locus-tag	class	description
CRN75_RS00010	COG0187	DNA topoisomerase II activity
CRN75_RS00015	COG0561	phosphatase activity
CRN75_RS00020	COG2423	ornithine cyclodeaminase activity
CRN75_RS00040	COG3727	T/G mismatch-specific endonuclease activity
CRN75_RS00050	COG0823	Involved in the tonB-independent uptake of proteins
CRN75_RS00055	COG5645	(Lipo)protein
CRN75_RS00075	COG3977	Valine--pyruvate aminotransferase
CRN75_RS00080	COG0366	Alpha amylase catalytic
CRN75_RS00120	COG2818	Glycosylase
CRN75_RS00130	COG0751	glycine-tRNA ligase activity
CRN75_RS00140	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CRN75_RS00140	COG2213	PTS system mannitol-specific
CRN75_RS00145	COG0246	Mannitol dehydrogenase
CRN75_RS00150	COG3722	fumarate hydratase activity
CRN75_RS00160	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CRN75_RS00180	COG2258	MOSC domain
CRN75_RS00185	COG0840	transmembrane signaling receptor activity
CRN75_RS00190	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CRN75_RS00195	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CRN75_RS00200	COG3383	formate dehydrogenase (NAD+) activity
CRN75_RS00200	COG0243	molybdopterin cofactor binding
CRN75_RS00205	COG0243	molybdopterin cofactor binding
CRN75_RS00205	COG3383	formate dehydrogenase (NAD+) activity
CRN75_RS00210	COG0437	4 iron, 4 sulfur cluster binding
CRN75_RS00215	COG2864	formate dehydrogenase
CRN75_RS00220	COG3058	Necessary for formate dehydrogenase activity
CRN75_RS00225	COG1921	L-seryl-tRNASec selenium transferase activity
CRN75_RS00230	COG3276	selenocysteine insertion sequence binding
CRN75_RS00240	COG3274	enterobacterial common antigen metabolic process
CRN75_RS00255	COG1070	Carbohydrate kinase
CRN75_RS00260	COG2115	Belongs to the xylose isomerase family
CRN75_RS00265	COG4213	ABC transporter substrate-binding protein
CRN75_RS00275	COG4214	carbohydrate transport
CRN75_RS00280	COG1609	Transcriptional regulator
CRN75_RS00280	COG2207	Transcriptional regulator
CRN75_RS00285	COG0582	viral genome integration into host DNA
CRN75_RS00340	COG0305	Participates in initiation and elongation during chromosome replication
CRN75_RS00355	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
CRN75_RS00360	COG2986	histidine ammonia-lyase
CRN75_RS00385	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
CRN75_RS00400	COG0463	Glycosyl transferase, family 2
CRN75_RS00420	COG1846	Transcriptional regulator
CRN75_RS00425	COG1764	response to oxidative stress
CRN75_RS00430	COG2194	sulfuric ester hydrolase activity
CRN75_RS00435	COG2197	response regulator
CRN75_RS00440	COG3851	Histidine kinase
CRN75_RS00445	COG2271	Major facilitator Superfamily
CRN75_RS00460	COG2831	hemolysin activation secretion protein
CRN75_RS00465	COG3210	domain, Protein
CRN75_RS00475	COG0747	negative chemotaxis
CRN75_RS00480	COG0601	transmembrane transport
CRN75_RS00485	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CRN75_RS00490	COG0444	Belongs to the ABC transporter superfamily
CRN75_RS00495	COG4608	Belongs to the ABC transporter superfamily
CRN75_RS00500	COG2194	sulfuric ester hydrolase activity
CRN75_RS00530	COG1215	transferase activity, transferring glycosyl groups
CRN75_RS00535	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
CRN75_RS00540	COG0457	Tetratricopeptide repeat
CRN75_RS00540	COG3118	belongs to the thioredoxin family
CRN75_RS00545	COG2200	EAL domain
CRN75_RS00545	COG2199	diguanylate cyclase activity
CRN75_RS00550	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CRN75_RS00565	COG1301	dicarboxylic acid transport
CRN75_RS00570	COG0612	Peptidase, M16
CRN75_RS00575	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CRN75_RS00580	COG1942	4-Oxalocrotonate Tautomerase
CRN75_RS00585	COG2200	EAL domain
CRN75_RS00590	COG2982	Protein involved in outer membrane biogenesis
CRN75_RS00595	COG2134	cdp-diacylglycerol pyrophosphatase
CRN75_RS00600	COG1295	ribonuclease BN
CRN75_RS00610	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CRN75_RS00615	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
CRN75_RS00630	COG0742	ribosomal rna small subunit methyltransferase
CRN75_RS00645	COG0589	response to stress
CRN75_RS00655	COG0306	phosphate transporter
CRN75_RS00660	COG2081	HI0933 family
CRN75_RS00680	COG0583	DNA-binding transcription factor activity
CRN75_RS00685	COG2814	Major facilitator Superfamily
CRN75_RS00695	COG2814	Major facilitator Superfamily
CRN75_RS00705	COG3718	enzyme involved in inositol metabolism
CRN75_RS00715	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CRN75_RS00725	COG0673	inositol 2-dehydrogenase activity
CRN75_RS00730	COG1082	Xylose isomerase domain protein TIM barrel
CRN75_RS00735	COG1082	Xylose isomerase domain protein TIM barrel
CRN75_RS00740	COG1247	-acetyltransferase
CRN75_RS00745	COG1741	Belongs to the pirin family
CRN75_RS00750	COG1609	Transcriptional regulator
CRN75_RS00755	COG2610	gluconate transmembrane transporter activity
CRN75_RS00760	COG3265	gluconokinase activity
CRN75_RS00765	COG2095	MarC family integral membrane protein
CRN75_RS00770	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CRN75_RS00780	COG0463	Glycosyl transferase, family 2
CRN75_RS00820	COG3275	phosphorelay sensor kinase activity
CRN75_RS00825	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CRN75_RS00830	COG1523	belongs to the glycosyl hydrolase 13 family
CRN75_RS00840	COG0297	glycogen (starch) synthase activity
CRN75_RS00845	COG0058	SHG alpha-glucan phosphorylase activity
CRN75_RS00850	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CRN75_RS00865	COG1349	DNA-binding transcription factor activity
CRN75_RS00870	COG0705	Rhomboid family
CRN75_RS00885	COG2909	trisaccharide binding
CRN75_RS00890	COG0058	SHG alpha-glucan phosphorylase activity
CRN75_RS00895	COG1640	4-alpha-glucanotransferase
CRN75_RS00900	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CRN75_RS00900	COG0316	Belongs to the HesB IscA family
CRN75_RS00905	COG1040	competence protein
CRN75_RS00910	COG0596	Alpha beta hydrolase
CRN75_RS00920	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CRN75_RS00925	COG1918	ferrous iron import across plasma membrane
CRN75_RS00930	COG2183	response to ionizing radiation
CRN75_RS00935	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CRN75_RS00960	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CRN75_RS00965	COG1011	Hydrolase
CRN75_RS00975	COG0494	nUDIX hydrolase
CRN75_RS00980	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CRN75_RS01005	COG4796	Type ii and iii secretion system protein
CRN75_RS01010	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CRN75_RS01030	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CRN75_RS01040	COG0180	Tryptophanyl-tRNA synthetase
CRN75_RS01045	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CRN75_RS01045	COG1648	precorrin-2 dehydrogenase activity
CRN75_RS01060	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CRN75_RS01065	COG0402	S-adenosylhomocysteine deaminase activity
CRN75_RS01070	COG0738	Major facilitator superfamily
CRN75_RS01090	COG1486	melibiose metabolic process
CRN75_RS01100	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CRN75_RS01110	COG0433	COG0433 Predicted ATPase
CRN75_RS01125	COG1289	transmembrane transporter activity
CRN75_RS01135	COG1765	OsmC-like protein
CRN75_RS01140	COG3954	Phosphoribulokinase
CRN75_RS01145	COG3089	Belongs to the UPF0270 family
CRN75_RS01150	COG0429	hydrolase of the alpha beta-hydrolase fold
CRN75_RS01165	COG4521	taurine ABC transporter
CRN75_RS01175	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CRN75_RS01180	COG2175	clavaminate synthase activity
CRN75_RS01190	COG0488	(ABC) transporter
CRN75_RS01195	COG2249	NAD(P)H dehydrogenase (quinone) activity
CRN75_RS01205	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
CRN75_RS01210	COG1047	Peptidyl-prolyl cis-trans
CRN75_RS01220	COG0545	Peptidyl-prolyl cis-trans isomerase
CRN75_RS01225	COG2964	Protein conserved in bacteria
CRN75_RS01240	COG2168	tRNA wobble position uridine thiolation
CRN75_RS01245	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CRN75_RS01250	COG0049	tRNA binding
CRN75_RS01265	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CRN75_RS01280	COG0051	transcription antitermination factor activity, RNA binding
CRN75_RS01285	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CRN75_RS01295	COG0089	rRNA binding
CRN75_RS01300	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CRN75_RS01305	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CRN75_RS01310	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CRN75_RS01315	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CRN75_RS01320	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CRN75_RS01325	COG0255	Belongs to the universal ribosomal protein uL29 family
CRN75_RS01330	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CRN75_RS01335	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CRN75_RS01345	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CRN75_RS01350	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CRN75_RS01360	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CRN75_RS01375	COG1841	ribosomal large subunit assembly
CRN75_RS01380	COG0200	Binds to the 23S rRNA
CRN75_RS01385	COG0201	protein transport
CRN75_RS01390	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CRN75_RS01395	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CRN75_RS01400	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CRN75_RS01405	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CRN75_RS01410	COG0202	RNA polymerase activity
CRN75_RS01415	COG0203	ribosomal protein L17
CRN75_RS01425	COG0789	Transcriptional regulator
CRN75_RS01430	COG3036	rescue of stalled ribosome
CRN75_RS01435	COG1970	mechanosensitive ion channel activity
CRN75_RS01445	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CRN75_RS01445	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CRN75_RS01450	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CRN75_RS01455	COG0242	peptide deformylase activity
CRN75_RS01460	COG0758	DNA mediated transformation
CRN75_RS01470	COG0551	DNA topoisomerase type I activity
CRN75_RS01475	COG0009	L-threonylcarbamoyladenylate synthase
CRN75_RS01480	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CRN75_RS01485	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CRN75_RS01525	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
CRN75_RS01530	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CRN75_RS01535	COG2224	Isocitrate lyase
CRN75_RS01540	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
CRN75_RS01545	COG0183	Belongs to the thiolase family
CRN75_RS01550	COG2031	fatty acid transporter
CRN75_RS01555	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CRN75_RS01560	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CRN75_RS01565	COG2204	response regulator
CRN75_RS01570	COG3852	Histidine kinase
CRN75_RS01575	COG1414	Transcriptional regulator
CRN75_RS01600	COG0527	aspartate kinase activity
CRN75_RS01615	COG3833	ABC-type maltose transport systems, permease component
CRN75_RS01620	COG1175	transmembrane transport
CRN75_RS01625	COG2182	Extracellular solute-binding protein
CRN75_RS01640	COG4580	involved in the transport of maltose and maltodextrins
CRN75_RS01655	COG3161	chorismate lyase activity
CRN75_RS01665	COG2937	Belongs to the GPAT DAPAT family
CRN75_RS01670	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CRN75_RS01675	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CRN75_RS01680	COG3237	CsbD-like
CRN75_RS01685	COG0735	belongs to the Fur family
CRN75_RS01690	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CRN75_RS01715	COG1448	Aminotransferase
CRN75_RS01720	COG2315	Protein conserved in bacteria
CRN75_RS01725	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CRN75_RS01740	COG2252	PERMEase
CRN75_RS01750	COG0025	NhaP-type Na H and K H
CRN75_RS01755	COG0583	DNA-binding transcription factor activity
CRN75_RS01760	COG1380	Effector of murein hydrolase LrgA
CRN75_RS01780	COG1126	abc transporter atp-binding protein
CRN75_RS01785	COG0765	amino acid transport
CRN75_RS01790	COG4597	amino acid ABC transporter
CRN75_RS01795	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CRN75_RS01805	COG1560	Kdo2-lipid A biosynthetic process
CRN75_RS01810	COG0471	metal ion transport
CRN75_RS01815	COG1278	Cold shock
CRN75_RS01820	COG1278	Cold shock
CRN75_RS01825	COG1278	Cold shock
CRN75_RS01830	COG3133	Outer membrane lipoprotein
CRN75_RS01835	COG3706	GGDEF domain
CRN75_RS01840	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
CRN75_RS01845	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CRN75_RS01850	COG2264	protein methyltransferase activity
CRN75_RS01855	COG4145	pantothenate transmembrane transporter activity
CRN75_RS01860	COG3924	membrane
CRN75_RS01865	COG0439	Biotin carboxylase
CRN75_RS01870	COG0511	ligase activity, forming carbon-carbon bonds
CRN75_RS01875	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CRN75_RS01880	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
CRN75_RS01890	COG0604	alcohol dehydrogenase
CRN75_RS01895	COG2199	diguanylate cyclase activity
CRN75_RS01895	COG2200	EAL domain
CRN75_RS01900	COG1077	Cell shape determining protein MreB Mrl
CRN75_RS01905	COG1792	Involved in formation and maintenance of cell shape
CRN75_RS01910	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
CRN75_RS01915	COG0424	maF-like protein
CRN75_RS01920	COG1530	ribonuclease E activity
CRN75_RS01925	COG3164	Protein of unknown function
CRN75_RS01930	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CRN75_RS01935	COG0312	modulator of DNA gyrase
CRN75_RS01940	COG0583	DNA-binding transcription factor activity
CRN75_RS01950	COG1566	PFAM secretion protein HlyD family protein
CRN75_RS01955	COG1289	transmembrane transporter activity
CRN75_RS01970	COG2732	(Barnase) inhibitor
CRN75_RS01975	COG3028	Belongs to the UPF0307 family
CRN75_RS01980	COG0312	modulator of DNA gyrase
CRN75_RS01990	COG3783	Cytochrome b(562)
CRN75_RS01995	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CRN75_RS02025	COG3964	amidohydrolase
CRN75_RS02040	COG2706	6-phosphogluconolactonase activity
CRN75_RS02045	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CRN75_RS02045	COG3711	transcriptional antiterminator
CRN75_RS02050	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CRN75_RS02060	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CRN75_RS02060	COG1263	PTS System
CRN75_RS02065	COG0366	Alpha amylase catalytic
CRN75_RS02085	COG2308	Evidence 4 Homologs of previously reported genes of
CRN75_RS02095	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
CRN75_RS02100	COG0540	Belongs to the ATCase OTCase family
CRN75_RS02105	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CRN75_RS02110	COG1660	Displays ATPase and GTPase activities
CRN75_RS02125	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CRN75_RS02130	COG1137	ATPase activity
CRN75_RS02135	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
CRN75_RS02140	COG3117	lipopolysaccharide transmembrane transporter activity
CRN75_RS02145	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
CRN75_RS02150	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CRN75_RS02150	COG0517	IMP dehydrogenase activity
CRN75_RS02155	COG0530	calcium, potassium:sodium antiporter activity
CRN75_RS02160	COG1127	ABC transporter
CRN75_RS02165	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CRN75_RS02170	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CRN75_RS02175	COG2854	intermembrane phospholipid transfer
CRN75_RS02180	COG3113	response to antibiotic
CRN75_RS02185	COG5007	Belongs to the BolA IbaG family
CRN75_RS02190	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CRN75_RS02195	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CRN75_RS02200	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CRN75_RS02205	COG3105	Protein conserved in bacteria
CRN75_RS02210	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
CRN75_RS02215	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CRN75_RS02220	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CRN75_RS02225	COG0625	glutathione transferase activity
CRN75_RS02230	COG2969	positive regulation of protein catabolic process
CRN75_RS02240	COG0493	'glutamate synthase
CRN75_RS02245	COG0067	glutamate synthase
CRN75_RS02245	COG0069	glutamate synthase activity
CRN75_RS02245	COG0070	glutamate synthase
CRN75_RS02250	COG1242	4 iron, 4 sulfur cluster binding
CRN75_RS02255	COG5002	protein histidine kinase activity
CRN75_RS02255	COG2198	Histidine kinase
CRN75_RS02255	COG0784	Response regulator, receiver
CRN75_RS02265	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
CRN75_RS02270	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CRN75_RS02275	COG2823	Periplasmic or secreted lipoprotein
CRN75_RS02280	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
CRN75_RS02285	COG0792	nuclease activity
CRN75_RS02295	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CRN75_RS02325	COG0667	Aldo Keto reductase
CRN75_RS02345	COG1064	alcohol dehydrogenase
CRN75_RS02350	COG1741	Belongs to the pirin family
CRN75_RS02355	COG0583	DNA-binding transcription factor activity
CRN75_RS02360	COG0435	Glutathione S-transferase
CRN75_RS02365	COG2259	Doxx family
CRN75_RS02375	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
CRN75_RS02380	COG4575	ribosome binding
CRN75_RS02395	COG0586	Pfam SNARE associated Golgi protein
CRN75_RS02410	COG2271	Major facilitator Superfamily
CRN75_RS02415	COG1904	glucuronate isomerase
CRN75_RS02420	COG0246	Mannitol dehydrogenase
CRN75_RS02425	COG2721	sulfolactate sulfo-lyase activity
CRN75_RS02435	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
CRN75_RS02440	COG0861	Integral membrane protein TerC family
CRN75_RS02445	COG0673	inositol 2-dehydrogenase activity
CRN75_RS02450	COG1451	nucleotide metabolic process
CRN75_RS02460	COG2813	Specifically methylates the guanine in position
CRN75_RS02465	COG1902	pentaerythritol trinitrate reductase activity
CRN75_RS02465	COG0446	pyridine nucleotide-disulphide oxidoreductase
CRN75_RS02475	COG2378	regulation of single-species biofilm formation
CRN75_RS02480	COG3247	response to pH
CRN75_RS02490	COG0076	glutamate decarboxylase activity
CRN75_RS02495	COG0531	amino acid
CRN75_RS02505	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CRN75_RS02505	COG1263	PTS System
CRN75_RS02510	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CRN75_RS02520	COG1472	Belongs to the glycosyl hydrolase 3 family
CRN75_RS02530	COG3876	Protein conserved in bacteria
CRN75_RS02545	COG0358	DNA primase activity
