COG3381	protein complex oligomerization
BED34_RS10270	COG0477	Major facilitator Superfamily
BED34_RS10285	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BED34_RS10295	COG0673	inositol 2-dehydrogenase activity
BED34_RS10300	COG0728	peptidoglycan biosynthetic process
BED34_RS10305	COG0387	Pfam Sodium calcium exchanger
BED34_RS10315	COG2814	Major facilitator Superfamily
BED34_RS10330	COG3850	Histidine kinase
BED34_RS10335	COG1294	oxidase, subunit
BED34_RS10340	COG1271	oxidase subunit
BED34_RS10345	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BED34_RS10350	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BED34_RS10355	COG3138	arginine N-succinyltransferase
BED34_RS10365	COG3724	N-succinylarginine dihydrolase activity
BED34_RS10370	COG2988	succinylglutamate desuccinylase activity
BED34_RS10400	COG1228	amidohydrolase
BED34_RS10410	COG0402	S-adenosylhomocysteine deaminase activity
BED34_RS10440	COG4942	peptidase
BED34_RS10450	COG2222	sugar isomerase
BED34_RS10455	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
BED34_RS10460	COG3716	PTS system mannose fructose sorbose family IID component
BED34_RS10470	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BED34_RS10480	COG1349	DNA-binding transcription factor activity
BED34_RS10500	COG1187	pseudouridine synthase activity
BED34_RS10505	COG0786	glutamate:sodium symporter activity
BED34_RS10525	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BED34_RS10530	COG2226	methyltransferase
BED34_RS10535	COG3788	relative of glutathione S-transferase, MAPEG superfamily
BED34_RS10540	COG1801	Protein of unknown function DUF72
BED34_RS10545	COG1335	isochorismatase
BED34_RS10550	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BED34_RS10555	COG0494	nUDIX hydrolase
BED34_RS10560	COG0217	transcriptional regulatory protein
BED34_RS10565	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
BED34_RS10570	COG0632	four-way junction helicase activity
BED34_RS10575	COG2255	four-way junction helicase activity
BED34_RS10580	COG3104	oligopeptide transport
BED34_RS10585	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BED34_RS10590	COG1121	(ABC) transporter
BED34_RS10595	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
BED34_RS10600	COG0739	heme binding
BED34_RS10605	COG1560	Kdo2-lipid A biosynthetic process
BED34_RS10620	COG0469	pyruvate kinase activity
BED34_RS10625	COG1737	Transcriptional regulator
BED34_RS10630	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BED34_RS10635	COG0800	Aldolase
BED34_RS10640	COG2076	Multidrug Resistance protein
BED34_RS10645	COG2076	Multidrug Resistance protein
BED34_RS10650	COG0251	oxidation-reduction process
BED34_RS10655	COG1199	ATP-dependent helicase activity
BED34_RS10670	COG0318	PFAM AMP-dependent synthetase and ligase
BED34_RS10675	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
BED34_RS10680	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
BED34_RS10685	COG2894	cell division
BED34_RS10690	COG0850	regulation of cytokinetic process
BED34_RS10700	COG3100	YcgL domain-containing protein
BED34_RS10705	COG2951	lytic endotransglycosylase activity
BED34_RS10710	COG0179	Fumarylacetoacetate (FAA) hydrolase
BED34_RS10715	COG2983	Belongs to the UPF0260 family
BED34_RS10740	COG0668	transmembrane transport
BED34_RS10745	COG0625	glutathione transferase activity
BED34_RS10770	COG2203	Gaf domain
BED34_RS10770	COG5001	Diguanylate cyclase
BED34_RS10770	COG4251	negative regulation of phosphorylation
BED34_RS10770	COG3706	GGDEF domain
BED34_RS10795	COG2814	Major facilitator Superfamily
BED34_RS10805	COG3008	intermembrane lipid transfer
BED34_RS10810	COG2995	paraquat-inducible protein a
BED34_RS10815	COG1956	GAF domain-containing protein
BED34_RS10825	COG0793	Belongs to the peptidase S41A family
BED34_RS10830	COG0501	Belongs to the peptidase M48B family
BED34_RS10845	COG0823	Involved in the tonB-independent uptake of proteins
BED34_RS10855	COG3023	N-Acetylmuramoyl-L-alanine amidase
BED34_RS10865	COG1988	membrane-bound metal-dependent
BED34_RS10875	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
BED34_RS10880	COG1653	transport
BED34_RS10885	COG3842	ATPase activity
BED34_RS10890	COG0395	ABC-type sugar transport system, permease component
BED34_RS10895	COG1175	transmembrane transport
BED34_RS10905	COG1028	Short-chain dehydrogenase reductase Sdr
BED34_RS10910	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
BED34_RS10915	COG1917	Cupin 2, conserved barrel domain protein
BED34_RS10920	COG3328	transposase activity
BED34_RS10925	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BED34_RS10935	COG0583	DNA-binding transcription factor activity
BED34_RS10940	COG0427	acetyl-CoA hydrolase
BED34_RS10945	COG1024	Enoyl-CoA hydratase
BED34_RS10950	COG1703	isobutyryl-CoA mutase activity
BED34_RS10960	COG3001	Fructosamine kinase
BED34_RS10965	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BED34_RS10970	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BED34_RS10975	COG1121	(ABC) transporter
BED34_RS10980	COG0803	Belongs to the bacterial solute-binding protein 9 family
BED34_RS11015	COG1811	Na channel or pump
BED34_RS11020	COG4249	Peptidase C14 caspase catalytic subunit p20
BED34_RS11025	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BED34_RS11030	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BED34_RS11035	COG0291	Belongs to the bacterial ribosomal protein bL35 family
BED34_RS11040	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
BED34_RS11045	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BED34_RS11055	COG0776	regulation of translation
BED34_RS11070	COG4139	cobalamin transport
BED34_RS11075	COG0386	Belongs to the glutathione peroxidase family
BED34_RS11080	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
BED34_RS11085	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BED34_RS11090	COG0463	Glycosyl transferase, family 2
BED34_RS11095	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BED34_RS11095	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BED34_RS11100	COG0726	polysaccharide deacetylase
BED34_RS11105	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
BED34_RS11110	COG2076	Multidrug Resistance protein
BED34_RS11115	COG2076	Multidrug Resistance protein
BED34_RS11120	COG0791	NLP P60 protein
BED34_RS11160	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
BED34_RS11165	COG0574	Belongs to the PEP-utilizing enzyme family
BED34_RS11165	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BED34_RS11175	COG0628	permease
BED34_RS11180	COG0277	FAD linked oxidase domain protein
BED34_RS11180	COG0247	lactate metabolic process
BED34_RS11185	COG2050	protein possibly involved in aromatic compounds catabolism
BED34_RS11190	COG0316	Belongs to the HesB IscA family
BED34_RS11195	COG0719	Fe-S assembly protein
BED34_RS11200	COG0396	ATPase activity
BED34_RS11205	COG0719	Fe-S assembly protein
BED34_RS11215	COG2166	iron-sulfur cluster assembly
BED34_RS11220	COG1376	ErfK ybiS ycfS ynhG family protein
BED34_RS11220	COG1388	LysM domain
BED34_RS11250	COG0307	riboflavin synthase, alpha
BED34_RS11255	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BED34_RS11260	COG2814	Major facilitator Superfamily
BED34_RS11265	COG0583	DNA-binding transcription factor activity
BED34_RS11270	COG1609	Transcriptional regulator
BED34_RS11280	COG0791	NLP P60 protein
BED34_RS11285	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
BED34_RS11290	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BED34_RS11300	COG0346	lactoylglutathione lyase activity
BED34_RS11310	COG1309	transcriptional regulator
BED34_RS11315	COG2194	sulfuric ester hydrolase activity
BED34_RS11320	COG3313	Fe-S protein
BED34_RS11325	COG4989	oxidoreductase activity
BED34_RS11330	COG1289	transmembrane transporter activity
BED34_RS11335	COG1566	PFAM secretion protein HlyD family protein
BED34_RS11345	COG1846	Transcriptional regulator
BED34_RS11350	COG3133	Outer membrane lipoprotein
BED34_RS11355	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
BED34_RS11360	COG3895	Periplasmic Protein
BED34_RS11365	COG0259	pyridoxamine-phosphate oxidase activity
BED34_RS11370	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BED34_RS11380	COG0625	glutathione transferase activity
BED34_RS11405	COG3104	oligopeptide transport
BED34_RS11415	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BED34_RS11415	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BED34_RS11425	COG4172	Belongs to the ABC transporter superfamily
BED34_RS11435	COG4171	peptide transport system, permease
BED34_RS11440	COG4168	peptide transport system, permease
BED34_RS11445	COG4166	transmembrane transport
BED34_RS11460	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
BED34_RS11465	COG1842	Phage shock protein A
BED34_RS11475	COG1983	PspC domain protein
BED34_RS11485	COG3106	COG3106 Predicted ATPase
BED34_RS11490	COG3768	UPF0283 membrane protein
BED34_RS11495	COG5654	RES domain protein
BED34_RS11500	COG5642	Protein of unknown function (DUF2384)
BED34_RS11510	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
BED34_RS11515	COG4948	Mandelate Racemase Muconate Lactonizing
BED34_RS11520	COG2866	Carboxypeptidase
BED34_RS11525	COG4166	transmembrane transport
BED34_RS11530	COG0598	Magnesium transport protein CorA
BED34_RS11535	COG0037	tRNA processing
BED34_RS11540	COG0823	Involved in the tonB-independent uptake of proteins
BED34_RS11555	COG1285	pathogenesis
BED34_RS11560	COG3042	response to heat
BED34_RS11565	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BED34_RS11570	COG2911	Protein conserved in bacteria
BED34_RS11580	COG3784	Protein of unknown function (DUF1318)
BED34_RS11585	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
BED34_RS11590	COG1643	Atp-dependent helicase
BED34_RS11605	COG3591	Belongs to the peptidase S1B family
BED34_RS11615	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
BED34_RS11620	COG2205	protein histidine kinase activity
BED34_RS11625	COG0745	RESPONSE REGULATOR receiver
BED34_RS11635	COG0531	amino acid
BED34_RS11650	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
BED34_RS11655	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
BED34_RS11660	COG0589	response to stress
BED34_RS11665	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BED34_RS11670	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BED34_RS11685	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
BED34_RS11690	COG1028	Short-chain dehydrogenase reductase Sdr
BED34_RS11700	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BED34_RS11705	COG3328	transposase activity
BED34_RS11715	COG1011	Hydrolase
BED34_RS11720	COG0440	acetolactate synthase activity
BED34_RS11725	COG0028	Belongs to the TPP enzyme family
BED34_RS11735	COG3023	N-Acetylmuramoyl-L-alanine amidase
BED34_RS11760	COG0625	glutathione transferase activity
BED34_RS11770	COG4221	oxidoreductase activity
BED34_RS11775	COG0583	DNA-binding transcription factor activity
BED34_RS11780	COG2814	Major facilitator Superfamily
BED34_RS11805	COG0114	fumarate hydratase activity
BED34_RS11815	COG5339	Protein conserved in bacteria
BED34_RS11825	COG1609	Transcriptional regulator
BED34_RS11830	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BED34_RS11830	COG1263	PTS System
BED34_RS11835	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
BED34_RS11840	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
BED34_RS11845	COG0385	Bile acid
BED34_RS11850	COG0673	inositol 2-dehydrogenase activity
BED34_RS11865	COG1129	ABC transporter
BED34_RS11870	COG1879	ABC-type sugar transport system periplasmic component
BED34_RS11880	COG2160	L-arabinose isomerase activity
BED34_RS11890	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BED34_RS11920	COG4657	Part of a membrane complex involved in electron transport
BED34_RS11930	COG4656	Part of a membrane complex involved in electron transport
BED34_RS11940	COG3708	Transcriptional regulator
BED34_RS11940	COG2207	Transcriptional regulator
BED34_RS11945	COG4658	electron transport chain
BED34_RS11950	COG4659	FMN binding
BED34_RS11960	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BED34_RS12035	COG0494	nUDIX hydrolase
BED34_RS12125	COG1484	DNA-dependent DNA replication
BED34_RS12205	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BED34_RS12225	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
BED34_RS12230	COG1966	Carbon starvation protein
BED34_RS12235	COG2879	small protein
BED34_RS12240	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BED34_RS12245	COG1349	DNA-binding transcription factor activity
BED34_RS12265	COG0023	Translation Initiation Factor
BED34_RS12270	COG0284	orotidine-5'-phosphate decarboxylase activity
BED34_RS12280	COG3135	benzoate transporter
BED34_RS12285	COG1396	sequence-specific DNA binding
BED34_RS12295	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
BED34_RS12300	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
BED34_RS12305	COG0671	phosphoesterase, PA-phosphatase related
BED34_RS12340	COG0616	signal peptide processing
BED34_RS12345	COG1028	Short-chain dehydrogenase reductase Sdr
BED34_RS12350	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
BED34_RS12360	COG1187	pseudouridine synthase activity
BED34_RS12365	COG0009	L-threonylcarbamoyladenylate synthase
BED34_RS12370	COG0613	PHP domain protein
BED34_RS12380	COG0512	Glutamine amidotransferase of anthranilate synthase
BED34_RS12390	COG0135	phosphoribosylanthranilate isomerase activity
BED34_RS12390	COG0134	indole-3-glycerol-phosphate synthase activity
BED34_RS12395	COG0133	tryptophan synthase activity
BED34_RS12400	COG0159	tryptophan synthase activity
BED34_RS12410	COG3047	cAMP biosynthetic process
BED34_RS12415	COG0727	PFAM Uncharacterised protein family (UPF0153)
BED34_RS12430	COG2917	probably involved in intracellular septation
BED34_RS12435	COG1607	acyl-coa hydrolase
BED34_RS12440	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
BED34_RS12445	COG2350	Protein conserved in bacteria
BED34_RS12460	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BED34_RS12465	COG3099	Belongs to the UPF0263 family
BED34_RS12475	COG0444	Belongs to the ABC transporter superfamily
BED34_RS12480	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BED34_RS12500	COG2095	MarC family integral membrane protein
BED34_RS12505	COG1454	alcohol dehydrogenase
BED34_RS12505	COG1012	belongs to the aldehyde dehydrogenase family
BED34_RS12520	COG2916	Histone family protein nucleoid-structuring protein H-NS
BED34_RS12530	COG0745	RESPONSE REGULATOR receiver
BED34_RS12535	COG1752	Esterase of the alpha-beta hydrolase superfamily
BED34_RS12545	COG3012	SEC-C Motif Domain Protein
BED34_RS12550	COG0788	formyltetrahydrofolate deformylase activity
BED34_RS12565	COG0583	DNA-binding transcription factor activity
BED34_RS12570	COG0708	Exodeoxyribonuclease III
BED34_RS12575	COG0494	nUDIX hydrolase
BED34_RS12585	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BED34_RS12595	COG0778	Nitroreductase
BED34_RS12605	COG0252	asparaginase activity
BED34_RS12610	COG1335	isochorismatase
BED34_RS12625	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BED34_RS12640	COG3713	MltA-interacting MipA family protein
BED34_RS12645	COG2766	serine protein kinase
BED34_RS12650	COG2718	Belongs to the UPF0229 family
BED34_RS12665	COG0583	DNA-binding transcription factor activity
BED34_RS12675	COG2199	diguanylate cyclase activity
BED34_RS12675	COG2200	EAL domain
BED34_RS12675	COG2202	Pas domain
BED34_RS12685	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BED34_RS12690	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BED34_RS12695	COG2719	SpoVR family
BED34_RS12700	COG2186	Transcriptional regulator
BED34_RS12705	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
BED34_RS12710	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
BED34_RS12730	COG3142	Participates in the control of copper homeostasis
BED34_RS12735	COG3102	Protein conserved in bacteria
BED34_RS12740	COG0018	arginyl-trna synthetase
BED34_RS12750	COG1702	phosphate starvation-inducible protein PhoH
BED34_RS12765	COG3658	cytochrome
BED34_RS12770	COG1215	transferase activity, transferring glycosyl groups
BED34_RS12785	COG0006	proline dipeptidase activity
BED34_RS12790	COG4114	ferric iron reductase
BED34_RS12795	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BED34_RS12820	COG0577	efflux transmembrane transporter activity
BED34_RS12820	COG1136	(ABC) transporter
BED34_RS12830	COG0577	efflux transmembrane transporter activity
BED34_RS12830	COG1136	(ABC) transporter
BED34_RS12845	COG0672	)-iron permease
BED34_RS12860	COG2066	Belongs to the glutaminase family
BED34_RS12865	COG3622	Belongs to the hyi family
BED34_RS12870	COG0235	Class ii aldolase
BED34_RS12875	COG3395	kinase activity
BED34_RS12880	COG1349	DNA-binding transcription factor activity
BED34_RS12885	COG3290	protein histidine kinase activity
BED34_RS12890	COG4565	transcriptional regulatory protein
BED34_RS12895	COG3493	citrate carrier protein
BED34_RS12915	COG2223	nitrite transmembrane transporter activity
BED34_RS12920	COG0561	phosphatase activity
BED34_RS12930	COG3328	transposase activity
BED34_RS12935	COG0500	methyltransferase
BED34_RS12945	COG3328	transposase activity
BED34_RS12990	COG4974	Belongs to the 'phage' integrase family
BED34_RS13000	COG1276	copper resistance
BED34_RS13005	COG2372	response to copper ion
BED34_RS13010	COG1528	Iron-storage protein
BED34_RS13025	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BED34_RS13030	COG1770	oligopeptidase
BED34_RS13040	COG3097	Belongs to the UPF0267 family
BED34_RS13045	COG3141	response to X-ray
BED34_RS13050	COG0513	Belongs to the DEAD box helicase family
BED34_RS13055	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
BED34_RS13060	COG3140	Belongs to the UPF0181 family
BED34_RS13070	COG0494	nUDIX hydrolase
BED34_RS13075	COG1760	l-serine dehydratase
BED34_RS13085	COG1253	flavin adenine dinucleotide binding
BED34_RS13090	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
BED34_RS13090	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BED34_RS13095	COG3715	PTS system
BED34_RS13100	COG3716	PTS system mannose fructose sorbose family IID component
BED34_RS13105	COG4811	Protein of unknown function (DUF986)
BED34_RS13110	COG1971	Probably functions as a manganese efflux pump
BED34_RS13120	COG5001	Diguanylate cyclase
BED34_RS13120	COG3447	MASE1 domain protein
BED34_RS13120	COG5002	protein histidine kinase activity
BED34_RS13130	COG2226	methyltransferase
BED34_RS13135	COG0768	penicillin binding
BED34_RS13140	COG1496	oxidoreductase activity
BED34_RS13190	COG2207	Transcriptional regulator
BED34_RS13210	COG1132	(ABC) transporter
BED34_RS13230	COG2203	Gaf domain
BED34_RS13230	COG5001	Diguanylate cyclase
BED34_RS13230	COG4251	negative regulation of phosphorylation
BED34_RS13230	COG3706	GGDEF domain
BED34_RS13245	COG3755	Protein conserved in bacteria
BED34_RS13270	COG1733	regulation of RNA biosynthetic process
BED34_RS13275	COG0702	epimerase
BED34_RS13280	COG2873	o-acetylhomoserine
BED34_RS13300	COG0840	transmembrane signaling receptor activity
BED34_RS13320	COG2211	Major facilitator Superfamily
BED34_RS13335	COG0538	isocitrate dehydrogenase activity
BED34_RS13365	COG0538	isocitrate dehydrogenase activity
BED34_RS13370	COG1187	pseudouridine synthase activity
BED34_RS13380	COG0482	sulfurtransferase activity
BED34_RS13385	COG2915	High frequency lysogenization protein hflD homolog
BED34_RS13390	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BED34_RS13400	COG0745	RESPONSE REGULATOR receiver
BED34_RS13430	COG4591	ABC-type transport system involved in lipoprotein release permease component
BED34_RS13440	COG4591	ABC-type transport system involved in lipoprotein release permease component
BED34_RS13445	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BED34_RS13450	COG3134	Outer membrane lipoprotein
BED34_RS13455	COG1252	NADH dehydrogenase
BED34_RS13460	COG3150	esterase
BED34_RS13465	COG1472	Belongs to the glycosyl hydrolase 3 family
BED34_RS13475	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
BED34_RS13480	COG5633	Lipoprotein
BED34_RS13485	COG0537	adenosine 5'-monophosphoramidase activity
BED34_RS13490	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BED34_RS13500	COG0641	radical SAM
BED34_RS13520	COG1263	PTS System
BED34_RS13520	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BED34_RS13525	COG0084	hydrolase, TatD family'
