locus-tag	class	description
YE0001	COG0716	FMN binding
YE0002	COG1522	sequence-specific DNA binding
YE0003	COG2502	aspartate--ammonia ligase
YE0005	COG2425	protein containing a von Willebrand factor type A (vWA) domain
YE0006	COG0714	Associated with various cellular activities
YE0007	COG3158	transport of potassium into the cell
YE0008	COG1869	D-ribose catabolic process
YE0010	COG1172	Belongs to the binding-protein-dependent transport system permease family
YE0011	COG1879	ABC-type sugar transport system periplasmic component
YE0012	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
YE0012A	COG1609	Transcriptional regulator
YE0013	COG0477	Major facilitator Superfamily
YE0014	COG2186	Transcriptional regulator
YE0016	COG1763	Mo-molybdopterin cofactor biosynthetic process
YE0018	COG3084	Protein conserved in bacteria
YE0019	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
YE0020	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
YE0021	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
YE0021	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
YE0022	COG0218	Necessary for normal cell division and for the maintenance of normal septation
YE0023	COG3078	GTPase activator activity
YE0024	COG0635	Involved in the biosynthesis of porphyrin-containing compound
YE0026	COG3852	Histidine kinase
YE0030	COG1011	Hydrolase
YE0031	COG1295	ribonuclease BN
YE0032	COG1490	D-aminoacyl-tRNA deacylase activity
YE0033	COG0456	acetyltransferase
YE0040	COG2982	Protein involved in outer membrane biogenesis
YE0041	COG2233	PERMEase
YE0042	COG0786	glutamate:sodium symporter activity
YE0043	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
YE0044	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
YE0045	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
YE0046	COG1758	RNA polymerase activity
YE0048	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
YE0049	COG2860	membrane
YE0051	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
YE0052	COG1024	Enoyl-CoA hydratase
YE0053	COG5001	Diguanylate cyclase
YE0057	COG1561	YicC-like family, N-terminal region
YE0058	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
YE0059	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
YE0060	COG1309	transcriptional regulator
YE0061	COG0756	dUTP diphosphatase activity
YE0062	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
YE0063	COG2003	Belongs to the UPF0758 family
YE0064	COG0227	Belongs to the bacterial ribosomal protein bL28 family
YE0065	COG0267	Belongs to the bacterial ribosomal protein bL33 family
YE0066	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
YE0067	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
YE0069	COG1519	Transferase
YE0070	COG0859	PFAM glycosyl transferase family 9
YE0071	COG0859	PFAM glycosyl transferase family 9
YE0072	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
YE0073	COG0156	8-amino-7-oxononanoate synthase activity
YE0074	COG1063	alcohol dehydrogenase
YE0075	COG2861	carbohydrate metabolic process
YE0076	COG4942	peptidase
YE0077	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
YE0078	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
YE0079	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
YE0080	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
YE0081	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
YE0082	COG1045	serine acetyltransferase
YE0083	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
YE0084	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
YE0084	COG2169	Transcriptional regulator
YE0085	COG2205	protein histidine kinase activity
YE0086	COG0745	RESPONSE REGULATOR receiver
YE0087	COG3678	ATP-independent chaperone mediated protein folding
YE0088	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
YE0089	COG0205	6-phosphofructokinase activity
YE0090	COG3385	transposase activity
YE0091	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
YE0093	COG0149	triose-phosphate isomerase activity
YE0095	COG3152	Membrane
YE0097	COG2814	Major facilitator Superfamily
YE0098	COG1494	fructose-1,6-bisphosphatase
YE0099	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
YE0100	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
YE0101	COG3074	FtsZ-dependent cytokinesis
YE0102	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
YE0103	COG1575	Belongs to the MenA family. Type 1 subfamily
YE0104	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
YE0105	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
YE0106	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
YE0107	COG1609	Transcriptional regulator
YE0108	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
YE0109	COG0254	rRNA binding
YE0110	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
YE0111	COG0626	cystathionine gamma-synthase activity
YE0112	COG0460	homoserine dehydrogenase
YE0112	COG0527	aspartate kinase activity
YE0116	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
YE0120	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
YE0121	COG0165	Argininosuccinate lyase
YE0122	COG1629	transport
YE0131	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
YE0132	COG0678	peroxiredoxin activity
YE0132	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
YE0134	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
YE0135	COG1309	transcriptional regulator
YE0138	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
YE0140	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
YE0141	COG1879	ABC-type sugar transport system periplasmic component
YE0142	COG1129	ABC transporter
YE0143	COG1172	Belongs to the binding-protein-dependent transport system permease family
YE0144	COG1172	Belongs to the binding-protein-dependent transport system permease family
YE0145	COG0583	DNA-binding transcription factor activity
YE0146	COG3085	chromosome segregation
YE0149	COG3978	acetolactate synthase activity
YE0150	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
YE0151	COG0129	dihydroxy-acid dehydratase activity
YE0152	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
YE0154	COG0583	DNA-binding transcription factor activity
YE0155	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
YE0157	COG3121	Chaperone
YE0160	COG3121	Chaperone
YE0162	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
YE0165	COG0248	Ppx GppA phosphatase
YE0167	COG3118	belongs to the thioredoxin family
YE0168	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
YE0169	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
YE0170	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
YE0171	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
YE0172	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
YE0173	COG1088	dTDP-glucose 4,6-dehydratase activity
YE0174	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
YE0175	COG0456	acetyltransferase
YE0176	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
YE0177	COG2244	polysaccharide biosynthetic process
YE0178	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
YE0184	COG3071	HemY protein
YE0185	COG2959	enzyme of heme biosynthesis
YE0186	COG1587	Uroporphyrinogen-III synthase
YE0187	COG0181	hydroxymethylbilane synthase activity
YE0189	COG3072	Adenylate cyclase
YE0190	COG1965	Belongs to the frataxin family
YE0192	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
YE0193	COG3159	Protein conserved in bacteria
YE0194	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
YE0195	COG1011	Hydrolase
YE0196	COG0210	DNA helicase
YE0198	COG5441	Belongs to the UPF0261 family
YE0199	COG5564	TIM-barrel signal transduction protein
YE0202	COG2050	protein possibly involved in aromatic compounds catabolism
YE0203	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
YE0204	COG0514	ATP-dependent DNA helicase (RecQ)
YE0205	COG1280	lysine exporter protein (LysE YggA)
YE0207	COG2267	carboxylic ester hydrolase activity
YE0208	COG0561	phosphatase activity
YE0209	COG0584	glycerophosphoryl diester phosphodiesterase
YE0210	COG2271	Major facilitator Superfamily
YE0212	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
YE0213	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
YE0214	COG0247	lactate metabolic process
YE0216	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
YE0217	COG0425	Belongs to the sulfur carrier protein TusA family
YE0218	COG2217	Heavy metal translocating P-type atpase
YE0219	COG3714	YhhN family
YE0223	COG3776	membrane
YE0224	COG0742	ribosomal rna small subunit methyltransferase
YE0225	COG0552	protein localization to endoplasmic reticulum
YE0226	COG2884	Cell division ATP-binding protein ftsE
YE0227	COG2177	Part of the ABC transporter FtsEX involved in
YE0230	COG0683	leucine binding
YE0232	COG4177	L-phenylalanine transmembrane transporter activity
YE0234	COG0410	ABC transporter
YE0241	COG1653	transport
YE0242	COG1175	transmembrane transport
YE0243	COG0395	ABC-type sugar transport system, permease component
YE0244	COG3842	ATPase activity
YE0245	COG0584	glycerophosphoryl diester phosphodiesterase
YE0246	COG0679	Auxin Efflux Carrier
YE0247	COG0697	spore germination
YE0248	COG0583	DNA-binding transcription factor activity
YE0249	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
YE0250	COG0412	Dienelactone hydrolase
YE0253	COG1966	Carbon starvation protein
YE0254	COG0586	Pfam SNARE associated Golgi protein
YE0255	COG1322	Protein conserved in bacteria
YE0256	COG2226	methyltransferase
YE0258	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
YE0259	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
YE0260	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
YE0261	COG0805	protein transport
YE0265	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
YE0267	COG0183	Belongs to the thiolase family
YE0268	COG1250	3-hydroxyacyl-CoA dehydrogenase
YE0268	COG1024	Enoyl-CoA hydratase
YE0269	COG0006	proline dipeptidase activity
YE0272	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
YE0275	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
YE0275	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
YE0276	COG1072	(Pantothenic acid kinase))
YE0278	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
YE0280	COG0250	Participates in transcription elongation, termination and antitermination
YE0281	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
YE0282	COG0081	regulation of translation
YE0283	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
YE0284	COG0222	ribosome binding
YE0286	COG0085	RNA polymerase activity
YE0287	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
YE0288	COG3385	transposase activity
YE0290	COG2022	thiamine diphosphate biosynthetic process
YE0290A	COG2104	thiamine diphosphate biosynthetic process
YE0291	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
YE0295	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
YE0296	COG2816	NAD+ diphosphatase activity
YE0297	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
YE0298	COG1515	deoxyribonuclease V activity
YE0302	COG0151	Belongs to the GarS family
YE0303	COG0138	bifunctional purine biosynthesis protein purh
YE0307	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
YE0308	COG3162	membrane
YE0309	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
YE0310	COG1301	dicarboxylic acid transport
YE0311	COG2197	response regulator
YE0314	COG0425	Belongs to the sulfur carrier protein TusA family
YE0317	COG3712	iron ion homeostasis
YE0318	COG4771	TonB-dependent receptor
YE0319	COG4178	(ABC) transporter
YE0320	COG0612	Peptidase, M16
YE0321	COG2161	toxin-antitoxin pair type II binding
YE0322	COG3264	Mechanosensitive ion channel
YE0322	COG1511	domain protein
YE0323	COG4774	siderophore transport
YE0324	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
YE0327	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
YE0328	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
YE0329	COG4558	Periplasmic binding protein
YE0330	COG3720	iron ion transport
YE0334	COG3721	Heme iron utilization protein
YE0336	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
YE0337	COG0814	amino acid
YE0338	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
YE0339	COG1882	Formate acetyltransferase
YE0341	COG1028	Short-chain dehydrogenase reductase Sdr
YE0342	COG0667	Aldo Keto reductase
YE0346	COG1309	transcriptional regulator
YE0347	COG1929	Belongs to the glycerate kinase type-1 family
YE0348	COG4232	protein-disulfide reductase activity
YE0350	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
YE0353	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
YE0354	COG0459	protein refolding
YE0357	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
YE0361	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
YE0362	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
YE0363	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
YE0364	COG1053	succinate dehydrogenase
YE0365	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
YE0366	COG1511	domain protein
YE0366	COG3264	Mechanosensitive ion channel
YE0367	COG0688	phosphatidylethanolamine metabolic process
YE0368	COG1162	GTPase activity
YE0369	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
YE0371	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
YE0372	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
YE0372	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
YE0373	COG0802	atpase or kinase
YE0374	COG0860	N-Acetylmuramoyl-L-alanine amidase
YE0375	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
YE0376	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
YE0377	COG1923	regulation of RNA biosynthetic process
YE0378	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
YE0379	COG0330	HflC and HflK could
YE0380	COG0330	HflC and HflK could
YE0381	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
YE0382	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
YE0383	COG1959	2 iron, 2 sulfur cluster binding
YE0384	COG0557	exoribonuclease II activity
YE0385	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
YE0386	COG1960	acyl-CoA dehydrogenase activity
YE0387	COG3650	response to hydrogen peroxide
YE0388	COG1073	alpha beta
YE0392	COG0360	Binds together with S18 to 16S ribosomal RNA
YE0393	COG2965	DNA replication, synthesis of RNA primer
YE0394	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
YE0395	COG0359	binds to the 23S rRNA
YE0397	COG3061	Opacity-associated protein A
YE0398	COG0545	Peptidyl-prolyl cis-trans isomerase
YE0399	COG0737	Belongs to the 5'-nucleotidase family
YE0400	COG1218	3'(2'),5'-bisphosphate nucleotidase
YE0401	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
YE0403	COG1253	flavin adenine dinucleotide binding
YE0404	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
YE0405	COG0729	surface antigen
YE0407	COG2105	PFAM AIG2 family protein
YE0408	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
YE0410	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
YE0411	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
YE0413	COG1438	arginine binding
YE0414	COG0039	L-malate dehydrogenase activity
YE0414a	COG3423	Transcriptional regulator
YE0417	COG0142	geranyltranstransferase activity
YE0418	COG0261	This protein binds to 23S rRNA in the presence of protein L20
YE0419	COG0211	Belongs to the bacterial ribosomal protein bL27 family
YE0420	COG0697	spore germination
YE0421	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
YE0422	COG0642	Histidine kinase
YE0423	COG0745	RESPONSE REGULATOR receiver
YE0424	COG2027	D-alanyl-D-alanine carboxypeptidase
YE0426	COG1534	Rna-binding protein
YE0427	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
YE0429	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
YE0430	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
YE0431	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
YE0432	COG0779	Required for maturation of 30S ribosomal subunits
YE0433	COG0195	Participates in both transcription termination and antitermination
YE0434	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
YE0435	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
YE0436	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
YE0437	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
YE0438	COG1185	polyribonucleotide nucleotidyltransferase activity