CRN75_RS02550	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CRN75_RS02555	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CRN75_RS02560	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CRN75_RS02565	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CRN75_RS02570	COG1968	undecaprenyl-diphosphatase activity
CRN75_RS02575	COG0617	tRNA 3'-terminal CCA addition
CRN75_RS02580	COG4991	sh3 domain protein
CRN75_RS02585	COG3025	triphosphatase activity
CRN75_RS02590	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
CRN75_RS02595	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CRN75_RS02595	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
CRN75_RS02600	COG0531	amino acid
CRN75_RS02610	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CRN75_RS02615	COG3384	dioxygenase
CRN75_RS02620	COG0754	glutathionylspermidine amidase activity
CRN75_RS02625	COG5463	Belongs to the UPF0441 family
CRN75_RS02630	COG1538	Outer membrane efflux protein
CRN75_RS02635	COG0494	nUDIX hydrolase
CRN75_RS02640	COG3151	Protein conserved in bacteria
CRN75_RS02645	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CRN75_RS02650	COG3150	esterase
CRN75_RS02665	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
CRN75_RS02670	COG2249	NAD(P)H dehydrogenase (quinone) activity
CRN75_RS02685	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CRN75_RS02695	COG2132	Multicopper oxidase
CRN75_RS02705	COG0656	L-ascorbic acid biosynthetic process
CRN75_RS02710	COG1979	alcohol dehydrogenase
CRN75_RS02715	COG2207	Transcriptional regulator
CRN75_RS02720	COG0586	Pfam SNARE associated Golgi protein
CRN75_RS02725	COG0626	cystathionine gamma-synthase activity
CRN75_RS02735	COG0848	biopolymer transport protein
CRN75_RS02775	COG4964	Belongs to the GSP D family
CRN75_RS02805	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CRN75_RS02810	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CRN75_RS02830	COG4774	siderophore transport
CRN75_RS02840	COG3251	PFAM MbtH domain protein
CRN75_RS02845	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CRN75_RS02855	COG1120	ATPase activity
CRN75_RS02860	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CRN75_RS02865	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CRN75_RS02875	COG4592	Periplasmic binding protein
CRN75_RS02880	COG1169	isochorismate synthase
CRN75_RS02885	COG1021	2,3-dihydroxybenzoate-AMP ligase
CRN75_RS02890	COG1535	isochorismatase
CRN75_RS02890	COG3433	isochorismatase activity
CRN75_RS02895	COG1028	Short-chain dehydrogenase reductase Sdr
CRN75_RS02900	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CRN75_RS02905	COG0840	transmembrane signaling receptor activity
CRN75_RS02960	COG4964	Belongs to the GSP D family
CRN75_RS03005	COG3133	Outer membrane lipoprotein
CRN75_RS03010	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
CRN75_RS03015	COG0437	4 iron, 4 sulfur cluster binding
CRN75_RS03020	COG5557	Pfam Polysulphide reductase, NrfD
CRN75_RS03025	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
CRN75_RS03030	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
CRN75_RS03035	COG1773	rubredoxin
CRN75_RS03045	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CRN75_RS03050	COG0298	carbon dioxide binding
CRN75_RS03055	COG0409	Hydrogenase expression formation protein
CRN75_RS03060	COG0309	Hydrogenase expression formation protein (HypE)
CRN75_RS03065	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
CRN75_RS03070	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
CRN75_RS03080	COG5001	Diguanylate cyclase
CRN75_RS03085	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CRN75_RS03100	COG4303	Ethanolamine ammonia lyase large subunit
CRN75_RS03105	COG4302	ethanolamine ammonia-lyase activity
CRN75_RS03110	COG0477	Major facilitator Superfamily
CRN75_RS03135	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
CRN75_RS03140	COG2195	Cleaves the N-terminal amino acid of tripeptides
CRN75_RS03145	COG1283	sodium-dependent phosphate transmembrane transporter activity
CRN75_RS03155	COG1609	Transcriptional regulator
CRN75_RS03160	COG0477	Major facilitator Superfamily
CRN75_RS03165	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CRN75_RS03165	COG1017	nitric oxide dioxygenase activity
CRN75_RS03180	COG4607	ABC-type enterochelin transport system periplasmic component
CRN75_RS03190	COG4605	iron ion homeostasis
CRN75_RS03195	COG4604	ABC transporter, ATP-binding protein
CRN75_RS03225	COG1289	transmembrane transporter activity
CRN75_RS03255	COG3047	cAMP biosynthetic process
CRN75_RS03255	COG2885	chlorophyll binding
CRN75_RS03280	COG3501	Rhs element vgr protein
CRN75_RS03370	COG1472	Belongs to the glycosyl hydrolase 3 family
CRN75_RS03375	COG2211	Major facilitator Superfamily
CRN75_RS03390	COG3121	Chaperone
CRN75_RS03405	COG3539	Fimbrial protein
CRN75_RS03410	COG3188	usher protein
CRN75_RS03415	COG3121	Chaperone
CRN75_RS03425	COG0583	DNA-binding transcription factor activity
CRN75_RS03430	COG0640	Transcriptional regulator
CRN75_RS03435	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CRN75_RS03455	COG1022	Amp-dependent synthetase and ligase
CRN75_RS03480	COG3038	cytochrome b561
CRN75_RS03485	COG0789	Transcriptional regulator
CRN75_RS03495	COG1028	Short-chain dehydrogenase reductase Sdr
CRN75_RS03510	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CRN75_RS03525	COG3300	MHYT domain
CRN75_RS03525	COG5001	Diguanylate cyclase
CRN75_RS03545	COG1470	cell adhesion involved in biofilm formation
CRN75_RS03545	COG1388	LysM domain
CRN75_RS03550	COG1802	Transcriptional regulator
CRN75_RS03555	COG0246	Mannitol dehydrogenase
CRN75_RS03560	COG0477	Major facilitator Superfamily
CRN75_RS03565	COG1063	alcohol dehydrogenase
CRN75_RS03570	COG4948	Mandelate Racemase Muconate Lactonizing
CRN75_RS03590	COG0437	4 iron, 4 sulfur cluster binding
CRN75_RS03595	COG0243	molybdopterin cofactor binding
CRN75_RS03615	COG1982	Orn Lys Arg decarboxylase major
CRN75_RS03625	COG0741	lytic transglycosylase activity
CRN75_RS03635	COG1194	a g-specific adenine glycosylase
CRN75_RS03640	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CRN75_RS03645	COG3171	Protein conserved in bacteria
CRN75_RS03660	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CRN75_RS03665	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CRN75_RS03670	COG1872	DUF167
CRN75_RS03675	COG0762	integral membrane protein
CRN75_RS03680	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CRN75_RS03685	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CRN75_RS03690	COG2805	Type II/IV secretion system protein
CRN75_RS03700	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CRN75_RS03705	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CRN75_RS03710	COG1678	Uncharacterized ACR, COG1678
CRN75_RS03715	COG3468	outer membrane autotransporter barrel domain protein
CRN75_RS03720	COG0189	ligase activity
CRN75_RS03725	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CRN75_RS03730	COG2356	endonuclease I
CRN75_RS03735	COG3091	SprT-like family
CRN75_RS03740	COG0640	Transcriptional regulator
CRN75_RS03760	COG1166	arginine decarboxylase activity
CRN75_RS03770	COG0501	Belongs to the peptidase M48B family
CRN75_RS03775	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CRN75_RS03780	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CRN75_RS03785	COG0126	phosphoglycerate kinase activity
CRN75_RS03790	COG0191	fructose-bisphosphate aldolase activity
CRN75_RS03805	COG1279	arginine transmembrane transporter activity
CRN75_RS03815	COG0583	DNA-binding transcription factor activity
CRN75_RS03820	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CRN75_RS03825	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CRN75_RS03830	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CRN75_RS03845	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
CRN75_RS03855	COG3079	Belongs to the UPF0149 family
CRN75_RS03860	COG0006	proline dipeptidase activity
CRN75_RS03865	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CRN75_RS03870	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CRN75_RS03875	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CRN75_RS03880	COG0509	glycine decarboxylation via glycine cleavage system
CRN75_RS03885	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CRN75_RS03885	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CRN75_RS03900	COG1272	protein, Hemolysin III
CRN75_RS03905	COG0354	folic acid binding
CRN75_RS03920	COG0745	RESPONSE REGULATOR receiver
CRN75_RS03925	COG2205	protein histidine kinase activity
CRN75_RS03930	COG4452	Inner membrane protein CreD
CRN75_RS03935	COG0716	FMN binding
CRN75_RS03940	COG4974	Belongs to the 'phage' integrase family
CRN75_RS03945	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CRN75_RS03950	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CRN75_RS03985	COG1566	PFAM secretion protein HlyD family protein
CRN75_RS03995	COG3706	GGDEF domain
CRN75_RS04000	COG1522	sequence-specific DNA binding
CRN75_RS04015	COG2271	Major facilitator Superfamily
CRN75_RS04020	COG1609	Transcriptional regulator
CRN75_RS04025	COG0484	heat shock protein binding
CRN75_RS04035	COG1028	Short-chain dehydrogenase reductase Sdr
CRN75_RS04040	COG1733	regulation of RNA biosynthetic process
CRN75_RS04045	COG0288	reversible hydration of carbon dioxide
CRN75_RS04080	COG2165	general secretion pathway protein
CRN75_RS04140	COG0583	DNA-binding transcription factor activity
CRN75_RS04145	COG2814	Major facilitator Superfamily
CRN75_RS04150	COG0583	DNA-binding transcription factor activity
CRN75_RS04160	COG1609	Transcriptional regulator
CRN75_RS04165	COG1609	Transcriptional regulator
CRN75_RS04175	COG0204	Acyl-transferase
CRN75_RS04175	COG0318	PFAM AMP-dependent synthetase and ligase
CRN75_RS04180	COG0477	Major facilitator Superfamily
CRN75_RS04185	COG0667	Aldo Keto reductase
CRN75_RS04195	COG0861	Integral membrane protein TerC family
CRN75_RS04200	COG3066	DNA modification
CRN75_RS04210	COG1051	belongs to the nudix hydrolase family
CRN75_RS04215	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
CRN75_RS04220	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CRN75_RS04225	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CRN75_RS04230	COG2165	general secretion pathway protein
CRN75_RS04250	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
CRN75_RS04255	COG1025	Belongs to the peptidase M16 family
CRN75_RS04260	COG1074	ATP-dependent DNA helicase activity
CRN75_RS04265	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CRN75_RS04270	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
CRN75_RS04270	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CRN75_RS04275	COG0860	N-Acetylmuramoyl-L-alanine amidase
CRN75_RS04295	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
CRN75_RS04300	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CRN75_RS04305	COG2166	iron-sulfur cluster assembly
CRN75_RS04310	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CRN75_RS04320	COG0583	DNA-binding transcription factor activity
CRN75_RS04325	COG2363	Small membrane protein
CRN75_RS04330	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
CRN75_RS04335	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CRN75_RS04345	COG1611	Belongs to the LOG family
CRN75_RS04350	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CRN75_RS04350	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CRN75_RS04365	COG3098	single-species biofilm formation
CRN75_RS04370	COG0564	pseudouridine synthase activity
CRN75_RS04390	COG2171	N-acyltransferase activity
CRN75_RS04395	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
CRN75_RS04410	COG0052	Belongs to the universal ribosomal protein uS2 family
CRN75_RS04415	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CRN75_RS04420	COG0528	UMP kinase activity
CRN75_RS04425	COG0233	cytoplasmic translational termination
CRN75_RS04430	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CRN75_RS04440	COG0575	Belongs to the CDS family
CRN75_RS04445	COG0750	zinc metalloprotease
CRN75_RS04455	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
CRN75_RS04460	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CRN75_RS04465	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CRN75_RS04470	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CRN75_RS04480	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CRN75_RS04485	COG0587	DNA-directed DNA polymerase activity
CRN75_RS04490	COG0825	malonyl-CoA metabolic process
CRN75_RS04495	COG1982	Orn Lys Arg decarboxylase major
CRN75_RS04500	COG0346	lactoylglutathione lyase activity
CRN75_RS04515	COG4568	rho-dependent transcription termination
CRN75_RS04525	COG4681	YaeQ
CRN75_RS04535	COG3015	lipoprotein NlpE involved in copper resistance
CRN75_RS04540	COG0442	prolyl-tRNA aminoacylation
CRN75_RS04550	COG1720	tRNA m6t6A37 methyltransferase activity
CRN75_RS04560	COG1464	Belongs to the NlpA lipoprotein family
CRN75_RS04565	COG2011	ABC-type metal ion transport system permease component
CRN75_RS04575	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CRN75_RS04630	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CRN75_RS04635	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CRN75_RS04680	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CRN75_RS04690	COG1028	Short-chain dehydrogenase reductase Sdr
CRN75_RS04700	COG0656	L-ascorbic acid biosynthetic process
CRN75_RS04705	COG0583	DNA-binding transcription factor activity
CRN75_RS04710	COG2814	Major facilitator Superfamily
CRN75_RS04715	COG3021	interspecies interaction between organisms
CRN75_RS04720	COG0741	lytic transglycosylase activity
CRN75_RS04720	COG1388	LysM domain
CRN75_RS04725	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CRN75_RS04730	COG2226	methyltransferase
CRN75_RS04735	COG0328	RNA-DNA hybrid ribonuclease activity
CRN75_RS04750	COG2113	Glycine betaine
CRN75_RS04755	COG4176	ABC-type proline glycine betaine transport system permease component
CRN75_RS04760	COG4175	Glycine betaine
CRN75_RS04765	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CRN75_RS04775	COG1780	Probably involved in ribonucleotide reductase function
CRN75_RS04780	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CRN75_RS04790	COG4575	ribosome binding
CRN75_RS04810	COG3708	Transcriptional regulator
CRN75_RS04810	COG2207	Transcriptional regulator
CRN75_RS04830	COG1278	Cold shock
CRN75_RS04865	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CRN75_RS04870	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CRN75_RS04875	COG1124	(ABC) transporter
CRN75_RS04885	COG0831	urea catabolic process
CRN75_RS04895	COG0804	urea catabolic process
CRN75_RS04910	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CRN75_RS04920	COG4413	Urea transporter
CRN75_RS04925	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
CRN75_RS04935	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CRN75_RS04950	COG0667	Aldo Keto reductase
CRN75_RS04955	COG2133	pyrroloquinoline quinone binding
CRN75_RS04960	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CRN75_RS04965	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CRN75_RS04970	COG2723	6-phospho-beta-galactosidase activity
CRN75_RS04975	COG1447	Phosphotransferase system cellobiose-specific component IIA
CRN75_RS04980	COG2169	Transcriptional regulator
CRN75_RS04980	COG1917	Cupin 2, conserved barrel domain protein
CRN75_RS04985	COG3394	polysaccharide catabolic process
CRN75_RS04995	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CRN75_RS05000	COG2271	Major facilitator Superfamily
CRN75_RS05005	COG2721	sulfolactate sulfo-lyase activity
CRN75_RS05035	COG2867	negative regulation of translational initiation
CRN75_RS05045	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CRN75_RS05050	COG0497	DNA recombination
CRN75_RS05055	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CRN75_RS05060	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CRN75_RS05065	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CRN75_RS05070	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
CRN75_RS05085	COG0513	Belongs to the DEAD box helicase family
CRN75_RS05090	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CRN75_RS05095	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CRN75_RS05105	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
CRN75_RS05110	COG3026	antisigma factor binding
CRN75_RS05115	COG3086	response to oxidative stress
CRN75_RS05125	COG0481	GTPase activity
CRN75_RS05140	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CRN75_RS05145	COG1381	Involved in DNA repair and RecF pathway recombination
CRN75_RS05165	COG2610	gluconate transmembrane transporter activity
CRN75_RS05170	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CRN75_RS05175	COG1737	Transcriptional regulator
CRN75_RS05185	COG0560	Phosphoserine phosphatase
CRN75_RS05200	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
CRN75_RS05225	COG2205	protein histidine kinase activity
CRN75_RS05230	COG3170	Tfp pilus assembly protein FimV
CRN75_RS05235	COG2204	response regulator
CRN75_RS05240	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CRN75_RS05240	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CRN75_RS05245	COG0347	Belongs to the P(II) protein family
CRN75_RS05260	COG1735	metal-dependent hydrolase with the TIM-barrel fold
CRN75_RS05265	COG3457	Alanine racemase
CRN75_RS05275	COG2188	Transcriptional regulator
CRN75_RS05280	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CRN75_RS05280	COG1017	nitric oxide dioxygenase activity
CRN75_RS05285	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CRN75_RS05290	COG2814	Major facilitator Superfamily
CRN75_RS05295	COG3711	transcriptional antiterminator
CRN75_RS05300	COG3683	transport system, periplasmic component
CRN75_RS05305	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
CRN75_RS05315	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
CRN75_RS05320	COG1959	2 iron, 2 sulfur cluster binding
CRN75_RS05330	COG0822	iron-sulfur transferase activity
CRN75_RS05350	COG0443	Heat shock 70 kDa protein
CRN75_RS05355	COG0633	Ferredoxin
CRN75_RS05360	COG2975	iron-sulfur cluster assembly
CRN75_RS05375	COG3468	outer membrane autotransporter barrel domain protein
CRN75_RS05380	COG2373	Large extracellular alpha-helical protein
CRN75_RS05385	COG4953	penicillin-binding protein 1C
CRN75_RS05410	COG1426	Protein conserved in bacteria
CRN75_RS05420	COG0124	histidyl-tRNA synthetase
CRN75_RS05425	COG2976	Protein conserved in bacteria
CRN75_RS05430	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CRN75_RS05435	COG1160	GTP binding
CRN75_RS05445	COG1645	bacterial-type flagellum-dependent swarming motility
CRN75_RS05450	COG1570	exodeoxyribonuclease VII activity
CRN75_RS05455	COG0517	IMP dehydrogenase activity
CRN75_RS05455	COG0516	GMP reductase activity
CRN75_RS05460	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CRN75_RS05460	COG0519	Catalyzes the synthesis of GMP from XMP
CRN75_RS05495	COG0351	phosphomethylpyrimidine kinase
CRN75_RS05515	COG1349	DNA-binding transcription factor activity
CRN75_RS05520	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
CRN75_RS05525	COG1028	Short-chain dehydrogenase reductase Sdr
CRN75_RS05540	COG3730	PTS system glucitol sorbitol-specific
CRN75_RS05545	COG1597	lipid kinase activity
CRN75_RS05555	COG0826	peptidase U32
CRN75_RS05560	COG3422	double-strand break repair
CRN75_RS05565	COG0745	RESPONSE REGULATOR receiver
CRN75_RS05570	COG2205	protein histidine kinase activity
CRN75_RS05575	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CRN75_RS05585	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CRN75_RS05590	COG0443	Heat shock 70 kDa protein
CRN75_RS05595	COG3447	MASE1 domain protein
CRN75_RS05595	COG5001	Diguanylate cyclase
CRN75_RS05595	COG5002	protein histidine kinase activity
CRN75_RS05600	COG2239	Acts as a magnesium transporter
CRN75_RS05610	COG0248	Ppx GppA phosphatase
CRN75_RS05615	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CRN75_RS05620	COG0573	inorganic phosphate transmembrane transporter activity
CRN75_RS05625	COG0581	inorganic phosphate transmembrane transporter activity
CRN75_RS05645	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CRN75_RS05650	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CRN75_RS05655	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CRN75_RS05660	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CRN75_RS05665	COG2233	PERMEase
CRN75_RS05670	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CRN75_RS05675	COG1393	Belongs to the ArsC family
CRN75_RS05680	COG4783	chaperone-mediated protein folding
CRN75_RS05685	COG0628	permease
CRN75_RS05690	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CRN75_RS05695	COG2716	regulation of RNA biosynthetic process
CRN75_RS05700	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CRN75_RS05705	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
CRN75_RS05715	COG2321	neutral zinc metallopeptidase
CRN75_RS05720	COG2707	UPF0756 membrane protein
CRN75_RS05725	COG1444	tRNA N-acetyltransferase activity
CRN75_RS05735	COG0400	carboxylic ester hydrolase activity
CRN75_RS05745	COG1876	peptidase activity
CRN75_RS05750	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CRN75_RS05755	COG1393	Belongs to the ArsC family
CRN75_RS05765	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CRN75_RS05775	COG2197	response regulator
CRN75_RS05785	COG3062	negative regulation of establishment of protein localization
CRN75_RS05790	COG0243	molybdopterin cofactor binding
CRN75_RS05795	COG3043	anaerobic respiration
CRN75_RS05800	COG3005	denitrification pathway
CRN75_RS05805	COG0494	nUDIX hydrolase
CRN75_RS05815	COG1671	Belongs to the UPF0178 family
CRN75_RS05820	COG0408	coproporphyrinogen oxidase activity
CRN75_RS05825	COG0456	acetyltransferase
CRN75_RS05830	COG3111	PFAM Bacterial OB fold (BOF) protein
CRN75_RS05840	COG2837	iron assimilation
CRN75_RS05845	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CRN75_RS05860	COG2731	YhcH YjgK YiaL family protein
CRN75_RS05870	COG1737	Transcriptional regulator
CRN75_RS05885	COG4150	thiosulfate binding
CRN75_RS05890	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
CRN75_RS05895	COG4208	sulfate ABC transporter
CRN75_RS05915	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CRN75_RS05920	COG0745	RESPONSE REGULATOR receiver
CRN75_RS05925	COG2205	protein histidine kinase activity
CRN75_RS05940	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CRN75_RS05950	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
CRN75_RS05960	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CRN75_RS05965	COG3530	Putative quorum-sensing-regulated virulence factor
CRN75_RS05995	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CRN75_RS06020	COG1301	dicarboxylic acid transport
CRN75_RS06035	COG3799	methylaspartate ammonia-lyase activity
CRN75_RS06040	COG4865	methylaspartate mutase activity
CRN75_RS06050	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CRN75_RS06060	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CRN75_RS06060	COG1587	Uroporphyrinogen-III synthase
CRN75_RS06065	COG0583	DNA-binding transcription factor activity
CRN75_RS06070	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
CRN75_RS06070	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
CRN75_RS06080	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CRN75_RS06090	COG1914	H( )-stimulated, divalent metal cation uptake system
CRN75_RS06100	COG0667	Aldo Keto reductase
CRN75_RS06115	COG0837	glucose binding
CRN75_RS06120	COG2223	nitrite transmembrane transporter activity
CRN75_RS06125	COG3279	Response regulator of the LytR AlgR family
CRN75_RS06130	COG3275	phosphorelay sensor kinase activity
CRN75_RS06145	COG0436	Aminotransferase
CRN75_RS06150	COG3038	cytochrome b561
CRN75_RS06160	COG1598	PFAM Uncharacterised protein family UPF0150
CRN75_RS06170	COG3381	protein complex oligomerization
CRN75_RS06175	COG3302	dmso reductase anchor subunit
CRN75_RS06180	COG0437	4 iron, 4 sulfur cluster binding
CRN75_RS06185	COG0243	molybdopterin cofactor binding
CRN75_RS06200	COG2723	6-phospho-beta-galactosidase activity
CRN75_RS06215	COG1280	lysine exporter protein (LysE YggA)
CRN75_RS06235	COG2951	lytic endotransglycosylase activity
CRN75_RS06240	COG0531	amino acid
CRN75_RS06260	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CRN75_RS06265	COG1127	ABC transporter
CRN75_RS06280	COG1902	pentaerythritol trinitrate reductase activity
CRN75_RS06290	COG0626	cystathionine gamma-synthase activity
CRN75_RS06300	COG3038	cytochrome b561
CRN75_RS06305	COG2353	YceI-like domain
CRN75_RS06310	COG1609	Transcriptional regulator
CRN75_RS06320	COG0583	DNA-binding transcription factor activity
CRN75_RS06330	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CRN75_RS06330	COG1263	PTS System
CRN75_RS06335	COG2723	6-phospho-beta-galactosidase activity
CRN75_RS06345	COG1695	Transcriptional regulator
CRN75_RS06350	COG2824	Alkylphosphonate utilization operon protein PhnA
CRN75_RS06370	COG2116	formate transmembrane transporter activity
CRN75_RS06380	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CRN75_RS06385	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CRN75_RS06390	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CRN75_RS06395	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
CRN75_RS06400	COG1138	Cytochrome C-type biogenesis protein
CRN75_RS06405	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CRN75_RS06410	COG3088	subunit of a heme lyase
CRN75_RS06410	COG4235	cytochrome complex assembly
CRN75_RS06415	COG3088	subunit of a heme lyase
CRN75_RS06415	COG4235	cytochrome complex assembly
CRN75_RS06430	COG3691	Protein conserved in bacteria
CRN75_RS06435	COG0183	Belongs to the thiolase family
CRN75_RS06440	COG1024	Enoyl-CoA hydratase
CRN75_RS06440	COG1250	3-hydroxyacyl-CoA dehydrogenase
CRN75_RS06450	COG2062	phosphohistidine phosphatase, SixA
CRN75_RS06455	COG2840	Smr protein MutS2
CRN75_RS06460	COG2890	protein-(glutamine-N5) methyltransferase activity
CRN75_RS06465	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CRN75_RS06470	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
CRN75_RS06475	COG0730	response to heat
CRN75_RS06480	COG3101	peptidyl-lysine hydroxylation
CRN75_RS06490	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CRN75_RS06490	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
CRN75_RS06495	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CRN75_RS06505	COG1794	racemase activity, acting on amino acids and derivatives
CRN75_RS06515	COG1447	Phosphotransferase system cellobiose-specific component IIA
CRN75_RS06520	COG2723	6-phospho-beta-galactosidase activity
CRN75_RS06525	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CRN75_RS06545	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CRN75_RS06560	COG4232	protein-disulfide reductase activity
CRN75_RS06570	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CRN75_RS06575	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CRN75_RS06585	COG0697	spore germination
CRN75_RS06600	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CRN75_RS06610	COG0586	Pfam SNARE associated Golgi protein
CRN75_RS06615	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CRN75_RS06620	COG0285	dihydrofolate synthase activity
CRN75_RS06625	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
CRN75_RS06630	COG1286	toxin biosynthetic process
CRN75_RS06635	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CRN75_RS06645	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CRN75_RS06650	COG4215	(ABC) transporter
CRN75_RS06655	COG4160	amino acid transport
CRN75_RS06670	COG1090	epimerase
CRN75_RS06680	COG0622	Phosphoesterase
CRN75_RS06685	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
CRN75_RS06690	COG3037	sugar-specific permease SgaT UlaA
CRN75_RS06700	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CRN75_RS06705	COG1609	Transcriptional regulator
CRN75_RS06710	COG0280	phosphate acetyltransferase
CRN75_RS06710	COG0857	belongs to the CobB CobQ family
CRN75_RS06725	COG3092	negative regulation of chromosome organization
CRN75_RS06730	COG3013	Belongs to the UPF0304 family
CRN75_RS06735	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CRN75_RS06745	COG0471	metal ion transport
CRN75_RS06745	COG0490	domain, Protein
CRN75_RS06750	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
CRN75_RS06760	COG0436	Aminotransferase
CRN75_RS06765	COG0583	DNA-binding transcription factor activity
CRN75_RS06770	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CRN75_RS06775	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CRN75_RS06780	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CRN75_RS06780	COG0649	NAD binding
CRN75_RS06795	COG1034	ATP synthesis coupled electron transport
CRN75_RS06800	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CRN75_RS06805	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CRN75_RS06810	COG0839	Belongs to the complex I subunit 6 family
CRN75_RS06815	COG0713	ATP synthesis coupled electron transport
CRN75_RS06820	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CRN75_RS06825	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CRN75_RS06830	COG1007	ATP synthesis coupled electron transport
CRN75_RS06845	COG2731	YhcH YjgK YiaL family protein
CRN75_RS06850	COG3265	gluconokinase activity
CRN75_RS06855	COG1028	Short-chain dehydrogenase reductase Sdr
CRN75_RS06860	COG1609	Transcriptional regulator
CRN75_RS06865	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CRN75_RS06875	COG4702	Belongs to the UPF0303 family
CRN75_RS06880	COG0129	dihydroxy-acid dehydratase activity
CRN75_RS06885	COG4575	ribosome binding
CRN75_RS06890	COG1169	isochorismate synthase
CRN75_RS06895	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
CRN75_RS06900	COG0596	Alpha beta hydrolase
CRN75_RS06905	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CRN75_RS06910	COG1441	menaquinone biosynthetic process
CRN75_RS06920	COG5642	Protein of unknown function (DUF2384)
CRN75_RS06940	COG0814	amino acid
CRN75_RS06950	COG4574	serine-type endopeptidase inhibitor activity
CRN75_RS06955	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CRN75_RS06965	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CRN75_RS06970	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CRN75_RS06980	COG2205	protein histidine kinase activity
CRN75_RS06980	COG0784	Response regulator, receiver
CRN75_RS06990	COG2198	Histidine kinase
CRN75_RS06990	COG0642	Histidine kinase
CRN75_RS06995	COG2223	nitrite transmembrane transporter activity
CRN75_RS07005	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CRN75_RS07020	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CRN75_RS07060	COG3772	lysozyme
CRN75_RS07080	COG4386	tail sheath protein
CRN75_RS07125	COG3299	homolog of phage Mu protein gp47
CRN75_RS07150	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CRN75_RS07155	COG1737	Transcriptional regulator
CRN75_RS07160	COG2190	(PTS) system
CRN75_RS07160	COG1263	PTS System
CRN75_RS07160	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CRN75_RS07165	COG2723	6-phospho-beta-galactosidase activity
CRN75_RS07185	COG3082	Protein of unknown function (DUF1414)
CRN75_RS07190	COG3081	Nucleoid-associated protein
CRN75_RS07200	COG1061	Type III restriction enzyme res subunit
CRN75_RS07205	COG1187	pseudouridine synthase activity
CRN75_RS07210	COG2814	Major facilitator Superfamily
CRN75_RS07225	COG4172	Belongs to the ABC transporter superfamily
CRN75_RS07230	COG4239	(ABC) transporter, permease
CRN75_RS07235	COG4174	ABC transporter (Permease)
CRN75_RS07240	COG4166	transmembrane transport
CRN75_RS07245	COG2200	EAL domain
CRN75_RS07255	COG0791	NLP P60 protein
CRN75_RS07260	COG0671	phosphoesterase, PA-phosphatase related
CRN75_RS07265	COG0523	cobalamin synthesis protein
CRN75_RS07275	COG2186	Transcriptional regulator
CRN75_RS07280	COG0246	Mannitol dehydrogenase
CRN75_RS07290	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CRN75_RS07305	COG0243	molybdopterin cofactor binding
CRN75_RS07310	COG3005	denitrification pathway
CRN75_RS07325	COG1105	Belongs to the carbohydrate kinase PfkB family
CRN75_RS07330	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
CRN75_RS07330	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CRN75_RS07330	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CRN75_RS07335	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
CRN75_RS07340	COG2855	membrane
CRN75_RS07350	COG0583	DNA-binding transcription factor activity
CRN75_RS07355	COG0833	amino acid
CRN75_RS07365	COG4771	TonB-dependent receptor
CRN75_RS07370	COG0625	glutathione transferase activity
CRN75_RS07395	COG2011	ABC-type metal ion transport system permease component
CRN75_RS07410	COG0626	cystathionine gamma-synthase activity
CRN75_RS07420	COG1686	Belongs to the peptidase S11 family
CRN75_RS07430	COG1760	l-serine dehydratase
CRN75_RS07435	COG0814	amino acid
CRN75_RS07440	COG1349	DNA-binding transcription factor activity
CRN75_RS07445	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CRN75_RS07450	COG0671	phosphoesterase, PA-phosphatase related
CRN75_RS07460	COG2985	domain, Protein
CRN75_RS07460	COG0569	domain protein
CRN75_RS07480	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CRN75_RS07485	COG3842	ATPase activity
CRN75_RS07490	COG1176	ABC-type spermidine putrescine transport system, permease component I
CRN75_RS07495	COG1177	transmembrane transport
CRN75_RS07505	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CRN75_RS07510	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CRN75_RS07520	COG4160	amino acid transport
CRN75_RS07525	COG4215	(ABC) transporter
CRN75_RS07530	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CRN75_RS07535	COG1126	abc transporter atp-binding protein
CRN75_RS07540	COG1605	Chorismate mutase
CRN75_RS07555	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CRN75_RS07560	COG0702	epimerase
CRN75_RS07565	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
CRN75_RS07570	COG0028	Belongs to the TPP enzyme family
CRN75_RS07575	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CRN75_RS07580	COG1151	hydroxylamine reductase activity
CRN75_RS07585	COG2431	L-lysine efflux transmembrane transporter activity
CRN75_RS07590	COG3593	DNA synthesis involved in DNA repair
CRN75_RS07595	COG2990	Protein conserved in bacteria
CRN75_RS07600	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CRN75_RS07610	COG1278	Cold shock
CRN75_RS07615	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CRN75_RS07620	COG0542	response to heat
CRN75_RS07625	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CRN75_RS07630	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
CRN75_RS07635	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
CRN75_RS07645	COG0492	ferredoxin-NADP+ reductase activity
CRN75_RS07655	COG1674	ftsk spoiiie
CRN75_RS07655	COG3107	peptidoglycan biosynthetic process
CRN75_RS07660	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
CRN75_RS07665	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CRN75_RS07675	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CRN75_RS07680	COG2814	Major facilitator Superfamily
CRN75_RS07685	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CRN75_RS07690	COG1882	Formate acetyltransferase
CRN75_RS07695	COG2116	formate transmembrane transporter activity
CRN75_RS07700	COG1944	ATP diphosphatase activity
CRN75_RS07705	COG0252	asparaginase activity
CRN75_RS07710	COG2323	membrane
CRN75_RS07715	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CRN75_RS07720	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CRN75_RS07725	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CRN75_RS07730	COG0539	negative regulation of cytoplasmic translation
CRN75_RS07740	COG0658	competence protein
CRN75_RS07740	COG2333	competence protein COMEC
CRN75_RS07750	COG1663	tetraacyldisaccharide 4'-kinase activity
CRN75_RS07755	COG5383	Protein conserved in bacteria
CRN75_RS07765	COG1278	Cold shock
CRN75_RS07770	COG2835	tetraacyldisaccharide 4'-kinase activity
CRN75_RS07780	COG3173	Aminoglycoside phosphotransferase
CRN75_RS07785	COG1434	Gram-negative-bacterium-type cell wall biogenesis
CRN75_RS07790	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CRN75_RS07795	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
CRN75_RS07805	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
CRN75_RS07810	COG2989	Protein conserved in bacteria
CRN75_RS07815	COG3108	Peptidase M15
CRN75_RS07820	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CRN75_RS07825	COG2200	EAL domain
CRN75_RS07830	COG1448	Aminotransferase
CRN75_RS07840	COG0017	Asparaginyl-tRNA synthetase
CRN75_RS07845	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CRN75_RS07850	COG0308	aminopeptidase N
CRN75_RS07855	COG0167	dihydroorotate dehydrogenase activity
CRN75_RS07865	COG0633	Ferredoxin
CRN75_RS07865	COG3217	Mosc domain protein beta barrel domain protein
CRN75_RS07870	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CRN75_RS07870	COG0116	Belongs to the methyltransferase superfamily
CRN75_RS07875	COG0488	(ABC) transporter
CRN75_RS07885	COG3008	intermembrane lipid transfer
CRN75_RS07885	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CRN75_RS07890	COG3009	Protein conserved in bacteria
CRN75_RS07900	COG3130	regulation of translation
CRN75_RS07905	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CRN75_RS07915	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CRN75_RS07920	COG1067	ATP-dependent peptidase activity
CRN75_RS07925	COG3120	sequence-specific DNA binding
CRN75_RS07935	COG5404	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
CRN75_RS07940	COG3070	regulator of competence-specific genes
CRN75_RS07945	COG1289	transmembrane transporter activity
CRN75_RS07950	COG3304	Inner membrane component domain
CRN75_RS07955	COG0210	DNA helicase
CRN75_RS07960	COG1803	Methylglyoxal synthase
CRN75_RS07970	COG1832	CoA-binding protein
CRN75_RS07975	COG3785	DNA binding
CRN75_RS07980	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CRN75_RS07985	COG1254	Belongs to the acylphosphatase family
CRN75_RS07990	COG2920	part of a sulfur-relay system
CRN75_RS08005	COG3069	C4-dicarboxylate transmembrane transporter activity
CRN75_RS08010	COG1737	Transcriptional regulator
CRN75_RS08015	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CRN75_RS08030	COG2771	luxR family
CRN75_RS08035	COG3916	Acyl-homoserine-lactone synthase
CRN75_RS08045	COG2764	glyoxalase bleomycin resistance protein dioxygenase
CRN75_RS08050	COG3263	regulation of cellular component size
CRN75_RS08065	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
CRN75_RS08070	COG2943	transferase activity, transferring hexosyl groups
CRN75_RS08075	COG5645	(Lipo)protein
CRN75_RS08090	COG2814	Major facilitator Superfamily
CRN75_RS08095	COG2259	Doxx family
CRN75_RS08100	COG1560	Kdo2-lipid A biosynthetic process
CRN75_RS08135	COG0697	spore germination
CRN75_RS08145	COG0628	permease
CRN75_RS08175	COG0418	dihydroorotase activity
CRN75_RS08180	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
CRN75_RS08185	COG1530	ribonuclease E activity
CRN75_RS08190	COG0564	pseudouridine synthase activity
CRN75_RS08200	COG1399	metal-binding, possibly nucleic acid-binding protein
CRN75_RS08205	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CRN75_RS08210	COG0416	fatty acid biosynthetic process
CRN75_RS08225	COG1028	Short-chain dehydrogenase reductase Sdr
CRN75_RS08235	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CRN75_RS08240	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CRN75_RS08245	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CRN75_RS08250	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CRN75_RS08255	COG0470	DNA polymerase III
CRN75_RS08260	COG0084	hydrolase, TatD family'
CRN75_RS08265	COG1263	PTS System
CRN75_RS08265	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CRN75_RS08275	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CRN75_RS08280	COG0537	adenosine 5'-monophosphoramidase activity
CRN75_RS08285	COG5633	Lipoprotein
CRN75_RS08290	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
CRN75_RS08295	COG0510	thiamine kinase activity
CRN75_RS08300	COG1472	Belongs to the glycosyl hydrolase 3 family
CRN75_RS08305	COG3150	esterase
CRN75_RS08310	COG1252	NADH dehydrogenase
CRN75_RS08315	COG3134	Outer membrane lipoprotein
CRN75_RS08320	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CRN75_RS08325	COG4591	ABC-type transport system involved in lipoprotein release permease component
CRN75_RS08335	COG4591	ABC-type transport system involved in lipoprotein release permease component
CRN75_RS08340	COG1940	carbohydrate kinase activity
CRN75_RS08355	COG2850	peptidyl-arginine hydroxylation
CRN75_RS08365	COG0745	RESPONSE REGULATOR receiver
CRN75_RS08375	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CRN75_RS08380	COG2915	High frequency lysogenization protein hflD homolog
CRN75_RS08385	COG0482	sulfurtransferase activity
CRN75_RS08395	COG1187	pseudouridine synthase activity
CRN75_RS08400	COG0538	isocitrate dehydrogenase activity
CRN75_RS08415	COG2223	nitrite transmembrane transporter activity
CRN75_RS08435	COG0840	transmembrane signaling receptor activity
CRN75_RS08445	COG2873	o-acetylhomoserine
CRN75_RS08450	COG0702	epimerase
CRN75_RS08455	COG1733	regulation of RNA biosynthetic process
CRN75_RS08480	COG3755	Protein conserved in bacteria
CRN75_RS08490	COG4251	negative regulation of phosphorylation
CRN75_RS08490	COG2203	Gaf domain
CRN75_RS08490	COG3706	GGDEF domain
CRN75_RS08490	COG5001	Diguanylate cyclase
CRN75_RS08500	COG1132	(ABC) transporter
CRN75_RS08520	COG2207	Transcriptional regulator
CRN75_RS08555	COG1113	amino acid transport
CRN75_RS08575	COG1496	oxidoreductase activity
CRN75_RS08585	COG2226	methyltransferase
CRN75_RS08595	COG5002	protein histidine kinase activity
CRN75_RS08595	COG5001	Diguanylate cyclase
CRN75_RS08595	COG3447	MASE1 domain protein
CRN75_RS08605	COG1971	Probably functions as a manganese efflux pump
CRN75_RS08610	COG4811	Protein of unknown function (DUF986)
CRN75_RS08615	COG3716	PTS system mannose fructose sorbose family IID component
CRN75_RS08620	COG3715	PTS system
CRN75_RS08625	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CRN75_RS08625	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
CRN75_RS08630	COG1253	flavin adenine dinucleotide binding
CRN75_RS08635	COG1760	l-serine dehydratase
CRN75_RS08640	COG0494	nUDIX hydrolase
CRN75_RS08655	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
CRN75_RS08660	COG0513	Belongs to the DEAD box helicase family
CRN75_RS08665	COG3141	response to X-ray
CRN75_RS08670	COG3097	Belongs to the UPF0267 family
CRN75_RS08680	COG1770	oligopeptidase
CRN75_RS08685	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CRN75_RS08700	COG1528	Iron-storage protein
CRN75_RS08705	COG2372	response to copper ion
CRN75_RS08710	COG1276	copper resistance
CRN75_RS08720	COG0582	viral genome integration into host DNA
CRN75_RS08815	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CRN75_RS08830	COG3772	lysozyme
CRN75_RS08860	COG1475	DNA binding
CRN75_RS08895	COG3567	Phage-associated protein, HI1409 family
CRN75_RS08905	COG3566	protein conserved in bacteria
CRN75_RS09075	COG3646	Phage regulatory protein
CRN75_RS09110	COG1012	belongs to the aldehyde dehydrogenase family
CRN75_RS09195	COG3459	Glycosyltransferase 36 associated
CRN75_RS09215	COG1072	(Pantothenic acid kinase))
CRN75_RS09225	COG1494	fructose-1,6-bisphosphatase
CRN75_RS09230	COG1063	alcohol dehydrogenase
CRN75_RS09235	COG2213	PTS system mannitol-specific
CRN75_RS09240	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CRN75_RS09255	COG0058	SHG alpha-glucan phosphorylase activity
CRN75_RS09270	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CRN75_RS09280	COG4999	Histidine kinase
CRN75_RS09280	COG3437	response regulator, receiver
CRN75_RS09280	COG2205	protein histidine kinase activity
CRN75_RS09280	COG3850	Histidine kinase
CRN75_RS09305	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
CRN75_RS09310	COG0437	4 iron, 4 sulfur cluster binding
CRN75_RS09315	COG3301	Polysulphide reductase, NrfD
CRN75_RS09320	COG1138	Cytochrome C-type biogenesis protein
CRN75_RS09325	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CRN75_RS09330	COG3088	subunit of a heme lyase
CRN75_RS09335	COG4235	cytochrome complex assembly
CRN75_RS09350	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CRN75_RS09355	COG1737	Transcriptional regulator
CRN75_RS09360	COG1172	Belongs to the binding-protein-dependent transport system permease family
CRN75_RS09365	COG1129	ABC transporter
CRN75_RS09375	COG2115	Belongs to the xylose isomerase family
CRN75_RS09440	COG0667	Aldo Keto reductase
CRN75_RS09455	COG1757	Na H antiporter
CRN75_RS09475	COG4942	peptidase
CRN75_RS09490	COG2222	sugar isomerase
CRN75_RS09495	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CRN75_RS09500	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
CRN75_RS09505	COG3716	PTS system mannose fructose sorbose family IID component
CRN75_RS09515	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CRN75_RS09530	COG1349	DNA-binding transcription factor activity
CRN75_RS09540	COG0738	Major facilitator superfamily
CRN75_RS09545	COG0583	DNA-binding transcription factor activity
CRN75_RS09550	COG2271	Major facilitator Superfamily
CRN75_RS09565	COG4670	ketone body catabolic process
CRN75_RS09570	COG1960	acyl-CoA dehydrogenase activity
CRN75_RS09575	COG1917	Cupin 2, conserved barrel domain protein
CRN75_RS09575	COG2207	Transcriptional regulator
CRN75_RS09580	COG2086	electron transfer activity
CRN75_RS09585	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CRN75_RS09590	COG0644	oxidoreductase
CRN75_RS09595	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
CRN75_RS09600	COG0318	PFAM AMP-dependent synthetase and ligase
CRN75_RS09605	COG2807	transmembrane transport
CRN75_RS09615	COG0288	reversible hydration of carbon dioxide
CRN75_RS09620	COG0583	DNA-binding transcription factor activity
CRN75_RS09625	COG3210	domain, Protein
CRN75_RS09655	COG3210	domain, Protein
CRN75_RS09700	COG3210	domain, Protein
CRN75_RS09730	COG2831	hemolysin activation secretion protein
CRN75_RS09740	COG2801	Transposase and inactivated derivatives
CRN75_RS09780	COG0604	alcohol dehydrogenase
CRN75_RS09785	COG2267	carboxylic ester hydrolase activity
CRN75_RS09790	COG2963	transposase activity
CRN75_RS09795	COG1309	transcriptional regulator
CRN75_RS09825	COG0667	Aldo Keto reductase
CRN75_RS09835	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CRN75_RS09840	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CRN75_RS09860	COG5002	protein histidine kinase activity
CRN75_RS09885	COG0656	L-ascorbic acid biosynthetic process
CRN75_RS09910	COG3328	transposase activity
CRN75_RS09915	COG0582	viral genome integration into host DNA
CRN75_RS09920	COG0012	GTP binding
CRN75_RS09930	COG0193	aminoacyl-tRNA hydrolase activity
CRN75_RS09940	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CRN75_RS09950	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
CRN75_RS09955	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CRN75_RS09960	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CRN75_RS09965	COG2890	protein-(glutamine-N5) methyltransferase activity
CRN75_RS09985	COG0659	secondary active sulfate transmembrane transporter activity
CRN75_RS09990	COG3706	GGDEF domain
CRN75_RS10010	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CRN75_RS10015	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CRN75_RS10020	COG3381	protein complex oligomerization
CRN75_RS10030	COG0477	Major facilitator Superfamily
CRN75_RS10035	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CRN75_RS10050	COG0728	peptidoglycan biosynthetic process
CRN75_RS10055	COG0018	arginyl-trna synthetase
CRN75_RS10060	COG3102	Protein conserved in bacteria
CRN75_RS10065	COG3142	Participates in the control of copper homeostasis
CRN75_RS10070	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CRN75_RS10080	COG3788	relative of glutathione S-transferase, MAPEG superfamily
CRN75_RS10085	COG1801	Protein of unknown function DUF72
CRN75_RS10090	COG1335	isochorismatase
CRN75_RS10105	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CRN75_RS10110	COG0494	nUDIX hydrolase
CRN75_RS10115	COG0217	transcriptional regulatory protein
CRN75_RS10125	COG0632	four-way junction helicase activity
CRN75_RS10130	COG2255	four-way junction helicase activity
CRN75_RS10135	COG3104	oligopeptide transport
CRN75_RS10140	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CRN75_RS10145	COG1121	(ABC) transporter
CRN75_RS10150	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
CRN75_RS10155	COG0739	heme binding
CRN75_RS10160	COG1560	Kdo2-lipid A biosynthetic process
CRN75_RS10170	COG1737	Transcriptional regulator
CRN75_RS10175	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CRN75_RS10180	COG0800	Aldolase
CRN75_RS10185	COG2076	Multidrug Resistance protein
CRN75_RS10190	COG2076	Multidrug Resistance protein
CRN75_RS10195	COG0251	oxidation-reduction process
CRN75_RS10200	COG1199	ATP-dependent helicase activity
CRN75_RS10210	COG3065	identical protein binding
CRN75_RS10215	COG0318	PFAM AMP-dependent synthetase and ligase
CRN75_RS10220	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
CRN75_RS10225	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
CRN75_RS10230	COG2894	cell division
CRN75_RS10235	COG0850	regulation of cytokinetic process
CRN75_RS10245	COG3100	YcgL domain-containing protein
CRN75_RS10250	COG2951	lytic endotransglycosylase activity
CRN75_RS10255	COG0179	Fumarylacetoacetate (FAA) hydrolase
CRN75_RS10260	COG2983	Belongs to the UPF0260 family
CRN75_RS10270	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CRN75_RS10275	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
CRN75_RS10280	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CRN75_RS10290	COG2186	Transcriptional regulator
CRN75_RS10295	COG2719	SpoVR family
CRN75_RS10300	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CRN75_RS10305	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CRN75_RS10310	COG2814	Major facilitator Superfamily
CRN75_RS10315	COG2202	Pas domain
CRN75_RS10315	COG2200	EAL domain
CRN75_RS10315	COG2199	diguanylate cyclase activity
CRN75_RS10325	COG0583	DNA-binding transcription factor activity
CRN75_RS10335	COG2718	Belongs to the UPF0229 family
CRN75_RS10340	COG2766	serine protein kinase
CRN75_RS10350	COG3713	MltA-interacting MipA family protein
CRN75_RS10370	COG3139	Protein of unknown function (DUF1315)
CRN75_RS10375	COG1335	isochorismatase
CRN75_RS10380	COG0252	asparaginase activity
CRN75_RS10385	COG0616	signal peptide processing
CRN75_RS10390	COG0778	Nitroreductase
CRN75_RS10400	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CRN75_RS10410	COG0494	nUDIX hydrolase
CRN75_RS10415	COG0708	Exodeoxyribonuclease III
CRN75_RS10420	COG0583	DNA-binding transcription factor activity
CRN75_RS10440	COG0788	formyltetrahydrofolate deformylase activity
CRN75_RS10445	COG3012	SEC-C Motif Domain Protein
CRN75_RS10455	COG1752	Esterase of the alpha-beta hydrolase superfamily
CRN75_RS10460	COG0745	RESPONSE REGULATOR receiver
CRN75_RS10470	COG2916	Histone family protein nucleoid-structuring protein H-NS
CRN75_RS10485	COG1012	belongs to the aldehyde dehydrogenase family
CRN75_RS10485	COG1454	alcohol dehydrogenase
CRN75_RS10495	COG2095	MarC family integral membrane protein
CRN75_RS10500	COG4166	transmembrane transport
CRN75_RS10515	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CRN75_RS10520	COG0444	Belongs to the ABC transporter superfamily
CRN75_RS10530	COG3099	Belongs to the UPF0263 family
CRN75_RS10535	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CRN75_RS10545	COG2200	EAL domain
CRN75_RS10555	COG2350	Protein conserved in bacteria
CRN75_RS10560	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
CRN75_RS10570	COG2917	probably involved in intracellular septation
CRN75_RS10585	COG0727	PFAM Uncharacterised protein family (UPF0153)
CRN75_RS10590	COG3047	cAMP biosynthetic process
CRN75_RS10600	COG0159	tryptophan synthase activity
CRN75_RS10605	COG0133	tryptophan synthase activity
CRN75_RS10610	COG0134	indole-3-glycerol-phosphate synthase activity
CRN75_RS10610	COG0135	phosphoribosylanthranilate isomerase activity
CRN75_RS10620	COG0512	Glutamine amidotransferase of anthranilate synthase
CRN75_RS10630	COG0613	PHP domain protein
CRN75_RS10635	COG0009	L-threonylcarbamoyladenylate synthase
CRN75_RS10655	COG1470	cell adhesion involved in biofilm formation
CRN75_RS10655	COG1388	LysM domain
CRN75_RS10670	COG2197	response regulator
CRN75_RS10740	COG1187	pseudouridine synthase activity
CRN75_RS10755	COG1028	Short-chain dehydrogenase reductase Sdr
CRN75_RS10760	COG0616	signal peptide processing
CRN75_RS10780	COG0583	DNA-binding transcription factor activity
CRN75_RS10790	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CRN75_RS10800	COG0671	phosphoesterase, PA-phosphatase related
CRN75_RS10805	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
CRN75_RS10810	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
CRN75_RS10830	COG0023	Translation Initiation Factor
CRN75_RS10845	COG0235	Class ii aldolase
CRN75_RS10855	COG1349	DNA-binding transcription factor activity
CRN75_RS10860	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CRN75_RS10865	COG2879	small protein
CRN75_RS10870	COG1966	Carbon starvation protein
CRN75_RS10875	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
CRN75_RS10880	COG0243	molybdopterin cofactor binding
CRN75_RS10885	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CRN75_RS10895	COG4659	FMN binding
CRN75_RS10900	COG4658	electron transport chain
CRN75_RS10905	COG3708	Transcriptional regulator
CRN75_RS10905	COG2207	Transcriptional regulator
CRN75_RS10910	COG4656	Part of a membrane complex involved in electron transport
CRN75_RS10920	COG4657	Part of a membrane complex involved in electron transport
CRN75_RS10930	COG2759	Belongs to the formate--tetrahydrofolate ligase family
CRN75_RS10935	COG2274	protein secretion by the type I secretion system
CRN75_RS10950	COG2723	6-phospho-beta-galactosidase activity
CRN75_RS10955	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CRN75_RS10970	COG1879	ABC-type sugar transport system periplasmic component
CRN75_RS10975	COG1129	ABC transporter
CRN75_RS10980	COG1172	Belongs to the binding-protein-dependent transport system permease family
CRN75_RS10990	COG0673	inositol 2-dehydrogenase activity
CRN75_RS10995	COG0385	Bile acid
CRN75_RS11000	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CRN75_RS11020	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CRN75_RS11025	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CRN75_RS11025	COG1263	PTS System
CRN75_RS11030	COG1609	Transcriptional regulator
CRN75_RS11040	COG0583	DNA-binding transcription factor activity
CRN75_RS11045	COG5339	Protein conserved in bacteria
CRN75_RS11055	COG0114	fumarate hydratase activity
CRN75_RS11060	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CRN75_RS11065	COG0698	ribose 5-phosphate isomerase
CRN75_RS11070	COG1263	PTS System
CRN75_RS11070	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CRN75_RS11070	COG2190	(PTS) system
CRN75_RS11075	COG1737	Transcriptional regulator
CRN75_RS11095	COG2814	Major facilitator Superfamily
CRN75_RS11100	COG0583	DNA-binding transcription factor activity
CRN75_RS11105	COG1940	carbohydrate kinase activity
CRN75_RS11110	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CRN75_RS11130	COG1742	UPF0060 membrane protein
CRN75_RS11140	COG4221	oxidoreductase activity
CRN75_RS11145	COG0477	Major facilitator Superfamily
CRN75_RS11155	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CRN75_RS11160	COG2207	Transcriptional regulator
CRN75_RS11180	COG0625	glutathione transferase activity
CRN75_RS11190	COG1522	sequence-specific DNA binding
CRN75_RS11220	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CRN75_RS11240	COG3023	N-Acetylmuramoyl-L-alanine amidase
CRN75_RS11255	COG0028	Belongs to the TPP enzyme family
CRN75_RS11260	COG0440	acetolactate synthase activity
CRN75_RS11265	COG1011	Hydrolase
CRN75_RS11275	COG0583	DNA-binding transcription factor activity
CRN75_RS11290	COG0738	Major facilitator superfamily
CRN75_RS11295	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CRN75_RS11310	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
CRN75_RS11325	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CRN75_RS11330	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CRN75_RS11335	COG0589	response to stress
CRN75_RS11340	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
CRN75_RS11345	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
CRN75_RS11355	COG0531	amino acid
CRN75_RS11365	COG0745	RESPONSE REGULATOR receiver
CRN75_RS11370	COG2205	protein histidine kinase activity
CRN75_RS11375	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
CRN75_RS11390	COG3591	Belongs to the peptidase S1B family
CRN75_RS11400	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
CRN75_RS11405	COG1643	Atp-dependent helicase
CRN75_RS11410	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CRN75_RS11415	COG2390	Transcriptional regulator
CRN75_RS11420	COG0246	Mannitol dehydrogenase
CRN75_RS11425	COG1070	Carbohydrate kinase
CRN75_RS11435	COG3784	Protein of unknown function (DUF1318)
CRN75_RS11445	COG2911	Protein conserved in bacteria
CRN75_RS11450	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CRN75_RS11455	COG3042	response to heat
CRN75_RS11470	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CRN75_RS11470	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CRN75_RS11470	COG0674	pyruvate-flavodoxin oxidoreductase activity
CRN75_RS11470	COG1013	pyruvate-flavodoxin oxidoreductase activity
CRN75_RS11480	COG0037	tRNA processing
CRN75_RS11500	COG4166	transmembrane transport
CRN75_RS11505	COG2866	Carboxypeptidase
CRN75_RS11510	COG4948	Mandelate Racemase Muconate Lactonizing
CRN75_RS11515	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CRN75_RS11525	COG5642	Protein of unknown function (DUF2384)
CRN75_RS11530	COG5654	RES domain protein
CRN75_RS11535	COG3768	UPF0283 membrane protein
CRN75_RS11540	COG3106	COG3106 Predicted ATPase
CRN75_RS11550	COG1983	PspC domain protein
CRN75_RS11560	COG1842	Phage shock protein A
CRN75_RS11565	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
CRN75_RS11575	COG4166	transmembrane transport
CRN75_RS11580	COG4168	peptide transport system, permease
CRN75_RS11585	COG4171	peptide transport system, permease
CRN75_RS11595	COG4172	Belongs to the ABC transporter superfamily
CRN75_RS11605	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CRN75_RS11605	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CRN75_RS11615	COG3104	oligopeptide transport
CRN75_RS11640	COG0625	glutathione transferase activity
CRN75_RS11655	COG0259	pyridoxamine-phosphate oxidase activity
CRN75_RS11660	COG3895	Periplasmic Protein
CRN75_RS11665	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
CRN75_RS11670	COG3133	Outer membrane lipoprotein
CRN75_RS11675	COG1846	Transcriptional regulator
CRN75_RS11685	COG1566	PFAM secretion protein HlyD family protein
CRN75_RS11690	COG1289	transmembrane transporter activity
CRN75_RS11695	COG4989	oxidoreductase activity
CRN75_RS11700	COG3313	Fe-S protein
CRN75_RS11705	COG2194	sulfuric ester hydrolase activity
CRN75_RS11710	COG1309	transcriptional regulator
CRN75_RS11715	COG1902	pentaerythritol trinitrate reductase activity
CRN75_RS11720	COG0346	lactoylglutathione lyase activity
CRN75_RS11725	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CRN75_RS11730	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CRN75_RS11740	COG0791	NLP P60 protein
CRN75_RS11755	COG1609	Transcriptional regulator
CRN75_RS11760	COG0583	DNA-binding transcription factor activity
CRN75_RS11765	COG2814	Major facilitator Superfamily
CRN75_RS11770	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CRN75_RS11775	COG0307	riboflavin synthase, alpha
CRN75_RS11780	COG0534	Mate efflux family protein
CRN75_RS11820	COG1309	transcriptional regulator
CRN75_RS11825	COG1388	LysM domain
CRN75_RS11825	COG1376	ErfK ybiS ycfS ynhG family protein
CRN75_RS11830	COG2166	iron-sulfur cluster assembly
CRN75_RS11840	COG0719	Fe-S assembly protein
CRN75_RS11845	COG0396	ATPase activity
CRN75_RS11850	COG0719	Fe-S assembly protein
CRN75_RS11855	COG0316	Belongs to the HesB IscA family
CRN75_RS11860	COG2050	protein possibly involved in aromatic compounds catabolism
CRN75_RS11865	COG0277	FAD linked oxidase domain protein
CRN75_RS11865	COG0247	lactate metabolic process
CRN75_RS11870	COG0628	permease
CRN75_RS11880	COG0574	Belongs to the PEP-utilizing enzyme family
CRN75_RS11880	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CRN75_RS11890	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CRN75_RS11905	COG4771	TonB-dependent receptor
CRN75_RS11910	COG3720	iron ion transport
CRN75_RS11915	COG4558	Periplasmic binding protein
CRN75_RS11925	COG0095	Lipoate-protein ligase
CRN75_RS11930	COG0791	NLP P60 protein
CRN75_RS11935	COG2076	Multidrug Resistance protein
CRN75_RS11940	COG2076	Multidrug Resistance protein
CRN75_RS11945	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CRN75_RS11950	COG0726	polysaccharide deacetylase
CRN75_RS11960	COG0463	Glycosyl transferase, family 2
CRN75_RS11965	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CRN75_RS11970	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
CRN75_RS11975	COG0386	Belongs to the glutathione peroxidase family
CRN75_RS11980	COG4139	cobalamin transport
CRN75_RS11990	COG0776	regulation of translation
CRN75_RS12015	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CRN75_RS12020	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CRN75_RS12025	COG4249	Peptidase C14 caspase catalytic subunit p20
CRN75_RS12030	COG1811	Na channel or pump
CRN75_RS12065	COG0803	Belongs to the bacterial solute-binding protein 9 family
CRN75_RS12070	COG1121	(ABC) transporter
CRN75_RS12075	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CRN75_RS12080	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CRN75_RS12085	COG3001	Fructosamine kinase
CRN75_RS12090	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CRN75_RS12090	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CRN75_RS12095	COG1703	isobutyryl-CoA mutase activity
CRN75_RS12100	COG1024	Enoyl-CoA hydratase
CRN75_RS12105	COG0427	acetyl-CoA hydrolase
CRN75_RS12110	COG0583	DNA-binding transcription factor activity
CRN75_RS12120	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CRN75_RS12125	COG1917	Cupin 2, conserved barrel domain protein
CRN75_RS12130	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
CRN75_RS12135	COG1028	Short-chain dehydrogenase reductase Sdr
CRN75_RS12145	COG1175	transmembrane transport
CRN75_RS12150	COG0395	ABC-type sugar transport system, permease component
CRN75_RS12155	COG3842	ATPase activity
CRN75_RS12160	COG1653	transport
CRN75_RS12165	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CRN75_RS12170	COG1988	membrane-bound metal-dependent
CRN75_RS12175	COG1823	symporter activity
CRN75_RS12180	COG3023	N-Acetylmuramoyl-L-alanine amidase
CRN75_RS12190	COG0823	Involved in the tonB-independent uptake of proteins
CRN75_RS12195	COG2814	Major facilitator Superfamily
CRN75_RS12205	COG0501	Belongs to the peptidase M48B family
CRN75_RS12210	COG0793	Belongs to the peptidase S41A family
CRN75_RS12220	COG1956	GAF domain-containing protein
CRN75_RS12225	COG2995	paraquat-inducible protein a
CRN75_RS12230	COG3008	intermembrane lipid transfer
CRN75_RS12240	COG2814	Major facilitator Superfamily
CRN75_RS12275	COG4251	negative regulation of phosphorylation
CRN75_RS12275	COG2203	Gaf domain
CRN75_RS12275	COG3706	GGDEF domain
CRN75_RS12275	COG5001	Diguanylate cyclase
CRN75_RS12305	COG0625	glutathione transferase activity
CRN75_RS12330	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CRN75_RS12340	COG0251	oxidation-reduction process
CRN75_RS12350	COG2814	Major facilitator Superfamily
CRN75_RS12365	COG3443	Belongs to the bacterial solute-binding protein 9 family
CRN75_RS12370	COG4211	Belongs to the binding-protein-dependent transport system permease family
CRN75_RS12375	COG1129	ABC transporter
CRN75_RS12390	COG0402	S-adenosylhomocysteine deaminase activity
CRN75_RS12400	COG1228	amidohydrolase
CRN75_RS12415	COG2988	succinylglutamate desuccinylase activity
CRN75_RS12420	COG3724	N-succinylarginine dihydrolase activity
CRN75_RS12430	COG3138	arginine N-succinyltransferase
CRN75_RS12435	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CRN75_RS12440	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CRN75_RS12450	COG1294	oxidase, subunit
CRN75_RS12460	COG3850	Histidine kinase
CRN75_RS12465	COG0583	DNA-binding transcription factor activity
CRN75_RS12475	COG0387	Pfam Sodium calcium exchanger
CRN75_RS12480	COG1702	phosphate starvation-inducible protein PhoH
CRN75_RS12490	COG3658	cytochrome
CRN75_RS12495	COG1215	transferase activity, transferring glycosyl groups
CRN75_RS12500	COG0726	polysaccharide deacetylase
CRN75_RS12500	COG1649	PFAM Uncharacterised BCR, COG1649
CRN75_RS12505	COG0457	Tetratricopeptide repeat
CRN75_RS12510	COG0006	proline dipeptidase activity
CRN75_RS12515	COG4114	ferric iron reductase
CRN75_RS12520	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CRN75_RS12545	COG1136	(ABC) transporter
CRN75_RS12545	COG0577	efflux transmembrane transporter activity
CRN75_RS12555	COG1136	(ABC) transporter
CRN75_RS12555	COG0577	efflux transmembrane transporter activity
CRN75_RS12570	COG0672	)-iron permease
CRN75_RS12585	COG2066	Belongs to the glutaminase family
CRN75_RS12590	COG3290	protein histidine kinase activity
CRN75_RS12595	COG4565	transcriptional regulatory protein
CRN75_RS12600	COG3493	citrate carrier protein
CRN75_RS12620	COG0346	lactoylglutathione lyase activity
CRN75_RS12635	COG2223	nitrite transmembrane transporter activity
CRN75_RS12640	COG0561	phosphatase activity
CRN75_RS12645	COG1187	pseudouridine synthase activity
CRN75_RS12655	COG0384	phenazine biosynthesis protein PhzF
CRN75_RS12670	COG4974	Belongs to the 'phage' integrase family
CRN75_RS12750	COG4695	Portal protein
CRN75_RS12955	COG0739	heme binding
CRN75_RS12955	COG0741	lytic transglycosylase activity
CRN75_RS12955	COG1196	nuclear chromosome segregation
CRN75_RS13060	COG3772	lysozyme
CRN75_RS13125	COG0305	Participates in initiation and elongation during chromosome replication
CRN75_RS13200	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CRN75_RS13205	COG0322	excinuclease ABC activity
CRN75_RS13210	COG2197	response regulator
CRN75_RS13220	COG3136	membrane protein required for alginate biosynthesis
CRN75_RS13230	COG0840	transmembrane signaling receptor activity
CRN75_RS13235	COG0366	Alpha amylase catalytic
CRN75_RS13250	COG2226	methyltransferase
CRN75_RS13265	COG4974	Belongs to the 'phage' integrase family
CRN75_RS13335	COG4695	Portal protein
CRN75_RS13430	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
CRN75_RS13485	COG1113	amino acid transport
CRN75_RS13495	COG1881	PFAM PEBP family protein
CRN75_RS13500	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
CRN75_RS13510	COG0655	NAD(P)H dehydrogenase (quinone) activity
CRN75_RS13520	COG2822	iron ion transport
CRN75_RS13525	COG0672	)-iron permease
CRN75_RS13530	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CRN75_RS13535	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CRN75_RS13535	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CRN75_RS13535	COG0506	proline dehydrogenase activity
CRN75_RS13550	COG1126	abc transporter atp-binding protein
CRN75_RS13555	COG0765	amino acid transport
CRN75_RS13560	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CRN75_RS13565	COG2515	1-aminocyclopropane-1-carboxylate deaminase
CRN75_RS13575	COG1191	sigma factor activity
CRN75_RS13605	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CRN75_RS13610	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
CRN75_RS13625	COG1677	Flagellar hook-basal body complex protein FliE
CRN75_RS13640	COG1317	bacterial-type flagellum organization
CRN75_RS13645	COG1157	protein secretion by the type III secretion system
CRN75_RS13700	COG1256	bacterial-type flagellum assembly
CRN75_RS13735	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CRN75_RS13740	COG1558	bacterial-type flagellum-dependent cell motility
CRN75_RS13745	COG1815	bacterial-type flagellum-dependent cell motility
CRN75_RS13755	COG2747	anti-sigma28 factor FlgM
CRN75_RS13760	COG3418	PFAM FlgN family protein
CRN75_RS13770	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CRN75_RS13775	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CRN75_RS13780	COG4935	Belongs to the peptidase S8 family
CRN75_RS13780	COG1404	Belongs to the peptidase S8 family
CRN75_RS13785	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
CRN75_RS13790	COG0745	RESPONSE REGULATOR receiver
CRN75_RS13800	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CRN75_RS13805	COG0840	transmembrane signaling receptor activity
CRN75_RS13810	COG0840	transmembrane signaling receptor activity
CRN75_RS13815	COG0835	chemotaxis
CRN75_RS13820	COG0643	Histidine kinase
CRN75_RS13820	COG2198	Histidine kinase
CRN75_RS13825	COG1360	Flagellar Motor Protein
CRN75_RS13845	COG0589	response to stress
CRN75_RS13850	COG2130	NADP-dependent
CRN75_RS13860	COG1285	pathogenesis
CRN75_RS13870	COG0840	transmembrane signaling receptor activity
CRN75_RS13885	COG1609	Transcriptional regulator
CRN75_RS13890	COG3250	beta-galactosidase activity
CRN75_RS13900	COG0604	alcohol dehydrogenase
CRN75_RS13900	COG3321	synthase
CRN75_RS13900	COG1028	Short-chain dehydrogenase reductase Sdr
CRN75_RS13930	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CRN75_RS13935	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CRN75_RS13945	COG2211	Major facilitator Superfamily
CRN75_RS13950	COG1501	Belongs to the glycosyl hydrolase 31 family
CRN75_RS13975	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CRN75_RS13980	COG1349	DNA-binding transcription factor activity
CRN75_RS13990	COG2453	phosphatase
CRN75_RS13990	COG0671	phosphoesterase, PA-phosphatase related
CRN75_RS13995	COG2267	carboxylic ester hydrolase activity
CRN75_RS14005	COG4589	Belongs to the CDS family
CRN75_RS14010	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CRN75_RS14025	COG3228	Belongs to the MtfA family
CRN75_RS14035	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CRN75_RS14045	COG0386	Belongs to the glutathione peroxidase family
CRN75_RS14050	COG0583	DNA-binding transcription factor activity
CRN75_RS14060	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CRN75_RS14130	COG1609	Transcriptional regulator
CRN75_RS14135	COG1940	carbohydrate kinase activity
CRN75_RS14140	COG1447	Phosphotransferase system cellobiose-specific component IIA
CRN75_RS14145	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CRN75_RS14150	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CRN75_RS14155	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CRN75_RS14170	COG2723	6-phospho-beta-galactosidase activity
CRN75_RS14175	COG1482	cell wall glycoprotein biosynthetic process
CRN75_RS14185	COG3122	Protein conserved in bacteria
CRN75_RS14200	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CRN75_RS14215	COG0471	metal ion transport
CRN75_RS14225	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
CRN75_RS14225	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
CRN75_RS14230	COG3051	citrate lyase alpha subunit
CRN75_RS14235	COG2301	Belongs to the HpcH HpaI aldolase family
CRN75_RS14240	COG3052	prosthetic group binding
CRN75_RS14245	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
CRN75_RS14250	COG3290	protein histidine kinase activity
CRN75_RS14270	COG2271	Major facilitator Superfamily
CRN75_RS14275	COG1840	ABC-type Fe3 transport system, periplasmic component
CRN75_RS14285	COG3842	ATPase activity
CRN75_RS14300	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CRN75_RS14300	COG2205	protein histidine kinase activity
CRN75_RS14325	COG3121	Chaperone
CRN75_RS14335	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CRN75_RS14350	COG0784	Response regulator, receiver
CRN75_RS14350	COG0835	chemotaxis
CRN75_RS14355	COG1349	DNA-binding transcription factor activity
CRN75_RS14360	COG0561	phosphatase activity
CRN75_RS14375	COG0534	Mate efflux family protein
CRN75_RS14380	COG0137	argininosuccinate synthase activity
CRN75_RS14385	COG2211	Major facilitator Superfamily
CRN75_RS14390	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
CRN75_RS14400	COG0583	DNA-binding transcription factor activity
CRN75_RS14405	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CRN75_RS14425	COG1492	cobalamin metabolic process
CRN75_RS14490	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
CRN75_RS14500	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
CRN75_RS14575	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
CRN75_RS14595	COG4656	Part of a membrane complex involved in electron transport
CRN75_RS14615	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CRN75_RS14645	COG1129	ABC transporter
CRN75_RS14650	COG1172	Belongs to the binding-protein-dependent transport system permease family
CRN75_RS14660	COG2926	Belongs to the UPF0265 family
CRN75_RS14665	COG0183	Belongs to the thiolase family
CRN75_RS14670	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CRN75_RS14675	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CRN75_RS14690	COG2851	Citrate transporter
CRN75_RS14710	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CRN75_RS14730	COG2925	Exonuclease
CRN75_RS14735	COG0531	amino acid
CRN75_RS14745	COG0371	Dehydrogenase
CRN75_RS14750	COG1129	ABC transporter
CRN75_RS14755	COG1172	Belongs to the binding-protein-dependent transport system permease family
CRN75_RS14760	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CRN75_RS14765	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CRN75_RS14775	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CRN75_RS14780	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CRN75_RS14780	COG0131	Imidazoleglycerol-phosphate dehydratase
CRN75_RS14790	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CRN75_RS14800	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CRN75_RS14800	COG0140	phosphoribosyl-ATP diphosphatase activity
CRN75_RS14810	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CRN75_RS14815	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CRN75_RS14835	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
CRN75_RS14845	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CRN75_RS14870	COG1253	flavin adenine dinucleotide binding
CRN75_RS14875	COG3069	C4-dicarboxylate transmembrane transporter activity
CRN75_RS14880	COG2982	Protein involved in outer membrane biogenesis
CRN75_RS14890	COG0572	uridine kinase
CRN75_RS14895	COG0489	protein tyrosine kinase activity
CRN75_RS14900	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CRN75_RS14900	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CRN75_RS14920	COG2814	Major facilitator Superfamily
CRN75_RS14925	COG1380	Effector of murein hydrolase LrgA
CRN75_RS14930	COG1346	cytolysis
CRN75_RS14940	COG0281	malic enzyme
CRN75_RS14945	COG2949	membrane
CRN75_RS14950	COG0298	carbon dioxide binding
CRN75_RS14955	COG0375	protein maturation
CRN75_RS14960	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CRN75_RS14965	COG0651	ATP synthesis coupled electron transport
CRN75_RS14970	COG0650	Formate hydrogenlyase subunit 4
CRN75_RS14975	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CRN75_RS14980	COG4237	Hydrogenase 4 membrane
CRN75_RS14985	COG0651	ATP synthesis coupled electron transport
CRN75_RS14990	COG3261	NADH dehydrogenase
CRN75_RS14990	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
CRN75_RS14995	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CRN75_RS15000	COG3260	NADH ubiquinone oxidoreductase 20
CRN75_RS15010	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
CRN75_RS15015	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CRN75_RS15020	COG3383	formate dehydrogenase (NAD+) activity
CRN75_RS15025	COG3604	Transcriptional regulator
CRN75_RS15030	COG2116	formate transmembrane transporter activity
CRN75_RS15050	COG1609	Transcriptional regulator
CRN75_RS15055	COG2311	Membrane
CRN75_RS15060	COG0302	gtp cyclohydrolase
CRN75_RS15065	COG0477	Major facilitator Superfamily
CRN75_RS15070	COG0583	DNA-binding transcription factor activity
CRN75_RS15100	COG1136	(ABC) transporter
CRN75_RS15110	COG0477	Major facilitator Superfamily
CRN75_RS15120	COG0303	'Molybdopterin
CRN75_RS15130	COG0488	(ABC) transporter
CRN75_RS15150	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
CRN75_RS15170	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
CRN75_RS15185	COG4106	trans-aconitate 2-methyltransferase activity
CRN75_RS15190	COG0783	Belongs to the Dps family
CRN75_RS15195	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CRN75_RS15200	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CRN75_RS15205	COG0765	amino acid transport
CRN75_RS15210	COG1126	abc transporter atp-binding protein
CRN75_RS15220	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
CRN75_RS15240	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CRN75_RS15245	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CRN75_RS15265	COG0697	spore germination
CRN75_RS15285	COG1174	glycine betaine transport
CRN75_RS15290	COG1125	glycine betaine transport
CRN75_RS15295	COG1174	glycine betaine transport
CRN75_RS15300	COG1732	Glycine betaine
CRN75_RS15315	COG2897	thiosulfate sulfurtransferase activity
CRN75_RS15325	COG1122	ATPase activity
CRN75_RS15345	COG4807	Protein conserved in bacteria
CRN75_RS15360	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
CRN75_RS15370	COG2261	transglycosylase associated protein
CRN75_RS15390	COG0277	FAD linked oxidase domain protein
CRN75_RS15395	COG1686	Belongs to the peptidase S11 family
CRN75_RS15405	COG2239	Acts as a magnesium transporter
CRN75_RS15410	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CRN75_RS15415	COG0513	Belongs to the DEAD box helicase family
CRN75_RS15420	COG1309	transcriptional regulator
CRN75_RS15425	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CRN75_RS15430	COG1131	(ABC) transporter
CRN75_RS15435	COG0842	Transport permease protein
CRN75_RS15440	COG0842	Transport permease protein
CRN75_RS15445	COG0670	Belongs to the BI1 family
CRN75_RS15450	COG0314	molybdopterin synthase activity
CRN75_RS15455	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
CRN75_RS15460	COG0315	cyclic pyranopterin monophosphate synthase activity
CRN75_RS15465	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CRN75_RS15470	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CRN75_RS15475	COG4628	conserved protein (DUF2132)
CRN75_RS15480	COG0556	nucleotide-excision repair
CRN75_RS15495	COG2226	methyltransferase
CRN75_RS15500	COG0156	8-amino-7-oxononanoate synthase activity
CRN75_RS15505	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CRN75_RS15515	COG2706	6-phosphogluconolactonase activity
CRN75_RS15525	COG0561	phosphatase activity
CRN75_RS15535	COG4149	molybdate abc transporter
CRN75_RS15540	COG0725	ABC transporter, periplasmic molybdate-binding protein
CRN75_RS15550	COG2005	Transcriptional regulator
CRN75_RS15550	COG3585	molybdate ion transport
CRN75_RS15555	COG1119	ATPase activity
CRN75_RS15565	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CRN75_RS15575	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CRN75_RS15580	COG2017	converts alpha-aldose to the beta-anomer
CRN75_RS15590	COG1404	Belongs to the peptidase S8 family
CRN75_RS15605	COG0588	phosphoglycerate mutase activity
CRN75_RS15610	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CRN75_RS15615	COG1230	cation diffusion facilitator family transporter
CRN75_RS15625	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CRN75_RS15655	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
CRN75_RS15660	COG2885	chlorophyll binding
CRN75_RS15665	COG0823	Involved in the tonB-independent uptake of proteins
CRN75_RS15670	COG3064	Membrane
CRN75_RS15670	COG3064	Membrane
CRN75_RS15675	COG0848	biopolymer transport protein
CRN75_RS15680	COG0811	peptide transport
CRN75_RS15685	COG0824	Thioesterase
CRN75_RS15690	COG3790	cyd operon protein YbgE
CRN75_RS15695	COG4890	Cyd operon protein YbgT
CRN75_RS15700	COG1294	oxidase, subunit
CRN75_RS15705	COG1271	oxidase subunit
CRN75_RS15710	COG0737	Belongs to the 5'-nucleotidase family
CRN75_RS15715	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CRN75_RS15725	COG0508	dehydrogenase complex catalyzes the overall conversion of
CRN75_RS15730	COG0567	Dehydrogenase, E1 component
CRN75_RS15740	COG1053	succinate dehydrogenase
CRN75_RS15745	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
CRN75_RS15750	COG2009	succinate dehydrogenase
CRN75_RS15775	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CRN75_RS15780	COG1984	allophanate hydrolase subunit 2
CRN75_RS15785	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CRN75_RS15790	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CRN75_RS15795	COG5212	phosphodiesterase
CRN75_RS15805	COG3272	Protein of unknown function (DUF1722)
CRN75_RS15830	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
CRN75_RS15835	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
CRN75_RS15840	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
CRN75_RS15845	COG2205	protein histidine kinase activity
CRN75_RS15850	COG0745	RESPONSE REGULATOR receiver
CRN75_RS15860	COG0033	Phosphoglucomutase
CRN75_RS15865	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
CRN75_RS15870	COG0596	Alpha beta hydrolase
CRN75_RS15880	COG0840	transmembrane signaling receptor activity
CRN75_RS15890	COG0735	belongs to the Fur family
CRN75_RS15915	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CRN75_RS15920	COG1263	PTS System
CRN75_RS15920	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CRN75_RS15920	COG2190	(PTS) system
CRN75_RS15930	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CRN75_RS15935	COG1940	carbohydrate kinase activity
CRN75_RS15935	COG1846	Transcriptional regulator
CRN75_RS15940	COG0647	UMP catabolic process
CRN75_RS15945	COG0367	asparagine synthase
CRN75_RS15980	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CRN75_RS15985	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CRN75_RS15990	COG1702	phosphate starvation-inducible protein PhoH
CRN75_RS15995	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CRN75_RS16000	COG4535	Mg2 and Co2 transporter CorC
CRN75_RS16005	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CRN75_RS16025	COG0765	amino acid transport
CRN75_RS16030	COG0765	amino acid transport
CRN75_RS16035	COG1126	abc transporter atp-binding protein
CRN75_RS16045	COG2888	peptidyl-tyrosine sulfation
CRN75_RS16055	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
CRN75_RS16060	COG1466	dna polymerase III delta subunit
CRN75_RS16065	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CRN75_RS16070	COG0799	negative regulation of ribosome biogenesis
CRN75_RS16080	COG0768	penicillin binding
CRN75_RS16085	COG0772	Belongs to the SEDS family
CRN75_RS16090	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CRN75_RS16095	COG1686	Belongs to the peptidase S11 family
CRN75_RS16100	COG2921	Belongs to the UPF0250 family
CRN75_RS16105	COG0321	lipoyl(octanoyl) transferase activity
CRN75_RS16110	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CRN75_RS16115	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CRN75_RS16120	COG3706	GGDEF domain
CRN75_RS16135	COG1278	Cold shock
CRN75_RS16140	COG2197	response regulator
CRN75_RS16150	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CRN75_RS16165	COG5265	(ABC) transporter
CRN75_RS16180	COG2979	Protein of unknown function (DUF533)
CRN75_RS16210	COG3852	Histidine kinase
CRN75_RS16230	COG3121	Chaperone
CRN75_RS16235	COG3121	Chaperone
CRN75_RS16245	COG3121	Chaperone
CRN75_RS16260	COG2197	response regulator
CRN75_RS16270	COG3710	Transcriptional regulator
CRN75_RS16280	COG3064	Membrane
CRN75_RS16280	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
CRN75_RS16280	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
CRN75_RS16280	COG3210	domain, Protein
CRN75_RS16280	COG3210	domain, Protein
CRN75_RS16280	COG3064	Membrane
CRN75_RS16285	COG2831	hemolysin activation secretion protein
CRN75_RS16295	COG3188	usher protein
CRN75_RS16300	COG3121	Chaperone
CRN75_RS16310	COG3710	Transcriptional regulator
CRN75_RS16330	COG0582	viral genome integration into host DNA
CRN75_RS16370	COG2003	Belongs to the UPF0758 family
CRN75_RS16390	COG2378	regulation of single-species biofilm formation
CRN75_RS16395	COG4735	regulation of single-species biofilm formation
CRN75_RS16440	COG2831	hemolysin activation secretion protein
CRN75_RS16445	COG3210	domain, Protein
CRN75_RS16465	COG0582	viral genome integration into host DNA
CRN75_RS16475	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CRN75_RS16480	COG2501	S4 domain
CRN75_RS16485	COG0215	cysteine-tRNA ligase activity
CRN75_RS16490	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CRN75_RS16495	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CRN75_RS16500	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CRN75_RS16505	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CRN75_RS16510	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
CRN75_RS16515	COG4181	ATPase activity
CRN75_RS16520	COG2755	lipolytic protein G-D-S-L family
CRN75_RS16525	COG0300	oxidoreductase activity
CRN75_RS16530	COG3118	belongs to the thioredoxin family
CRN75_RS16535	COG0330	HflC and HflK could
CRN75_RS16540	COG1585	Membrane protein implicated in regulation of membrane protease activity
CRN75_RS16545	COG0789	Transcriptional regulator
CRN75_RS16550	COG2217	Heavy metal translocating P-type atpase
CRN75_RS16555	COG3735	TraB family
CRN75_RS16560	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CRN75_RS16565	COG0737	Belongs to the 5'-nucleotidase family
CRN75_RS16570	COG2223	nitrite transmembrane transporter activity
CRN75_RS16575	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CRN75_RS16575	COG4651	solute:proton antiporter activity
CRN75_RS16580	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CRN75_RS16600	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CRN75_RS16605	COG0438	transferase activity, transferring glycosyl groups
CRN75_RS16610	COG0438	transferase activity, transferring glycosyl groups
CRN75_RS16615	COG1215	transferase activity, transferring glycosyl groups
CRN75_RS16620	COG1215	transferase activity, transferring glycosyl groups
CRN75_RS16625	COG2244	polysaccharide biosynthetic process
CRN75_RS16630	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CRN75_RS16635	COG0563	adenylate kinase activity
CRN75_RS16640	COG0326	Molecular chaperone. Has ATPase activity
CRN75_RS16645	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CRN75_RS16650	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CRN75_RS16655	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CRN75_RS16660	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CRN75_RS16665	COG2832	Protein of unknown function (DUF454)
CRN75_RS16680	COG3264	Mechanosensitive ion channel
CRN75_RS16680	COG1196	nuclear chromosome segregation
CRN75_RS16685	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
CRN75_RS16690	COG1309	transcriptional regulator
CRN75_RS16695	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CRN75_RS16700	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CRN75_RS16710	COG3457	Alanine racemase
CRN75_RS16715	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
CRN75_RS16720	COG0254	rRNA binding
CRN75_RS16725	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CRN75_RS16730	COG0803	Belongs to the bacterial solute-binding protein 9 family
CRN75_RS16735	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CRN75_RS16740	COG1121	(ABC) transporter
CRN75_RS16765	COG0583	DNA-binding transcription factor activity
CRN75_RS16775	COG3695	enzyme binding
CRN75_RS16780	COG3126	Type III secretion system lipoprotein chaperone (YscW)
CRN75_RS16785	COG1946	Acyl-CoA thioesterase
CRN75_RS16790	COG0004	ammonium transporteR
CRN75_RS16795	COG0347	Belongs to the P(II) protein family
CRN75_RS16800	COG1132	(ABC) transporter
CRN75_RS16805	COG1132	(ABC) transporter
CRN75_RS16810	COG1522	sequence-specific DNA binding
CRN75_RS16815	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CRN75_RS16820	COG0561	phosphatase activity
CRN75_RS16825	COG4533	DNA binding
CRN75_RS16830	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CRN75_RS16835	COG0824	Thioesterase
CRN75_RS16840	COG1555	photosystem II stabilization
CRN75_RS16845	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CRN75_RS16850	COG0776	regulation of translation
CRN75_RS16855	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CRN75_RS16860	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CRN75_RS16870	COG0544	peptidyl-prolyl cis-trans isomerase activity
CRN75_RS16880	COG0271	Belongs to the BolA IbaG family
CRN75_RS16885	COG3056	Lipoprotein
CRN75_RS16890	COG2223	nitrite transmembrane transporter activity
CRN75_RS16900	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CRN75_RS16905	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CRN75_RS16910	COG1845	cytochrome c oxidase, subunit III
CRN75_RS16915	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
CRN75_RS16920	COG0109	protoheme IX farnesyltransferase activity
CRN75_RS16925	COG2814	Major facilitator Superfamily
CRN75_RS16930	COG1666	GTP binding
CRN75_RS16940	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CRN75_RS16945	COG0693	protein deglycase activity
CRN75_RS16970	COG0301	tRNA thio-modification
CRN75_RS16970	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CRN75_RS16975	COG1722	exodeoxyribonuclease VII activity
CRN75_RS16980	COG0142	geranyltranstransferase activity
CRN75_RS16985	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CRN75_RS16990	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CRN75_RS16995	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CRN75_RS17005	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CRN75_RS17010	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CRN75_RS17010	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CRN75_RS17015	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CRN75_RS17025	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CRN75_RS17030	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CRN75_RS17035	COG1862	Preprotein translocase
CRN75_RS17040	COG0343	queuine tRNA-ribosyltransferase activity
CRN75_RS17050	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
CRN75_RS17055	COG0450	alkyl hydroperoxide reductase
CRN75_RS17070	COG0366	Alpha amylase catalytic
CRN75_RS17090	COG5002	protein histidine kinase activity
CRN75_RS17095	COG0745	RESPONSE REGULATOR receiver
CRN75_RS17105	COG0420	3'-5' exonuclease activity
CRN75_RS17110	COG0419	ATPase involved in DNA repair
CRN75_RS17115	COG1940	carbohydrate kinase activity
CRN75_RS17120	COG2974	May be involved in recombination
CRN75_RS17125	COG3123	guanosine phosphorylase activity
CRN75_RS17130	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CRN75_RS17150	COG2226	methyltransferase
CRN75_RS17180	COG2188	Transcriptional regulator
CRN75_RS17185	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CRN75_RS17190	COG2313	pseudouridylate synthase activity
CRN75_RS17195	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CRN75_RS17200	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CRN75_RS17205	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CRN75_RS17215	COG1073	alpha beta
CRN75_RS17225	COG2195	Cleaves the N-terminal amino acid of tripeptides
CRN75_RS17230	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CRN75_RS17245	COG2964	Protein conserved in bacteria
CRN75_RS17250	COG1181	Belongs to the D-alanine--D-alanine ligase family
CRN75_RS17260	COG2991	Protein conserved in bacteria
CRN75_RS17265	COG1477	protein flavinylation
CRN75_RS17270	COG2871	sodium ion transport
CRN75_RS17275	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CRN75_RS17280	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CRN75_RS17285	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CRN75_RS17290	COG1805	sodium ion transport
CRN75_RS17295	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CRN75_RS17300	COG3034	peptidoglycan biosynthetic process
CRN75_RS17305	COG0121	glutamine amidotransferase
CRN75_RS17315	COG1960	acyl-CoA dehydrogenase activity
CRN75_RS17320	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
CRN75_RS17335	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
CRN75_RS17345	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
CRN75_RS17350	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
CRN75_RS17355	COG0235	Class ii aldolase
CRN75_RS17360	COG0436	Aminotransferase
CRN75_RS17375	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CRN75_RS17380	COG1126	abc transporter atp-binding protein
CRN75_RS17385	COG0765	amino acid transport
CRN75_RS17420	COG2814	Major facilitator Superfamily
CRN75_RS17425	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
CRN75_RS17435	COG1846	Transcriptional regulator
CRN75_RS17440	COG1538	Outer membrane efflux protein
CRN75_RS17445	COG1566	PFAM secretion protein HlyD family protein
CRN75_RS17450	COG2814	Major facilitator Superfamily
CRN75_RS17455	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CRN75_RS17460	COG3118	belongs to the thioredoxin family
CRN75_RS17465	COG3148	PFAM DTW domain containing protein
CRN75_RS17470	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CRN75_RS17470	COG0045	succinate-CoA ligase (ADP-forming) activity
CRN75_RS17470	COG1042	CoA-binding domain protein
CRN75_RS17475	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CRN75_RS17480	COG5544	Lipoprotein
CRN75_RS17515	COG0542	response to heat
CRN75_RS17520	COG1496	oxidoreductase activity
CRN75_RS17525	COG0564	pseudouridine synthase activity
CRN75_RS17535	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CRN75_RS17540	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CRN75_RS17550	COG1605	Chorismate mutase
CRN75_RS17550	COG0077	Prephenate dehydratase
CRN75_RS17555	COG0287	Prephenate dehydrogenase
CRN75_RS17555	COG1605	Chorismate mutase
CRN75_RS17560	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CRN75_RS17565	COG3279	Response regulator of the LytR AlgR family
CRN75_RS17570	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CRN75_RS17575	COG3137	Salt-induced outer membrane protein
CRN75_RS17580	COG0335	large ribosomal subunit rRNA binding
CRN75_RS17585	COG0336	Belongs to the RNA methyltransferase TrmD family
CRN75_RS17590	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CRN75_RS17600	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CRN75_RS17605	COG4137	Cytochrome C assembly protein
CRN75_RS17610	COG4536	flavin adenine dinucleotide binding
CRN75_RS17620	COG2918	glutathione biosynthetic process
CRN75_RS17625	COG1238	metal cluster binding
CRN75_RS17630	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CRN75_RS17655	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
CRN75_RS17660	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CRN75_RS17665	COG2137	regulation of response to DNA damage stimulus
CRN75_RS17670	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CRN75_RS17685	COG2390	Transcriptional regulator
CRN75_RS17695	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CRN75_RS17700	COG3958	Transketolase
CRN75_RS17705	COG3959	Transketolase, thiamine diphosphate binding domain
CRN75_RS17710	COG1172	Belongs to the binding-protein-dependent transport system permease family
CRN75_RS17715	COG1129	ABC transporter
CRN75_RS17725	COG1879	ABC-type sugar transport system periplasmic component
CRN75_RS17730	COG3381	protein complex oligomerization
CRN75_RS17735	COG3302	dmso reductase anchor subunit
CRN75_RS17740	COG0437	4 iron, 4 sulfur cluster binding
CRN75_RS17745	COG0243	molybdopterin cofactor binding
CRN75_RS17750	COG1454	alcohol dehydrogenase
CRN75_RS17755	COG0235	Class ii aldolase
CRN75_RS17760	COG0738	Major facilitator superfamily
CRN75_RS17770	COG1070	Carbohydrate kinase
CRN75_RS17780	COG1349	DNA-binding transcription factor activity
CRN75_RS17785	COG2197	response regulator
CRN75_RS17795	COG3706	GGDEF domain
CRN75_RS17795	COG5001	Diguanylate cyclase
CRN75_RS17795	COG4251	negative regulation of phosphorylation
CRN75_RS17795	COG2203	Gaf domain
CRN75_RS17800	COG0784	Response regulator, receiver
CRN75_RS17800	COG2205	protein histidine kinase activity
CRN75_RS17810	COG3121	Chaperone
CRN75_RS17815	COG3188	usher protein
CRN75_RS17825	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
CRN75_RS17825	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
CRN75_RS17840	COG4177	L-phenylalanine transmembrane transporter activity
CRN75_RS17845	COG1137	ATPase activity
CRN75_RS17850	COG0410	ABC transporter
CRN75_RS17905	COG3395	kinase activity
CRN75_RS17915	COG1349	DNA-binding transcription factor activity
CRN75_RS17920	COG3622	Belongs to the hyi family
CRN75_RS17925	COG3246	L-lysine catabolic process to acetate
CRN75_RS17945	COG0640	Transcriptional regulator
CRN75_RS17950	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CRN75_RS17960	COG3048	D-serine ammonia-lyase activity
CRN75_RS17965	COG2610	gluconate transmembrane transporter activity
CRN75_RS17970	COG0583	DNA-binding transcription factor activity
CRN75_RS17975	COG4608	Belongs to the ABC transporter superfamily
CRN75_RS17980	COG0444	Belongs to the ABC transporter superfamily
CRN75_RS17985	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CRN75_RS17990	COG0601	transmembrane transport
CRN75_RS17995	COG0747	negative chemotaxis
CRN75_RS18000	COG4948	Mandelate Racemase Muconate Lactonizing
CRN75_RS18005	COG1858	cytochrome C peroxidase
CRN75_RS18015	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CRN75_RS18020	COG1028	Short-chain dehydrogenase reductase Sdr
CRN75_RS18040	COG1538	Outer membrane efflux protein
CRN75_RS18045	COG0577	efflux transmembrane transporter activity
CRN75_RS18045	COG1136	(ABC) transporter
CRN75_RS18050	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CRN75_RS18080	COG3539	Fimbrial protein
CRN75_RS18085	COG3539	Fimbrial protein
CRN75_RS18100	COG3121	Chaperone
CRN75_RS18105	COG3188	usher protein
CRN75_RS18130	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CRN75_RS18135	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CRN75_RS18140	COG4942	peptidase
CRN75_RS18140	COG1388	LysM domain
CRN75_RS18145	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CRN75_RS18150	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CRN75_RS18155	COG0585	pseudouridine synthase activity
CRN75_RS18160	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CRN75_RS18170	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
CRN75_RS18180	COG0765	amino acid transport
CRN75_RS18195	COG0529	Catalyzes the synthesis of activated sulfate
CRN75_RS18200	COG2895	sulfate adenylyltransferase (ATP) activity
CRN75_RS18205	COG0175	sulfate reduction
CRN75_RS18210	COG1648	precorrin-2 dehydrogenase activity
CRN75_RS18210	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CRN75_RS18220	COG2234	aminopeptidase activity
CRN75_RS18225	COG0175	sulfate reduction
CRN75_RS18230	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CRN75_RS18235	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CRN75_RS18240	COG0720	synthase
CRN75_RS18245	COG0602	queuosine metabolic process
CRN75_RS18260	COG0504	CTP synthase activity
CRN75_RS18265	COG3956	TIGRFAM MazG family protein
CRN75_RS18270	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CRN75_RS18275	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CRN75_RS18280	COG2205	protein histidine kinase activity
CRN75_RS18280	COG3437	response regulator, receiver
CRN75_RS18280	COG4999	Histidine kinase
CRN75_RS18280	COG3850	Histidine kinase
CRN75_RS18285	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CRN75_RS18290	COG0232	Belongs to the dGTPase family. Type 2 subfamily
CRN75_RS18295	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CRN75_RS18305	COG2860	membrane
CRN75_RS18315	COG0316	Belongs to the HesB IscA family
CRN75_RS18325	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CRN75_RS18335	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CRN75_RS18340	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CRN75_RS18345	COG1120	ATPase activity
CRN75_RS18350	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CRN75_RS18355	COG1643	Atp-dependent helicase
CRN75_RS18360	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
CRN75_RS18365	COG1489	DNA binding
CRN75_RS18380	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CRN75_RS18385	COG0617	tRNA 3'-terminal CCA addition
CRN75_RS18390	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CRN75_RS18395	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CRN75_RS18400	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CRN75_RS18405	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CRN75_RS18410	COG0726	polysaccharide deacetylase
CRN75_RS18415	COG0842	Transport permease protein
CRN75_RS18420	COG1131	(ABC) transporter
CRN75_RS18425	COG0288	reversible hydration of carbon dioxide
CRN75_RS18430	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CRN75_RS18435	COG2132	Multicopper oxidase
CRN75_RS18445	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CRN75_RS18465	COG3210	domain, Protein
CRN75_RS18470	COG0697	spore germination
CRN75_RS18475	COG3112	Uncharacterised protein family (UPF0231)
CRN75_RS18480	COG1049	propionate catabolic process, 2-methylcitrate cycle
CRN75_RS18500	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CRN75_RS18505	COG0508	dehydrogenase complex catalyzes the overall conversion of
CRN75_RS18510	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CRN75_RS18515	COG2186	Transcriptional regulator
CRN75_RS18520	COG1113	amino acid transport
CRN75_RS18525	COG2211	Major facilitator Superfamily
CRN75_RS18530	COG3940	Belongs to the glycosyl hydrolase 43 family
CRN75_RS18535	COG3725	Membrane protein required for beta-lactamase induction
CRN75_RS18550	COG4969	Belongs to the N-Me-Phe pilin family
CRN75_RS18555	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CRN75_RS18560	COG1459	type II secretion system
CRN75_RS18565	COG0516	GMP reductase activity
CRN75_RS18585	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
CRN75_RS18590	COG0494	nUDIX hydrolase
CRN75_RS18595	COG0653	protein targeting
CRN75_RS18615	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CRN75_RS18620	COG0849	cell division
CRN75_RS18625	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CRN75_RS18635	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CRN75_RS18640	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CRN75_RS18645	COG0772	Belongs to the SEDS family
CRN75_RS18655	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CRN75_RS18660	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CRN75_RS18665	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CRN75_RS18670	COG0768	penicillin binding
CRN75_RS18675	COG3116	cell division
CRN75_RS18680	COG0275	rRNA processing
CRN75_RS18705	COG0028	Belongs to the TPP enzyme family
CRN75_RS18710	COG1022	Amp-dependent synthetase and ligase
CRN75_RS18720	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CRN75_RS18725	COG0473	3-isopropylmalate dehydrogenase activity
CRN75_RS18730	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CRN75_RS18745	COG3033	Beta-eliminating lyase
CRN75_RS18750	COG0814	amino acid
CRN75_RS18755	COG2814	Major facilitator Superfamily
CRN75_RS18760	COG1882	Formate acetyltransferase
CRN75_RS18765	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CRN75_RS18770	COG4533	DNA binding
CRN75_RS18775	COG4143	(ABC) transporter
CRN75_RS18780	COG1178	ABC-type Fe3 transport system permease component
CRN75_RS18785	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
CRN75_RS18790	COG0586	Pfam SNARE associated Golgi protein
CRN75_RS18795	COG0417	DNA replication proofreading
CRN75_RS18805	COG0564	pseudouridine synthase activity
CRN75_RS18815	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CRN75_RS18820	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CRN75_RS18835	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CRN75_RS18840	COG2967	ApaG domain
CRN75_RS18845	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CRN75_RS18855	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CRN75_RS18865	COG2966	Psort location CytoplasmicMembrane, score
CRN75_RS18870	COG1280	lysine exporter protein (LysE YggA)
CRN75_RS18875	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CRN75_RS18885	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CRN75_RS18890	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CRN75_RS18895	COG1047	Peptidyl-prolyl cis-trans
CRN75_RS18900	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CRN75_RS18905	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CRN75_RS18910	COG0196	riboflavin kinase activity
CRN75_RS18925	COG0583	DNA-binding transcription factor activity
CRN75_RS18930	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CRN75_RS18935	COG0484	heat shock protein binding
CRN75_RS18945	COG1584	GPR1 FUN34 yaaH family protein
CRN75_RS18960	COG0521	Mo-molybdopterin cofactor biosynthetic process
CRN75_RS18965	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CRN75_RS18975	COG3022	response to hydroperoxide
CRN75_RS19005	COG0745	RESPONSE REGULATOR receiver
CRN75_RS19010	COG3045	CreA protein
CRN75_RS19020	COG3708	Transcriptional regulator
CRN75_RS19020	COG2207	Transcriptional regulator
CRN75_RS19025	COG0406	alpha-ribazole phosphatase activity
CRN75_RS19030	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
CRN75_RS19035	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
CRN75_RS19040	COG0741	lytic transglycosylase activity
CRN75_RS19045	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CRN75_RS19055	COG2199	diguanylate cyclase activity
CRN75_RS19060	COG2885	chlorophyll binding
CRN75_RS19065	COG0488	(ABC) transporter
CRN75_RS19105	COG1454	alcohol dehydrogenase
CRN75_RS19120	COG0604	alcohol dehydrogenase
CRN75_RS19140	COG0560	Phosphoserine phosphatase
CRN75_RS19145	COG3726	membrane protein affecting hemolysin expression
CRN75_RS19155	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
CRN75_RS19160	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
CRN75_RS19170	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CRN75_RS19175	COG0084	hydrolase, TatD family'
CRN75_RS19180	COG4667	esterase of the alpha-beta hydrolase superfamily
CRN75_RS19190	COG2823	Periplasmic or secreted lipoprotein
CRN75_RS19195	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CRN75_RS19205	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
CRN75_RS19215	COG0667	Aldo Keto reductase
CRN75_RS19280	COG3284	Transcriptional regulator
CRN75_RS19295	COG0738	Major facilitator superfamily
CRN75_RS19310	COG2192	nodulation
CRN75_RS19325	COG1461	Dihydroxyacetone kinase
CRN75_RS19355	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CRN75_RS19360	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CRN75_RS19370	COG2235	arginine
CRN75_RS19385	COG0859	PFAM glycosyl transferase family 9
CRN75_RS19390	COG1070	Carbohydrate kinase
CRN75_RS19395	COG2390	Transcriptional regulator
CRN75_RS19405	COG1129	ABC transporter
CRN75_RS19410	COG1172	Belongs to the binding-protein-dependent transport system permease family
CRN75_RS19415	COG1172	Belongs to the binding-protein-dependent transport system permease family
CRN75_RS19420	COG1879	ABC-type sugar transport system periplasmic component
CRN75_RS19425	COG1830	Aldolase
CRN75_RS19430	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
CRN75_RS19465	COG0454	-acetyltransferase
CRN75_RS19470	COG2850	peptidyl-arginine hydroxylation
CRN75_RS19485	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CRN75_RS19490	COG2226	methyltransferase
CRN75_RS19495	COG0745	RESPONSE REGULATOR receiver
CRN75_RS19500	COG2205	protein histidine kinase activity
CRN75_RS19500	COG0784	Response regulator, receiver
CRN75_RS19525	COG3210	domain, Protein
CRN75_RS19560	COG0642	Histidine kinase
CRN75_RS19590	COG1401	restriction endodeoxyribonuclease activity
CRN75_RS19610	COG2003	Belongs to the UPF0758 family
CRN75_RS19625	COG3596	GTP binding
CRN75_RS19670	COG0582	viral genome integration into host DNA
CRN75_RS19680	COG0795	lipopolysaccharide-transporting ATPase activity
CRN75_RS19685	COG0795	lipopolysaccharide-transporting ATPase activity
CRN75_RS19690	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CRN75_RS19695	COG2927	DNA polymerase III (CHI subunit)
CRN75_RS19710	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
CRN75_RS19720	COG2731	YhcH YjgK YiaL family protein
CRN75_RS19730	COG0601	transmembrane transport
CRN75_RS19735	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CRN75_RS19740	COG0444	Belongs to the ABC transporter superfamily
CRN75_RS19745	COG4608	Belongs to the ABC transporter superfamily
CRN75_RS19750	COG2249	NAD(P)H dehydrogenase (quinone) activity
CRN75_RS19755	COG0583	DNA-binding transcription factor activity
CRN75_RS19765	COG0602	queuosine metabolic process
CRN75_RS19780	COG2188	Transcriptional regulator
CRN75_RS19785	COG3624	Phosphonate C-P lyase system protein PhnG
CRN75_RS19790	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
CRN75_RS19795	COG3626	phosphonate metabolism
CRN75_RS19800	COG3627	carbon phosphorus lyase activity
CRN75_RS19805	COG4107	phosphonate C-P lyase system protein PhnK
CRN75_RS19810	COG4778	phosphonate C-P lyase system protein PhnL
CRN75_RS19815	COG3454	Phosphonate metabolism
CRN75_RS19820	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
CRN75_RS19825	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CRN75_RS19830	COG0702	epimerase
CRN75_RS19835	COG3787	Belongs to the UPF0306 family
CRN75_RS19845	COG3842	ATPase activity
CRN75_RS19850	COG0395	ABC-type sugar transport system, permease component
CRN75_RS19855	COG1175	transmembrane transport
CRN75_RS19860	COG1653	transport
CRN75_RS19875	COG1982	Orn Lys Arg decarboxylase major
CRN75_RS19880	COG0531	amino acid
CRN75_RS19885	COG2827	Endonuclease containing a URI domain
CRN75_RS19890	COG3153	acetyltransferase
CRN75_RS19895	COG3154	lipid carrier protein
CRN75_RS19900	COG0826	peptidase U32
CRN75_RS19905	COG0826	peptidase U32
CRN75_RS19925	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CRN75_RS19930	COG0513	Belongs to the DEAD box helicase family
CRN75_RS19945	COG1185	polyribonucleotide nucleotidyltransferase activity
CRN75_RS19955	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CRN75_RS19960	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CRN75_RS19965	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CRN75_RS19970	COG0195	Participates in both transcription termination and antitermination
CRN75_RS19990	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CRN75_RS20000	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CRN75_RS20010	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
CRN75_RS20015	COG1534	Rna-binding protein
CRN75_RS20025	COG2027	D-alanyl-D-alanine carboxypeptidase
CRN75_RS20030	COG0745	RESPONSE REGULATOR receiver
CRN75_RS20035	COG0642	Histidine kinase
CRN75_RS20040	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CRN75_RS20045	COG0697	spore germination
CRN75_RS20060	COG0142	geranyltranstransferase activity
CRN75_RS20070	COG3423	Transcriptional regulator
CRN75_RS20095	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CRN75_RS20110	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CRN75_RS20115	COG2105	PFAM AIG2 family protein
CRN75_RS20130	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CRN75_RS20135	COG1253	flavin adenine dinucleotide binding
CRN75_RS20145	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
CRN75_RS20150	COG1218	3'(2'),5'-bisphosphate nucleotidase
CRN75_RS20155	COG0737	Belongs to the 5'-nucleotidase family
CRN75_RS20165	COG0545	Peptidyl-prolyl cis-trans isomerase
CRN75_RS20170	COG3061	Opacity-associated protein A
CRN75_RS20175	COG0359	binds to the 23S rRNA
CRN75_RS20180	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CRN75_RS20185	COG2965	DNA replication, synthesis of RNA primer
CRN75_RS20190	COG0360	Binds together with S18 to 16S ribosomal RNA
CRN75_RS20205	COG1073	alpha beta
CRN75_RS20210	COG3650	response to hydrogen peroxide
CRN75_RS20215	COG1960	acyl-CoA dehydrogenase activity
CRN75_RS20220	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CRN75_RS20225	COG0557	exoribonuclease II activity
CRN75_RS20235	COG1959	2 iron, 2 sulfur cluster binding
CRN75_RS20240	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CRN75_RS20245	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
CRN75_RS20250	COG0330	HflC and HflK could
CRN75_RS20255	COG0330	HflC and HflK could
CRN75_RS20260	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CRN75_RS20265	COG1923	regulation of RNA biosynthetic process
CRN75_RS20270	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CRN75_RS20275	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CRN75_RS20280	COG0860	N-Acetylmuramoyl-L-alanine amidase
CRN75_RS20285	COG0802	atpase or kinase
CRN75_RS20290	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CRN75_RS20290	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CRN75_RS20295	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CRN75_RS20320	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
CRN75_RS20330	COG1162	GTPase activity
CRN75_RS20335	COG0688	phosphatidylethanolamine metabolic process
CRN75_RS20340	COG1511	domain protein
CRN75_RS20340	COG3264	Mechanosensitive ion channel
CRN75_RS20345	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
CRN75_RS20350	COG1053	succinate dehydrogenase
CRN75_RS20355	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CRN75_RS20360	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
CRN75_RS20365	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
CRN75_RS20385	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CRN75_RS20390	COG1509	lysine 2,3-aminomutase activity
CRN75_RS20405	COG0459	protein refolding
CRN75_RS20410	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CRN75_RS20425	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CRN75_RS20435	COG4232	protein-disulfide reductase activity
CRN75_RS20440	COG3383	formate dehydrogenase (NAD+) activity
CRN75_RS20445	COG0493	'glutamate synthase
CRN75_RS20445	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CRN75_RS20450	COG0493	'glutamate synthase
CRN75_RS20450	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CRN75_RS20455	COG2271	Major facilitator Superfamily
CRN75_RS20460	COG2721	sulfolactate sulfo-lyase activity
CRN75_RS20465	COG3835	regulator
CRN75_RS20470	COG1929	Belongs to the glycerate kinase type-1 family
CRN75_RS20475	COG2084	Dehydrogenase
CRN75_RS20485	COG1309	transcriptional regulator
CRN75_RS20530	COG3720	iron ion transport
CRN75_RS20535	COG4558	Periplasmic binding protein
CRN75_RS20540	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CRN75_RS20545	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CRN75_RS20550	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CRN75_RS20565	COG4774	siderophore transport
CRN75_RS20570	COG1196	nuclear chromosome segregation
CRN75_RS20570	COG3264	Mechanosensitive ion channel
CRN75_RS20575	COG0425	Belongs to the sulfur carrier protein TusA family
CRN75_RS20580	COG2391	methyltransferase activity
CRN75_RS20735	COG2205	protein histidine kinase activity
CRN75_RS20735	COG5002	protein histidine kinase activity
CRN75_RS20735	COG0784	Response regulator, receiver
CRN75_RS20740	COG2197	response regulator
CRN75_RS20745	COG1301	dicarboxylic acid transport
CRN75_RS20750	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CRN75_RS20755	COG3162	membrane
CRN75_RS20760	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CRN75_RS20805	COG0138	bifunctional purine biosynthesis protein purh
CRN75_RS20810	COG0151	Belongs to the GarS family
CRN75_RS20830	COG1515	deoxyribonuclease V activity
CRN75_RS20835	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CRN75_RS20840	COG2816	NAD+ diphosphatase activity
CRN75_RS20845	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
CRN75_RS20860	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CRN75_RS20865	COG2104	thiamine diphosphate biosynthetic process
CRN75_RS20870	COG2022	thiamine diphosphate biosynthetic process
CRN75_RS20875	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CRN75_RS20880	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CRN75_RS20885	COG0085	RNA polymerase activity
CRN75_RS20900	COG0081	regulation of translation
CRN75_RS20905	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CRN75_RS20910	COG0250	Participates in transcription elongation, termination and antitermination
CRN75_RS20950	COG1072	(Pantothenic acid kinase))
CRN75_RS20955	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
CRN75_RS20955	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
CRN75_RS20995	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CRN75_RS21000	COG1739	Uncharacterized protein family UPF0029
CRN75_RS21010	COG1024	Enoyl-CoA hydratase
CRN75_RS21010	COG1250	3-hydroxyacyl-CoA dehydrogenase
CRN75_RS21015	COG0183	Belongs to the thiolase family
CRN75_RS21025	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CRN75_RS21045	COG0805	protein transport
CRN75_RS21050	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CRN75_RS21055	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CRN75_RS21060	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CRN75_RS21070	COG2226	methyltransferase
CRN75_RS21075	COG1322	Protein conserved in bacteria
CRN75_RS21080	COG0586	Pfam SNARE associated Golgi protein
CRN75_RS21085	COG1966	Carbon starvation protein
CRN75_RS21100	COG0412	Dienelactone hydrolase
CRN75_RS21105	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CRN75_RS21110	COG0583	DNA-binding transcription factor activity
CRN75_RS21115	COG0697	spore germination
CRN75_RS21120	COG0679	Auxin Efflux Carrier
CRN75_RS21125	COG0584	glycerophosphoryl diester phosphodiesterase
CRN75_RS21130	COG3842	ATPase activity
CRN75_RS21135	COG0395	ABC-type sugar transport system, permease component
CRN75_RS21140	COG1175	transmembrane transport
CRN75_RS21145	COG1653	transport
CRN75_RS21180	COG0410	ABC transporter
CRN75_RS21190	COG4177	L-phenylalanine transmembrane transporter activity
CRN75_RS21200	COG0683	leucine binding
CRN75_RS21205	COG0456	acetyltransferase
CRN75_RS21215	COG2177	Part of the ABC transporter FtsEX involved in
CRN75_RS21220	COG2884	Cell division ATP-binding protein ftsE
CRN75_RS21225	COG0552	protein localization to endoplasmic reticulum
CRN75_RS21225	COG0552	protein localization to endoplasmic reticulum
CRN75_RS21230	COG0742	ribosomal rna small subunit methyltransferase
CRN75_RS21235	COG3776	membrane
CRN75_RS21250	COG3714	YhhN family
CRN75_RS21260	COG0425	Belongs to the sulfur carrier protein TusA family
CRN75_RS21265	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
CRN75_RS21275	COG0247	lactate metabolic process
CRN75_RS21285	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CRN75_RS21290	COG2271	Major facilitator Superfamily
CRN75_RS21295	COG0584	glycerophosphoryl diester phosphodiesterase
CRN75_RS21300	COG0561	phosphatase activity
CRN75_RS21305	COG2267	carboxylic ester hydrolase activity
CRN75_RS21310	COG1280	lysine exporter protein (LysE YggA)
CRN75_RS21315	COG1280	lysine exporter protein (LysE YggA)
CRN75_RS21320	COG0514	ATP-dependent DNA helicase (RecQ)
CRN75_RS21325	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
CRN75_RS21330	COG2050	protein possibly involved in aromatic compounds catabolism
CRN75_RS21345	COG5564	TIM-barrel signal transduction protein
CRN75_RS21350	COG5441	Belongs to the UPF0261 family
CRN75_RS21360	COG0210	DNA helicase
CRN75_RS21365	COG1011	Hydrolase
CRN75_RS21370	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
CRN75_RS21375	COG3159	Protein conserved in bacteria
CRN75_RS21380	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CRN75_RS21390	COG1965	Belongs to the frataxin family
CRN75_RS21400	COG3072	Adenylate cyclase
CRN75_RS21405	COG0181	hydroxymethylbilane synthase activity
CRN75_RS21410	COG1587	Uroporphyrinogen-III synthase
CRN75_RS21415	COG2959	enzyme of heme biosynthesis
CRN75_RS21420	COG3071	HemY protein
CRN75_RS21445	COG1113	amino acid transport
CRN75_RS21460	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CRN75_RS21465	COG2244	polysaccharide biosynthetic process
CRN75_RS21470	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CRN75_RS21475	COG0456	acetyltransferase
CRN75_RS21480	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CRN75_RS21485	COG1088	dTDP-glucose 4,6-dehydratase activity
CRN75_RS21490	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CRN75_RS21495	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CRN75_RS21500	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
CRN75_RS21505	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CRN75_RS21510	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CRN75_RS21515	COG3118	belongs to the thioredoxin family
CRN75_RS21525	COG0248	Ppx GppA phosphatase
CRN75_RS21540	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CRN75_RS21550	COG3121	Chaperone
CRN75_RS21565	COG3121	Chaperone
CRN75_RS21570	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CRN75_RS21575	COG0583	DNA-binding transcription factor activity
CRN75_RS21585	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CRN75_RS21590	COG0129	dihydroxy-acid dehydratase activity
CRN75_RS21595	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CRN75_RS21600	COG3978	acetolactate synthase activity
CRN75_RS21625	COG3085	chromosome segregation
CRN75_RS21630	COG0583	DNA-binding transcription factor activity
CRN75_RS21635	COG1172	Belongs to the binding-protein-dependent transport system permease family
CRN75_RS21640	COG1172	Belongs to the binding-protein-dependent transport system permease family
CRN75_RS21645	COG1129	ABC transporter
CRN75_RS21650	COG1879	ABC-type sugar transport system periplasmic component
CRN75_RS21690	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CRN75_RS21700	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CRN75_RS21715	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CRN75_RS21725	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CRN75_RS21725	COG0678	peroxiredoxin activity
CRN75_RS21730	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CRN75_RS21760	COG1629	transport
CRN75_RS21765	COG0165	Argininosuccinate lyase
CRN75_RS21770	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CRN75_RS21785	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CRN75_RS21795	COG0460	homoserine dehydrogenase
CRN75_RS21795	COG0527	aspartate kinase activity
CRN75_RS21800	COG0626	cystathionine gamma-synthase activity
CRN75_RS21805	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
CRN75_RS21815	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CRN75_RS21820	COG1609	Transcriptional regulator
CRN75_RS21825	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CRN75_RS21830	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CRN75_RS21835	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CRN75_RS21840	COG1575	Belongs to the MenA family. Type 1 subfamily
CRN75_RS21845	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CRN75_RS21850	COG3074	FtsZ-dependent cytokinesis
CRN75_RS21865	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CRN75_RS21875	COG1494	fructose-1,6-bisphosphatase
CRN75_RS21880	COG2814	Major facilitator Superfamily
CRN75_RS21890	COG3152	Membrane
CRN75_RS21910	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
CRN75_RS21920	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CRN75_RS21925	COG3678	ATP-independent chaperone mediated protein folding
CRN75_RS21930	COG0745	RESPONSE REGULATOR receiver
CRN75_RS21935	COG2205	protein histidine kinase activity
CRN75_RS21940	COG2169	Transcriptional regulator
CRN75_RS21940	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CRN75_RS21945	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CRN75_RS21950	COG1045	serine acetyltransferase
CRN75_RS21955	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CRN75_RS21965	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CRN75_RS21970	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CRN75_RS21975	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CRN75_RS21980	COG4942	peptidase
CRN75_RS21985	COG2861	carbohydrate metabolic process
CRN75_RS21995	COG0156	8-amino-7-oxononanoate synthase activity
CRN75_RS22000	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CRN75_RS22005	COG0859	PFAM glycosyl transferase family 9
CRN75_RS22010	COG0859	PFAM glycosyl transferase family 9
CRN75_RS22015	COG1519	Transferase
CRN75_RS22025	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CRN75_RS22030	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CRN75_RS22035	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CRN75_RS22040	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CRN75_RS22045	COG2003	Belongs to the UPF0758 family
CRN75_RS22050	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CRN75_RS22055	COG0756	dUTP diphosphatase activity
CRN75_RS22060	COG1309	transcriptional regulator
CRN75_RS22065	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CRN75_RS22075	COG1561	YicC-like family, N-terminal region
CRN75_RS22090	COG1028	Short-chain dehydrogenase reductase Sdr
CRN75_RS22100	COG0583	DNA-binding transcription factor activity
CRN75_RS22105	COG0519	Catalyzes the synthesis of GMP from XMP
CRN75_RS22125	COG5001	Diguanylate cyclase
CRN75_RS22130	COG1024	Enoyl-CoA hydratase
CRN75_RS22135	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CRN75_RS22145	COG2860	membrane
CRN75_RS22150	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CRN75_RS22160	COG1758	RNA polymerase activity
CRN75_RS22165	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CRN75_RS22170	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CRN75_RS22175	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CRN75_RS22180	COG0786	glutamate:sodium symporter activity
CRN75_RS22185	COG2233	PERMEase
CRN75_RS22190	COG2982	Protein involved in outer membrane biogenesis
CRN75_RS22220	COG3423	Transcriptional regulator
CRN75_RS22225	COG0456	acetyltransferase
CRN75_RS22235	COG1295	ribonuclease BN
CRN75_RS22240	COG1011	Hydrolase
CRN75_RS22255	COG3852	Histidine kinase
CRN75_RS22265	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CRN75_RS22275	COG3078	GTPase activator activity
CRN75_RS22280	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CRN75_RS22285	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CRN75_RS22285	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CRN75_RS22290	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CRN75_RS22295	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CRN75_RS22300	COG3084	Protein conserved in bacteria
CRN75_RS22310	COG1763	Mo-molybdopterin cofactor biosynthetic process
CRN75_RS22345	COG2186	Transcriptional regulator
CRN75_RS22350	COG0477	Major facilitator Superfamily
CRN75_RS22355	COG1609	Transcriptional regulator
CRN75_RS22360	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CRN75_RS22365	COG1879	ABC-type sugar transport system periplasmic component
CRN75_RS22370	COG1172	Belongs to the binding-protein-dependent transport system permease family
CRN75_RS22380	COG1869	D-ribose catabolic process
CRN75_RS22385	COG3158	transport of potassium into the cell
CRN75_RS22390	COG0714	Associated with various cellular activities
CRN75_RS22395	COG2425	protein containing a von Willebrand factor type A (vWA) domain
CRN75_RS22410	COG1522	sequence-specific DNA binding
CRN75_RS22415	COG0716	FMN binding
CRN75_RS22425	COG0445	tRNA wobble uridine modification
CRN75_RS22430	COG0357	Ribosomal RNA small subunit methyltransferase G
CRN75_RS22435	COG3312	ion transport
CRN75_RS22440	COG0356	it plays a direct role in the translocation of protons across the membrane
CRN75_RS22450	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CRN75_RS22455	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CRN75_RS22460	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CRN75_RS22465	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CRN75_RS22470	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CRN75_RS22475	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CRN75_RS22480	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CRN75_RS22490	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CRN75_RS22495	COG0573	inorganic phosphate transmembrane transporter activity
CRN75_RS22500	COG0581	inorganic phosphate transmembrane transporter activity
CRN75_RS22510	COG0704	Plays a role in the regulation of phosphate uptake
CRN75_RS22520	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CRN75_RS22525	COG0765	amino acid transport
CRN75_RS22530	COG0765	amino acid transport
CRN75_RS22540	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CRN75_RS22545	COG2252	PERMEase
CRN75_RS22555	COG4566	intracellular signal transduction
CRN75_RS22560	COG4191	Histidine kinase
CRN75_RS22565	COG0431	NADPH-dependent FMN reductase
CRN75_RS22570	COG0840	transmembrane signaling receptor activity
CRN75_RS22575	COG2011	ABC-type metal ion transport system permease component
CRN75_RS22580	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CRN75_RS22590	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CRN75_RS22595	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CRN75_RS22600	COG0706	membrane insertase activity
CRN75_RS22610	COG0594	ribonuclease P activity
CRN75_RS22615	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CRN75_RS22625	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CRN75_RS22630	COG0592	DNA-directed DNA polymerase activity