BED34_RS13530	COG0470	DNA polymerase III
BED34_RS13535	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BED34_RS13540	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BED34_RS13545	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BED34_RS13550	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BED34_RS13560	COG1028	Short-chain dehydrogenase reductase Sdr
BED34_RS13565	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BED34_RS13570	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BED34_RS13575	COG0416	fatty acid biosynthetic process
BED34_RS13580	COG0333	Belongs to the bacterial ribosomal protein bL32 family
BED34_RS13585	COG1399	metal-binding, possibly nucleic acid-binding protein
BED34_RS13590	COG0424	maF-like protein
BED34_RS13595	COG0564	pseudouridine synthase activity
BED34_RS13600	COG1530	ribonuclease E activity
BED34_RS13605	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
BED34_RS13610	COG0418	dihydroorotase activity
BED34_RS13635	COG0628	permease
BED34_RS13640	COG1054	Belongs to the UPF0176 family
BED34_RS13670	COG1560	Kdo2-lipid A biosynthetic process
BED34_RS13680	COG2259	Doxx family
BED34_RS13690	COG2814	Major facilitator Superfamily
BED34_RS13700	COG2943	transferase activity, transferring hexosyl groups
BED34_RS13705	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
BED34_RS13725	COG3263	regulation of cellular component size
BED34_RS13735	COG3916	Acyl-homoserine-lactone synthase
BED34_RS13740	COG2771	luxR family
BED34_RS13745	COG4235	cytochrome complex assembly
BED34_RS13755	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BED34_RS13765	COG3301	Polysulphide reductase, NrfD
BED34_RS13770	COG0437	4 iron, 4 sulfur cluster binding
BED34_RS13775	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
BED34_RS13790	COG2920	part of a sulfur-relay system
BED34_RS13795	COG1254	Belongs to the acylphosphatase family
BED34_RS13810	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BED34_RS13815	COG3785	DNA binding
BED34_RS13820	COG1832	CoA-binding protein
BED34_RS13830	COG1803	Methylglyoxal synthase
BED34_RS13835	COG0210	DNA helicase
BED34_RS13840	COG3304	Inner membrane component domain
BED34_RS13845	COG1289	transmembrane transporter activity
BED34_RS13850	COG3070	regulator of competence-specific genes
BED34_RS13865	COG3120	sequence-specific DNA binding
BED34_RS13870	COG1067	ATP-dependent peptidase activity
BED34_RS13875	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BED34_RS13885	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BED34_RS13890	COG3009	Protein conserved in bacteria
BED34_RS13895	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BED34_RS13895	COG3008	intermembrane lipid transfer
BED34_RS13900	COG2995	paraquat-inducible protein a
BED34_RS13905	COG0488	(ABC) transporter
BED34_RS13910	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BED34_RS13910	COG0116	Belongs to the methyltransferase superfamily
BED34_RS13915	COG3217	Mosc domain protein beta barrel domain protein
BED34_RS13915	COG0633	Ferredoxin
BED34_RS13925	COG0167	dihydroorotate dehydrogenase activity
BED34_RS13930	COG0308	aminopeptidase N
BED34_RS13935	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
BED34_RS13940	COG0017	Asparaginyl-tRNA synthetase
BED34_RS13950	COG1448	Aminotransferase
BED34_RS13960	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BED34_RS13965	COG3108	Peptidase M15
BED34_RS13970	COG2989	Protein conserved in bacteria
BED34_RS13975	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
BED34_RS13985	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
BED34_RS13990	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BED34_RS13995	COG1434	Gram-negative-bacterium-type cell wall biogenesis
BED34_RS14000	COG3173	Aminoglycoside phosphotransferase
BED34_RS14005	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
BED34_RS14010	COG2835	tetraacyldisaccharide 4'-kinase activity
BED34_RS14015	COG1278	Cold shock
BED34_RS14025	COG5383	Protein conserved in bacteria
BED34_RS14030	COG1663	tetraacyldisaccharide 4'-kinase activity
BED34_RS14040	COG0658	competence protein
BED34_RS14040	COG2333	competence protein COMEC
BED34_RS14045	COG0776	regulation of translation
BED34_RS14050	COG0539	negative regulation of cytoplasmic translation
BED34_RS14055	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BED34_RS14060	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BED34_RS14065	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
BED34_RS14070	COG2323	membrane
BED34_RS14075	COG0252	asparaginase activity
BED34_RS14080	COG1944	ATP diphosphatase activity
BED34_RS14085	COG2116	formate transmembrane transporter activity
BED34_RS14090	COG1882	Formate acetyltransferase
BED34_RS14095	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
BED34_RS14100	COG2814	Major facilitator Superfamily
BED34_RS14105	COG3328	transposase activity
BED34_RS14120	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BED34_RS14125	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BED34_RS14130	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
BED34_RS14135	COG1674	ftsk spoiiie
BED34_RS14135	COG3107	peptidoglycan biosynthetic process
BED34_RS14140	COG1522	sequence-specific DNA binding
BED34_RS14145	COG0492	ferredoxin-NADP+ reductase activity
BED34_RS14155	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
BED34_RS14160	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
BED34_RS14165	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BED34_RS14170	COG0542	response to heat
BED34_RS14175	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
BED34_RS14180	COG1278	Cold shock
BED34_RS14190	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BED34_RS14195	COG2990	Protein conserved in bacteria
BED34_RS14200	COG3593	DNA synthesis involved in DNA repair
BED34_RS14205	COG2431	L-lysine efflux transmembrane transporter activity
BED34_RS14210	COG1151	hydroxylamine reductase activity
BED34_RS14215	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
BED34_RS14220	COG0028	Belongs to the TPP enzyme family
BED34_RS14230	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
BED34_RS14235	COG0702	epimerase
BED34_RS14240	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BED34_RS14250	COG1126	abc transporter atp-binding protein
BED34_RS14255	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BED34_RS14260	COG4215	(ABC) transporter
BED34_RS14265	COG4160	amino acid transport
BED34_RS14270	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BED34_RS14275	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BED34_RS14285	COG1177	transmembrane transport
BED34_RS14290	COG1176	ABC-type spermidine putrescine transport system, permease component I
BED34_RS14295	COG3842	ATPase activity
BED34_RS14300	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
BED34_RS14320	COG2985	domain, Protein
BED34_RS14320	COG0569	domain protein
BED34_RS14330	COG0671	phosphoesterase, PA-phosphatase related
BED34_RS14335	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
BED34_RS14340	COG1349	DNA-binding transcription factor activity
BED34_RS14345	COG0814	amino acid
BED34_RS14350	COG1760	l-serine dehydratase
BED34_RS14360	COG1686	Belongs to the peptidase S11 family
BED34_RS14370	COG0626	cystathionine gamma-synthase activity
BED34_RS14375	COG2011	ABC-type metal ion transport system permease component
BED34_RS14400	COG0625	glutathione transferase activity
BED34_RS14405	COG4771	TonB-dependent receptor
BED34_RS14415	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BED34_RS14420	COG0833	amino acid
BED34_RS14425	COG0583	DNA-binding transcription factor activity
BED34_RS14440	COG2855	membrane
BED34_RS14445	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
BED34_RS14470	COG3710	Transcriptional regulator
BED34_RS14475	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BED34_RS14475	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BED34_RS14475	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
BED34_RS14480	COG1105	Belongs to the carbohydrate kinase PfkB family
BED34_RS14495	COG3005	denitrification pathway
BED34_RS14500	COG0243	molybdopterin cofactor binding
BED34_RS14515	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BED34_RS14520	COG1312	Catalyzes the dehydration of D-mannonate
BED34_RS14530	COG0246	Mannitol dehydrogenase
BED34_RS14535	COG2186	Transcriptional regulator
BED34_RS14545	COG0523	cobalamin synthesis protein
BED34_RS14550	COG0671	phosphoesterase, PA-phosphatase related
BED34_RS14555	COG0791	NLP P60 protein
BED34_RS14565	COG2200	EAL domain
BED34_RS14570	COG4166	transmembrane transport
BED34_RS14575	COG4174	ABC transporter (Permease)
BED34_RS14580	COG4239	(ABC) transporter, permease
BED34_RS14585	COG4172	Belongs to the ABC transporter superfamily
BED34_RS14595	COG2814	Major facilitator Superfamily
BED34_RS14600	COG1187	pseudouridine synthase activity
BED34_RS14605	COG1061	Type III restriction enzyme res subunit
BED34_RS14610	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
BED34_RS14615	COG3081	Nucleoid-associated protein
BED34_RS14620	COG3082	Protein of unknown function (DUF1414)
BED34_RS14645	COG3328	transposase activity
BED34_RS14660	COG2801	Transposase and inactivated derivatives
BED34_RS14680	COG2723	6-phospho-beta-galactosidase activity
BED34_RS14685	COG1263	PTS System
BED34_RS14685	COG2190	(PTS) system
BED34_RS14685	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BED34_RS14690	COG1737	Transcriptional regulator
BED34_RS14745	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BED34_RS14760	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
BED34_RS14775	COG2223	nitrite transmembrane transporter activity
BED34_RS14780	COG2198	Histidine kinase
BED34_RS14780	COG0642	Histidine kinase
BED34_RS14785	COG2197	response regulator
BED34_RS14790	COG0784	Response regulator, receiver
BED34_RS14790	COG2205	protein histidine kinase activity
BED34_RS14800	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BED34_RS14805	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BED34_RS14820	COG4574	serine-type endopeptidase inhibitor activity
BED34_RS14840	COG0814	amino acid
BED34_RS14860	COG1441	menaquinone biosynthetic process
BED34_RS14865	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
BED34_RS14870	COG0596	Alpha beta hydrolase
BED34_RS14875	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
BED34_RS14880	COG1169	isochorismate synthase
BED34_RS14885	COG4575	ribosome binding
BED34_RS14890	COG0129	dihydroxy-acid dehydratase activity
BED34_RS14895	COG4702	Belongs to the UPF0303 family
BED34_RS14905	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BED34_RS14910	COG1609	Transcriptional regulator
BED34_RS14915	COG1028	Short-chain dehydrogenase reductase Sdr
BED34_RS14920	COG3265	gluconokinase activity
BED34_RS14940	COG1007	ATP synthesis coupled electron transport
BED34_RS14945	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BED34_RS14950	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BED34_RS14955	COG0713	ATP synthesis coupled electron transport
BED34_RS14960	COG0839	Belongs to the complex I subunit 6 family
BED34_RS14965	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BED34_RS14970	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
BED34_RS14975	COG1034	ATP synthesis coupled electron transport
BED34_RS14990	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BED34_RS14990	COG0649	NAD binding
BED34_RS14995	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BED34_RS15000	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BED34_RS15005	COG0583	DNA-binding transcription factor activity
BED34_RS15010	COG0436	Aminotransferase
BED34_RS15015	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
BED34_RS15020	COG0490	domain, Protein
BED34_RS15020	COG0471	metal ion transport
BED34_RS15030	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BED34_RS15035	COG3013	Belongs to the UPF0304 family
BED34_RS15040	COG3092	negative regulation of chromosome organization
BED34_RS15050	COG0280	phosphate acetyltransferase
BED34_RS15050	COG0857	belongs to the CobB CobQ family
BED34_RS15055	COG1609	Transcriptional regulator
BED34_RS15060	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BED34_RS15070	COG3037	sugar-specific permease SgaT UlaA
BED34_RS15080	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
BED34_RS15095	COG1090	epimerase
BED34_RS15105	COG4598	ABC transporter
BED34_RS15110	COG4160	amino acid transport
BED34_RS15115	COG4215	(ABC) transporter
BED34_RS15120	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BED34_RS15125	COG0163	prenyltransferase activity
BED34_RS15130	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
BED34_RS15135	COG1286	toxin biosynthetic process
BED34_RS15140	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
BED34_RS15145	COG0285	dihydrofolate synthase activity
BED34_RS15150	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
BED34_RS15155	COG0586	Pfam SNARE associated Golgi protein
BED34_RS15165	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BED34_RS15170	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BED34_RS15185	COG0697	spore germination
BED34_RS15190	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BED34_RS15195	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BED34_RS15220	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
BED34_RS15230	COG1609	Transcriptional regulator
BED34_RS15240	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BED34_RS15245	COG2723	6-phospho-beta-galactosidase activity
BED34_RS15250	COG1447	Phosphotransferase system cellobiose-specific component IIA
BED34_RS15260	COG1794	racemase activity, acting on amino acids and derivatives
BED34_RS15270	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BED34_RS15275	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
BED34_RS15275	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BED34_RS15285	COG3101	peptidyl-lysine hydroxylation
BED34_RS15290	COG0730	response to heat
BED34_RS15295	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
BED34_RS15300	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BED34_RS15305	COG2890	protein-(glutamine-N5) methyltransferase activity
BED34_RS15310	COG2840	Smr protein MutS2
BED34_RS15315	COG2062	phosphohistidine phosphatase, SixA
BED34_RS15320	COG1250	3-hydroxyacyl-CoA dehydrogenase
BED34_RS15320	COG1024	Enoyl-CoA hydratase
BED34_RS15325	COG0183	Belongs to the thiolase family
BED34_RS15330	COG3691	Protein conserved in bacteria
BED34_RS15345	COG3088	subunit of a heme lyase
BED34_RS15345	COG4235	cytochrome complex assembly
BED34_RS15355	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BED34_RS15360	COG1138	Cytochrome C-type biogenesis protein
BED34_RS15365	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
BED34_RS15370	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BED34_RS15375	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BED34_RS15380	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BED34_RS15395	COG2116	formate transmembrane transporter activity
BED34_RS15405	COG0582	viral genome integration into host DNA
BED34_RS15465	COG2824	Alkylphosphonate utilization operon protein PhnA
BED34_RS15470	COG1695	Transcriptional regulator
BED34_RS15480	COG2723	6-phospho-beta-galactosidase activity
BED34_RS15485	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BED34_RS15485	COG1263	PTS System
BED34_RS15490	COG1609	Transcriptional regulator
BED34_RS15495	COG2353	YceI-like domain
BED34_RS15500	COG3038	cytochrome b561
BED34_RS15505	COG2755	lipolytic protein G-D-S-L family
BED34_RS15505	COG0657	acetylesterase activity
BED34_RS15525	COG1127	ABC transporter
BED34_RS15530	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BED34_RS15550	COG0531	amino acid
BED34_RS15555	COG2951	lytic endotransglycosylase activity
BED34_RS15585	COG1598	PFAM Uncharacterised protein family UPF0150
BED34_RS15590	COG3038	cytochrome b561
BED34_RS15595	COG0436	Aminotransferase
BED34_RS15615	COG3279	Response regulator of the LytR AlgR family
BED34_RS15625	COG0837	glucose binding
BED34_RS15640	COG3961	Belongs to the TPP enzyme family
BED34_RS15645	COG0667	Aldo Keto reductase
BED34_RS15655	COG1914	H( )-stimulated, divalent metal cation uptake system
BED34_RS15660	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BED34_RS15690	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BED34_RS15715	COG3530	Putative quorum-sensing-regulated virulence factor
BED34_RS15720	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BED34_RS15740	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BED34_RS15745	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BED34_RS15755	COG2205	protein histidine kinase activity
BED34_RS15760	COG0745	RESPONSE REGULATOR receiver
BED34_RS15765	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BED34_RS15785	COG4208	sulfate ABC transporter
BED34_RS15790	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
BED34_RS15795	COG4150	thiosulfate binding
BED34_RS15805	COG1737	Transcriptional regulator
BED34_RS15810	COG2731	YhcH YjgK YiaL family protein
BED34_RS15825	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BED34_RS15835	COG2837	iron assimilation
BED34_RS15845	COG3111	PFAM Bacterial OB fold (BOF) protein
BED34_RS15850	COG0456	acetyltransferase
BED34_RS15855	COG0408	coproporphyrinogen oxidase activity
BED34_RS15860	COG1671	Belongs to the UPF0178 family
BED34_RS15875	COG0494	nUDIX hydrolase
BED34_RS15885	COG3043	anaerobic respiration
BED34_RS15890	COG0243	molybdopterin cofactor binding
BED34_RS15895	COG3062	negative regulation of establishment of protein localization
BED34_RS15905	COG2197	response regulator
BED34_RS15915	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BED34_RS15935	COG1393	Belongs to the ArsC family
BED34_RS15940	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BED34_RS15945	COG1876	peptidase activity
BED34_RS15990	COG0400	carboxylic ester hydrolase activity
BED34_RS16005	COG1444	tRNA N-acetyltransferase activity
BED34_RS16010	COG2707	UPF0756 membrane protein
BED34_RS16015	COG2321	neutral zinc metallopeptidase
BED34_RS16020	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
BED34_RS16025	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
BED34_RS16030	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BED34_RS16035	COG2716	regulation of RNA biosynthetic process
BED34_RS16040	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BED34_RS16045	COG0628	permease
BED34_RS16050	COG4783	chaperone-mediated protein folding
BED34_RS16055	COG1393	Belongs to the ArsC family
BED34_RS16060	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BED34_RS16065	COG2233	PERMEase
BED34_RS16070	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BED34_RS16075	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BED34_RS16080	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BED34_RS16085	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BED34_RS16100	COG0581	inorganic phosphate transmembrane transporter activity
BED34_RS16105	COG0573	inorganic phosphate transmembrane transporter activity
BED34_RS16110	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
BED34_RS16130	COG3447	MASE1 domain protein
BED34_RS16130	COG5001	Diguanylate cyclase
BED34_RS16130	COG5002	protein histidine kinase activity
BED34_RS16135	COG0443	Heat shock 70 kDa protein
BED34_RS16140	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BED34_RS16150	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BED34_RS16155	COG0477	Major facilitator Superfamily
BED34_RS16160	COG2205	protein histidine kinase activity
BED34_RS16165	COG0745	RESPONSE REGULATOR receiver
BED34_RS16170	COG3422	double-strand break repair
BED34_RS16175	COG0826	peptidase U32
BED34_RS16180	COG1597	lipid kinase activity
BED34_RS16185	COG3730	PTS system glucitol sorbitol-specific
BED34_RS16200	COG1028	Short-chain dehydrogenase reductase Sdr
BED34_RS16205	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
BED34_RS16210	COG1349	DNA-binding transcription factor activity
BED34_RS16230	COG0351	phosphomethylpyrimidine kinase
BED34_RS16260	COG3328	transposase activity
BED34_RS16325	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BED34_RS16325	COG0519	Catalyzes the synthesis of GMP from XMP
BED34_RS16330	COG0517	IMP dehydrogenase activity
BED34_RS16330	COG0516	GMP reductase activity
BED34_RS16335	COG1570	exodeoxyribonuclease VII activity