YE0440	COG0513	Belongs to the DEAD box helicase family
YE0442	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
YE0443	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
YE0444	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
YE0447	COG0814	amino acid
YE0448	COG3681	Belongs to the UPF0597 family
YE0449	COG0826	peptidase U32
YE0450	COG0826	peptidase U32
YE0451	COG3154	lipid carrier protein
YE0452	COG3153	acetyltransferase
YE0453	COG2827	Endonuclease containing a URI domain
YE0454	COG0531	amino acid
YE0455	COG1982	Orn Lys Arg decarboxylase major
YE0460	COG1653	transport
YE0461	COG1175	transmembrane transport
YE0462	COG0395	ABC-type sugar transport system, permease component
YE0463	COG3842	ATPase activity
YE0465	COG3787	Belongs to the UPF0306 family
YE0468	COG0702	epimerase
YE0469	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
YE0470	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
YE0471	COG3454	Phosphonate metabolism
YE0472	COG4778	phosphonate C-P lyase system protein PhnL
YE0473	COG4107	phosphonate C-P lyase system protein PhnK
YE0474	COG3627	carbon phosphorus lyase activity
YE0475	COG3626	phosphonate metabolism
YE0476	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
YE0477	COG3624	Phosphonate C-P lyase system protein PhnG
YE0478	COG2188	Transcriptional regulator
YE0483	COG0583	DNA-binding transcription factor activity
YE0484	COG2249	NAD(P)H dehydrogenase (quinone) activity
YE0487	COG4608	Belongs to the ABC transporter superfamily
YE0488	COG0444	Belongs to the ABC transporter superfamily
YE0489	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
YE0490	COG0601	transmembrane transport
YE0492	COG2731	YhcH YjgK YiaL family protein
YE0495	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
YE0499	COG2927	DNA polymerase III (CHI subunit)
YE0500	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
YE0501	COG0795	lipopolysaccharide-transporting ATPase activity
YE0502	COG0795	lipopolysaccharide-transporting ATPase activity
YE0510	COG3077	Addiction module antitoxin, RelB DinJ family
YE0513	COG0454	-acetyltransferase
YE0523	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
YE0524	COG1830	Aldolase
YE0525	COG1879	ABC-type sugar transport system periplasmic component
YE0526	COG1172	Belongs to the binding-protein-dependent transport system permease family
YE0527	COG1172	Belongs to the binding-protein-dependent transport system permease family
YE0528	COG1129	ABC transporter
YE0529	COG2390	Transcriptional regulator
YE0530	COG1070	Carbohydrate kinase
YE0531	COG0859	PFAM glycosyl transferase family 9
YE0535	COG2235	arginine
YE0536	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
YE0537	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
YE0538	COG3385	transposase activity
YE0540	COG2376	Dihydroxyacetone kinase
YE0541	COG1461	Dihydroxyacetone kinase
YE0542	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
YE0542	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
YE0542	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
YE0544	COG2192	nodulation
YE0550	COG3284	Transcriptional regulator
YE0556	COG4772	TonB-dependent receptor
YE0559	COG0583	DNA-binding transcription factor activity
YE0560	COG0667	Aldo Keto reductase
YE0561	COG2813	Specifically methylates the guanine in position
YE0562	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
YE0563	COG0456	acetyltransferase
YE0564	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
YE0565	COG2823	Periplasmic or secreted lipoprotein
YE0567	COG4667	esterase of the alpha-beta hydrolase superfamily
YE0568	COG0084	hydrolase, TatD family'
YE0569	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
YE0571	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
YE0572	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
YE0574	COG0813	purine-nucleoside phosphorylase activity
YE0575	COG3550	peptidyl-serine autophosphorylation
YE0576	COG3726	membrane protein affecting hemolysin expression
YE0578	COG0560	Phosphoserine phosphatase
YE0581	COG0604	alcohol dehydrogenase
YE0584	COG0488	(ABC) transporter
YE0585	COG2885	chlorophyll binding
YE0586	COG2199	diguanylate cyclase activity
YE0588	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
YE0589	COG0741	lytic transglycosylase activity
YE0590	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
YE0591	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
YE0592	COG0406	alpha-ribazole phosphatase activity
YE0593	COG2207	Transcriptional regulator
YE0593	COG3708	Transcriptional regulator
YE0594	COG3045	CreA protein
YE0595	COG0745	RESPONSE REGULATOR receiver
YE0599	COG3385	transposase activity
YE0601	COG0083	homoserine kinase activity
YE0603	COG3022	response to hydroperoxide
YE0604	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
YE0605	COG0521	Mo-molybdopterin cofactor biosynthetic process
YE0608	COG1584	GPR1 FUN34 yaaH family protein
YE0609	COG0443	Heat shock 70 kDa protein
YE0610	COG0484	heat shock protein binding
YE0611	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
YE0612	COG0583	DNA-binding transcription factor activity
YE0613	COG0268	Binds directly to 16S ribosomal RNA
YE0615	COG0196	riboflavin kinase activity
YE0616	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
YE0617	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
YE0618	COG1047	Peptidyl-prolyl cis-trans
YE0619	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
YE0620	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
YE0622	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
YE0623	COG1280	lysine exporter protein (LysE YggA)
YE0624	COG2966	Psort location CytoplasmicMembrane, score
YE0625	COG3610	response to peptide
YE0626	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
YE0628	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
YE0629	COG2967	ApaG domain
YE0630	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
YE0631	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
YE0633	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
YE0634	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
YE0635	COG0564	pseudouridine synthase activity
YE0636	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
YE0637	COG0417	DNA replication proofreading
YE0639	COG0586	Pfam SNARE associated Golgi protein
YE0641	COG1178	ABC-type Fe3 transport system permease component
YE0642	COG4143	(ABC) transporter
YE0644	COG4533	DNA binding
YE0645	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
YE0646	COG1882	Formate acetyltransferase
YE0647	COG3077	Addiction module antitoxin, RelB DinJ family
YE0648	COG2814	Major facilitator Superfamily
YE0649	COG0814	amino acid
YE0650	COG3033	Beta-eliminating lyase
YE0652	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
YE0653	COG0473	3-isopropylmalate dehydrogenase activity
YE0654	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
YE0656	COG1022	Amp-dependent synthetase and ligase
YE0658	COG0028	Belongs to the TPP enzyme family
YE0663	COG2001	Belongs to the MraZ family
YE0664	COG0275	rRNA processing
YE0665	COG3116	cell division
YE0666	COG0768	penicillin binding
YE0667	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
YE0668	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
YE0669	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
YE0671	COG0772	Belongs to the SEDS family
YE0672	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
YE0673	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
YE0675	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
YE0676	COG0849	cell division
YE0677	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
YE0681	COG0653	protein targeting
YE0682	COG0494	nUDIX hydrolase
YE0683	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
YE0684	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
YE0686	COG0516	GMP reductase activity
YE0688	COG1459	type II secretion system
YE0689	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
YE0690	COG4969	Belongs to the N-Me-Phe pilin family
YE0693	COG3725	Membrane protein required for beta-lactamase induction
YE0695	COG1113	amino acid transport
YE0698	COG2186	Transcriptional regulator
YE0699	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
YE0701	COG0508	dehydrogenase complex catalyzes the overall conversion of
YE0702	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
YE0706	COG3112	Uncharacterised protein family (UPF0231)
YE0707	COG0697	spore germination
YE0709	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
YE0710	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
YE0712	COG2132	Multicopper oxidase
YE0713	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
YE0714	COG0288	reversible hydration of carbon dioxide
YE0715	COG1131	(ABC) transporter
YE0716	COG0842	Transport permease protein
YE0717	COG0726	polysaccharide deacetylase
YE0718	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
YE0719	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
YE0720	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
YE0722	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
YE0726	COG1489	DNA binding
YE0727	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
YE0728	COG1643	Atp-dependent helicase
YE0729	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
YE0730	COG1120	ATPase activity
YE0731	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
YE0732	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
YE0733	COG2223	nitrite transmembrane transporter activity
YE0734	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
YE0736	COG0316	Belongs to the HesB IscA family
YE0737	COG2860	membrane
YE0739	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
YE0740	COG0232	Belongs to the dGTPase family. Type 2 subfamily
YE0741	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
YE0742	COG3437	response regulator, receiver
YE0742	COG4999	Histidine kinase
YE0742	COG3850	Histidine kinase
YE0742	COG2205	protein histidine kinase activity
YE0743	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
YE0744	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
YE0745	COG3956	TIGRFAM MazG family protein
YE0746	COG0504	CTP synthase activity
YE0747	COG0148	phosphopyruvate hydratase activity
YE0753	COG0602	queuosine metabolic process
YE0754	COG0720	synthase
YE0755	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
YE0756	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
YE0757	COG0175	sulfate reduction
YE0760	COG2234	aminopeptidase activity
YE0761	COG1648	precorrin-2 dehydrogenase activity
YE0761	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
YE0762	COG0175	sulfate reduction
YE0763	COG2895	sulfate adenylyltransferase (ATP) activity
YE0764	COG0529	Catalyzes the synthesis of activated sulfate
YE0768	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
YE0770	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
YE0771	COG0585	pseudouridine synthase activity
YE0772	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
YE0773	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
YE0774	COG4942	peptidase
YE0774	COG1388	LysM domain
YE0775	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
YE0776	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
YE0781	COG3188	usher protein
YE0782	COG3121	Chaperone
YE0784	COG3539	Fimbrial protein
YE0785	COG3539	Fimbrial protein
YE0792	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
YE0794	COG1538	Outer membrane efflux protein
YE0798	COG1028	Short-chain dehydrogenase reductase Sdr
YE0799	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
YE0800	COG3048	D-serine ammonia-lyase activity
YE0801	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
YE0802	COG0765	amino acid transport
YE0803	COG0765	amino acid transport
YE0804	COG1126	abc transporter atp-binding protein
YE0805	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
YE0806	COG3665	Urea carboxylase-associated protein
YE0808	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
YE0809	COG0640	Transcriptional regulator
YE0816	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
YE0816	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
YE0818	COG1879	ABC-type sugar transport system periplasmic component
YE0820	COG1129	ABC transporter
YE0821	COG1172	Belongs to the binding-protein-dependent transport system permease family
YE0822	COG3959	Transketolase, thiamine diphosphate binding domain
YE0823	COG3958	Transketolase
YE0824	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
YE0829	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
YE0833	COG2137	regulation of response to DNA damage stimulus
YE0834	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
YE0835	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
YE0836	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
YE0837	COG1238	metal cluster binding
YE0838	COG2918	glutathione biosynthetic process
YE0839	COG1854	S-ribosylhomocysteine lyase activity
YE0840	COG4536	flavin adenine dinucleotide binding
YE0841	COG4137	Cytochrome C assembly protein
YE0842	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
YE0843	COG0228	four-way junction DNA binding
YE0844	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
YE0845	COG0336	Belongs to the RNA methyltransferase TrmD family
YE0846	COG0335	large ribosomal subunit rRNA binding
YE0847	COG3137	Salt-induced outer membrane protein
YE0848	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
YE0849	COG3279	Response regulator of the LytR AlgR family
YE0850	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
YE0851	COG1605	Chorismate mutase
YE0851	COG0287	Prephenate dehydrogenase
YE0852	COG1605	Chorismate mutase
YE0852	COG0077	Prephenate dehydratase
YE0853	COG4974	Belongs to the 'phage' integrase family
YE0854	COG1396	sequence-specific DNA binding
YE0866	COG4695	Portal protein
YE0889	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
YE0890	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
YE0891	COG0564	pseudouridine synthase activity
YE0892	COG1496	oxidoreductase activity
YE0893	COG0542	response to heat
YE0899	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
YE0902	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
YE0910	COG1028	Short-chain dehydrogenase reductase Sdr
YE0912	COG0656	L-ascorbic acid biosynthetic process
YE0914	COG0583	DNA-binding transcription factor activity
YE0917	COG3021	interspecies interaction between organisms
YE0918	COG1388	LysM domain
YE0918	COG0741	lytic transglycosylase activity
YE0919	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
YE0920	COG2226	methyltransferase
YE0921	COG0328	RNA-DNA hybrid ribonuclease activity
YE0922	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
YE0923	COG2113	Glycine betaine
YE0924	COG4176	ABC-type proline glycine betaine transport system permease component
YE0925	COG4175	Glycine betaine
YE0926	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
YE0928	COG1780	Probably involved in ribonucleotide reductase function
YE0929	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
YE0930	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
YE0932	COG4575	ribosome binding
YE0935	COG2207	Transcriptional regulator
YE0940	COG1278	Cold shock
YE0948	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
YE0949	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
YE0951	COG0831	urea catabolic process
YE0952	COG0832	Belongs to the urease beta subunit family
YE0953	COG0804	urea catabolic process
YE0954	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
YE0955	COG0830	nickel cation binding
YE0956	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
YE0957	COG0829	nickel cation binding
YE0958	COG4413	Urea transporter
YE0959	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
YE0961	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
YE0965	COG0667	Aldo Keto reductase
YE0966	COG2133	pyrroloquinoline quinone binding
YE0967	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
YE0968	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
YE0969	COG2723	6-phospho-beta-galactosidase activity
YE0970	COG1447	Phosphotransferase system cellobiose-specific component IIA
YE0971	COG1917	Cupin 2, conserved barrel domain protein
YE0971	COG2169	Transcriptional regulator
YE0972	COG3394	polysaccharide catabolic process
YE0973	COG0659	secondary active sulfate transmembrane transporter activity
YE0974	COG0582	viral genome integration into host DNA
YE0977	COG0582	viral genome integration into host DNA
YE0993	COG0582	viral genome integration into host DNA
YE0994	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
YE0995	COG2867	negative regulation of translational initiation
YE0997	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
YE0998	COG0497	DNA recombination
YE0999	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
YE1000	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
YE1002	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
YE1003	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
YE1007	COG0513	Belongs to the DEAD box helicase family
YE1008	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
YE1009	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
YE1011	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
YE1013	COG3086	response to oxidative stress
YE1015	COG0481	GTPase activity
YE1017	COG0571	ribonuclease III activity
YE1018	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
YE1019	COG1381	Involved in DNA repair and RecF pathway recombination
YE1020	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
YE1021	COG0736	holo-[acyl-carrier-protein] synthase activity
YE1023	COG2610	gluconate transmembrane transporter activity
YE1024	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
YE1025	COG1737	Transcriptional regulator
YE1026A	COG3423	Transcriptional regulator
YE1028	COG0560	Phosphoserine phosphatase
YE1031	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
YE1035	COG2205	protein histidine kinase activity
YE1036	COG3170	Tfp pilus assembly protein FimV
YE1037	COG2204	response regulator
YE1038	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
YE1038	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
YE1039	COG0347	Belongs to the P(II) protein family
YE1042	COG1735	metal-dependent hydrolase with the TIM-barrel fold
YE1043	COG3457	Alanine racemase
YE1045	COG2188	Transcriptional regulator
YE1046	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
YE1046	COG1017	nitric oxide dioxygenase activity
YE1047	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
YE1049	COG2814	Major facilitator Superfamily
YE1050	COG3711	transcriptional antiterminator
YE1051	COG3683	transport system, periplasmic component
YE1052	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
YE1055	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
YE1056	COG1959	2 iron, 2 sulfur cluster binding
YE1058	COG0822	iron-sulfur transferase activity
YE1059	COG0316	Belongs to the HesB IscA family
YE1060	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
YE1061	COG0443	Heat shock 70 kDa protein
YE1062	COG0633	Ferredoxin
YE1063	COG2975	iron-sulfur cluster assembly
YE1066	COG2373	Large extracellular alpha-helical protein
YE1067	COG4953	penicillin-binding protein 1C
YE1069	COG0105	UTP biosynthetic process
YE1070	COG0820	rRNA (adenine-C2-)-methyltransferase activity
YE1072	COG1426	Protein conserved in bacteria
YE1073	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
YE1074	COG0124	histidyl-tRNA synthetase
YE1075	COG2976	Protein conserved in bacteria
YE1076	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
YE1077	COG1160	GTP binding
YE1079	COG1645	bacterial-type flagellum-dependent swarming motility
YE1080	COG1570	exodeoxyribonuclease VII activity
YE1081	COG0517	IMP dehydrogenase activity
YE1081	COG0516	GMP reductase activity
YE1082	COG0519	Catalyzes the synthesis of GMP from XMP
YE1082	COG0518	GMP synthase (glutamine-hydrolyzing) activity
YE1088	COG0351	phosphomethylpyrimidine kinase
YE1093	COG1349	DNA-binding transcription factor activity
YE1094	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
YE1095	COG1028	Short-chain dehydrogenase reductase Sdr
YE1098	COG3730	PTS system glucitol sorbitol-specific
YE1099	COG1597	lipid kinase activity
YE1100	COG0826	peptidase U32
YE1103	COG3422	double-strand break repair
YE1104	COG0745	RESPONSE REGULATOR receiver
YE1105	COG2205	protein histidine kinase activity
YE1106	COG0477	Major facilitator Superfamily
YE1107	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
YE1109	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
YE1111	COG3539	Fimbrial protein
YE1113	COG3121	Chaperone
YE1115	COG0443	Heat shock 70 kDa protein
YE1116	COG5001	Diguanylate cyclase
YE1116	COG3447	MASE1 domain protein
YE1116	COG5002	protein histidine kinase activity
YE1117	COG2239	Acts as a magnesium transporter
YE1120	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
YE1122	COG2801	Transposase and inactivated derivatives
YE1123	COG2963	transposase activity
YE1124	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
YE1125	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
YE1127	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
YE1128	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
YE1129	COG2233	PERMEase
YE1130	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
YE1131	COG1393	Belongs to the ArsC family
YE1132	COG4783	chaperone-mediated protein folding
YE1133	COG0628	permease
YE1135	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
YE1136	COG2716	regulation of RNA biosynthetic process
YE1137	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
YE1138	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
YE1140	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
YE1141	COG2321	neutral zinc metallopeptidase
YE1142	COG2707	UPF0756 membrane protein
YE1143	COG1444	tRNA N-acetyltransferase activity
YE1144	COG0400	carboxylic ester hydrolase activity
YE1146	COG1876	peptidase activity
YE1147	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
YE1148	COG1393	Belongs to the ArsC family
YE1151	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
YE1153	COG2197	response regulator
YE1155	COG3062	negative regulation of establishment of protein localization
YE1156	COG0243	molybdopterin cofactor binding
YE1157	COG3043	anaerobic respiration
YE1158	COG3005	denitrification pathway
YE1161	COG0494	nUDIX hydrolase
YE1165	COG2197	response regulator
YE1167	COG1671	Belongs to the UPF0178 family
YE1168	COG0408	coproporphyrinogen oxidase activity
YE1169	COG0456	acetyltransferase
YE1184	COG0456	acetyltransferase
YE1185	COG3111	PFAM Bacterial OB fold (BOF) protein
YE1187	COG2837	iron assimilation
YE1188	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
YE1191	COG2731	YhcH YjgK YiaL family protein
YE1192	COG1737	Transcriptional regulator
YE1194	COG4150	thiosulfate binding
YE1195	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
YE1196	COG4208	sulfate ABC transporter
YE1200	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
YE1201	COG0745	RESPONSE REGULATOR receiver
YE1202	COG2205	protein histidine kinase activity
YE1206	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
YE1207	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
YE1211	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
YE1212	COG3530	Putative quorum-sensing-regulated virulence factor
YE1215	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
YE1217	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
YE1219	COG1914	H( )-stimulated, divalent metal cation uptake system
YE1221	COG0667	Aldo Keto reductase
YE1222	COG3961	Belongs to the TPP enzyme family
YE1225	COG0837	glucose binding
YE1226	COG2223	nitrite transmembrane transporter activity
YE1227	COG3279	Response regulator of the LytR AlgR family
YE1228	COG3275	phosphorelay sensor kinase activity
YE1231	COG0436	Aminotransferase
YE1232	COG3038	cytochrome b561
YE1233	COG1598	PFAM Uncharacterised protein family UPF0150
YE1238	COG1280	lysine exporter protein (LysE YggA)
YE1242	COG2951	lytic endotransglycosylase activity
YE1243	COG0531	amino acid
YE1247	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
YE1248	COG1127	ABC transporter
YE1252	COG2755	lipolytic protein G-D-S-L family
YE1252	COG0657	acetylesterase activity
YE1253	COG3038	cytochrome b561
YE1254	COG2353	YceI-like domain
YE1255	COG1609	Transcriptional regulator
YE1256	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
YE1256	COG1263	PTS System
YE1257	COG2723	6-phospho-beta-galactosidase activity
YE1259	COG1695	Transcriptional regulator
YE1260	COG2824	Alkylphosphonate utilization operon protein PhnA
YE1261	COG0582	viral genome integration into host DNA
YE1262	COG2116	formate transmembrane transporter activity
YE1264	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
YE1265	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
YE1266	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
YE1267	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
YE1268	COG1138	Cytochrome C-type biogenesis protein
YE1269	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
YE1270	COG3088	subunit of a heme lyase
YE1270	COG4235	cytochrome complex assembly
YE1271	COG4235	cytochrome complex assembly
YE1271	COG3088	subunit of a heme lyase
YE1275	COG3691	Protein conserved in bacteria
YE1276	COG0183	Belongs to the thiolase family
YE1277	COG1250	3-hydroxyacyl-CoA dehydrogenase
YE1277	COG1024	Enoyl-CoA hydratase
YE1278	COG2062	phosphohistidine phosphatase, SixA
YE1279	COG2840	Smr protein MutS2
YE1280	COG2890	protein-(glutamine-N5) methyltransferase activity
YE1281	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
YE1282	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
YE1283	COG0730	response to heat
YE1284	COG3101	peptidyl-lysine hydroxylation
YE1286	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
YE1286	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
YE1287	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
YE1289	COG1794	racemase activity, acting on amino acids and derivatives
YE1291	COG1447	Phosphotransferase system cellobiose-specific component IIA
YE1292	COG2723	6-phospho-beta-galactosidase activity
YE1293	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
YE1295	COG1609	Transcriptional regulator
YE1297	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
YE1302	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
YE1303	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
YE1304	COG0697	spore germination
YE1305	COG0697	spore germination
YE1307	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
YE1308	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
YE1310	COG0586	Pfam SNARE associated Golgi protein
YE1311	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
YE1312	COG0285	dihydrofolate synthase activity
YE1313	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
YE1314	COG1286	toxin biosynthetic process
YE1315	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
YE1317	COG0163	prenyltransferase activity
YE1318	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
YE1319	COG4215	(ABC) transporter
YE1320	COG4160	amino acid transport
YE1321	COG4598	ABC transporter
YE1323	COG1090	epimerase
YE1325	COG0622	Phosphoesterase
YE1326	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
YE1328	COG3037	sugar-specific permease SgaT UlaA
YE1330	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
YE1331	COG1609	Transcriptional regulator
YE1333	COG0857	belongs to the CobB CobQ family
YE1333	COG0280	phosphate acetyltransferase
YE1335	COG3092	negative regulation of chromosome organization
YE1336	COG3013	Belongs to the UPF0304 family
YE1337	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
YE1339	COG0471	metal ion transport
YE1339	COG0490	domain, Protein
YE1340	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
YE1341	COG0436	Aminotransferase
YE1343	COG0583	DNA-binding transcription factor activity
YE1344	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
YE1345	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
YE1346	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
YE1346	COG0649	NAD binding
YE1349	COG1034	ATP synthesis coupled electron transport
YE1350	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
YE1351	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
YE1352	COG0839	Belongs to the complex I subunit 6 family
YE1353	COG0713	ATP synthesis coupled electron transport
YE1354	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
YE1355	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
YE1356	COG1007	ATP synthesis coupled electron transport
YE1362	COG3265	gluconokinase activity
YE1363	COG1028	Short-chain dehydrogenase reductase Sdr
YE1364	COG1609	Transcriptional regulator
YE1365	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
YE1367	COG4702	Belongs to the UPF0303 family
YE1368	COG0129	dihydroxy-acid dehydratase activity
YE1371	COG4575	ribosome binding
YE1373	COG1169	isochorismate synthase
YE1375	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
YE1376	COG0596	Alpha beta hydrolase
YE1377	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
YE1378	COG1441	menaquinone biosynthetic process
YE1382	COG0814	amino acid
YE1390	COG4574	serine-type endopeptidase inhibitor activity
YE1391	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
YE1393	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
YE1394	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
YE1396	COG0784	Response regulator, receiver
YE1396	COG2205	protein histidine kinase activity
YE1397	COG2197	response regulator
YE1398	COG2198	Histidine kinase
YE1398	COG0642	Histidine kinase
YE1399	COG2223	nitrite transmembrane transporter activity
YE1402	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
YE1415	COG1737	Transcriptional regulator
YE1416	COG2190	(PTS) system
YE1416	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
YE1416	COG1263	PTS System
YE1417	COG2723	6-phospho-beta-galactosidase activity
YE1420	COG3082	Protein of unknown function (DUF1414)
YE1421	COG3081	Nucleoid-associated protein
YE1422	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
YE1423	COG1061	Type III restriction enzyme res subunit
YE1424	COG1187	pseudouridine synthase activity
YE1425	COG2814	Major facilitator Superfamily
YE1427	COG4172	Belongs to the ABC transporter superfamily
YE1428	COG4239	(ABC) transporter, permease
YE1429	COG4174	ABC transporter (Permease)
YE1430	COG4166	transmembrane transport
YE1431	COG2200	EAL domain
YE1433	COG0791	NLP P60 protein
YE1434	COG0671	phosphoesterase, PA-phosphatase related
YE1435	COG0523	cobalamin synthesis protein
YE1437	COG2186	Transcriptional regulator
YE1438	COG0246	Mannitol dehydrogenase
YE1440	COG1312	Catalyzes the dehydration of D-mannonate
YE1441	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
YE1444	COG0243	molybdopterin cofactor binding
YE1445	COG3005	denitrification pathway
YE1448	COG1105	Belongs to the carbohydrate kinase PfkB family
YE1449	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
YE1449	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
YE1449	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
YE1450	COG3710	Transcriptional regulator
YE1455	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
YE1456	COG2855	membrane
YE1457	COG0583	DNA-binding transcription factor activity
YE1458	COG0833	amino acid
YE1459	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
YE1461	COG4771	TonB-dependent receptor
YE1463	COG0625	glutathione transferase activity
YE1468	COG2011	ABC-type metal ion transport system permease component
YE1469	COG0626	cystathionine gamma-synthase activity
YE1471	COG1686	Belongs to the peptidase S11 family
YE1472	COG1760	l-serine dehydratase
YE1473	COG0814	amino acid
YE1474	COG1349	DNA-binding transcription factor activity
YE1475	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
YE1476	COG0671	phosphoesterase, PA-phosphatase related
YE1478	COG2985	domain, Protein
YE1478	COG0569	domain protein
YE1484	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
YE1485	COG3842	ATPase activity
YE1486	COG1176	ABC-type spermidine putrescine transport system, permease component I
YE1487	COG1177	transmembrane transport
YE1490	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
YE1491	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
YE1493	COG4160	amino acid transport
YE1494	COG4215	(ABC) transporter
YE1495	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
YE1496	COG1126	abc transporter atp-binding protein
YE1503	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
YE1504	COG0702	epimerase
YE1505	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
YE1507	COG0028	Belongs to the TPP enzyme family
YE1509	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
YE1510	COG1151	hydroxylamine reductase activity
YE1511	COG2431	L-lysine efflux transmembrane transporter activity
YE1512	COG3593	DNA synthesis involved in DNA repair
YE1513	COG2990	Protein conserved in bacteria
YE1514	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
YE1516	COG1278	Cold shock
YE1517	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
YE1518	COG0542	response to heat
YE1519	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
YE1520	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
YE1521	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
YE1523	COG0492	ferredoxin-NADP+ reductase activity
YE1524	COG1522	sequence-specific DNA binding
YE1525	COG3107	peptidoglycan biosynthetic process
YE1525	COG1674	ftsk spoiiie
YE1526	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
YE1527	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
YE1528	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
YE1530	COG2814	Major facilitator Superfamily
YE1531	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
YE1532	COG1882	Formate acetyltransferase
YE1533	COG2116	formate transmembrane transporter activity
YE1534	COG1944	ATP diphosphatase activity
YE1535	COG0252	asparaginase activity
YE1536	COG2323	membrane
YE1537	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
YE1538	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
YE1539	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
YE1540	COG0539	negative regulation of cytoplasmic translation
YE1541	COG0776	regulation of translation
YE1542	COG0658	competence protein
YE1542	COG2333	competence protein COMEC
YE1544	COG1663	tetraacyldisaccharide 4'-kinase activity
YE1545	COG5383	Protein conserved in bacteria
YE1547	COG1278	Cold shock
YE1549	COG2835	tetraacyldisaccharide 4'-kinase activity
YE1550	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
YE1551	COG3173	Aminoglycoside phosphotransferase
YE1552	COG1434	Gram-negative-bacterium-type cell wall biogenesis
YE1553	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
YE1554	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
YE1556	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
YE1557	COG2989	Protein conserved in bacteria
YE1558	COG3108	Peptidase M15
YE1559	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
YE1560	COG2200	EAL domain
YE1561	COG1448	Aminotransferase
YE1562	COG3385	transposase activity
YE1564	COG0017	Asparaginyl-tRNA synthetase
YE1565	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
YE1567	COG0308	aminopeptidase N
YE1568	COG0167	dihydroorotate dehydrogenase activity
YE1570	COG0633	Ferredoxin
YE1570	COG3217	Mosc domain protein beta barrel domain protein
YE1571	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
YE1571	COG0116	Belongs to the methyltransferase superfamily
YE1572	COG0488	(ABC) transporter
YE1573	COG2995	paraquat-inducible protein a
YE1574	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
YE1574	COG3008	intermembrane lipid transfer
YE1575	COG3009	Protein conserved in bacteria
YE1576	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
YE1578	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
YE1579	COG1067	ATP-dependent peptidase activity
YE1580	COG3120	sequence-specific DNA binding
YE1582	COG5404	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
YE1583	COG3070	regulator of competence-specific genes
YE1584	COG1289	transmembrane transporter activity
YE1585	COG3304	Inner membrane component domain
YE1586	COG0210	DNA helicase
YE1587	COG1803	Methylglyoxal synthase
YE1589	COG1832	CoA-binding protein
YE1590	COG2963	transposase activity
YE1591	COG2801	Transposase and inactivated derivatives
YE1592	COG3785	DNA binding
YE1593	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
YE1596	COG1254	Belongs to the acylphosphatase family
YE1597	COG2920	part of a sulfur-relay system
YE1598	COG4235	cytochrome complex assembly
YE1599	COG2771	luxR family
YE1600	COG3916	Acyl-homoserine-lactone synthase
YE1602	COG3263	regulation of cellular component size
YE1605	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
YE1606	COG2943	transferase activity, transferring hexosyl groups
YE1606a	COG5645	(Lipo)protein
YE1610	COG2814	Major facilitator Superfamily
YE1611	COG2259	Doxx family
YE1612	COG1560	Kdo2-lipid A biosynthetic process
YE1619	COG1054	Belongs to the UPF0176 family
YE1620	COG0628	permease
YE1625	COG0418	dihydroorotase activity
YE1626	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
YE1627	COG1530	ribonuclease E activity
YE1628	COG0564	pseudouridine synthase activity
YE1629	COG0424	maF-like protein
YE1630	COG1399	metal-binding, possibly nucleic acid-binding protein
YE1631	COG0333	Belongs to the bacterial ribosomal protein bL32 family
YE1632	COG0416	fatty acid biosynthetic process
YE1633	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
YE1634	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
YE1635	COG1028	Short-chain dehydrogenase reductase Sdr
YE1637	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
YE1638	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
YE1639	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
YE1640	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
YE1641	COG0470	DNA polymerase III
YE1642	COG0084	hydrolase, TatD family'
YE1643	COG1263	PTS System
YE1643	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
YE1658	COG1487	ribonuclease activity
YE1679	COG4695	Portal protein
YE1692	COG4974	Belongs to the 'phage' integrase family
YE1698	COG0641	radical SAM
YE1700	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
YE1701	COG0537	adenosine 5'-monophosphoramidase activity
YE1702	COG5633	Lipoprotein
YE1703	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
YE1705	COG1472	Belongs to the glycosyl hydrolase 3 family
YE1706	COG3150	esterase
YE1707	COG1252	NADH dehydrogenase
YE1708	COG3134	Outer membrane lipoprotein
YE1709	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
YE1710	COG4591	ABC-type transport system involved in lipoprotein release permease component
YE1712	COG4591	ABC-type transport system involved in lipoprotein release permease component
YE1713	COG1940	carbohydrate kinase activity
YE1716	COG2850	peptidyl-arginine hydroxylation
YE1718	COG0745	RESPONSE REGULATOR receiver
YE1720	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
YE1721	COG2915	High frequency lysogenization protein hflD homolog
YE1722	COG0482	sulfurtransferase activity
YE1724	COG1187	pseudouridine synthase activity
YE1725	COG0538	isocitrate dehydrogenase activity
YE1731	COG0840	transmembrane signaling receptor activity
YE1738	COG0702	epimerase
YE1739	COG1733	regulation of RNA biosynthetic process
YE1744	COG3755	Protein conserved in bacteria
YE1746	COG2203	Gaf domain
YE1746	COG5001	Diguanylate cyclase
YE1746	COG4251	negative regulation of phosphorylation
YE1746	COG3706	GGDEF domain
YE1748	COG1132	(ABC) transporter
YE1753	COG2207	Transcriptional regulator
YE1761	COG1113	amino acid transport
YE1766	COG1496	oxidoreductase activity
YE1767	COG0768	penicillin binding
YE1768	COG2226	methyltransferase
YE1770	COG5002	protein histidine kinase activity
YE1770	COG5001	Diguanylate cyclase
YE1770	COG3447	MASE1 domain protein
YE1772	COG1971	Probably functions as a manganese efflux pump
YE1773	COG4811	Protein of unknown function (DUF986)
YE1775	COG3716	PTS system mannose fructose sorbose family IID component
YE1776	COG3715	PTS system
YE1777	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
YE1777	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
YE1778	COG1253	flavin adenine dinucleotide binding
YE1779	COG1760	l-serine dehydratase
YE1780	COG0494	nUDIX hydrolase
YE1782	COG3140	Belongs to the UPF0181 family
YE1784	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
YE1785	COG0513	Belongs to the DEAD box helicase family
YE1786	COG3141	response to X-ray
YE1787	COG3097	Belongs to the UPF0267 family
YE1789	COG1770	oligopeptidase
YE1790	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
YE1795	COG1528	Iron-storage protein
YE1796	COG2372	response to copper ion
YE1797	COG1276	copper resistance
YE1805	COG4695	Portal protein
YE1810	COG2963	transposase activity
YE1811	COG2801	Transposase and inactivated derivatives
YE1821	COG2801	Transposase and inactivated derivatives
YE1822	COG2963	transposase activity
YE1823	COG2801	Transposase and inactivated derivatives
YE1829	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
YE1830	COG0322	excinuclease ABC activity
YE1831	COG2197	response regulator
YE1833	COG3136	membrane protein required for alginate biosynthesis
YE1840	COG3772	lysozyme
YE1842	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
YE1843	COG1187	pseudouridine synthase activity
YE1847	COG0668	transmembrane transport
YE1848	COG0625	glutathione transferase activity
YE1855	COG4251	negative regulation of phosphorylation
YE1855	COG3706	GGDEF domain
YE1855	COG5001	Diguanylate cyclase
YE1855	COG2203	Gaf domain
YE1862	COG2814	Major facilitator Superfamily
YE1864	COG3008	intermembrane lipid transfer
YE1865	COG2995	paraquat-inducible protein a
YE1866	COG1956	GAF domain-containing protein
YE1868	COG0793	Belongs to the peptidase S41A family
YE1869	COG0501	Belongs to the peptidase M48B family
YE1875	COG2814	Major facilitator Superfamily
YE1876	COG0823	Involved in the tonB-independent uptake of proteins
YE1878	COG3023	N-Acetylmuramoyl-L-alanine amidase
YE1879	COG1823	symporter activity
YE1880	COG1988	membrane-bound metal-dependent
YE1881	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
YE1882	COG1653	transport
YE1883	COG3842	ATPase activity
YE1884	COG0395	ABC-type sugar transport system, permease component
YE1885	COG1175	transmembrane transport
YE1887	COG1028	Short-chain dehydrogenase reductase Sdr
YE1888	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
YE1889	COG1917	Cupin 2, conserved barrel domain protein
YE1890	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
YE1892	COG0583	DNA-binding transcription factor activity
YE1893	COG0427	acetyl-CoA hydrolase
YE1894	COG1024	Enoyl-CoA hydratase
YE1894A	COG1703	isobutyryl-CoA mutase activity
YE1895	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
YE1895	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
YE1896	COG3001	Fructosamine kinase
YE1897	COG1108	ABC-type Mn2 Zn2 transport systems permease components
YE1898	COG1108	ABC-type Mn2 Zn2 transport systems permease components
YE1899	COG1121	(ABC) transporter
YE1900	COG0803	Belongs to the bacterial solute-binding protein 9 family
YE1909	COG1811	Na channel or pump
YE1910	COG4249	Peptidase C14 caspase catalytic subunit p20
YE1912	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
YE1913	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
YE1914	COG0291	Belongs to the bacterial ribosomal protein bL35 family
YE1915	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
YE1916	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
YE1918	COG0776	regulation of translation
YE1919	COG2963	transposase activity
YE1928	COG3077	Addiction module antitoxin, RelB DinJ family
YE1929	COG3041	Addiction module toxin RelE StbE family
YE1933	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
YE1933	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
YE1933	COG0506	proline dehydrogenase activity
YE1937	COG3157	Type VI secretion system effector, Hcp
YE1938	COG0672	)-iron permease
YE1939	COG2822	iron ion transport
YE1941	COG0655	NAD(P)H dehydrogenase (quinone) activity
YE1943	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
YE1944	COG2233	PERMEase
YE1945	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
YE1946	COG0778	Nitroreductase
YE1947	COG2267	carboxylic ester hydrolase activity
YE1948	COG0251	oxidation-reduction process
YE1949	COG1335	isochorismatase
YE1950	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
YE1951	COG1309	transcriptional regulator
YE1952	COG1113	amino acid transport
YE1959	COG2226	methyltransferase
YE1962	COG0366	Alpha amylase catalytic
YE1966	COG0671	phosphoesterase, PA-phosphatase related
YE1967	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
YE1968	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
YE1970	COG1396	sequence-specific DNA binding
YE1971	COG3135	benzoate transporter
YE1973	COG0284	orotidine-5'-phosphate decarboxylase activity
YE1974	COG0023	Translation Initiation Factor
YE1976	COG0235	Class ii aldolase
YE1978	COG1349	DNA-binding transcription factor activity
YE1979	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
YE1980	COG2879	small protein
YE1981	COG1966	Carbon starvation protein
YE1982	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
YE1983	COG0243	molybdopterin cofactor binding
YE1987	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
YE1989	COG4659	FMN binding
YE1990	COG4658	electron transport chain
YE1991	COG2207	Transcriptional regulator
YE1991	COG3708	Transcriptional regulator
YE1992	COG4656	Part of a membrane complex involved in electron transport
YE1994	COG4657	Part of a membrane complex involved in electron transport
YE1997	COG2759	Belongs to the formate--tetrahydrofolate ligase family
YE2001	COG2160	L-arabinose isomerase activity
YE2003	COG1879	ABC-type sugar transport system periplasmic component
YE2004	COG1129	ABC transporter
YE2005	COG1172	Belongs to the binding-protein-dependent transport system permease family
YE2007	COG0673	inositol 2-dehydrogenase activity
YE2008	COG0385	Bile acid
YE2009	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
YE2010	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
YE2011	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
YE2011	COG1263	PTS System
YE2012	COG1609	Transcriptional regulator
YE2014	COG5339	Protein conserved in bacteria
YE2016	COG0114	fumarate hydratase activity
YE2021	COG2814	Major facilitator Superfamily
YE2022	COG0583	DNA-binding transcription factor activity
YE2023	COG1940	carbohydrate kinase activity
YE2024	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
YE2027	COG1742	UPF0060 membrane protein
YE2028	COG4221	oxidoreductase activity
YE2029	COG0477	Major facilitator Superfamily
YE2038	COG0625	glutathione transferase activity
YE2040	COG1522	sequence-specific DNA binding
YE2047	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
YE2051	COG0583	DNA-binding transcription factor activity
YE2052	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
YE2054	COG0483	inositol monophosphate 1-phosphatase activity
YE2055	COG2271	Major facilitator Superfamily
YE2060	COG0028	Belongs to the TPP enzyme family
YE2061	COG0440	acetolactate synthase activity
YE2062	COG1011	Hydrolase
YE2066	COG0738	Major facilitator superfamily
YE2067	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
YE2069	COG1028	Short-chain dehydrogenase reductase Sdr
YE2070	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
YE2074	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
YE2075	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
YE2076	COG0589	response to stress
YE2077	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
YE2078	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
YE2081	COG0531	amino acid
YE2083	COG0745	RESPONSE REGULATOR receiver
YE2084	COG2205	protein histidine kinase activity
YE2085	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
YE2087	COG3591	Belongs to the peptidase S1B family
YE2090	COG1643	Atp-dependent helicase
YE2092	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
YE2095	COG3784	Protein of unknown function (DUF1318)
YE2097	COG2911	Protein conserved in bacteria
YE2098	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
YE2099	COG3042	response to heat
YE2100	COG1285	pathogenesis
YE2102	COG1013	pyruvate-flavodoxin oxidoreductase activity
YE2102	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
YE2102	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
YE2102	COG0674	pyruvate-flavodoxin oxidoreductase activity
YE2103	COG2723	6-phospho-beta-galactosidase activity
YE2104	COG2190	(PTS) system
YE2104	COG1263	PTS System
YE2104	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
YE2105	COG3711	transcriptional antiterminator
YE2106	COG0037	tRNA processing
YE2107	COG0598	Magnesium transport protein CorA
YE2110	COG4166	transmembrane transport
YE2111	COG2866	Carboxypeptidase
YE2112	COG4948	Mandelate Racemase Muconate Lactonizing
YE2113	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
YE2115	COG5642	Protein of unknown function (DUF2384)
YE2116	COG5654	RES domain protein
YE2117	COG3768	UPF0283 membrane protein
YE2118	COG3106	COG3106 Predicted ATPase
YE2119	COG1983	PspC domain protein
YE2121	COG1842	Phage shock protein A
YE2122	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
YE2125	COG4166	transmembrane transport
YE2126	COG4168	peptide transport system, permease
YE2127	COG4171	peptide transport system, permease
YE2129	COG4172	Belongs to the ABC transporter superfamily
YE2131	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
YE2131	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
YE2133	COG3104	oligopeptide transport
YE2137	COG0625	glutathione transferase activity
YE2139	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
YE2140	COG0259	pyridoxamine-phosphate oxidase activity
YE2141	COG3895	Periplasmic Protein
YE2142	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
YE2143	COG3133	Outer membrane lipoprotein
YE2144	COG1846	Transcriptional regulator
YE2146	COG1566	PFAM secretion protein HlyD family protein
YE2147	COG1289	transmembrane transporter activity
YE2148	COG4989	oxidoreductase activity
YE2149	COG3313	Fe-S protein
YE2150	COG2194	sulfuric ester hydrolase activity
YE2151	COG1309	transcriptional regulator
YE2152	COG1902	pentaerythritol trinitrate reductase activity
YE2153	COG0346	lactoylglutathione lyase activity
YE2154	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
YE2155	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
YE2156	COG0791	NLP P60 protein
YE2158	COG1609	Transcriptional regulator
YE2159	COG0583	DNA-binding transcription factor activity
YE2160	COG2814	Major facilitator Superfamily
YE2161	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
YE2162	COG0307	riboflavin synthase, alpha
YE2163	COG0534	Mate efflux family protein
YE2166	COG1388	LysM domain
YE2166	COG1376	ErfK ybiS ycfS ynhG family protein
YE2167	COG2166	iron-sulfur cluster assembly
YE2169	COG0719	Fe-S assembly protein
YE2170	COG0396	ATPase activity
YE2171	COG0719	Fe-S assembly protein
YE2172	COG0316	Belongs to the HesB IscA family
YE2173	COG2050	protein possibly involved in aromatic compounds catabolism
YE2174	COG0277	FAD linked oxidase domain protein
YE2174	COG0247	lactate metabolic process
YE2175	COG0628	permease
YE2176	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
YE2176	COG0574	Belongs to the PEP-utilizing enzyme family
YE2177	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
YE2180	COG4771	TonB-dependent receptor
YE2181	COG3720	iron ion transport
YE2182	COG4558	Periplasmic binding protein
YE2184	COG0095	Lipoate-protein ligase
YE2185	COG0791	NLP P60 protein
YE2186	COG2076	Multidrug Resistance protein
YE2187	COG2076	Multidrug Resistance protein
YE2188	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
YE2189	COG0726	polysaccharide deacetylase
YE2190	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
YE2190	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
YE2191	COG0463	Glycosyl transferase, family 2
YE2192	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
YE2193	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
YE2194	COG0386	Belongs to the glutathione peroxidase family
YE2195	COG4139	cobalamin transport
YE2198	COG0583	DNA-binding transcription factor activity
YE2203	COG0616	signal peptide processing
YE2204	COG1028	Short-chain dehydrogenase reductase Sdr
YE2205	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
YE2206	COG1187	pseudouridine synthase activity
YE2207	COG0009	L-threonylcarbamoyladenylate synthase
YE2208	COG0613	PHP domain protein
YE2210	COG0512	Glutamine amidotransferase of anthranilate synthase
YE2212	COG0134	indole-3-glycerol-phosphate synthase activity
YE2212	COG0135	phosphoribosylanthranilate isomerase activity
YE2213	COG0133	tryptophan synthase activity
YE2214	COG0159	tryptophan synthase activity
YE2216	COG3047	cAMP biosynthetic process
YE2216A	COG0727	PFAM Uncharacterised protein family (UPF0153)
YE2220	COG2917	probably involved in intracellular septation
YE2221	COG1607	acyl-coa hydrolase
YE2222	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
YE2223	COG2350	Protein conserved in bacteria
YE2227	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
YE2228	COG3099	Belongs to the UPF0263 family
YE2230	COG0444	Belongs to the ABC transporter superfamily
YE2231	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
YE2237	COG2095	MarC family integral membrane protein
YE2238	COG1012	belongs to the aldehyde dehydrogenase family
YE2238	COG1454	alcohol dehydrogenase
YE2241	COG2916	Histone family protein nucleoid-structuring protein H-NS
YE2243	COG0745	RESPONSE REGULATOR receiver
YE2244	COG1752	Esterase of the alpha-beta hydrolase superfamily
YE2246	COG3012	SEC-C Motif Domain Protein
YE2247	COG0788	formyltetrahydrofolate deformylase activity
YE2253	COG0583	DNA-binding transcription factor activity
YE2254	COG0708	Exodeoxyribonuclease III
YE2255	COG0494	nUDIX hydrolase
YE2257	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
YE2259	COG0778	Nitroreductase
YE2260	COG0616	signal peptide processing
YE2261	COG0252	asparaginase activity
YE2262	COG1335	isochorismatase
YE2263	COG3139	Protein of unknown function (DUF1315)
YE2264	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
YE2271	COG3713	MltA-interacting MipA family protein
YE2272	COG2766	serine protein kinase
YE2273	COG2718	Belongs to the UPF0229 family
YE2276	COG0583	DNA-binding transcription factor activity
YE2278	COG2200	EAL domain
YE2278	COG2202	Pas domain
YE2278	COG2199	diguanylate cyclase activity
YE2279	COG2814	Major facilitator Superfamily
YE2280	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
YE2281	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
YE2282	COG2719	SpoVR family
YE2283	COG2186	Transcriptional regulator
YE2284	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
YE2285	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
YE2286	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
YE2308	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
YE2326	COG5484	DNA packaging
YE2326	COG3728	DNA packaging
YE2331	COG3646	Phage regulatory protein
YE2334	COG3772	lysozyme
YE2355	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
YE2364	COG0582	viral genome integration into host DNA
YE2365	COG2983	Belongs to the UPF0260 family
YE2366	COG0179	Fumarylacetoacetate (FAA) hydrolase
YE2367	COG2951	lytic endotransglycosylase activity
YE2368	COG3100	YcgL domain-containing protein
YE2371	COG0850	regulation of cytokinetic process
YE2372	COG2894	cell division
YE2373	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
YE2374	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
YE2375	COG0318	PFAM AMP-dependent synthetase and ligase
YE2376	COG3065	identical protein binding
YE2378	COG1199	ATP-dependent helicase activity
YE2379	COG0251	oxidation-reduction process
YE2380	COG2076	Multidrug Resistance protein
YE2381	COG2076	Multidrug Resistance protein
YE2382	COG0800	Aldolase
YE2383	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
YE2384	COG1737	Transcriptional regulator
YE2385	COG0469	pyruvate kinase activity
YE2386	COG1560	Kdo2-lipid A biosynthetic process
YE2387	COG0739	heme binding
YE2388	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
YE2389	COG1121	(ABC) transporter
YE2390	COG1108	ABC-type Mn2 Zn2 transport systems permease components
YE2391	COG3104	oligopeptide transport
YE2392	COG2255	four-way junction helicase activity
YE2393	COG0632	four-way junction helicase activity
YE2394	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
YE2395	COG0217	transcriptional regulatory protein
YE2396	COG0494	nUDIX hydrolase
YE2397	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
YE2398	COG1335	isochorismatase
YE2399	COG1801	Protein of unknown function DUF72
YE2400	COG3788	relative of glutathione S-transferase, MAPEG superfamily
YE2401	COG2226	methyltransferase
YE2402	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
YE2403	COG3142	Participates in the control of copper homeostasis
YE2404	COG3102	Protein conserved in bacteria
YE2406	COG0018	arginyl-trna synthetase
YE2409	COG0728	peptidoglycan biosynthetic process
YE2410	COG0673	inositol 2-dehydrogenase activity
YE2412	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
YE2418	COG0477	Major facilitator Superfamily
YE2420	COG3381	protein complex oligomerization
YE2421	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
YE2422	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
YE2425	COG3706	GGDEF domain
YE2426	COG0659	secondary active sulfate transmembrane transporter activity
YE2427	COG2877	3-deoxy-8-phosphooctulonate synthase activity
YE2430	COG2890	protein-(glutamine-N5) methyltransferase activity
YE2431	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
YE2432	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
YE2433	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
YE2435	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
YE2437	COG0193	aminoacyl-tRNA hydrolase activity
YE2439	COG0012	GTP binding
YE2442	COG2979	Protein of unknown function (DUF533)
YE2448	COG1349	DNA-binding transcription factor activity
YE2449	COG2222	sugar isomerase
YE2451	COG4942	peptidase
YE2457	COG3443	Belongs to the bacterial solute-binding protein 9 family
YE2459	COG0402	S-adenosylhomocysteine deaminase activity
YE2461	COG1228	amidohydrolase
YE2465	COG2988	succinylglutamate desuccinylase activity
YE2466	COG3724	N-succinylarginine dihydrolase activity
YE2468	COG3138	arginine N-succinyltransferase
YE2469	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
YE2470	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
YE2471	COG1271	oxidase subunit
YE2472	COG1294	oxidase, subunit
YE2473	COG3850	Histidine kinase
YE2474	COG0583	DNA-binding transcription factor activity
YE2475	COG2814	Major facilitator Superfamily
YE2477	COG0387	Pfam Sodium calcium exchanger
YE2478	COG1702	phosphate starvation-inducible protein PhoH
YE2481	COG3658	cytochrome
YE2482	COG1215	transferase activity, transferring glycosyl groups
YE2483	COG0726	polysaccharide deacetylase
YE2483	COG1649	PFAM Uncharacterised BCR, COG1649
YE2484	COG0457	Tetratricopeptide repeat
YE2485	COG0006	proline dipeptidase activity
YE2486	COG4114	ferric iron reductase
YE2487	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
YE2492	COG0577	efflux transmembrane transporter activity
YE2492	COG1136	(ABC) transporter
YE2494	COG0577	efflux transmembrane transporter activity
YE2494	COG1136	(ABC) transporter
YE2497	COG0672	)-iron permease
YE2500	COG2066	Belongs to the glutaminase family
YE2501	COG3622	Belongs to the hyi family
YE2502	COG0235	Class ii aldolase
YE2503	COG3395	kinase activity
YE2504	COG1349	DNA-binding transcription factor activity
YE2505	COG3290	protein histidine kinase activity
YE2506	COG4565	transcriptional regulatory protein
YE2507	COG3493	citrate carrier protein
YE2512	COG2223	nitrite transmembrane transporter activity
YE2513	COG0561	phosphatase activity
YE2514	COG1126	abc transporter atp-binding protein
YE2515	COG0765	amino acid transport
YE2516	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
YE2517	COG2515	1-aminocyclopropane-1-carboxylate deaminase
YE2519	COG1191	sigma factor activity
YE2528	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
YE2529	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
YE2536	COG1677	Flagellar hook-basal body complex protein FliE
YE2539	COG1317	bacterial-type flagellum organization
YE2543	COG1580	Controls the rotational direction of flagella during chemotaxis
YE2547	COG1338	Plays a role in the flagellum-specific transport system
YE2551	COG1256	bacterial-type flagellum assembly
YE2558	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
YE2559	COG1558	bacterial-type flagellum-dependent cell motility
YE2560	COG1815	bacterial-type flagellum-dependent cell motility
YE2562	COG2747	anti-sigma28 factor FlgM
YE2563	COG3418	PFAM FlgN family protein
YE2566	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
YE2567	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
YE2568	COG4935	Belongs to the peptidase S8 family
YE2568	COG1404	Belongs to the peptidase S8 family
YE2569	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
YE2570	COG0745	RESPONSE REGULATOR receiver
YE2572	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
YE2573	COG0840	transmembrane signaling receptor activity
YE2575	COG0840	transmembrane signaling receptor activity
YE2576	COG0835	chemotaxis
YE2577	COG0643	Histidine kinase
YE2577	COG2198	Histidine kinase
YE2578	COG1360	Flagellar Motor Protein
YE2583	COG0589	response to stress
YE2584	COG2130	NADP-dependent
YE2586	COG1285	pathogenesis
YE2588	COG0840	transmembrane signaling receptor activity
YE2591	COG1609	Transcriptional regulator
YE2592	COG3250	beta-galactosidase activity
YE2595	COG0604	alcohol dehydrogenase
YE2595	COG3321	synthase
YE2595	COG1028	Short-chain dehydrogenase reductase Sdr
YE2601	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
YE2602	COG3121	Chaperone
YE2603	COG1070	Carbohydrate kinase
YE2604	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
YE2606	COG1172	Belongs to the binding-protein-dependent transport system permease family
YE2607	COG1172	Belongs to the binding-protein-dependent transport system permease family
YE2608	COG1129	ABC transporter
YE2610	COG3228	Belongs to the MtfA family
YE2612	COG1169	isochorismate synthase
YE2613	COG2814	Major facilitator Superfamily
YE2614	COG1132	(ABC) transporter
YE2615	COG1132	(ABC) transporter
YE2615	COG2375	cellular response to nickel ion
YE2617	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
YE2617	COG3433	isochorismatase activity
YE2617	COG2226	methyltransferase
YE2621	COG1021	2,3-dihydroxybenzoate-AMP ligase
YE2622	COG4771	TonB-dependent receptor
YE2629	COG2801	Transposase and inactivated derivatives
YE2630	COG2963	transposase activity
YE2632	COG1204	response to ionizing radiation
YE2637	COG3122	Protein conserved in bacteria
YE2639	COG2814	Major facilitator Superfamily
YE2644	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
YE2647	COG0471	metal ion transport
YE2650	COG3051	citrate lyase alpha subunit
YE2651	COG2301	Belongs to the HpcH HpaI aldolase family
YE2652	COG3052	prosthetic group binding
YE2653	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
YE2654	COG3290	protein histidine kinase activity
YE2655	COG4565	transcriptional regulatory protein
YE2658	COG2271	Major facilitator Superfamily
YE2659	COG1840	ABC-type Fe3 transport system, periplasmic component
YE2661	COG3842	ATPase activity
YE2663	COG2205	protein histidine kinase activity
YE2663	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
YE2668	COG3121	Chaperone
YE2673	COG0784	Response regulator, receiver
YE2673	COG0835	chemotaxis
YE2675	COG1349	DNA-binding transcription factor activity
YE2676	COG0561	phosphatase activity
YE2677	COG0352	thiamine-phosphate diphosphorylase activity
YE2679	COG0534	Mate efflux family protein
YE2680	COG0137	argininosuccinate synthase activity
YE2693	COG3188	usher protein
YE2694	COG3121	Chaperone
YE2707	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
YE2711	COG1492	cobalamin metabolic process
YE2722	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
YE2724	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
YE2739	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
YE2741	COG1012	belongs to the aldehyde dehydrogenase family
YE2743	COG4656	Part of a membrane complex involved in electron transport
YE2747	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
YE2748	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
YE2748	COG1648	precorrin-2 dehydrogenase activity
YE2749	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
YE2752	COG1129	ABC transporter
YE2753	COG1172	Belongs to the binding-protein-dependent transport system permease family
YE2755	COG2926	Belongs to the UPF0265 family
YE2756	COG1289	transmembrane transporter activity
YE2757	COG1022	Amp-dependent synthetase and ligase
YE2757	COG3320	Male sterility
YE2758	COG2925	Exonuclease
YE2759	COG0531	amino acid
YE2761	COG0371	Dehydrogenase
YE2762	COG1129	ABC transporter
YE2763	COG1172	Belongs to the binding-protein-dependent transport system permease family
YE2764	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
YE2765	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
YE2767	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
YE2768	COG0131	Imidazoleglycerol-phosphate dehydratase
YE2768	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
YE2770	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
YE2771	COG0107	imidazoleglycerol-phosphate synthase activity
YE2772	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
YE2772	COG0140	phosphoribosyl-ATP diphosphatase activity
YE2773	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
YE2774	COG3385	transposase activity
YE2777	COG1210	Utp--glucose-1-phosphate uridylyltransferase
YE2778	COG1210	Utp--glucose-1-phosphate uridylyltransferase
YE2779	COG1253	flavin adenine dinucleotide binding
YE2780	COG3069	C4-dicarboxylate transmembrane transporter activity
YE2781	COG2982	Protein involved in outer membrane biogenesis
YE2782	COG0717	Belongs to the dCTP deaminase family
YE2783	COG0572	uridine kinase
YE2784	COG0489	protein tyrosine kinase activity
YE2785	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
YE2785	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
YE2789	COG2814	Major facilitator Superfamily
YE2790	COG1380	Effector of murein hydrolase LrgA
YE2791	COG1346	cytolysis
YE2794	COG0281	malic enzyme
YE2795	COG2949	membrane
YE2796	COG0298	carbon dioxide binding
YE2797	COG0375	protein maturation
YE2798	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
YE2799	COG0651	ATP synthesis coupled electron transport
YE2800	COG0650	Formate hydrogenlyase subunit 4
YE2801	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
YE2802	COG4237	Hydrogenase 4 membrane
YE2803	COG0651	ATP synthesis coupled electron transport
YE2804	COG3261	NADH dehydrogenase
YE2804	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
YE2805	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
YE2806	COG3260	NADH ubiquinone oxidoreductase 20
YE2808	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
YE2809	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
YE2810	COG3383	formate dehydrogenase (NAD+) activity
YE2811	COG3604	Transcriptional regulator
YE2812	COG2116	formate transmembrane transporter activity
YE2816	COG1609	Transcriptional regulator
YE2817	COG2311	Membrane
YE2818	COG0302	gtp cyclohydrolase
YE2819	COG0477	Major facilitator Superfamily
YE2820	COG0583	DNA-binding transcription factor activity
YE2825	COG1136	(ABC) transporter
YE2825	COG0577	efflux transmembrane transporter activity
YE2828	COG0303	'Molybdopterin
YE2829	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
YE2830	COG3397	chitin binding
YE2831	COG0488	(ABC) transporter
YE2835	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
YE2839	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
YE2842	COG4106	trans-aconitate 2-methyltransferase activity
YE2843	COG0783	Belongs to the Dps family
YE2844	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
YE2845	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
YE2846	COG0765	amino acid transport
YE2847	COG1126	abc transporter atp-binding protein
YE2849	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
YE2853	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
YE2854	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
YE2858	COG0697	spore germination
YE2859	COG0583	DNA-binding transcription factor activity
YE2862	COG1174	glycine betaine transport
YE2863	COG1125	glycine betaine transport
YE2864	COG1174	glycine betaine transport
YE2865	COG1732	Glycine betaine
YE2868	COG2897	thiosulfate sulfurtransferase activity
YE2870	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
YE2874	COG4807	Protein conserved in bacteria
YE2877	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
YE2879	COG2261	transglycosylase associated protein
YE2883	COG0277	FAD linked oxidase domain protein
YE2884	COG1686	Belongs to the peptidase S11 family
YE2886	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
YE2889	COG0513	Belongs to the DEAD box helicase family
YE2890	COG1309	transcriptional regulator
YE2891	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
YE2892	COG1131	(ABC) transporter
YE2893	COG0842	Transport permease protein
YE2894	COG0842	Transport permease protein
YE2895	COG0670	Belongs to the BI1 family
YE2896	COG0314	molybdopterin synthase activity
YE2897	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
YE2898	COG0315	cyclic pyranopterin monophosphate synthase activity
YE2899	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
YE2900	COG0391	Required for morphogenesis under gluconeogenic growth conditions
YE2901	COG4628	conserved protein (DUF2132)
YE2902	COG0556	nucleotide-excision repair
YE2905	COG2226	methyltransferase
YE2906	COG0156	8-amino-7-oxononanoate synthase activity
YE2907	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
YE2909	COG2706	6-phosphogluconolactonase activity
YE2910	COG0561	phosphatase activity
YE2912	COG4149	molybdate abc transporter
YE2913	COG0725	ABC transporter, periplasmic molybdate-binding protein
YE2914	COG3585	molybdate ion transport
YE2914	COG2005	Transcriptional regulator
YE2915	COG1119	ATPase activity
YE2917	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
YE2918	COG1085	galactose-1-phosphate uridylyltransferase
YE2919	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
YE2920	COG2017	converts alpha-aldose to the beta-anomer
YE2924	COG0588	phosphoglycerate mutase activity
YE2925	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
YE2926	COG1230	cation diffusion facilitator family transporter
YE2928	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
YE2930	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
YE2931	COG2885	chlorophyll binding
YE2932	COG0823	Involved in the tonB-independent uptake of proteins
YE2933	COG3064	Membrane
YE2933	COG3064	Membrane
YE2934	COG0848	biopolymer transport protein
YE2935	COG0811	peptide transport
YE2936	COG0824	Thioesterase
YE2937	COG3790	cyd operon protein YbgE
YE2938	COG1294	oxidase, subunit
YE2939	COG1271	oxidase subunit
YE2940	COG0737	Belongs to the 5'-nucleotidase family
YE2941	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
YE2942	COG0045	succinate-CoA ligase (ADP-forming) activity
YE2943	COG0508	dehydrogenase complex catalyzes the overall conversion of
YE2944	COG0567	Dehydrogenase, E1 component
YE2946	COG1053	succinate dehydrogenase
YE2947	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
YE2948	COG2009	succinate dehydrogenase
YE2950	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
YE2953	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
YE2954	COG1984	allophanate hydrolase subunit 2
YE2955	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
YE2955A	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
YE2956	COG5212	phosphodiesterase
YE2958	COG3272	Protein of unknown function (DUF1722)
YE2960	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
YE2961	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
YE2962	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
YE2963	COG2205	protein histidine kinase activity
YE2964	COG0745	RESPONSE REGULATOR receiver
YE2967	COG0033	Phosphoglucomutase
YE2968	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
YE2969	COG0596	Alpha beta hydrolase
YE2971	COG0840	transmembrane signaling receptor activity
YE2973	COG0735	belongs to the Fur family
YE2977	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
YE2978	COG1263	PTS System
YE2978	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
YE2978	COG2190	(PTS) system
YE2979	COG0363	glucosamine-6-phosphate deaminase activity
YE2980	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
YE2981	COG1846	Transcriptional regulator
YE2981	COG1940	carbohydrate kinase activity
YE2982	COG0647	UMP catabolic process
YE2983	COG0367	asparagine synthase
YE2984	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
YE2985	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
YE2986	COG1702	phosphate starvation-inducible protein PhoH
YE2987	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
YE2988	COG4535	Mg2 and Co2 transporter CorC
YE2989	COG0815	Transfers the fatty acyl group on membrane lipoproteins
YE2992	COG0765	amino acid transport
YE2993	COG0765	amino acid transport
YE2994	COG1126	abc transporter atp-binding protein
YE2995	COG2888	peptidyl-tyrosine sulfation
YE2996	COG0495	leucyl-tRNA aminoacylation
YE2997	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
YE2998	COG1466	dna polymerase III delta subunit
YE2999	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
YE3000	COG0799	negative regulation of ribosome biogenesis
YE3001	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
YE3002	COG0768	penicillin binding
YE3003	COG0772	Belongs to the SEDS family
YE3004	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
YE3005	COG1686	Belongs to the peptidase S11 family
YE3006	COG2921	Belongs to the UPF0250 family
YE3007	COG0321	lipoyl(octanoyl) transferase activity
YE3008	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
YE3009	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
YE3010	COG3706	GGDEF domain
YE3013	COG1278	Cold shock
YE3014	COG2197	response regulator
YE3016	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
YE3019	COG5265	(ABC) transporter
YE3021	COG2986	histidine ammonia-lyase
YE3022	COG2850	peptidyl-arginine hydroxylation
YE3025	COG5002	protein histidine kinase activity
YE3031	COG0656	L-ascorbic acid biosynthetic process
YE3034	COG1902	pentaerythritol trinitrate reductase activity
YE3045	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
YE3046	COG2501	S4 domain
YE3048	COG0215	cysteine-tRNA ligase activity
YE3049	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
YE3050	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
YE3051	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
YE3052	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
YE3053	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
YE3054	COG4181	ATPase activity
YE3055	COG2755	lipolytic protein G-D-S-L family
YE3056	COG0300	oxidoreductase activity
YE3057	COG3118	belongs to the thioredoxin family
YE3058	COG0330	HflC and HflK could
YE3059	COG1585	Membrane protein implicated in regulation of membrane protease activity
YE3060	COG0789	Transcriptional regulator
YE3061	COG2217	Heavy metal translocating P-type atpase
YE3062	COG3735	TraB family
YE3063	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
YE3066	COG0737	Belongs to the 5'-nucleotidase family
YE3067	COG2223	nitrite transmembrane transporter activity
YE3068	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
YE3068	COG4651	solute:proton antiporter activity
YE3069	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
YE3072	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
YE3074	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
YE3075	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
YE3076	COG0438	transferase activity, transferring glycosyl groups
YE3078	COG1216	Glycosyl transferase, family 2
YE3084	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
YE3087	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
YE3088	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
YE3089	COG0563	adenylate kinase activity
YE3090	COG0326	Molecular chaperone. Has ATPase activity
YE3091	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
YE3092	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
YE3094	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
YE3094A	COG2832	Protein of unknown function (DUF454)
YE3097	COG1196	nuclear chromosome segregation
YE3097	COG3264	Mechanosensitive ion channel
YE3098	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
YE3099	COG1309	transcriptional regulator
YE3100	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
YE3101	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
YE3103	COG3457	Alanine racemase
YE3104	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
YE3107	COG0254	rRNA binding
YE3108	COG0257	Belongs to the bacterial ribosomal protein bL36 family
YE3109	COG0803	Belongs to the bacterial solute-binding protein 9 family
YE3110	COG1108	ABC-type Mn2 Zn2 transport systems permease components
YE3116	COG3695	enzyme binding
YE3117	COG3126	Type III secretion system lipoprotein chaperone (YscW)
YE3118	COG1946	Acyl-CoA thioesterase
YE3119	COG0004	ammonium transporteR
YE3120	COG0347	Belongs to the P(II) protein family
YE3121	COG1132	(ABC) transporter
YE3122	COG1132	(ABC) transporter
YE3123	COG1522	sequence-specific DNA binding
YE3125	COG0561	phosphatase activity
YE3126	COG4533	DNA binding
YE3127	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
YE3128	COG0824	Thioesterase
YE3129	COG1555	photosystem II stabilization
YE3130	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
YE3131	COG0776	regulation of translation
YE3132	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
YE3133	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
YE3134	COG0740	serine-type endopeptidase activity
YE3135	COG0544	peptidyl-prolyl cis-trans isomerase activity
YE3137	COG0271	Belongs to the BolA IbaG family
YE3138	COG3056	Lipoprotein
YE3139	COG2223	nitrite transmembrane transporter activity
YE3141	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
YE3142	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
YE3143	COG1845	cytochrome c oxidase, subunit III
YE3144	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
YE3145	COG0109	protoheme IX farnesyltransferase activity
YE3146	COG2814	Major facilitator Superfamily
YE3147	COG1666	GTP binding
YE3149	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
YE3151	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
YE3151	COG0301	tRNA thio-modification
YE3153	COG1722	exodeoxyribonuclease VII activity
YE3154	COG0142	geranyltranstransferase activity
YE3155	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
YE3157	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
YE3158	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
YE3159	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
YE3160	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
YE3161	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
YE3161	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
YE3162	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
YE3163	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
YE3164	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
YE3165	COG1862	Preprotein translocase
YE3166	COG0343	queuine tRNA-ribosyltransferase activity
YE3172	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
YE3173	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
YE3174	COG0450	alkyl hydroperoxide reductase
YE3177	COG0366	Alpha amylase catalytic
YE3181	COG5002	protein histidine kinase activity
YE3182	COG0745	RESPONSE REGULATOR receiver
YE3183	COG0420	3'-5' exonuclease activity
YE3184	COG0419	ATPase involved in DNA repair
YE3185	COG1940	carbohydrate kinase activity
YE3186	COG2974	May be involved in recombination
YE3187	COG3123	guanosine phosphorylase activity
YE3188	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
YE3193	COG2226	methyltransferase
YE3196	COG3459	Glycosyltransferase 36 associated
YE3198	COG1486	melibiose metabolic process
YE3200	COG2188	Transcriptional regulator
YE3201	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
YE3202	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
YE3204	COG1073	alpha beta
YE3205	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
YE3206	COG2195	Cleaves the N-terminal amino acid of tripeptides
YE3207	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
YE3210	COG2964	Protein conserved in bacteria
YE3211	COG1181	Belongs to the D-alanine--D-alanine ligase family
YE3213	COG2991	Protein conserved in bacteria
YE3214	COG1477	protein flavinylation
YE3215	COG2871	sodium ion transport
YE3216	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
YE3217	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
YE3218	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
YE3219	COG1805	sodium ion transport
YE3220	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
YE3221	COG3034	peptidoglycan biosynthetic process
YE3222	COG0121	glutamine amidotransferase
YE3223	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
YE3224	COG1960	acyl-CoA dehydrogenase activity
YE3225	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
YE3227	COG2831	hemolysin activation secretion protein
YE3228	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
YE3230	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
YE3231	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
YE3232	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
YE3233	COG0235	Class ii aldolase
YE3234	COG0436	Aminotransferase
YE3237	COG2814	Major facilitator Superfamily
YE3238	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
YE3240	COG1846	Transcriptional regulator
YE3241	COG1538	Outer membrane efflux protein
YE3242	COG1566	PFAM secretion protein HlyD family protein
YE3243	COG2814	Major facilitator Superfamily
YE3244	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
YE3245	COG3118	belongs to the thioredoxin family
YE3246	COG3148	PFAM DTW domain containing protein
YE3247	COG0045	succinate-CoA ligase (ADP-forming) activity
YE3247	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
YE3247	COG1042	CoA-binding domain protein
YE3248	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
YE3249	COG2963	transposase activity
YE3250	COG2801	Transposase and inactivated derivatives
YE3251	COG5544	Lipoprotein
YE3252	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
YE3254	COG2011	ABC-type metal ion transport system permease component
YE3255	COG1464	Belongs to the NlpA lipoprotein family
YE3257	COG1720	tRNA m6t6A37 methyltransferase activity
YE3258	COG0442	prolyl-tRNA aminoacylation
YE3259	COG3015	lipoprotein NlpE involved in copper resistance
YE3261	COG4681	YaeQ
YE3263	COG4568	rho-dependent transcription termination
YE3266	COG0346	lactoylglutathione lyase activity
YE3267	COG1982	Orn Lys Arg decarboxylase major
YE3268	COG0825	malonyl-CoA metabolic process
YE3269	COG0587	DNA-directed DNA polymerase activity
YE3270	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
YE3272	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
YE3273	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
YE3274	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
YE3275	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
YE3277	COG0750	zinc metalloprotease
YE3278	COG0575	Belongs to the CDS family
YE3280	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
YE3281	COG0233	cytoplasmic translational termination
YE3282	COG0528	UMP kinase activity
YE3283	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
YE3284	COG0052	Belongs to the universal ribosomal protein uS2 family
YE3286	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
YE3287	COG2171	N-acyltransferase activity
YE3290	COG0564	pseudouridine synthase activity
YE3291	COG3098	single-species biofilm formation
YE3295	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
YE3295	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
YE3296	COG1611	Belongs to the LOG family
YE3297	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
YE3298	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
YE3299	COG2363	Small membrane protein
YE3300	COG0583	DNA-binding transcription factor activity
YE3303	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
YE3304	COG2166	iron-sulfur cluster assembly
YE3305	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
YE3306	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
YE3307	COG0860	N-Acetylmuramoyl-L-alanine amidase
YE3308	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
YE3308	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
YE3309	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
YE3310	COG1074	ATP-dependent DNA helicase activity
YE3311	COG1025	Belongs to the peptidase M16 family
YE3312	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
YE3316	COG2165	general secretion pathway protein
YE3317	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
YE3318	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
YE3320	COG1051	belongs to the nudix hydrolase family
YE3322	COG3066	DNA modification
YE3323	COG0861	Integral membrane protein TerC family
YE3324	COG0667	Aldo Keto reductase
YE3326	COG0477	Major facilitator Superfamily
YE3327	COG0318	PFAM AMP-dependent synthetase and ligase
YE3327	COG0204	Acyl-transferase
YE3331	COG1609	Transcriptional regulator
YE3333	COG0583	DNA-binding transcription factor activity
YE3334	COG2814	Major facilitator Superfamily
YE3338	COG0840	transmembrane signaling receptor activity
YE3341	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
YE3346	COG2165	general secretion pathway protein
YE3348	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
YE3352	COG0288	reversible hydration of carbon dioxide
YE3353	COG1733	regulation of RNA biosynthetic process
YE3354	COG1028	Short-chain dehydrogenase reductase Sdr
YE3356	COG0484	heat shock protein binding
YE3357	COG1609	Transcriptional regulator
YE3358	COG2271	Major facilitator Superfamily
YE3361	COG1522	sequence-specific DNA binding
YE3362	COG3706	GGDEF domain
YE3363	COG4319	ketosteroid isomerase
YE3364	COG1393	Belongs to the ArsC family
YE3365	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
YE3373	COG4974	Belongs to the 'phage' integrase family
YE3374	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
YE3378	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
YE3379	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
YE3380	COG4974	Belongs to the 'phage' integrase family
YE3381	COG0716	FMN binding
YE3382	COG4452	Inner membrane protein CreD
YE3383	COG2205	protein histidine kinase activity
YE3384	COG0745	RESPONSE REGULATOR receiver
YE3387	COG0354	folic acid binding
YE3388	COG1272	protein, Hemolysin III
YE3391	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
YE3391	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
YE3392	COG0509	glycine decarboxylation via glycine cleavage system
YE3393	COG0404	The glycine cleavage system catalyzes the degradation of glycine
YE3394	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
YE3395	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
YE3396	COG0006	proline dipeptidase activity
YE3397	COG3079	Belongs to the UPF0149 family
YE3398	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
YE3399	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
YE3400	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
YE3401	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
YE3402	COG0583	DNA-binding transcription factor activity
YE3405	COG1279	arginine transmembrane transporter activity
YE3413	COG0191	fructose-bisphosphate aldolase activity
YE3414	COG0126	phosphoglycerate kinase activity
YE3415	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
YE3416	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
YE3417	COG0501	Belongs to the peptidase M48B family
YE3419	COG1166	arginine decarboxylase activity
YE3421	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
YE3423	COG0640	Transcriptional regulator
YE3424	COG3091	SprT-like family
YE3425	COG2356	endonuclease I
YE3426	COG1385	rRNA (uridine-N3-)-methyltransferase activity
YE3427	COG0189	ligase activity
YE3428	COG1678	Uncharacterized ACR, COG1678
YE3429	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
YE3430	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
YE3432	COG2805	Type II/IV secretion system protein
YE3433	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
YE3434	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
YE3435	COG0762	integral membrane protein
YE3436	COG1872	DUF167
YE3437	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
YE3438	COG0635	Involved in the biosynthesis of porphyrin-containing compound
YE3441	COG3171	Protein conserved in bacteria
YE3442	COG0220	tRNA (guanine-N7-)-methyltransferase activity
YE3443	COG1194	a g-specific adenine glycosylase
YE3444	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
YE3445	COG0741	lytic transglycosylase activity
YE3447	COG1982	Orn Lys Arg decarboxylase major
YE3450	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
YE3454	COG3210	domain, Protein
YE3456	COG2801	Transposase and inactivated derivatives
YE3475	COG1393	Belongs to the ArsC family
YE3477	COG0431	NADPH-dependent FMN reductase
YE3514	COG0305	Participates in initiation and elongation during chromosome replication
YE3526	COG0531	amino acid
YE3527	COG1982	Orn Lys Arg decarboxylase major
YE3529	COG1289	transmembrane transporter activity
YE3560	COG2197	response regulator
YE3566	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
YE3568	COG2165	general secretion pathway protein
YE3574	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
YE3576	COG3397	chitin binding
YE3582	COG0024	Methionine aminopeptidase
YE3583	COG4604	ABC transporter, ATP-binding protein
YE3584	COG4605	iron ion homeostasis
YE3586	COG4607	ABC-type enterochelin transport system periplasmic component
YE3588	COG0477	Major facilitator Superfamily
YE3589	COG1609	Transcriptional regulator
YE3591	COG1283	sodium-dependent phosphate transmembrane transporter activity
YE3594	COG0477	Major facilitator Superfamily
YE3597	COG5001	Diguanylate cyclase
YE3599	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
YE3600	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
YE3601	COG0309	Hydrogenase expression formation protein (HypE)
YE3602	COG0409	Hydrogenase expression formation protein
YE3602A	COG0298	carbon dioxide binding
YE3603	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
YE3604	COG1773	rubredoxin
YE3605	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
YE3606	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
YE3607	COG5557	Pfam Polysulphide reductase, NrfD
YE3608	COG0437	4 iron, 4 sulfur cluster binding
YE3609	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
YE3610	COG3133	Outer membrane lipoprotein
YE3611	COG3710	Transcriptional regulator
YE3615	COG0840	transmembrane signaling receptor activity
YE3616	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
YE3617	COG2271	Major facilitator Superfamily
YE3618	COG4592	Periplasmic binding protein
YE3619	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
YE3620	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
YE3621	COG1120	ATPase activity
YE3629	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
YE3630	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
YE3636	COG4964	Belongs to the GSP D family
YE3645	COG0848	biopolymer transport protein
YE3648	COG0586	Pfam SNARE associated Golgi protein
YE3649	COG2207	Transcriptional regulator
YE3651	COG1979	alcohol dehydrogenase
YE3652	COG0656	L-ascorbic acid biosynthetic process
YE3654	COG2132	Multicopper oxidase
YE3656	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
YE3657	COG2249	NAD(P)H dehydrogenase (quinone) activity
YE3658	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
YE3661	COG3150	esterase
YE3662	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
YE3663	COG3151	Protein conserved in bacteria
YE3664	COG0494	nUDIX hydrolase
YE3665	COG1538	Outer membrane efflux protein
YE3666	COG5463	Belongs to the UPF0441 family
YE3667	COG0754	glutathionylspermidine amidase activity
YE3668	COG3384	dioxygenase
YE3669	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
YE3672	COG0531	amino acid
YE3673	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
YE3673	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
YE3674	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
YE3675	COG3025	triphosphatase activity
YE3676	COG4991	sh3 domain protein
YE3677	COG0617	tRNA 3'-terminal CCA addition
YE3678	COG1968	undecaprenyl-diphosphatase activity
YE3679	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
YE3680	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
YE3681	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
YE3682	COG0828	Belongs to the bacterial ribosomal protein bS21 family
YE3683	COG0358	DNA primase activity
YE3685	COG3876	Protein conserved in bacteria
YE3687	COG1472	Belongs to the glycosyl hydrolase 3 family
YE3689	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
YE3690	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
YE3690	COG1263	PTS System
YE3692	COG0531	amino acid
YE3693	COG0076	glutamate decarboxylase activity
YE3695	COG2814	Major facilitator Superfamily
YE3696	COG3247	response to pH
YE3698	COG1902	pentaerythritol trinitrate reductase activity
YE3698	COG0446	pyridine nucleotide-disulphide oxidoreductase
YE3699	COG2813	Specifically methylates the guanine in position
YE3701	COG1451	nucleotide metabolic process
YE3702	COG0673	inositol 2-dehydrogenase activity
YE3703	COG0861	Integral membrane protein TerC family
YE3704	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
YE3706	COG2721	sulfolactate sulfo-lyase activity
YE3707	COG0246	Mannitol dehydrogenase
YE3708	COG1904	glucuronate isomerase
YE3709	COG2271	Major facilitator Superfamily
YE3712	COG0586	Pfam SNARE associated Golgi protein
YE3715	COG4575	ribosome binding
YE3716	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
YE3718	COG2259	Doxx family
YE3719	COG0435	Glutathione S-transferase
YE3720	COG0583	DNA-binding transcription factor activity
YE3721	COG1741	Belongs to the pirin family
YE3722	COG1064	alcohol dehydrogenase
YE3723	COG0667	Aldo Keto reductase
YE3726	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
YE3728	COG0792	nuclease activity
YE3729	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
YE3730	COG2823	Periplasmic or secreted lipoprotein
YE3731	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
YE3732	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
YE3733	COG2198	Histidine kinase
YE3733	COG0784	Response regulator, receiver
YE3733	COG5002	protein histidine kinase activity
YE3734	COG1242	4 iron, 4 sulfur cluster binding
YE3735	COG0067	glutamate synthase
YE3735	COG0070	glutamate synthase
YE3735	COG0069	glutamate synthase activity
YE3736	COG0493	'glutamate synthase
YE3738	COG2969	positive regulation of protein catabolic process
YE3739	COG0625	glutathione transferase activity
YE3740	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
YE3741	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
YE3742	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
YE3743	COG3105	Protein conserved in bacteria
YE3744	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
YE3745	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
YE3746	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
YE3747	COG5007	Belongs to the BolA IbaG family
YE3748	COG3113	response to antibiotic
YE3749	COG2854	intermembrane phospholipid transfer
YE3750	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
YE3751	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
YE3752	COG1127	ABC transporter
YE3753	COG0530	calcium, potassium:sodium antiporter activity
YE3754	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
YE3754	COG0517	IMP dehydrogenase activity
YE3755	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
YE3756	COG3117	lipopolysaccharide transmembrane transporter activity
YE3757	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
YE3758	COG1137	ATPase activity
YE3759	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
YE3762	COG1660	Displays ATPase and GTPase activities
YE3763	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
YE3766	COG0540	Belongs to the ATCase OTCase family
YE3767	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
YE3769	COG2308	Evidence 4 Homologs of previously reported genes of
YE3773	COG0366	Alpha amylase catalytic
YE3774	COG1263	PTS System
YE3774	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
YE3776	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
YE3777	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
YE3777	COG3711	transcriptional antiterminator
YE3778	COG2706	6-phosphogluconolactonase activity
YE3781	COG3964	amidohydrolase
YE3787	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
YE3788	COG3783	Cytochrome b(562)
YE3789	COG0312	modulator of DNA gyrase
YE3790	COG3028	Belongs to the UPF0307 family
YE3791	COG2732	(Barnase) inhibitor
YE3794	COG1289	transmembrane transporter activity
YE3795	COG1566	PFAM secretion protein HlyD family protein
YE3797	COG0583	DNA-binding transcription factor activity
YE3798	COG0312	modulator of DNA gyrase
YE3799	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
YE3800	COG3164	Protein of unknown function
YE3801	COG1530	ribonuclease E activity
YE3802	COG0424	maF-like protein
YE3803	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
YE3804	COG1792	Involved in formation and maintenance of cell shape
YE3805	COG1077	Cell shape determining protein MreB Mrl
YE3806	COG2200	EAL domain
YE3806	COG2199	diguanylate cyclase activity
YE3807	COG0604	alcohol dehydrogenase
YE3809	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
YE3810	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
YE3811	COG0511	ligase activity, forming carbon-carbon bonds
YE3812	COG0439	Biotin carboxylase
YE3813	COG3924	membrane
YE3814	COG4145	pantothenate transmembrane transporter activity
YE3815	COG2264	protein methyltransferase activity
YE3816	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
YE3817	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
YE3819	COG3133	Outer membrane lipoprotein
YE3821	COG1278	Cold shock
YE3822	COG1278	Cold shock
YE3823	COG1278	Cold shock
YE3827	COG0471	metal ion transport
YE3829	COG1560	Kdo2-lipid A biosynthetic process
YE3830	COG2801	Transposase and inactivated derivatives
YE3831	COG2963	transposase activity
YE3833	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
YE3834	COG4597	amino acid ABC transporter
YE3835	COG0765	amino acid transport
YE3836	COG1126	abc transporter atp-binding protein
YE3838	COG0583	DNA-binding transcription factor activity
YE3839	COG0025	NhaP-type Na H and K H
YE3840	COG2252	PERMEase
YE3843	COG3550	peptidyl-serine autophosphorylation
YE3845	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
YE3846	COG2315	Protein conserved in bacteria
YE3847	COG1448	Aminotransferase
YE3852	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
YE3853	COG0735	belongs to the Fur family
YE3854	COG3237	CsbD-like
YE3855	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
YE3856	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
YE3857	COG2937	Belongs to the GPAT DAPAT family
YE3858	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
YE3859	COG3161	chorismate lyase activity
YE3862	COG4580	involved in the transport of maltose and maltodextrins
YE3866	COG2182	Extracellular solute-binding protein
YE3867	COG1175	transmembrane transport
YE3868	COG3833	ABC-type maltose transport systems, permease component
YE3869	COG3223	Belongs to the PsiE family
YE3870	COG0166	Belongs to the GPI family
YE3873	COG0527	aspartate kinase activity
YE3875	COG0646	methionine synthase
YE3875	COG1410	methionine synthase
YE3876	COG1414	Transcriptional regulator
YE3879	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
YE3881	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
YE3882	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
YE3883	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
YE3884	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
YE3885	COG0009	L-threonylcarbamoyladenylate synthase
YE3886	COG0551	DNA topoisomerase type I activity
YE3888	COG0758	DNA mediated transformation
YE3889	COG0242	peptide deformylase activity
YE3890	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
YE3891	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
YE3891	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
YE3893	COG1970	mechanosensitive ion channel activity
YE3894	COG3036	rescue of stalled ribosome
YE3895	COG0789	Transcriptional regulator
YE3897	COG0203	ribosomal protein L17
YE3898	COG0202	RNA polymerase activity
YE3899	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
YE3900	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
YE3901	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
YE3902	COG0257	Belongs to the bacterial ribosomal protein bL36 family
YE3903	COG0201	protein transport
YE3904	COG0200	Binds to the 23S rRNA
YE3905	COG1841	ribosomal large subunit assembly
YE3906	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
YE3907	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
YE3908	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
YE3909	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
YE3910	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
YE3911	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
YE3912	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
YE3913	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
YE3914	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
YE3915	COG0255	Belongs to the universal ribosomal protein uL29 family
YE3916	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
YE3917	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
YE3918	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
YE3919	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
YE3920	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
YE3921	COG0089	rRNA binding
YE3922	COG0088	Forms part of the polypeptide exit tunnel
YE3923	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
YE3924	COG0051	transcription antitermination factor activity, RNA binding
YE3927	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
YE3928	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
YE3929	COG0049	tRNA binding
YE3930	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
YE3931	COG2168	tRNA wobble position uridine thiolation
YE3932	COG2923	Belongs to the DsrF TusC family
YE3933	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
YE3934	COG2964	Protein conserved in bacteria
YE3935	COG0545	Peptidyl-prolyl cis-trans isomerase
YE3936	COG2900	Belongs to the SlyX family
YE3938	COG1047	Peptidyl-prolyl cis-trans
YE3939	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
YE3941	COG2249	NAD(P)H dehydrogenase (quinone) activity
YE3942	COG0488	(ABC) transporter
YE3943	COG1216	Glycosyl transferase, family 2
YE3945	COG2175	clavaminate synthase activity
YE3946	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
YE3948	COG4521	taurine ABC transporter
YE3951	COG0429	hydrolase of the alpha beta-hydrolase fold
YE3952	COG3089	Belongs to the UPF0270 family
YE3953	COG3954	Phosphoribulokinase
YE3954	COG1765	OsmC-like protein
YE3956	COG1289	transmembrane transporter activity
YE3959	COG0433	COG0433 Predicted ATPase
YE3960	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
YE3961	COG1486	melibiose metabolic process
YE3963	COG0738	Major facilitator superfamily
YE3964	COG0402	S-adenosylhomocysteine deaminase activity
YE3965	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
YE3968	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
YE3968	COG1648	precorrin-2 dehydrogenase activity
YE3969	COG0180	Tryptophanyl-tRNA synthetase
YE3971	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
YE3975	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
YE3976	COG4796	Type ii and iii secretion system protein
YE3979	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
YE3980	COG0494	nUDIX hydrolase
YE3983	COG1011	Hydrolase
YE3984	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
YE3986	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
YE3987	COG1349	DNA-binding transcription factor activity
YE3988	COG0705	Rhomboid family
YE3990	COG2909	trisaccharide binding
YE3991	COG0058	SHG alpha-glucan phosphorylase activity
YE3992	COG1640	4-alpha-glucanotransferase
YE3993	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
YE3993	COG0316	Belongs to the HesB IscA family
YE3995	COG0596	Alpha beta hydrolase
YE3998	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
YE3999	COG1918	ferrous iron import across plasma membrane
YE4000	COG2183	response to ionizing radiation
YE4003	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
YE4008	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
YE4009	COG0058	SHG alpha-glucan phosphorylase activity
YE4010	COG0297	glycogen (starch) synthase activity
YE4012	COG1523	belongs to the glycosyl hydrolase 13 family
YE4013	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
YE4014	COG3275	phosphorelay sensor kinase activity
YE4018	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
YE4019	COG2095	MarC family integral membrane protein
YE4020	COG3265	gluconokinase activity
YE4021	COG2610	gluconate transmembrane transporter activity
YE4022	COG1609	Transcriptional regulator
YE4023	COG1741	Belongs to the pirin family
YE4024	COG1247	-acetyltransferase
YE4025	COG1082	Xylose isomerase domain protein TIM barrel
YE4026	COG0673	inositol 2-dehydrogenase activity
YE4028	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
YE4030	COG3718	enzyme involved in inositol metabolism
YE4032	COG2814	Major facilitator Superfamily
YE4033	COG0583	DNA-binding transcription factor activity
YE4034	COG0561	phosphatase activity
YE4036	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
YE4036	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
YE4037	COG0583	DNA-binding transcription factor activity
YE4038	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
YE4038	COG1648	precorrin-2 dehydrogenase activity
YE4040	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
YE4042	COG4865	methylaspartate mutase activity
YE4043	COG3799	methylaspartate ammonia-lyase activity
YE4046	COG1301	dicarboxylic acid transport
YE4047	COG2081	HI0933 family
YE4048	COG0306	phosphate transporter
YE4050	COG0589	response to stress
YE4052	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
YE4053	COG0742	ribosomal rna small subunit methyltransferase
YE4055	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
YE4057	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
YE4060	COG1295	ribonuclease BN
YE4061	COG2134	cdp-diacylglycerol pyrophosphatase
YE4062	COG2982	Protein involved in outer membrane biogenesis
YE4063	COG2200	EAL domain
YE4064	COG1942	4-Oxalocrotonate Tautomerase
YE4065	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
YE4066	COG0612	Peptidase, M16
YE4067	COG1301	dicarboxylic acid transport
YE4070	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
YE4071	COG2199	diguanylate cyclase activity
YE4071	COG2200	EAL domain
YE4072	COG3118	belongs to the thioredoxin family
YE4072	COG0457	Tetratricopeptide repeat
YE4072A	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
YE4073	COG1215	transferase activity, transferring glycosyl groups
YE4074	COG1215	transferase activity, transferring glycosyl groups
YE4075	COG1192	Involved in chromosome partitioning
YE4078	COG2194	sulfuric ester hydrolase activity
YE4079	COG4608	Belongs to the ABC transporter superfamily
YE4080	COG0444	Belongs to the ABC transporter superfamily
YE4081	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
YE4082	COG0601	transmembrane transport
YE4083	COG0747	negative chemotaxis
YE4084	COG3210	domain, Protein
YE4085	COG2831	hemolysin activation secretion protein
YE4086	COG3210	domain, Protein
YE4087	COG2271	Major facilitator Superfamily
YE4088	COG3851	Histidine kinase
YE4089	COG2197	response regulator
YE4090	COG2194	sulfuric ester hydrolase activity
YE4091	COG1764	response to oxidative stress
YE4094	COG2986	histidine ammonia-lyase
YE4095	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
YE4098	COG1482	cell wall glycoprotein biosynthetic process
YE4099	COG2723	6-phospho-beta-galactosidase activity
YE4102	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
YE4103	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
YE4104	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
YE4105	COG1447	Phosphotransferase system cellobiose-specific component IIA
YE4106	COG1940	carbohydrate kinase activity
YE4107	COG1609	Transcriptional regulator
YE4112	COG3177	Filamentation induced by cAMP protein fic
YE4117	COG0582	viral genome integration into host DNA
YE4118	COG2207	Transcriptional regulator
YE4118	COG1609	Transcriptional regulator
YE4119	COG4214	carbohydrate transport
YE4121	COG4213	ABC transporter substrate-binding protein
YE4122	COG2115	Belongs to the xylose isomerase family
YE4123	COG1070	Carbohydrate kinase
YE4123A	COG3121	Chaperone
YE4126	COG3274	enterobacterial common antigen metabolic process
YE4128	COG3550	peptidyl-serine autophosphorylation
YE4130	COG3276	selenocysteine insertion sequence binding
YE4131	COG1921	L-seryl-tRNASec selenium transferase activity
YE4132	COG3058	Necessary for formate dehydrogenase activity
YE4133	COG2864	formate dehydrogenase
YE4134	COG0437	4 iron, 4 sulfur cluster binding
YE4137	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
YE4138	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
YE4139	COG0840	transmembrane signaling receptor activity
YE4140	COG2258	MOSC domain
YE4144	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
YE4146	COG3722	fumarate hydratase activity
YE4147	COG0246	Mannitol dehydrogenase
YE4148	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
YE4148	COG2213	PTS system mannitol-specific
YE4150	COG0751	glycine-tRNA ligase activity
YE4151	COG0752	glycyl-tRNA synthetase alpha subunit
YE4152	COG2818	Glycosylase
YE4153	COG0456	acetyltransferase
YE4156	COG2885	chlorophyll binding
YE4159	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
YE4160	COG0366	Alpha amylase catalytic
YE4161	COG3977	Valine--pyruvate aminotransferase
YE4162	COG0569	domain protein
YE4162	COG2985	domain, Protein
YE4165	COG5645	(Lipo)protein
YE4166	COG0823	Involved in the tonB-independent uptake of proteins
YE4167	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
YE4168	COG2423	ornithine cyclodeaminase activity
YE4169	COG0561	phosphatase activity
YE4170	COG0187	DNA topoisomerase II activity
YE4171	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
YE4172	COG0592	DNA-directed DNA polymerase activity
YE4173	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
YE4175	COG0230	Belongs to the bacterial ribosomal protein bL34 family
YE4176	COG0594	ribonuclease P activity
YE4177	COG0706	membrane insertase activity
YE4178	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
YE4179	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
YE4182	COG2011	ABC-type metal ion transport system permease component
YE4183	COG0840	transmembrane signaling receptor activity
YE4184	COG0431	NADPH-dependent FMN reductase
YE4186	COG4566	intracellular signal transduction
YE4188	COG2252	PERMEase
YE4189	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
YE4190	COG0765	amino acid transport
YE4191	COG0765	amino acid transport
YE4193	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
YE4196	COG0704	Plays a role in the regulation of phosphate uptake
YE4199	COG0581	inorganic phosphate transmembrane transporter activity
YE4200	COG0573	inorganic phosphate transmembrane transporter activity
YE4201	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
YE4204	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
YE4205	COG0355	proton-transporting ATP synthase activity, rotational mechanism
YE4206	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
YE4207	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
YE4208	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
YE4209	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
YE4210	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
YE4212	COG0356	it plays a direct role in the translocation of protons across the membrane
YE4213	COG3312	ion transport
YE4214	COG0357	Ribosomal RNA small subunit methyltransferase G
YE4215	COG0445	tRNA wobble uridine modification
YEP0003	COG2502	aspartate--ammonia ligase
YEP0033	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
YEP0042	COG3078	GTPase activator activity
YEP0045	COG0635	Involved in the biosynthesis of porphyrin-containing compound
YEP0084	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
YEP0086	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA