locus-tag	class	description
CRN74_RS00005	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CRN74_RS00015	COG0772	Belongs to the SEDS family
CRN74_RS00020	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CRN74_RS00025	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CRN74_RS00035	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CRN74_RS00040	COG0849	cell division
CRN74_RS00045	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CRN74_RS00065	COG0653	protein targeting
CRN74_RS00070	COG0494	nUDIX hydrolase
CRN74_RS00075	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
CRN74_RS00095	COG0516	GMP reductase activity
CRN74_RS00100	COG1459	type II secretion system
CRN74_RS00105	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CRN74_RS00110	COG4969	Belongs to the N-Me-Phe pilin family
CRN74_RS00120	COG3023	N-Acetylmuramoyl-L-alanine amidase
CRN74_RS00125	COG3725	Membrane protein required for beta-lactamase induction
CRN74_RS00135	COG1113	amino acid transport
CRN74_RS00140	COG2186	Transcriptional regulator
CRN74_RS00145	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CRN74_RS00150	COG0508	dehydrogenase complex catalyzes the overall conversion of
CRN74_RS00155	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CRN74_RS00175	COG3112	Uncharacterised protein family (UPF0231)
CRN74_RS00190	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CRN74_RS00200	COG2132	Multicopper oxidase
CRN74_RS00210	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CRN74_RS00215	COG0288	reversible hydration of carbon dioxide
CRN74_RS00220	COG1131	(ABC) transporter
CRN74_RS00225	COG0842	Transport permease protein
CRN74_RS00230	COG0726	polysaccharide deacetylase
CRN74_RS00235	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CRN74_RS00240	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CRN74_RS00245	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CRN74_RS00250	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CRN74_RS00255	COG0617	tRNA 3'-terminal CCA addition
CRN74_RS00280	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
CRN74_RS00285	COG1643	Atp-dependent helicase
CRN74_RS00290	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CRN74_RS00295	COG1120	ATPase activity
CRN74_RS00300	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CRN74_RS00305	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CRN74_RS00310	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CRN74_RS00320	COG0316	Belongs to the HesB IscA family
CRN74_RS00335	COG2860	membrane
CRN74_RS00345	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CRN74_RS00350	COG0232	Belongs to the dGTPase family. Type 2 subfamily
CRN74_RS00355	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CRN74_RS00365	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CRN74_RS00370	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CRN74_RS00375	COG3956	TIGRFAM MazG family protein
CRN74_RS00380	COG0504	CTP synthase activity
CRN74_RS00395	COG0602	queuosine metabolic process
CRN74_RS00400	COG0720	synthase
CRN74_RS00405	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CRN74_RS00410	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CRN74_RS00415	COG0175	sulfate reduction
CRN74_RS00420	COG2234	aminopeptidase activity
CRN74_RS00425	COG1648	precorrin-2 dehydrogenase activity
CRN74_RS00425	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CRN74_RS00430	COG0175	sulfate reduction
CRN74_RS00435	COG2895	sulfate adenylyltransferase (ATP) activity
CRN74_RS00440	COG0529	Catalyzes the synthesis of activated sulfate
CRN74_RS00455	COG0765	amino acid transport
CRN74_RS00470	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
CRN74_RS00480	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CRN74_RS00485	COG0585	pseudouridine synthase activity
CRN74_RS00490	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CRN74_RS00500	COG1388	LysM domain
CRN74_RS00500	COG4942	peptidase
CRN74_RS00505	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CRN74_RS00510	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CRN74_RS00515	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CRN74_RS00530	COG0626	cystathionine gamma-synthase activity
CRN74_RS00545	COG3121	Chaperone
CRN74_RS00555	COG3121	Chaperone
CRN74_RS00560	COG3121	Chaperone
CRN74_RS00575	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CRN74_RS00575	COG1263	PTS System
CRN74_RS00580	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CRN74_RS00590	COG1472	Belongs to the glycosyl hydrolase 3 family
CRN74_RS00600	COG3876	Protein conserved in bacteria
CRN74_RS00625	COG3188	usher protein
CRN74_RS00630	COG3121	Chaperone
CRN74_RS00645	COG3539	Fimbrial protein
CRN74_RS00650	COG3539	Fimbrial protein
CRN74_RS00680	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CRN74_RS00685	COG1136	(ABC) transporter
CRN74_RS00685	COG0577	efflux transmembrane transporter activity
CRN74_RS00690	COG1538	Outer membrane efflux protein
CRN74_RS00710	COG1028	Short-chain dehydrogenase reductase Sdr
CRN74_RS00730	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CRN74_RS00735	COG4948	Mandelate Racemase Muconate Lactonizing
CRN74_RS00740	COG0747	negative chemotaxis
CRN74_RS00745	COG0601	transmembrane transport
CRN74_RS00750	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CRN74_RS00755	COG0444	Belongs to the ABC transporter superfamily
CRN74_RS00760	COG4608	Belongs to the ABC transporter superfamily
CRN74_RS00765	COG0583	DNA-binding transcription factor activity
CRN74_RS00770	COG2610	gluconate transmembrane transporter activity
CRN74_RS00775	COG3048	D-serine ammonia-lyase activity
CRN74_RS00780	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CRN74_RS00785	COG0765	amino acid transport
CRN74_RS00790	COG0765	amino acid transport
CRN74_RS00795	COG1126	abc transporter atp-binding protein
CRN74_RS00800	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CRN74_RS00815	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CRN74_RS00820	COG0640	Transcriptional regulator
CRN74_RS00875	COG0410	ABC transporter
CRN74_RS00880	COG1137	ATPase activity
CRN74_RS00885	COG4177	L-phenylalanine transmembrane transporter activity
CRN74_RS00900	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
CRN74_RS00900	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
CRN74_RS00905	COG1070	Carbohydrate kinase
CRN74_RS00910	COG3623	hexulose-6-phosphate isomerase
CRN74_RS00920	COG1172	Belongs to the binding-protein-dependent transport system permease family
CRN74_RS00925	COG1129	ABC transporter
CRN74_RS00935	COG1349	DNA-binding transcription factor activity
CRN74_RS00945	COG1349	DNA-binding transcription factor activity
CRN74_RS00955	COG1070	Carbohydrate kinase
CRN74_RS00965	COG0738	Major facilitator superfamily
CRN74_RS00970	COG0235	Class ii aldolase
CRN74_RS00975	COG1454	alcohol dehydrogenase
CRN74_RS00980	COG0243	molybdopterin cofactor binding
CRN74_RS00985	COG0437	4 iron, 4 sulfur cluster binding
CRN74_RS00990	COG3302	dmso reductase anchor subunit
CRN74_RS00995	COG3381	protein complex oligomerization
CRN74_RS01010	COG1879	ABC-type sugar transport system periplasmic component
CRN74_RS01020	COG1129	ABC transporter
CRN74_RS01025	COG1172	Belongs to the binding-protein-dependent transport system permease family
CRN74_RS01030	COG3959	Transketolase, thiamine diphosphate binding domain
CRN74_RS01035	COG3958	Transketolase
CRN74_RS01040	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CRN74_RS01065	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CRN74_RS01070	COG2137	regulation of response to DNA damage stimulus
CRN74_RS01075	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CRN74_RS01080	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
CRN74_RS01105	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CRN74_RS01110	COG1238	metal cluster binding
CRN74_RS01115	COG2918	glutathione biosynthetic process
CRN74_RS01120	COG1854	S-ribosylhomocysteine lyase activity
CRN74_RS01125	COG4536	flavin adenine dinucleotide binding
CRN74_RS01130	COG4137	Cytochrome C assembly protein
CRN74_RS01135	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CRN74_RS01150	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CRN74_RS01160	COG0335	large ribosomal subunit rRNA binding
CRN74_RS01165	COG3137	Salt-induced outer membrane protein
CRN74_RS01170	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CRN74_RS01175	COG3279	Response regulator of the LytR AlgR family
CRN74_RS01180	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CRN74_RS01185	COG1605	Chorismate mutase
CRN74_RS01185	COG0287	Prephenate dehydrogenase
CRN74_RS01190	COG0077	Prephenate dehydratase
CRN74_RS01190	COG1605	Chorismate mutase
CRN74_RS01195	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CRN74_RS01200	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CRN74_RS01210	COG0564	pseudouridine synthase activity
CRN74_RS01220	COG0542	response to heat
CRN74_RS01255	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CRN74_RS01260	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CRN74_RS01260	COG0045	succinate-CoA ligase (ADP-forming) activity
CRN74_RS01260	COG1042	CoA-binding domain protein
CRN74_RS01265	COG3148	PFAM DTW domain containing protein
CRN74_RS01270	COG3118	belongs to the thioredoxin family
CRN74_RS01275	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CRN74_RS01280	COG2814	Major facilitator Superfamily
CRN74_RS01285	COG1566	PFAM secretion protein HlyD family protein
CRN74_RS01290	COG1846	Transcriptional regulator
CRN74_RS01300	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
CRN74_RS01305	COG2814	Major facilitator Superfamily
CRN74_RS01310	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CRN74_RS01320	COG0436	Aminotransferase
CRN74_RS01325	COG0235	Class ii aldolase
CRN74_RS01335	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
CRN74_RS01345	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
CRN74_RS01360	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
CRN74_RS01365	COG1960	acyl-CoA dehydrogenase activity
CRN74_RS01375	COG0121	glutamine amidotransferase
CRN74_RS01380	COG3034	peptidoglycan biosynthetic process
CRN74_RS01385	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CRN74_RS01390	COG1805	sodium ion transport
CRN74_RS01395	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CRN74_RS01400	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CRN74_RS01405	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CRN74_RS01410	COG2871	sodium ion transport
CRN74_RS01415	COG1477	protein flavinylation
CRN74_RS01420	COG2991	Protein conserved in bacteria
CRN74_RS01430	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CRN74_RS01435	COG2195	Cleaves the N-terminal amino acid of tripeptides
CRN74_RS01445	COG1073	alpha beta
CRN74_RS01455	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CRN74_RS01460	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CRN74_RS01470	COG3459	Glycosyltransferase 36 associated
CRN74_RS01485	COG2226	methyltransferase
CRN74_RS01500	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CRN74_RS01505	COG3123	guanosine phosphorylase activity
CRN74_RS01510	COG2974	May be involved in recombination
CRN74_RS01515	COG1940	carbohydrate kinase activity
CRN74_RS01520	COG0419	ATPase involved in DNA repair
CRN74_RS01525	COG0420	3'-5' exonuclease activity
CRN74_RS01530	COG0745	RESPONSE REGULATOR receiver
CRN74_RS01535	COG5002	protein histidine kinase activity
CRN74_RS01555	COG0366	Alpha amylase catalytic
CRN74_RS01570	COG0450	alkyl hydroperoxide reductase
CRN74_RS01575	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
CRN74_RS01585	COG0343	queuine tRNA-ribosyltransferase activity
CRN74_RS01590	COG1862	Preprotein translocase
CRN74_RS01595	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CRN74_RS01600	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CRN74_RS01610	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CRN74_RS01615	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CRN74_RS01615	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CRN74_RS01630	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CRN74_RS01635	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CRN74_RS01640	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CRN74_RS01645	COG0142	geranyltranstransferase activity
CRN74_RS01655	COG0301	tRNA thio-modification
CRN74_RS01655	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CRN74_RS01660	COG0693	protein deglycase activity
CRN74_RS01665	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CRN74_RS01675	COG1666	GTP binding
CRN74_RS01680	COG2814	Major facilitator Superfamily
CRN74_RS01685	COG0109	protoheme IX farnesyltransferase activity
CRN74_RS01690	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
CRN74_RS01695	COG1845	cytochrome c oxidase, subunit III
CRN74_RS01700	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CRN74_RS01705	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CRN74_RS01715	COG2223	nitrite transmembrane transporter activity
CRN74_RS01720	COG3056	Lipoprotein
CRN74_RS01725	COG0271	Belongs to the BolA IbaG family
CRN74_RS01735	COG0544	peptidyl-prolyl cis-trans isomerase activity
CRN74_RS01740	COG0740	serine-type endopeptidase activity
CRN74_RS01745	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CRN74_RS01750	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CRN74_RS01755	COG0776	regulation of translation
CRN74_RS01760	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CRN74_RS01765	COG1555	photosystem II stabilization
CRN74_RS01770	COG0824	Thioesterase
CRN74_RS01775	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CRN74_RS01780	COG4533	DNA binding
CRN74_RS01785	COG0561	phosphatase activity
CRN74_RS01795	COG1522	sequence-specific DNA binding
CRN74_RS01800	COG1132	(ABC) transporter
CRN74_RS01805	COG1132	(ABC) transporter
CRN74_RS01810	COG0347	Belongs to the P(II) protein family
CRN74_RS01815	COG0004	ammonium transporteR
CRN74_RS01820	COG1946	Acyl-CoA thioesterase
CRN74_RS01825	COG3126	Type III secretion system lipoprotein chaperone (YscW)
CRN74_RS01830	COG3695	enzyme binding
CRN74_RS01870	COG1121	(ABC) transporter
CRN74_RS01875	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CRN74_RS01880	COG0803	Belongs to the bacterial solute-binding protein 9 family
CRN74_RS01885	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CRN74_RS01890	COG0254	rRNA binding
CRN74_RS01895	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
CRN74_RS01900	COG3457	Alanine racemase
CRN74_RS01910	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CRN74_RS01915	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CRN74_RS01920	COG1309	transcriptional regulator
CRN74_RS01925	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
CRN74_RS01930	COG1196	nuclear chromosome segregation
CRN74_RS01930	COG3264	Mechanosensitive ion channel
CRN74_RS01945	COG2832	Protein of unknown function (DUF454)
CRN74_RS01950	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CRN74_RS01965	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CRN74_RS01970	COG0326	Molecular chaperone. Has ATPase activity
CRN74_RS01975	COG0563	adenylate kinase activity
CRN74_RS01980	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CRN74_RS02010	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CRN74_RS02025	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
CRN74_RS02030	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CRN74_RS02035	COG4651	solute:proton antiporter activity
CRN74_RS02035	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CRN74_RS02040	COG2223	nitrite transmembrane transporter activity
CRN74_RS02045	COG0737	Belongs to the 5'-nucleotidase family
CRN74_RS02050	COG0582	viral genome integration into host DNA
CRN74_RS02080	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
CRN74_RS02085	COG5532	Uncharacterized conserved protein (DUF2303)
CRN74_RS02120	COG4197	protein conserved in bacteria, prophage-related
CRN74_RS02140	COG4725	Belongs to the MT-A70-like family
CRN74_RS02150	COG3645	SOS response
CRN74_RS02150	COG3646	Phage regulatory protein
CRN74_RS02155	COG1403	HNH endonuclease
CRN74_RS02170	COG3772	lysozyme
CRN74_RS02200	COG1802	Transcriptional regulator
CRN74_RS02200	COG4626	Terminase
CRN74_RS02210	COG0740	serine-type endopeptidase activity
CRN74_RS02250	COG4386	tail sheath protein
CRN74_RS02295	COG3778	Protein conserved in bacteria
CRN74_RS02315	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CRN74_RS02320	COG3735	TraB family
CRN74_RS02325	COG2217	Heavy metal translocating P-type atpase
CRN74_RS02335	COG1585	Membrane protein implicated in regulation of membrane protease activity
CRN74_RS02340	COG0330	HflC and HflK could
CRN74_RS02345	COG3118	belongs to the thioredoxin family
CRN74_RS02350	COG0300	oxidoreductase activity
CRN74_RS02355	COG2755	lipolytic protein G-D-S-L family
CRN74_RS02360	COG4181	ATPase activity
CRN74_RS02365	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
CRN74_RS02370	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CRN74_RS02375	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CRN74_RS02380	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CRN74_RS02385	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CRN74_RS02390	COG0215	cysteine-tRNA ligase activity
CRN74_RS02415	COG3188	usher protein
CRN74_RS02420	COG3121	Chaperone
CRN74_RS02430	COG3539	Fimbrial protein
CRN74_RS02450	COG2501	S4 domain
CRN74_RS02455	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CRN74_RS02470	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CRN74_RS02560	COG4197	protein conserved in bacteria, prophage-related
CRN74_RS02625	COG1783	phage Terminase large subunit
CRN74_RS02755	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
CRN74_RS02780	COG0582	viral genome integration into host DNA
CRN74_RS02790	COG3064	Membrane
CRN74_RS02815	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
CRN74_RS02830	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CRN74_RS02835	COG2313	pseudouridylate synthase activity
CRN74_RS02840	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CRN74_RS02875	COG2979	Protein of unknown function (DUF533)
CRN74_RS02885	COG0471	metal ion transport
CRN74_RS02895	COG2188	Transcriptional regulator
CRN74_RS02900	COG2850	peptidyl-arginine hydroxylation
CRN74_RS02905	COG5265	(ABC) transporter
CRN74_RS02920	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CRN74_RS02930	COG2197	response regulator
CRN74_RS02935	COG1278	Cold shock
CRN74_RS02950	COG3706	GGDEF domain
CRN74_RS02955	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CRN74_RS02960	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CRN74_RS02965	COG0321	lipoyl(octanoyl) transferase activity
CRN74_RS02970	COG2921	Belongs to the UPF0250 family
CRN74_RS02975	COG1686	Belongs to the peptidase S11 family
CRN74_RS02980	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CRN74_RS02985	COG0772	Belongs to the SEDS family
CRN74_RS02990	COG0768	penicillin binding
CRN74_RS03000	COG0799	negative regulation of ribosome biogenesis
CRN74_RS03005	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CRN74_RS03010	COG1466	dna polymerase III delta subunit
CRN74_RS03015	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
CRN74_RS03025	COG2888	peptidyl-tyrosine sulfation
CRN74_RS03030	COG1126	abc transporter atp-binding protein
CRN74_RS03035	COG0765	amino acid transport
CRN74_RS03040	COG0765	amino acid transport
CRN74_RS03045	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CRN74_RS03055	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CRN74_RS03060	COG4535	Mg2 and Co2 transporter CorC
CRN74_RS03065	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CRN74_RS03070	COG1702	phosphate starvation-inducible protein PhoH
CRN74_RS03075	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CRN74_RS03080	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CRN74_RS03115	COG0367	asparagine synthase
CRN74_RS03120	COG0647	UMP catabolic process
CRN74_RS03125	COG1846	Transcriptional regulator
CRN74_RS03125	COG1940	carbohydrate kinase activity
CRN74_RS03130	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CRN74_RS03140	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CRN74_RS03140	COG2190	(PTS) system
CRN74_RS03140	COG1263	PTS System
CRN74_RS03145	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CRN74_RS03170	COG0735	belongs to the Fur family
CRN74_RS03180	COG0840	transmembrane signaling receptor activity
CRN74_RS03190	COG0596	Alpha beta hydrolase
CRN74_RS03195	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
CRN74_RS03200	COG0033	Phosphoglucomutase
CRN74_RS03210	COG0745	RESPONSE REGULATOR receiver
CRN74_RS03215	COG2205	protein histidine kinase activity
CRN74_RS03220	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
CRN74_RS03225	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
CRN74_RS03230	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
CRN74_RS03245	COG3272	Protein of unknown function (DUF1722)
CRN74_RS03255	COG5212	phosphodiesterase
CRN74_RS03260	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CRN74_RS03265	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CRN74_RS03270	COG1984	allophanate hydrolase subunit 2
CRN74_RS03275	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CRN74_RS03305	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
CRN74_RS03310	COG1053	succinate dehydrogenase
CRN74_RS03315	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CRN74_RS03320	COG0567	Dehydrogenase, E1 component
CRN74_RS03325	COG0508	dehydrogenase complex catalyzes the overall conversion of
CRN74_RS03335	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CRN74_RS03340	COG0737	Belongs to the 5'-nucleotidase family
CRN74_RS03345	COG1271	oxidase subunit
CRN74_RS03350	COG1294	oxidase, subunit
CRN74_RS03355	COG4890	Cyd operon protein YbgT
CRN74_RS03360	COG3790	cyd operon protein YbgE
CRN74_RS03365	COG0824	Thioesterase
CRN74_RS03370	COG0811	peptide transport
CRN74_RS03375	COG0848	biopolymer transport protein
CRN74_RS03380	COG3064	Membrane
CRN74_RS03380	COG3064	Membrane
CRN74_RS03385	COG0823	Involved in the tonB-independent uptake of proteins
CRN74_RS03390	COG2885	chlorophyll binding
CRN74_RS03395	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
CRN74_RS03425	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CRN74_RS03435	COG1230	cation diffusion facilitator family transporter
CRN74_RS03440	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CRN74_RS03445	COG0588	phosphoglycerate mutase activity
CRN74_RS03455	COG2017	converts alpha-aldose to the beta-anomer
CRN74_RS03460	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CRN74_RS03465	COG1085	galactose-1-phosphate uridylyltransferase
CRN74_RS03470	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CRN74_RS03480	COG1119	ATPase activity
CRN74_RS03485	COG3585	molybdate ion transport
CRN74_RS03485	COG2005	Transcriptional regulator
CRN74_RS03495	COG0725	ABC transporter, periplasmic molybdate-binding protein
CRN74_RS03500	COG4149	molybdate abc transporter
CRN74_RS03510	COG3037	sugar-specific permease SgaT UlaA
CRN74_RS03520	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CRN74_RS03525	COG1609	Transcriptional regulator
CRN74_RS03530	COG0280	phosphate acetyltransferase
CRN74_RS03530	COG0857	belongs to the CobB CobQ family
CRN74_RS03545	COG3092	negative regulation of chromosome organization
CRN74_RS03550	COG3013	Belongs to the UPF0304 family
CRN74_RS03555	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CRN74_RS03565	COG0490	domain, Protein
CRN74_RS03565	COG0471	metal ion transport
CRN74_RS03570	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
CRN74_RS03575	COG0436	Aminotransferase
CRN74_RS03580	COG0583	DNA-binding transcription factor activity
CRN74_RS03585	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CRN74_RS03590	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CRN74_RS03595	COG0649	NAD binding
CRN74_RS03595	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CRN74_RS03610	COG1034	ATP synthesis coupled electron transport
CRN74_RS03615	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CRN74_RS03620	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CRN74_RS03625	COG0839	Belongs to the complex I subunit 6 family
CRN74_RS03630	COG0713	ATP synthesis coupled electron transport
CRN74_RS03635	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CRN74_RS03640	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CRN74_RS03645	COG1007	ATP synthesis coupled electron transport
CRN74_RS03665	COG2731	YhcH YjgK YiaL family protein
CRN74_RS03670	COG3265	gluconokinase activity
CRN74_RS03675	COG1028	Short-chain dehydrogenase reductase Sdr
CRN74_RS03680	COG1609	Transcriptional regulator
CRN74_RS03685	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CRN74_RS03695	COG4702	Belongs to the UPF0303 family
CRN74_RS03700	COG0129	dihydroxy-acid dehydratase activity
CRN74_RS03705	COG4575	ribosome binding
CRN74_RS03715	COG1169	isochorismate synthase
CRN74_RS03720	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
CRN74_RS03730	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CRN74_RS03735	COG1441	menaquinone biosynthetic process
CRN74_RS03760	COG0814	amino acid
CRN74_RS03770	COG4574	serine-type endopeptidase inhibitor activity
CRN74_RS03775	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CRN74_RS03785	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CRN74_RS03800	COG2205	protein histidine kinase activity
CRN74_RS03800	COG0784	Response regulator, receiver
CRN74_RS03810	COG2198	Histidine kinase
CRN74_RS03810	COG0642	Histidine kinase
CRN74_RS03815	COG2223	nitrite transmembrane transporter activity
CRN74_RS03830	COG1132	(ABC) transporter
CRN74_RS03855	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CRN74_RS03890	COG3121	Chaperone
CRN74_RS03910	COG1737	Transcriptional regulator
CRN74_RS03915	COG2190	(PTS) system
CRN74_RS03915	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CRN74_RS03915	COG1263	PTS System
CRN74_RS03920	COG2723	6-phospho-beta-galactosidase activity
CRN74_RS03925	COG3539	Fimbrial protein
CRN74_RS03930	COG3121	Chaperone
CRN74_RS03935	COG3188	usher protein
CRN74_RS03940	COG3539	Fimbrial protein
CRN74_RS03945	COG3539	Fimbrial protein
CRN74_RS03950	COG3539	Fimbrial protein
CRN74_RS03955	COG0657	acetylesterase activity
CRN74_RS03955	COG2755	lipolytic protein G-D-S-L family
CRN74_RS03975	COG3082	Protein of unknown function (DUF1414)
CRN74_RS03980	COG3081	Nucleoid-associated protein
CRN74_RS03990	COG1061	Type III restriction enzyme res subunit
CRN74_RS03995	COG1187	pseudouridine synthase activity
CRN74_RS04000	COG2814	Major facilitator Superfamily
CRN74_RS04010	COG4172	Belongs to the ABC transporter superfamily
CRN74_RS04015	COG4239	(ABC) transporter, permease
CRN74_RS04020	COG4174	ABC transporter (Permease)
CRN74_RS04025	COG4166	transmembrane transport
CRN74_RS04030	COG2200	EAL domain
CRN74_RS04035	COG0791	NLP P60 protein
CRN74_RS04040	COG0671	phosphoesterase, PA-phosphatase related
CRN74_RS04045	COG0523	cobalamin synthesis protein
CRN74_RS04055	COG2186	Transcriptional regulator
CRN74_RS04060	COG0246	Mannitol dehydrogenase
CRN74_RS04075	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CRN74_RS04100	COG1105	Belongs to the carbohydrate kinase PfkB family
CRN74_RS04105	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CRN74_RS04105	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CRN74_RS04105	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
CRN74_RS04110	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
CRN74_RS04115	COG2855	membrane
CRN74_RS04125	COG0583	DNA-binding transcription factor activity
CRN74_RS04130	COG0833	amino acid
CRN74_RS04135	COG4771	TonB-dependent receptor
CRN74_RS04140	COG0625	glutathione transferase activity
CRN74_RS04165	COG2011	ABC-type metal ion transport system permease component
CRN74_RS04180	COG0626	cystathionine gamma-synthase activity
CRN74_RS04190	COG1686	Belongs to the peptidase S11 family
CRN74_RS04195	COG1760	l-serine dehydratase
CRN74_RS04200	COG0814	amino acid
CRN74_RS04205	COG1349	DNA-binding transcription factor activity
CRN74_RS04210	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CRN74_RS04215	COG0671	phosphoesterase, PA-phosphatase related
CRN74_RS04225	COG2985	domain, Protein
CRN74_RS04225	COG0569	domain protein
CRN74_RS04245	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CRN74_RS04250	COG3842	ATPase activity
CRN74_RS04255	COG1176	ABC-type spermidine putrescine transport system, permease component I
CRN74_RS04260	COG1177	transmembrane transport
CRN74_RS04275	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CRN74_RS04280	COG4160	amino acid transport
CRN74_RS04285	COG4215	(ABC) transporter
CRN74_RS04290	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CRN74_RS04295	COG1126	abc transporter atp-binding protein
CRN74_RS04300	COG1605	Chorismate mutase
CRN74_RS04310	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CRN74_RS04315	COG0702	epimerase
CRN74_RS04320	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
CRN74_RS04330	COG0028	Belongs to the TPP enzyme family
CRN74_RS04335	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CRN74_RS04340	COG1151	hydroxylamine reductase activity
CRN74_RS04345	COG2431	L-lysine efflux transmembrane transporter activity
CRN74_RS04350	COG3593	DNA synthesis involved in DNA repair
CRN74_RS04355	COG2990	Protein conserved in bacteria
CRN74_RS04360	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CRN74_RS04370	COG1278	Cold shock
CRN74_RS04375	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CRN74_RS04380	COG0542	response to heat
CRN74_RS04385	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CRN74_RS04390	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
CRN74_RS04395	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
CRN74_RS04405	COG0492	ferredoxin-NADP+ reductase activity
CRN74_RS04415	COG1674	ftsk spoiiie
CRN74_RS04415	COG3107	peptidoglycan biosynthetic process
CRN74_RS04420	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
CRN74_RS04425	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CRN74_RS04430	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CRN74_RS04435	COG2814	Major facilitator Superfamily
CRN74_RS04440	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CRN74_RS04445	COG1882	Formate acetyltransferase
CRN74_RS04450	COG2116	formate transmembrane transporter activity
CRN74_RS04455	COG1944	ATP diphosphatase activity
CRN74_RS04460	COG0252	asparaginase activity
CRN74_RS04465	COG2323	membrane
CRN74_RS04475	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CRN74_RS04485	COG0539	negative regulation of cytoplasmic translation
CRN74_RS04490	COG0776	regulation of translation
CRN74_RS04495	COG0658	competence protein
CRN74_RS04495	COG2333	competence protein COMEC
CRN74_RS04510	COG5383	Protein conserved in bacteria
CRN74_RS04515	COG1278	Cold shock
CRN74_RS04520	COG2835	tetraacyldisaccharide 4'-kinase activity
CRN74_RS04530	COG3173	Aminoglycoside phosphotransferase
CRN74_RS04535	COG1434	Gram-negative-bacterium-type cell wall biogenesis
CRN74_RS04540	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CRN74_RS04545	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
CRN74_RS04560	COG2989	Protein conserved in bacteria
CRN74_RS04565	COG3108	Peptidase M15
CRN74_RS04570	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CRN74_RS04575	COG2200	EAL domain
CRN74_RS04580	COG1448	Aminotransferase
CRN74_RS04590	COG0017	Asparaginyl-tRNA synthetase
CRN74_RS04595	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CRN74_RS04600	COG0308	aminopeptidase N
CRN74_RS04605	COG0167	dihydroorotate dehydrogenase activity
CRN74_RS04615	COG0633	Ferredoxin
CRN74_RS04615	COG3217	Mosc domain protein beta barrel domain protein
CRN74_RS04620	COG0116	Belongs to the methyltransferase superfamily
CRN74_RS04620	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CRN74_RS04625	COG0488	(ABC) transporter
CRN74_RS04630	COG2995	paraquat-inducible protein a
CRN74_RS04635	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CRN74_RS04635	COG3008	intermembrane lipid transfer
CRN74_RS04640	COG3009	Protein conserved in bacteria
CRN74_RS04645	COG3130	regulation of translation
CRN74_RS04650	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CRN74_RS04660	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CRN74_RS04665	COG1067	ATP-dependent peptidase activity
CRN74_RS04670	COG3120	sequence-specific DNA binding
CRN74_RS04680	COG5404	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
CRN74_RS04685	COG3070	regulator of competence-specific genes
CRN74_RS04690	COG1289	transmembrane transporter activity
CRN74_RS04695	COG3304	Inner membrane component domain
CRN74_RS04700	COG0210	DNA helicase
CRN74_RS04705	COG1803	Methylglyoxal synthase
CRN74_RS04715	COG1832	CoA-binding protein
CRN74_RS04720	COG3785	DNA binding
CRN74_RS04725	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CRN74_RS04735	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CRN74_RS04745	COG1254	Belongs to the acylphosphatase family
CRN74_RS04750	COG2920	part of a sulfur-relay system
CRN74_RS04775	COG0738	Major facilitator superfamily
CRN74_RS04785	COG1349	DNA-binding transcription factor activity
CRN74_RS04790	COG1940	carbohydrate kinase activity
CRN74_RS04795	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CRN74_RS04800	COG1172	Belongs to the binding-protein-dependent transport system permease family
CRN74_RS04805	COG1129	ABC transporter
CRN74_RS04810	COG1879	ABC-type sugar transport system periplasmic component
CRN74_RS04815	COG1737	Transcriptional regulator
CRN74_RS04820	COG0698	ribose 5-phosphate isomerase
CRN74_RS04830	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CRN74_RS04830	COG1263	PTS System
CRN74_RS04835	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CRN74_RS04840	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CRN74_RS04870	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
CRN74_RS04875	COG0437	4 iron, 4 sulfur cluster binding
CRN74_RS04880	COG3301	Polysulphide reductase, NrfD
CRN74_RS04885	COG1138	Cytochrome C-type biogenesis protein
CRN74_RS04890	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CRN74_RS04895	COG3088	subunit of a heme lyase
CRN74_RS04900	COG4235	cytochrome complex assembly
CRN74_RS04900	COG3088	subunit of a heme lyase
CRN74_RS04905	COG2771	luxR family
CRN74_RS04910	COG3916	Acyl-homoserine-lactone synthase
CRN74_RS04920	COG3263	regulation of cellular component size
CRN74_RS04935	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
CRN74_RS04940	COG2943	transferase activity, transferring hexosyl groups
CRN74_RS04945	COG5645	(Lipo)protein
CRN74_RS04960	COG2814	Major facilitator Superfamily
CRN74_RS04965	COG2259	Doxx family
CRN74_RS04970	COG1560	Kdo2-lipid A biosynthetic process
CRN74_RS05005	COG0697	spore germination
CRN74_RS05015	COG0628	permease
CRN74_RS05025	COG2197	response regulator
CRN74_RS05045	COG0418	dihydroorotase activity
CRN74_RS05050	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
CRN74_RS05055	COG1530	ribonuclease E activity
CRN74_RS05060	COG0564	pseudouridine synthase activity
CRN74_RS05070	COG1399	metal-binding, possibly nucleic acid-binding protein
CRN74_RS05075	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CRN74_RS05080	COG0416	fatty acid biosynthetic process
CRN74_RS05105	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CRN74_RS05110	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CRN74_RS05115	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CRN74_RS05120	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CRN74_RS05125	COG0470	DNA polymerase III
CRN74_RS05130	COG0084	hydrolase, TatD family'
CRN74_RS05135	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CRN74_RS05135	COG1263	PTS System
CRN74_RS05140	COG4533	DNA binding
CRN74_RS05145	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CRN74_RS05150	COG0537	adenosine 5'-monophosphoramidase activity
CRN74_RS05155	COG5633	Lipoprotein
CRN74_RS05160	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
CRN74_RS05175	COG3150	esterase
CRN74_RS05180	COG1252	NADH dehydrogenase
CRN74_RS05190	COG3134	Outer membrane lipoprotein
CRN74_RS05195	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CRN74_RS05200	COG4591	ABC-type transport system involved in lipoprotein release permease component
CRN74_RS05210	COG4591	ABC-type transport system involved in lipoprotein release permease component
CRN74_RS05215	COG1940	carbohydrate kinase activity
CRN74_RS05230	COG2850	peptidyl-arginine hydroxylation
CRN74_RS05235	COG2205	protein histidine kinase activity
CRN74_RS05240	COG0745	RESPONSE REGULATOR receiver
CRN74_RS05250	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CRN74_RS05255	COG2915	High frequency lysogenization protein hflD homolog
CRN74_RS05260	COG0482	sulfurtransferase activity
CRN74_RS05270	COG1187	pseudouridine synthase activity
CRN74_RS05275	COG0538	isocitrate dehydrogenase activity
CRN74_RS05280	COG0582	viral genome integration into host DNA
CRN74_RS05305	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
CRN74_RS05325	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CRN74_RS05330	COG4197	protein conserved in bacteria, prophage-related
CRN74_RS05345	COG4626	Terminase
CRN74_RS05345	COG1802	Transcriptional regulator
CRN74_RS05355	COG3646	Phage regulatory protein
CRN74_RS05355	COG3645	SOS response
CRN74_RS05360	COG1403	HNH endonuclease
CRN74_RS05405	COG1802	Transcriptional regulator
CRN74_RS05405	COG4626	Terminase
CRN74_RS05415	COG4695	Portal protein
CRN74_RS05455	COG4386	tail sheath protein
CRN74_RS05500	COG3299	homolog of phage Mu protein gp47
CRN74_RS05505	COG3778	Protein conserved in bacteria
CRN74_RS05540	COG0538	isocitrate dehydrogenase activity
CRN74_RS05560	COG0561	phosphatase activity
CRN74_RS05565	COG2223	nitrite transmembrane transporter activity
CRN74_RS05575	COG3189	MarR family transcriptional regulator
CRN74_RS05585	COG3493	citrate carrier protein
CRN74_RS05590	COG4565	transcriptional regulatory protein
CRN74_RS05595	COG3290	protein histidine kinase activity
CRN74_RS05600	COG2066	Belongs to the glutaminase family
CRN74_RS05615	COG1609	Transcriptional regulator
CRN74_RS05620	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CRN74_RS05625	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CRN74_RS05625	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CRN74_RS05630	COG2723	6-phospho-beta-galactosidase activity
CRN74_RS05635	COG1447	Phosphotransferase system cellobiose-specific component IIA
CRN74_RS05645	COG0672	)-iron permease
CRN74_RS05660	COG1136	(ABC) transporter
CRN74_RS05660	COG0577	efflux transmembrane transporter activity
CRN74_RS05670	COG1136	(ABC) transporter
CRN74_RS05670	COG0577	efflux transmembrane transporter activity
CRN74_RS05685	COG0500	methyltransferase
CRN74_RS05685	COG3615	Tellurite resistance protein tehB
CRN74_RS05700	COG0006	proline dipeptidase activity
CRN74_RS05705	COG0457	Tetratricopeptide repeat
CRN74_RS05710	COG1649	PFAM Uncharacterised BCR, COG1649
CRN74_RS05710	COG0726	polysaccharide deacetylase
CRN74_RS05715	COG1215	transferase activity, transferring glycosyl groups
CRN74_RS05720	COG3658	cytochrome
CRN74_RS05735	COG1702	phosphate starvation-inducible protein PhoH
CRN74_RS05740	COG0387	Pfam Sodium calcium exchanger
CRN74_RS05755	COG3850	Histidine kinase
CRN74_RS05765	COG1294	oxidase, subunit
CRN74_RS05770	COG1271	oxidase subunit
CRN74_RS05775	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CRN74_RS05780	COG3866	Pectate lyase
CRN74_RS05785	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CRN74_RS05790	COG3138	arginine N-succinyltransferase
CRN74_RS05800	COG3724	N-succinylarginine dihydrolase activity
CRN74_RS05805	COG2988	succinylglutamate desuccinylase activity
CRN74_RS05820	COG1228	amidohydrolase
CRN74_RS05830	COG0402	S-adenosylhomocysteine deaminase activity
CRN74_RS05845	COG1129	ABC transporter
CRN74_RS05850	COG4211	Belongs to the binding-protein-dependent transport system permease family
CRN74_RS05855	COG3443	Belongs to the bacterial solute-binding protein 9 family
CRN74_RS05865	COG4942	peptidase
CRN74_RS05875	COG0738	Major facilitator superfamily
CRN74_RS05880	COG0583	DNA-binding transcription factor activity
CRN74_RS05885	COG2271	Major facilitator Superfamily
CRN74_RS05900	COG4670	ketone body catabolic process
CRN74_RS05905	COG1960	acyl-CoA dehydrogenase activity
CRN74_RS05910	COG2207	Transcriptional regulator
CRN74_RS05910	COG1917	Cupin 2, conserved barrel domain protein
CRN74_RS05915	COG2086	electron transfer activity
CRN74_RS05920	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CRN74_RS05925	COG0644	oxidoreductase
CRN74_RS05930	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
CRN74_RS05935	COG0318	PFAM AMP-dependent synthetase and ligase
CRN74_RS05940	COG0667	Aldo Keto reductase
CRN74_RS05965	COG1073	alpha beta
CRN74_RS05970	COG0288	reversible hydration of carbon dioxide
CRN74_RS05975	COG0786	glutamate:sodium symporter activity
CRN74_RS05990	COG3210	domain, Protein
CRN74_RS06005	COG3210	domain, Protein
CRN74_RS06010	COG2831	hemolysin activation secretion protein
CRN74_RS06015	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
CRN74_RS06030	COG0012	GTP binding
CRN74_RS06040	COG0193	aminoacyl-tRNA hydrolase activity
CRN74_RS06050	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CRN74_RS06060	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
CRN74_RS06065	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CRN74_RS06070	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CRN74_RS06075	COG2890	protein-(glutamine-N5) methyltransferase activity
CRN74_RS06095	COG0659	secondary active sulfate transmembrane transporter activity
CRN74_RS06100	COG3706	GGDEF domain
CRN74_RS06115	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CRN74_RS06125	COG3381	protein complex oligomerization
CRN74_RS06135	COG0477	Major facilitator Superfamily
CRN74_RS06140	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CRN74_RS06150	COG0673	inositol 2-dehydrogenase activity
CRN74_RS06155	COG0728	peptidoglycan biosynthetic process
CRN74_RS06165	COG3102	Protein conserved in bacteria
CRN74_RS06170	COG3142	Participates in the control of copper homeostasis
CRN74_RS06175	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CRN74_RS06185	COG3788	relative of glutathione S-transferase, MAPEG superfamily
CRN74_RS06190	COG1801	Protein of unknown function DUF72
CRN74_RS06195	COG1335	isochorismatase
CRN74_RS06200	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CRN74_RS06205	COG0494	nUDIX hydrolase
CRN74_RS06210	COG0217	transcriptional regulatory protein
CRN74_RS06220	COG0632	four-way junction helicase activity
CRN74_RS06225	COG2255	four-way junction helicase activity
CRN74_RS06230	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CRN74_RS06235	COG1121	(ABC) transporter
CRN74_RS06240	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
CRN74_RS06245	COG0739	heme binding
CRN74_RS06250	COG1560	Kdo2-lipid A biosynthetic process
CRN74_RS06255	COG0469	pyruvate kinase activity
CRN74_RS06260	COG1737	Transcriptional regulator
CRN74_RS06265	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CRN74_RS06270	COG0800	Aldolase
CRN74_RS06275	COG3397	chitin binding
CRN74_RS06280	COG2076	Multidrug Resistance protein
CRN74_RS06285	COG2076	Multidrug Resistance protein
CRN74_RS06290	COG0251	oxidation-reduction process
CRN74_RS06295	COG1199	ATP-dependent helicase activity
CRN74_RS06305	COG3065	identical protein binding
CRN74_RS06310	COG0318	PFAM AMP-dependent synthetase and ligase
CRN74_RS06315	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
CRN74_RS06320	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
CRN74_RS06325	COG2894	cell division
CRN74_RS06330	COG0850	regulation of cytokinetic process
CRN74_RS06335	COG3100	YcgL domain-containing protein
CRN74_RS06340	COG0179	Fumarylacetoacetate (FAA) hydrolase
CRN74_RS06345	COG2983	Belongs to the UPF0260 family
CRN74_RS06355	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
CRN74_RS06360	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CRN74_RS06370	COG2186	Transcriptional regulator
CRN74_RS06375	COG0791	NLP P60 protein
CRN74_RS06385	COG4139	cobalamin transport
CRN74_RS06390	COG0386	Belongs to the glutathione peroxidase family
CRN74_RS06395	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
CRN74_RS06400	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CRN74_RS06405	COG0463	Glycosyl transferase, family 2
CRN74_RS06415	COG0726	polysaccharide deacetylase
CRN74_RS06420	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CRN74_RS06430	COG2076	Multidrug Resistance protein
CRN74_RS06435	COG0791	NLP P60 protein
CRN74_RS06440	COG0095	Lipoate-protein ligase
CRN74_RS06455	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CRN74_RS06460	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CRN74_RS06460	COG0574	Belongs to the PEP-utilizing enzyme family
CRN74_RS06470	COG0628	permease
CRN74_RS06475	COG0277	FAD linked oxidase domain protein
CRN74_RS06475	COG0247	lactate metabolic process
CRN74_RS06480	COG2050	protein possibly involved in aromatic compounds catabolism
CRN74_RS06490	COG0316	Belongs to the HesB IscA family
CRN74_RS06495	COG0719	Fe-S assembly protein
CRN74_RS06500	COG0396	ATPase activity
CRN74_RS06505	COG0719	Fe-S assembly protein
CRN74_RS06515	COG2166	iron-sulfur cluster assembly
CRN74_RS06520	COG1376	ErfK ybiS ycfS ynhG family protein
CRN74_RS06520	COG1388	LysM domain
CRN74_RS06545	COG0534	Mate efflux family protein
CRN74_RS06550	COG0307	riboflavin synthase, alpha
CRN74_RS06555	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CRN74_RS06560	COG2814	Major facilitator Superfamily
CRN74_RS06565	COG0583	DNA-binding transcription factor activity
CRN74_RS06570	COG1609	Transcriptional regulator
CRN74_RS06585	COG0791	NLP P60 protein
CRN74_RS06590	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CRN74_RS06595	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CRN74_RS06600	COG0346	lactoylglutathione lyase activity
CRN74_RS06605	COG1902	pentaerythritol trinitrate reductase activity
CRN74_RS06610	COG1309	transcriptional regulator
CRN74_RS06615	COG2194	sulfuric ester hydrolase activity
CRN74_RS06620	COG3313	Fe-S protein
CRN74_RS06625	COG4989	oxidoreductase activity
CRN74_RS06635	COG1566	PFAM secretion protein HlyD family protein
CRN74_RS06645	COG1846	Transcriptional regulator
CRN74_RS06650	COG3133	Outer membrane lipoprotein
CRN74_RS06655	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
CRN74_RS06660	COG3895	Periplasmic Protein
CRN74_RS06670	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CRN74_RS06680	COG0625	glutathione transferase activity
CRN74_RS06700	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CRN74_RS06705	COG3104	oligopeptide transport
CRN74_RS06710	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CRN74_RS06710	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CRN74_RS06720	COG4172	Belongs to the ABC transporter superfamily
CRN74_RS06730	COG4171	peptide transport system, permease
CRN74_RS06740	COG4166	transmembrane transport
CRN74_RS06745	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
CRN74_RS06750	COG1842	Phage shock protein A
CRN74_RS06760	COG1983	PspC domain protein
CRN74_RS06770	COG3106	COG3106 Predicted ATPase
CRN74_RS06775	COG3768	UPF0283 membrane protein
CRN74_RS06780	COG5654	RES domain protein
CRN74_RS06785	COG5642	Protein of unknown function (DUF2384)
CRN74_RS06795	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CRN74_RS06800	COG4948	Mandelate Racemase Muconate Lactonizing
CRN74_RS06805	COG2866	Carboxypeptidase
CRN74_RS06810	COG4166	transmembrane transport
CRN74_RS06820	COG0037	tRNA processing
CRN74_RS06825	COG3711	transcriptional antiterminator
CRN74_RS06830	COG1263	PTS System
CRN74_RS06830	COG2190	(PTS) system
CRN74_RS06830	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CRN74_RS06835	COG2723	6-phospho-beta-galactosidase activity
CRN74_RS06840	COG0674	pyruvate-flavodoxin oxidoreductase activity
CRN74_RS06840	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CRN74_RS06840	COG1013	pyruvate-flavodoxin oxidoreductase activity
CRN74_RS06840	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CRN74_RS06850	COG3042	response to heat
CRN74_RS06860	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CRN74_RS06865	COG2911	Protein conserved in bacteria
CRN74_RS06875	COG3784	Protein of unknown function (DUF1318)
CRN74_RS06885	COG1070	Carbohydrate kinase
CRN74_RS06890	COG0246	Mannitol dehydrogenase
CRN74_RS06900	COG3423	Transcriptional regulator
CRN74_RS06910	COG0477	Major facilitator Superfamily
CRN74_RS06915	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CRN74_RS06920	COG1643	Atp-dependent helicase
CRN74_RS06925	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
CRN74_RS06935	COG3591	Belongs to the peptidase S1B family
CRN74_RS06945	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
CRN74_RS06950	COG2205	protein histidine kinase activity
CRN74_RS06955	COG0745	RESPONSE REGULATOR receiver
CRN74_RS06965	COG0531	amino acid
CRN74_RS06980	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
CRN74_RS06985	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
CRN74_RS06990	COG0589	response to stress
CRN74_RS06995	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CRN74_RS07000	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CRN74_RS07015	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
CRN74_RS07025	COG1028	Short-chain dehydrogenase reductase Sdr
CRN74_RS07050	COG1011	Hydrolase
CRN74_RS07060	COG0531	amino acid
CRN74_RS07065	COG0076	glutamate decarboxylase activity
CRN74_RS07090	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CRN74_RS07115	COG1522	sequence-specific DNA binding
CRN74_RS07125	COG0625	glutathione transferase activity
CRN74_RS07165	COG0477	Major facilitator Superfamily
CRN74_RS07170	COG4221	oxidoreductase activity
CRN74_RS07175	COG1742	UPF0060 membrane protein
CRN74_RS07195	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CRN74_RS07200	COG1940	carbohydrate kinase activity
CRN74_RS07205	COG0583	DNA-binding transcription factor activity
CRN74_RS07210	COG2814	Major facilitator Superfamily
CRN74_RS07225	COG0114	fumarate hydratase activity
CRN74_RS07235	COG5339	Protein conserved in bacteria
CRN74_RS07255	COG1609	Transcriptional regulator
CRN74_RS07260	COG1263	PTS System
CRN74_RS07260	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CRN74_RS07265	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CRN74_RS07270	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CRN74_RS07275	COG0385	Bile acid
CRN74_RS07280	COG0673	inositol 2-dehydrogenase activity
CRN74_RS07290	COG1172	Belongs to the binding-protein-dependent transport system permease family
CRN74_RS07295	COG1129	ABC transporter
CRN74_RS07300	COG1879	ABC-type sugar transport system periplasmic component
CRN74_RS07310	COG2160	L-arabinose isomerase activity
CRN74_RS07315	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CRN74_RS07335	COG2759	Belongs to the formate--tetrahydrofolate ligase family
CRN74_RS07345	COG4657	Part of a membrane complex involved in electron transport
CRN74_RS07355	COG4656	Part of a membrane complex involved in electron transport
CRN74_RS07360	COG3708	Transcriptional regulator
CRN74_RS07360	COG2207	Transcriptional regulator
CRN74_RS07370	COG4659	FMN binding
CRN74_RS07380	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CRN74_RS07385	COG0243	molybdopterin cofactor binding
CRN74_RS07390	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
CRN74_RS07395	COG1966	Carbon starvation protein
CRN74_RS07400	COG2879	small protein
CRN74_RS07405	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CRN74_RS07420	COG1349	DNA-binding transcription factor activity
CRN74_RS07430	COG0235	Class ii aldolase
CRN74_RS07440	COG0023	Translation Initiation Factor
CRN74_RS07445	COG0284	orotidine-5'-phosphate decarboxylase activity
CRN74_RS07460	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
CRN74_RS07465	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
CRN74_RS07470	COG0671	phosphoesterase, PA-phosphatase related
CRN74_RS07480	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CRN74_RS07490	COG4974	Belongs to the 'phage' integrase family
CRN74_RS07540	COG0582	viral genome integration into host DNA
CRN74_RS07550	COG0583	DNA-binding transcription factor activity
CRN74_RS07570	COG0616	signal peptide processing
CRN74_RS07575	COG1028	Short-chain dehydrogenase reductase Sdr
CRN74_RS07585	COG1187	pseudouridine synthase activity
CRN74_RS07595	COG2197	response regulator
CRN74_RS07605	COG0009	L-threonylcarbamoyladenylate synthase
CRN74_RS07610	COG0613	PHP domain protein
CRN74_RS07620	COG0512	Glutamine amidotransferase of anthranilate synthase
CRN74_RS07630	COG0134	indole-3-glycerol-phosphate synthase activity
CRN74_RS07630	COG0135	phosphoribosylanthranilate isomerase activity
CRN74_RS07635	COG0133	tryptophan synthase activity
CRN74_RS07640	COG0159	tryptophan synthase activity
CRN74_RS07650	COG3047	cAMP biosynthetic process
CRN74_RS07665	COG2917	probably involved in intracellular septation
CRN74_RS07675	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
CRN74_RS07685	COG2350	Protein conserved in bacteria
CRN74_RS07695	COG2200	EAL domain
CRN74_RS07705	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CRN74_RS07710	COG3099	Belongs to the UPF0263 family
CRN74_RS07715	COG4608	Belongs to the ABC transporter superfamily
CRN74_RS07720	COG0444	Belongs to the ABC transporter superfamily
CRN74_RS07725	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CRN74_RS07740	COG4166	transmembrane transport
CRN74_RS07745	COG2095	MarC family integral membrane protein
CRN74_RS07750	COG1012	belongs to the aldehyde dehydrogenase family
CRN74_RS07750	COG1454	alcohol dehydrogenase
CRN74_RS07760	COG2916	Histone family protein nucleoid-structuring protein H-NS
CRN74_RS07770	COG0745	RESPONSE REGULATOR receiver
CRN74_RS07775	COG1752	Esterase of the alpha-beta hydrolase superfamily
CRN74_RS07785	COG3012	SEC-C Motif Domain Protein
CRN74_RS07790	COG0788	formyltetrahydrofolate deformylase activity
CRN74_RS07805	COG0583	DNA-binding transcription factor activity
CRN74_RS07810	COG0708	Exodeoxyribonuclease III
CRN74_RS07815	COG0494	nUDIX hydrolase
CRN74_RS07825	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CRN74_RS07835	COG0778	Nitroreductase
CRN74_RS07840	COG0616	signal peptide processing
CRN74_RS07845	COG0252	asparaginase activity
CRN74_RS07850	COG1335	isochorismatase
CRN74_RS07855	COG3139	Protein of unknown function (DUF1315)
CRN74_RS07885	COG3713	MltA-interacting MipA family protein
CRN74_RS07895	COG2766	serine protein kinase
CRN74_RS07900	COG2718	Belongs to the UPF0229 family
CRN74_RS07910	COG0583	DNA-binding transcription factor activity
CRN74_RS07920	COG2202	Pas domain
CRN74_RS07920	COG2199	diguanylate cyclase activity
CRN74_RS07920	COG2200	EAL domain
CRN74_RS07925	COG2814	Major facilitator Superfamily
CRN74_RS07930	COG3111	PFAM Bacterial OB fold (BOF) protein
CRN74_RS07940	COG0642	Histidine kinase
CRN74_RS07945	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CRN74_RS07950	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CRN74_RS07955	COG2719	SpoVR family
CRN74_RS07965	COG4974	Belongs to the 'phage' integrase family
CRN74_RS08045	COG4695	Portal protein
CRN74_RS08180	COG0776	regulation of translation
CRN74_RS08220	COG4249	Peptidase C14 caspase catalytic subunit p20
CRN74_RS08225	COG1811	Na channel or pump
CRN74_RS08230	COG1414	Transcriptional regulator
CRN74_RS08235	COG1129	ABC transporter
CRN74_RS08240	COG1172	Belongs to the binding-protein-dependent transport system permease family
CRN74_RS08260	COG1070	Carbohydrate kinase
CRN74_RS08265	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
CRN74_RS08270	COG3623	hexulose-6-phosphate isomerase
CRN74_RS08295	COG0803	Belongs to the bacterial solute-binding protein 9 family
CRN74_RS08300	COG1121	(ABC) transporter
CRN74_RS08305	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CRN74_RS08310	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CRN74_RS08315	COG3001	Fructosamine kinase
CRN74_RS08325	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CRN74_RS08330	COG1917	Cupin 2, conserved barrel domain protein
CRN74_RS08335	COG1028	Short-chain dehydrogenase reductase Sdr
CRN74_RS08350	COG1175	transmembrane transport
CRN74_RS08355	COG0395	ABC-type sugar transport system, permease component
CRN74_RS08360	COG3842	ATPase activity
CRN74_RS08370	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CRN74_RS08375	COG1988	membrane-bound metal-dependent
CRN74_RS08380	COG1823	symporter activity
CRN74_RS08385	COG3023	N-Acetylmuramoyl-L-alanine amidase
CRN74_RS08395	COG0823	Involved in the tonB-independent uptake of proteins
CRN74_RS08400	COG2814	Major facilitator Superfamily
CRN74_RS08405	COG0501	Belongs to the peptidase M48B family
CRN74_RS08410	COG0793	Belongs to the peptidase S41A family
CRN74_RS08415	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
CRN74_RS08420	COG1956	GAF domain-containing protein
CRN74_RS08425	COG2995	paraquat-inducible protein a
CRN74_RS08430	COG3008	intermembrane lipid transfer
CRN74_RS08440	COG2814	Major facilitator Superfamily
CRN74_RS08475	COG3706	GGDEF domain
CRN74_RS08475	COG2203	Gaf domain
CRN74_RS08475	COG4251	negative regulation of phosphorylation
CRN74_RS08475	COG5001	Diguanylate cyclase
CRN74_RS08500	COG0625	glutathione transferase activity
CRN74_RS08535	COG0346	lactoylglutathione lyase activity
CRN74_RS08665	COG3772	lysozyme
CRN74_RS08710	COG4725	Belongs to the MT-A70-like family
CRN74_RS08720	COG2974	May be involved in recombination
CRN74_RS08900	COG1276	copper resistance
CRN74_RS08905	COG2372	response to copper ion
CRN74_RS08910	COG1528	Iron-storage protein
CRN74_RS08925	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CRN74_RS08930	COG1770	oligopeptidase
CRN74_RS08940	COG3097	Belongs to the UPF0267 family
CRN74_RS08945	COG3141	response to X-ray
CRN74_RS08950	COG0513	Belongs to the DEAD box helicase family
CRN74_RS08955	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
CRN74_RS08960	COG3140	Belongs to the UPF0181 family
CRN74_RS08970	COG0494	nUDIX hydrolase
CRN74_RS08975	COG1760	l-serine dehydratase
CRN74_RS08985	COG1253	flavin adenine dinucleotide binding
CRN74_RS08990	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
CRN74_RS08990	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CRN74_RS08995	COG3715	PTS system
CRN74_RS09000	COG3716	PTS system mannose fructose sorbose family IID component
CRN74_RS09010	COG1971	Probably functions as a manganese efflux pump
CRN74_RS09020	COG5002	protein histidine kinase activity
CRN74_RS09020	COG3447	MASE1 domain protein
CRN74_RS09020	COG5001	Diguanylate cyclase
CRN74_RS09035	COG0768	penicillin binding
CRN74_RS09040	COG1496	oxidoreductase activity
CRN74_RS09060	COG1113	amino acid transport
CRN74_RS09095	COG2207	Transcriptional regulator
CRN74_RS09110	COG1132	(ABC) transporter
CRN74_RS09120	COG2203	Gaf domain
CRN74_RS09120	COG3706	GGDEF domain
CRN74_RS09120	COG4251	negative regulation of phosphorylation
CRN74_RS09120	COG5001	Diguanylate cyclase
CRN74_RS09145	COG0697	spore germination
CRN74_RS09150	COG2271	Major facilitator Superfamily
CRN74_RS09155	COG1802	Transcriptional regulator
CRN74_RS09160	COG1063	alcohol dehydrogenase
CRN74_RS09165	COG0246	Mannitol dehydrogenase
CRN74_RS09175	COG1733	regulation of RNA biosynthetic process
CRN74_RS09180	COG0702	epimerase
CRN74_RS09185	COG2873	o-acetylhomoserine
CRN74_RS09195	COG0840	transmembrane signaling receptor activity
CRN74_RS09225	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CRN74_RS09230	COG1737	Transcriptional regulator
CRN74_RS09235	COG3069	C4-dicarboxylate transmembrane transporter activity
CRN74_RS09270	COG3778	Protein conserved in bacteria
CRN74_RS09300	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CRN74_RS09305	COG0322	excinuclease ABC activity
CRN74_RS09310	COG2197	response regulator
CRN74_RS09320	COG3136	membrane protein required for alginate biosynthesis
CRN74_RS09330	COG0366	Alpha amylase catalytic
CRN74_RS09345	COG2264	protein methyltransferase activity
CRN74_RS09355	COG1113	amino acid transport
CRN74_RS09360	COG1309	transcriptional regulator
CRN74_RS09370	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CRN74_RS09375	COG1335	isochorismatase
CRN74_RS09380	COG0251	oxidation-reduction process
CRN74_RS09385	COG2267	carboxylic ester hydrolase activity
CRN74_RS09390	COG0778	Nitroreductase
CRN74_RS09395	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CRN74_RS09400	COG2233	PERMEase
CRN74_RS09405	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
CRN74_RS09425	COG2822	iron ion transport
CRN74_RS09430	COG0672	)-iron permease
CRN74_RS09440	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CRN74_RS09440	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CRN74_RS09440	COG0506	proline dehydrogenase activity
CRN74_RS09455	COG1126	abc transporter atp-binding protein
CRN74_RS09460	COG0765	amino acid transport
CRN74_RS09465	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CRN74_RS09470	COG2515	1-aminocyclopropane-1-carboxylate deaminase
CRN74_RS09480	COG1191	sigma factor activity
CRN74_RS09515	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CRN74_RS09520	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
CRN74_RS09525	COG1677	Flagellar hook-basal body complex protein FliE
CRN74_RS09540	COG1317	bacterial-type flagellum organization
CRN74_RS09545	COG1157	protein secretion by the type III secretion system
CRN74_RS09580	COG1338	Plays a role in the flagellum-specific transport system
CRN74_RS09600	COG1256	bacterial-type flagellum assembly
CRN74_RS09635	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CRN74_RS09640	COG1558	bacterial-type flagellum-dependent cell motility
CRN74_RS09645	COG1815	bacterial-type flagellum-dependent cell motility
CRN74_RS09655	COG2747	anti-sigma28 factor FlgM
CRN74_RS09660	COG3418	PFAM FlgN family protein
CRN74_RS09670	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CRN74_RS09675	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CRN74_RS09680	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
CRN74_RS09685	COG0745	RESPONSE REGULATOR receiver
CRN74_RS09695	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CRN74_RS09700	COG0840	transmembrane signaling receptor activity
CRN74_RS09705	COG0840	transmembrane signaling receptor activity
CRN74_RS09710	COG0835	chemotaxis
CRN74_RS09715	COG0643	Histidine kinase
CRN74_RS09715	COG2198	Histidine kinase
CRN74_RS09740	COG0589	response to stress
CRN74_RS09745	COG2130	NADP-dependent
CRN74_RS09755	COG1285	pathogenesis
CRN74_RS09760	COG0840	transmembrane signaling receptor activity
CRN74_RS09775	COG1609	Transcriptional regulator
CRN74_RS09780	COG3250	beta-galactosidase activity
CRN74_RS09785	COG0604	alcohol dehydrogenase
CRN74_RS09785	COG1028	Short-chain dehydrogenase reductase Sdr
CRN74_RS09785	COG3321	synthase
CRN74_RS09815	COG3228	Belongs to the MtfA family
CRN74_RS09850	COG0583	DNA-binding transcription factor activity
CRN74_RS09875	COG3615	Tellurite resistance protein tehB
CRN74_RS09930	COG3122	Protein conserved in bacteria
CRN74_RS09940	COG0583	DNA-binding transcription factor activity
CRN74_RS09945	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CRN74_RS09950	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CRN74_RS09955	COG0471	metal ion transport
CRN74_RS09965	COG3366	ferrous iron transmembrane transporter activity
CRN74_RS09970	COG0700	Nucleoside recognition
CRN74_RS09990	COG0471	metal ion transport
CRN74_RS10005	COG3051	citrate lyase alpha subunit
CRN74_RS10010	COG2301	Belongs to the HpcH HpaI aldolase family
CRN74_RS10015	COG3052	prosthetic group binding
CRN74_RS10025	COG3290	protein histidine kinase activity
CRN74_RS10030	COG4565	transcriptional regulatory protein
CRN74_RS10045	COG2271	Major facilitator Superfamily
CRN74_RS10050	COG1840	ABC-type Fe3 transport system, periplasmic component
CRN74_RS10060	COG3842	ATPase activity
CRN74_RS10075	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CRN74_RS10075	COG2205	protein histidine kinase activity
CRN74_RS10085	COG3121	Chaperone
CRN74_RS10100	COG3121	Chaperone
CRN74_RS10105	COG1187	pseudouridine synthase activity
CRN74_RS10145	COG3550	peptidyl-serine autophosphorylation
CRN74_RS10150	COG3550	peptidyl-serine autophosphorylation
CRN74_RS10155	COG4221	oxidoreductase activity
CRN74_RS10160	COG0835	chemotaxis
CRN74_RS10160	COG0784	Response regulator, receiver
CRN74_RS10165	COG0534	Mate efflux family protein
CRN74_RS10170	COG0137	argininosuccinate synthase activity
CRN74_RS10175	COG2211	Major facilitator Superfamily
CRN74_RS10180	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
CRN74_RS10190	COG0583	DNA-binding transcription factor activity
CRN74_RS10195	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CRN74_RS10215	COG1492	cobalamin metabolic process
CRN74_RS10280	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
CRN74_RS10290	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
CRN74_RS10365	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
CRN74_RS10375	COG1012	belongs to the aldehyde dehydrogenase family
CRN74_RS10385	COG4656	Part of a membrane complex involved in electron transport
CRN74_RS10405	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CRN74_RS10415	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CRN74_RS10430	COG1129	ABC transporter
CRN74_RS10435	COG1172	Belongs to the binding-protein-dependent transport system permease family
CRN74_RS10445	COG2926	Belongs to the UPF0265 family
CRN74_RS10450	COG1289	transmembrane transporter activity
CRN74_RS10460	COG2925	Exonuclease
CRN74_RS10465	COG0531	amino acid
CRN74_RS10475	COG0371	Dehydrogenase
CRN74_RS10485	COG1172	Belongs to the binding-protein-dependent transport system permease family
CRN74_RS10490	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CRN74_RS10495	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CRN74_RS10500	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CRN74_RS10505	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CRN74_RS10510	COG0131	Imidazoleglycerol-phosphate dehydratase
CRN74_RS10510	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CRN74_RS10520	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CRN74_RS10525	COG0107	imidazoleglycerol-phosphate synthase activity
CRN74_RS10530	COG0140	phosphoribosyl-ATP diphosphatase activity
CRN74_RS10530	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CRN74_RS10535	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CRN74_RS10540	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CRN74_RS10545	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CRN74_RS10565	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
CRN74_RS10575	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CRN74_RS10600	COG1253	flavin adenine dinucleotide binding
CRN74_RS10605	COG3069	C4-dicarboxylate transmembrane transporter activity
CRN74_RS10610	COG2982	Protein involved in outer membrane biogenesis
CRN74_RS10625	COG0489	protein tyrosine kinase activity
CRN74_RS10630	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CRN74_RS10630	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CRN74_RS10645	COG2814	Major facilitator Superfamily
CRN74_RS10650	COG1380	Effector of murein hydrolase LrgA
CRN74_RS10655	COG1346	cytolysis
CRN74_RS10665	COG0281	malic enzyme
CRN74_RS10670	COG2949	membrane
CRN74_RS10680	COG0298	carbon dioxide binding
CRN74_RS10685	COG0375	protein maturation
CRN74_RS10690	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CRN74_RS10695	COG0651	ATP synthesis coupled electron transport
CRN74_RS10700	COG0650	Formate hydrogenlyase subunit 4
CRN74_RS10705	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CRN74_RS10710	COG4237	Hydrogenase 4 membrane
CRN74_RS10715	COG0651	ATP synthesis coupled electron transport
CRN74_RS10720	COG3261	NADH dehydrogenase
CRN74_RS10720	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
CRN74_RS10725	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CRN74_RS10730	COG3260	NADH ubiquinone oxidoreductase 20
CRN74_RS10740	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
CRN74_RS10745	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CRN74_RS10750	COG3383	formate dehydrogenase (NAD+) activity
CRN74_RS10755	COG3604	Transcriptional regulator
CRN74_RS10760	COG2116	formate transmembrane transporter activity
CRN74_RS10785	COG2311	Membrane
CRN74_RS10790	COG0302	gtp cyclohydrolase
CRN74_RS10795	COG0477	Major facilitator Superfamily
CRN74_RS10800	COG0583	DNA-binding transcription factor activity
CRN74_RS10815	COG0477	Major facilitator Superfamily
CRN74_RS10825	COG0303	'Molybdopterin
CRN74_RS10835	COG0488	(ABC) transporter
CRN74_RS10855	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
CRN74_RS10875	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
CRN74_RS10890	COG4106	trans-aconitate 2-methyltransferase activity
CRN74_RS10895	COG0783	Belongs to the Dps family
CRN74_RS10900	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CRN74_RS10905	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CRN74_RS10910	COG0765	amino acid transport
CRN74_RS10915	COG1126	abc transporter atp-binding protein
CRN74_RS10925	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
CRN74_RS10930	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CRN74_RS10945	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CRN74_RS10950	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CRN74_RS10970	COG0697	spore germination
CRN74_RS10980	COG1982	Orn Lys Arg decarboxylase major
CRN74_RS10985	COG0531	amino acid
CRN74_RS10995	COG1174	glycine betaine transport
CRN74_RS11000	COG1125	glycine betaine transport
CRN74_RS11005	COG1174	glycine betaine transport
CRN74_RS11010	COG1732	Glycine betaine
CRN74_RS11025	COG2897	thiosulfate sulfurtransferase activity
CRN74_RS11035	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
CRN74_RS11055	COG4807	Protein conserved in bacteria
CRN74_RS11070	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
CRN74_RS11080	COG2261	transglycosylase associated protein
CRN74_RS11100	COG0277	FAD linked oxidase domain protein
CRN74_RS11105	COG1686	Belongs to the peptidase S11 family
CRN74_RS11115	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CRN74_RS11120	COG0513	Belongs to the DEAD box helicase family
CRN74_RS11125	COG1309	transcriptional regulator
CRN74_RS11130	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CRN74_RS11135	COG1131	(ABC) transporter
CRN74_RS11140	COG0842	Transport permease protein
CRN74_RS11145	COG0842	Transport permease protein
CRN74_RS11150	COG1028	Short-chain dehydrogenase reductase Sdr
CRN74_RS11155	COG3433	isochorismatase activity
CRN74_RS11155	COG1535	isochorismatase
CRN74_RS11160	COG1021	2,3-dihydroxybenzoate-AMP ligase
CRN74_RS11165	COG1169	isochorismate synthase
CRN74_RS11170	COG4592	Periplasmic binding protein
CRN74_RS11180	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CRN74_RS11195	COG4774	siderophore transport
CRN74_RS11200	COG0670	Belongs to the BI1 family
CRN74_RS11205	COG0314	molybdopterin synthase activity
CRN74_RS11210	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
CRN74_RS11215	COG0315	cyclic pyranopterin monophosphate synthase activity
CRN74_RS11220	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CRN74_RS11225	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CRN74_RS11230	COG4628	conserved protein (DUF2132)
CRN74_RS11235	COG0556	nucleotide-excision repair
CRN74_RS11250	COG2226	methyltransferase
CRN74_RS11255	COG0156	8-amino-7-oxononanoate synthase activity
CRN74_RS11260	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CRN74_RS11270	COG2706	6-phosphogluconolactonase activity
CRN74_RS11275	COG0561	phosphatase activity
CRN74_RS11280	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
CRN74_RS11285	COG0622	Phosphoesterase
CRN74_RS11295	COG1090	epimerase
CRN74_RS11300	COG4598	ABC transporter
CRN74_RS11305	COG4160	amino acid transport
CRN74_RS11310	COG4215	(ABC) transporter
CRN74_RS11315	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CRN74_RS11325	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CRN74_RS11330	COG1286	toxin biosynthetic process
CRN74_RS11335	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
CRN74_RS11340	COG0285	dihydrofolate synthase activity
CRN74_RS11345	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CRN74_RS11350	COG0586	Pfam SNARE associated Golgi protein
CRN74_RS11360	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CRN74_RS11380	COG1017	nitric oxide dioxygenase activity
CRN74_RS11380	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CRN74_RS11385	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CRN74_RS11395	COG4232	protein-disulfide reductase activity
CRN74_RS11410	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CRN74_RS11420	COG1794	racemase activity, acting on amino acids and derivatives
CRN74_RS11430	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CRN74_RS11435	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
CRN74_RS11435	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CRN74_RS11445	COG3101	peptidyl-lysine hydroxylation
CRN74_RS11450	COG0730	response to heat
CRN74_RS11455	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
CRN74_RS11465	COG2890	protein-(glutamine-N5) methyltransferase activity
CRN74_RS11475	COG2840	Smr protein MutS2
CRN74_RS11485	COG2062	phosphohistidine phosphatase, SixA
CRN74_RS11495	COG1250	3-hydroxyacyl-CoA dehydrogenase
CRN74_RS11495	COG1024	Enoyl-CoA hydratase
CRN74_RS11500	COG0183	Belongs to the thiolase family
CRN74_RS11505	COG3691	Protein conserved in bacteria
CRN74_RS11530	COG4235	cytochrome complex assembly
CRN74_RS11530	COG3088	subunit of a heme lyase
CRN74_RS11535	COG4235	cytochrome complex assembly
CRN74_RS11535	COG3088	subunit of a heme lyase
CRN74_RS11540	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CRN74_RS11545	COG1138	Cytochrome C-type biogenesis protein
CRN74_RS11550	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
CRN74_RS11555	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CRN74_RS11560	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CRN74_RS11565	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CRN74_RS11575	COG2116	formate transmembrane transporter activity
CRN74_RS11585	COG0582	viral genome integration into host DNA
CRN74_RS11750	COG3772	lysozyme
CRN74_RS11825	COG0305	Participates in initiation and elongation during chromosome replication
CRN74_RS11970	COG0243	molybdopterin cofactor binding
CRN74_RS11975	COG3005	denitrification pathway
CRN74_RS11980	COG2197	response regulator
CRN74_RS11985	COG2223	nitrite transmembrane transporter activity
CRN74_RS11990	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
CRN74_RS11995	COG1140	nitrate reductase beta subunit
CRN74_RS12000	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
CRN74_RS12005	COG2181	nitrate reductase activity
CRN74_RS12010	COG2197	response regulator
CRN74_RS12015	COG0784	Response regulator, receiver
CRN74_RS12015	COG2198	Histidine kinase
CRN74_RS12015	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CRN74_RS12015	COG2205	protein histidine kinase activity
CRN74_RS12025	COG2095	MarC family integral membrane protein
CRN74_RS12040	COG0531	amino acid
CRN74_RS12045	COG0076	glutamate decarboxylase activity
CRN74_RS12050	COG2226	methyltransferase
CRN74_RS12055	COG2824	Alkylphosphonate utilization operon protein PhnA
CRN74_RS12060	COG1695	Transcriptional regulator
CRN74_RS12070	COG2723	6-phospho-beta-galactosidase activity
CRN74_RS12075	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CRN74_RS12075	COG1263	PTS System
CRN74_RS12080	COG1609	Transcriptional regulator
CRN74_RS12085	COG2353	YceI-like domain
CRN74_RS12090	COG3038	cytochrome b561
CRN74_RS12105	COG1127	ABC transporter
CRN74_RS12110	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CRN74_RS12130	COG0531	amino acid
CRN74_RS12135	COG2951	lytic endotransglycosylase activity
CRN74_RS12150	COG0243	molybdopterin cofactor binding
CRN74_RS12155	COG0437	4 iron, 4 sulfur cluster binding
CRN74_RS12160	COG3302	dmso reductase anchor subunit
CRN74_RS12190	COG0406	alpha-ribazole phosphatase activity
CRN74_RS12210	COG1598	PFAM Uncharacterised protein family UPF0150
CRN74_RS12220	COG3038	cytochrome b561
CRN74_RS12225	COG0436	Aminotransferase
CRN74_RS12240	COG3275	phosphorelay sensor kinase activity
CRN74_RS12245	COG3279	Response regulator of the LytR AlgR family
CRN74_RS12250	COG2223	nitrite transmembrane transporter activity
CRN74_RS12260	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
CRN74_RS12265	COG0837	glucose binding
CRN74_RS12280	COG3961	Belongs to the TPP enzyme family
CRN74_RS12285	COG0667	Aldo Keto reductase
CRN74_RS12295	COG1914	H( )-stimulated, divalent metal cation uptake system
CRN74_RS12305	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CRN74_RS12350	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CRN74_RS12380	COG3530	Putative quorum-sensing-regulated virulence factor
CRN74_RS12385	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CRN74_RS12395	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
CRN74_RS12405	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CRN74_RS12420	COG2205	protein histidine kinase activity
CRN74_RS12425	COG0745	RESPONSE REGULATOR receiver
CRN74_RS12430	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CRN74_RS12460	COG1216	Glycosyl transferase, family 2
CRN74_RS12495	COG4208	sulfate ABC transporter
CRN74_RS12500	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
CRN74_RS12515	COG1737	Transcriptional regulator
CRN74_RS12520	COG2731	YhcH YjgK YiaL family protein
CRN74_RS12535	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CRN74_RS12540	COG2837	iron assimilation
CRN74_RS12550	COG3111	PFAM Bacterial OB fold (BOF) protein
CRN74_RS12555	COG1028	Short-chain dehydrogenase reductase Sdr
CRN74_RS12580	COG1172	Belongs to the binding-protein-dependent transport system permease family
CRN74_RS12585	COG1129	ABC transporter
CRN74_RS12605	COG0456	acetyltransferase
CRN74_RS12610	COG0408	coproporphyrinogen oxidase activity
CRN74_RS12625	COG0494	nUDIX hydrolase
CRN74_RS12630	COG3005	denitrification pathway
CRN74_RS12635	COG3043	anaerobic respiration
CRN74_RS12640	COG0243	molybdopterin cofactor binding
CRN74_RS12645	COG3062	negative regulation of establishment of protein localization
CRN74_RS12650	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
CRN74_RS12650	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CRN74_RS12655	COG2197	response regulator
CRN74_RS12665	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CRN74_RS12685	COG3842	ATPase activity
CRN74_RS12690	COG1175	transmembrane transport
CRN74_RS12705	COG2197	response regulator
CRN74_RS12710	COG0583	DNA-binding transcription factor activity
CRN74_RS12715	COG1393	Belongs to the ArsC family
CRN74_RS12720	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CRN74_RS12725	COG1876	peptidase activity
CRN74_RS12735	COG0400	carboxylic ester hydrolase activity
CRN74_RS12740	COG1444	tRNA N-acetyltransferase activity
CRN74_RS12745	COG2707	UPF0756 membrane protein
CRN74_RS12750	COG2321	neutral zinc metallopeptidase
CRN74_RS12755	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CRN74_RS12760	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
CRN74_RS12765	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CRN74_RS12770	COG2716	regulation of RNA biosynthetic process
CRN74_RS12775	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CRN74_RS12780	COG0628	permease
CRN74_RS12785	COG4783	chaperone-mediated protein folding
CRN74_RS12790	COG1393	Belongs to the ArsC family
CRN74_RS12795	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CRN74_RS12800	COG2233	PERMEase
CRN74_RS12805	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CRN74_RS12815	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CRN74_RS12820	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CRN74_RS12830	COG0581	inorganic phosphate transmembrane transporter activity
CRN74_RS12840	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CRN74_RS12855	COG2239	Acts as a magnesium transporter
CRN74_RS12860	COG5002	protein histidine kinase activity
CRN74_RS12860	COG3447	MASE1 domain protein
CRN74_RS12860	COG5001	Diguanylate cyclase
CRN74_RS12865	COG0443	Heat shock 70 kDa protein
CRN74_RS12875	COG3121	Chaperone
CRN74_RS12890	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CRN74_RS12900	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CRN74_RS12905	COG0477	Major facilitator Superfamily
CRN74_RS12910	COG2205	protein histidine kinase activity
CRN74_RS12915	COG0745	RESPONSE REGULATOR receiver
CRN74_RS12920	COG3422	double-strand break repair
CRN74_RS12925	COG0826	peptidase U32
CRN74_RS12930	COG1597	lipid kinase activity
CRN74_RS12935	COG3730	PTS system glucitol sorbitol-specific
CRN74_RS12950	COG1028	Short-chain dehydrogenase reductase Sdr
CRN74_RS12955	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
CRN74_RS12960	COG1349	DNA-binding transcription factor activity
CRN74_RS12980	COG0351	phosphomethylpyrimidine kinase
CRN74_RS12995	COG3121	Chaperone
CRN74_RS13000	COG3121	Chaperone
CRN74_RS13010	COG3121	Chaperone
CRN74_RS13025	COG2197	response regulator
CRN74_RS13035	COG3710	Transcriptional regulator
CRN74_RS13045	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CRN74_RS13045	COG0519	Catalyzes the synthesis of GMP from XMP
CRN74_RS13050	COG0516	GMP reductase activity
CRN74_RS13050	COG0517	IMP dehydrogenase activity
CRN74_RS13055	COG1570	exodeoxyribonuclease VII activity
CRN74_RS13060	COG1645	bacterial-type flagellum-dependent swarming motility
CRN74_RS13070	COG1160	GTP binding
CRN74_RS13075	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CRN74_RS13080	COG2976	Protein conserved in bacteria
CRN74_RS13095	COG1426	Protein conserved in bacteria
CRN74_RS13120	COG4953	penicillin-binding protein 1C
CRN74_RS13125	COG2373	Large extracellular alpha-helical protein
CRN74_RS13130	COG3468	outer membrane autotransporter barrel domain protein
CRN74_RS13145	COG2975	iron-sulfur cluster assembly
CRN74_RS13150	COG0633	Ferredoxin
CRN74_RS13155	COG0443	Heat shock 70 kDa protein
CRN74_RS13160	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CRN74_RS13170	COG0822	iron-sulfur transferase activity
CRN74_RS13180	COG1959	2 iron, 2 sulfur cluster binding
CRN74_RS13185	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
CRN74_RS13190	COG0483	inositol monophosphate 1-phosphatase activity
CRN74_RS13195	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
CRN74_RS13200	COG3683	transport system, periplasmic component
CRN74_RS13205	COG3711	transcriptional antiterminator
CRN74_RS13210	COG2814	Major facilitator Superfamily
CRN74_RS13220	COG1017	nitric oxide dioxygenase activity
CRN74_RS13220	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CRN74_RS13225	COG2188	Transcriptional regulator
CRN74_RS13230	COG2188	Transcriptional regulator
CRN74_RS13240	COG3457	Alanine racemase
CRN74_RS13245	COG1735	metal-dependent hydrolase with the TIM-barrel fold
CRN74_RS13260	COG0347	Belongs to the P(II) protein family
CRN74_RS13265	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CRN74_RS13265	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CRN74_RS13270	COG2204	response regulator
CRN74_RS13275	COG3170	Tfp pilus assembly protein FimV
CRN74_RS13280	COG2205	protein histidine kinase activity
CRN74_RS13295	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
CRN74_RS13305	COG0560	Phosphoserine phosphatase
CRN74_RS13310	COG1737	Transcriptional regulator
CRN74_RS13315	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CRN74_RS13320	COG0736	holo-[acyl-carrier-protein] synthase activity
CRN74_RS13325	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CRN74_RS13330	COG1381	Involved in DNA repair and RecF pathway recombination
CRN74_RS13360	COG3086	response to oxidative stress
CRN74_RS13365	COG3026	antisigma factor binding
CRN74_RS13380	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CRN74_RS13385	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CRN74_RS13390	COG0513	Belongs to the DEAD box helicase family
CRN74_RS13395	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
CRN74_RS13400	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CRN74_RS13405	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CRN74_RS13410	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CRN74_RS13415	COG0497	DNA recombination
CRN74_RS13420	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CRN74_RS13430	COG2867	negative regulation of translational initiation
CRN74_RS13435	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CRN74_RS13470	COG3778	Protein conserved in bacteria
CRN74_RS13475	COG3299	homolog of phage Mu protein gp47
CRN74_RS13525	COG4386	tail sheath protein
CRN74_RS13565	COG0740	serine-type endopeptidase activity
CRN74_RS13575	COG4626	Terminase
CRN74_RS13575	COG1802	Transcriptional regulator
CRN74_RS13630	COG0305	Participates in initiation and elongation during chromosome replication
CRN74_RS13635	COG1484	DNA-dependent DNA replication
CRN74_RS13750	COG0582	viral genome integration into host DNA
CRN74_RS13755	COG0582	viral genome integration into host DNA
CRN74_RS13770	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CRN74_RS13775	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CRN74_RS13810	COG2963	transposase activity
CRN74_RS13815	COG3311	Transcriptional regulator
CRN74_RS13820	COG4983	Phage plasmid primase, P4 family domain protein
CRN74_RS13850	COG2003	Belongs to the UPF0758 family
CRN74_RS13870	COG0563	adenylate kinase activity
CRN74_RS13875	COG0251	oxidation-reduction process
CRN74_RS13890	COG0789	Transcriptional regulator
CRN74_RS13905	COG1120	ATPase activity
CRN74_RS13910	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CRN74_RS13915	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CRN74_RS13920	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
CRN74_RS13925	COG4772	TonB-dependent receptor
CRN74_RS13930	COG3712	iron ion homeostasis
CRN74_RS13935	COG1595	DNA-templated transcription, initiation
CRN74_RS13945	COG3394	polysaccharide catabolic process
CRN74_RS13950	COG1917	Cupin 2, conserved barrel domain protein
CRN74_RS13950	COG2169	Transcriptional regulator
CRN74_RS13955	COG1447	Phosphotransferase system cellobiose-specific component IIA
CRN74_RS13960	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CRN74_RS13965	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CRN74_RS13970	COG2133	pyrroloquinoline quinone binding
CRN74_RS13985	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CRN74_RS13995	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
CRN74_RS14000	COG4413	Urea transporter
CRN74_RS14010	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CRN74_RS14020	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
CRN74_RS14025	COG0804	urea catabolic process
CRN74_RS14030	COG0832	Belongs to the urease beta subunit family
CRN74_RS14035	COG0831	urea catabolic process
CRN74_RS14050	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CRN74_RS14055	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CRN74_RS14065	COG0747	negative chemotaxis
CRN74_RS14090	COG4575	ribosome binding
CRN74_RS14100	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CRN74_RS14110	COG1780	Probably involved in ribonucleotide reductase function
CRN74_RS14120	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CRN74_RS14130	COG4176	ABC-type proline glycine betaine transport system permease component
CRN74_RS14135	COG2113	Glycine betaine
CRN74_RS14145	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CRN74_RS14155	COG2226	methyltransferase
CRN74_RS14160	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CRN74_RS14165	COG0741	lytic transglycosylase activity
CRN74_RS14165	COG1388	LysM domain
CRN74_RS14170	COG3021	interspecies interaction between organisms
CRN74_RS14175	COG0656	L-ascorbic acid biosynthetic process
CRN74_RS14180	COG0583	DNA-binding transcription factor activity
CRN74_RS14185	COG2814	Major facilitator Superfamily
CRN74_RS14220	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CRN74_RS14230	COG2011	ABC-type metal ion transport system permease component
CRN74_RS14235	COG1464	Belongs to the NlpA lipoprotein family
CRN74_RS14245	COG1720	tRNA m6t6A37 methyltransferase activity
CRN74_RS14250	COG0442	prolyl-tRNA aminoacylation
CRN74_RS14255	COG3015	lipoprotein NlpE involved in copper resistance
CRN74_RS14265	COG4681	YaeQ
CRN74_RS14275	COG4568	rho-dependent transcription termination
CRN74_RS14290	COG0346	lactoylglutathione lyase activity
CRN74_RS14295	COG0825	malonyl-CoA metabolic process
CRN74_RS14300	COG0587	DNA-directed DNA polymerase activity
CRN74_RS14305	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CRN74_RS14315	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CRN74_RS14325	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CRN74_RS14330	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
CRN74_RS14340	COG0750	zinc metalloprotease
CRN74_RS14345	COG0575	Belongs to the CDS family
CRN74_RS14355	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CRN74_RS14365	COG0528	UMP kinase activity
CRN74_RS14370	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CRN74_RS14385	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
CRN74_RS14390	COG2171	N-acyltransferase activity
CRN74_RS14410	COG0564	pseudouridine synthase activity
CRN74_RS14415	COG3098	single-species biofilm formation
CRN74_RS14425	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CRN74_RS14425	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CRN74_RS14430	COG1611	Belongs to the LOG family
CRN74_RS14440	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
CRN74_RS14445	COG2363	Small membrane protein
CRN74_RS14450	COG0583	DNA-binding transcription factor activity
CRN74_RS14460	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CRN74_RS14465	COG2166	iron-sulfur cluster assembly
CRN74_RS14470	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CRN74_RS14475	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
CRN74_RS14495	COG0860	N-Acetylmuramoyl-L-alanine amidase
CRN74_RS14500	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CRN74_RS14500	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
CRN74_RS14505	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CRN74_RS14510	COG1074	ATP-dependent DNA helicase activity
CRN74_RS14515	COG1025	Belongs to the peptidase M16 family
CRN74_RS14520	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
CRN74_RS14540	COG2165	general secretion pathway protein
CRN74_RS14550	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CRN74_RS14560	COG1051	belongs to the nudix hydrolase family
CRN74_RS14570	COG3066	DNA modification
CRN74_RS14575	COG0861	Integral membrane protein TerC family
CRN74_RS14580	COG0667	Aldo Keto reductase
CRN74_RS14585	COG5499	transcription regulator containing HTH domain
CRN74_RS14590	COG0477	Major facilitator Superfamily
CRN74_RS14595	COG0204	Acyl-transferase
CRN74_RS14595	COG0318	PFAM AMP-dependent synthetase and ligase
CRN74_RS14605	COG1609	Transcriptional regulator
CRN74_RS14620	COG0583	DNA-binding transcription factor activity
CRN74_RS14625	COG2814	Major facilitator Superfamily
CRN74_RS14630	COG0583	DNA-binding transcription factor activity
CRN74_RS14670	COG1733	regulation of RNA biosynthetic process
CRN74_RS14675	COG1028	Short-chain dehydrogenase reductase Sdr
CRN74_RS14685	COG0484	heat shock protein binding
CRN74_RS14695	COG2271	Major facilitator Superfamily
CRN74_RS14710	COG1522	sequence-specific DNA binding
CRN74_RS14715	COG3706	GGDEF domain
CRN74_RS14735	COG0656	L-ascorbic acid biosynthetic process
CRN74_RS14755	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CRN74_RS14760	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CRN74_RS14765	COG4974	Belongs to the 'phage' integrase family
CRN74_RS14770	COG0716	FMN binding
CRN74_RS14775	COG4452	Inner membrane protein CreD
CRN74_RS14780	COG2205	protein histidine kinase activity
CRN74_RS14785	COG0745	RESPONSE REGULATOR receiver
CRN74_RS14800	COG0354	folic acid binding
CRN74_RS14805	COG1272	protein, Hemolysin III
CRN74_RS14810	COG1028	Short-chain dehydrogenase reductase Sdr
CRN74_RS14815	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CRN74_RS14815	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CRN74_RS14820	COG0509	glycine decarboxylation via glycine cleavage system
CRN74_RS14825	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CRN74_RS14830	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CRN74_RS14835	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CRN74_RS14840	COG0006	proline dipeptidase activity
CRN74_RS14845	COG3079	Belongs to the UPF0149 family
CRN74_RS14850	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
CRN74_RS14860	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CRN74_RS14865	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CRN74_RS14870	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CRN74_RS14875	COG0583	DNA-binding transcription factor activity
CRN74_RS14885	COG1279	arginine transmembrane transporter activity
CRN74_RS14900	COG0191	fructose-bisphosphate aldolase activity
CRN74_RS14905	COG0126	phosphoglycerate kinase activity
CRN74_RS14910	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CRN74_RS14915	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CRN74_RS14920	COG0501	Belongs to the peptidase M48B family
CRN74_RS14935	COG1166	arginine decarboxylase activity
CRN74_RS14940	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CRN74_RS14955	COG0640	Transcriptional regulator
CRN74_RS14960	COG3091	SprT-like family
CRN74_RS14965	COG2356	endonuclease I
CRN74_RS14970	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CRN74_RS14975	COG0189	ligase activity
CRN74_RS14980	COG1678	Uncharacterized ACR, COG1678
CRN74_RS14985	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CRN74_RS14990	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CRN74_RS15000	COG2805	Type II/IV secretion system protein
CRN74_RS15005	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CRN74_RS15010	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CRN74_RS15015	COG0762	integral membrane protein
CRN74_RS15020	COG1872	DUF167
CRN74_RS15025	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CRN74_RS15030	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CRN74_RS15045	COG3171	Protein conserved in bacteria
CRN74_RS15050	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CRN74_RS15055	COG1194	a g-specific adenine glycosylase
CRN74_RS15065	COG0741	lytic transglycosylase activity
CRN74_RS15070	COG1982	Orn Lys Arg decarboxylase major
CRN74_RS15090	COG3188	usher protein
CRN74_RS15095	COG3121	Chaperone
CRN74_RS15110	COG3655	Transcriptional regulator
CRN74_RS15125	COG0583	DNA-binding transcription factor activity
CRN74_RS15130	COG0814	amino acid
CRN74_RS15135	COG0626	cystathionine gamma-synthase activity
CRN74_RS15140	COG1082	Xylose isomerase domain protein TIM barrel
CRN74_RS15145	COG1653	transport
CRN74_RS15150	COG0823	Involved in the tonB-independent uptake of proteins
CRN74_RS15155	COG0673	inositol 2-dehydrogenase activity
CRN74_RS15170	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CRN74_RS15200	COG0745	RESPONSE REGULATOR receiver
CRN74_RS15215	COG1987	bacterial-type flagellum assembly
CRN74_RS15230	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CRN74_RS15240	COG1580	Controls the rotational direction of flagella during chemotaxis
CRN74_RS15245	COG3144	bacterial-type flagellum assembly
CRN74_RS15255	COG1157	protein secretion by the type III secretion system
CRN74_RS15260	COG1317	bacterial-type flagellum organization
CRN74_RS15270	COG1766	The M ring may be actively involved in energy transduction
CRN74_RS15275	COG1677	Flagellar hook-basal body complex protein FliE
CRN74_RS15280	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CRN74_RS15290	COG0745	RESPONSE REGULATOR receiver
CRN74_RS15300	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CRN74_RS15350	COG0835	chemotaxis
CRN74_RS15355	COG2198	Histidine kinase
CRN74_RS15355	COG0643	Histidine kinase
CRN74_RS15380	COG1191	sigma factor activity
CRN74_RS15385	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CRN74_RS15425	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CRN74_RS15435	COG1815	bacterial-type flagellum-dependent cell motility
CRN74_RS15445	COG2747	anti-sigma28 factor FlgM
CRN74_RS15470	COG2197	response regulator
CRN74_RS15475	COG0840	transmembrane signaling receptor activity
CRN74_RS15505	COG1388	LysM domain
CRN74_RS15505	COG2373	Large extracellular alpha-helical protein
CRN74_RS15505	COG4932	domain protein
CRN74_RS15530	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CRN74_RS15580	COG4964	Belongs to the GSP D family
CRN74_RS15650	COG1289	transmembrane transporter activity
CRN74_RS15665	COG1228	amidohydrolase
CRN74_RS15725	COG1388	LysM domain
CRN74_RS15725	COG0791	NLP P60 protein
CRN74_RS15755	COG2885	chlorophyll binding
CRN74_RS15810	COG3210	domain, Protein
CRN74_RS15815	COG2831	hemolysin activation secretion protein
CRN74_RS15820	COG1124	(ABC) transporter
CRN74_RS15825	COG0444	Belongs to the ABC transporter superfamily
CRN74_RS15830	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CRN74_RS15835	COG0601	transmembrane transport
CRN74_RS15840	COG0747	negative chemotaxis
CRN74_RS15845	COG2226	methyltransferase
CRN74_RS15850	COG1349	DNA-binding transcription factor activity
CRN74_RS15865	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CRN74_RS15875	COG3716	PTS system mannose fructose sorbose family IID component
CRN74_RS15880	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
CRN74_RS15885	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CRN74_RS15890	COG2222	sugar isomerase
CRN74_RS15910	COG0024	Methionine aminopeptidase
CRN74_RS15915	COG4604	ABC transporter, ATP-binding protein
CRN74_RS15920	COG4605	iron ion homeostasis
CRN74_RS15930	COG4607	ABC-type enterochelin transport system periplasmic component
CRN74_RS15935	COG0477	Major facilitator Superfamily
CRN74_RS15940	COG1609	Transcriptional regulator
CRN74_RS15965	COG0477	Major facilitator Superfamily
CRN74_RS15970	COG4302	ethanolamine ammonia-lyase activity
CRN74_RS15975	COG4303	Ethanolamine ammonia lyase large subunit
CRN74_RS15990	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CRN74_RS16000	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
CRN74_RS16005	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
CRN74_RS16010	COG0471	metal ion transport
CRN74_RS16015	COG5001	Diguanylate cyclase
CRN74_RS16025	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
CRN74_RS16030	COG0309	Hydrogenase expression formation protein (HypE)
CRN74_RS16035	COG0409	Hydrogenase expression formation protein
CRN74_RS16040	COG0298	carbon dioxide binding
CRN74_RS16045	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CRN74_RS16055	COG1773	rubredoxin
CRN74_RS16060	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
CRN74_RS16065	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
CRN74_RS16070	COG5557	Pfam Polysulphide reductase, NrfD
CRN74_RS16075	COG0437	4 iron, 4 sulfur cluster binding
CRN74_RS16080	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
CRN74_RS16085	COG3133	Outer membrane lipoprotein
CRN74_RS16100	COG0840	transmembrane signaling receptor activity
CRN74_RS16105	COG4592	Periplasmic binding protein
CRN74_RS16115	COG1609	Transcriptional regulator
CRN74_RS16135	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CRN74_RS16140	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CRN74_RS16145	COG1120	ATPase activity
CRN74_RS16170	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CRN74_RS16175	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CRN74_RS16200	COG4964	Belongs to the GSP D family
CRN74_RS16250	COG0848	biopolymer transport protein
CRN74_RS16260	COG0626	cystathionine gamma-synthase activity
CRN74_RS16265	COG0586	Pfam SNARE associated Golgi protein
CRN74_RS16270	COG2207	Transcriptional regulator
CRN74_RS16275	COG1979	alcohol dehydrogenase
CRN74_RS16280	COG0656	L-ascorbic acid biosynthetic process
CRN74_RS16290	COG2132	Multicopper oxidase
CRN74_RS16300	COG0204	Acyl-transferase
CRN74_RS16310	COG2249	NAD(P)H dehydrogenase (quinone) activity
CRN74_RS16315	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
CRN74_RS16335	COG3150	esterase
CRN74_RS16340	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CRN74_RS16345	COG3151	Protein conserved in bacteria
CRN74_RS16350	COG0494	nUDIX hydrolase
CRN74_RS16355	COG1538	Outer membrane efflux protein
CRN74_RS16360	COG5463	Belongs to the UPF0441 family
CRN74_RS16365	COG0754	glutathionylspermidine amidase activity
CRN74_RS16370	COG3384	dioxygenase
CRN74_RS16375	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CRN74_RS16385	COG0531	amino acid
CRN74_RS16390	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
CRN74_RS16390	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CRN74_RS16395	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
CRN74_RS16400	COG3025	triphosphatase activity
CRN74_RS16405	COG4991	sh3 domain protein
CRN74_RS16410	COG0617	tRNA 3'-terminal CCA addition
CRN74_RS16415	COG1968	undecaprenyl-diphosphatase activity
CRN74_RS16420	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CRN74_RS16425	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CRN74_RS16430	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CRN74_RS16435	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CRN74_RS16440	COG0358	DNA primase activity
CRN74_RS16460	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CRN74_RS16465	COG1454	alcohol dehydrogenase
CRN74_RS16480	COG2271	Major facilitator Superfamily
CRN74_RS16485	COG0800	Aldolase
CRN74_RS16495	COG3247	response to pH
CRN74_RS16500	COG0446	pyridine nucleotide-disulphide oxidoreductase
CRN74_RS16500	COG1902	pentaerythritol trinitrate reductase activity
CRN74_RS16510	COG2813	Specifically methylates the guanine in position
CRN74_RS16515	COG1451	nucleotide metabolic process
CRN74_RS16520	COG0673	inositol 2-dehydrogenase activity
CRN74_RS16525	COG0861	Integral membrane protein TerC family
CRN74_RS16530	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
CRN74_RS16540	COG2721	sulfolactate sulfo-lyase activity
CRN74_RS16545	COG0246	Mannitol dehydrogenase
CRN74_RS16550	COG1904	glucuronate isomerase
CRN74_RS16555	COG2271	Major facilitator Superfamily
CRN74_RS16570	COG0586	Pfam SNARE associated Golgi protein
CRN74_RS16585	COG4575	ribosome binding
CRN74_RS16590	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
CRN74_RS16600	COG2259	Doxx family
CRN74_RS16605	COG0435	Glutathione S-transferase
CRN74_RS16610	COG0583	DNA-binding transcription factor activity
CRN74_RS16615	COG1741	Belongs to the pirin family
CRN74_RS16620	COG1064	alcohol dehydrogenase
CRN74_RS16655	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CRN74_RS16665	COG0792	nuclease activity
CRN74_RS16670	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
CRN74_RS16675	COG2823	Periplasmic or secreted lipoprotein
CRN74_RS16680	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CRN74_RS16685	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
CRN74_RS16690	COG0784	Response regulator, receiver
CRN74_RS16690	COG2198	Histidine kinase
CRN74_RS16690	COG5002	protein histidine kinase activity
CRN74_RS16695	COG1242	4 iron, 4 sulfur cluster binding
CRN74_RS16700	COG0070	glutamate synthase
CRN74_RS16700	COG0069	glutamate synthase activity
CRN74_RS16700	COG0067	glutamate synthase
CRN74_RS16705	COG0493	'glutamate synthase
CRN74_RS16715	COG2969	positive regulation of protein catabolic process
CRN74_RS16720	COG0625	glutathione transferase activity
CRN74_RS16730	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CRN74_RS16735	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CRN74_RS16740	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
CRN74_RS16745	COG3105	Protein conserved in bacteria
CRN74_RS16750	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CRN74_RS16755	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CRN74_RS16760	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CRN74_RS16765	COG5007	Belongs to the BolA IbaG family
CRN74_RS16770	COG3113	response to antibiotic
CRN74_RS16775	COG2854	intermembrane phospholipid transfer
CRN74_RS16780	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CRN74_RS16785	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CRN74_RS16790	COG1127	ABC transporter
CRN74_RS16795	COG0530	calcium, potassium:sodium antiporter activity
CRN74_RS16800	COG0517	IMP dehydrogenase activity
CRN74_RS16800	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CRN74_RS16805	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
CRN74_RS16810	COG3117	lipopolysaccharide transmembrane transporter activity
CRN74_RS16815	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
CRN74_RS16820	COG1137	ATPase activity
CRN74_RS16825	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CRN74_RS16845	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CRN74_RS16850	COG0540	Belongs to the ATCase OTCase family
CRN74_RS16855	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
CRN74_RS16865	COG2308	Evidence 4 Homologs of previously reported genes of
CRN74_RS16895	COG0366	Alpha amylase catalytic
CRN74_RS16900	COG1263	PTS System
CRN74_RS16900	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CRN74_RS16905	COG1609	Transcriptional regulator
CRN74_RS16920	COG3711	transcriptional antiterminator
CRN74_RS16920	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CRN74_RS16935	COG3964	amidohydrolase
CRN74_RS16965	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CRN74_RS16970	COG3783	Cytochrome b(562)
CRN74_RS16980	COG0312	modulator of DNA gyrase
CRN74_RS16985	COG3028	Belongs to the UPF0307 family
CRN74_RS16990	COG2732	(Barnase) inhibitor
CRN74_RS17005	COG1289	transmembrane transporter activity
CRN74_RS17010	COG1566	PFAM secretion protein HlyD family protein
CRN74_RS17020	COG0583	DNA-binding transcription factor activity
CRN74_RS17045	COG0312	modulator of DNA gyrase
CRN74_RS17050	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CRN74_RS17055	COG3164	Protein of unknown function
CRN74_RS17060	COG1530	ribonuclease E activity
CRN74_RS17065	COG0424	maF-like protein
CRN74_RS17070	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
CRN74_RS17075	COG1792	Involved in formation and maintenance of cell shape
CRN74_RS17080	COG1077	Cell shape determining protein MreB Mrl
CRN74_RS17085	COG2200	EAL domain
CRN74_RS17085	COG2199	diguanylate cyclase activity
CRN74_RS17090	COG0604	alcohol dehydrogenase
CRN74_RS17100	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
CRN74_RS17110	COG0511	ligase activity, forming carbon-carbon bonds
CRN74_RS17115	COG0439	Biotin carboxylase
CRN74_RS17120	COG3924	membrane
CRN74_RS17125	COG4145	pantothenate transmembrane transporter activity
CRN74_RS17130	COG2264	protein methyltransferase activity
CRN74_RS17135	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CRN74_RS17140	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
CRN74_RS17155	COG3133	Outer membrane lipoprotein
CRN74_RS17165	COG1278	Cold shock
CRN74_RS17170	COG1278	Cold shock
CRN74_RS17175	COG0471	metal ion transport
CRN74_RS17185	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CRN74_RS17195	COG1172	Belongs to the binding-protein-dependent transport system permease family
CRN74_RS17200	COG1129	ABC transporter
CRN74_RS17210	COG1560	Kdo2-lipid A biosynthetic process
CRN74_RS17220	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CRN74_RS17225	COG4597	amino acid ABC transporter
CRN74_RS17230	COG0765	amino acid transport
CRN74_RS17235	COG1126	abc transporter atp-binding protein
CRN74_RS17245	COG1380	Effector of murein hydrolase LrgA
CRN74_RS17250	COG0583	DNA-binding transcription factor activity
CRN74_RS17255	COG0025	NhaP-type Na H and K H
CRN74_RS17260	COG2252	PERMEase
CRN74_RS17280	COG0629	single-stranded DNA binding
CRN74_RS17285	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CRN74_RS17290	COG2315	Protein conserved in bacteria
CRN74_RS17295	COG1448	Aminotransferase
CRN74_RS17320	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CRN74_RS17330	COG0735	belongs to the Fur family
CRN74_RS17335	COG3237	CsbD-like
CRN74_RS17340	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CRN74_RS17345	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CRN74_RS17350	COG2937	Belongs to the GPAT DAPAT family
CRN74_RS17360	COG3161	chorismate lyase activity
CRN74_RS17370	COG4580	involved in the transport of maltose and maltodextrins
CRN74_RS17385	COG2182	Extracellular solute-binding protein
CRN74_RS17390	COG1175	transmembrane transport
CRN74_RS17395	COG3833	ABC-type maltose transport systems, permease component
CRN74_RS17410	COG0527	aspartate kinase activity
CRN74_RS17420	COG1410	methionine synthase
CRN74_RS17420	COG0646	methionine synthase
CRN74_RS17425	COG1414	Transcriptional regulator
CRN74_RS17430	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
CRN74_RS17435	COG2224	Isocitrate lyase
CRN74_RS17440	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CRN74_RS17445	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
CRN74_RS17480	COG0151	Belongs to the GarS family
CRN74_RS17500	COG1515	deoxyribonuclease V activity
CRN74_RS17510	COG2816	NAD+ diphosphatase activity
CRN74_RS17515	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
CRN74_RS17530	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CRN74_RS17535	COG2104	thiamine diphosphate biosynthetic process
CRN74_RS17550	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CRN74_RS17555	COG0085	RNA polymerase activity
CRN74_RS17560	COG0222	ribosome binding
CRN74_RS17565	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CRN74_RS17575	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CRN74_RS17580	COG0250	Participates in transcription elongation, termination and antitermination
CRN74_RS17620	COG1072	(Pantothenic acid kinase))
CRN74_RS17625	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
CRN74_RS17625	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
CRN74_RS17660	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CRN74_RS17665	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CRN74_RS17670	COG0009	L-threonylcarbamoyladenylate synthase
CRN74_RS17675	COG0551	DNA topoisomerase type I activity
CRN74_RS17685	COG0758	DNA mediated transformation
CRN74_RS17690	COG0242	peptide deformylase activity
CRN74_RS17695	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CRN74_RS17700	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CRN74_RS17700	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CRN74_RS17710	COG1970	mechanosensitive ion channel activity
CRN74_RS17715	COG3036	rescue of stalled ribosome
CRN74_RS17720	COG0789	Transcriptional regulator
CRN74_RS17730	COG0203	ribosomal protein L17
CRN74_RS17740	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CRN74_RS17745	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CRN74_RS17750	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CRN74_RS17755	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CRN74_RS17760	COG0201	protein transport
CRN74_RS17765	COG0200	Binds to the 23S rRNA
CRN74_RS17770	COG1841	ribosomal large subunit assembly
CRN74_RS17775	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CRN74_RS17780	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CRN74_RS17785	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CRN74_RS17795	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CRN74_RS17810	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CRN74_RS17815	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CRN74_RS17820	COG0255	Belongs to the universal ribosomal protein uL29 family
CRN74_RS17825	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CRN74_RS17830	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CRN74_RS17835	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CRN74_RS17840	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CRN74_RS17850	COG0089	rRNA binding
CRN74_RS17855	COG0088	Forms part of the polypeptide exit tunnel
CRN74_RS17860	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CRN74_RS17865	COG0051	transcription antitermination factor activity, RNA binding
CRN74_RS17880	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CRN74_RS17895	COG0049	tRNA binding
CRN74_RS17900	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CRN74_RS17905	COG2168	tRNA wobble position uridine thiolation
CRN74_RS17915	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
CRN74_RS17920	COG2964	Protein conserved in bacteria
CRN74_RS17925	COG0545	Peptidyl-prolyl cis-trans isomerase
CRN74_RS17935	COG1047	Peptidyl-prolyl cis-trans
CRN74_RS17940	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
CRN74_RS17950	COG2249	NAD(P)H dehydrogenase (quinone) activity
CRN74_RS17955	COG0488	(ABC) transporter
CRN74_RS17965	COG2175	clavaminate synthase activity
CRN74_RS17970	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CRN74_RS17980	COG4521	taurine ABC transporter
CRN74_RS17995	COG0429	hydrolase of the alpha beta-hydrolase fold
CRN74_RS18000	COG3089	Belongs to the UPF0270 family
CRN74_RS18005	COG3954	Phosphoribulokinase
CRN74_RS18010	COG1765	OsmC-like protein
CRN74_RS18020	COG1289	transmembrane transporter activity
CRN74_RS18035	COG1388	LysM domain
CRN74_RS18035	COG1470	cell adhesion involved in biofilm formation
CRN74_RS18080	COG0433	COG0433 Predicted ATPase
CRN74_RS18085	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CRN74_RS18090	COG1486	melibiose metabolic process
CRN74_RS18100	COG4771	TonB-dependent receptor
CRN74_RS18110	COG0738	Major facilitator superfamily
CRN74_RS18115	COG0402	S-adenosylhomocysteine deaminase activity
CRN74_RS18125	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CRN74_RS18140	COG1648	precorrin-2 dehydrogenase activity
CRN74_RS18140	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CRN74_RS18145	COG0180	Tryptophanyl-tRNA synthetase
CRN74_RS18155	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CRN74_RS18175	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CRN74_RS18180	COG4796	Type ii and iii secretion system protein
CRN74_RS18205	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CRN74_RS18210	COG0494	nUDIX hydrolase
CRN74_RS18220	COG1011	Hydrolase
CRN74_RS18225	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CRN74_RS18235	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
CRN74_RS18255	COG3188	usher protein
CRN74_RS18260	COG3121	Chaperone
CRN74_RS18285	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CRN74_RS18290	COG2183	response to ionizing radiation
CRN74_RS18295	COG1918	ferrous iron import across plasma membrane
CRN74_RS18315	COG0596	Alpha beta hydrolase
CRN74_RS18325	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CRN74_RS18325	COG0316	Belongs to the HesB IscA family
CRN74_RS18330	COG1640	4-alpha-glucanotransferase
CRN74_RS18335	COG0058	SHG alpha-glucan phosphorylase activity
CRN74_RS18340	COG2909	trisaccharide binding
CRN74_RS18355	COG0705	Rhomboid family
CRN74_RS18360	COG1349	DNA-binding transcription factor activity
CRN74_RS18365	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CRN74_RS18370	COG0058	SHG alpha-glucan phosphorylase activity
CRN74_RS18375	COG0297	glycogen (starch) synthase activity
CRN74_RS18385	COG1523	belongs to the glycosyl hydrolase 13 family
CRN74_RS18390	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CRN74_RS18395	COG3275	phosphorelay sensor kinase activity
CRN74_RS18400	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CRN74_RS18405	COG2095	MarC family integral membrane protein
CRN74_RS18410	COG3265	gluconokinase activity
CRN74_RS18415	COG2610	gluconate transmembrane transporter activity
CRN74_RS18420	COG1609	Transcriptional regulator
CRN74_RS18425	COG1741	Belongs to the pirin family
CRN74_RS18430	COG1247	-acetyltransferase
CRN74_RS18435	COG1082	Xylose isomerase domain protein TIM barrel
CRN74_RS18440	COG0673	inositol 2-dehydrogenase activity
CRN74_RS18460	COG3718	enzyme involved in inositol metabolism
CRN74_RS18470	COG2814	Major facilitator Superfamily
CRN74_RS18480	COG2814	Major facilitator Superfamily
CRN74_RS18485	COG0583	DNA-binding transcription factor activity
CRN74_RS18500	COG2197	response regulator
CRN74_RS18505	COG2081	HI0933 family
CRN74_RS18510	COG0306	phosphate transporter
CRN74_RS18520	COG0589	response to stress
CRN74_RS18535	COG0742	ribosomal rna small subunit methyltransferase
CRN74_RS18550	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
CRN74_RS18555	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CRN74_RS18560	COG1295	ribonuclease BN
CRN74_RS18565	COG2134	cdp-diacylglycerol pyrophosphatase
CRN74_RS18570	COG2982	Protein involved in outer membrane biogenesis
CRN74_RS18575	COG2200	EAL domain
CRN74_RS18580	COG1942	4-Oxalocrotonate Tautomerase
CRN74_RS18590	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CRN74_RS18595	COG0612	Peptidase, M16
CRN74_RS18605	COG1301	dicarboxylic acid transport
CRN74_RS18610	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CRN74_RS18615	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CRN74_RS18620	COG1561	YicC-like family, N-terminal region
CRN74_RS18640	COG4529	Protein conserved in bacteria
CRN74_RS18720	COG0305	Participates in initiation and elongation during chromosome replication
CRN74_RS18775	COG0582	viral genome integration into host DNA
CRN74_RS18785	COG2207	Transcriptional regulator
CRN74_RS18785	COG1609	Transcriptional regulator
CRN74_RS18790	COG4214	carbohydrate transport
CRN74_RS18800	COG4213	ABC transporter substrate-binding protein
CRN74_RS18805	COG2115	Belongs to the xylose isomerase family
CRN74_RS18810	COG1070	Carbohydrate kinase
CRN74_RS18820	COG3121	Chaperone
CRN74_RS18825	COG3188	usher protein
CRN74_RS18835	COG1335	isochorismatase
CRN74_RS18845	COG3274	enterobacterial common antigen metabolic process
CRN74_RS18850	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CRN74_RS18850	COG2213	PTS system mannitol-specific
CRN74_RS18855	COG0246	Mannitol dehydrogenase
CRN74_RS18860	COG3722	fumarate hydratase activity
CRN74_RS18870	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CRN74_RS18885	COG2258	MOSC domain
CRN74_RS18890	COG0840	transmembrane signaling receptor activity
CRN74_RS18900	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CRN74_RS18905	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CRN74_RS18910	COG0243	molybdopterin cofactor binding
CRN74_RS18910	COG3383	formate dehydrogenase (NAD+) activity
CRN74_RS18915	COG3383	formate dehydrogenase (NAD+) activity
CRN74_RS18915	COG0243	molybdopterin cofactor binding
CRN74_RS18920	COG0437	4 iron, 4 sulfur cluster binding
CRN74_RS18925	COG2864	formate dehydrogenase
CRN74_RS18930	COG3058	Necessary for formate dehydrogenase activity
CRN74_RS18935	COG1921	L-seryl-tRNASec selenium transferase activity
CRN74_RS18940	COG3276	selenocysteine insertion sequence binding
CRN74_RS18955	COG0751	glycine-tRNA ligase activity
CRN74_RS18960	COG0752	glycyl-tRNA synthetase alpha subunit
CRN74_RS18970	COG2818	Glycosylase
CRN74_RS18985	COG2885	chlorophyll binding
CRN74_RS19005	COG0366	Alpha amylase catalytic
CRN74_RS19010	COG3977	Valine--pyruvate aminotransferase
CRN74_RS19015	COG0569	domain protein
CRN74_RS19015	COG2985	domain, Protein
CRN74_RS19030	COG5645	(Lipo)protein
CRN74_RS19035	COG0823	Involved in the tonB-independent uptake of proteins
CRN74_RS19050	COG2423	ornithine cyclodeaminase activity
CRN74_RS19060	COG0561	phosphatase activity
CRN74_RS19065	COG0187	DNA topoisomerase II activity
CRN74_RS19075	COG0592	DNA-directed DNA polymerase activity
CRN74_RS19080	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CRN74_RS19090	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CRN74_RS19095	COG0594	ribonuclease P activity
CRN74_RS19105	COG0706	membrane insertase activity
CRN74_RS19110	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CRN74_RS19115	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CRN74_RS19125	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CRN74_RS19130	COG2011	ABC-type metal ion transport system permease component
CRN74_RS19135	COG0840	transmembrane signaling receptor activity
CRN74_RS19140	COG0431	NADPH-dependent FMN reductase
CRN74_RS19145	COG4191	Histidine kinase
CRN74_RS19160	COG2252	PERMEase
CRN74_RS19165	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CRN74_RS19170	COG0765	amino acid transport
CRN74_RS19175	COG0765	amino acid transport
CRN74_RS19180	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CRN74_RS19185	COG0704	Plays a role in the regulation of phosphate uptake
CRN74_RS19195	COG0581	inorganic phosphate transmembrane transporter activity
CRN74_RS19200	COG0573	inorganic phosphate transmembrane transporter activity
CRN74_RS19205	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CRN74_RS19215	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CRN74_RS19220	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CRN74_RS19225	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CRN74_RS19230	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CRN74_RS19235	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CRN74_RS19240	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CRN74_RS19245	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CRN74_RS19255	COG0356	it plays a direct role in the translocation of protons across the membrane
CRN74_RS19260	COG3312	ion transport
CRN74_RS19265	COG0357	Ribosomal RNA small subunit methyltransferase G
CRN74_RS19270	COG0445	tRNA wobble uridine modification
CRN74_RS19275	COG0716	FMN binding
CRN74_RS19280	COG1522	sequence-specific DNA binding
CRN74_RS19285	COG2502	aspartate--ammonia ligase
CRN74_RS19295	COG2425	protein containing a von Willebrand factor type A (vWA) domain
CRN74_RS19300	COG0714	Associated with various cellular activities
CRN74_RS19305	COG3158	transport of potassium into the cell
CRN74_RS19310	COG1869	D-ribose catabolic process
CRN74_RS19320	COG1172	Belongs to the binding-protein-dependent transport system permease family
CRN74_RS19325	COG1879	ABC-type sugar transport system periplasmic component
CRN74_RS19330	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CRN74_RS19335	COG1609	Transcriptional regulator
CRN74_RS19340	COG0477	Major facilitator Superfamily
CRN74_RS19345	COG2186	Transcriptional regulator
CRN74_RS19375	COG1763	Mo-molybdopterin cofactor biosynthetic process
CRN74_RS19385	COG3084	Protein conserved in bacteria
CRN74_RS19390	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CRN74_RS19395	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CRN74_RS19400	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CRN74_RS19400	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CRN74_RS19405	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CRN74_RS19410	COG3078	GTPase activator activity
CRN74_RS19420	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CRN74_RS19430	COG3852	Histidine kinase
CRN74_RS19445	COG1011	Hydrolase
CRN74_RS19450	COG1295	ribonuclease BN
CRN74_RS19460	COG0456	acetyltransferase
CRN74_RS19480	COG2982	Protein involved in outer membrane biogenesis
CRN74_RS19485	COG2233	PERMEase
CRN74_RS19490	COG0786	glutamate:sodium symporter activity
CRN74_RS19495	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CRN74_RS19500	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CRN74_RS19505	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CRN74_RS19510	COG1758	RNA polymerase activity
CRN74_RS19520	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CRN74_RS19525	COG2860	membrane
CRN74_RS19535	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CRN74_RS19540	COG1024	Enoyl-CoA hydratase
CRN74_RS19545	COG5001	Diguanylate cyclase
CRN74_RS19550	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
CRN74_RS19555	COG2986	histidine ammonia-lyase
CRN74_RS19570	COG1764	response to oxidative stress
CRN74_RS19575	COG2194	sulfuric ester hydrolase activity
CRN74_RS19580	COG2197	response regulator
CRN74_RS19585	COG3851	Histidine kinase
CRN74_RS19590	COG2271	Major facilitator Superfamily
CRN74_RS19600	COG2831	hemolysin activation secretion protein
CRN74_RS19610	COG0747	negative chemotaxis
CRN74_RS19615	COG0601	transmembrane transport
CRN74_RS19620	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CRN74_RS19625	COG0444	Belongs to the ABC transporter superfamily
CRN74_RS19630	COG4608	Belongs to the ABC transporter superfamily
CRN74_RS19635	COG2200	EAL domain
CRN74_RS19635	COG2199	diguanylate cyclase activity
CRN74_RS19640	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CRN74_RS19650	COG1309	transcriptional regulator
CRN74_RS19655	COG0756	dUTP diphosphatase activity
CRN74_RS19660	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CRN74_RS19670	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CRN74_RS19675	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CRN74_RS19680	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CRN74_RS19695	COG1519	Transferase
CRN74_RS19700	COG0859	PFAM glycosyl transferase family 9
CRN74_RS19705	COG0859	PFAM glycosyl transferase family 9
CRN74_RS19710	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CRN74_RS19715	COG0156	8-amino-7-oxononanoate synthase activity
CRN74_RS19725	COG2861	carbohydrate metabolic process
CRN74_RS19730	COG4942	peptidase
CRN74_RS19735	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CRN74_RS19740	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CRN74_RS19745	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CRN74_RS19750	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
CRN74_RS19755	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CRN74_RS19760	COG1045	serine acetyltransferase
CRN74_RS19765	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CRN74_RS19770	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CRN74_RS19770	COG2169	Transcriptional regulator
CRN74_RS19775	COG2205	protein histidine kinase activity
CRN74_RS19780	COG0745	RESPONSE REGULATOR receiver
CRN74_RS19785	COG3678	ATP-independent chaperone mediated protein folding
CRN74_RS19790	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CRN74_RS19800	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
CRN74_RS19820	COG3152	Membrane
CRN74_RS19830	COG0460	homoserine dehydrogenase
CRN74_RS19830	COG0527	aspartate kinase activity
CRN74_RS19835	COG0626	cystathionine gamma-synthase activity
CRN74_RS19840	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
CRN74_RS19845	COG0254	rRNA binding
CRN74_RS19855	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CRN74_RS19860	COG1609	Transcriptional regulator
CRN74_RS19865	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CRN74_RS19870	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CRN74_RS19875	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CRN74_RS19880	COG1575	Belongs to the MenA family. Type 1 subfamily
CRN74_RS19885	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CRN74_RS19890	COG3074	FtsZ-dependent cytokinesis
CRN74_RS19900	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CRN74_RS19905	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CRN74_RS19910	COG1494	fructose-1,6-bisphosphatase
CRN74_RS19915	COG2814	Major facilitator Superfamily
CRN74_RS19925	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CRN74_RS19940	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CRN74_RS19945	COG0165	Argininosuccinate lyase
CRN74_RS19950	COG1629	transport
CRN74_RS19975	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CRN74_RS19980	COG0678	peroxiredoxin activity
CRN74_RS19980	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CRN74_RS19990	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CRN74_RS20005	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CRN74_RS20015	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CRN74_RS20060	COG1879	ABC-type sugar transport system periplasmic component
CRN74_RS20065	COG1129	ABC transporter
CRN74_RS20070	COG1172	Belongs to the binding-protein-dependent transport system permease family
CRN74_RS20075	COG1172	Belongs to the binding-protein-dependent transport system permease family
CRN74_RS20080	COG0583	DNA-binding transcription factor activity
CRN74_RS20085	COG3085	chromosome segregation
CRN74_RS20105	COG3978	acetolactate synthase activity
CRN74_RS20110	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CRN74_RS20115	COG0129	dihydroxy-acid dehydratase activity
CRN74_RS20120	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CRN74_RS20130	COG0583	DNA-binding transcription factor activity
CRN74_RS20135	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CRN74_RS20140	COG3121	Chaperone
CRN74_RS20155	COG3121	Chaperone
CRN74_RS20165	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CRN74_RS20180	COG0248	Ppx GppA phosphatase
CRN74_RS20190	COG3118	belongs to the thioredoxin family
CRN74_RS20195	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CRN74_RS20200	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CRN74_RS20205	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
CRN74_RS20210	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CRN74_RS20215	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CRN74_RS20220	COG1088	dTDP-glucose 4,6-dehydratase activity
CRN74_RS20225	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CRN74_RS20230	COG0456	acetyltransferase
CRN74_RS20235	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CRN74_RS20240	COG2244	polysaccharide biosynthetic process
CRN74_RS20245	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CRN74_RS20260	COG1113	amino acid transport
CRN74_RS20285	COG3071	HemY protein
CRN74_RS20290	COG2959	enzyme of heme biosynthesis
CRN74_RS20295	COG1587	Uroporphyrinogen-III synthase
CRN74_RS20300	COG0181	hydroxymethylbilane synthase activity
CRN74_RS20305	COG3072	Adenylate cyclase
CRN74_RS20315	COG5567	small periplasmic lipoprotein
CRN74_RS20320	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CRN74_RS20325	COG3159	Protein conserved in bacteria
CRN74_RS20330	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
CRN74_RS20335	COG1011	Hydrolase
CRN74_RS20340	COG0210	DNA helicase
CRN74_RS20355	COG5441	Belongs to the UPF0261 family
CRN74_RS20360	COG5564	TIM-barrel signal transduction protein
CRN74_RS20380	COG2050	protein possibly involved in aromatic compounds catabolism
CRN74_RS20385	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
CRN74_RS20390	COG0514	ATP-dependent DNA helicase (RecQ)
CRN74_RS20395	COG1280	lysine exporter protein (LysE YggA)
CRN74_RS20400	COG1280	lysine exporter protein (LysE YggA)
CRN74_RS20405	COG2267	carboxylic ester hydrolase activity
CRN74_RS20410	COG0561	phosphatase activity
CRN74_RS20415	COG0584	glycerophosphoryl diester phosphodiesterase
CRN74_RS20420	COG2271	Major facilitator Superfamily
CRN74_RS20425	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CRN74_RS20435	COG0247	lactate metabolic process
CRN74_RS20445	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
CRN74_RS20450	COG0425	Belongs to the sulfur carrier protein TusA family
CRN74_RS20460	COG3714	YhhN family
CRN74_RS20475	COG3776	membrane
CRN74_RS20480	COG0742	ribosomal rna small subunit methyltransferase
CRN74_RS20485	COG0552	protein localization to endoplasmic reticulum
CRN74_RS20485	COG0552	protein localization to endoplasmic reticulum
CRN74_RS20490	COG2884	Cell division ATP-binding protein ftsE
CRN74_RS20495	COG2177	Part of the ABC transporter FtsEX involved in
CRN74_RS20505	COG0456	acetyltransferase
CRN74_RS20510	COG0683	leucine binding
CRN74_RS20520	COG4177	L-phenylalanine transmembrane transporter activity
CRN74_RS20530	COG0410	ABC transporter
CRN74_RS20565	COG1653	transport
CRN74_RS20570	COG1175	transmembrane transport
CRN74_RS20575	COG0395	ABC-type sugar transport system, permease component
CRN74_RS20580	COG3842	ATPase activity
CRN74_RS20585	COG0584	glycerophosphoryl diester phosphodiesterase
CRN74_RS20590	COG0679	Auxin Efflux Carrier
CRN74_RS20595	COG0697	spore germination
CRN74_RS20600	COG0583	DNA-binding transcription factor activity
CRN74_RS20605	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CRN74_RS20610	COG0412	Dienelactone hydrolase
CRN74_RS20625	COG1966	Carbon starvation protein
CRN74_RS20630	COG0586	Pfam SNARE associated Golgi protein
CRN74_RS20635	COG1322	Protein conserved in bacteria
CRN74_RS20640	COG2226	methyltransferase
CRN74_RS20650	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CRN74_RS20655	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CRN74_RS20665	COG0805	protein transport
CRN74_RS20685	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CRN74_RS20695	COG0183	Belongs to the thiolase family
CRN74_RS20700	COG1250	3-hydroxyacyl-CoA dehydrogenase
CRN74_RS20700	COG1024	Enoyl-CoA hydratase
CRN74_RS20710	COG1739	Uncharacterized protein family UPF0029
CRN74_RS20715	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CRN74_RS20770	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CRN74_RS20775	COG3162	membrane
CRN74_RS20780	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CRN74_RS20785	COG1301	dicarboxylic acid transport
CRN74_RS20955	COG0425	Belongs to the sulfur carrier protein TusA family
CRN74_RS20960	COG3093	addiction module antidote protein HigA
CRN74_RS20975	COG1595	DNA-templated transcription, initiation
CRN74_RS20980	COG3712	iron ion homeostasis
CRN74_RS20985	COG4771	TonB-dependent receptor
CRN74_RS20990	COG4178	(ABC) transporter
CRN74_RS20995	COG0612	Peptidase, M16
CRN74_RS21005	COG3397	chitin binding
CRN74_RS21015	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CRN74_RS21060	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CRN74_RS21100	COG2205	protein histidine kinase activity
CRN74_RS21105	COG2197	response regulator
CRN74_RS21255	COG1196	nuclear chromosome segregation
CRN74_RS21255	COG3264	Mechanosensitive ion channel
CRN74_RS21260	COG4774	siderophore transport
CRN74_RS21270	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CRN74_RS21275	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CRN74_RS21280	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CRN74_RS21285	COG4558	Periplasmic binding protein
CRN74_RS21290	COG3720	iron ion transport
CRN74_RS21295	COG4771	TonB-dependent receptor
CRN74_RS21305	COG0702	epimerase
CRN74_RS21310	COG3721	Heme iron utilization protein
CRN74_RS21320	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
CRN74_RS21330	COG0457	Tetratricopeptide repeat
CRN74_RS21335	COG1215	transferase activity, transferring glycosyl groups
CRN74_RS21345	COG0489	protein tyrosine kinase activity
CRN74_RS21360	COG0463	Glycosyl transferase, family 2
CRN74_RS21390	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CRN74_RS21395	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CRN74_RS21395	COG0543	2 iron, 2 sulfur cluster binding
CRN74_RS21410	COG1309	transcriptional regulator
CRN74_RS21420	COG2084	Dehydrogenase
CRN74_RS21425	COG1929	Belongs to the glycerate kinase type-1 family
CRN74_RS21430	COG3835	regulator
CRN74_RS21435	COG2721	sulfolactate sulfo-lyase activity
CRN74_RS21440	COG1929	Belongs to the glycerate kinase type-1 family
CRN74_RS21445	COG2271	Major facilitator Superfamily
CRN74_RS21450	COG0493	'glutamate synthase
CRN74_RS21450	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CRN74_RS21455	COG0493	'glutamate synthase
CRN74_RS21455	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CRN74_RS21460	COG3383	formate dehydrogenase (NAD+) activity
CRN74_RS21465	COG4232	protein-disulfide reductase activity
CRN74_RS21475	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CRN74_RS21490	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CRN74_RS21495	COG0459	protein refolding
CRN74_RS21510	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CRN74_RS21530	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
CRN74_RS21535	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
CRN74_RS21540	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CRN74_RS21545	COG1053	succinate dehydrogenase
CRN74_RS21555	COG3264	Mechanosensitive ion channel
CRN74_RS21555	COG1511	domain protein
CRN74_RS21560	COG0688	phosphatidylethanolamine metabolic process
CRN74_RS21565	COG1162	GTPase activity
CRN74_RS21570	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
CRN74_RS21595	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CRN74_RS21600	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CRN74_RS21600	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CRN74_RS21605	COG0802	atpase or kinase
CRN74_RS21620	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CRN74_RS21630	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CRN74_RS21635	COG0330	HflC and HflK could
CRN74_RS21640	COG0330	HflC and HflK could
CRN74_RS21645	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
CRN74_RS21655	COG1959	2 iron, 2 sulfur cluster binding
CRN74_RS21660	COG0557	exoribonuclease II activity
CRN74_RS21665	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CRN74_RS21670	COG1960	acyl-CoA dehydrogenase activity
CRN74_RS21675	COG3650	response to hydrogen peroxide
CRN74_RS21680	COG1073	alpha beta
CRN74_RS21695	COG0360	Binds together with S18 to 16S ribosomal RNA
CRN74_RS21705	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CRN74_RS21710	COG0359	binds to the 23S rRNA
CRN74_RS21720	COG3061	Opacity-associated protein A
CRN74_RS21725	COG0545	Peptidyl-prolyl cis-trans isomerase
CRN74_RS21735	COG0737	Belongs to the 5'-nucleotidase family
CRN74_RS21740	COG1218	3'(2'),5'-bisphosphate nucleotidase
CRN74_RS21745	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
CRN74_RS21755	COG1253	flavin adenine dinucleotide binding
CRN74_RS21760	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CRN74_RS21770	COG2911	Protein conserved in bacteria
CRN74_RS21775	COG2105	PFAM AIG2 family protein
CRN74_RS21780	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CRN74_RS21795	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CRN74_RS21815	COG3423	Transcriptional regulator
CRN74_RS21825	COG0142	geranyltranstransferase activity
CRN74_RS21835	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CRN74_RS21840	COG0697	spore germination
CRN74_RS21845	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CRN74_RS21850	COG0642	Histidine kinase
CRN74_RS21855	COG0745	RESPONSE REGULATOR receiver
CRN74_RS21860	COG2027	D-alanyl-D-alanine carboxypeptidase
CRN74_RS21870	COG1534	Rna-binding protein
CRN74_RS21875	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
CRN74_RS21885	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CRN74_RS21895	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CRN74_RS21915	COG0195	Participates in both transcription termination and antitermination
CRN74_RS21925	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CRN74_RS21930	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CRN74_RS21940	COG1185	polyribonucleotide nucleotidyltransferase activity
CRN74_RS21955	COG0513	Belongs to the DEAD box helicase family
CRN74_RS21960	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CRN74_RS21965	COG0814	amino acid
CRN74_RS21970	COG3681	Belongs to the UPF0597 family
CRN74_RS21975	COG0826	peptidase U32
CRN74_RS21980	COG0826	peptidase U32
CRN74_RS21985	COG3154	lipid carrier protein
CRN74_RS21990	COG3153	acetyltransferase
CRN74_RS22000	COG0531	amino acid
CRN74_RS22005	COG1982	Orn Lys Arg decarboxylase major
CRN74_RS22020	COG1653	transport
CRN74_RS22025	COG1175	transmembrane transport
CRN74_RS22030	COG0395	ABC-type sugar transport system, permease component
CRN74_RS22035	COG3842	ATPase activity
CRN74_RS22050	COG0702	epimerase
CRN74_RS22055	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CRN74_RS22060	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
CRN74_RS22065	COG3454	Phosphonate metabolism
CRN74_RS22070	COG4778	phosphonate C-P lyase system protein PhnL
CRN74_RS22075	COG4107	phosphonate C-P lyase system protein PhnK
CRN74_RS22080	COG3627	carbon phosphorus lyase activity
CRN74_RS22085	COG3626	phosphonate metabolism
CRN74_RS22090	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
CRN74_RS22095	COG3624	Phosphonate C-P lyase system protein PhnG
CRN74_RS22100	COG2188	Transcriptional regulator
CRN74_RS22115	COG0602	queuosine metabolic process
CRN74_RS22135	COG4608	Belongs to the ABC transporter superfamily
CRN74_RS22140	COG0444	Belongs to the ABC transporter superfamily
CRN74_RS22145	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CRN74_RS22150	COG0601	transmembrane transport
CRN74_RS22160	COG2731	YhcH YjgK YiaL family protein
CRN74_RS22170	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
CRN74_RS22185	COG2927	DNA polymerase III (CHI subunit)
CRN74_RS22190	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CRN74_RS22195	COG0795	lipopolysaccharide-transporting ATPase activity
CRN74_RS22200	COG0795	lipopolysaccharide-transporting ATPase activity
CRN74_RS22210	COG0582	viral genome integration into host DNA
CRN74_RS22240	COG0514	ATP-dependent DNA helicase (RecQ)
CRN74_RS22275	COG0720	synthase
CRN74_RS22365	COG2771	luxR family
CRN74_RS22385	COG1396	sequence-specific DNA binding
CRN74_RS22390	COG3550	peptidyl-serine autophosphorylation
CRN74_RS22405	COG1830	Aldolase
CRN74_RS22415	COG1172	Belongs to the binding-protein-dependent transport system permease family
CRN74_RS22420	COG1172	Belongs to the binding-protein-dependent transport system permease family
CRN74_RS22425	COG1129	ABC transporter
CRN74_RS22430	COG2390	Transcriptional regulator
CRN74_RS22435	COG1070	Carbohydrate kinase
CRN74_RS22440	COG0859	PFAM glycosyl transferase family 9
CRN74_RS22455	COG2235	arginine
CRN74_RS22460	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CRN74_RS22465	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CRN74_RS22475	COG2376	Dihydroxyacetone kinase
CRN74_RS22480	COG1461	Dihydroxyacetone kinase
CRN74_RS22485	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
CRN74_RS22485	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CRN74_RS22485	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CRN74_RS22495	COG2192	nodulation
CRN74_RS22510	COG0738	Major facilitator superfamily
CRN74_RS22520	COG3284	Transcriptional regulator
CRN74_RS22555	COG0667	Aldo Keto reductase
CRN74_RS22560	COG2813	Specifically methylates the guanine in position
CRN74_RS22565	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
CRN74_RS22575	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CRN74_RS22580	COG2823	Periplasmic or secreted lipoprotein
CRN74_RS22590	COG4667	esterase of the alpha-beta hydrolase superfamily
CRN74_RS22595	COG0084	hydrolase, TatD family'
CRN74_RS22600	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CRN74_RS22615	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
CRN74_RS22630	COG2026	Addiction module toxin, RelE StbE family
CRN74_RS22635	COG3726	membrane protein affecting hemolysin expression
CRN74_RS22640	COG0560	Phosphoserine phosphatase
CRN74_RS22655	COG0604	alcohol dehydrogenase
CRN74_RS22670	COG1454	alcohol dehydrogenase
CRN74_RS22705	COG0488	(ABC) transporter
CRN74_RS22710	COG2885	chlorophyll binding
CRN74_RS22715	COG2199	diguanylate cyclase activity
CRN74_RS22725	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CRN74_RS22730	COG0741	lytic transglycosylase activity
CRN74_RS22735	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
CRN74_RS22740	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
CRN74_RS22745	COG0406	alpha-ribazole phosphatase activity
CRN74_RS22750	COG2207	Transcriptional regulator
CRN74_RS22750	COG3708	Transcriptional regulator
CRN74_RS22760	COG3045	CreA protein
CRN74_RS22765	COG0745	RESPONSE REGULATOR receiver
CRN74_RS22785	COG0083	homoserine kinase activity
CRN74_RS22795	COG3022	response to hydroperoxide
CRN74_RS22805	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CRN74_RS22810	COG0521	Mo-molybdopterin cofactor biosynthetic process
CRN74_RS22825	COG1584	GPR1 FUN34 yaaH family protein
CRN74_RS22835	COG0484	heat shock protein binding
CRN74_RS22845	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CRN74_RS22850	COG0583	DNA-binding transcription factor activity
CRN74_RS22865	COG0196	riboflavin kinase activity
CRN74_RS22870	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CRN74_RS22880	COG1047	Peptidyl-prolyl cis-trans
CRN74_RS22885	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CRN74_RS22900	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CRN74_RS22905	COG1280	lysine exporter protein (LysE YggA)
CRN74_RS22910	COG2966	Psort location CytoplasmicMembrane, score
CRN74_RS22920	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CRN74_RS22925	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CRN74_RS22930	COG2967	ApaG domain
CRN74_RS22935	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CRN74_RS22950	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CRN74_RS22955	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CRN74_RS22965	COG0564	pseudouridine synthase activity
CRN74_RS23000	COG2375	cellular response to nickel ion
CRN74_RS23010	COG0417	DNA replication proofreading
CRN74_RS23015	COG0586	Pfam SNARE associated Golgi protein
CRN74_RS23020	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
CRN74_RS23025	COG1178	ABC-type Fe3 transport system permease component
CRN74_RS23030	COG4143	(ABC) transporter
CRN74_RS23035	COG4533	DNA binding
CRN74_RS23040	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CRN74_RS23045	COG1882	Formate acetyltransferase
CRN74_RS23050	COG2814	Major facilitator Superfamily
CRN74_RS23055	COG0814	amino acid
CRN74_RS23060	COG3033	Beta-eliminating lyase
CRN74_RS23075	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CRN74_RS23080	COG0473	3-isopropylmalate dehydrogenase activity
CRN74_RS23095	COG1022	Amp-dependent synthetase and ligase
CRN74_RS23100	COG0028	Belongs to the TPP enzyme family
CRN74_RS23125	COG0275	rRNA processing
CRN74_RS23130	COG3116	cell division
CRN74_RS23135	COG0768	penicillin binding
CRN74_RS23140	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CRN74_RS23145	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity