locus-tag	class	description
Y11_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Y11_RS00010	COG1393	Belongs to the ArsC family
Y11_RS00015	COG4783	chaperone-mediated protein folding
Y11_RS00020	COG0628	permease
Y11_RS00025	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Y11_RS00030	COG2716	regulation of RNA biosynthetic process
Y11_RS00035	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Y11_RS00040	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
Y11_RS00045	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Y11_RS00050	COG2321	neutral zinc metallopeptidase
Y11_RS00055	COG2707	UPF0756 membrane protein
Y11_RS00060	COG1444	tRNA N-acetyltransferase activity
Y11_RS00075	COG0400	carboxylic ester hydrolase activity
Y11_RS00130	COG1876	peptidase activity
Y11_RS00135	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Y11_RS00140	COG1393	Belongs to the ArsC family
Y11_RS00155	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Y11_RS00165	COG2197	response regulator
Y11_RS00175	COG3062	negative regulation of establishment of protein localization
Y11_RS00180	COG0243	molybdopterin cofactor binding
Y11_RS00185	COG3043	anaerobic respiration
Y11_RS00190	COG3005	denitrification pathway
Y11_RS00195	COG0494	nUDIX hydrolase
Y11_RS00200	COG0281	malic enzyme
Y11_RS00200	COG0280	phosphate acetyltransferase
Y11_RS00220	COG1671	Belongs to the UPF0178 family
Y11_RS00225	COG0408	coproporphyrinogen oxidase activity
Y11_RS00230	COG0456	acetyltransferase
Y11_RS00235	COG3111	PFAM Bacterial OB fold (BOF) protein
Y11_RS00245	COG2837	iron assimilation
Y11_RS00255	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Y11_RS00270	COG2731	YhcH YjgK YiaL family protein
Y11_RS00275	COG1737	Transcriptional regulator
Y11_RS00285	COG4150	thiosulfate binding
Y11_RS00290	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
Y11_RS00295	COG4208	sulfate ABC transporter
Y11_RS00315	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Y11_RS00325	COG2205	protein histidine kinase activity
Y11_RS00335	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Y11_RS00340	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
Y11_RS00360	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Y11_RS00365	COG3530	Putative quorum-sensing-regulated virulence factor
Y11_RS00390	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Y11_RS00415	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
Y11_RS00420	COG1914	H( )-stimulated, divalent metal cation uptake system
Y11_RS00430	COG0667	Aldo Keto reductase
Y11_RS00435	COG3961	Belongs to the TPP enzyme family
Y11_RS00450	COG0837	glucose binding
Y11_RS00460	COG2223	nitrite transmembrane transporter activity
Y11_RS00465	COG3279	Response regulator of the LytR AlgR family
Y11_RS00470	COG3275	phosphorelay sensor kinase activity
Y11_RS00485	COG0436	Aminotransferase
Y11_RS00490	COG3038	cytochrome b561
Y11_RS00495	COG1598	PFAM Uncharacterised protein family UPF0150
Y11_RS00505	COG1280	lysine exporter protein (LysE YggA)
Y11_RS00525	COG2951	lytic endotransglycosylase activity
Y11_RS00530	COG0531	amino acid
Y11_RS00550	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
Y11_RS00555	COG1127	ABC transporter
Y11_RS00575	COG2755	lipolytic protein G-D-S-L family
Y11_RS00575	COG0657	acetylesterase activity
Y11_RS00580	COG3038	cytochrome b561
Y11_RS00590	COG1609	Transcriptional regulator
Y11_RS00595	COG1263	PTS System
Y11_RS00595	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Y11_RS00600	COG2723	6-phospho-beta-galactosidase activity
Y11_RS00610	COG1695	Transcriptional regulator
Y11_RS00615	COG2824	Alkylphosphonate utilization operon protein PhnA
Y11_RS00630	COG2116	formate transmembrane transporter activity
Y11_RS00640	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Y11_RS00645	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Y11_RS00650	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Y11_RS00655	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
Y11_RS00660	COG1138	Cytochrome C-type biogenesis protein
Y11_RS00665	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Y11_RS00675	COG4235	cytochrome complex assembly
Y11_RS00675	COG3088	subunit of a heme lyase
Y11_RS00690	COG3691	Protein conserved in bacteria
Y11_RS00695	COG0183	Belongs to the thiolase family
Y11_RS00700	COG1250	3-hydroxyacyl-CoA dehydrogenase
Y11_RS00700	COG1024	Enoyl-CoA hydratase
Y11_RS00705	COG2062	phosphohistidine phosphatase, SixA
Y11_RS00710	COG2840	Smr protein MutS2
Y11_RS00715	COG2890	protein-(glutamine-N5) methyltransferase activity
Y11_RS00720	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Y11_RS00725	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
Y11_RS00730	COG0730	response to heat
Y11_RS00735	COG3101	peptidyl-lysine hydroxylation
Y11_RS00745	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
Y11_RS00745	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Y11_RS00750	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Y11_RS00760	COG1794	racemase activity, acting on amino acids and derivatives
Y11_RS00770	COG1447	Phosphotransferase system cellobiose-specific component IIA
Y11_RS00775	COG2723	6-phospho-beta-galactosidase activity
Y11_RS00780	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
Y11_RS00790	COG1609	Transcriptional regulator
Y11_RS00800	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
Y11_RS00825	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Y11_RS00830	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Y11_RS00835	COG0697	spore germination
Y11_RS00840	COG0697	spore germination
Y11_RS00850	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Y11_RS00855	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
Y11_RS00865	COG0586	Pfam SNARE associated Golgi protein
Y11_RS00870	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
Y11_RS00875	COG0285	dihydrofolate synthase activity
Y11_RS00880	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
Y11_RS00885	COG1286	toxin biosynthetic process
Y11_RS00890	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
Y11_RS00895	COG0163	prenyltransferase activity
Y11_RS00900	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Y11_RS00905	COG4215	(ABC) transporter
Y11_RS00910	COG4160	amino acid transport
Y11_RS00915	COG4598	ABC transporter
Y11_RS00930	COG1090	epimerase
Y11_RS00940	COG0622	Phosphoesterase
Y11_RS00945	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
Y11_RS00955	COG3037	sugar-specific permease SgaT UlaA
Y11_RS00965	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Y11_RS00970	COG1609	Transcriptional regulator
Y11_RS00975	COG0280	phosphate acetyltransferase
Y11_RS00975	COG0857	belongs to the CobB CobQ family
Y11_RS00985	COG3092	negative regulation of chromosome organization
Y11_RS00990	COG3013	Belongs to the UPF0304 family
Y11_RS00995	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Y11_RS01005	COG0490	domain, Protein
Y11_RS01005	COG0471	metal ion transport
Y11_RS01010	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
Y11_RS01015	COG0436	Aminotransferase
Y11_RS01020	COG0583	DNA-binding transcription factor activity
Y11_RS01025	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Y11_RS01030	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Y11_RS01035	COG0649	NAD binding
Y11_RS01035	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Y11_RS01050	COG1034	ATP synthesis coupled electron transport
Y11_RS01055	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
Y11_RS01060	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Y11_RS01065	COG0839	Belongs to the complex I subunit 6 family
Y11_RS01070	COG0713	ATP synthesis coupled electron transport
Y11_RS01075	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Y11_RS01080	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Y11_RS01085	COG1007	ATP synthesis coupled electron transport
Y11_RS01105	COG3265	gluconokinase activity
Y11_RS01110	COG1028	Short-chain dehydrogenase reductase Sdr
Y11_RS01115	COG1609	Transcriptional regulator
Y11_RS01130	COG4702	Belongs to the UPF0303 family
Y11_RS01135	COG0129	dihydroxy-acid dehydratase activity
Y11_RS01140	COG4575	ribosome binding
Y11_RS01145	COG1169	isochorismate synthase
Y11_RS01150	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
Y11_RS01155	COG0596	Alpha beta hydrolase
Y11_RS01160	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
Y11_RS01165	COG1441	menaquinone biosynthetic process
Y11_RS01185	COG0814	amino acid
Y11_RS01220	COG4574	serine-type endopeptidase inhibitor activity
Y11_RS01225	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Y11_RS01235	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Y11_RS01240	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Y11_RS01250	COG0784	Response regulator, receiver
Y11_RS01250	COG2205	protein histidine kinase activity
Y11_RS01255	COG2197	response regulator
Y11_RS01260	COG0642	Histidine kinase
Y11_RS01260	COG2198	Histidine kinase
Y11_RS01265	COG2223	nitrite transmembrane transporter activity
Y11_RS01275	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
Y11_RS01290	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
Y11_RS01335	COG1737	Transcriptional regulator
Y11_RS01340	COG2190	(PTS) system
Y11_RS01340	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Y11_RS01340	COG1263	PTS System
Y11_RS01345	COG2723	6-phospho-beta-galactosidase activity
Y11_RS01355	COG3328	transposase activity
Y11_RS01380	COG3082	Protein of unknown function (DUF1414)
Y11_RS01385	COG3081	Nucleoid-associated protein
Y11_RS01390	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
Y11_RS01395	COG1061	Type III restriction enzyme res subunit
Y11_RS01400	COG1187	pseudouridine synthase activity
Y11_RS01405	COG2814	Major facilitator Superfamily
Y11_RS01415	COG4172	Belongs to the ABC transporter superfamily
Y11_RS01420	COG4239	(ABC) transporter, permease
Y11_RS01425	COG4174	ABC transporter (Permease)
Y11_RS01430	COG4166	transmembrane transport
Y11_RS01435	COG2200	EAL domain
Y11_RS01445	COG0791	NLP P60 protein
Y11_RS01450	COG0671	phosphoesterase, PA-phosphatase related
Y11_RS01455	COG0523	cobalamin synthesis protein
Y11_RS01465	COG2186	Transcriptional regulator
Y11_RS01470	COG0246	Mannitol dehydrogenase
Y11_RS01480	COG1312	Catalyzes the dehydration of D-mannonate
Y11_RS01485	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Y11_RS01500	COG0243	molybdopterin cofactor binding
Y11_RS01505	COG3005	denitrification pathway
Y11_RS01520	COG1105	Belongs to the carbohydrate kinase PfkB family
Y11_RS01530	COG3710	Transcriptional regulator
Y11_RS01555	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
Y11_RS01560	COG2855	membrane
Y11_RS01575	COG0583	DNA-binding transcription factor activity
Y11_RS01580	COG0833	amino acid
Y11_RS01585	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Y11_RS01595	COG4771	TonB-dependent receptor
Y11_RS01600	COG0625	glutathione transferase activity
Y11_RS01625	COG2011	ABC-type metal ion transport system permease component
Y11_RS01630	COG0626	cystathionine gamma-synthase activity
Y11_RS01640	COG1686	Belongs to the peptidase S11 family
Y11_RS01650	COG1760	l-serine dehydratase
Y11_RS01655	COG0814	amino acid
Y11_RS01660	COG1349	DNA-binding transcription factor activity
Y11_RS01665	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
Y11_RS01670	COG0671	phosphoesterase, PA-phosphatase related
Y11_RS01680	COG2985	domain, Protein
Y11_RS01680	COG0569	domain protein
Y11_RS01700	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
Y11_RS01705	COG3842	ATPase activity
Y11_RS01710	COG1176	ABC-type spermidine putrescine transport system, permease component I
Y11_RS01715	COG1177	transmembrane transport
Y11_RS01725	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Y11_RS01730	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Y11_RS01735	COG4160	amino acid transport
Y11_RS01740	COG4215	(ABC) transporter
Y11_RS01745	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Y11_RS01750	COG1126	abc transporter atp-binding protein
Y11_RS01760	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Y11_RS01765	COG0702	epimerase
Y11_RS01770	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
Y11_RS01780	COG0028	Belongs to the TPP enzyme family
Y11_RS01785	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Y11_RS01790	COG1151	hydroxylamine reductase activity
Y11_RS01795	COG2431	L-lysine efflux transmembrane transporter activity
Y11_RS01800	COG3593	DNA synthesis involved in DNA repair
Y11_RS01805	COG2990	Protein conserved in bacteria
Y11_RS01810	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Y11_RS01820	COG1278	Cold shock
Y11_RS01825	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
Y11_RS01830	COG0542	response to heat
Y11_RS01835	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
Y11_RS01840	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
Y11_RS01845	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
Y11_RS01855	COG0492	ferredoxin-NADP+ reductase activity
Y11_RS01860	COG1522	sequence-specific DNA binding
Y11_RS01865	COG1674	ftsk spoiiie
Y11_RS01865	COG3107	peptidoglycan biosynthetic process
Y11_RS01870	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
Y11_RS01875	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
Y11_RS01880	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Y11_RS01890	COG3328	transposase activity
Y11_RS01895	COG2814	Major facilitator Superfamily
Y11_RS01900	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
Y11_RS01905	COG1882	Formate acetyltransferase
Y11_RS01910	COG2116	formate transmembrane transporter activity
Y11_RS01925	COG1944	ATP diphosphatase activity
Y11_RS01935	COG2323	membrane
Y11_RS01940	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
Y11_RS01945	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
Y11_RS01950	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
Y11_RS01955	COG0539	negative regulation of cytoplasmic translation
Y11_RS01960	COG0776	regulation of translation
Y11_RS01965	COG2333	competence protein COMEC
Y11_RS01965	COG0658	competence protein
Y11_RS01975	COG1663	tetraacyldisaccharide 4'-kinase activity
Y11_RS01980	COG5383	Protein conserved in bacteria
Y11_RS01990	COG1278	Cold shock
Y11_RS01995	COG2835	tetraacyldisaccharide 4'-kinase activity
Y11_RS02000	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
Y11_RS02005	COG3173	Aminoglycoside phosphotransferase
Y11_RS02010	COG1434	Gram-negative-bacterium-type cell wall biogenesis
Y11_RS02015	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Y11_RS02020	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
Y11_RS02030	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
Y11_RS02035	COG2989	Protein conserved in bacteria
Y11_RS02040	COG3108	Peptidase M15
Y11_RS02045	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Y11_RS02050	COG2200	EAL domain
Y11_RS02060	COG1448	Aminotransferase
Y11_RS02070	COG0017	Asparaginyl-tRNA synthetase
Y11_RS02075	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
Y11_RS02080	COG0308	aminopeptidase N
Y11_RS02085	COG0167	dihydroorotate dehydrogenase activity
Y11_RS02095	COG3217	Mosc domain protein beta barrel domain protein
Y11_RS02095	COG0633	Ferredoxin
Y11_RS02100	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
Y11_RS02100	COG0116	Belongs to the methyltransferase superfamily
Y11_RS02105	COG0488	(ABC) transporter
Y11_RS02110	COG2995	paraquat-inducible protein a
Y11_RS02115	COG3008	intermembrane lipid transfer
Y11_RS02115	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
Y11_RS02120	COG3009	Protein conserved in bacteria
Y11_RS02125	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Y11_RS02135	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Y11_RS02140	COG1067	ATP-dependent peptidase activity
Y11_RS02145	COG3120	sequence-specific DNA binding
Y11_RS02155	COG5404	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
Y11_RS02165	COG1289	transmembrane transporter activity
Y11_RS02170	COG3304	Inner membrane component domain
Y11_RS02175	COG0210	DNA helicase
Y11_RS02180	COG1803	Methylglyoxal synthase
Y11_RS02190	COG1832	CoA-binding protein
Y11_RS02195	COG3785	DNA binding
Y11_RS02200	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
Y11_RS02215	COG1254	Belongs to the acylphosphatase family
Y11_RS02220	COG2920	part of a sulfur-relay system
Y11_RS02235	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
Y11_RS02240	COG0437	4 iron, 4 sulfur cluster binding
Y11_RS02245	COG3301	Polysulphide reductase, NrfD
Y11_RS02250	COG1138	Cytochrome C-type biogenesis protein
Y11_RS02255	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Y11_RS02260	COG3088	subunit of a heme lyase
Y11_RS02265	COG4235	cytochrome complex assembly
Y11_RS02270	COG2771	luxR family
Y11_RS02275	COG3916	Acyl-homoserine-lactone synthase
Y11_RS02285	COG3263	regulation of cellular component size
Y11_RS02305	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
Y11_RS02310	COG2943	transferase activity, transferring hexosyl groups
Y11_RS02330	COG2259	Doxx family
Y11_RS02340	COG1560	Kdo2-lipid A biosynthetic process
Y11_RS02375	COG1054	Belongs to the UPF0176 family
Y11_RS02380	COG0628	permease
Y11_RS02405	COG0418	dihydroorotase activity
Y11_RS02410	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
Y11_RS02415	COG1530	ribonuclease E activity
Y11_RS02415	COG1530	ribonuclease E activity
Y11_RS02420	COG0564	pseudouridine synthase activity
Y11_RS02425	COG0424	maF-like protein
Y11_RS02430	COG1399	metal-binding, possibly nucleic acid-binding protein
Y11_RS02435	COG0333	Belongs to the bacterial ribosomal protein bL32 family
Y11_RS02440	COG0416	fatty acid biosynthetic process
Y11_RS02445	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Y11_RS02450	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
Y11_RS02455	COG1028	Short-chain dehydrogenase reductase Sdr
Y11_RS02465	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Y11_RS02470	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Y11_RS02475	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
Y11_RS02480	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Y11_RS02485	COG0470	DNA polymerase III
Y11_RS02490	COG0084	hydrolase, TatD family'
Y11_RS02495	COG1263	PTS System
Y11_RS02495	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Y11_RS02515	COG0641	radical SAM
Y11_RS02525	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Y11_RS02530	COG0537	adenosine 5'-monophosphoramidase activity
Y11_RS02535	COG5633	Lipoprotein
Y11_RS02540	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
Y11_RS02550	COG1472	Belongs to the glycosyl hydrolase 3 family
Y11_RS02555	COG3150	esterase
Y11_RS02560	COG1252	NADH dehydrogenase
Y11_RS02565	COG3134	Outer membrane lipoprotein
Y11_RS02570	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
Y11_RS02575	COG4591	ABC-type transport system involved in lipoprotein release permease component
Y11_RS02585	COG4591	ABC-type transport system involved in lipoprotein release permease component
Y11_RS02590	COG1940	carbohydrate kinase activity
Y11_RS02605	COG2850	peptidyl-arginine hydroxylation
Y11_RS02615	COG0745	RESPONSE REGULATOR receiver
Y11_RS02625	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
Y11_RS02630	COG2915	High frequency lysogenization protein hflD homolog
Y11_RS02635	COG0482	sulfurtransferase activity
Y11_RS02645	COG1187	pseudouridine synthase activity
Y11_RS02650	COG0538	isocitrate dehydrogenase activity
Y11_RS02690	COG0538	isocitrate dehydrogenase activity
Y11_RS02725	COG0840	transmembrane signaling receptor activity
Y11_RS02745	COG2873	o-acetylhomoserine
Y11_RS02750	COG0702	epimerase
Y11_RS02755	COG1733	regulation of RNA biosynthetic process
Y11_RS02780	COG3755	Protein conserved in bacteria
Y11_RS02795	COG5001	Diguanylate cyclase
Y11_RS02795	COG4251	negative regulation of phosphorylation
Y11_RS02795	COG3706	GGDEF domain
Y11_RS02795	COG2203	Gaf domain
Y11_RS02815	COG1132	(ABC) transporter
Y11_RS02835	COG2207	Transcriptional regulator
Y11_RS02870	COG1113	amino acid transport
Y11_RS02890	COG1496	oxidoreductase activity
Y11_RS02900	COG2226	methyltransferase
Y11_RS02910	COG3447	MASE1 domain protein
Y11_RS02910	COG5001	Diguanylate cyclase
Y11_RS02910	COG5002	protein histidine kinase activity
Y11_RS02920	COG1971	Probably functions as a manganese efflux pump
Y11_RS02925	COG4811	Protein of unknown function (DUF986)
Y11_RS02930	COG3716	PTS system mannose fructose sorbose family IID component
Y11_RS02935	COG3715	PTS system
Y11_RS02940	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Y11_RS02940	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
Y11_RS02945	COG1253	flavin adenine dinucleotide binding
Y11_RS02950	COG1760	l-serine dehydratase
Y11_RS02955	COG0494	nUDIX hydrolase
Y11_RS02965	COG3140	Belongs to the UPF0181 family
Y11_RS02970	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
Y11_RS02975	COG0513	Belongs to the DEAD box helicase family
Y11_RS02980	COG3141	response to X-ray
Y11_RS02985	COG3097	Belongs to the UPF0267 family
Y11_RS02995	COG1770	oligopeptidase
Y11_RS03000	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
Y11_RS03015	COG1528	Iron-storage protein
Y11_RS03020	COG2372	response to copper ion
Y11_RS03025	COG1276	copper resistance
Y11_RS03035	COG4974	Belongs to the 'phage' integrase family
Y11_RS03085	COG0500	methyltransferase
Y11_RS03090	COG3328	transposase activity
Y11_RS03100	COG0561	phosphatase activity
Y11_RS03105	COG2223	nitrite transmembrane transporter activity
Y11_RS03125	COG3493	citrate carrier protein
Y11_RS03130	COG4565	transcriptional regulatory protein
Y11_RS03135	COG3290	protein histidine kinase activity
Y11_RS03140	COG1349	DNA-binding transcription factor activity
Y11_RS03145	COG3395	kinase activity
Y11_RS03155	COG3622	Belongs to the hyi family
Y11_RS03160	COG2066	Belongs to the glutaminase family
Y11_RS03175	COG0672	)-iron permease
Y11_RS03200	COG0577	efflux transmembrane transporter activity
Y11_RS03200	COG1136	(ABC) transporter
Y11_RS03225	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Y11_RS03230	COG4114	ferric iron reductase
Y11_RS03235	COG0006	proline dipeptidase activity
Y11_RS03245	COG1649	PFAM Uncharacterised BCR, COG1649
Y11_RS03245	COG0726	polysaccharide deacetylase
Y11_RS03250	COG1215	transferase activity, transferring glycosyl groups
Y11_RS03255	COG3658	cytochrome
Y11_RS03270	COG1702	phosphate starvation-inducible protein PhoH
Y11_RS03280	COG0018	arginyl-trna synthetase
Y11_RS03285	COG3102	Protein conserved in bacteria
Y11_RS03290	COG3142	Participates in the control of copper homeostasis
Y11_RS03310	COG0668	transmembrane transport
Y11_RS03315	COG0625	glutathione transferase activity
Y11_RS03340	COG5001	Diguanylate cyclase
Y11_RS03375	COG2814	Major facilitator Superfamily
Y11_RS03385	COG3008	intermembrane lipid transfer
Y11_RS03390	COG2995	paraquat-inducible protein a
Y11_RS03395	COG1956	GAF domain-containing protein
Y11_RS03405	COG0793	Belongs to the peptidase S41A family
Y11_RS03410	COG0501	Belongs to the peptidase M48B family
Y11_RS03415	COG2814	Major facilitator Superfamily
Y11_RS03420	COG0823	Involved in the tonB-independent uptake of proteins
Y11_RS03430	COG3023	N-Acetylmuramoyl-L-alanine amidase
Y11_RS03445	COG1823	symporter activity
Y11_RS03450	COG1988	membrane-bound metal-dependent
Y11_RS03460	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
Y11_RS03465	COG1653	transport
Y11_RS03470	COG3842	ATPase activity
Y11_RS03475	COG0395	ABC-type sugar transport system, permease component
Y11_RS03480	COG1175	transmembrane transport
Y11_RS03490	COG1028	Short-chain dehydrogenase reductase Sdr
Y11_RS03495	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
Y11_RS03500	COG1917	Cupin 2, conserved barrel domain protein
Y11_RS03505	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Y11_RS03515	COG0583	DNA-binding transcription factor activity
Y11_RS03520	COG0427	acetyl-CoA hydrolase
Y11_RS03525	COG1024	Enoyl-CoA hydratase
Y11_RS03530	COG1703	isobutyryl-CoA mutase activity
Y11_RS03535	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Y11_RS03535	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Y11_RS03540	COG3001	Fructosamine kinase
Y11_RS03545	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Y11_RS03550	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Y11_RS03555	COG1121	(ABC) transporter
Y11_RS03560	COG0803	Belongs to the bacterial solute-binding protein 9 family
Y11_RS03595	COG1811	Na channel or pump
Y11_RS03600	COG4249	Peptidase C14 caspase catalytic subunit p20
Y11_RS03605	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Y11_RS03610	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
Y11_RS03615	COG0291	Belongs to the bacterial ribosomal protein bL35 family
Y11_RS03620	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
Y11_RS03625	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Y11_RS03635	COG0776	regulation of translation
Y11_RS03640	COG2314	TM2 domain
Y11_RS03650	COG4139	cobalamin transport
Y11_RS03655	COG0386	Belongs to the glutathione peroxidase family
Y11_RS03660	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
Y11_RS03665	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
Y11_RS03670	COG0463	Glycosyl transferase, family 2
Y11_RS03675	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Y11_RS03675	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Y11_RS03680	COG0726	polysaccharide deacetylase
Y11_RS03685	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
Y11_RS03690	COG2076	Multidrug Resistance protein
Y11_RS03695	COG2076	Multidrug Resistance protein
Y11_RS03700	COG0791	NLP P60 protein
Y11_RS03705	COG0095	Lipoate-protein ligase
Y11_RS03715	COG4558	Periplasmic binding protein
Y11_RS03720	COG3720	iron ion transport
Y11_RS03740	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
Y11_RS03745	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Y11_RS03745	COG0574	Belongs to the PEP-utilizing enzyme family
Y11_RS03750	COG0628	permease
Y11_RS03755	COG0277	FAD linked oxidase domain protein
Y11_RS03755	COG0247	lactate metabolic process
Y11_RS03760	COG2050	protein possibly involved in aromatic compounds catabolism
Y11_RS03770	COG0316	Belongs to the HesB IscA family
Y11_RS03775	COG0719	Fe-S assembly protein
Y11_RS03780	COG0396	ATPase activity
Y11_RS03785	COG0719	Fe-S assembly protein
Y11_RS03795	COG2166	iron-sulfur cluster assembly
Y11_RS03800	COG1376	ErfK ybiS ycfS ynhG family protein
Y11_RS03800	COG1388	LysM domain
Y11_RS03825	COG0534	Mate efflux family protein
Y11_RS03830	COG0307	riboflavin synthase, alpha
Y11_RS03835	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
Y11_RS03840	COG2814	Major facilitator Superfamily
Y11_RS03845	COG0583	DNA-binding transcription factor activity
Y11_RS03850	COG1609	Transcriptional regulator
Y11_RS03860	COG0791	NLP P60 protein
Y11_RS03865	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
Y11_RS03870	COG0346	lactoylglutathione lyase activity
Y11_RS03875	COG1902	pentaerythritol trinitrate reductase activity
Y11_RS03880	COG1309	transcriptional regulator
Y11_RS03885	COG2194	sulfuric ester hydrolase activity
Y11_RS03890	COG3313	Fe-S protein
Y11_RS03895	COG4989	oxidoreductase activity
Y11_RS03900	COG1289	transmembrane transporter activity
Y11_RS03905	COG1566	PFAM secretion protein HlyD family protein
Y11_RS03915	COG1846	Transcriptional regulator
Y11_RS03920	COG3133	Outer membrane lipoprotein
Y11_RS03925	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
Y11_RS03930	COG3895	Periplasmic Protein
Y11_RS03935	COG0259	pyridoxamine-phosphate oxidase activity
Y11_RS03940	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
Y11_RS03950	COG0625	glutathione transferase activity
Y11_RS03970	COG3104	oligopeptide transport
Y11_RS03980	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
Y11_RS03980	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
Y11_RS03990	COG4172	Belongs to the ABC transporter superfamily
Y11_RS04000	COG4171	peptide transport system, permease
Y11_RS04005	COG4168	peptide transport system, permease
Y11_RS04010	COG4166	transmembrane transport
Y11_RS04035	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
Y11_RS04040	COG1842	Phage shock protein A
Y11_RS04050	COG1983	PspC domain protein
Y11_RS04060	COG3106	COG3106 Predicted ATPase
Y11_RS04065	COG3768	UPF0283 membrane protein
Y11_RS04070	COG5654	RES domain protein
Y11_RS04080	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
Y11_RS04085	COG4948	Mandelate Racemase Muconate Lactonizing
Y11_RS04090	COG2866	Carboxypeptidase
Y11_RS04095	COG4166	transmembrane transport
Y11_RS04100	COG0598	Magnesium transport protein CorA
Y11_RS04105	COG0037	tRNA processing
Y11_RS04115	COG1013	pyruvate-flavodoxin oxidoreductase activity
Y11_RS04115	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Y11_RS04115	COG0674	pyruvate-flavodoxin oxidoreductase activity
Y11_RS04115	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Y11_RS04125	COG1285	pathogenesis
Y11_RS04130	COG3042	response to heat
Y11_RS04135	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Y11_RS04140	COG2911	Protein conserved in bacteria
Y11_RS04150	COG3784	Protein of unknown function (DUF1318)
Y11_RS04155	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
Y11_RS04160	COG1643	Atp-dependent helicase
Y11_RS04175	COG3591	Belongs to the peptidase S1B family
Y11_RS04185	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
Y11_RS04190	COG2205	protein histidine kinase activity
Y11_RS04195	COG0745	RESPONSE REGULATOR receiver
Y11_RS04205	COG0531	amino acid
Y11_RS04220	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
Y11_RS04225	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
Y11_RS04230	COG0589	response to stress
Y11_RS04235	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Y11_RS04240	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
Y11_RS04255	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
Y11_RS04260	COG1028	Short-chain dehydrogenase reductase Sdr
Y11_RS04270	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Y11_RS04285	COG1011	Hydrolase
Y11_RS04290	COG0440	acetolactate synthase activity
Y11_RS04295	COG0028	Belongs to the TPP enzyme family
Y11_RS04305	COG3023	N-Acetylmuramoyl-L-alanine amidase
Y11_RS04345	COG0483	inositol monophosphate 1-phosphatase activity
Y11_RS04365	COG3177	Filamentation induced by cAMP protein fic
Y11_RS04400	COG1522	sequence-specific DNA binding
Y11_RS04425	COG0625	glutathione transferase activity
Y11_RS04440	COG4128	Pfam Zonular occludens toxin
Y11_RS04545	COG4221	oxidoreductase activity
Y11_RS04550	COG1742	UPF0060 membrane protein
Y11_RS04580	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
Y11_RS04585	COG1940	carbohydrate kinase activity
Y11_RS04590	COG0583	DNA-binding transcription factor activity
Y11_RS04595	COG2814	Major facilitator Superfamily
Y11_RS04625	COG0114	fumarate hydratase activity
Y11_RS04635	COG5339	Protein conserved in bacteria
Y11_RS04645	COG1609	Transcriptional regulator
Y11_RS04650	COG1263	PTS System
Y11_RS04650	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Y11_RS04655	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
Y11_RS04660	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
Y11_RS04665	COG0385	Bile acid
Y11_RS04670	COG0673	inositol 2-dehydrogenase activity
Y11_RS04685	COG1129	ABC transporter
Y11_RS04690	COG1879	ABC-type sugar transport system periplasmic component
Y11_RS04700	COG2160	L-arabinose isomerase activity
Y11_RS04705	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
Y11_RS04710	COG2274	protein secretion by the type I secretion system
Y11_RS04720	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Y11_RS04730	COG2759	Belongs to the formate--tetrahydrofolate ligase family
Y11_RS04740	COG4657	Part of a membrane complex involved in electron transport
Y11_RS04750	COG4656	Part of a membrane complex involved in electron transport
Y11_RS04760	COG3708	Transcriptional regulator
Y11_RS04760	COG2207	Transcriptional regulator
Y11_RS04765	COG4658	electron transport chain
Y11_RS04770	COG4659	FMN binding
Y11_RS04780	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Y11_RS04805	COG0243	molybdopterin cofactor binding
Y11_RS04810	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
Y11_RS04815	COG1966	Carbon starvation protein
Y11_RS04820	COG2879	small protein
Y11_RS04825	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Y11_RS04830	COG1349	DNA-binding transcription factor activity
Y11_RS04855	COG0023	Translation Initiation Factor
Y11_RS04860	COG0284	orotidine-5'-phosphate decarboxylase activity
Y11_RS04875	COG1396	sequence-specific DNA binding
Y11_RS04885	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
Y11_RS04890	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
Y11_RS04895	COG0671	phosphoesterase, PA-phosphatase related
Y11_RS04920	COG0583	DNA-binding transcription factor activity
Y11_RS04935	COG0616	signal peptide processing
Y11_RS04940	COG1028	Short-chain dehydrogenase reductase Sdr
Y11_RS04945	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
Y11_RS04955	COG1187	pseudouridine synthase activity
Y11_RS04960	COG0009	L-threonylcarbamoyladenylate synthase
Y11_RS04965	COG0613	PHP domain protein
Y11_RS04975	COG0512	Glutamine amidotransferase of anthranilate synthase
Y11_RS04985	COG0135	phosphoribosylanthranilate isomerase activity
Y11_RS04985	COG0134	indole-3-glycerol-phosphate synthase activity
Y11_RS04990	COG0133	tryptophan synthase activity
Y11_RS04995	COG0159	tryptophan synthase activity
Y11_RS05005	COG3047	cAMP biosynthetic process
Y11_RS05010	COG0727	PFAM Uncharacterised protein family (UPF0153)
Y11_RS05025	COG2917	probably involved in intracellular septation
Y11_RS05030	COG1607	acyl-coa hydrolase
Y11_RS05035	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
Y11_RS05040	COG2350	Protein conserved in bacteria
Y11_RS05055	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Y11_RS05060	COG3099	Belongs to the UPF0263 family
Y11_RS05070	COG0444	Belongs to the ABC transporter superfamily
Y11_RS05075	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Y11_RS05095	COG2095	MarC family integral membrane protein
Y11_RS05100	COG1454	alcohol dehydrogenase
Y11_RS05100	COG1012	belongs to the aldehyde dehydrogenase family
Y11_RS05115	COG2916	Histone family protein nucleoid-structuring protein H-NS
Y11_RS05130	COG1752	Esterase of the alpha-beta hydrolase superfamily
Y11_RS05140	COG3012	SEC-C Motif Domain Protein
Y11_RS05145	COG0788	formyltetrahydrofolate deformylase activity
Y11_RS05160	COG0708	Exodeoxyribonuclease III
Y11_RS05165	COG0494	nUDIX hydrolase
Y11_RS05175	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Y11_RS05185	COG0778	Nitroreductase
Y11_RS05190	COG0616	signal peptide processing
Y11_RS05195	COG0252	asparaginase activity
Y11_RS05200	COG1335	isochorismatase
Y11_RS05215	COG3139	Protein of unknown function (DUF1315)
Y11_RS05220	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Y11_RS05235	COG3713	MltA-interacting MipA family protein
Y11_RS05240	COG2766	serine protein kinase
Y11_RS05245	COG2718	Belongs to the UPF0229 family
Y11_RS05260	COG0583	DNA-binding transcription factor activity
Y11_RS05270	COG2200	EAL domain
Y11_RS05270	COG2199	diguanylate cyclase activity
Y11_RS05270	COG2202	Pas domain
Y11_RS05275	COG2814	Major facilitator Superfamily
Y11_RS05280	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Y11_RS05285	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Y11_RS05290	COG2719	SpoVR family
Y11_RS05295	COG2186	Transcriptional regulator
Y11_RS05300	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
Y11_RS05305	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
Y11_RS05330	COG2983	Belongs to the UPF0260 family
Y11_RS05335	COG0179	Fumarylacetoacetate (FAA) hydrolase
Y11_RS05340	COG2951	lytic endotransglycosylase activity
Y11_RS05345	COG3100	YcgL domain-containing protein
Y11_RS05355	COG0850	regulation of cytokinetic process
Y11_RS05360	COG2894	cell division
Y11_RS05365	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
Y11_RS05370	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
Y11_RS05375	COG0318	PFAM AMP-dependent synthetase and ligase
Y11_RS05380	COG3065	identical protein binding
Y11_RS05390	COG1199	ATP-dependent helicase activity
Y11_RS05395	COG0251	oxidation-reduction process
Y11_RS05400	COG2076	Multidrug Resistance protein
Y11_RS05405	COG2076	Multidrug Resistance protein
Y11_RS05410	COG0800	Aldolase
Y11_RS05415	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
Y11_RS05420	COG1737	Transcriptional regulator
Y11_RS05425	COG0469	pyruvate kinase activity
Y11_RS05435	COG1560	Kdo2-lipid A biosynthetic process
Y11_RS05440	COG0739	heme binding
Y11_RS05445	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
Y11_RS05450	COG1121	(ABC) transporter
Y11_RS05455	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Y11_RS05460	COG3104	oligopeptide transport
Y11_RS05465	COG2255	four-way junction helicase activity
Y11_RS05470	COG0632	four-way junction helicase activity
Y11_RS05475	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
Y11_RS05480	COG0217	transcriptional regulatory protein
Y11_RS05485	COG0494	nUDIX hydrolase
Y11_RS05490	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
Y11_RS05500	COG1335	isochorismatase
Y11_RS05505	COG1801	Protein of unknown function DUF72
Y11_RS05510	COG3788	relative of glutathione S-transferase, MAPEG superfamily
Y11_RS05515	COG2226	methyltransferase
Y11_RS05520	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Y11_RS05535	COG1349	DNA-binding transcription factor activity
Y11_RS05545	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Y11_RS05555	COG3716	PTS system mannose fructose sorbose family IID component
Y11_RS05560	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
Y11_RS05565	COG2222	sugar isomerase
Y11_RS05575	COG4942	peptidase
Y11_RS05600	COG3443	Belongs to the bacterial solute-binding protein 9 family
Y11_RS05610	COG0402	S-adenosylhomocysteine deaminase activity
Y11_RS05620	COG1228	amidohydrolase
Y11_RS05650	COG2988	succinylglutamate desuccinylase activity
Y11_RS05665	COG3138	arginine N-succinyltransferase
Y11_RS05670	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Y11_RS05675	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Y11_RS05680	COG1271	oxidase subunit
Y11_RS05685	COG1294	oxidase, subunit
Y11_RS05690	COG3850	Histidine kinase
Y11_RS05695	COG0583	DNA-binding transcription factor activity
Y11_RS05705	COG2814	Major facilitator Superfamily
Y11_RS05715	COG0387	Pfam Sodium calcium exchanger
Y11_RS05720	COG0728	peptidoglycan biosynthetic process
Y11_RS05725	COG0673	inositol 2-dehydrogenase activity
Y11_RS05735	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Y11_RS05750	COG0477	Major facilitator Superfamily
Y11_RS05760	COG3381	protein complex oligomerization
Y11_RS05765	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
Y11_RS05770	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Y11_RS05790	COG3706	GGDEF domain
Y11_RS05795	COG0659	secondary active sulfate transmembrane transporter activity
Y11_RS05800	COG2877	3-deoxy-8-phosphooctulonate synthase activity
Y11_RS05815	COG2890	protein-(glutamine-N5) methyltransferase activity
Y11_RS05820	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
Y11_RS05825	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
Y11_RS05830	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
Y11_RS05840	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Y11_RS05855	COG0193	aminoacyl-tRNA hydrolase activity
Y11_RS05865	COG0012	GTP binding
Y11_RS05880	COG2979	Protein of unknown function (DUF533)
Y11_RS05885	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
Y11_RS05890	COG3772	lysozyme
Y11_RS05940	COG2963	transposase activity
Y11_RS06030	COG3041	Addiction module toxin RelE StbE family
Y11_RS06035	COG3077	Addiction module antitoxin, RelB DinJ family
Y11_RS06075	COG3328	transposase activity
Y11_RS06095	COG4974	Belongs to the 'phage' integrase family
Y11_RS06100	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Y11_RS06315	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Y11_RS06320	COG0322	excinuclease ABC activity
Y11_RS06325	COG2197	response regulator
Y11_RS06335	COG3136	membrane protein required for alginate biosynthesis
Y11_RS06345	COG0366	Alpha amylase catalytic
Y11_RS06360	COG2226	methyltransferase
Y11_RS06370	COG2963	transposase activity
Y11_RS06375	COG0582	viral genome integration into host DNA
Y11_RS06385	COG1113	amino acid transport
Y11_RS06390	COG1309	transcriptional regulator
Y11_RS06395	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Y11_RS06400	COG1335	isochorismatase
Y11_RS06405	COG0251	oxidation-reduction process
Y11_RS06410	COG2267	carboxylic ester hydrolase activity
Y11_RS06415	COG0778	Nitroreductase
Y11_RS06420	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Y11_RS06435	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
Y11_RS06445	COG0655	NAD(P)H dehydrogenase (quinone) activity
Y11_RS06455	COG2822	iron ion transport
Y11_RS06460	COG0672	)-iron permease
Y11_RS06470	COG3157	Type VI secretion system effector, Hcp
Y11_RS06490	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
Y11_RS06490	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
Y11_RS06490	COG0506	proline dehydrogenase activity
Y11_RS06505	COG1126	abc transporter atp-binding protein
Y11_RS06510	COG0765	amino acid transport
Y11_RS06515	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Y11_RS06520	COG2515	1-aminocyclopropane-1-carboxylate deaminase
Y11_RS06530	COG1191	sigma factor activity
Y11_RS06575	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Y11_RS06580	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
Y11_RS06610	COG0582	viral genome integration into host DNA
Y11_RS06615	COG1677	Flagellar hook-basal body complex protein FliE
Y11_RS06630	COG1317	bacterial-type flagellum organization
Y11_RS06650	COG1580	Controls the rotational direction of flagella during chemotaxis
Y11_RS06670	COG1338	Plays a role in the flagellum-specific transport system
Y11_RS06690	COG1256	bacterial-type flagellum assembly
Y11_RS06725	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
Y11_RS06730	COG1558	bacterial-type flagellum-dependent cell motility
Y11_RS06735	COG1815	bacterial-type flagellum-dependent cell motility
Y11_RS06745	COG2747	anti-sigma28 factor FlgM
Y11_RS06750	COG3418	PFAM FlgN family protein
Y11_RS06770	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Y11_RS06775	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Y11_RS06780	COG4935	Belongs to the peptidase S8 family
Y11_RS06780	COG1404	Belongs to the peptidase S8 family
Y11_RS06785	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
Y11_RS06790	COG0745	RESPONSE REGULATOR receiver
Y11_RS06800	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
Y11_RS06805	COG0840	transmembrane signaling receptor activity
Y11_RS06810	COG0840	transmembrane signaling receptor activity
Y11_RS06815	COG0835	chemotaxis
Y11_RS06820	COG2198	Histidine kinase
Y11_RS06820	COG0643	Histidine kinase
Y11_RS06825	COG1360	Flagellar Motor Protein
Y11_RS06845	COG0589	response to stress
Y11_RS06850	COG2130	NADP-dependent
Y11_RS06860	COG1285	pathogenesis
Y11_RS06875	COG0840	transmembrane signaling receptor activity
Y11_RS06890	COG1609	Transcriptional regulator
Y11_RS06895	COG3250	beta-galactosidase activity
Y11_RS06900	COG3328	transposase activity
Y11_RS06905	COG0604	alcohol dehydrogenase
Y11_RS06905	COG1028	Short-chain dehydrogenase reductase Sdr
Y11_RS06905	COG3321	synthase
Y11_RS06935	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
Y11_RS06945	COG3121	Chaperone
Y11_RS06970	COG1070	Carbohydrate kinase
Y11_RS06975	COG1070	Carbohydrate kinase
Y11_RS06985	COG3228	Belongs to the MtfA family
Y11_RS06995	COG0582	viral genome integration into host DNA
Y11_RS07000	COG0583	DNA-binding transcription factor activity
Y11_RS07005	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
Y11_RS07020	COG4227	nucleotidyltransferase activity
Y11_RS07070	COG2205	protein histidine kinase activity
Y11_RS07070	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Y11_RS07095	COG3121	Chaperone
Y11_RS07115	COG3122	Protein conserved in bacteria
Y11_RS07120	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
Y11_RS07120	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
Y11_RS07125	COG2814	Major facilitator Superfamily
Y11_RS07145	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Y11_RS07160	COG0471	metal ion transport
Y11_RS07170	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
Y11_RS07170	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
Y11_RS07175	COG3051	citrate lyase alpha subunit
Y11_RS07180	COG2301	Belongs to the HpcH HpaI aldolase family
Y11_RS07185	COG3052	prosthetic group binding
Y11_RS07190	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
Y11_RS07195	COG3290	protein histidine kinase activity
Y11_RS07200	COG4565	transcriptional regulatory protein
Y11_RS07215	COG2271	Major facilitator Superfamily
Y11_RS07220	COG1840	ABC-type Fe3 transport system, periplasmic component
Y11_RS07230	COG3842	ATPase activity
Y11_RS07260	COG0784	Response regulator, receiver
Y11_RS07260	COG0835	chemotaxis
Y11_RS07270	COG1349	DNA-binding transcription factor activity
Y11_RS07275	COG0561	phosphatase activity
Y11_RS07280	COG0352	thiamine-phosphate diphosphorylase activity
Y11_RS07290	COG0534	Mate efflux family protein
Y11_RS07295	COG0137	argininosuccinate synthase activity
Y11_RS07365	COG3188	usher protein
Y11_RS07370	COG3121	Chaperone
Y11_RS07430	COG2211	Major facilitator Superfamily
Y11_RS07440	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
Y11_RS07460	COG1492	cobalamin metabolic process
Y11_RS07525	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
Y11_RS07535	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
Y11_RS07610	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
Y11_RS07620	COG1012	belongs to the aldehyde dehydrogenase family
Y11_RS07630	COG4656	Part of a membrane complex involved in electron transport
Y11_RS07650	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
Y11_RS07660	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Y11_RS07675	COG1129	ABC transporter
Y11_RS07680	COG1172	Belongs to the binding-protein-dependent transport system permease family
Y11_RS07690	COG2926	Belongs to the UPF0265 family
Y11_RS07695	COG1289	transmembrane transporter activity
Y11_RS07700	COG1022	Amp-dependent synthetase and ligase
Y11_RS07700	COG3320	Male sterility
Y11_RS07705	COG2925	Exonuclease
Y11_RS07710	COG0531	amino acid
Y11_RS07720	COG0371	Dehydrogenase
Y11_RS07730	COG1172	Belongs to the binding-protein-dependent transport system permease family
Y11_RS07735	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Y11_RS07740	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
Y11_RS07750	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Y11_RS07755	COG0131	Imidazoleglycerol-phosphate dehydratase
Y11_RS07755	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
Y11_RS07765	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
Y11_RS07770	COG0107	imidazoleglycerol-phosphate synthase activity
Y11_RS07775	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
Y11_RS07775	COG0140	phosphoribosyl-ATP diphosphatase activity
Y11_RS07780	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
Y11_RS07790	COG1210	Utp--glucose-1-phosphate uridylyltransferase
Y11_RS07795	COG1210	Utp--glucose-1-phosphate uridylyltransferase
Y11_RS07840	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Y11_RS07880	COG1253	flavin adenine dinucleotide binding
Y11_RS07885	COG3069	C4-dicarboxylate transmembrane transporter activity
Y11_RS07890	COG2982	Protein involved in outer membrane biogenesis
Y11_RS07900	COG0572	uridine kinase
Y11_RS07905	COG0489	protein tyrosine kinase activity
Y11_RS07910	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Y11_RS07910	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Y11_RS07935	COG2814	Major facilitator Superfamily
Y11_RS07940	COG1380	Effector of murein hydrolase LrgA
Y11_RS07945	COG1346	cytolysis
Y11_RS07960	COG0281	malic enzyme
Y11_RS07965	COG2949	membrane
Y11_RS07970	COG0298	carbon dioxide binding
Y11_RS07975	COG0375	protein maturation
Y11_RS07980	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
Y11_RS07985	COG0651	ATP synthesis coupled electron transport
Y11_RS07990	COG0650	Formate hydrogenlyase subunit 4
Y11_RS07995	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Y11_RS08000	COG4237	Hydrogenase 4 membrane
Y11_RS08005	COG0651	ATP synthesis coupled electron transport
Y11_RS08010	COG3261	NADH dehydrogenase
Y11_RS08010	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
Y11_RS08015	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Y11_RS08020	COG3260	NADH ubiquinone oxidoreductase 20
Y11_RS08030	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
Y11_RS08035	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
Y11_RS08040	COG3383	formate dehydrogenase (NAD+) activity
Y11_RS08045	COG3604	Transcriptional regulator
Y11_RS08070	COG2311	Membrane
Y11_RS08075	COG0302	gtp cyclohydrolase
Y11_RS08080	COG0477	Major facilitator Superfamily
Y11_RS08085	COG0583	DNA-binding transcription factor activity
Y11_RS08115	COG1136	(ABC) transporter
Y11_RS08115	COG0577	efflux transmembrane transporter activity
Y11_RS08130	COG0303	'Molybdopterin
Y11_RS08135	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Y11_RS08145	COG0488	(ABC) transporter
Y11_RS08165	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
Y11_RS08185	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
Y11_RS08200	COG4106	trans-aconitate 2-methyltransferase activity
Y11_RS08205	COG0783	Belongs to the Dps family
Y11_RS08210	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
Y11_RS08215	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Y11_RS08220	COG0765	amino acid transport
Y11_RS08225	COG1126	abc transporter atp-binding protein
Y11_RS08235	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
Y11_RS08260	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Y11_RS08265	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
Y11_RS08285	COG0697	spore germination
Y11_RS08295	COG0583	DNA-binding transcription factor activity
Y11_RS08300	COG1028	Short-chain dehydrogenase reductase Sdr
Y11_RS08310	COG1174	glycine betaine transport
Y11_RS08315	COG1125	glycine betaine transport
Y11_RS08320	COG1174	glycine betaine transport
Y11_RS08325	COG1732	Glycine betaine
Y11_RS08340	COG2897	thiosulfate sulfurtransferase activity
Y11_RS08350	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
Y11_RS08370	COG4807	Protein conserved in bacteria
Y11_RS08385	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
Y11_RS08395	COG2261	transglycosylase associated protein
Y11_RS08415	COG0277	FAD linked oxidase domain protein
Y11_RS08420	COG1686	Belongs to the peptidase S11 family
Y11_RS08430	COG2239	Acts as a magnesium transporter
Y11_RS08440	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Y11_RS08445	COG0513	Belongs to the DEAD box helicase family
Y11_RS08450	COG1309	transcriptional regulator
Y11_RS08455	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Y11_RS08460	COG1131	(ABC) transporter
Y11_RS08465	COG0842	Transport permease protein
Y11_RS08470	COG0842	Transport permease protein
Y11_RS08475	COG0670	Belongs to the BI1 family
Y11_RS08480	COG0314	molybdopterin synthase activity
Y11_RS08485	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
Y11_RS08490	COG0315	cyclic pyranopterin monophosphate synthase activity
Y11_RS08495	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Y11_RS08500	COG0391	Required for morphogenesis under gluconeogenic growth conditions
Y11_RS08505	COG4628	conserved protein (DUF2132)
Y11_RS08510	COG0556	nucleotide-excision repair
Y11_RS08525	COG2226	methyltransferase
Y11_RS08530	COG0156	8-amino-7-oxononanoate synthase activity
Y11_RS08535	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Y11_RS08545	COG2706	6-phosphogluconolactonase activity
Y11_RS08550	COG0561	phosphatase activity
Y11_RS08560	COG4149	molybdate abc transporter
Y11_RS08575	COG2005	Transcriptional regulator
Y11_RS08575	COG3585	molybdate ion transport
Y11_RS08580	COG1119	ATPase activity
Y11_RS08590	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Y11_RS08595	COG1085	galactose-1-phosphate uridylyltransferase
Y11_RS08600	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
Y11_RS08605	COG2017	converts alpha-aldose to the beta-anomer
Y11_RS08625	COG0588	phosphoglycerate mutase activity
Y11_RS08630	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
Y11_RS08635	COG1230	cation diffusion facilitator family transporter
Y11_RS08645	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
Y11_RS08655	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
Y11_RS08660	COG2885	chlorophyll binding
Y11_RS08665	COG0823	Involved in the tonB-independent uptake of proteins
Y11_RS08670	COG3064	Membrane
Y11_RS08670	COG3064	Membrane
Y11_RS08675	COG0848	biopolymer transport protein
Y11_RS08680	COG0811	peptide transport
Y11_RS08685	COG0824	Thioesterase
Y11_RS08690	COG3790	cyd operon protein YbgE
Y11_RS08695	COG4890	Cyd operon protein YbgT
Y11_RS08700	COG1294	oxidase, subunit
Y11_RS08705	COG1271	oxidase subunit
Y11_RS08710	COG0737	Belongs to the 5'-nucleotidase family
Y11_RS08715	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
Y11_RS08720	COG0045	succinate-CoA ligase (ADP-forming) activity
Y11_RS08725	COG0508	dehydrogenase complex catalyzes the overall conversion of
Y11_RS08730	COG0567	Dehydrogenase, E1 component
Y11_RS08740	COG1053	succinate dehydrogenase
Y11_RS08745	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
Y11_RS08750	COG2009	succinate dehydrogenase
Y11_RS08760	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
Y11_RS08775	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
Y11_RS08780	COG1984	allophanate hydrolase subunit 2
Y11_RS08790	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
Y11_RS08795	COG5212	phosphodiesterase
Y11_RS08805	COG3272	Protein of unknown function (DUF1722)
Y11_RS08810	COG1073	alpha beta
Y11_RS08810	COG1073	alpha beta
Y11_RS08810	COG3064	Membrane
Y11_RS08810	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
Y11_RS08810	COG3064	Membrane
Y11_RS08810	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
Y11_RS08815	COG2994	toxin metabolic process
Y11_RS08835	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
Y11_RS08840	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
Y11_RS08845	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
Y11_RS08850	COG2205	protein histidine kinase activity
Y11_RS08855	COG0745	RESPONSE REGULATOR receiver
Y11_RS08870	COG0033	Phosphoglucomutase
Y11_RS08875	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
Y11_RS08880	COG0596	Alpha beta hydrolase
Y11_RS08890	COG0840	transmembrane signaling receptor activity
Y11_RS08900	COG0735	belongs to the Fur family
Y11_RS08920	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Y11_RS08925	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Y11_RS08925	COG2190	(PTS) system
Y11_RS08925	COG1263	PTS System
Y11_RS08930	COG0363	glucosamine-6-phosphate deaminase activity
Y11_RS08935	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
Y11_RS08940	COG1846	Transcriptional regulator
Y11_RS08940	COG1940	carbohydrate kinase activity
Y11_RS08945	COG0647	UMP catabolic process
Y11_RS08950	COG0367	asparagine synthase
Y11_RS08985	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Y11_RS08990	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Y11_RS08995	COG1702	phosphate starvation-inducible protein PhoH
Y11_RS09000	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
Y11_RS09005	COG4535	Mg2 and Co2 transporter CorC
Y11_RS09010	COG0815	Transfers the fatty acyl group on membrane lipoproteins
Y11_RS09025	COG0765	amino acid transport
Y11_RS09030	COG0765	amino acid transport
Y11_RS09035	COG1126	abc transporter atp-binding protein
Y11_RS09040	COG2888	peptidyl-tyrosine sulfation
Y11_RS09045	COG0495	leucyl-tRNA aminoacylation
Y11_RS09050	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
Y11_RS09055	COG1466	dna polymerase III delta subunit
Y11_RS09060	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
Y11_RS09065	COG0799	negative regulation of ribosome biogenesis
Y11_RS09075	COG0768	penicillin binding
Y11_RS09080	COG0772	Belongs to the SEDS family
Y11_RS09085	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
Y11_RS09090	COG1686	Belongs to the peptidase S11 family
Y11_RS09095	COG2921	Belongs to the UPF0250 family
Y11_RS09100	COG0321	lipoyl(octanoyl) transferase activity
Y11_RS09105	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
Y11_RS09110	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Y11_RS09115	COG3706	GGDEF domain
Y11_RS09130	COG1278	Cold shock
Y11_RS09135	COG2197	response regulator
Y11_RS09145	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
Y11_RS09160	COG5265	(ABC) transporter
Y11_RS09170	COG2986	histidine ammonia-lyase
Y11_RS09175	COG2850	peptidyl-arginine hydroxylation
Y11_RS09185	COG0582	viral genome integration into host DNA
Y11_RS09255	COG0582	viral genome integration into host DNA
Y11_RS09265	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Y11_RS09270	COG2501	S4 domain
Y11_RS09275	COG0215	cysteine-tRNA ligase activity
Y11_RS09280	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Y11_RS09285	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Y11_RS09290	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
Y11_RS09295	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
Y11_RS09305	COG4181	ATPase activity
Y11_RS09310	COG2755	lipolytic protein G-D-S-L family
Y11_RS09315	COG0300	oxidoreductase activity
Y11_RS09320	COG3118	belongs to the thioredoxin family
Y11_RS09325	COG0330	HflC and HflK could
Y11_RS09330	COG1585	Membrane protein implicated in regulation of membrane protease activity
Y11_RS09335	COG0789	Transcriptional regulator
Y11_RS09340	COG2217	Heavy metal translocating P-type atpase
Y11_RS09345	COG3735	TraB family
Y11_RS09350	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
Y11_RS09360	COG0737	Belongs to the 5'-nucleotidase family
Y11_RS09365	COG2223	nitrite transmembrane transporter activity
Y11_RS09370	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
Y11_RS09370	COG4651	solute:proton antiporter activity
Y11_RS09375	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Y11_RS09395	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Y11_RS09400	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Y11_RS09405	COG0438	transferase activity, transferring glycosyl groups
Y11_RS09410	COG1215	transferase activity, transferring glycosyl groups
Y11_RS09415	COG1216	Glycosyl transferase, family 2
Y11_RS09415	COG1442	glycosyl transferase family 8
Y11_RS09420	COG2244	polysaccharide biosynthetic process
Y11_RS09425	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
Y11_RS09430	COG0563	adenylate kinase activity
Y11_RS09435	COG0326	Molecular chaperone. Has ATPase activity
Y11_RS09440	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
Y11_RS09445	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
Y11_RS09455	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Y11_RS09460	COG2832	Protein of unknown function (DUF454)
Y11_RS09475	COG1196	nuclear chromosome segregation
Y11_RS09475	COG3264	Mechanosensitive ion channel
Y11_RS09480	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
Y11_RS09485	COG1309	transcriptional regulator
Y11_RS09490	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Y11_RS09495	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Y11_RS09510	COG3457	Alanine racemase
Y11_RS09515	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
Y11_RS09530	COG0254	rRNA binding
Y11_RS09535	COG0257	Belongs to the bacterial ribosomal protein bL36 family
Y11_RS09540	COG0803	Belongs to the bacterial solute-binding protein 9 family
Y11_RS09545	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Y11_RS09570	COG3695	enzyme binding
Y11_RS09575	COG3126	Type III secretion system lipoprotein chaperone (YscW)
Y11_RS09580	COG1946	Acyl-CoA thioesterase
Y11_RS09585	COG0004	ammonium transporteR
Y11_RS09590	COG0347	Belongs to the P(II) protein family
Y11_RS09595	COG1132	(ABC) transporter
Y11_RS09600	COG1132	(ABC) transporter
Y11_RS09605	COG1522	sequence-specific DNA binding
Y11_RS09615	COG0561	phosphatase activity
Y11_RS09620	COG4533	DNA binding
Y11_RS09625	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
Y11_RS09630	COG0824	Thioesterase
Y11_RS09635	COG1555	photosystem II stabilization
Y11_RS09640	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Y11_RS09645	COG0776	regulation of translation
Y11_RS09650	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Y11_RS09655	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
Y11_RS09660	COG0740	serine-type endopeptidase activity
Y11_RS09665	COG0544	peptidyl-prolyl cis-trans isomerase activity
Y11_RS09670	COG0271	Belongs to the BolA IbaG family
Y11_RS09675	COG3056	Lipoprotein
Y11_RS09680	COG2223	nitrite transmembrane transporter activity
Y11_RS09690	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
Y11_RS09695	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
Y11_RS09700	COG1845	cytochrome c oxidase, subunit III
Y11_RS09705	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
Y11_RS09710	COG0109	protoheme IX farnesyltransferase activity
Y11_RS09715	COG2814	Major facilitator Superfamily
Y11_RS09720	COG1666	GTP binding
Y11_RS09725	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
Y11_RS09735	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Y11_RS09735	COG0301	tRNA thio-modification
Y11_RS09745	COG0142	geranyltranstransferase activity
Y11_RS09750	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Y11_RS09760	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
Y11_RS09765	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
Y11_RS09770	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Y11_RS09775	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
Y11_RS09780	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Y11_RS09780	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Y11_RS09785	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Y11_RS09805	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Y11_RS09810	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Y11_RS09815	COG1862	Preprotein translocase
Y11_RS09820	COG0343	queuine tRNA-ribosyltransferase activity
Y11_RS09835	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
Y11_RS09840	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
Y11_RS09845	COG0450	alkyl hydroperoxide reductase
Y11_RS09865	COG0366	Alpha amylase catalytic
Y11_RS09885	COG5002	protein histidine kinase activity
Y11_RS09890	COG0745	RESPONSE REGULATOR receiver
Y11_RS09895	COG0420	3'-5' exonuclease activity
Y11_RS09900	COG0419	ATPase involved in DNA repair
Y11_RS09905	COG1940	carbohydrate kinase activity
Y11_RS09910	COG2974	May be involved in recombination
Y11_RS09915	COG3123	guanosine phosphorylase activity
Y11_RS09920	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Y11_RS09945	COG2226	methyltransferase
Y11_RS09960	COG3459	Glycosyltransferase 36 associated
Y11_RS09980	COG2188	Transcriptional regulator
Y11_RS09985	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
Y11_RS09990	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
Y11_RS10000	COG1073	alpha beta
Y11_RS10005	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
Y11_RS10010	COG2195	Cleaves the N-terminal amino acid of tripeptides
Y11_RS10015	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Y11_RS10030	COG2964	Protein conserved in bacteria
Y11_RS10035	COG1181	Belongs to the D-alanine--D-alanine ligase family
Y11_RS10045	COG2991	Protein conserved in bacteria
Y11_RS10050	COG1477	protein flavinylation
Y11_RS10055	COG2871	sodium ion transport
Y11_RS10060	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
Y11_RS10065	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
Y11_RS10070	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
Y11_RS10075	COG1805	sodium ion transport
Y11_RS10080	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
Y11_RS10085	COG3034	peptidoglycan biosynthetic process
Y11_RS10090	COG0121	glutamine amidotransferase
Y11_RS10100	COG1960	acyl-CoA dehydrogenase activity
Y11_RS10105	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
Y11_RS10125	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
Y11_RS10130	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
Y11_RS10135	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
Y11_RS10140	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
Y11_RS10145	COG0235	Class ii aldolase
Y11_RS10150	COG0436	Aminotransferase
Y11_RS10165	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
Y11_RS10175	COG0765	amino acid transport
Y11_RS10180	COG0765	amino acid transport
Y11_RS10215	COG2814	Major facilitator Superfamily
Y11_RS10220	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
Y11_RS10230	COG1846	Transcriptional regulator
Y11_RS10235	COG1538	Outer membrane efflux protein
Y11_RS10240	COG1566	PFAM secretion protein HlyD family protein
Y11_RS10245	COG2814	Major facilitator Superfamily
Y11_RS10260	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Y11_RS10265	COG3118	belongs to the thioredoxin family
Y11_RS10270	COG3148	PFAM DTW domain containing protein
Y11_RS10275	COG0045	succinate-CoA ligase (ADP-forming) activity
Y11_RS10275	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Y11_RS10275	COG1042	CoA-binding domain protein
Y11_RS10280	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Y11_RS10285	COG5544	Lipoprotein
Y11_RS10310	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
Y11_RS10315	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Y11_RS10320	COG0564	pseudouridine synthase activity
Y11_RS10330	COG0542	response to heat
Y11_RS10345	COG0077	Prephenate dehydratase
Y11_RS10345	COG1605	Chorismate mutase
Y11_RS10350	COG1605	Chorismate mutase
Y11_RS10350	COG0287	Prephenate dehydrogenase
Y11_RS10355	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
Y11_RS10360	COG3279	Response regulator of the LytR AlgR family
Y11_RS10365	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
Y11_RS10370	COG3137	Salt-induced outer membrane protein
Y11_RS10375	COG0335	large ribosomal subunit rRNA binding
Y11_RS10380	COG0336	Belongs to the RNA methyltransferase TrmD family
Y11_RS10385	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
Y11_RS10390	COG0228	four-way junction DNA binding
Y11_RS10395	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Y11_RS10400	COG4137	Cytochrome C assembly protein
Y11_RS10405	COG4536	flavin adenine dinucleotide binding
Y11_RS10410	COG1854	S-ribosylhomocysteine lyase activity
Y11_RS10415	COG2918	glutathione biosynthetic process
Y11_RS10420	COG1238	metal cluster binding
Y11_RS10425	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Y11_RS10445	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
Y11_RS10450	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Y11_RS10455	COG2137	regulation of response to DNA damage stimulus
Y11_RS10460	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Y11_RS10480	COG3381	protein complex oligomerization
Y11_RS10485	COG3302	dmso reductase anchor subunit
Y11_RS10490	COG0437	4 iron, 4 sulfur cluster binding
Y11_RS10495	COG0243	molybdopterin cofactor binding
Y11_RS10500	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
Y11_RS10500	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
Y11_RS10515	COG4177	L-phenylalanine transmembrane transporter activity
Y11_RS10520	COG1137	ATPase activity
Y11_RS10525	COG0410	ABC transporter
Y11_RS10580	COG0640	Transcriptional regulator
Y11_RS10585	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Y11_RS10595	COG1858	cytochrome C peroxidase
Y11_RS10600	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Y11_RS10610	COG1028	Short-chain dehydrogenase reductase Sdr
Y11_RS10630	COG1538	Outer membrane efflux protein
Y11_RS10640	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Y11_RS10670	COG3539	Fimbrial protein
Y11_RS10675	COG3539	Fimbrial protein
Y11_RS10685	COG3121	Chaperone
Y11_RS10690	COG3188	usher protein
Y11_RS10715	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
Y11_RS10720	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Y11_RS10725	COG1388	LysM domain
Y11_RS10725	COG4942	peptidase
Y11_RS10730	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Y11_RS10735	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
Y11_RS10740	COG0585	pseudouridine synthase activity
Y11_RS10745	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Y11_RS10755	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
Y11_RS10765	COG0529	Catalyzes the synthesis of activated sulfate
Y11_RS10770	COG2895	sulfate adenylyltransferase (ATP) activity
Y11_RS10775	COG0175	sulfate reduction
Y11_RS10780	COG1648	precorrin-2 dehydrogenase activity
Y11_RS10780	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Y11_RS10785	COG2234	aminopeptidase activity
Y11_RS10800	COG0175	sulfate reduction
Y11_RS10805	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Y11_RS10810	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
Y11_RS10815	COG0720	synthase
Y11_RS10835	COG0602	queuosine metabolic process
Y11_RS10865	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Y11_RS10870	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
Y11_RS10875	COG0583	DNA-binding transcription factor activity
Y11_RS10885	COG1279	arginine transmembrane transporter activity
Y11_RS10905	COG0191	fructose-bisphosphate aldolase activity
Y11_RS10910	COG0126	phosphoglycerate kinase activity
Y11_RS10915	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
Y11_RS10920	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
Y11_RS10925	COG0501	Belongs to the peptidase M48B family
Y11_RS10935	COG1166	arginine decarboxylase activity
Y11_RS10940	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Y11_RS10955	COG0640	Transcriptional regulator
Y11_RS10960	COG3091	SprT-like family
Y11_RS10965	COG2356	endonuclease I
Y11_RS10970	COG1385	rRNA (uridine-N3-)-methyltransferase activity
Y11_RS10975	COG0189	ligase activity
Y11_RS10980	COG1678	Uncharacterized ACR, COG1678
Y11_RS10985	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
Y11_RS10990	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Y11_RS11000	COG2805	Type II/IV secretion system protein
Y11_RS11005	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
Y11_RS11010	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
Y11_RS11015	COG0762	integral membrane protein
Y11_RS11020	COG1872	DUF167
Y11_RS11025	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Y11_RS11030	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Y11_RS11045	COG3171	Protein conserved in bacteria
Y11_RS11050	COG0220	tRNA (guanine-N7-)-methyltransferase activity
Y11_RS11055	COG1194	a g-specific adenine glycosylase
Y11_RS11060	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
Y11_RS11065	COG0741	lytic transglycosylase activity
Y11_RS11075	COG1982	Orn Lys Arg decarboxylase major
Y11_RS11090	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
Y11_RS11135	COG0531	amino acid
Y11_RS11140	COG1982	Orn Lys Arg decarboxylase major
Y11_RS11150	COG1289	transmembrane transporter activity
Y11_RS11175	COG0024	Methionine aminopeptidase
Y11_RS11180	COG4604	ABC transporter, ATP-binding protein
Y11_RS11185	COG4605	iron ion homeostasis
Y11_RS11195	COG4607	ABC-type enterochelin transport system periplasmic component
Y11_RS11210	COG0697	spore germination
Y11_RS11215	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Y11_RS11225	COG0477	Major facilitator Superfamily
Y11_RS11230	COG1609	Transcriptional regulator
Y11_RS11240	COG1283	sodium-dependent phosphate transmembrane transporter activity
Y11_RS11255	COG0477	Major facilitator Superfamily
Y11_RS11275	COG5001	Diguanylate cyclase
Y11_RS11290	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
Y11_RS11300	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
Y11_RS11305	COG0309	Hydrogenase expression formation protein (HypE)
Y11_RS11310	COG0409	Hydrogenase expression formation protein
Y11_RS11315	COG0298	carbon dioxide binding
Y11_RS11320	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
Y11_RS11330	COG1773	rubredoxin
Y11_RS11335	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
Y11_RS11340	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
Y11_RS11345	COG5557	Pfam Polysulphide reductase, NrfD
Y11_RS11350	COG0437	4 iron, 4 sulfur cluster binding
Y11_RS11355	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
Y11_RS11360	COG3133	Outer membrane lipoprotein
Y11_RS11370	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
Y11_RS11375	COG1191	sigma factor activity
Y11_RS11395	COG1516	flagellar protein fliS
Y11_RS11400	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
Y11_RS11405	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Y11_RS11410	COG3710	Transcriptional regulator
Y11_RS11455	COG4786	Flagellar basal body rod
Y11_RS11470	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
Y11_RS11475	COG1558	bacterial-type flagellum-dependent cell motility
Y11_RS11480	COG1815	bacterial-type flagellum-dependent cell motility
Y11_RS11510	COG2801	Transposase and inactivated derivatives
Y11_RS11525	COG0577	efflux transmembrane transporter activity
Y11_RS11525	COG1136	(ABC) transporter
Y11_RS11545	COG2963	transposase activity
Y11_RS11560	COG2135	peptidase activity
Y11_RS11565	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Y11_RS11595	COG4964	Belongs to the GSP D family
Y11_RS11645	COG0848	biopolymer transport protein
Y11_RS11655	COG0626	cystathionine gamma-synthase activity
Y11_RS11660	COG0586	Pfam SNARE associated Golgi protein
Y11_RS11665	COG2207	Transcriptional regulator
Y11_RS11670	COG1979	alcohol dehydrogenase
Y11_RS11675	COG0656	L-ascorbic acid biosynthetic process
Y11_RS11685	COG2132	Multicopper oxidase
Y11_RS11695	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Y11_RS11700	COG2249	NAD(P)H dehydrogenase (quinone) activity
Y11_RS11705	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
Y11_RS11720	COG3150	esterase
Y11_RS11725	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
Y11_RS11730	COG3151	Protein conserved in bacteria
Y11_RS11735	COG0494	nUDIX hydrolase
Y11_RS11740	COG1538	Outer membrane efflux protein
Y11_RS11745	COG5463	Belongs to the UPF0441 family
Y11_RS11750	COG0754	glutathionylspermidine amidase activity
Y11_RS11755	COG3384	dioxygenase
Y11_RS11760	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Y11_RS11770	COG0531	amino acid
Y11_RS11775	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
Y11_RS11775	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
Y11_RS11780	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
Y11_RS11785	COG3025	triphosphatase activity
Y11_RS11790	COG4991	sh3 domain protein
Y11_RS11795	COG0617	tRNA 3'-terminal CCA addition
Y11_RS11800	COG1968	undecaprenyl-diphosphatase activity
Y11_RS11805	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
Y11_RS11810	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
Y11_RS11815	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Y11_RS11820	COG0828	Belongs to the bacterial ribosomal protein bS21 family
Y11_RS11825	COG0358	DNA primase activity
Y11_RS11985	COG4695	Portal protein
Y11_RS12040	COG4974	Belongs to the 'phage' integrase family
Y11_RS12045	COG3876	Protein conserved in bacteria
Y11_RS12055	COG1472	Belongs to the glycosyl hydrolase 3 family
Y11_RS12065	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
Y11_RS12070	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Y11_RS12070	COG1263	PTS System
Y11_RS12080	COG0531	amino acid
Y11_RS12095	COG3247	response to pH
Y11_RS12105	COG0446	pyridine nucleotide-disulphide oxidoreductase
Y11_RS12105	COG1902	pentaerythritol trinitrate reductase activity
Y11_RS12120	COG2813	Specifically methylates the guanine in position
Y11_RS12140	COG1451	nucleotide metabolic process
Y11_RS12145	COG0673	inositol 2-dehydrogenase activity
Y11_RS12155	COG0861	Integral membrane protein TerC family
Y11_RS12160	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
Y11_RS12170	COG2721	sulfolactate sulfo-lyase activity
Y11_RS12175	COG0246	Mannitol dehydrogenase
Y11_RS12180	COG1904	glucuronate isomerase
Y11_RS12185	COG2271	Major facilitator Superfamily
Y11_RS12200	COG0586	Pfam SNARE associated Golgi protein
Y11_RS12215	COG4575	ribosome binding
Y11_RS12220	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
Y11_RS12230	COG2259	Doxx family
Y11_RS12235	COG0435	Glutathione S-transferase
Y11_RS12240	COG0583	DNA-binding transcription factor activity
Y11_RS12245	COG1741	Belongs to the pirin family
Y11_RS12255	COG0667	Aldo Keto reductase
Y11_RS12275	COG3121	Chaperone
Y11_RS12320	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
Y11_RS12330	COG0792	nuclease activity
Y11_RS12335	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
Y11_RS12340	COG2823	Periplasmic or secreted lipoprotein
Y11_RS12350	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Y11_RS12355	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
Y11_RS12360	COG0784	Response regulator, receiver
Y11_RS12360	COG5002	protein histidine kinase activity
Y11_RS12360	COG2198	Histidine kinase
Y11_RS12365	COG1242	4 iron, 4 sulfur cluster binding
Y11_RS12370	COG0070	glutamate synthase
Y11_RS12370	COG0069	glutamate synthase activity
Y11_RS12370	COG0067	glutamate synthase
Y11_RS12375	COG0493	'glutamate synthase
Y11_RS12390	COG2969	positive regulation of protein catabolic process
Y11_RS12395	COG0625	glutathione transferase activity
Y11_RS12400	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Y11_RS12405	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Y11_RS12410	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
Y11_RS12415	COG3105	Protein conserved in bacteria
Y11_RS12420	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Y11_RS12425	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Y11_RS12430	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Y11_RS12435	COG5007	Belongs to the BolA IbaG family
Y11_RS12440	COG3113	response to antibiotic
Y11_RS12445	COG2854	intermembrane phospholipid transfer
Y11_RS12450	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
Y11_RS12455	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
Y11_RS12460	COG1127	ABC transporter
Y11_RS12465	COG0530	calcium, potassium:sodium antiporter activity
Y11_RS12470	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
Y11_RS12470	COG0517	IMP dehydrogenase activity
Y11_RS12475	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
Y11_RS12480	COG3117	lipopolysaccharide transmembrane transporter activity
Y11_RS12485	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
Y11_RS12490	COG1137	ATPase activity
Y11_RS12495	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
Y11_RS12510	COG1660	Displays ATPase and GTPase activities
Y11_RS12515	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
Y11_RS12520	COG0540	Belongs to the ATCase OTCase family
Y11_RS12525	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
Y11_RS12535	COG2308	Evidence 4 Homologs of previously reported genes of
Y11_RS12555	COG0366	Alpha amylase catalytic
Y11_RS12560	COG1263	PTS System
Y11_RS12560	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Y11_RS12570	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Y11_RS12580	COG3093	addiction module antidote protein HigA
Y11_RS12585	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Y11_RS12585	COG3711	transcriptional antiterminator
Y11_RS12590	COG2706	6-phosphogluconolactonase activity
Y11_RS12605	COG3964	amidohydrolase
Y11_RS12635	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Y11_RS12640	COG3783	Cytochrome b(562)
Y11_RS12650	COG0312	modulator of DNA gyrase
Y11_RS12655	COG3028	Belongs to the UPF0307 family
Y11_RS12660	COG2732	(Barnase) inhibitor
Y11_RS12675	COG1289	transmembrane transporter activity
Y11_RS12680	COG1566	PFAM secretion protein HlyD family protein
Y11_RS12690	COG0583	DNA-binding transcription factor activity
Y11_RS12755	COG0312	modulator of DNA gyrase
Y11_RS12760	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Y11_RS12765	COG3164	Protein of unknown function
Y11_RS12775	COG0424	maF-like protein
Y11_RS12780	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
Y11_RS12785	COG1792	Involved in formation and maintenance of cell shape
Y11_RS12790	COG1077	Cell shape determining protein MreB Mrl
Y11_RS12795	COG2200	EAL domain
Y11_RS12795	COG2199	diguanylate cyclase activity
Y11_RS12800	COG0604	alcohol dehydrogenase
Y11_RS12810	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
Y11_RS12815	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
Y11_RS12820	COG0511	ligase activity, forming carbon-carbon bonds
Y11_RS12825	COG0439	Biotin carboxylase
Y11_RS12830	COG3924	membrane
Y11_RS12835	COG4145	pantothenate transmembrane transporter activity
Y11_RS12840	COG2264	protein methyltransferase activity
Y11_RS12845	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Y11_RS12850	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
Y11_RS12860	COG3133	Outer membrane lipoprotein
Y11_RS12865	COG1278	Cold shock
Y11_RS12870	COG1278	Cold shock
Y11_RS12875	COG0471	metal ion transport
Y11_RS12880	COG1560	Kdo2-lipid A biosynthetic process
Y11_RS12895	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Y11_RS12900	COG4597	amino acid ABC transporter
Y11_RS12905	COG0765	amino acid transport
Y11_RS12910	COG1126	abc transporter atp-binding protein
Y11_RS12920	COG1380	Effector of murein hydrolase LrgA
Y11_RS12925	COG0583	DNA-binding transcription factor activity
Y11_RS12930	COG0025	NhaP-type Na H and K H
Y11_RS12935	COG2252	PERMEase
Y11_RS12950	COG3550	peptidyl-serine autophosphorylation
Y11_RS12960	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
Y11_RS12965	COG2315	Protein conserved in bacteria
Y11_RS12970	COG1448	Aminotransferase
Y11_RS13000	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Y11_RS13010	COG0735	belongs to the Fur family
Y11_RS13015	COG3237	CsbD-like
Y11_RS13020	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Y11_RS13025	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
Y11_RS13030	COG2937	Belongs to the GPAT DAPAT family
Y11_RS13035	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
Y11_RS13040	COG3161	chorismate lyase activity
Y11_RS13055	COG4580	involved in the transport of maltose and maltodextrins
Y11_RS13065	COG2182	Extracellular solute-binding protein
Y11_RS13070	COG1175	transmembrane transport
Y11_RS13075	COG3833	ABC-type maltose transport systems, permease component
Y11_RS13085	COG0166	Belongs to the GPI family
Y11_RS13090	COG0527	aspartate kinase activity
Y11_RS13115	COG1414	Transcriptional regulator
Y11_RS13120	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
Y11_RS13125	COG2224	Isocitrate lyase
Y11_RS13130	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
Y11_RS13135	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
Y11_RS13170	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
Y11_RS13180	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Y11_RS13190	COG1309	transcriptional regulator
Y11_RS13195	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Y11_RS13205	COG0678	peroxiredoxin activity
Y11_RS13205	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
Y11_RS13210	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Y11_RS13250	COG1629	transport
Y11_RS13255	COG0165	Argininosuccinate lyase
Y11_RS13260	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Y11_RS13275	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
Y11_RS13285	COG0460	homoserine dehydrogenase
Y11_RS13285	COG0527	aspartate kinase activity
Y11_RS13290	COG0626	cystathionine gamma-synthase activity
Y11_RS13295	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
Y11_RS13300	COG0254	rRNA binding
Y11_RS13305	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
Y11_RS13310	COG1609	Transcriptional regulator
Y11_RS13315	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
Y11_RS13320	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
Y11_RS13325	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
Y11_RS13330	COG1575	Belongs to the MenA family. Type 1 subfamily
Y11_RS13335	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
Y11_RS13340	COG3074	FtsZ-dependent cytokinesis
Y11_RS13350	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
Y11_RS13360	COG1494	fructose-1,6-bisphosphatase
Y11_RS13370	COG2814	Major facilitator Superfamily
Y11_RS13390	COG3152	Membrane
Y11_RS13400	COG0149	triose-phosphate isomerase activity
Y11_RS13410	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
Y11_RS13420	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
Y11_RS13505	COG4695	Portal protein
Y11_RS13525	COG0653	protein targeting
Y11_RS13550	COG4974	Belongs to the 'phage' integrase family
Y11_RS13555	COG3678	ATP-independent chaperone mediated protein folding
Y11_RS13560	COG0745	RESPONSE REGULATOR receiver
Y11_RS13565	COG2205	protein histidine kinase activity
Y11_RS13570	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
Y11_RS13570	COG2169	Transcriptional regulator
Y11_RS13575	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
Y11_RS13580	COG1045	serine acetyltransferase
Y11_RS13585	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Y11_RS13590	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
Y11_RS13595	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
Y11_RS13600	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Y11_RS13605	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
Y11_RS13610	COG4942	peptidase
Y11_RS13615	COG2861	carbohydrate metabolic process
Y11_RS13630	COG1063	alcohol dehydrogenase
Y11_RS13635	COG0156	8-amino-7-oxononanoate synthase activity
Y11_RS13640	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Y11_RS13645	COG0859	PFAM glycosyl transferase family 9
Y11_RS13650	COG0859	PFAM glycosyl transferase family 9
Y11_RS13655	COG1519	Transferase
Y11_RS13665	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Y11_RS13670	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Y11_RS13675	COG0267	Belongs to the bacterial ribosomal protein bL33 family
Y11_RS13680	COG0227	Belongs to the bacterial ribosomal protein bL28 family
Y11_RS13685	COG2003	Belongs to the UPF0758 family
Y11_RS13690	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Y11_RS13695	COG0756	dUTP diphosphatase activity
Y11_RS13700	COG1309	transcriptional regulator
Y11_RS13710	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Y11_RS13715	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
Y11_RS13720	COG1561	YicC-like family, N-terminal region
Y11_RS13730	COG5001	Diguanylate cyclase
Y11_RS13735	COG1024	Enoyl-CoA hydratase
Y11_RS13740	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
Y11_RS13750	COG2860	membrane
Y11_RS13755	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Y11_RS13765	COG1758	RNA polymerase activity
Y11_RS13770	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Y11_RS13775	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Y11_RS13780	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Y11_RS13790	COG0786	glutamate:sodium symporter activity
Y11_RS13795	COG2233	PERMEase
Y11_RS13800	COG2982	Protein involved in outer membrane biogenesis
Y11_RS13820	COG3423	Transcriptional regulator
Y11_RS13825	COG0456	acetyltransferase
Y11_RS13830	COG1490	D-aminoacyl-tRNA deacylase activity
Y11_RS13835	COG1295	ribonuclease BN
Y11_RS13840	COG1011	Hydrolase
Y11_RS13855	COG3852	Histidine kinase
Y11_RS13865	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Y11_RS13870	COG3078	GTPase activator activity
Y11_RS13875	COG0218	Necessary for normal cell division and for the maintenance of normal septation
Y11_RS13880	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Y11_RS13880	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Y11_RS13885	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Y11_RS13890	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
Y11_RS13895	COG3084	Protein conserved in bacteria
Y11_RS13905	COG1763	Mo-molybdopterin cofactor biosynthetic process
Y11_RS13940	COG2186	Transcriptional regulator
Y11_RS13945	COG0477	Major facilitator Superfamily
Y11_RS13950	COG1609	Transcriptional regulator
Y11_RS13955	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Y11_RS13960	COG1879	ABC-type sugar transport system periplasmic component
Y11_RS13965	COG1172	Belongs to the binding-protein-dependent transport system permease family
Y11_RS13975	COG1869	D-ribose catabolic process
Y11_RS13980	COG3158	transport of potassium into the cell
Y11_RS13985	COG0714	Associated with various cellular activities
Y11_RS13990	COG2425	protein containing a von Willebrand factor type A (vWA) domain
Y11_RS14000	COG2502	aspartate--ammonia ligase
Y11_RS14005	COG1522	sequence-specific DNA binding
Y11_RS14010	COG0716	FMN binding
Y11_RS14015	COG0445	tRNA wobble uridine modification
Y11_RS14020	COG0357	Ribosomal RNA small subunit methyltransferase G
Y11_RS14025	COG3312	ion transport
Y11_RS14030	COG0356	it plays a direct role in the translocation of protons across the membrane
Y11_RS14040	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
Y11_RS14045	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Y11_RS14050	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
Y11_RS14055	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
Y11_RS14060	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
Y11_RS14065	COG0355	proton-transporting ATP synthase activity, rotational mechanism
Y11_RS14070	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Y11_RS14080	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Y11_RS14085	COG0573	inorganic phosphate transmembrane transporter activity
Y11_RS14090	COG0581	inorganic phosphate transmembrane transporter activity
Y11_RS14100	COG0704	Plays a role in the regulation of phosphate uptake
Y11_RS14110	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Y11_RS14115	COG0765	amino acid transport
Y11_RS14120	COG0765	amino acid transport
Y11_RS14125	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Y11_RS14130	COG2252	PERMEase
Y11_RS14140	COG4566	intracellular signal transduction
Y11_RS14150	COG0431	NADPH-dependent FMN reductase
Y11_RS14155	COG0840	transmembrane signaling receptor activity
Y11_RS14160	COG2011	ABC-type metal ion transport system permease component
Y11_RS14175	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
Y11_RS14180	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Y11_RS14185	COG0706	membrane insertase activity
Y11_RS14190	COG0594	ribonuclease P activity
Y11_RS14195	COG0230	Belongs to the bacterial ribosomal protein bL34 family
Y11_RS14200	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Y11_RS14205	COG0592	DNA-directed DNA polymerase activity
Y11_RS14210	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
Y11_RS14215	COG0187	DNA topoisomerase II activity
Y11_RS14220	COG0561	phosphatase activity
Y11_RS14225	COG2423	ornithine cyclodeaminase activity
Y11_RS14235	COG0823	Involved in the tonB-independent uptake of proteins
Y11_RS14240	COG5645	(Lipo)protein
Y11_RS14270	COG0569	domain protein
Y11_RS14270	COG2985	domain, Protein
Y11_RS14275	COG3977	Valine--pyruvate aminotransferase
Y11_RS14280	COG0366	Alpha amylase catalytic
Y11_RS14285	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Y11_RS14315	COG0456	acetyltransferase
Y11_RS14320	COG2818	Glycosylase
Y11_RS14325	COG0752	glycyl-tRNA synthetase alpha subunit
Y11_RS14330	COG0751	glycine-tRNA ligase activity
Y11_RS14340	COG2213	PTS system mannitol-specific
Y11_RS14340	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
Y11_RS14345	COG0246	Mannitol dehydrogenase
Y11_RS14350	COG3722	fumarate hydratase activity
Y11_RS14360	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Y11_RS14380	COG2258	MOSC domain
Y11_RS14385	COG0840	transmembrane signaling receptor activity
Y11_RS14390	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
Y11_RS14395	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
Y11_RS14400	COG0243	molybdopterin cofactor binding
Y11_RS14400	COG3383	formate dehydrogenase (NAD+) activity
Y11_RS14405	COG3383	formate dehydrogenase (NAD+) activity
Y11_RS14405	COG0243	molybdopterin cofactor binding
Y11_RS14410	COG0437	4 iron, 4 sulfur cluster binding
Y11_RS14415	COG2864	formate dehydrogenase
Y11_RS14420	COG3058	Necessary for formate dehydrogenase activity
Y11_RS14425	COG1921	L-seryl-tRNASec selenium transferase activity
Y11_RS14430	COG3276	selenocysteine insertion sequence binding
Y11_RS14440	COG3274	enterobacterial common antigen metabolic process
Y11_RS14455	COG3121	Chaperone
Y11_RS14460	COG1070	Carbohydrate kinase
Y11_RS14470	COG4213	ABC transporter substrate-binding protein
Y11_RS14480	COG4214	carbohydrate transport
Y11_RS14490	COG0582	viral genome integration into host DNA
Y11_RS14525	COG2986	histidine ammonia-lyase
Y11_RS14530	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
Y11_RS14545	COG1482	cell wall glycoprotein biosynthetic process
Y11_RS14550	COG2723	6-phospho-beta-galactosidase activity
Y11_RS14565	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
Y11_RS14570	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
Y11_RS14575	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
Y11_RS14580	COG1447	Phosphotransferase system cellobiose-specific component IIA
Y11_RS14585	COG1940	carbohydrate kinase activity
Y11_RS14590	COG1609	Transcriptional regulator
Y11_RS14610	COG3328	transposase activity
Y11_RS14620	COG3210	domain, Protein
Y11_RS14625	COG2831	hemolysin activation secretion protein
Y11_RS14650	COG2271	Major facilitator Superfamily
Y11_RS14655	COG3851	Histidine kinase
Y11_RS14660	COG2197	response regulator
Y11_RS14665	COG2194	sulfuric ester hydrolase activity
Y11_RS14670	COG1764	response to oxidative stress
Y11_RS14680	COG0747	negative chemotaxis
Y11_RS14685	COG0601	transmembrane transport
Y11_RS14690	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Y11_RS14695	COG0444	Belongs to the ABC transporter superfamily
Y11_RS14700	COG4608	Belongs to the ABC transporter superfamily
Y11_RS14705	COG2194	sulfuric ester hydrolase activity
Y11_RS14725	COG1192	Involved in chromosome partitioning
Y11_RS14730	COG1215	transferase activity, transferring glycosyl groups
Y11_RS14735	COG1215	transferase activity, transferring glycosyl groups
Y11_RS14740	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
Y11_RS14755	COG2199	diguanylate cyclase activity
Y11_RS14755	COG2200	EAL domain
Y11_RS14760	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
Y11_RS14775	COG1301	dicarboxylic acid transport
Y11_RS14780	COG0612	Peptidase, M16
Y11_RS14785	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Y11_RS14790	COG1942	4-Oxalocrotonate Tautomerase
Y11_RS14795	COG2200	EAL domain
Y11_RS14800	COG2982	Protein involved in outer membrane biogenesis
Y11_RS14805	COG2134	cdp-diacylglycerol pyrophosphatase
Y11_RS14810	COG1295	ribonuclease BN
Y11_RS14820	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Y11_RS14825	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
Y11_RS14835	COG0742	ribosomal rna small subunit methyltransferase
Y11_RS14850	COG0589	response to stress
Y11_RS14860	COG0306	phosphate transporter
Y11_RS14865	COG2081	HI0933 family
Y11_RS14870	COG1301	dicarboxylic acid transport
Y11_RS14885	COG3799	methylaspartate ammonia-lyase activity
Y11_RS14890	COG4865	methylaspartate mutase activity
Y11_RS14900	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Y11_RS14910	COG1648	precorrin-2 dehydrogenase activity
Y11_RS14910	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Y11_RS14915	COG0583	DNA-binding transcription factor activity
Y11_RS14920	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
Y11_RS14920	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
Y11_RS14930	COG0561	phosphatase activity
Y11_RS14940	COG0583	DNA-binding transcription factor activity
Y11_RS14945	COG2814	Major facilitator Superfamily
Y11_RS14955	COG3718	enzyme involved in inositol metabolism
Y11_RS14965	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Y11_RS14975	COG0673	inositol 2-dehydrogenase activity
Y11_RS14980	COG1082	Xylose isomerase domain protein TIM barrel
Y11_RS14985	COG1247	-acetyltransferase
Y11_RS14990	COG1741	Belongs to the pirin family
Y11_RS14995	COG1609	Transcriptional regulator
Y11_RS15000	COG2610	gluconate transmembrane transporter activity
Y11_RS15005	COG3265	gluconokinase activity
Y11_RS15010	COG2095	MarC family integral membrane protein
Y11_RS15015	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
Y11_RS15035	COG3275	phosphorelay sensor kinase activity
Y11_RS15040	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
Y11_RS15045	COG1523	belongs to the glycosyl hydrolase 13 family
Y11_RS15055	COG0297	glycogen (starch) synthase activity
Y11_RS15060	COG0058	SHG alpha-glucan phosphorylase activity
Y11_RS15065	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
Y11_RS15075	COG1349	DNA-binding transcription factor activity
Y11_RS15080	COG0705	Rhomboid family
Y11_RS15095	COG2909	trisaccharide binding
Y11_RS15100	COG0058	SHG alpha-glucan phosphorylase activity
Y11_RS15105	COG1640	4-alpha-glucanotransferase
Y11_RS15115	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
Y11_RS15115	COG0316	Belongs to the HesB IscA family
Y11_RS15125	COG0596	Alpha beta hydrolase
Y11_RS15140	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
Y11_RS15145	COG1918	ferrous iron import across plasma membrane
Y11_RS15150	COG2183	response to ionizing radiation
Y11_RS15175	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Y11_RS15190	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
Y11_RS15200	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
Y11_RS15205	COG1011	Hydrolase
Y11_RS15215	COG0494	nUDIX hydrolase
Y11_RS15220	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
Y11_RS15245	COG4796	Type ii and iii secretion system protein
Y11_RS15250	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Y11_RS15270	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
Y11_RS15280	COG0180	Tryptophanyl-tRNA synthetase
Y11_RS15285	COG1648	precorrin-2 dehydrogenase activity
Y11_RS15285	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Y11_RS15300	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Y11_RS15305	COG0402	S-adenosylhomocysteine deaminase activity
Y11_RS15310	COG0738	Major facilitator superfamily
Y11_RS15320	COG1486	melibiose metabolic process
Y11_RS15325	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Y11_RS15330	COG0433	COG0433 Predicted ATPase
Y11_RS15345	COG1289	transmembrane transporter activity
Y11_RS15355	COG1765	OsmC-like protein
Y11_RS15360	COG3954	Phosphoribulokinase
Y11_RS15365	COG3089	Belongs to the UPF0270 family
Y11_RS15370	COG0429	hydrolase of the alpha beta-hydrolase fold
Y11_RS15385	COG4521	taurine ABC transporter
Y11_RS15395	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Y11_RS15400	COG2175	clavaminate synthase activity
Y11_RS15410	COG1216	Glycosyl transferase, family 2
Y11_RS15415	COG0488	(ABC) transporter
Y11_RS15420	COG2249	NAD(P)H dehydrogenase (quinone) activity
Y11_RS15430	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
Y11_RS15435	COG1047	Peptidyl-prolyl cis-trans
Y11_RS15440	COG2900	Belongs to the SlyX family
Y11_RS15445	COG0545	Peptidyl-prolyl cis-trans isomerase
Y11_RS15450	COG2964	Protein conserved in bacteria
Y11_RS15455	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
Y11_RS15460	COG2923	Belongs to the DsrF TusC family
Y11_RS15465	COG2168	tRNA wobble position uridine thiolation
Y11_RS15470	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
Y11_RS15475	COG0049	tRNA binding
Y11_RS15485	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Y11_RS15500	COG0051	transcription antitermination factor activity, RNA binding
Y11_RS15505	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
Y11_RS15510	COG0088	Forms part of the polypeptide exit tunnel
Y11_RS15515	COG0089	rRNA binding
Y11_RS15520	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Y11_RS15525	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
Y11_RS15530	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
Y11_RS15535	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
Y11_RS15540	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
Y11_RS15545	COG0255	Belongs to the universal ribosomal protein uL29 family
Y11_RS15550	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
Y11_RS15555	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
Y11_RS15560	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
Y11_RS15565	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Y11_RS15570	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
Y11_RS15580	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
Y11_RS15585	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
Y11_RS15590	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
Y11_RS15595	COG1841	ribosomal large subunit assembly
Y11_RS15600	COG0200	Binds to the 23S rRNA
Y11_RS15605	COG0201	protein transport
Y11_RS15610	COG0257	Belongs to the bacterial ribosomal protein bL36 family
Y11_RS15615	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Y11_RS15620	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Y11_RS15625	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Y11_RS15630	COG0202	RNA polymerase activity
Y11_RS15635	COG0203	ribosomal protein L17
Y11_RS15645	COG0789	Transcriptional regulator
Y11_RS15650	COG3036	rescue of stalled ribosome
Y11_RS15660	COG1970	mechanosensitive ion channel activity
Y11_RS15670	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Y11_RS15670	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Y11_RS15675	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Y11_RS15680	COG0242	peptide deformylase activity
Y11_RS15685	COG0758	DNA mediated transformation
Y11_RS15695	COG0551	DNA topoisomerase type I activity
Y11_RS15700	COG0009	L-threonylcarbamoyladenylate synthase
Y11_RS15705	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Y11_RS15710	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
Y11_RS15750	COG1879	ABC-type sugar transport system periplasmic component
Y11_RS15755	COG1129	ABC transporter
Y11_RS15760	COG1172	Belongs to the binding-protein-dependent transport system permease family
Y11_RS15765	COG1172	Belongs to the binding-protein-dependent transport system permease family
Y11_RS15770	COG0583	DNA-binding transcription factor activity
Y11_RS15775	COG3085	chromosome segregation
Y11_RS15790	COG3978	acetolactate synthase activity
Y11_RS15795	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Y11_RS15800	COG0129	dihydroxy-acid dehydratase activity
Y11_RS15820	COG0583	DNA-binding transcription factor activity
Y11_RS15825	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
Y11_RS15850	COG3121	Chaperone
Y11_RS15865	COG3121	Chaperone
Y11_RS15875	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Y11_RS15890	COG0248	Ppx GppA phosphatase
Y11_RS15900	COG3118	belongs to the thioredoxin family
Y11_RS15905	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
Y11_RS15910	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Y11_RS15915	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
Y11_RS15920	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
Y11_RS15925	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
Y11_RS15930	COG1088	dTDP-glucose 4,6-dehydratase activity
Y11_RS15935	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
Y11_RS15940	COG0456	acetyltransferase
Y11_RS15945	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
Y11_RS15950	COG2244	polysaccharide biosynthetic process
Y11_RS15955	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
Y11_RS16005	COG3071	HemY protein
Y11_RS16010	COG2959	enzyme of heme biosynthesis
Y11_RS16015	COG1587	Uroporphyrinogen-III synthase
Y11_RS16020	COG0181	hydroxymethylbilane synthase activity
Y11_RS16025	COG3072	Adenylate cyclase
Y11_RS16030	COG1965	Belongs to the frataxin family
Y11_RS16040	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
Y11_RS16045	COG3159	Protein conserved in bacteria
Y11_RS16050	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
Y11_RS16055	COG1011	Hydrolase
Y11_RS16060	COG0210	DNA helicase
Y11_RS16070	COG5441	Belongs to the UPF0261 family
Y11_RS16075	COG5564	TIM-barrel signal transduction protein
Y11_RS16090	COG2050	protein possibly involved in aromatic compounds catabolism
Y11_RS16095	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
Y11_RS16100	COG0514	ATP-dependent DNA helicase (RecQ)
Y11_RS16105	COG1280	lysine exporter protein (LysE YggA)
Y11_RS16110	COG1280	lysine exporter protein (LysE YggA)
Y11_RS16115	COG2267	carboxylic ester hydrolase activity
Y11_RS16120	COG0561	phosphatase activity
Y11_RS16130	COG0584	glycerophosphoryl diester phosphodiesterase
Y11_RS16135	COG2271	Major facilitator Superfamily
Y11_RS16140	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
Y11_RS16145	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
Y11_RS16150	COG0247	lactate metabolic process
Y11_RS16160	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
Y11_RS16165	COG0425	Belongs to the sulfur carrier protein TusA family
Y11_RS16170	COG2217	Heavy metal translocating P-type atpase
Y11_RS16175	COG3714	YhhN family
Y11_RS16190	COG3776	membrane
Y11_RS16195	COG0742	ribosomal rna small subunit methyltransferase
Y11_RS16200	COG0552	protein localization to endoplasmic reticulum
Y11_RS16205	COG2884	Cell division ATP-binding protein ftsE
Y11_RS16210	COG2177	Part of the ABC transporter FtsEX involved in
Y11_RS16235	COG0683	leucine binding
Y11_RS16245	COG4177	L-phenylalanine transmembrane transporter activity
Y11_RS16255	COG0410	ABC transporter
Y11_RS16295	COG1175	transmembrane transport
Y11_RS16300	COG0395	ABC-type sugar transport system, permease component
Y11_RS16305	COG3842	ATPase activity
Y11_RS16310	COG0584	glycerophosphoryl diester phosphodiesterase
Y11_RS16315	COG0679	Auxin Efflux Carrier
Y11_RS16320	COG0697	spore germination
Y11_RS16325	COG0583	DNA-binding transcription factor activity
Y11_RS16330	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
Y11_RS16335	COG0412	Dienelactone hydrolase
Y11_RS16355	COG1966	Carbon starvation protein
Y11_RS16360	COG0586	Pfam SNARE associated Golgi protein
Y11_RS16365	COG1322	Protein conserved in bacteria
Y11_RS16370	COG2226	methyltransferase
Y11_RS16380	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
Y11_RS16385	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Y11_RS16390	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Y11_RS16395	COG0805	protein transport
Y11_RS16415	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
Y11_RS16425	COG0183	Belongs to the thiolase family
Y11_RS16430	COG1024	Enoyl-CoA hydratase
Y11_RS16430	COG1250	3-hydroxyacyl-CoA dehydrogenase
Y11_RS16435	COG0006	proline dipeptidase activity
Y11_RS16440	COG1739	Uncharacterized protein family UPF0029
Y11_RS16445	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
Y11_RS16490	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
Y11_RS16490	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
Y11_RS16495	COG1072	(Pantothenic acid kinase))
Y11_RS16525	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Y11_RS16535	COG0250	Participates in transcription elongation, termination and antitermination
Y11_RS16540	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
Y11_RS16545	COG0081	regulation of translation
Y11_RS16550	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
Y11_RS16555	COG0222	ribosome binding
Y11_RS16560	COG0085	RNA polymerase activity
Y11_RS16565	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Y11_RS16580	COG2022	thiamine diphosphate biosynthetic process
Y11_RS16585	COG2104	thiamine diphosphate biosynthetic process
Y11_RS16590	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Y11_RS16605	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
Y11_RS16610	COG2816	NAD+ diphosphatase activity
Y11_RS16615	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
Y11_RS16620	COG1515	deoxyribonuclease V activity
Y11_RS16640	COG0151	Belongs to the GarS family
Y11_RS16645	COG0138	bifunctional purine biosynthesis protein purh
Y11_RS16685	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Y11_RS16690	COG3162	membrane
Y11_RS16695	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Y11_RS16700	COG1301	dicarboxylic acid transport
Y11_RS16705	COG2197	response regulator
Y11_RS16710	COG5002	protein histidine kinase activity
Y11_RS16710	COG2205	protein histidine kinase activity
Y11_RS16710	COG0784	Response regulator, receiver
Y11_RS16860	COG2391	methyltransferase activity
Y11_RS16870	COG0425	Belongs to the sulfur carrier protein TusA family
Y11_RS16885	COG3712	iron ion homeostasis
Y11_RS16890	COG4771	TonB-dependent receptor
Y11_RS16895	COG4178	(ABC) transporter
Y11_RS16900	COG0612	Peptidase, M16
Y11_RS16905	COG2161	toxin-antitoxin pair type II binding
Y11_RS16910	COG4115	mRNA cleavage
Y11_RS16915	COG3264	Mechanosensitive ion channel
Y11_RS16915	COG1511	domain protein
Y11_RS16920	COG4774	siderophore transport
Y11_RS16925	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Y11_RS16930	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
Y11_RS16935	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Y11_RS16940	COG4558	Periplasmic binding protein
Y11_RS16945	COG3720	iron ion transport
Y11_RS16965	COG3721	Heme iron utilization protein
Y11_RS16975	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
Y11_RS16980	COG0814	amino acid
Y11_RS16985	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
Y11_RS16990	COG1882	Formate acetyltransferase
Y11_RS17000	COG1309	transcriptional regulator
Y11_RS17005	COG1929	Belongs to the glycerate kinase type-1 family
Y11_RS17010	COG1929	Belongs to the glycerate kinase type-1 family
Y11_RS17015	COG4232	protein-disulfide reductase activity
Y11_RS17025	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
Y11_RS17040	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Y11_RS17045	COG0459	protein refolding
Y11_RS17065	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Y11_RS17085	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
Y11_RS17090	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
Y11_RS17095	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
Y11_RS17100	COG1053	succinate dehydrogenase
Y11_RS17105	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
Y11_RS17110	COG1511	domain protein
Y11_RS17110	COG3264	Mechanosensitive ion channel
Y11_RS17115	COG0688	phosphatidylethanolamine metabolic process
Y11_RS17120	COG1162	GTPase activity
Y11_RS17125	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
Y11_RS17140	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
Y11_RS17145	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Y11_RS17145	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
Y11_RS17150	COG0802	atpase or kinase
Y11_RS17155	COG0860	N-Acetylmuramoyl-L-alanine amidase
Y11_RS17160	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
Y11_RS17170	COG1923	regulation of RNA biosynthetic process
Y11_RS17175	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Y11_RS17180	COG0330	HflC and HflK could
Y11_RS17185	COG0330	HflC and HflK could
Y11_RS17190	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
Y11_RS17195	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Y11_RS17200	COG1959	2 iron, 2 sulfur cluster binding
Y11_RS17205	COG0557	exoribonuclease II activity
Y11_RS17210	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Y11_RS17215	COG1960	acyl-CoA dehydrogenase activity
Y11_RS17220	COG1960	acyl-CoA dehydrogenase activity
Y11_RS17225	COG3650	response to hydrogen peroxide
Y11_RS17230	COG1073	alpha beta
Y11_RS17240	COG0360	Binds together with S18 to 16S ribosomal RNA
Y11_RS17245	COG2965	DNA replication, synthesis of RNA primer
Y11_RS17250	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
Y11_RS17255	COG0359	binds to the 23S rRNA
Y11_RS17265	COG3061	Opacity-associated protein A
Y11_RS17270	COG0545	Peptidyl-prolyl cis-trans isomerase
Y11_RS17280	COG0737	Belongs to the 5'-nucleotidase family
Y11_RS17285	COG1218	3'(2'),5'-bisphosphate nucleotidase
Y11_RS17290	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
Y11_RS17300	COG1253	flavin adenine dinucleotide binding
Y11_RS17305	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Y11_RS17315	COG2911	Protein conserved in bacteria
Y11_RS17320	COG2105	PFAM AIG2 family protein
Y11_RS17325	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
Y11_RS17335	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
Y11_RS17340	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Y11_RS17350	COG1438	arginine binding
Y11_RS17355	COG0039	L-malate dehydrogenase activity
Y11_RS17360	COG3423	Transcriptional regulator
Y11_RS17370	COG0142	geranyltranstransferase activity
Y11_RS17375	COG0261	This protein binds to 23S rRNA in the presence of protein L20
Y11_RS17380	COG0211	Belongs to the bacterial ribosomal protein bL27 family
Y11_RS17385	COG0697	spore germination
Y11_RS17390	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Y11_RS17395	COG0642	Histidine kinase
Y11_RS17400	COG0745	RESPONSE REGULATOR receiver
Y11_RS17405	COG2027	D-alanyl-D-alanine carboxypeptidase
Y11_RS17415	COG1534	Rna-binding protein
Y11_RS17420	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
Y11_RS17430	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Y11_RS17435	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Y11_RS17440	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Y11_RS17455	COG0779	Required for maturation of 30S ribosomal subunits
Y11_RS17460	COG0195	Participates in both transcription termination and antitermination
Y11_RS17465	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Y11_RS17470	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
Y11_RS17475	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Y11_RS17480	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
Y11_RS17485	COG1185	polyribonucleotide nucleotidyltransferase activity
Y11_RS17495	COG0513	Belongs to the DEAD box helicase family
Y11_RS17505	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Y11_RS17515	COG0814	amino acid
Y11_RS17520	COG3681	Belongs to the UPF0597 family
Y11_RS17525	COG0826	peptidase U32
Y11_RS17530	COG0826	peptidase U32
Y11_RS17535	COG3154	lipid carrier protein
Y11_RS17540	COG3153	acetyltransferase
Y11_RS17545	COG2827	Endonuclease containing a URI domain
Y11_RS17550	COG0531	amino acid
Y11_RS17555	COG1982	Orn Lys Arg decarboxylase major
Y11_RS17570	COG1653	transport
Y11_RS17575	COG1175	transmembrane transport
Y11_RS17580	COG0395	ABC-type sugar transport system, permease component
Y11_RS17585	COG3842	ATPase activity
Y11_RS17595	COG3787	Belongs to the UPF0306 family
Y11_RS17610	COG0702	epimerase
Y11_RS17615	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
Y11_RS17625	COG3454	Phosphonate metabolism
Y11_RS17630	COG4778	phosphonate C-P lyase system protein PhnL
Y11_RS17635	COG4107	phosphonate C-P lyase system protein PhnK
Y11_RS17640	COG3627	carbon phosphorus lyase activity
Y11_RS17650	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
Y11_RS17655	COG3624	Phosphonate C-P lyase system protein PhnG
Y11_RS17660	COG2188	Transcriptional regulator
Y11_RS17690	COG4608	Belongs to the ABC transporter superfamily
Y11_RS17695	COG0444	Belongs to the ABC transporter superfamily
Y11_RS17700	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Y11_RS17705	COG0601	transmembrane transport
Y11_RS17715	COG2731	YhcH YjgK YiaL family protein
Y11_RS17725	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
Y11_RS17745	COG2927	DNA polymerase III (CHI subunit)
Y11_RS17750	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
Y11_RS17755	COG0795	lipopolysaccharide-transporting ATPase activity
Y11_RS17760	COG0795	lipopolysaccharide-transporting ATPase activity
Y11_RS17805	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Y11_RS17805	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
Y11_RS17810	COG0454	-acetyltransferase
Y11_RS17855	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
Y11_RS17860	COG1830	Aldolase
Y11_RS17865	COG1879	ABC-type sugar transport system periplasmic component
Y11_RS17870	COG1172	Belongs to the binding-protein-dependent transport system permease family
Y11_RS17875	COG1172	Belongs to the binding-protein-dependent transport system permease family
Y11_RS17880	COG1129	ABC transporter
Y11_RS17885	COG2390	Transcriptional regulator
Y11_RS17890	COG1070	Carbohydrate kinase
Y11_RS17895	COG0859	PFAM glycosyl transferase family 9
Y11_RS17910	COG2235	arginine
Y11_RS17915	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Y11_RS17920	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Y11_RS17930	COG2376	Dihydroxyacetone kinase
Y11_RS17935	COG1461	Dihydroxyacetone kinase
Y11_RS17940	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
Y11_RS17940	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
Y11_RS17940	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Y11_RS17950	COG2192	nodulation
Y11_RS17980	COG3284	Transcriptional regulator
Y11_RS18015	COG4772	TonB-dependent receptor
Y11_RS18040	COG0583	DNA-binding transcription factor activity
Y11_RS18045	COG0667	Aldo Keto reductase
Y11_RS18050	COG2813	Specifically methylates the guanine in position
Y11_RS18055	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
Y11_RS18060	COG0456	acetyltransferase
Y11_RS18065	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
Y11_RS18070	COG2823	Periplasmic or secreted lipoprotein
Y11_RS18075	COG4667	esterase of the alpha-beta hydrolase superfamily
Y11_RS18080	COG0084	hydrolase, TatD family'
Y11_RS18085	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
Y11_RS18095	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
Y11_RS18100	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
Y11_RS18105	COG0813	purine-nucleoside phosphorylase activity
Y11_RS18110	COG3726	membrane protein affecting hemolysin expression
Y11_RS18115	COG0560	Phosphoserine phosphatase
Y11_RS18140	COG0604	alcohol dehydrogenase
Y11_RS18155	COG0488	(ABC) transporter
Y11_RS18160	COG2885	chlorophyll binding
Y11_RS18165	COG2199	diguanylate cyclase activity
Y11_RS18175	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Y11_RS18180	COG0741	lytic transglycosylase activity
Y11_RS18185	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
Y11_RS18190	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
Y11_RS18195	COG0406	alpha-ribazole phosphatase activity
Y11_RS18200	COG3708	Transcriptional regulator
Y11_RS18200	COG2207	Transcriptional regulator
Y11_RS18205	COG3045	CreA protein
Y11_RS18210	COG0745	RESPONSE REGULATOR receiver
Y11_RS18225	COG0083	homoserine kinase activity
Y11_RS18240	COG3022	response to hydroperoxide
Y11_RS18245	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Y11_RS18250	COG0521	Mo-molybdopterin cofactor biosynthetic process
Y11_RS18265	COG1584	GPR1 FUN34 yaaH family protein
Y11_RS18270	COG0443	Heat shock 70 kDa protein
Y11_RS18275	COG0484	heat shock protein binding
Y11_RS18280	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
Y11_RS18285	COG0583	DNA-binding transcription factor activity
Y11_RS18290	COG0268	Binds directly to 16S ribosomal RNA
Y11_RS18300	COG0196	riboflavin kinase activity
Y11_RS18305	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Y11_RS18310	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
Y11_RS18315	COG1047	Peptidyl-prolyl cis-trans
Y11_RS18320	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Y11_RS18325	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
Y11_RS18335	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Y11_RS18340	COG1280	lysine exporter protein (LysE YggA)
Y11_RS18345	COG2966	Psort location CytoplasmicMembrane, score
Y11_RS18350	COG3610	response to peptide
Y11_RS18355	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
Y11_RS18360	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
Y11_RS18365	COG2967	ApaG domain
Y11_RS18370	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Y11_RS18385	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
Y11_RS18390	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
Y11_RS18395	COG0564	pseudouridine synthase activity
Y11_RS18400	COG1388	LysM domain
Y11_RS18400	COG1470	cell adhesion involved in biofilm formation
Y11_RS18405	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Y11_RS18410	COG0417	DNA replication proofreading
Y11_RS18415	COG0586	Pfam SNARE associated Golgi protein
Y11_RS18425	COG1178	ABC-type Fe3 transport system permease component
Y11_RS18430	COG4143	(ABC) transporter
Y11_RS18445	COG4533	DNA binding
Y11_RS18450	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
Y11_RS18455	COG1882	Formate acetyltransferase
Y11_RS18460	COG2814	Major facilitator Superfamily
Y11_RS18465	COG0814	amino acid
Y11_RS18485	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Y11_RS18490	COG0473	3-isopropylmalate dehydrogenase activity
Y11_RS18495	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Y11_RS18505	COG1022	Amp-dependent synthetase and ligase
Y11_RS18510	COG0028	Belongs to the TPP enzyme family
Y11_RS18535	COG2001	Belongs to the MraZ family
Y11_RS18540	COG0275	rRNA processing
Y11_RS18545	COG3116	cell division
Y11_RS18550	COG0768	penicillin binding
Y11_RS18555	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Y11_RS18560	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
Y11_RS18565	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Y11_RS18575	COG0772	Belongs to the SEDS family
Y11_RS18580	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Y11_RS18585	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Y11_RS18595	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
Y11_RS18600	COG0849	cell division
Y11_RS18605	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
Y11_RS18625	COG0653	protein targeting
Y11_RS18630	COG0494	nUDIX hydrolase
Y11_RS18635	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
Y11_RS18650	COG0516	GMP reductase activity
Y11_RS18655	COG1459	type II secretion system
Y11_RS18660	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Y11_RS18665	COG4969	Belongs to the N-Me-Phe pilin family
Y11_RS18680	COG3725	Membrane protein required for beta-lactamase induction
Y11_RS18685	COG1113	amino acid transport
Y11_RS18690	COG2186	Transcriptional regulator
Y11_RS18695	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
Y11_RS18700	COG0508	dehydrogenase complex catalyzes the overall conversion of
Y11_RS18705	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Y11_RS18715	COG4977	sequence-specific DNA binding
Y11_RS18730	COG3112	Uncharacterised protein family (UPF0231)
Y11_RS18745	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
Y11_RS18750	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
Y11_RS18760	COG2132	Multicopper oxidase
Y11_RS18770	COG0288	reversible hydration of carbon dioxide
Y11_RS18775	COG1131	(ABC) transporter
Y11_RS18780	COG0842	Transport permease protein
Y11_RS18790	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
Y11_RS18795	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
Y11_RS18800	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
Y11_RS18805	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Y11_RS18825	COG1489	DNA binding
Y11_RS18830	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
Y11_RS18835	COG1643	Atp-dependent helicase
Y11_RS18840	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Y11_RS18845	COG1120	ATPase activity
Y11_RS18850	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
Y11_RS18855	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Y11_RS18860	COG2223	nitrite transmembrane transporter activity
Y11_RS18865	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Y11_RS18875	COG0316	Belongs to the HesB IscA family
Y11_RS18880	COG2860	membrane
Y11_RS18890	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
Y11_RS18895	COG0232	Belongs to the dGTPase family. Type 2 subfamily
Y11_RS18900	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Y11_RS18910	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Y11_RS18915	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Y11_RS18920	COG3956	TIGRFAM MazG family protein
Y11_RS18925	COG0504	CTP synthase activity
Y11_RS18930	COG0148	phosphopyruvate hydratase activity
Y11_RS18935	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
Y11_RS18940	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
Y11_RS18945	COG3079	Belongs to the UPF0149 family
Y11_RS18950	COG0006	proline dipeptidase activity
Y11_RS18955	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Y11_RS18960	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Y11_RS18965	COG0404	The glycine cleavage system catalyzes the degradation of glycine
Y11_RS18970	COG0509	glycine decarboxylation via glycine cleavage system
Y11_RS18975	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Y11_RS18975	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Y11_RS18990	COG1028	Short-chain dehydrogenase reductase Sdr
Y11_RS19000	COG1272	protein, Hemolysin III
Y11_RS19015	COG0354	folic acid binding
Y11_RS19030	COG0745	RESPONSE REGULATOR receiver
Y11_RS19040	COG4452	Inner membrane protein CreD
Y11_RS19045	COG0716	FMN binding
Y11_RS19050	COG4974	Belongs to the 'phage' integrase family
Y11_RS19055	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Y11_RS19060	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
Y11_RS19065	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
Y11_RS19070	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
Y11_RS19095	COG2944	sequence-specific DNA binding
Y11_RS19100	COG3328	transposase activity
Y11_RS19115	COG4319	ketosteroid isomerase
Y11_RS19120	COG3706	GGDEF domain
Y11_RS19135	COG0484	heat shock protein binding
Y11_RS19145	COG1028	Short-chain dehydrogenase reductase Sdr
Y11_RS19150	COG1733	regulation of RNA biosynthetic process
Y11_RS19155	COG0288	reversible hydration of carbon dioxide
Y11_RS19180	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Y11_RS19190	COG2165	general secretion pathway protein
Y11_RS19265	COG2814	Major facilitator Superfamily
Y11_RS19270	COG0583	DNA-binding transcription factor activity
Y11_RS19280	COG1609	Transcriptional regulator
Y11_RS19295	COG0204	Acyl-transferase
Y11_RS19295	COG0318	PFAM AMP-dependent synthetase and ligase
Y11_RS19300	COG0477	Major facilitator Superfamily
Y11_RS19305	COG0667	Aldo Keto reductase
Y11_RS19310	COG0861	Integral membrane protein TerC family
Y11_RS19315	COG3066	DNA modification
Y11_RS19320	COG1051	belongs to the nudix hydrolase family
Y11_RS19330	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
Y11_RS19335	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
Y11_RS19340	COG2165	general secretion pathway protein
Y11_RS19355	COG4967	type IV pilus modification protein PilV
Y11_RS19360	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
Y11_RS19365	COG1025	Belongs to the peptidase M16 family
Y11_RS19370	COG1074	ATP-dependent DNA helicase activity
Y11_RS19375	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
Y11_RS19385	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
Y11_RS19385	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Y11_RS19390	COG0860	N-Acetylmuramoyl-L-alanine amidase
Y11_RS19400	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
Y11_RS19405	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
Y11_RS19410	COG2166	iron-sulfur cluster assembly
Y11_RS19415	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Y11_RS19425	COG0583	DNA-binding transcription factor activity
Y11_RS19430	COG2363	Small membrane protein
Y11_RS19435	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
Y11_RS19445	COG3328	transposase activity
Y11_RS19450	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Y11_RS19455	COG1611	Belongs to the LOG family
Y11_RS19460	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
Y11_RS19460	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
Y11_RS19470	COG3098	single-species biofilm formation
Y11_RS19475	COG0564	pseudouridine synthase activity
Y11_RS19490	COG2171	N-acyltransferase activity
Y11_RS19495	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
Y11_RS19505	COG0052	Belongs to the universal ribosomal protein uS2 family
Y11_RS19510	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Y11_RS19515	COG0528	UMP kinase activity
Y11_RS19520	COG0233	cytoplasmic translational termination
Y11_RS19525	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
Y11_RS19535	COG0575	Belongs to the CDS family
Y11_RS19540	COG0750	zinc metalloprotease
Y11_RS19550	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
Y11_RS19555	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Y11_RS19560	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Y11_RS19565	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Y11_RS19575	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
Y11_RS19585	COG0825	malonyl-CoA metabolic process
Y11_RS19590	COG1982	Orn Lys Arg decarboxylase major
Y11_RS19595	COG0346	lactoylglutathione lyase activity
Y11_RS19610	COG4568	rho-dependent transcription termination
Y11_RS19620	COG4681	YaeQ
Y11_RS19630	COG3015	lipoprotein NlpE involved in copper resistance
Y11_RS19635	COG0442	prolyl-tRNA aminoacylation
Y11_RS19640	COG1720	tRNA m6t6A37 methyltransferase activity
Y11_RS19650	COG1464	Belongs to the NlpA lipoprotein family
Y11_RS19655	COG2011	ABC-type metal ion transport system permease component
Y11_RS19665	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
Y11_RS19695	COG3328	transposase activity
Y11_RS19705	COG0656	L-ascorbic acid biosynthetic process
Y11_RS19710	COG0583	DNA-binding transcription factor activity
Y11_RS19715	COG2814	Major facilitator Superfamily
Y11_RS19720	COG3021	interspecies interaction between organisms
Y11_RS19730	COG1388	LysM domain
Y11_RS19730	COG0741	lytic transglycosylase activity
Y11_RS19735	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Y11_RS19740	COG2226	methyltransferase
Y11_RS19745	COG0328	RNA-DNA hybrid ribonuclease activity
Y11_RS19760	COG2113	Glycine betaine
Y11_RS19765	COG4176	ABC-type proline glycine betaine transport system permease component
Y11_RS19775	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Y11_RS19785	COG1780	Probably involved in ribonucleotide reductase function
Y11_RS19795	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
Y11_RS19805	COG4575	ribosome binding
Y11_RS19825	COG2207	Transcriptional regulator
Y11_RS19850	COG1278	Cold shock
Y11_RS19890	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Y11_RS19900	COG1124	(ABC) transporter
Y11_RS19910	COG0831	urea catabolic process
Y11_RS19915	COG0832	Belongs to the urease beta subunit family
Y11_RS19920	COG0804	urea catabolic process
Y11_RS19925	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
Y11_RS19930	COG0830	nickel cation binding
Y11_RS19935	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
Y11_RS19940	COG0829	nickel cation binding
Y11_RS19945	COG4413	Urea transporter
Y11_RS19950	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
Y11_RS19960	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
Y11_RS19975	COG0667	Aldo Keto reductase
Y11_RS19990	COG2133	pyrroloquinoline quinone binding
Y11_RS19995	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
Y11_RS20000	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
Y11_RS20005	COG2723	6-phospho-beta-galactosidase activity
Y11_RS20010	COG1447	Phosphotransferase system cellobiose-specific component IIA
Y11_RS20015	COG1917	Cupin 2, conserved barrel domain protein
Y11_RS20015	COG2169	Transcriptional regulator
Y11_RS20020	COG3394	polysaccharide catabolic process
Y11_RS20025	COG0659	secondary active sulfate transmembrane transporter activity
Y11_RS20035	COG3328	transposase activity
Y11_RS20040	COG0582	viral genome integration into host DNA
Y11_RS20045	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
Y11_RS20050	COG2867	negative regulation of translational initiation
Y11_RS20060	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Y11_RS20065	COG0497	DNA recombination
Y11_RS20070	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Y11_RS20075	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Y11_RS20080	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
Y11_RS20085	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
Y11_RS20120	COG0513	Belongs to the DEAD box helicase family
Y11_RS20125	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
Y11_RS20130	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
Y11_RS20140	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
Y11_RS20150	COG3086	response to oxidative stress
Y11_RS20160	COG0481	GTPase activity
Y11_RS20170	COG0571	ribonuclease III activity
Y11_RS20175	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
Y11_RS20180	COG1381	Involved in DNA repair and RecF pathway recombination
Y11_RS20185	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
Y11_RS20190	COG0736	holo-[acyl-carrier-protein] synthase activity
Y11_RS20195	COG2610	gluconate transmembrane transporter activity
Y11_RS20200	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
Y11_RS20205	COG1737	Transcriptional regulator
Y11_RS20215	COG0560	Phosphoserine phosphatase
Y11_RS20230	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
Y11_RS20245	COG2205	protein histidine kinase activity
Y11_RS20250	COG3170	Tfp pilus assembly protein FimV
Y11_RS20255	COG2204	response regulator
Y11_RS20260	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Y11_RS20260	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Y11_RS20265	COG0347	Belongs to the P(II) protein family
Y11_RS20280	COG1735	metal-dependent hydrolase with the TIM-barrel fold
Y11_RS20285	COG3457	Alanine racemase
Y11_RS20295	COG2188	Transcriptional regulator
Y11_RS20300	COG1017	nitric oxide dioxygenase activity
Y11_RS20300	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Y11_RS20305	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Y11_RS20310	COG2814	Major facilitator Superfamily
Y11_RS20315	COG3711	transcriptional antiterminator
Y11_RS20320	COG3683	transport system, periplasmic component
Y11_RS20325	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
Y11_RS20335	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
Y11_RS20340	COG1959	2 iron, 2 sulfur cluster binding
Y11_RS20350	COG0822	iron-sulfur transferase activity
Y11_RS20355	COG0316	Belongs to the HesB IscA family
Y11_RS20360	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
Y11_RS20365	COG0443	Heat shock 70 kDa protein
Y11_RS20370	COG0633	Ferredoxin
Y11_RS20375	COG2975	iron-sulfur cluster assembly
Y11_RS20400	COG2373	Large extracellular alpha-helical protein
Y11_RS20405	COG4953	penicillin-binding protein 1C
Y11_RS20420	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Y11_RS20430	COG1426	Protein conserved in bacteria
Y11_RS20435	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
Y11_RS20440	COG0124	histidyl-tRNA synthetase
Y11_RS20445	COG2976	Protein conserved in bacteria
Y11_RS20450	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Y11_RS20460	COG1160	GTP binding
Y11_RS20470	COG1645	bacterial-type flagellum-dependent swarming motility
Y11_RS20475	COG1570	exodeoxyribonuclease VII activity
Y11_RS20480	COG0517	IMP dehydrogenase activity
Y11_RS20480	COG0516	GMP reductase activity
Y11_RS20485	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Y11_RS20485	COG0519	Catalyzes the synthesis of GMP from XMP
Y11_RS20520	COG0351	phosphomethylpyrimidine kinase
Y11_RS20540	COG1349	DNA-binding transcription factor activity
Y11_RS20545	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
Y11_RS20550	COG1028	Short-chain dehydrogenase reductase Sdr
Y11_RS20565	COG3730	PTS system glucitol sorbitol-specific
Y11_RS20570	COG1597	lipid kinase activity
Y11_RS20575	COG0826	peptidase U32
Y11_RS20580	COG3422	double-strand break repair
Y11_RS20585	COG0745	RESPONSE REGULATOR receiver
Y11_RS20590	COG2205	protein histidine kinase activity
Y11_RS20595	COG0477	Major facilitator Superfamily
Y11_RS20600	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Y11_RS20610	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Y11_RS20620	COG0443	Heat shock 70 kDa protein
Y11_RS20625	COG5002	protein histidine kinase activity
Y11_RS20625	COG3447	MASE1 domain protein
Y11_RS20625	COG5001	Diguanylate cyclase
Y11_RS20635	COG0581	inorganic phosphate transmembrane transporter activity
Y11_RS20640	COG0573	inorganic phosphate transmembrane transporter activity
Y11_RS20645	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
Y11_RS20660	COG2239	Acts as a magnesium transporter
Y11_RS20665	COG3447	MASE1 domain protein
Y11_RS20665	COG5001	Diguanylate cyclase
Y11_RS20665	COG5002	protein histidine kinase activity
Y11_RS20670	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Y11_RS20675	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
Y11_RS20680	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
Y11_RS20685	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
Y11_RS20690	COG2233	PERMEase
Y11_RS20705	COG4783	chaperone-mediated protein folding
Y11_RS20800	COG1876	peptidase activity
Y11_RS20845	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Y11_RS20880	COG0243	molybdopterin cofactor binding
Y11_RS20895	COG3005	denitrification pathway
Y11_RS20940	COG0408	coproporphyrinogen oxidase activity
Y11_RS21150	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Y11_RS21180	COG2814	Major facilitator Superfamily