BED34_RS16340	COG1645	bacterial-type flagellum-dependent swarming motility
BED34_RS16355	COG1160	GTP binding
BED34_RS16365	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BED34_RS16370	COG2976	Protein conserved in bacteria
BED34_RS16375	COG0124	histidyl-tRNA synthetase
BED34_RS16380	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
BED34_RS16385	COG1426	Protein conserved in bacteria
BED34_RS16395	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BED34_RS16410	COG4953	penicillin-binding protein 1C
BED34_RS16415	COG2373	Large extracellular alpha-helical protein
BED34_RS16420	COG3468	outer membrane autotransporter barrel domain protein
BED34_RS16435	COG2975	iron-sulfur cluster assembly
BED34_RS16440	COG0633	Ferredoxin
BED34_RS16445	COG0443	Heat shock 70 kDa protein
BED34_RS16450	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
BED34_RS16455	COG0316	Belongs to the HesB IscA family
BED34_RS16460	COG0822	iron-sulfur transferase activity
BED34_RS16470	COG1959	2 iron, 2 sulfur cluster binding
BED34_RS16475	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
BED34_RS16485	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
BED34_RS16490	COG3683	transport system, periplasmic component
BED34_RS16500	COG2814	Major facilitator Superfamily
BED34_RS16505	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BED34_RS16510	COG1017	nitric oxide dioxygenase activity
BED34_RS16510	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
BED34_RS16515	COG2188	Transcriptional regulator
BED34_RS16525	COG3457	Alanine racemase
BED34_RS16530	COG1735	metal-dependent hydrolase with the TIM-barrel fold
BED34_RS16545	COG0347	Belongs to the P(II) protein family
BED34_RS16550	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
BED34_RS16550	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BED34_RS16555	COG2204	response regulator
BED34_RS16560	COG3170	Tfp pilus assembly protein FimV
BED34_RS16565	COG2205	protein histidine kinase activity
BED34_RS16580	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
BED34_RS16595	COG0560	Phosphoserine phosphatase
BED34_RS16605	COG1737	Transcriptional regulator
BED34_RS16610	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
BED34_RS16620	COG0736	holo-[acyl-carrier-protein] synthase activity
BED34_RS16625	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
BED34_RS16630	COG1381	Involved in DNA repair and RecF pathway recombination
BED34_RS16635	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
BED34_RS16640	COG0571	ribonuclease III activity
BED34_RS16650	COG0481	GTPase activity
BED34_RS16660	COG3086	response to oxidative stress
BED34_RS16665	COG3026	antisigma factor binding
BED34_RS16670	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
BED34_RS16680	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
BED34_RS16685	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
BED34_RS16690	COG0513	Belongs to the DEAD box helicase family
BED34_RS16720	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
BED34_RS16725	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BED34_RS16730	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BED34_RS16735	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BED34_RS16740	COG0497	DNA recombination
BED34_RS16745	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BED34_RS16755	COG2867	negative regulation of translational initiation
BED34_RS16760	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BED34_RS16775	COG0659	secondary active sulfate transmembrane transporter activity
BED34_RS16780	COG3394	polysaccharide catabolic process
BED34_RS16785	COG2169	Transcriptional regulator
BED34_RS16785	COG1917	Cupin 2, conserved barrel domain protein
BED34_RS16790	COG1447	Phosphotransferase system cellobiose-specific component IIA
BED34_RS16795	COG2723	6-phospho-beta-galactosidase activity
BED34_RS16800	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BED34_RS16805	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BED34_RS16820	COG0667	Aldo Keto reductase
BED34_RS16835	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BED34_RS16845	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
BED34_RS16850	COG4413	Urea transporter
BED34_RS16855	COG0829	nickel cation binding
BED34_RS16860	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
BED34_RS16865	COG0830	nickel cation binding
BED34_RS16875	COG0804	urea catabolic process
BED34_RS16880	COG0832	Belongs to the urease beta subunit family
BED34_RS16885	COG0831	urea catabolic process
BED34_RS16890	COG1124	(ABC) transporter
BED34_RS16900	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BED34_RS16940	COG1278	Cold shock
BED34_RS16965	COG2207	Transcriptional regulator
BED34_RS16980	COG4575	ribosome binding
BED34_RS16990	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BED34_RS17000	COG1780	Probably involved in ribonucleotide reductase function
BED34_RS17010	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BED34_RS17020	COG4176	ABC-type proline glycine betaine transport system permease component
BED34_RS17025	COG2113	Glycine betaine
BED34_RS17040	COG0328	RNA-DNA hybrid ribonuclease activity
BED34_RS17045	COG2226	methyltransferase
BED34_RS17050	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BED34_RS17055	COG1388	LysM domain
BED34_RS17055	COG0741	lytic transglycosylase activity
BED34_RS17065	COG3021	interspecies interaction between organisms
BED34_RS17070	COG2814	Major facilitator Superfamily
BED34_RS17075	COG0583	DNA-binding transcription factor activity
BED34_RS17080	COG0656	L-ascorbic acid biosynthetic process
BED34_RS17090	COG3328	transposase activity
BED34_RS17125	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
BED34_RS17135	COG2011	ABC-type metal ion transport system permease component
BED34_RS17140	COG1464	Belongs to the NlpA lipoprotein family
BED34_RS17150	COG1720	tRNA m6t6A37 methyltransferase activity
BED34_RS17155	COG0442	prolyl-tRNA aminoacylation
BED34_RS17160	COG3015	lipoprotein NlpE involved in copper resistance
BED34_RS17170	COG4681	YaeQ
BED34_RS17180	COG4568	rho-dependent transcription termination
BED34_RS17195	COG0346	lactoylglutathione lyase activity
BED34_RS17200	COG1982	Orn Lys Arg decarboxylase major
BED34_RS17205	COG0825	malonyl-CoA metabolic process
BED34_RS17215	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BED34_RS17225	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BED34_RS17230	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BED34_RS17235	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BED34_RS17240	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
BED34_RS17250	COG0750	zinc metalloprotease
BED34_RS17255	COG0575	Belongs to the CDS family
BED34_RS17265	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
BED34_RS17270	COG0233	cytoplasmic translational termination
BED34_RS17275	COG0528	UMP kinase activity
BED34_RS17280	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BED34_RS17285	COG0052	Belongs to the universal ribosomal protein uS2 family
BED34_RS17295	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
BED34_RS17300	COG2171	N-acyltransferase activity
BED34_RS17315	COG0564	pseudouridine synthase activity
BED34_RS17320	COG3098	single-species biofilm formation
BED34_RS17330	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BED34_RS17330	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BED34_RS17335	COG1611	Belongs to the LOG family
BED34_RS17340	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BED34_RS17350	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
BED34_RS17355	COG2363	Small membrane protein
BED34_RS17360	COG0583	DNA-binding transcription factor activity
BED34_RS17370	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BED34_RS17375	COG2166	iron-sulfur cluster assembly
BED34_RS17380	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
BED34_RS17385	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
BED34_RS17405	COG0860	N-Acetylmuramoyl-L-alanine amidase
BED34_RS17410	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BED34_RS17410	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
BED34_RS17415	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BED34_RS17420	COG1074	ATP-dependent DNA helicase activity
BED34_RS17425	COG1025	Belongs to the peptidase M16 family
BED34_RS17430	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
BED34_RS17435	COG4967	type IV pilus modification protein PilV
BED34_RS17450	COG2165	general secretion pathway protein
BED34_RS17455	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
BED34_RS17460	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BED34_RS17470	COG1051	belongs to the nudix hydrolase family
BED34_RS17480	COG3066	DNA modification
BED34_RS17485	COG0861	Integral membrane protein TerC family
BED34_RS17490	COG0667	Aldo Keto reductase
BED34_RS17500	COG0204	Acyl-transferase
BED34_RS17500	COG0318	PFAM AMP-dependent synthetase and ligase
BED34_RS17510	COG1609	Transcriptional regulator
BED34_RS17520	COG0583	DNA-binding transcription factor activity
BED34_RS17595	COG2165	general secretion pathway protein
BED34_RS17605	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BED34_RS17625	COG0288	reversible hydration of carbon dioxide
BED34_RS17630	COG1733	regulation of RNA biosynthetic process
BED34_RS17635	COG1028	Short-chain dehydrogenase reductase Sdr
BED34_RS17645	COG0484	heat shock protein binding
BED34_RS17655	COG3706	GGDEF domain
BED34_RS17660	COG4319	ketosteroid isomerase
BED34_RS17675	COG3328	transposase activity
BED34_RS17680	COG2944	sequence-specific DNA binding
BED34_RS17780	COG0582	viral genome integration into host DNA
BED34_RS17790	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BED34_RS17795	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
BED34_RS17800	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BED34_RS17805	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BED34_RS17810	COG4974	Belongs to the 'phage' integrase family
BED34_RS17815	COG0716	FMN binding
BED34_RS17820	COG4452	Inner membrane protein CreD
BED34_RS17825	COG2205	protein histidine kinase activity
BED34_RS17830	COG0745	RESPONSE REGULATOR receiver
BED34_RS17845	COG0354	folic acid binding
BED34_RS17855	COG1272	protein, Hemolysin III
BED34_RS17865	COG1028	Short-chain dehydrogenase reductase Sdr
BED34_RS17875	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BED34_RS17875	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BED34_RS17880	COG0509	glycine decarboxylation via glycine cleavage system
BED34_RS17885	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BED34_RS17890	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BED34_RS17895	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BED34_RS17900	COG0006	proline dipeptidase activity
BED34_RS17905	COG3079	Belongs to the UPF0149 family
BED34_RS17910	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
BED34_RS17920	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BED34_RS17925	COG0148	phosphopyruvate hydratase activity
BED34_RS17930	COG0504	CTP synthase activity
BED34_RS17935	COG3956	TIGRFAM MazG family protein
BED34_RS17940	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BED34_RS17945	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BED34_RS17950	COG2205	protein histidine kinase activity
BED34_RS17950	COG3437	response regulator, receiver
BED34_RS17950	COG3850	Histidine kinase
BED34_RS17950	COG4999	Histidine kinase
BED34_RS17955	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BED34_RS17960	COG0232	Belongs to the dGTPase family. Type 2 subfamily
BED34_RS17965	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BED34_RS17975	COG2860	membrane
BED34_RS17980	COG0316	Belongs to the HesB IscA family
BED34_RS17990	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BED34_RS17995	COG2223	nitrite transmembrane transporter activity
BED34_RS18000	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BED34_RS18005	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BED34_RS18010	COG1120	ATPase activity
BED34_RS18015	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BED34_RS18020	COG1643	Atp-dependent helicase
BED34_RS18025	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
BED34_RS18030	COG1489	DNA binding
BED34_RS18050	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BED34_RS18055	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
BED34_RS18060	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
BED34_RS18065	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
BED34_RS18070	COG0726	polysaccharide deacetylase
BED34_RS18075	COG0842	Transport permease protein
BED34_RS18080	COG1131	(ABC) transporter
BED34_RS18085	COG0288	reversible hydration of carbon dioxide
BED34_RS18095	COG2132	Multicopper oxidase
BED34_RS18105	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
BED34_RS18110	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
BED34_RS18125	COG3112	Uncharacterised protein family (UPF0231)
BED34_RS18140	COG4977	sequence-specific DNA binding
BED34_RS18150	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BED34_RS18155	COG0508	dehydrogenase complex catalyzes the overall conversion of
BED34_RS18160	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
BED34_RS18165	COG2186	Transcriptional regulator
BED34_RS18170	COG1113	amino acid transport
BED34_RS18175	COG3725	Membrane protein required for beta-lactamase induction
BED34_RS18190	COG4969	Belongs to the N-Me-Phe pilin family
BED34_RS18195	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BED34_RS18200	COG1459	type II secretion system
BED34_RS18205	COG0516	GMP reductase activity
BED34_RS18220	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
BED34_RS18225	COG0494	nUDIX hydrolase
BED34_RS18230	COG0653	protein targeting
BED34_RS18250	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
BED34_RS18255	COG0849	cell division
BED34_RS18260	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
BED34_RS18270	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BED34_RS18275	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BED34_RS18280	COG0772	Belongs to the SEDS family
BED34_RS18290	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BED34_RS18295	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BED34_RS18300	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BED34_RS18305	COG0768	penicillin binding
BED34_RS18310	COG3116	cell division
BED34_RS18315	COG0275	rRNA processing
BED34_RS18320	COG2001	Belongs to the MraZ family
BED34_RS18340	COG0028	Belongs to the TPP enzyme family
BED34_RS18345	COG1022	Amp-dependent synthetase and ligase
BED34_RS18355	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BED34_RS18360	COG0473	3-isopropylmalate dehydrogenase activity
BED34_RS18365	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BED34_RS18375	COG3033	Beta-eliminating lyase
BED34_RS18385	COG2814	Major facilitator Superfamily
BED34_RS18390	COG1882	Formate acetyltransferase
BED34_RS18400	COG4533	DNA binding
BED34_RS18415	COG4143	(ABC) transporter
BED34_RS18420	COG1178	ABC-type Fe3 transport system permease component
BED34_RS18430	COG0586	Pfam SNARE associated Golgi protein
BED34_RS18435	COG0417	DNA replication proofreading
BED34_RS18440	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BED34_RS18450	COG0564	pseudouridine synthase activity
BED34_RS18455	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
BED34_RS18460	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
BED34_RS18475	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BED34_RS18480	COG2967	ApaG domain
BED34_RS18485	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
BED34_RS18490	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BED34_RS18495	COG3610	response to peptide
BED34_RS18500	COG2966	Psort location CytoplasmicMembrane, score
BED34_RS18505	COG1280	lysine exporter protein (LysE YggA)
BED34_RS18510	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BED34_RS18520	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BED34_RS18525	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
BED34_RS18530	COG1047	Peptidyl-prolyl cis-trans
BED34_RS18535	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BED34_RS18540	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BED34_RS18545	COG0196	riboflavin kinase activity
BED34_RS18555	COG0268	Binds directly to 16S ribosomal RNA
BED34_RS18560	COG0583	DNA-binding transcription factor activity
BED34_RS18565	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
BED34_RS18570	COG0484	heat shock protein binding
BED34_RS18575	COG0443	Heat shock 70 kDa protein
BED34_RS18580	COG1584	GPR1 FUN34 yaaH family protein
BED34_RS18595	COG0521	Mo-molybdopterin cofactor biosynthetic process
BED34_RS18600	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BED34_RS18605	COG3022	response to hydroperoxide
BED34_RS18620	COG0083	homoserine kinase activity
BED34_RS18635	COG0745	RESPONSE REGULATOR receiver
BED34_RS18640	COG3045	CreA protein
BED34_RS18645	COG3708	Transcriptional regulator
BED34_RS18645	COG2207	Transcriptional regulator
BED34_RS18650	COG0406	alpha-ribazole phosphatase activity
BED34_RS18660	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
BED34_RS18665	COG0741	lytic transglycosylase activity
BED34_RS18670	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BED34_RS18680	COG2199	diguanylate cyclase activity
BED34_RS18685	COG2885	chlorophyll binding
BED34_RS18690	COG0488	(ABC) transporter
BED34_RS18705	COG0604	alcohol dehydrogenase
BED34_RS18720	COG0560	Phosphoserine phosphatase
BED34_RS18725	COG3726	membrane protein affecting hemolysin expression
BED34_RS18730	COG0813	purine-nucleoside phosphorylase activity
BED34_RS18735	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
BED34_RS18740	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
BED34_RS18750	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BED34_RS18755	COG0084	hydrolase, TatD family'
BED34_RS18760	COG4667	esterase of the alpha-beta hydrolase superfamily
BED34_RS18770	COG2823	Periplasmic or secreted lipoprotein
BED34_RS18775	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
BED34_RS18780	COG0456	acetyltransferase
BED34_RS18785	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
BED34_RS18790	COG2813	Specifically methylates the guanine in position
BED34_RS18795	COG0667	Aldo Keto reductase
BED34_RS18820	COG4772	TonB-dependent receptor
BED34_RS18855	COG3284	Transcriptional regulator
BED34_RS18890	COG2192	nodulation
BED34_RS18905	COG1461	Dihydroxyacetone kinase
BED34_RS18910	COG2376	Dihydroxyacetone kinase
BED34_RS18920	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BED34_RS18925	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BED34_RS18930	COG2235	arginine
BED34_RS18945	COG0859	PFAM glycosyl transferase family 9
BED34_RS18950	COG1070	Carbohydrate kinase
BED34_RS18955	COG2390	Transcriptional regulator
BED34_RS18960	COG1129	ABC transporter
BED34_RS18965	COG1172	Belongs to the binding-protein-dependent transport system permease family
BED34_RS18970	COG1172	Belongs to the binding-protein-dependent transport system permease family
BED34_RS18975	COG1879	ABC-type sugar transport system periplasmic component
BED34_RS18980	COG1830	Aldolase
BED34_RS18985	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
BED34_RS19000	COG3328	transposase activity
BED34_RS19030	COG0795	lipopolysaccharide-transporting ATPase activity
BED34_RS19035	COG0795	lipopolysaccharide-transporting ATPase activity
BED34_RS19040	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BED34_RS19045	COG2927	DNA polymerase III (CHI subunit)
BED34_RS19060	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
BED34_RS19070	COG2731	YhcH YjgK YiaL family protein
BED34_RS19080	COG0601	transmembrane transport
BED34_RS19085	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BED34_RS19090	COG0444	Belongs to the ABC transporter superfamily
BED34_RS19095	COG4608	Belongs to the ABC transporter superfamily
BED34_RS19125	COG2188	Transcriptional regulator
BED34_RS19130	COG3624	Phosphonate C-P lyase system protein PhnG
BED34_RS19135	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
BED34_RS19140	COG3626	phosphonate metabolism
BED34_RS19145	COG3627	carbon phosphorus lyase activity
BED34_RS19150	COG4107	phosphonate C-P lyase system protein PhnK
BED34_RS19155	COG4778	phosphonate C-P lyase system protein PhnL
BED34_RS19160	COG3454	Phosphonate metabolism
BED34_RS19165	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
BED34_RS19170	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
BED34_RS19175	COG0702	epimerase
BED34_RS19190	COG3787	Belongs to the UPF0306 family
BED34_RS19200	COG3842	ATPase activity
BED34_RS19205	COG0395	ABC-type sugar transport system, permease component
BED34_RS19210	COG1175	transmembrane transport
BED34_RS19215	COG1653	transport
BED34_RS19230	COG1982	Orn Lys Arg decarboxylase major
BED34_RS19235	COG0531	amino acid
BED34_RS19245	COG3153	acetyltransferase
BED34_RS19250	COG3154	lipid carrier protein
BED34_RS19255	COG0826	peptidase U32
BED34_RS19260	COG0826	peptidase U32
BED34_RS19265	COG3681	Belongs to the UPF0597 family
BED34_RS19270	COG0814	amino acid
BED34_RS19280	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BED34_RS19290	COG0513	Belongs to the DEAD box helicase family
BED34_RS19300	COG1185	polyribonucleotide nucleotidyltransferase activity
BED34_RS19305	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BED34_RS19310	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BED34_RS19315	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BED34_RS19320	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BED34_RS19325	COG0195	Participates in both transcription termination and antitermination
BED34_RS19330	COG0779	Required for maturation of 30S ribosomal subunits
BED34_RS19345	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BED34_RS19350	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BED34_RS19355	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BED34_RS19365	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
BED34_RS19370	COG1534	Rna-binding protein
BED34_RS19380	COG2027	D-alanyl-D-alanine carboxypeptidase
BED34_RS19385	COG0745	RESPONSE REGULATOR receiver
BED34_RS19390	COG0642	Histidine kinase
BED34_RS19395	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BED34_RS19400	COG0697	spore germination
BED34_RS19405	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BED34_RS19410	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BED34_RS19415	COG0142	geranyltranstransferase activity
BED34_RS19425	COG3423	Transcriptional regulator
BED34_RS19430	COG0039	L-malate dehydrogenase activity
BED34_RS19435	COG1438	arginine binding
BED34_RS19445	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BED34_RS19450	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
BED34_RS19460	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
BED34_RS19465	COG2105	PFAM AIG2 family protein
BED34_RS19480	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BED34_RS19485	COG1253	flavin adenine dinucleotide binding
BED34_RS19495	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
BED34_RS19500	COG1218	3'(2'),5'-bisphosphate nucleotidase
BED34_RS19505	COG0737	Belongs to the 5'-nucleotidase family
BED34_RS19515	COG0545	Peptidyl-prolyl cis-trans isomerase
BED34_RS19520	COG3061	Opacity-associated protein A
BED34_RS19530	COG0359	binds to the 23S rRNA
BED34_RS19535	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BED34_RS19540	COG2965	DNA replication, synthesis of RNA primer
BED34_RS19545	COG0360	Binds together with S18 to 16S ribosomal RNA
BED34_RS19555	COG1073	alpha beta
BED34_RS19560	COG3650	response to hydrogen peroxide
BED34_RS19565	COG1960	acyl-CoA dehydrogenase activity
BED34_RS19575	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BED34_RS19580	COG0557	exoribonuclease II activity
BED34_RS19585	COG1959	2 iron, 2 sulfur cluster binding
BED34_RS19590	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
BED34_RS19595	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
BED34_RS19600	COG0330	HflC and HflK could
BED34_RS19605	COG0330	HflC and HflK could
BED34_RS19610	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BED34_RS19615	COG1923	regulation of RNA biosynthetic process
BED34_RS19620	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BED34_RS19625	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BED34_RS19630	COG0860	N-Acetylmuramoyl-L-alanine amidase
BED34_RS19635	COG0802	atpase or kinase
BED34_RS19640	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
BED34_RS19640	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BED34_RS19645	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BED34_RS19660	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
BED34_RS19665	COG1162	GTPase activity
BED34_RS19670	COG0688	phosphatidylethanolamine metabolic process
BED34_RS19675	COG1511	domain protein
BED34_RS19675	COG3264	Mechanosensitive ion channel
BED34_RS19680	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
BED34_RS19685	COG1053	succinate dehydrogenase
BED34_RS19690	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BED34_RS19695	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
BED34_RS19700	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
BED34_RS19720	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BED34_RS19740	COG0459	protein refolding
BED34_RS19745	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
BED34_RS19760	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
BED34_RS19770	COG4232	protein-disulfide reductase activity
BED34_RS19775	COG1929	Belongs to the glycerate kinase type-1 family
BED34_RS19780	COG1309	transcriptional regulator
BED34_RS19790	COG1882	Formate acetyltransferase
BED34_RS19795	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BED34_RS19800	COG0814	amino acid
BED34_RS19805	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BED34_RS19815	COG3721	Heme iron utilization protein
BED34_RS19835	COG3720	iron ion transport
BED34_RS19840	COG4558	Periplasmic binding protein
BED34_RS19845	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BED34_RS19850	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
BED34_RS19865	COG4774	siderophore transport
BED34_RS19875	COG4115	mRNA cleavage
BED34_RS19880	COG2161	toxin-antitoxin pair type II binding
BED34_RS19890	COG4178	(ABC) transporter
BED34_RS19895	COG4771	TonB-dependent receptor
BED34_RS19900	COG3712	iron ion homeostasis
BED34_RS19915	COG0425	Belongs to the sulfur carrier protein TusA family
BED34_RS19920	COG2391	methyltransferase activity
BED34_RS20080	COG2197	response regulator
BED34_RS20085	COG1301	dicarboxylic acid transport
BED34_RS20090	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BED34_RS20095	COG3162	membrane
BED34_RS20100	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BED34_RS20145	COG0138	bifunctional purine biosynthesis protein purh
BED34_RS20150	COG0151	Belongs to the GarS family
BED34_RS20170	COG1515	deoxyribonuclease V activity
BED34_RS20175	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
BED34_RS20180	COG2816	NAD+ diphosphatase activity
BED34_RS20185	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
BED34_RS20200	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BED34_RS20205	COG2104	thiamine diphosphate biosynthetic process
BED34_RS20210	COG2022	thiamine diphosphate biosynthetic process
BED34_RS20225	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BED34_RS20230	COG0085	RNA polymerase activity
BED34_RS20240	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BED34_RS20245	COG0081	regulation of translation
BED34_RS20250	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BED34_RS20255	COG0250	Participates in transcription elongation, termination and antitermination
BED34_RS20265	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BED34_RS20300	COG1072	(Pantothenic acid kinase))
BED34_RS20305	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
BED34_RS20305	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
BED34_RS20350	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BED34_RS20355	COG1739	Uncharacterized protein family UPF0029
BED34_RS20360	COG0006	proline dipeptidase activity
BED34_RS20365	COG1024	Enoyl-CoA hydratase
BED34_RS20365	COG1250	3-hydroxyacyl-CoA dehydrogenase
BED34_RS20370	COG0183	Belongs to the thiolase family
BED34_RS20380	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
BED34_RS20400	COG0805	protein transport
BED34_RS20405	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BED34_RS20410	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BED34_RS20415	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BED34_RS20425	COG2226	methyltransferase
BED34_RS20435	COG0586	Pfam SNARE associated Golgi protein
BED34_RS20440	COG1966	Carbon starvation protein
BED34_RS20455	COG0412	Dienelactone hydrolase
BED34_RS20460	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BED34_RS20465	COG0583	DNA-binding transcription factor activity
BED34_RS20470	COG0697	spore germination
BED34_RS20475	COG0679	Auxin Efflux Carrier
BED34_RS20480	COG0584	glycerophosphoryl diester phosphodiesterase
BED34_RS20485	COG3842	ATPase activity
BED34_RS20490	COG0395	ABC-type sugar transport system, permease component
BED34_RS20495	COG1175	transmembrane transport
BED34_RS20500	COG1653	transport
BED34_RS20535	COG0410	ABC transporter
BED34_RS20545	COG4177	L-phenylalanine transmembrane transporter activity
BED34_RS20555	COG0683	leucine binding
BED34_RS20580	COG2177	Part of the ABC transporter FtsEX involved in
BED34_RS20585	COG2884	Cell division ATP-binding protein ftsE
BED34_RS20590	COG0552	protein localization to endoplasmic reticulum
BED34_RS20595	COG0742	ribosomal rna small subunit methyltransferase
BED34_RS20600	COG3776	membrane
BED34_RS20615	COG3714	YhhN family
BED34_RS20620	COG2217	Heavy metal translocating P-type atpase
BED34_RS20625	COG0425	Belongs to the sulfur carrier protein TusA family
BED34_RS20630	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
BED34_RS20640	COG0247	lactate metabolic process
BED34_RS20645	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
BED34_RS20650	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
BED34_RS20655	COG2271	Major facilitator Superfamily
BED34_RS20660	COG0584	glycerophosphoryl diester phosphodiesterase
BED34_RS20665	COG0561	phosphatase activity
BED34_RS20670	COG2267	carboxylic ester hydrolase activity
BED34_RS20675	COG1280	lysine exporter protein (LysE YggA)
BED34_RS20680	COG1280	lysine exporter protein (LysE YggA)
BED34_RS20685	COG0514	ATP-dependent DNA helicase (RecQ)
BED34_RS20690	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
BED34_RS20695	COG2050	protein possibly involved in aromatic compounds catabolism
BED34_RS20710	COG5564	TIM-barrel signal transduction protein
BED34_RS20715	COG5441	Belongs to the UPF0261 family
BED34_RS20725	COG0210	DNA helicase
BED34_RS20730	COG1011	Hydrolase
BED34_RS20735	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
BED34_RS20740	COG3159	Protein conserved in bacteria
BED34_RS20745	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BED34_RS20755	COG1965	Belongs to the frataxin family
BED34_RS20765	COG3072	Adenylate cyclase
BED34_RS20770	COG0181	hydroxymethylbilane synthase activity
BED34_RS20775	COG1587	Uroporphyrinogen-III synthase
BED34_RS20780	COG2959	enzyme of heme biosynthesis
BED34_RS20785	COG3071	HemY protein
BED34_RS20830	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
BED34_RS20835	COG2244	polysaccharide biosynthetic process
BED34_RS20840	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BED34_RS20845	COG0456	acetyltransferase
BED34_RS20850	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
BED34_RS20855	COG1088	dTDP-glucose 4,6-dehydratase activity
BED34_RS20860	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
BED34_RS20865	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
BED34_RS20870	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
BED34_RS20875	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BED34_RS20885	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
BED34_RS20890	COG3118	belongs to the thioredoxin family
BED34_RS20900	COG0248	Ppx GppA phosphatase
BED34_RS20915	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BED34_RS20945	COG3177	Filamentation induced by cAMP protein fic
BED34_RS20980	COG0582	viral genome integration into host DNA
BED34_RS20985	COG1609	Transcriptional regulator
BED34_RS20985	COG2207	Transcriptional regulator
BED34_RS20990	COG4214	carbohydrate transport
BED34_RS21000	COG4213	ABC transporter substrate-binding protein
BED34_RS21005	COG2115	Belongs to the xylose isomerase family
BED34_RS21010	COG1070	Carbohydrate kinase
BED34_RS21015	COG3121	Chaperone
BED34_RS21030	COG3274	enterobacterial common antigen metabolic process
BED34_RS21040	COG3276	selenocysteine insertion sequence binding
BED34_RS21045	COG1921	L-seryl-tRNASec selenium transferase activity
BED34_RS21050	COG3058	Necessary for formate dehydrogenase activity
BED34_RS21055	COG2864	formate dehydrogenase
BED34_RS21060	COG0437	4 iron, 4 sulfur cluster binding
BED34_RS21065	COG0243	molybdopterin cofactor binding
BED34_RS21065	COG3383	formate dehydrogenase (NAD+) activity
BED34_RS21070	COG0243	molybdopterin cofactor binding
BED34_RS21070	COG3383	formate dehydrogenase (NAD+) activity
BED34_RS21075	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
BED34_RS21080	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BED34_RS21085	COG0840	transmembrane signaling receptor activity
BED34_RS21090	COG2258	MOSC domain
BED34_RS21110	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BED34_RS21120	COG3722	fumarate hydratase activity
BED34_RS21125	COG0246	Mannitol dehydrogenase
BED34_RS21130	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
BED34_RS21130	COG2213	PTS system mannitol-specific
BED34_RS21140	COG0751	glycine-tRNA ligase activity
BED34_RS21145	COG0752	glycyl-tRNA synthetase alpha subunit
BED34_RS21150	COG2818	Glycosylase
BED34_RS21155	COG0456	acetyltransferase
BED34_RS21185	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BED34_RS21190	COG0366	Alpha amylase catalytic
BED34_RS21195	COG3977	Valine--pyruvate aminotransferase
BED34_RS21200	COG0569	domain protein
BED34_RS21200	COG2985	domain, Protein
BED34_RS21210	COG2814	Major facilitator Superfamily
BED34_RS21230	COG3152	Membrane
BED34_RS21240	COG0149	triose-phosphate isomerase activity
BED34_RS21250	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
BED34_RS21260	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
BED34_RS21265	COG3678	ATP-independent chaperone mediated protein folding
BED34_RS21270	COG0745	RESPONSE REGULATOR receiver
BED34_RS21275	COG2205	protein histidine kinase activity
BED34_RS21280	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BED34_RS21280	COG2169	Transcriptional regulator
BED34_RS21285	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
BED34_RS21290	COG1045	serine acetyltransferase
BED34_RS21295	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BED34_RS21300	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
BED34_RS21305	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
BED34_RS21310	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BED34_RS21315	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
BED34_RS21320	COG4942	peptidase
BED34_RS21325	COG2861	carbohydrate metabolic process
BED34_RS21340	COG1063	alcohol dehydrogenase
BED34_RS21345	COG0156	8-amino-7-oxononanoate synthase activity
BED34_RS21350	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BED34_RS21355	COG0859	PFAM glycosyl transferase family 9
BED34_RS21360	COG0859	PFAM glycosyl transferase family 9
BED34_RS21365	COG1519	Transferase
BED34_RS21375	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BED34_RS21380	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BED34_RS21385	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BED34_RS21390	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BED34_RS21395	COG2003	Belongs to the UPF0758 family
BED34_RS21400	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BED34_RS21405	COG0756	dUTP diphosphatase activity
BED34_RS21410	COG1309	transcriptional regulator
BED34_RS21415	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
BED34_RS21420	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
BED34_RS21425	COG1561	YicC-like family, N-terminal region
BED34_RS21430	COG0582	viral genome integration into host DNA
BED34_RS21450	COG3561	AntA/AntB antirepressor
BED34_RS21530	COG5001	Diguanylate cyclase
BED34_RS21535	COG1024	Enoyl-CoA hydratase
BED34_RS21540	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BED34_RS21555	COG2860	membrane
BED34_RS21570	COG1758	RNA polymerase activity
BED34_RS21575	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BED34_RS21580	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BED34_RS21585	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BED34_RS21590	COG0786	glutamate:sodium symporter activity
BED34_RS21595	COG2233	PERMEase
BED34_RS21600	COG2982	Protein involved in outer membrane biogenesis
BED34_RS21615	COG3423	Transcriptional regulator
BED34_RS21620	COG0456	acetyltransferase
BED34_RS21625	COG1490	D-aminoacyl-tRNA deacylase activity
BED34_RS21630	COG1295	ribonuclease BN
BED34_RS21635	COG1011	Hydrolase
BED34_RS21655	COG3852	Histidine kinase
BED34_RS21665	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BED34_RS21670	COG3078	GTPase activator activity
BED34_RS21675	COG0218	Necessary for normal cell division and for the maintenance of normal septation
BED34_RS21680	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BED34_RS21680	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BED34_RS21685	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BED34_RS21690	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
BED34_RS21695	COG3084	Protein conserved in bacteria
BED34_RS21705	COG1763	Mo-molybdopterin cofactor biosynthetic process
BED34_RS21740	COG2186	Transcriptional regulator
BED34_RS21745	COG0477	Major facilitator Superfamily
BED34_RS21750	COG1609	Transcriptional regulator
BED34_RS21755	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BED34_RS21760	COG1879	ABC-type sugar transport system periplasmic component
BED34_RS21765	COG1172	Belongs to the binding-protein-dependent transport system permease family
BED34_RS21775	COG1869	D-ribose catabolic process
BED34_RS21780	COG3158	transport of potassium into the cell
BED34_RS21785	COG0714	Associated with various cellular activities
BED34_RS21790	COG2425	protein containing a von Willebrand factor type A (vWA) domain
BED34_RS21800	COG2502	aspartate--ammonia ligase
BED34_RS21805	COG1522	sequence-specific DNA binding
BED34_RS21810	COG0716	FMN binding
BED34_RS21815	COG0445	tRNA wobble uridine modification
BED34_RS21820	COG0357	Ribosomal RNA small subunit methyltransferase G
BED34_RS21825	COG3312	ion transport
BED34_RS21830	COG0356	it plays a direct role in the translocation of protons across the membrane
BED34_RS21840	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BED34_RS21845	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BED34_RS21850	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BED34_RS21855	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BED34_RS21860	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BED34_RS21865	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BED34_RS21870	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BED34_RS21880	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BED34_RS21885	COG0573	inorganic phosphate transmembrane transporter activity
BED34_RS21890	COG0581	inorganic phosphate transmembrane transporter activity
BED34_RS21900	COG0704	Plays a role in the regulation of phosphate uptake
BED34_RS21910	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BED34_RS21920	COG0765	amino acid transport
BED34_RS21925	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BED34_RS21930	COG2252	PERMEase
BED34_RS21940	COG4566	intracellular signal transduction
BED34_RS21950	COG0431	NADPH-dependent FMN reductase
BED34_RS21955	COG0840	transmembrane signaling receptor activity
BED34_RS21960	COG2011	ABC-type metal ion transport system permease component
BED34_RS21975	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
BED34_RS21980	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BED34_RS21985	COG0706	membrane insertase activity
BED34_RS21995	COG0594	ribonuclease P activity
BED34_RS22000	COG0230	Belongs to the bacterial ribosomal protein bL34 family
BED34_RS22185	COG0460	homoserine dehydrogenase
BED34_RS22185	COG0527	aspartate kinase activity
BED34_RS22525	COG0129	dihydroxy-acid dehydratase activity
BED34_RS22535	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA