locus-tag	class	description
CH53_RS00005	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CH53_RS00010	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CH53_RS00015	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CH53_RS00020	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CH53_RS00035	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CH53_RS00045	COG0416	fatty acid biosynthetic process
CH53_RS00050	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CH53_RS00055	COG1399	metal-binding, possibly nucleic acid-binding protein
CH53_RS00065	COG0564	pseudouridine synthase activity
CH53_RS00070	COG1530	ribonuclease E activity
CH53_RS00075	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
CH53_RS00080	COG0418	dihydroorotase activity
CH53_RS00110	COG0628	permease
CH53_RS00150	COG1560	Kdo2-lipid A biosynthetic process
CH53_RS00155	COG2259	Doxx family
CH53_RS00160	COG2814	Major facilitator Superfamily
CH53_RS00180	COG5645	(Lipo)protein
CH53_RS00185	COG2943	transferase activity, transferring hexosyl groups
CH53_RS00190	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
CH53_RS00220	COG3916	Acyl-homoserine-lactone synthase
CH53_RS00225	COG2771	luxR family
CH53_RS00235	COG0531	amino acid
CH53_RS00240	COG0076	glutamate decarboxylase activity
CH53_RS00260	COG1470	cell adhesion involved in biofilm formation
CH53_RS00260	COG1388	LysM domain
CH53_RS00285	COG0549	Belongs to the carbamate kinase family
CH53_RS00295	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CH53_RS00300	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CH53_RS00305	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
CH53_RS00310	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CH53_RS00315	COG3257	ureidoglycine aminohydrolase activity
CH53_RS00320	COG1929	Belongs to the glycerate kinase type-1 family
CH53_RS00325	COG2233	PERMEase
CH53_RS00335	COG1953	Uracil, thiamine, allantoin
CH53_RS00340	COG2084	Dehydrogenase
CH53_RS00345	COG3622	Belongs to the hyi family
CH53_RS00350	COG3960	tartronate-semialdehyde synthase activity
CH53_RS00365	COG0583	DNA-binding transcription factor activity
CH53_RS00375	COG2205	protein histidine kinase activity
CH53_RS00375	COG3437	response regulator, receiver
CH53_RS00375	COG3850	Histidine kinase
CH53_RS00375	COG4999	Histidine kinase
CH53_RS00380	COG3250	beta-galactosidase activity
CH53_RS00400	COG1215	transferase activity, transferring glycosyl groups
CH53_RS00410	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CH53_RS00415	COG1366	Belongs to the anti-sigma-factor antagonist family
CH53_RS00420	COG0745	RESPONSE REGULATOR receiver
CH53_RS00430	COG0058	SHG alpha-glucan phosphorylase activity
CH53_RS00460	COG3121	Chaperone
CH53_RS00475	COG3121	Chaperone
CH53_RS00510	COG2920	part of a sulfur-relay system
CH53_RS00515	COG1254	Belongs to the acylphosphatase family
CH53_RS00525	COG3785	DNA binding
CH53_RS00530	COG1832	CoA-binding protein
CH53_RS00545	COG0210	DNA helicase
CH53_RS00550	COG3304	Inner membrane component domain
CH53_RS00555	COG1289	transmembrane transporter activity
CH53_RS00560	COG3070	regulator of competence-specific genes
CH53_RS00565	COG5404	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
CH53_RS00575	COG3120	sequence-specific DNA binding
CH53_RS00580	COG1067	ATP-dependent peptidase activity
CH53_RS00585	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CH53_RS00595	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CH53_RS00600	COG3009	Protein conserved in bacteria
CH53_RS00605	COG3008	intermembrane lipid transfer
CH53_RS00605	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CH53_RS00610	COG2995	paraquat-inducible protein a
CH53_RS00615	COG0488	(ABC) transporter
CH53_RS00620	COG0116	Belongs to the methyltransferase superfamily
CH53_RS00620	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CH53_RS00625	COG0633	Ferredoxin
CH53_RS00625	COG3217	Mosc domain protein beta barrel domain protein
CH53_RS00635	COG0167	dihydroorotate dehydrogenase activity
CH53_RS00640	COG0308	aminopeptidase N
CH53_RS00645	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CH53_RS00650	COG0017	Asparaginyl-tRNA synthetase
CH53_RS00660	COG1448	Aminotransferase
CH53_RS00665	COG2200	EAL domain
CH53_RS00670	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CH53_RS00675	COG3108	Peptidase M15
CH53_RS00680	COG2989	Protein conserved in bacteria
CH53_RS00685	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
CH53_RS00695	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
CH53_RS00700	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CH53_RS00705	COG1434	Gram-negative-bacterium-type cell wall biogenesis
CH53_RS00710	COG3173	Aminoglycoside phosphotransferase
CH53_RS00720	COG2835	tetraacyldisaccharide 4'-kinase activity
CH53_RS00725	COG1278	Cold shock
CH53_RS00735	COG5383	Protein conserved in bacteria
CH53_RS00740	COG1663	tetraacyldisaccharide 4'-kinase activity
CH53_RS00750	COG0658	competence protein
CH53_RS00750	COG2333	competence protein COMEC
CH53_RS00755	COG0776	regulation of translation
CH53_RS00760	COG0539	negative regulation of cytoplasmic translation
CH53_RS00775	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CH53_RS00785	COG0252	asparaginase activity
CH53_RS00790	COG1944	ATP diphosphatase activity
CH53_RS00795	COG2116	formate transmembrane transporter activity
CH53_RS00800	COG1882	Formate acetyltransferase
CH53_RS00805	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CH53_RS00810	COG2814	Major facilitator Superfamily
CH53_RS00815	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CH53_RS00820	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CH53_RS00825	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
CH53_RS00830	COG3107	peptidoglycan biosynthetic process
CH53_RS00830	COG1674	ftsk spoiiie
CH53_RS00840	COG0492	ferredoxin-NADP+ reductase activity
CH53_RS00850	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
CH53_RS00860	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CH53_RS00865	COG0542	response to heat
CH53_RS00870	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CH53_RS00875	COG1278	Cold shock
CH53_RS00885	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CH53_RS00890	COG2990	Protein conserved in bacteria
CH53_RS00895	COG3593	DNA synthesis involved in DNA repair
CH53_RS00900	COG2431	L-lysine efflux transmembrane transporter activity
CH53_RS00905	COG1151	hydroxylamine reductase activity
CH53_RS00910	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CH53_RS00915	COG0028	Belongs to the TPP enzyme family
CH53_RS00925	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
CH53_RS00930	COG0702	epimerase
CH53_RS00935	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CH53_RS00945	COG1126	abc transporter atp-binding protein
CH53_RS00950	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CH53_RS00955	COG4215	(ABC) transporter
CH53_RS00960	COG4160	amino acid transport
CH53_RS00965	COG1414	Transcriptional regulator
CH53_RS00970	COG1012	belongs to the aldehyde dehydrogenase family
CH53_RS00975	COG1454	alcohol dehydrogenase
CH53_RS00980	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CH53_RS00985	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CH53_RS01000	COG1177	transmembrane transport
CH53_RS01005	COG1176	ABC-type spermidine putrescine transport system, permease component I
CH53_RS01010	COG3842	ATPase activity
CH53_RS01015	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CH53_RS01035	COG2985	domain, Protein
CH53_RS01035	COG0569	domain protein
CH53_RS01045	COG0671	phosphoesterase, PA-phosphatase related
CH53_RS01055	COG1349	DNA-binding transcription factor activity
CH53_RS01060	COG0814	amino acid
CH53_RS01065	COG1760	l-serine dehydratase
CH53_RS01070	COG1686	Belongs to the peptidase S11 family
CH53_RS01080	COG0626	cystathionine gamma-synthase activity
CH53_RS01085	COG2011	ABC-type metal ion transport system permease component
CH53_RS01110	COG0625	glutathione transferase activity
CH53_RS01115	COG4771	TonB-dependent receptor
CH53_RS01120	COG0833	amino acid
CH53_RS01125	COG0583	DNA-binding transcription factor activity
CH53_RS01135	COG2855	membrane
CH53_RS01140	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
CH53_RS01145	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
CH53_RS01145	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CH53_RS01145	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CH53_RS01150	COG1105	Belongs to the carbohydrate kinase PfkB family
CH53_RS01165	COG3005	denitrification pathway
CH53_RS01170	COG0243	molybdopterin cofactor binding
CH53_RS01175	COG1349	DNA-binding transcription factor activity
CH53_RS01185	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CH53_RS01195	COG3716	PTS system mannose fructose sorbose family IID component
CH53_RS01200	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH53_RS01205	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CH53_RS01210	COG2222	sugar isomerase
CH53_RS01235	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CH53_RS01245	COG0246	Mannitol dehydrogenase
CH53_RS01250	COG2186	Transcriptional regulator
CH53_RS01260	COG0523	cobalamin synthesis protein
CH53_RS01265	COG0671	phosphoesterase, PA-phosphatase related
CH53_RS01270	COG0791	NLP P60 protein
CH53_RS01275	COG2200	EAL domain
CH53_RS01280	COG4166	transmembrane transport
CH53_RS01285	COG4174	ABC transporter (Permease)
CH53_RS01290	COG4239	(ABC) transporter, permease
CH53_RS01295	COG4172	Belongs to the ABC transporter superfamily
CH53_RS01310	COG2814	Major facilitator Superfamily
CH53_RS01315	COG1187	pseudouridine synthase activity
CH53_RS01320	COG1061	Type III restriction enzyme res subunit
CH53_RS01330	COG3081	Nucleoid-associated protein
CH53_RS01335	COG3082	Protein of unknown function (DUF1414)
CH53_RS01355	COG3338	carbonate dehydratase activity
CH53_RS01360	COG2723	6-phospho-beta-galactosidase activity
CH53_RS01365	COG1263	PTS System
CH53_RS01365	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CH53_RS01365	COG2190	(PTS) system
CH53_RS01390	COG3299	homolog of phage Mu protein gp47
CH53_RS01430	COG4386	tail sheath protein
CH53_RS01445	COG3772	lysozyme
CH53_RS01490	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CH53_RS01505	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
CH53_RS01505	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
CH53_RS01510	COG0583	DNA-binding transcription factor activity
CH53_RS01515	COG1648	precorrin-2 dehydrogenase activity
CH53_RS01515	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CH53_RS01525	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CH53_RS01535	COG4865	methylaspartate mutase activity
CH53_RS01540	COG3799	methylaspartate ammonia-lyase activity
CH53_RS01555	COG1301	dicarboxylic acid transport
CH53_RS01570	COG3188	usher protein
CH53_RS01630	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
CH53_RS01640	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CH53_RS01640	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH53_RS01640	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH53_RS01650	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CH53_RS01655	COG2223	nitrite transmembrane transporter activity
CH53_RS01660	COG0642	Histidine kinase
CH53_RS01660	COG2198	Histidine kinase
CH53_RS01670	COG0784	Response regulator, receiver
CH53_RS01670	COG2205	protein histidine kinase activity
CH53_RS01680	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CH53_RS01685	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CH53_RS01695	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CH53_RS01700	COG4574	serine-type endopeptidase inhibitor activity
CH53_RS01730	COG0814	amino acid
CH53_RS01755	COG1441	menaquinone biosynthetic process
CH53_RS01760	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CH53_RS01770	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
CH53_RS01775	COG1169	isochorismate synthase
CH53_RS01780	COG4575	ribosome binding
CH53_RS01785	COG0129	dihydroxy-acid dehydratase activity
CH53_RS01790	COG4702	Belongs to the UPF0303 family
CH53_RS01800	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CH53_RS01805	COG1609	Transcriptional regulator
CH53_RS01810	COG1028	Short-chain dehydrogenase reductase Sdr
CH53_RS01815	COG3265	gluconokinase activity
CH53_RS01820	COG2731	YhcH YjgK YiaL family protein
CH53_RS01835	COG1007	ATP synthesis coupled electron transport
CH53_RS01840	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CH53_RS01845	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CH53_RS01850	COG0713	ATP synthesis coupled electron transport
CH53_RS01855	COG0839	Belongs to the complex I subunit 6 family
CH53_RS01860	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CH53_RS01865	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CH53_RS01870	COG1034	ATP synthesis coupled electron transport
CH53_RS01885	COG0649	NAD binding
CH53_RS01885	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CH53_RS01890	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CH53_RS01900	COG0583	DNA-binding transcription factor activity
CH53_RS01905	COG0436	Aminotransferase
CH53_RS01915	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
CH53_RS01920	COG0471	metal ion transport
CH53_RS01920	COG0490	domain, Protein
CH53_RS01925	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CH53_RS01935	COG3092	negative regulation of chromosome organization
CH53_RS01945	COG0857	belongs to the CobB CobQ family
CH53_RS01945	COG0280	phosphate acetyltransferase
CH53_RS01950	COG1609	Transcriptional regulator
CH53_RS01955	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH53_RS01965	COG3037	sugar-specific permease SgaT UlaA
CH53_RS01970	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
CH53_RS01975	COG0622	Phosphoesterase
CH53_RS01985	COG1090	epimerase
CH53_RS01990	COG4598	ABC transporter
CH53_RS02000	COG4215	(ABC) transporter
CH53_RS02005	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CH53_RS02015	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CH53_RS02020	COG1286	toxin biosynthetic process
CH53_RS02025	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
CH53_RS02030	COG0285	dihydrofolate synthase activity
CH53_RS02040	COG0586	Pfam SNARE associated Golgi protein
CH53_RS02050	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CH53_RS02075	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CH53_RS02080	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CH53_RS02105	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CH53_RS02115	COG1794	racemase activity, acting on amino acids and derivatives
CH53_RS02125	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CH53_RS02130	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
CH53_RS02130	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CH53_RS02140	COG3101	peptidyl-lysine hydroxylation
CH53_RS02145	COG0730	response to heat
CH53_RS02150	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
CH53_RS02155	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CH53_RS02160	COG2890	protein-(glutamine-N5) methyltransferase activity
CH53_RS02165	COG2840	Smr protein MutS2
CH53_RS02170	COG2062	phosphohistidine phosphatase, SixA
CH53_RS02175	COG1024	Enoyl-CoA hydratase
CH53_RS02175	COG1250	3-hydroxyacyl-CoA dehydrogenase
CH53_RS02180	COG0183	Belongs to the thiolase family
CH53_RS02185	COG3691	Protein conserved in bacteria
CH53_RS02200	COG4235	cytochrome complex assembly
CH53_RS02200	COG3088	subunit of a heme lyase
CH53_RS02205	COG3088	subunit of a heme lyase
CH53_RS02205	COG4235	cytochrome complex assembly
CH53_RS02210	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CH53_RS02215	COG1138	Cytochrome C-type biogenesis protein
CH53_RS02220	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
CH53_RS02225	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CH53_RS02230	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CH53_RS02235	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CH53_RS02250	COG2824	Alkylphosphonate utilization operon protein PhnA
CH53_RS02260	COG0582	viral genome integration into host DNA
CH53_RS02300	COG1695	Transcriptional regulator
CH53_RS02310	COG2723	6-phospho-beta-galactosidase activity
CH53_RS02315	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CH53_RS02315	COG1263	PTS System
CH53_RS02320	COG1609	Transcriptional regulator
CH53_RS02325	COG1757	Na H antiporter
CH53_RS02330	COG2353	YceI-like domain
CH53_RS02335	COG3038	cytochrome b561
CH53_RS02345	COG0626	cystathionine gamma-synthase activity
CH53_RS02365	COG1127	ABC transporter
CH53_RS02370	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CH53_RS02390	COG0531	amino acid
CH53_RS02395	COG2951	lytic endotransglycosylase activity
CH53_RS02425	COG2723	6-phospho-beta-galactosidase activity
CH53_RS02440	COG0243	molybdopterin cofactor binding
CH53_RS02445	COG0437	4 iron, 4 sulfur cluster binding
CH53_RS02450	COG3302	dmso reductase anchor subunit
CH53_RS02455	COG3381	protein complex oligomerization
CH53_RS02465	COG1598	PFAM Uncharacterised protein family UPF0150
CH53_RS02470	COG3038	cytochrome b561
CH53_RS02475	COG0436	Aminotransferase
CH53_RS02490	COG3275	phosphorelay sensor kinase activity
CH53_RS02495	COG3279	Response regulator of the LytR AlgR family
CH53_RS02500	COG2223	nitrite transmembrane transporter activity
CH53_RS02505	COG0837	glucose binding
CH53_RS02520	COG0667	Aldo Keto reductase
CH53_RS02530	COG1914	H( )-stimulated, divalent metal cation uptake system
CH53_RS02535	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CH53_RS02560	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CH53_RS02590	COG3530	Putative quorum-sensing-regulated virulence factor
CH53_RS02595	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CH53_RS02605	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
CH53_RS02615	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH53_RS02630	COG2205	protein histidine kinase activity
CH53_RS02635	COG0745	RESPONSE REGULATOR receiver
CH53_RS02640	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CH53_RS02700	COG4208	sulfate ABC transporter
CH53_RS02705	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
CH53_RS02710	COG4150	thiosulfate binding
CH53_RS02715	COG2837	iron assimilation
CH53_RS02725	COG3111	PFAM Bacterial OB fold (BOF) protein
CH53_RS02730	COG0456	acetyltransferase
CH53_RS02735	COG0408	coproporphyrinogen oxidase activity
CH53_RS02740	COG1671	Belongs to the UPF0178 family
CH53_RS02755	COG0494	nUDIX hydrolase
CH53_RS02770	COG3005	denitrification pathway
CH53_RS02775	COG3043	anaerobic respiration
CH53_RS02780	COG0243	molybdopterin cofactor binding
CH53_RS02785	COG3062	negative regulation of establishment of protein localization
CH53_RS02790	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
CH53_RS02790	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CH53_RS02795	COG2197	response regulator
CH53_RS02805	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CH53_RS02815	COG1393	Belongs to the ArsC family
CH53_RS02820	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CH53_RS02825	COG1876	peptidase activity
CH53_RS02835	COG0400	carboxylic ester hydrolase activity
CH53_RS02845	COG1444	tRNA N-acetyltransferase activity
CH53_RS02855	COG2321	neutral zinc metallopeptidase
CH53_RS02865	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
CH53_RS02870	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CH53_RS02875	COG2716	regulation of RNA biosynthetic process
CH53_RS02880	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CH53_RS02885	COG0628	permease
CH53_RS02890	COG4783	chaperone-mediated protein folding
CH53_RS02895	COG1393	Belongs to the ArsC family
CH53_RS02900	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CH53_RS02905	COG2233	PERMEase
CH53_RS02915	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CH53_RS02920	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CH53_RS02925	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CH53_RS02940	COG0581	inorganic phosphate transmembrane transporter activity
CH53_RS02945	COG0573	inorganic phosphate transmembrane transporter activity
CH53_RS02950	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CH53_RS02955	COG0248	Ppx GppA phosphatase
CH53_RS02965	COG2239	Acts as a magnesium transporter
CH53_RS02975	COG0443	Heat shock 70 kDa protein
CH53_RS02980	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CH53_RS02990	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CH53_RS02995	COG2205	protein histidine kinase activity
CH53_RS03000	COG0745	RESPONSE REGULATOR receiver
CH53_RS03005	COG3422	double-strand break repair
CH53_RS03010	COG0826	peptidase U32
CH53_RS03015	COG1597	lipid kinase activity
CH53_RS03020	COG3730	PTS system glucitol sorbitol-specific
CH53_RS03035	COG1028	Short-chain dehydrogenase reductase Sdr
CH53_RS03040	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH53_RS03045	COG1349	DNA-binding transcription factor activity
CH53_RS03065	COG0351	phosphomethylpyrimidine kinase
CH53_RS03085	COG0519	Catalyzes the synthesis of GMP from XMP
CH53_RS03085	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CH53_RS03090	COG0516	GMP reductase activity
CH53_RS03090	COG0517	IMP dehydrogenase activity
CH53_RS03100	COG1645	bacterial-type flagellum-dependent swarming motility
CH53_RS03115	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CH53_RS03120	COG2976	Protein conserved in bacteria
CH53_RS03135	COG1426	Protein conserved in bacteria
CH53_RS03145	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CH53_RS03160	COG4953	penicillin-binding protein 1C
CH53_RS03165	COG2373	Large extracellular alpha-helical protein
CH53_RS03170	COG3468	outer membrane autotransporter barrel domain protein
CH53_RS03185	COG2975	iron-sulfur cluster assembly
CH53_RS03190	COG0633	Ferredoxin
CH53_RS03195	COG0443	Heat shock 70 kDa protein
CH53_RS03200	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CH53_RS03210	COG0822	iron-sulfur transferase activity
CH53_RS03220	COG1959	2 iron, 2 sulfur cluster binding
CH53_RS03225	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
CH53_RS03235	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
CH53_RS03240	COG3683	transport system, periplasmic component
CH53_RS03245	COG3711	transcriptional antiterminator
CH53_RS03250	COG2814	Major facilitator Superfamily
CH53_RS03260	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CH53_RS03260	COG1017	nitric oxide dioxygenase activity
CH53_RS03265	COG2188	Transcriptional regulator
CH53_RS03275	COG3457	Alanine racemase
CH53_RS03280	COG1735	metal-dependent hydrolase with the TIM-barrel fold
CH53_RS03295	COG0347	Belongs to the P(II) protein family
CH53_RS03300	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CH53_RS03300	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CH53_RS03305	COG2204	response regulator
CH53_RS03310	COG3170	Tfp pilus assembly protein FimV
CH53_RS03315	COG2205	protein histidine kinase activity
CH53_RS03330	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
CH53_RS03345	COG0560	Phosphoserine phosphatase
CH53_RS03355	COG1737	Transcriptional regulator
CH53_RS03360	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CH53_RS03365	COG0736	holo-[acyl-carrier-protein] synthase activity
CH53_RS03370	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CH53_RS03375	COG1381	Involved in DNA repair and RecF pathway recombination
CH53_RS03380	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CH53_RS03395	COG0481	GTPase activity
CH53_RS03405	COG3086	response to oxidative stress
CH53_RS03410	COG3026	antisigma factor binding
CH53_RS03415	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
CH53_RS03425	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CH53_RS03430	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CH53_RS03435	COG0513	Belongs to the DEAD box helicase family
CH53_RS03450	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
CH53_RS03455	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CH53_RS03460	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CH53_RS03465	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CH53_RS03470	COG0497	DNA recombination
CH53_RS03475	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CH53_RS03485	COG2867	negative regulation of translational initiation
CH53_RS03490	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CH53_RS03540	COG3394	polysaccharide catabolic process
CH53_RS03545	COG2169	Transcriptional regulator
CH53_RS03545	COG1917	Cupin 2, conserved barrel domain protein
CH53_RS03550	COG1447	Phosphotransferase system cellobiose-specific component IIA
CH53_RS03555	COG2723	6-phospho-beta-galactosidase activity
CH53_RS03560	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CH53_RS03565	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CH53_RS03570	COG2133	pyrroloquinoline quinone binding
CH53_RS03575	COG0667	Aldo Keto reductase
CH53_RS03590	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CH53_RS03600	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
CH53_RS03605	COG4413	Urea transporter
CH53_RS03615	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CH53_RS03620	COG0830	nickel cation binding
CH53_RS03625	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
CH53_RS03630	COG0804	urea catabolic process
CH53_RS03640	COG0831	urea catabolic process
CH53_RS03645	COG1124	(ABC) transporter
CH53_RS03655	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CH53_RS03660	COG0601	transmembrane transport
CH53_RS03690	COG1278	Cold shock
CH53_RS03710	COG3708	Transcriptional regulator
CH53_RS03710	COG2207	Transcriptional regulator
CH53_RS03725	COG4575	ribosome binding
CH53_RS03735	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CH53_RS03740	COG1780	Probably involved in ribonucleotide reductase function
CH53_RS03750	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CH53_RS03760	COG4176	ABC-type proline glycine betaine transport system permease component
CH53_RS03765	COG2113	Glycine betaine
CH53_RS03805	COG2226	methyltransferase
CH53_RS03810	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CH53_RS03815	COG1388	LysM domain
CH53_RS03815	COG0741	lytic transglycosylase activity
CH53_RS03820	COG3021	interspecies interaction between organisms
CH53_RS03825	COG2814	Major facilitator Superfamily
CH53_RS03830	COG0583	DNA-binding transcription factor activity
CH53_RS03845	COG1028	Short-chain dehydrogenase reductase Sdr
CH53_RS03885	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CH53_RS03900	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CH53_RS03955	COG0542	response to heat
CH53_RS03965	COG0564	pseudouridine synthase activity
CH53_RS03970	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CH53_RS03975	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CH53_RS03980	COG0077	Prephenate dehydratase
CH53_RS03980	COG1605	Chorismate mutase
CH53_RS03985	COG0287	Prephenate dehydrogenase
CH53_RS03985	COG1605	Chorismate mutase
CH53_RS03990	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CH53_RS03995	COG3279	Response regulator of the LytR AlgR family
CH53_RS04000	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CH53_RS04005	COG3137	Salt-induced outer membrane protein
CH53_RS04010	COG0335	large ribosomal subunit rRNA binding
CH53_RS04015	COG0336	Belongs to the RNA methyltransferase TrmD family
CH53_RS04025	COG0228	four-way junction DNA binding
CH53_RS04030	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CH53_RS04035	COG4137	Cytochrome C assembly protein
CH53_RS04040	COG4536	flavin adenine dinucleotide binding
CH53_RS04045	COG1854	S-ribosylhomocysteine lyase activity
CH53_RS04050	COG2918	glutathione biosynthetic process
CH53_RS04055	COG1238	metal cluster binding
CH53_RS04060	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CH53_RS04085	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
CH53_RS04090	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CH53_RS04095	COG2137	regulation of response to DNA damage stimulus
CH53_RS04100	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CH53_RS04125	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CH53_RS04130	COG3958	Transketolase
CH53_RS04135	COG3959	Transketolase, thiamine diphosphate binding domain
CH53_RS04140	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH53_RS04145	COG1129	ABC transporter
CH53_RS04155	COG1879	ABC-type sugar transport system periplasmic component
CH53_RS04165	COG3381	protein complex oligomerization
CH53_RS04170	COG3302	dmso reductase anchor subunit
CH53_RS04175	COG0437	4 iron, 4 sulfur cluster binding
CH53_RS04180	COG0243	molybdopterin cofactor binding
CH53_RS04185	COG1454	alcohol dehydrogenase
CH53_RS04190	COG0235	Class ii aldolase
CH53_RS04195	COG0738	Major facilitator superfamily
CH53_RS04205	COG1070	Carbohydrate kinase
CH53_RS04215	COG1349	DNA-binding transcription factor activity
CH53_RS04220	COG0235	Class ii aldolase
CH53_RS04225	COG1349	DNA-binding transcription factor activity
CH53_RS04240	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH53_RS04245	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH53_RS04250	COG3623	hexulose-6-phosphate isomerase
CH53_RS04255	COG1070	Carbohydrate kinase
CH53_RS04260	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
CH53_RS04260	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
CH53_RS04275	COG4177	L-phenylalanine transmembrane transporter activity
CH53_RS04280	COG1137	ATPase activity
CH53_RS04285	COG0410	ABC transporter
CH53_RS04340	COG0640	Transcriptional regulator
CH53_RS04345	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CH53_RS04350	COG3158	transport of potassium into the cell
CH53_RS04355	COG3048	D-serine ammonia-lyase activity
CH53_RS04360	COG2610	gluconate transmembrane transporter activity
CH53_RS04365	COG0583	DNA-binding transcription factor activity
CH53_RS04370	COG4608	Belongs to the ABC transporter superfamily
CH53_RS04375	COG0444	Belongs to the ABC transporter superfamily
CH53_RS04380	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CH53_RS04385	COG0601	transmembrane transport
CH53_RS04390	COG0747	negative chemotaxis
CH53_RS04395	COG4948	Mandelate Racemase Muconate Lactonizing
CH53_RS04400	COG1028	Short-chain dehydrogenase reductase Sdr
CH53_RS04420	COG1538	Outer membrane efflux protein
CH53_RS04425	COG1136	(ABC) transporter
CH53_RS04425	COG0577	efflux transmembrane transporter activity
CH53_RS04430	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CH53_RS04445	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CH53_RS04460	COG3539	Fimbrial protein
CH53_RS04465	COG3539	Fimbrial protein
CH53_RS04480	COG3121	Chaperone
CH53_RS04485	COG3188	usher protein
CH53_RS04570	COG0084	hydrolase, TatD family'
CH53_RS04595	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CH53_RS04600	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CH53_RS04605	COG1388	LysM domain
CH53_RS04605	COG4942	peptidase
CH53_RS04610	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CH53_RS04615	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CH53_RS04620	COG0585	pseudouridine synthase activity
CH53_RS04625	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CH53_RS04635	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
CH53_RS04645	COG0765	amino acid transport
CH53_RS04660	COG0529	Catalyzes the synthesis of activated sulfate
CH53_RS04665	COG2895	sulfate adenylyltransferase (ATP) activity
CH53_RS04670	COG0175	sulfate reduction
CH53_RS04675	COG1648	precorrin-2 dehydrogenase activity
CH53_RS04675	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CH53_RS04680	COG2234	aminopeptidase activity
CH53_RS04695	COG0175	sulfate reduction
CH53_RS04700	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CH53_RS04705	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CH53_RS04710	COG0720	synthase
CH53_RS04715	COG0602	queuosine metabolic process
CH53_RS04725	COG0148	phosphopyruvate hydratase activity
CH53_RS04730	COG0504	CTP synthase activity
CH53_RS04735	COG3956	TIGRFAM MazG family protein
CH53_RS04740	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CH53_RS04745	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CH53_RS04755	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CH53_RS04760	COG0232	Belongs to the dGTPase family. Type 2 subfamily
CH53_RS04765	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CH53_RS04775	COG2860	membrane
CH53_RS04780	COG0316	Belongs to the HesB IscA family
CH53_RS04790	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CH53_RS04795	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CH53_RS04800	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CH53_RS04805	COG1120	ATPase activity
CH53_RS04810	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CH53_RS04815	COG1643	Atp-dependent helicase
CH53_RS04820	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
CH53_RS04825	COG1489	DNA binding
CH53_RS04840	COG0617	tRNA 3'-terminal CCA addition
CH53_RS04845	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CH53_RS04850	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CH53_RS04855	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CH53_RS04865	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CH53_RS04870	COG0726	polysaccharide deacetylase
CH53_RS04875	COG0842	Transport permease protein
CH53_RS04880	COG1131	(ABC) transporter
CH53_RS04885	COG0288	reversible hydration of carbon dioxide
CH53_RS04890	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CH53_RS04895	COG2132	Multicopper oxidase
CH53_RS04905	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CH53_RS04910	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
CH53_RS04920	COG3112	Uncharacterised protein family (UPF0231)
CH53_RS04925	COG1049	propionate catabolic process, 2-methylcitrate cycle
CH53_RS04940	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CH53_RS04945	COG0508	dehydrogenase complex catalyzes the overall conversion of
CH53_RS04950	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CH53_RS04955	COG2186	Transcriptional regulator
CH53_RS04960	COG1113	amino acid transport
CH53_RS04965	COG3725	Membrane protein required for beta-lactamase induction
CH53_RS04980	COG4969	Belongs to the N-Me-Phe pilin family
CH53_RS04985	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CH53_RS04990	COG1459	type II secretion system
CH53_RS04995	COG0516	GMP reductase activity
CH53_RS05010	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
CH53_RS05015	COG0494	nUDIX hydrolase
CH53_RS05020	COG0653	protein targeting
CH53_RS05040	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CH53_RS05045	COG0849	cell division
CH53_RS05050	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CH53_RS05060	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CH53_RS05065	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CH53_RS05070	COG0772	Belongs to the SEDS family
CH53_RS05080	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CH53_RS05085	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CH53_RS05090	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CH53_RS05095	COG0768	penicillin binding
CH53_RS05100	COG3116	cell division
CH53_RS05105	COG0275	rRNA processing
CH53_RS05130	COG0028	Belongs to the TPP enzyme family
CH53_RS05135	COG1022	Amp-dependent synthetase and ligase
CH53_RS05140	COG0583	DNA-binding transcription factor activity
CH53_RS05145	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CH53_RS05150	COG0473	3-isopropylmalate dehydrogenase activity
CH53_RS05155	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CH53_RS05165	COG3033	Beta-eliminating lyase
CH53_RS05170	COG0814	amino acid
CH53_RS05175	COG2814	Major facilitator Superfamily
CH53_RS05180	COG1882	Formate acetyltransferase
CH53_RS05185	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CH53_RS05190	COG4533	DNA binding
CH53_RS05195	COG4143	(ABC) transporter
CH53_RS05200	COG1178	ABC-type Fe3 transport system permease component
CH53_RS05205	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
CH53_RS05210	COG0586	Pfam SNARE associated Golgi protein
CH53_RS05220	COG0417	DNA replication proofreading
CH53_RS05225	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CH53_RS05230	COG0564	pseudouridine synthase activity
CH53_RS05235	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CH53_RS05240	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CH53_RS05255	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CH53_RS05260	COG2967	ApaG domain
CH53_RS05265	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CH53_RS05270	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CH53_RS05280	COG2966	Psort location CytoplasmicMembrane, score
CH53_RS05285	COG1280	lysine exporter protein (LysE YggA)
CH53_RS05290	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CH53_RS05305	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CH53_RS05310	COG1047	Peptidyl-prolyl cis-trans
CH53_RS05315	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CH53_RS05320	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CH53_RS05325	COG0196	riboflavin kinase activity
CH53_RS05335	COG0583	DNA-binding transcription factor activity
CH53_RS05340	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CH53_RS05345	COG0484	heat shock protein binding
CH53_RS05355	COG1584	GPR1 FUN34 yaaH family protein
CH53_RS05370	COG0521	Mo-molybdopterin cofactor biosynthetic process
CH53_RS05375	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CH53_RS05380	COG3022	response to hydroperoxide
CH53_RS05390	COG0083	homoserine kinase activity
CH53_RS05405	COG0745	RESPONSE REGULATOR receiver
CH53_RS05410	COG3045	CreA protein
CH53_RS05415	COG2207	Transcriptional regulator
CH53_RS05415	COG3708	Transcriptional regulator
CH53_RS05425	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
CH53_RS05430	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
CH53_RS05435	COG0741	lytic transglycosylase activity
CH53_RS05440	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CH53_RS05450	COG2199	diguanylate cyclase activity
CH53_RS05455	COG2885	chlorophyll binding
CH53_RS05460	COG0488	(ABC) transporter
CH53_RS05495	COG1454	alcohol dehydrogenase
CH53_RS05510	COG0604	alcohol dehydrogenase
CH53_RS05525	COG0560	Phosphoserine phosphatase
CH53_RS05530	COG3726	membrane protein affecting hemolysin expression
CH53_RS05535	COG3550	peptidyl-serine autophosphorylation
CH53_RS05545	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
CH53_RS05550	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
CH53_RS05560	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CH53_RS05565	COG0084	hydrolase, TatD family'
CH53_RS05570	COG4667	esterase of the alpha-beta hydrolase superfamily
CH53_RS05575	COG2823	Periplasmic or secreted lipoprotein
CH53_RS05580	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CH53_RS05585	COG0456	acetyltransferase
CH53_RS05590	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
CH53_RS05600	COG0667	Aldo Keto reductase
CH53_RS05690	COG2192	nodulation
CH53_RS05700	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CH53_RS05700	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH53_RS05700	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
CH53_RS05705	COG1461	Dihydroxyacetone kinase
CH53_RS05710	COG2376	Dihydroxyacetone kinase
CH53_RS05720	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CH53_RS05725	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CH53_RS05730	COG2235	arginine
CH53_RS05745	COG0859	PFAM glycosyl transferase family 9
CH53_RS05750	COG1070	Carbohydrate kinase
CH53_RS05755	COG2390	Transcriptional regulator
CH53_RS05760	COG1129	ABC transporter
CH53_RS05765	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH53_RS05770	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH53_RS05775	COG1879	ABC-type sugar transport system periplasmic component
CH53_RS05780	COG1830	Aldolase
CH53_RS05790	COG0642	Histidine kinase
CH53_RS05815	COG3272	Protein of unknown function (DUF1722)
CH53_RS05835	COG3423	Transcriptional regulator
CH53_RS05840	COG2249	NAD(P)H dehydrogenase (quinone) activity
CH53_RS05865	COG2831	hemolysin activation secretion protein
CH53_RS05870	COG3210	domain, Protein
CH53_RS05960	COG3121	Chaperone
CH53_RS05965	COG3188	usher protein
CH53_RS05985	COG1388	LysM domain
CH53_RS05985	COG1470	cell adhesion involved in biofilm formation
CH53_RS06080	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CH53_RS06115	COG0582	viral genome integration into host DNA
CH53_RS06125	COG0795	lipopolysaccharide-transporting ATPase activity
CH53_RS06130	COG0795	lipopolysaccharide-transporting ATPase activity
CH53_RS06135	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CH53_RS06140	COG2927	DNA polymerase III (CHI subunit)
CH53_RS06155	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
CH53_RS06165	COG2731	YhcH YjgK YiaL family protein
CH53_RS06175	COG0601	transmembrane transport
CH53_RS06180	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CH53_RS06185	COG0444	Belongs to the ABC transporter superfamily
CH53_RS06190	COG4608	Belongs to the ABC transporter superfamily
CH53_RS06195	COG2249	NAD(P)H dehydrogenase (quinone) activity
CH53_RS06200	COG0583	DNA-binding transcription factor activity
CH53_RS06215	COG2188	Transcriptional regulator
CH53_RS06220	COG3624	Phosphonate C-P lyase system protein PhnG
CH53_RS06225	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
CH53_RS06230	COG3626	phosphonate metabolism
CH53_RS06235	COG3627	carbon phosphorus lyase activity
CH53_RS06240	COG4107	phosphonate C-P lyase system protein PhnK
CH53_RS06245	COG4778	phosphonate C-P lyase system protein PhnL
CH53_RS06250	COG3454	Phosphonate metabolism
CH53_RS06255	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
CH53_RS06260	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CH53_RS06265	COG0702	epimerase
CH53_RS06270	COG3787	Belongs to the UPF0306 family
CH53_RS06275	COG1982	Orn Lys Arg decarboxylase major
CH53_RS06280	COG0531	amino acid
CH53_RS06285	COG2827	Endonuclease containing a URI domain
CH53_RS06290	COG3153	acetyltransferase
CH53_RS06295	COG3154	lipid carrier protein
CH53_RS06300	COG0826	peptidase U32
CH53_RS06305	COG0826	peptidase U32
CH53_RS06310	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CH53_RS06315	COG0513	Belongs to the DEAD box helicase family
CH53_RS06325	COG1185	polyribonucleotide nucleotidyltransferase activity
CH53_RS06335	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CH53_RS06340	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CH53_RS06350	COG0195	Participates in both transcription termination and antitermination
CH53_RS06370	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CH53_RS06380	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CH53_RS06390	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
CH53_RS06395	COG1534	Rna-binding protein
CH53_RS06405	COG2027	D-alanyl-D-alanine carboxypeptidase
CH53_RS06410	COG0745	RESPONSE REGULATOR receiver
CH53_RS06415	COG0642	Histidine kinase
CH53_RS06420	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CH53_RS06425	COG0697	spore germination
CH53_RS06440	COG0142	geranyltranstransferase activity
CH53_RS06455	COG3423	Transcriptional regulator
CH53_RS06480	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CH53_RS06485	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
CH53_RS06490	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CH53_RS06495	COG2105	PFAM AIG2 family protein
CH53_RS06500	COG2911	Protein conserved in bacteria
CH53_RS06505	COG0729	surface antigen
CH53_RS06510	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CH53_RS06515	COG1253	flavin adenine dinucleotide binding
CH53_RS06525	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
CH53_RS06530	COG1218	3'(2'),5'-bisphosphate nucleotidase
CH53_RS06535	COG0737	Belongs to the 5'-nucleotidase family
CH53_RS06545	COG0545	Peptidyl-prolyl cis-trans isomerase
CH53_RS06550	COG3061	Opacity-associated protein A
CH53_RS06560	COG0359	binds to the 23S rRNA
CH53_RS06565	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CH53_RS06570	COG2965	DNA replication, synthesis of RNA primer
CH53_RS06575	COG0360	Binds together with S18 to 16S ribosomal RNA
CH53_RS06585	COG1073	alpha beta
CH53_RS06590	COG3650	response to hydrogen peroxide
CH53_RS06595	COG1960	acyl-CoA dehydrogenase activity
CH53_RS06600	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CH53_RS06605	COG0557	exoribonuclease II activity
CH53_RS06610	COG1959	2 iron, 2 sulfur cluster binding
CH53_RS06615	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CH53_RS06620	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
CH53_RS06625	COG0330	HflC and HflK could
CH53_RS06630	COG0330	HflC and HflK could
CH53_RS06635	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CH53_RS06645	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CH53_RS06650	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CH53_RS06655	COG0860	N-Acetylmuramoyl-L-alanine amidase
CH53_RS06660	COG0802	atpase or kinase
CH53_RS06665	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CH53_RS06665	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CH53_RS06670	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CH53_RS06695	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
CH53_RS06700	COG1162	GTPase activity
CH53_RS06705	COG0688	phosphatidylethanolamine metabolic process
CH53_RS06710	COG1511	domain protein
CH53_RS06710	COG3264	Mechanosensitive ion channel
CH53_RS06715	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
CH53_RS06720	COG1053	succinate dehydrogenase
CH53_RS06725	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CH53_RS06730	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
CH53_RS06735	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
CH53_RS06770	COG0459	protein refolding
CH53_RS06775	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CH53_RS06790	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CH53_RS06800	COG4232	protein-disulfide reductase activity
CH53_RS06805	COG3383	formate dehydrogenase (NAD+) activity
CH53_RS06810	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CH53_RS06815	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CH53_RS06815	COG0493	'glutamate synthase
CH53_RS06820	COG2271	Major facilitator Superfamily
CH53_RS06825	COG2721	sulfolactate sulfo-lyase activity
CH53_RS06830	COG3835	regulator
CH53_RS06835	COG1929	Belongs to the glycerate kinase type-1 family
CH53_RS06840	COG2084	Dehydrogenase
CH53_RS06850	COG1309	transcriptional regulator
CH53_RS06860	COG3876	Protein conserved in bacteria
CH53_RS06870	COG1472	Belongs to the glycosyl hydrolase 3 family
CH53_RS06880	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CH53_RS06885	COG1263	PTS System
CH53_RS06885	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CH53_RS06895	COG0840	transmembrane signaling receptor activity
CH53_RS06900	COG1882	Formate acetyltransferase
CH53_RS06905	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CH53_RS06910	COG0814	amino acid
CH53_RS06920	COG0488	(ABC) transporter
CH53_RS06935	COG3720	iron ion transport
CH53_RS06940	COG4558	Periplasmic binding protein
CH53_RS06945	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CH53_RS06950	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CH53_RS06955	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CH53_RS06965	COG4774	siderophore transport
CH53_RS06970	COG1511	domain protein
CH53_RS06970	COG3264	Mechanosensitive ion channel
CH53_RS07135	COG1301	dicarboxylic acid transport
CH53_RS07140	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CH53_RS07145	COG3162	membrane
CH53_RS07150	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CH53_RS07180	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CH53_RS07185	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CH53_RS07190	COG0009	L-threonylcarbamoyladenylate synthase
CH53_RS07195	COG0551	DNA topoisomerase type I activity
CH53_RS07205	COG0758	DNA mediated transformation
CH53_RS07210	COG0242	peptide deformylase activity
CH53_RS07215	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CH53_RS07220	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CH53_RS07220	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CH53_RS07225	COG0569	domain protein
CH53_RS07230	COG1970	mechanosensitive ion channel activity
CH53_RS07235	COG3036	rescue of stalled ribosome
CH53_RS07240	COG0789	Transcriptional regulator
CH53_RS07250	COG0203	ribosomal protein L17
CH53_RS07260	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CH53_RS07265	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CH53_RS07270	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CH53_RS07275	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CH53_RS07280	COG0201	protein transport
CH53_RS07285	COG0200	Binds to the 23S rRNA
CH53_RS07290	COG1841	ribosomal large subunit assembly
CH53_RS07295	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CH53_RS07300	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CH53_RS07305	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CH53_RS07310	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CH53_RS07315	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CH53_RS07325	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CH53_RS07330	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CH53_RS07335	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CH53_RS07340	COG0255	Belongs to the universal ribosomal protein uL29 family
CH53_RS07345	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CH53_RS07350	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CH53_RS07360	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CH53_RS07370	COG0089	rRNA binding
CH53_RS07385	COG0051	transcription antitermination factor activity, RNA binding
CH53_RS07400	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CH53_RS07410	COG0049	tRNA binding
CH53_RS07415	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CH53_RS07420	COG2168	tRNA wobble position uridine thiolation
CH53_RS07425	COG2923	Belongs to the DsrF TusC family
CH53_RS07430	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
CH53_RS07435	COG2964	Protein conserved in bacteria
CH53_RS07440	COG0545	Peptidyl-prolyl cis-trans isomerase
CH53_RS07450	COG1047	Peptidyl-prolyl cis-trans
CH53_RS07455	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
CH53_RS07465	COG2249	NAD(P)H dehydrogenase (quinone) activity
CH53_RS07470	COG0488	(ABC) transporter
CH53_RS07475	COG1216	Glycosyl transferase, family 2
CH53_RS07485	COG2175	clavaminate synthase activity
CH53_RS07490	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CH53_RS07500	COG4521	taurine ABC transporter
CH53_RS07515	COG0429	hydrolase of the alpha beta-hydrolase fold
CH53_RS07525	COG3954	Phosphoribulokinase
CH53_RS07530	COG1765	OsmC-like protein
CH53_RS07540	COG1289	transmembrane transporter activity
CH53_RS07565	COG0433	COG0433 Predicted ATPase
CH53_RS07570	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CH53_RS07580	COG1486	melibiose metabolic process
CH53_RS07600	COG0738	Major facilitator superfamily
CH53_RS07605	COG0402	S-adenosylhomocysteine deaminase activity
CH53_RS07610	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CH53_RS07625	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CH53_RS07625	COG1648	precorrin-2 dehydrogenase activity
CH53_RS07630	COG0180	Tryptophanyl-tRNA synthetase
CH53_RS07640	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CH53_RS07660	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CH53_RS07665	COG4796	Type ii and iii secretion system protein
CH53_RS07690	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CH53_RS07695	COG0494	nUDIX hydrolase
CH53_RS07705	COG1011	Hydrolase
CH53_RS07710	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CH53_RS07740	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CH53_RS07745	COG2183	response to ionizing radiation
CH53_RS07750	COG1918	ferrous iron import across plasma membrane
CH53_RS07770	COG0596	Alpha beta hydrolase
CH53_RS07780	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CH53_RS07780	COG0316	Belongs to the HesB IscA family
CH53_RS07785	COG1640	4-alpha-glucanotransferase
CH53_RS07790	COG0058	SHG alpha-glucan phosphorylase activity
CH53_RS07795	COG2909	trisaccharide binding
CH53_RS07805	COG0705	Rhomboid family
CH53_RS07810	COG1349	DNA-binding transcription factor activity
CH53_RS07815	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CH53_RS07820	COG0058	SHG alpha-glucan phosphorylase activity
CH53_RS07825	COG0297	glycogen (starch) synthase activity
CH53_RS07830	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CH53_RS07835	COG1523	belongs to the glycosyl hydrolase 13 family
CH53_RS07840	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CH53_RS07845	COG3275	phosphorelay sensor kinase activity
CH53_RS07865	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CH53_RS07870	COG2095	MarC family integral membrane protein
CH53_RS07875	COG3265	gluconokinase activity
CH53_RS07880	COG2610	gluconate transmembrane transporter activity
CH53_RS07885	COG1609	Transcriptional regulator
CH53_RS07890	COG1741	Belongs to the pirin family
CH53_RS07895	COG1247	-acetyltransferase
CH53_RS07900	COG1082	Xylose isomerase domain protein TIM barrel
CH53_RS07905	COG0673	inositol 2-dehydrogenase activity
CH53_RS07910	COG3962	Belongs to the TPP enzyme family
CH53_RS07925	COG3718	enzyme involved in inositol metabolism
CH53_RS07940	COG2814	Major facilitator Superfamily
CH53_RS07945	COG0583	DNA-binding transcription factor activity
CH53_RS07960	COG2081	HI0933 family
CH53_RS07965	COG0306	phosphate transporter
CH53_RS07975	COG0589	response to stress
CH53_RS07985	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
CH53_RS07990	COG0742	ribosomal rna small subunit methyltransferase
CH53_RS08000	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
CH53_RS08005	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CH53_RS08015	COG1396	sequence-specific DNA binding
CH53_RS08020	COG1295	ribonuclease BN
CH53_RS08025	COG2134	cdp-diacylglycerol pyrophosphatase
CH53_RS08030	COG2982	Protein involved in outer membrane biogenesis
CH53_RS08035	COG2200	EAL domain
CH53_RS08040	COG1942	4-Oxalocrotonate Tautomerase
CH53_RS08045	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CH53_RS08050	COG0612	Peptidase, M16
CH53_RS08055	COG1301	dicarboxylic acid transport
CH53_RS08070	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CH53_RS08080	COG3188	usher protein
CH53_RS08085	COG3121	Chaperone
CH53_RS08095	COG2199	diguanylate cyclase activity
CH53_RS08095	COG2200	EAL domain
CH53_RS08100	COG3118	belongs to the thioredoxin family
CH53_RS08100	COG0457	Tetratricopeptide repeat
CH53_RS08105	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
CH53_RS08110	COG1215	transferase activity, transferring glycosyl groups
CH53_RS08120	COG1192	Involved in chromosome partitioning
CH53_RS08140	COG2194	sulfuric ester hydrolase activity
CH53_RS08145	COG4608	Belongs to the ABC transporter superfamily
CH53_RS08150	COG0444	Belongs to the ABC transporter superfamily
CH53_RS08155	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CH53_RS08160	COG0601	transmembrane transport
CH53_RS08165	COG0747	negative chemotaxis
CH53_RS08180	COG2271	Major facilitator Superfamily
CH53_RS08185	COG3851	Histidine kinase
CH53_RS08190	COG2197	response regulator
CH53_RS08195	COG2194	sulfuric ester hydrolase activity
CH53_RS08200	COG1764	response to oxidative stress
CH53_RS08220	COG2986	histidine ammonia-lyase
CH53_RS08225	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
CH53_RS08235	COG2207	Transcriptional regulator
CH53_RS08235	COG1609	Transcriptional regulator
CH53_RS08240	COG4214	carbohydrate transport
CH53_RS08250	COG4213	ABC transporter substrate-binding protein
CH53_RS08255	COG2115	Belongs to the xylose isomerase family
CH53_RS08260	COG1070	Carbohydrate kinase
CH53_RS08270	COG3121	Chaperone
CH53_RS08275	COG3188	usher protein
CH53_RS08285	COG1335	isochorismatase
CH53_RS08295	COG3274	enterobacterial common antigen metabolic process
CH53_RS08305	COG3276	selenocysteine insertion sequence binding
CH53_RS08310	COG1921	L-seryl-tRNASec selenium transferase activity
CH53_RS08315	COG3058	Necessary for formate dehydrogenase activity
CH53_RS08320	COG2864	formate dehydrogenase
CH53_RS08325	COG0437	4 iron, 4 sulfur cluster binding
CH53_RS08330	COG0243	molybdopterin cofactor binding
CH53_RS08330	COG3383	formate dehydrogenase (NAD+) activity
CH53_RS08335	COG0243	molybdopterin cofactor binding
CH53_RS08335	COG3383	formate dehydrogenase (NAD+) activity
CH53_RS08340	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CH53_RS08345	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CH53_RS08350	COG0840	transmembrane signaling receptor activity
CH53_RS08355	COG2258	MOSC domain
CH53_RS08360	COG3077	Addiction module antitoxin, RelB DinJ family
CH53_RS08375	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CH53_RS08385	COG3722	fumarate hydratase activity
CH53_RS08390	COG0246	Mannitol dehydrogenase
CH53_RS08395	COG2213	PTS system mannitol-specific
CH53_RS08395	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH53_RS08405	COG0751	glycine-tRNA ligase activity
CH53_RS08415	COG2818	Glycosylase
CH53_RS08420	COG0456	acetyltransferase
CH53_RS08435	COG2885	chlorophyll binding
CH53_RS08455	COG0366	Alpha amylase catalytic
CH53_RS08460	COG3977	Valine--pyruvate aminotransferase
CH53_RS08480	COG5645	(Lipo)protein
CH53_RS08485	COG0823	Involved in the tonB-independent uptake of proteins
CH53_RS08490	COG2271	Major facilitator Superfamily
CH53_RS08495	COG4948	Mandelate Racemase Muconate Lactonizing
CH53_RS08500	COG0800	Aldolase
CH53_RS08505	COG3734	2-keto-3-deoxy-galactonokinase
CH53_RS08510	COG2186	Transcriptional regulator
CH53_RS08525	COG2423	ornithine cyclodeaminase activity
CH53_RS08530	COG2188	Transcriptional regulator
CH53_RS08535	COG2723	6-phospho-beta-galactosidase activity
CH53_RS08545	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CH53_RS08550	COG1940	carbohydrate kinase activity
CH53_RS08560	COG1447	Phosphotransferase system cellobiose-specific component IIA
CH53_RS08565	COG0561	phosphatase activity
CH53_RS08570	COG0187	DNA topoisomerase II activity
CH53_RS08580	COG0592	DNA-directed DNA polymerase activity
CH53_RS08585	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CH53_RS08595	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CH53_RS08600	COG0594	ribonuclease P activity
CH53_RS08610	COG0706	membrane insertase activity
CH53_RS08615	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CH53_RS08620	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CH53_RS08630	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CH53_RS08635	COG2011	ABC-type metal ion transport system permease component
CH53_RS08640	COG0840	transmembrane signaling receptor activity
CH53_RS08645	COG0431	NADPH-dependent FMN reductase
CH53_RS08650	COG4191	Histidine kinase
CH53_RS08665	COG2252	PERMEase
CH53_RS08670	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CH53_RS08675	COG0765	amino acid transport
CH53_RS08680	COG0765	amino acid transport
CH53_RS08685	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CH53_RS08695	COG0704	Plays a role in the regulation of phosphate uptake
CH53_RS08705	COG0581	inorganic phosphate transmembrane transporter activity
CH53_RS08710	COG0573	inorganic phosphate transmembrane transporter activity
CH53_RS08715	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CH53_RS08765	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CH53_RS08770	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CH53_RS08775	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CH53_RS08785	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CH53_RS08790	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CH53_RS08795	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CH53_RS08805	COG0356	it plays a direct role in the translocation of protons across the membrane
CH53_RS08810	COG3312	ion transport
CH53_RS08815	COG0357	Ribosomal RNA small subunit methyltransferase G
CH53_RS08820	COG0445	tRNA wobble uridine modification
CH53_RS08825	COG0716	FMN binding
CH53_RS08830	COG1522	sequence-specific DNA binding
CH53_RS08835	COG2502	aspartate--ammonia ligase
CH53_RS08845	COG2425	protein containing a von Willebrand factor type A (vWA) domain
CH53_RS08850	COG0714	Associated with various cellular activities
CH53_RS08855	COG3158	transport of potassium into the cell
CH53_RS08860	COG1869	D-ribose catabolic process
CH53_RS08870	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH53_RS08875	COG1879	ABC-type sugar transport system periplasmic component
CH53_RS08880	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CH53_RS08885	COG1609	Transcriptional regulator
CH53_RS08890	COG0477	Major facilitator Superfamily
CH53_RS08895	COG2186	Transcriptional regulator
CH53_RS08920	COG1763	Mo-molybdopterin cofactor biosynthetic process
CH53_RS08930	COG3084	Protein conserved in bacteria
CH53_RS08935	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CH53_RS08940	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CH53_RS08945	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CH53_RS08945	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CH53_RS08950	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CH53_RS08960	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CH53_RS08970	COG3852	Histidine kinase
CH53_RS08975	COG0174	glutamine synthetase
CH53_RS08985	COG1011	Hydrolase
CH53_RS08990	COG1295	ribonuclease BN
CH53_RS08995	COG1490	D-aminoacyl-tRNA deacylase activity
CH53_RS09000	COG0456	acetyltransferase
CH53_RS09005	COG2204	response regulator
CH53_RS09020	COG3423	Transcriptional regulator
CH53_RS09035	COG2982	Protein involved in outer membrane biogenesis
CH53_RS09040	COG2233	PERMEase
CH53_RS09045	COG0786	glutamate:sodium symporter activity
CH53_RS09050	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CH53_RS09055	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CH53_RS09060	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CH53_RS09065	COG1758	RNA polymerase activity
CH53_RS09075	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CH53_RS09080	COG2860	membrane
CH53_RS09090	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CH53_RS09095	COG1024	Enoyl-CoA hydratase
CH53_RS09100	COG5001	Diguanylate cyclase
CH53_RS09185	COG1561	YicC-like family, N-terminal region
CH53_RS09190	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CH53_RS09195	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CH53_RS09200	COG1309	transcriptional regulator
CH53_RS09205	COG0756	dUTP diphosphatase activity
CH53_RS09210	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CH53_RS09220	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CH53_RS09225	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CH53_RS09235	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CH53_RS09245	COG1519	Transferase
CH53_RS09250	COG0859	PFAM glycosyl transferase family 9
CH53_RS09260	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CH53_RS09265	COG0156	8-amino-7-oxononanoate synthase activity
CH53_RS09275	COG2861	carbohydrate metabolic process
CH53_RS09280	COG4942	peptidase
CH53_RS09285	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CH53_RS09290	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CH53_RS09295	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CH53_RS09300	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
CH53_RS09305	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CH53_RS09310	COG1045	serine acetyltransferase
CH53_RS09315	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CH53_RS09320	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CH53_RS09320	COG2169	Transcriptional regulator
CH53_RS09325	COG2205	protein histidine kinase activity
CH53_RS09330	COG0745	RESPONSE REGULATOR receiver
CH53_RS09335	COG3678	ATP-independent chaperone mediated protein folding
CH53_RS09345	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
CH53_RS09355	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CH53_RS09365	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
CH53_RS09380	COG3152	Membrane
CH53_RS09390	COG2814	Major facilitator Superfamily
CH53_RS09395	COG1494	fructose-1,6-bisphosphatase
CH53_RS09400	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CH53_RS09405	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CH53_RS09410	COG3074	FtsZ-dependent cytokinesis
CH53_RS09420	COG1575	Belongs to the MenA family. Type 1 subfamily
CH53_RS09425	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CH53_RS09430	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CH53_RS09435	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CH53_RS09440	COG1609	Transcriptional regulator
CH53_RS09445	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CH53_RS09450	COG0254	rRNA binding
CH53_RS09455	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
CH53_RS09460	COG0626	cystathionine gamma-synthase activity
CH53_RS09465	COG0527	aspartate kinase activity
CH53_RS09465	COG0460	homoserine dehydrogenase
CH53_RS09475	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CH53_RS09495	COG0165	Argininosuccinate lyase
CH53_RS09545	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CH53_RS09550	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CH53_RS09550	COG0678	peroxiredoxin activity
CH53_RS09560	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CH53_RS09575	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CH53_RS09585	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CH53_RS09625	COG1879	ABC-type sugar transport system periplasmic component
CH53_RS09630	COG1129	ABC transporter
CH53_RS09635	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH53_RS09640	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH53_RS09645	COG0583	DNA-binding transcription factor activity
CH53_RS09650	COG3085	chromosome segregation
CH53_RS09665	COG3978	acetolactate synthase activity
CH53_RS09670	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CH53_RS09680	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CH53_RS09690	COG0583	DNA-binding transcription factor activity
CH53_RS09695	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CH53_RS09705	COG3121	Chaperone
CH53_RS09720	COG3121	Chaperone
CH53_RS09730	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CH53_RS09745	COG0248	Ppx GppA phosphatase
CH53_RS09755	COG3118	belongs to the thioredoxin family
CH53_RS09760	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CH53_RS09765	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CH53_RS09770	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
CH53_RS09775	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CH53_RS09780	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CH53_RS09785	COG1088	dTDP-glucose 4,6-dehydratase activity
CH53_RS09790	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CH53_RS09795	COG0456	acetyltransferase
CH53_RS09800	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CH53_RS09805	COG2244	polysaccharide biosynthetic process
CH53_RS09810	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CH53_RS09850	COG3071	HemY protein
CH53_RS09855	COG2959	enzyme of heme biosynthesis
CH53_RS09860	COG1587	Uroporphyrinogen-III synthase
CH53_RS09865	COG0181	hydroxymethylbilane synthase activity
CH53_RS09870	COG3072	Adenylate cyclase
CH53_RS09880	COG5567	small periplasmic lipoprotein
CH53_RS09885	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CH53_RS09890	COG3159	Protein conserved in bacteria
CH53_RS09895	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
CH53_RS09900	COG1011	Hydrolase
CH53_RS09905	COG0210	DNA helicase
CH53_RS09915	COG5441	Belongs to the UPF0261 family
CH53_RS09920	COG5564	TIM-barrel signal transduction protein
CH53_RS09940	COG2050	protein possibly involved in aromatic compounds catabolism
CH53_RS09945	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
CH53_RS09950	COG0514	ATP-dependent DNA helicase (RecQ)
CH53_RS09955	COG1280	lysine exporter protein (LysE YggA)
CH53_RS09960	COG1280	lysine exporter protein (LysE YggA)
CH53_RS09965	COG2267	carboxylic ester hydrolase activity
CH53_RS09970	COG0561	phosphatase activity
CH53_RS09975	COG0584	glycerophosphoryl diester phosphodiesterase
CH53_RS09980	COG2271	Major facilitator Superfamily
CH53_RS09985	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CH53_RS09990	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
CH53_RS09995	COG0247	lactate metabolic process
CH53_RS10005	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
CH53_RS10010	COG0425	Belongs to the sulfur carrier protein TusA family
CH53_RS10015	COG2217	Heavy metal translocating P-type atpase
CH53_RS10020	COG3714	YhhN family
CH53_RS10035	COG3776	membrane
CH53_RS10040	COG0742	ribosomal rna small subunit methyltransferase
CH53_RS10045	COG0552	protein localization to endoplasmic reticulum
CH53_RS10050	COG2884	Cell division ATP-binding protein ftsE
CH53_RS10055	COG2177	Part of the ABC transporter FtsEX involved in
CH53_RS10065	COG0456	acetyltransferase
CH53_RS10070	COG0683	leucine binding
CH53_RS10080	COG4177	L-phenylalanine transmembrane transporter activity
CH53_RS10090	COG0410	ABC transporter
CH53_RS10125	COG1653	transport
CH53_RS10130	COG1175	transmembrane transport
CH53_RS10135	COG0395	ABC-type sugar transport system, permease component
CH53_RS10140	COG3842	ATPase activity
CH53_RS10145	COG0584	glycerophosphoryl diester phosphodiesterase
CH53_RS10150	COG0679	Auxin Efflux Carrier
CH53_RS10155	COG0697	spore germination
CH53_RS10160	COG0583	DNA-binding transcription factor activity
CH53_RS10165	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CH53_RS10170	COG0412	Dienelactone hydrolase
CH53_RS10185	COG1966	Carbon starvation protein
CH53_RS10190	COG0586	Pfam SNARE associated Golgi protein
CH53_RS10195	COG1322	Protein conserved in bacteria
CH53_RS10200	COG2226	methyltransferase
CH53_RS10205	COG3165	ubiquinone biosynthetic process from chorismate
CH53_RS10210	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CH53_RS10215	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CH53_RS10220	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CH53_RS10225	COG0805	protein transport
CH53_RS10245	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CH53_RS10255	COG0183	Belongs to the thiolase family
CH53_RS10260	COG1250	3-hydroxyacyl-CoA dehydrogenase
CH53_RS10260	COG1024	Enoyl-CoA hydratase
CH53_RS10270	COG1739	Uncharacterized protein family UPF0029
CH53_RS10275	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CH53_RS10310	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
CH53_RS10310	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
CH53_RS10315	COG1072	(Pantothenic acid kinase))
CH53_RS10355	COG0250	Participates in transcription elongation, termination and antitermination
CH53_RS10360	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CH53_RS10365	COG0081	regulation of translation
CH53_RS10370	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CH53_RS10375	COG0222	ribosome binding
CH53_RS10380	COG0085	RNA polymerase activity
CH53_RS10385	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CH53_RS10395	COG2022	thiamine diphosphate biosynthetic process
CH53_RS10400	COG2104	thiamine diphosphate biosynthetic process
CH53_RS10405	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CH53_RS10420	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
CH53_RS10425	COG2816	NAD+ diphosphatase activity
CH53_RS10430	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CH53_RS10435	COG1515	deoxyribonuclease V activity
CH53_RS10455	COG0151	Belongs to the GarS family
CH53_RS10460	COG0138	bifunctional purine biosynthesis protein purh
CH53_RS10500	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
CH53_RS10505	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CH53_RS10515	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
CH53_RS10520	COG0183	Belongs to the thiolase family
CH53_RS10525	COG2031	fatty acid transporter
CH53_RS10530	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CH53_RS10535	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CH53_RS10540	COG2204	response regulator
CH53_RS10545	COG3852	Histidine kinase
CH53_RS10575	COG0527	aspartate kinase activity
CH53_RS10585	COG3223	Belongs to the PsiE family
CH53_RS10590	COG3833	ABC-type maltose transport systems, permease component
CH53_RS10595	COG1175	transmembrane transport
CH53_RS10610	COG4580	involved in the transport of maltose and maltodextrins
CH53_RS10620	COG3161	chorismate lyase activity
CH53_RS10630	COG2937	Belongs to the GPAT DAPAT family
CH53_RS10635	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CH53_RS10640	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CH53_RS10645	COG3237	CsbD-like
CH53_RS10650	COG0735	belongs to the Fur family
CH53_RS10655	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CH53_RS10665	COG0604	alcohol dehydrogenase
CH53_RS10680	COG1448	Aminotransferase
CH53_RS10685	COG2315	Protein conserved in bacteria
CH53_RS10690	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CH53_RS10695	COG0629	single-stranded DNA binding
CH53_RS10700	COG3550	peptidyl-serine autophosphorylation
CH53_RS10715	COG2252	PERMEase
CH53_RS10720	COG0025	NhaP-type Na H and K H
CH53_RS10725	COG0583	DNA-binding transcription factor activity
CH53_RS10730	COG1380	Effector of murein hydrolase LrgA
CH53_RS10740	COG1126	abc transporter atp-binding protein
CH53_RS10745	COG0765	amino acid transport
CH53_RS10750	COG4597	amino acid ABC transporter
CH53_RS10755	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CH53_RS10765	COG1560	Kdo2-lipid A biosynthetic process
CH53_RS10775	COG1129	ABC transporter
CH53_RS10780	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH53_RS10790	COG1069	ribulokinase activity
CH53_RS10800	COG0471	metal ion transport
CH53_RS10805	COG1278	Cold shock
CH53_RS10810	COG1278	Cold shock
CH53_RS10815	COG3133	Outer membrane lipoprotein
CH53_RS10820	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
CH53_RS10825	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CH53_RS10830	COG2264	protein methyltransferase activity
CH53_RS10835	COG4145	pantothenate transmembrane transporter activity
CH53_RS10840	COG3924	membrane
CH53_RS10845	COG0439	Biotin carboxylase
CH53_RS10850	COG0511	ligase activity, forming carbon-carbon bonds
CH53_RS10860	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
CH53_RS10870	COG0604	alcohol dehydrogenase
CH53_RS10875	COG2200	EAL domain
CH53_RS10875	COG2199	diguanylate cyclase activity
CH53_RS10880	COG1077	Cell shape determining protein MreB Mrl
CH53_RS10885	COG1792	Involved in formation and maintenance of cell shape
CH53_RS10890	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
CH53_RS10895	COG0424	maF-like protein
CH53_RS10900	COG1530	ribonuclease E activity
CH53_RS10905	COG3164	Protein of unknown function
CH53_RS10910	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CH53_RS10915	COG0312	modulator of DNA gyrase
CH53_RS10920	COG0583	DNA-binding transcription factor activity
CH53_RS10930	COG1566	PFAM secretion protein HlyD family protein
CH53_RS10935	COG1289	transmembrane transporter activity
CH53_RS10940	COG1012	belongs to the aldehyde dehydrogenase family
CH53_RS10950	COG2732	(Barnase) inhibitor
CH53_RS10955	COG3028	Belongs to the UPF0307 family
CH53_RS10960	COG0312	modulator of DNA gyrase
CH53_RS10965	COG3783	Cytochrome b(562)
CH53_RS10970	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CH53_RS11000	COG3964	amidohydrolase
CH53_RS11015	COG3711	transcriptional antiterminator
CH53_RS11015	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH53_RS11020	COG3093	addiction module antidote protein HigA
CH53_RS11030	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CH53_RS11040	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CH53_RS11040	COG1263	PTS System
CH53_RS11045	COG0366	Alpha amylase catalytic
CH53_RS11060	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
CH53_RS11065	COG0540	Belongs to the ATCase OTCase family
CH53_RS11070	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CH53_RS11075	COG2271	Major facilitator Superfamily
CH53_RS11080	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH53_RS11085	COG1660	Displays ATPase and GTPase activities
CH53_RS11100	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CH53_RS11105	COG1137	ATPase activity
CH53_RS11110	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
CH53_RS11115	COG3117	lipopolysaccharide transmembrane transporter activity
CH53_RS11120	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
CH53_RS11125	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CH53_RS11125	COG0517	IMP dehydrogenase activity
CH53_RS11130	COG0530	calcium, potassium:sodium antiporter activity
CH53_RS11135	COG1127	ABC transporter
CH53_RS11140	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CH53_RS11145	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CH53_RS11150	COG2854	intermembrane phospholipid transfer
CH53_RS11155	COG3113	response to antibiotic
CH53_RS11160	COG5007	Belongs to the BolA IbaG family
CH53_RS11165	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CH53_RS11170	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CH53_RS11175	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CH53_RS11180	COG3105	Protein conserved in bacteria
CH53_RS11185	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
CH53_RS11190	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CH53_RS11195	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CH53_RS11200	COG0625	glutathione transferase activity
CH53_RS11205	COG2969	positive regulation of protein catabolic process
CH53_RS11215	COG0493	'glutamate synthase
CH53_RS11220	COG0067	glutamate synthase
CH53_RS11220	COG0069	glutamate synthase activity
CH53_RS11220	COG0070	glutamate synthase
CH53_RS11225	COG1242	4 iron, 4 sulfur cluster binding
CH53_RS11230	COG0784	Response regulator, receiver
CH53_RS11230	COG5002	protein histidine kinase activity
CH53_RS11230	COG2198	Histidine kinase
CH53_RS11235	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
CH53_RS11240	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CH53_RS11245	COG2823	Periplasmic or secreted lipoprotein
CH53_RS11250	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
CH53_RS11255	COG0792	nuclease activity
CH53_RS11265	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CH53_RS11290	COG1064	alcohol dehydrogenase
CH53_RS11295	COG1741	Belongs to the pirin family
CH53_RS11300	COG0583	DNA-binding transcription factor activity
CH53_RS11305	COG0435	Glutathione S-transferase
CH53_RS11310	COG2259	Doxx family
CH53_RS11320	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
CH53_RS11325	COG4575	ribosome binding
CH53_RS11340	COG0586	Pfam SNARE associated Golgi protein
CH53_RS11355	COG2271	Major facilitator Superfamily
CH53_RS11365	COG0246	Mannitol dehydrogenase
CH53_RS11370	COG2721	sulfolactate sulfo-lyase activity
CH53_RS11380	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
CH53_RS11385	COG0861	Integral membrane protein TerC family
CH53_RS11390	COG0673	inositol 2-dehydrogenase activity
CH53_RS11395	COG1451	nucleotide metabolic process
CH53_RS11405	COG2813	Specifically methylates the guanine in position
CH53_RS11410	COG1902	pentaerythritol trinitrate reductase activity
CH53_RS11410	COG0446	pyridine nucleotide-disulphide oxidoreductase
CH53_RS11420	COG2378	regulation of single-species biofilm formation
CH53_RS11430	COG3247	response to pH
CH53_RS11435	COG2814	Major facilitator Superfamily
CH53_RS11490	COG0358	DNA primase activity
CH53_RS11495	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CH53_RS11500	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CH53_RS11510	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CH53_RS11515	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CH53_RS11525	COG0617	tRNA 3'-terminal CCA addition
CH53_RS11530	COG4991	sh3 domain protein
CH53_RS11535	COG3025	triphosphatase activity
CH53_RS11540	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
CH53_RS11545	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CH53_RS11545	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
CH53_RS11550	COG0531	amino acid
CH53_RS11560	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CH53_RS11565	COG3384	dioxygenase
CH53_RS11570	COG0754	glutathionylspermidine amidase activity
CH53_RS11575	COG5463	Belongs to the UPF0441 family
CH53_RS11580	COG1538	Outer membrane efflux protein
CH53_RS11585	COG0494	nUDIX hydrolase
CH53_RS11590	COG3151	Protein conserved in bacteria
CH53_RS11595	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CH53_RS11600	COG3150	esterase
CH53_RS11610	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
CH53_RS11615	COG2249	NAD(P)H dehydrogenase (quinone) activity
CH53_RS11630	COG1653	transport
CH53_RS11635	COG0667	Aldo Keto reductase
CH53_RS11640	COG0583	DNA-binding transcription factor activity
CH53_RS11650	COG3716	PTS system mannose fructose sorbose family IID component
CH53_RS11655	COG3715	PTS system
CH53_RS11660	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CH53_RS11665	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CH53_RS11670	COG0204	Acyl-transferase
CH53_RS11675	COG2132	Multicopper oxidase
CH53_RS11695	COG0656	L-ascorbic acid biosynthetic process
CH53_RS11700	COG1979	alcohol dehydrogenase
CH53_RS11705	COG2207	Transcriptional regulator
CH53_RS11710	COG0586	Pfam SNARE associated Golgi protein
CH53_RS11715	COG0626	cystathionine gamma-synthase activity
CH53_RS11725	COG0848	biopolymer transport protein
CH53_RS11770	COG4964	Belongs to the GSP D family
CH53_RS11800	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CH53_RS11805	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CH53_RS11830	COG1120	ATPase activity
CH53_RS11835	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CH53_RS11840	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CH53_RS11845	COG4592	Periplasmic binding protein
CH53_RS11850	COG0840	transmembrane signaling receptor activity
CH53_RS11870	COG3133	Outer membrane lipoprotein
CH53_RS11875	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
CH53_RS11880	COG0437	4 iron, 4 sulfur cluster binding
CH53_RS11885	COG5557	Pfam Polysulphide reductase, NrfD
CH53_RS11890	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
CH53_RS11895	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
CH53_RS11900	COG1773	rubredoxin
CH53_RS11910	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CH53_RS11915	COG0298	carbon dioxide binding
CH53_RS11920	COG0409	Hydrogenase expression formation protein
CH53_RS11925	COG0309	Hydrogenase expression formation protein (HypE)
CH53_RS11930	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
CH53_RS11935	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
CH53_RS11940	COG5001	Diguanylate cyclase
CH53_RS11950	COG4303	Ethanolamine ammonia lyase large subunit
CH53_RS11955	COG4302	ethanolamine ammonia-lyase activity
CH53_RS11960	COG0477	Major facilitator Superfamily
CH53_RS11985	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
CH53_RS11990	COG2195	Cleaves the N-terminal amino acid of tripeptides
CH53_RS11995	COG1283	sodium-dependent phosphate transmembrane transporter activity
CH53_RS12000	COG4607	ABC-type enterochelin transport system periplasmic component
CH53_RS12010	COG4605	iron ion homeostasis
CH53_RS12015	COG4604	ABC transporter, ATP-binding protein
CH53_RS12075	COG1289	transmembrane transporter activity
CH53_RS12110	COG3121	Chaperone
CH53_RS12115	COG3121	Chaperone
CH53_RS12120	COG3188	usher protein
CH53_RS12145	COG3547	Transposase (IS116 IS110 IS902 family)
CH53_RS12220	COG2040	homocysteine
CH53_RS12225	COG0833	amino acid
CH53_RS12265	COG3038	cytochrome b561
CH53_RS12270	COG0789	Transcriptional regulator
CH53_RS12280	COG0300	oxidoreductase activity
CH53_RS12295	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CH53_RS12310	COG3447	MASE1 domain protein
CH53_RS12310	COG5002	protein histidine kinase activity
CH53_RS12310	COG5001	Diguanylate cyclase
CH53_RS12315	COG1105	Belongs to the carbohydrate kinase PfkB family
CH53_RS12330	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
CH53_RS12335	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CH53_RS12335	COG1263	PTS System
CH53_RS12335	COG2190	(PTS) system
CH53_RS12355	COG2188	Transcriptional regulator
CH53_RS12360	COG2771	luxR family
CH53_RS12365	COG3916	Acyl-homoserine-lactone synthase
CH53_RS12370	COG4810	utilization protein
CH53_RS12380	COG4766	ethanolamine catabolic process
CH53_RS12395	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
CH53_RS12400	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
CH53_RS12430	COG4303	Ethanolamine ammonia lyase large subunit
CH53_RS12455	COG2207	Transcriptional regulator
CH53_RS12505	COG2197	response regulator
CH53_RS12565	COG3121	Chaperone
CH53_RS12570	COG3188	usher protein
CH53_RS12645	COG2197	response regulator
CH53_RS12650	COG2197	response regulator
CH53_RS12655	COG0784	Response regulator, receiver
CH53_RS12655	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CH53_RS12655	COG2198	Histidine kinase
CH53_RS12655	COG2205	protein histidine kinase activity
CH53_RS12670	COG0288	reversible hydration of carbon dioxide
CH53_RS12675	COG2801	Transposase and inactivated derivatives
CH53_RS12680	COG2963	transposase activity
CH53_RS12700	COG1982	Orn Lys Arg decarboxylase major
CH53_RS12710	COG0741	lytic transglycosylase activity
CH53_RS12720	COG1194	a g-specific adenine glycosylase
CH53_RS12725	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CH53_RS12730	COG3171	Protein conserved in bacteria
CH53_RS12745	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CH53_RS12750	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CH53_RS12755	COG1872	DUF167
CH53_RS12760	COG0762	integral membrane protein
CH53_RS12765	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CH53_RS12770	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CH53_RS12775	COG2805	Type II/IV secretion system protein
CH53_RS12785	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CH53_RS12790	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CH53_RS12795	COG1678	Uncharacterized ACR, COG1678
CH53_RS12800	COG0189	ligase activity
CH53_RS12805	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CH53_RS12810	COG2356	endonuclease I
CH53_RS12815	COG3091	SprT-like family
CH53_RS12820	COG0640	Transcriptional regulator
CH53_RS12835	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CH53_RS12840	COG1166	arginine decarboxylase activity
CH53_RS12850	COG0501	Belongs to the peptidase M48B family
CH53_RS12855	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CH53_RS12860	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CH53_RS12865	COG0126	phosphoglycerate kinase activity
CH53_RS12870	COG0191	fructose-bisphosphate aldolase activity
CH53_RS12880	COG1279	arginine transmembrane transporter activity
CH53_RS12890	COG0583	DNA-binding transcription factor activity
CH53_RS12895	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CH53_RS12900	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CH53_RS12905	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CH53_RS12910	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
CH53_RS12915	COG3079	Belongs to the UPF0149 family
CH53_RS12920	COG0006	proline dipeptidase activity
CH53_RS12925	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CH53_RS12930	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CH53_RS12935	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CH53_RS12940	COG0509	glycine decarboxylation via glycine cleavage system
CH53_RS12945	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CH53_RS12945	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CH53_RS12950	COG1028	Short-chain dehydrogenase reductase Sdr
CH53_RS12960	COG1272	protein, Hemolysin III
CH53_RS12965	COG0354	folic acid binding
CH53_RS12980	COG0745	RESPONSE REGULATOR receiver
CH53_RS12985	COG2205	protein histidine kinase activity
CH53_RS12990	COG4452	Inner membrane protein CreD
CH53_RS12995	COG0716	FMN binding
CH53_RS13000	COG4974	Belongs to the 'phage' integrase family
CH53_RS13005	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CH53_RS13010	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CH53_RS13015	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CH53_RS13040	COG3706	GGDEF domain
CH53_RS13045	COG1522	sequence-specific DNA binding
CH53_RS13060	COG2271	Major facilitator Superfamily
CH53_RS13070	COG0484	heat shock protein binding
CH53_RS13080	COG1028	Short-chain dehydrogenase reductase Sdr
CH53_RS13085	COG1733	regulation of RNA biosynthetic process
CH53_RS13090	COG0288	reversible hydration of carbon dioxide
CH53_RS13185	COG0583	DNA-binding transcription factor activity
CH53_RS13190	COG0583	DNA-binding transcription factor activity
CH53_RS13205	COG1609	Transcriptional regulator
CH53_RS13215	COG0318	PFAM AMP-dependent synthetase and ligase
CH53_RS13215	COG0204	Acyl-transferase
CH53_RS13220	COG0477	Major facilitator Superfamily
CH53_RS13225	COG0667	Aldo Keto reductase
CH53_RS13235	COG0861	Integral membrane protein TerC family
CH53_RS13240	COG3066	DNA modification
CH53_RS13260	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CH53_RS13270	COG2165	general secretion pathway protein
CH53_RS13275	COG4795	General secretion pathway protein
CH53_RS13290	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
CH53_RS13295	COG1025	Belongs to the peptidase M16 family
CH53_RS13300	COG1074	ATP-dependent DNA helicase activity
CH53_RS13305	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CH53_RS13310	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CH53_RS13310	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
CH53_RS13315	COG0860	N-Acetylmuramoyl-L-alanine amidase
CH53_RS13335	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
CH53_RS13340	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CH53_RS13345	COG2166	iron-sulfur cluster assembly
CH53_RS13350	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CH53_RS13360	COG0583	DNA-binding transcription factor activity
CH53_RS13365	COG2363	Small membrane protein
CH53_RS13370	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
CH53_RS13375	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CH53_RS13380	COG1611	Belongs to the LOG family
CH53_RS13385	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CH53_RS13385	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CH53_RS13395	COG3098	single-species biofilm formation
CH53_RS13400	COG0564	pseudouridine synthase activity
CH53_RS13415	COG2171	N-acyltransferase activity
CH53_RS13420	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
CH53_RS13430	COG0052	Belongs to the universal ribosomal protein uS2 family
CH53_RS13435	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CH53_RS13440	COG0528	UMP kinase activity
CH53_RS13445	COG0233	cytoplasmic translational termination
CH53_RS13450	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CH53_RS13460	COG0575	Belongs to the CDS family
CH53_RS13465	COG0750	zinc metalloprotease
CH53_RS13475	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
CH53_RS13480	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CH53_RS13485	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CH53_RS13490	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CH53_RS13500	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CH53_RS13510	COG0825	malonyl-CoA metabolic process
CH53_RS13515	COG1982	Orn Lys Arg decarboxylase major
CH53_RS13520	COG0346	lactoylglutathione lyase activity
CH53_RS13535	COG4568	rho-dependent transcription termination
CH53_RS13545	COG4681	YaeQ
CH53_RS13555	COG3015	lipoprotein NlpE involved in copper resistance
CH53_RS13560	COG0442	prolyl-tRNA aminoacylation
CH53_RS13565	COG1720	tRNA m6t6A37 methyltransferase activity
CH53_RS13575	COG1464	Belongs to the NlpA lipoprotein family
CH53_RS13580	COG2011	ABC-type metal ion transport system permease component
CH53_RS13590	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CH53_RS13620	COG5544	Lipoprotein
CH53_RS13625	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CH53_RS13630	COG1042	CoA-binding domain protein
CH53_RS13630	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CH53_RS13630	COG0045	succinate-CoA ligase (ADP-forming) activity
CH53_RS13635	COG3148	PFAM DTW domain containing protein
CH53_RS13640	COG3118	belongs to the thioredoxin family
CH53_RS13645	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CH53_RS13650	COG2814	Major facilitator Superfamily
CH53_RS13655	COG1566	PFAM secretion protein HlyD family protein
CH53_RS13660	COG1846	Transcriptional regulator
CH53_RS13670	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
CH53_RS13675	COG2814	Major facilitator Superfamily
CH53_RS13690	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CH53_RS13705	COG0436	Aminotransferase
CH53_RS13710	COG0235	Class ii aldolase
CH53_RS13720	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
CH53_RS13730	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
CH53_RS13745	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
CH53_RS13750	COG1960	acyl-CoA dehydrogenase activity
CH53_RS13755	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
CH53_RS13760	COG0121	glutamine amidotransferase
CH53_RS13765	COG3034	peptidoglycan biosynthetic process
CH53_RS13775	COG1805	sodium ion transport
CH53_RS13780	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CH53_RS13785	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CH53_RS13790	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CH53_RS13795	COG2871	sodium ion transport
CH53_RS13800	COG1477	protein flavinylation
CH53_RS13805	COG2991	Protein conserved in bacteria
CH53_RS13815	COG1181	Belongs to the D-alanine--D-alanine ligase family
CH53_RS13820	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CH53_RS13825	COG2195	Cleaves the N-terminal amino acid of tripeptides
CH53_RS13835	COG1073	alpha beta
CH53_RS13845	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CH53_RS13850	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CH53_RS13855	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CH53_RS13860	COG2313	pseudouridylate synthase activity
CH53_RS13865	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CH53_RS13875	COG3459	Glycosyltransferase 36 associated
CH53_RS13890	COG2226	methyltransferase
CH53_RS13905	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CH53_RS13910	COG3123	guanosine phosphorylase activity
CH53_RS13915	COG2974	May be involved in recombination
CH53_RS13920	COG1940	carbohydrate kinase activity
CH53_RS13925	COG0419	ATPase involved in DNA repair
CH53_RS13930	COG0420	3'-5' exonuclease activity
CH53_RS13935	COG0745	RESPONSE REGULATOR receiver
CH53_RS13940	COG5002	protein histidine kinase activity
CH53_RS13960	COG0366	Alpha amylase catalytic
CH53_RS13975	COG0450	alkyl hydroperoxide reductase
CH53_RS13980	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
CH53_RS13995	COG1862	Preprotein translocase
CH53_RS14000	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CH53_RS14005	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CH53_RS14015	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CH53_RS14020	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CH53_RS14020	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CH53_RS14025	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CH53_RS14035	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CH53_RS14040	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CH53_RS14045	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CH53_RS14050	COG0142	geranyltranstransferase activity
CH53_RS14060	COG0301	tRNA thio-modification
CH53_RS14060	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CH53_RS14065	COG0693	protein deglycase activity
CH53_RS14070	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CH53_RS14075	COG1666	GTP binding
CH53_RS14080	COG2814	Major facilitator Superfamily
CH53_RS14085	COG0109	protoheme IX farnesyltransferase activity
CH53_RS14090	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
CH53_RS14095	COG1845	cytochrome c oxidase, subunit III
CH53_RS14100	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CH53_RS14105	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CH53_RS14115	COG2223	nitrite transmembrane transporter activity
CH53_RS14120	COG3056	Lipoprotein
CH53_RS14125	COG0271	Belongs to the BolA IbaG family
CH53_RS14135	COG0740	serine-type endopeptidase activity
CH53_RS14140	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CH53_RS14145	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CH53_RS14150	COG0776	regulation of translation
CH53_RS14155	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CH53_RS14160	COG1555	photosystem II stabilization
CH53_RS14165	COG0824	Thioesterase
CH53_RS14170	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CH53_RS14175	COG4533	DNA binding
CH53_RS14180	COG0561	phosphatase activity
CH53_RS14190	COG1522	sequence-specific DNA binding
CH53_RS14195	COG1132	(ABC) transporter
CH53_RS14200	COG1132	(ABC) transporter
CH53_RS14205	COG0347	Belongs to the P(II) protein family
CH53_RS14210	COG0004	ammonium transporteR
CH53_RS14215	COG1946	Acyl-CoA thioesterase
CH53_RS14220	COG3126	Type III secretion system lipoprotein chaperone (YscW)
CH53_RS14225	COG3695	enzyme binding
CH53_RS14245	COG1121	(ABC) transporter
CH53_RS14250	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CH53_RS14255	COG0803	Belongs to the bacterial solute-binding protein 9 family
CH53_RS14260	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CH53_RS14265	COG0254	rRNA binding
CH53_RS14270	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CH53_RS14275	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CH53_RS14280	COG1309	transcriptional regulator
CH53_RS14285	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
CH53_RS14290	COG1196	nuclear chromosome segregation
CH53_RS14290	COG3264	Mechanosensitive ion channel
CH53_RS14305	COG2832	Protein of unknown function (DUF454)
CH53_RS14310	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CH53_RS14320	COG0346	lactoylglutathione lyase activity
CH53_RS14325	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CH53_RS14330	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CH53_RS14335	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CH53_RS14340	COG0326	Molecular chaperone. Has ATPase activity
CH53_RS14345	COG0563	adenylate kinase activity
CH53_RS14350	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CH53_RS14355	COG2244	polysaccharide biosynthetic process
CH53_RS14360	COG1216	Glycosyl transferase, family 2
CH53_RS14360	COG1442	glycosyl transferase family 8
CH53_RS14365	COG1215	transferase activity, transferring glycosyl groups
CH53_RS14370	COG0438	transferase activity, transferring glycosyl groups
CH53_RS14375	COG0438	transferase activity, transferring glycosyl groups
CH53_RS14380	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CH53_RS14400	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CH53_RS14405	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CH53_RS14405	COG4651	solute:proton antiporter activity
CH53_RS14410	COG2223	nitrite transmembrane transporter activity
CH53_RS14415	COG0737	Belongs to the 5'-nucleotidase family
CH53_RS14420	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CH53_RS14425	COG3735	TraB family
CH53_RS14430	COG2217	Heavy metal translocating P-type atpase
CH53_RS14435	COG0789	Transcriptional regulator
CH53_RS14440	COG1585	Membrane protein implicated in regulation of membrane protease activity
CH53_RS14445	COG0330	HflC and HflK could
CH53_RS14450	COG3118	belongs to the thioredoxin family
CH53_RS14455	COG0300	oxidoreductase activity
CH53_RS14460	COG2755	lipolytic protein G-D-S-L family
CH53_RS14465	COG4181	ATPase activity
CH53_RS14470	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
CH53_RS14475	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CH53_RS14480	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CH53_RS14485	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CH53_RS14490	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CH53_RS14495	COG0215	cysteine-tRNA ligase activity
CH53_RS14500	COG2501	S4 domain
CH53_RS14505	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CH53_RS14515	COG0582	viral genome integration into host DNA
CH53_RS14540	COG2207	Transcriptional regulator
CH53_RS14550	COG0583	DNA-binding transcription factor activity
CH53_RS14555	COG0402	S-adenosylhomocysteine deaminase activity
CH53_RS14585	COG0583	DNA-binding transcription factor activity
CH53_RS14590	COG3268	Saccharopine dehydrogenase
CH53_RS14615	COG1309	transcriptional regulator
CH53_RS14620	COG2814	Major facilitator Superfamily
CH53_RS14625	COG1309	transcriptional regulator
CH53_RS14630	COG2826	transposase and inactivated derivatives, IS30 family
CH53_RS14650	COG0477	Major facilitator Superfamily
CH53_RS14655	COG0640	Transcriptional regulator
CH53_RS14660	COG0583	DNA-binding transcription factor activity
CH53_RS14665	COG0596	Alpha beta hydrolase
CH53_RS14720	COG0582	viral genome integration into host DNA
CH53_RS14725	COG0582	viral genome integration into host DNA
CH53_RS14740	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CH53_RS14745	COG1328	CTP reductase activity
CH53_RS14755	COG2211	Major facilitator Superfamily
CH53_RS14760	COG1486	melibiose metabolic process
CH53_RS14765	COG2169	Transcriptional regulator
CH53_RS14770	COG3240	lipase activity
CH53_RS14845	COG3122	Protein conserved in bacteria
CH53_RS14860	COG1401	restriction endodeoxyribonuclease activity
CH53_RS14875	COG0583	DNA-binding transcription factor activity
CH53_RS14890	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
CH53_RS14895	COG0583	DNA-binding transcription factor activity
CH53_RS14900	COG1028	Short-chain dehydrogenase reductase Sdr
CH53_RS14905	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CH53_RS14940	COG1902	pentaerythritol trinitrate reductase activity
CH53_RS14950	COG1028	Short-chain dehydrogenase reductase Sdr
CH53_RS14960	COG2610	gluconate transmembrane transporter activity
CH53_RS14975	COG1940	carbohydrate kinase activity
CH53_RS14980	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CH53_RS14985	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH53_RS14990	COG1129	ABC transporter
CH53_RS14995	COG1879	ABC-type sugar transport system periplasmic component
CH53_RS15000	COG1737	Transcriptional regulator
CH53_RS15005	COG0698	ribose 5-phosphate isomerase
CH53_RS15010	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CH53_RS15020	COG2850	peptidyl-arginine hydroxylation
CH53_RS15025	COG5265	(ABC) transporter
CH53_RS15040	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CH53_RS15050	COG2197	response regulator
CH53_RS15055	COG1278	Cold shock
CH53_RS15070	COG3706	GGDEF domain
CH53_RS15075	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CH53_RS15080	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CH53_RS15085	COG0321	lipoyl(octanoyl) transferase activity
CH53_RS15090	COG2921	Belongs to the UPF0250 family
CH53_RS15095	COG1686	Belongs to the peptidase S11 family
CH53_RS15100	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CH53_RS15105	COG0772	Belongs to the SEDS family
CH53_RS15110	COG0768	penicillin binding
CH53_RS15120	COG0799	negative regulation of ribosome biogenesis
CH53_RS15125	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CH53_RS15130	COG1466	dna polymerase III delta subunit
CH53_RS15135	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
CH53_RS15140	COG0495	leucyl-tRNA aminoacylation
CH53_RS15145	COG2888	peptidyl-tyrosine sulfation
CH53_RS15155	COG1126	abc transporter atp-binding protein
CH53_RS15160	COG0765	amino acid transport
CH53_RS15165	COG0765	amino acid transport
CH53_RS15180	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CH53_RS15190	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CH53_RS15195	COG1702	phosphate starvation-inducible protein PhoH
CH53_RS15200	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CH53_RS15205	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CH53_RS15250	COG0367	asparagine synthase
CH53_RS15255	COG0647	UMP catabolic process
CH53_RS15260	COG1846	Transcriptional regulator
CH53_RS15260	COG1940	carbohydrate kinase activity
CH53_RS15265	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CH53_RS15270	COG0363	glucosamine-6-phosphate deaminase activity
CH53_RS15275	COG1263	PTS System
CH53_RS15275	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CH53_RS15275	COG2190	(PTS) system
CH53_RS15280	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CH53_RS15300	COG0735	belongs to the Fur family
CH53_RS15310	COG0840	transmembrane signaling receptor activity
CH53_RS15320	COG0596	Alpha beta hydrolase
CH53_RS15325	COG2831	hemolysin activation secretion protein
CH53_RS15330	COG3210	domain, Protein
CH53_RS15375	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
CH53_RS15380	COG0033	Phosphoglucomutase
CH53_RS15390	COG0745	RESPONSE REGULATOR receiver
CH53_RS15395	COG2205	protein histidine kinase activity
CH53_RS15400	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
CH53_RS15405	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
CH53_RS15425	COG3272	Protein of unknown function (DUF1722)
CH53_RS15435	COG5212	phosphodiesterase
CH53_RS15440	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CH53_RS15445	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CH53_RS15450	COG1984	allophanate hydrolase subunit 2
CH53_RS15455	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CH53_RS15480	COG2009	succinate dehydrogenase
CH53_RS15485	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
CH53_RS15490	COG1053	succinate dehydrogenase
CH53_RS15500	COG0567	Dehydrogenase, E1 component
CH53_RS15505	COG0508	dehydrogenase complex catalyzes the overall conversion of
CH53_RS15510	COG0045	succinate-CoA ligase (ADP-forming) activity
CH53_RS15515	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CH53_RS15520	COG0737	Belongs to the 5'-nucleotidase family
CH53_RS15525	COG1271	oxidase subunit
CH53_RS15530	COG1294	oxidase, subunit
CH53_RS15535	COG4890	Cyd operon protein YbgT
CH53_RS15540	COG3790	cyd operon protein YbgE
CH53_RS15545	COG0824	Thioesterase
CH53_RS15550	COG0811	peptide transport
CH53_RS15555	COG0848	biopolymer transport protein
CH53_RS15560	COG3064	Membrane
CH53_RS15560	COG3064	Membrane
CH53_RS15565	COG0823	Involved in the tonB-independent uptake of proteins
CH53_RS15570	COG2885	chlorophyll binding
CH53_RS15575	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
CH53_RS15600	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CH53_RS15610	COG1230	cation diffusion facilitator family transporter
CH53_RS15615	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CH53_RS15615	COG2205	protein histidine kinase activity
CH53_RS15620	COG2197	response regulator
CH53_RS15625	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CH53_RS15630	COG0588	phosphoglycerate mutase activity
CH53_RS15640	COG2017	converts alpha-aldose to the beta-anomer
CH53_RS15645	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CH53_RS15655	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CH53_RS15670	COG1119	ATPase activity
CH53_RS15675	COG3585	molybdate ion transport
CH53_RS15675	COG2005	Transcriptional regulator
CH53_RS15685	COG0725	ABC transporter, periplasmic molybdate-binding protein
CH53_RS15690	COG4149	molybdate abc transporter
CH53_RS15700	COG0561	phosphatase activity
CH53_RS15705	COG2706	6-phosphogluconolactonase activity
CH53_RS15715	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CH53_RS15725	COG2226	methyltransferase
CH53_RS15740	COG0556	nucleotide-excision repair
CH53_RS15745	COG4628	conserved protein (DUF2132)
CH53_RS15750	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CH53_RS15755	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CH53_RS15760	COG0315	cyclic pyranopterin monophosphate synthase activity
CH53_RS15765	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
CH53_RS15770	COG0314	molybdopterin synthase activity
CH53_RS15775	COG0670	Belongs to the BI1 family
CH53_RS15780	COG0842	Transport permease protein
CH53_RS15785	COG0842	Transport permease protein
CH53_RS15790	COG1131	(ABC) transporter
CH53_RS15795	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CH53_RS15800	COG1309	transcriptional regulator
CH53_RS15805	COG0513	Belongs to the DEAD box helicase family
CH53_RS15810	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CH53_RS15815	COG2239	Acts as a magnesium transporter
CH53_RS15825	COG1686	Belongs to the peptidase S11 family
CH53_RS15830	COG0277	FAD linked oxidase domain protein
CH53_RS15850	COG2261	transglycosylase associated protein
CH53_RS15860	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
CH53_RS15875	COG4807	Protein conserved in bacteria
CH53_RS15905	COG2897	thiosulfate sulfurtransferase activity
CH53_RS15910	COG0673	inositol 2-dehydrogenase activity
CH53_RS15920	COG1732	Glycine betaine
CH53_RS15925	COG1174	glycine betaine transport
CH53_RS15930	COG1125	glycine betaine transport
CH53_RS15935	COG1174	glycine betaine transport
CH53_RS15945	COG1028	Short-chain dehydrogenase reductase Sdr
CH53_RS15950	COG0583	DNA-binding transcription factor activity
CH53_RS15960	COG0697	spore germination
CH53_RS15980	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CH53_RS15985	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CH53_RS15990	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
CH53_RS15995	COG1126	abc transporter atp-binding protein
CH53_RS16000	COG0765	amino acid transport
CH53_RS16005	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CH53_RS16010	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CH53_RS16020	COG4106	trans-aconitate 2-methyltransferase activity
CH53_RS16035	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
CH53_RS16055	COG0488	(ABC) transporter
CH53_RS16060	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CH53_RS16065	COG0303	'Molybdopterin
CH53_RS16075	COG0477	Major facilitator Superfamily
CH53_RS16085	COG1136	(ABC) transporter
CH53_RS16115	COG0583	DNA-binding transcription factor activity
CH53_RS16120	COG0477	Major facilitator Superfamily
CH53_RS16125	COG0302	gtp cyclohydrolase
CH53_RS16130	COG2311	Membrane
CH53_RS16135	COG1609	Transcriptional regulator
CH53_RS16155	COG2116	formate transmembrane transporter activity
CH53_RS16160	COG3604	Transcriptional regulator
CH53_RS16165	COG3383	formate dehydrogenase (NAD+) activity
CH53_RS16170	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CH53_RS16175	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
CH53_RS16185	COG3260	NADH ubiquinone oxidoreductase 20
CH53_RS16190	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CH53_RS16195	COG3261	NADH dehydrogenase
CH53_RS16195	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
CH53_RS16200	COG0651	ATP synthesis coupled electron transport
CH53_RS16205	COG4237	Hydrogenase 4 membrane
CH53_RS16210	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CH53_RS16215	COG0650	Formate hydrogenlyase subunit 4
CH53_RS16220	COG0651	ATP synthesis coupled electron transport
CH53_RS16225	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CH53_RS16230	COG0375	protein maturation
CH53_RS16235	COG0298	carbon dioxide binding
CH53_RS16245	COG2949	membrane
CH53_RS16250	COG0281	malic enzyme
CH53_RS16260	COG1346	cytolysis
CH53_RS16265	COG1380	Effector of murein hydrolase LrgA
CH53_RS16270	COG2814	Major facilitator Superfamily
CH53_RS16290	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CH53_RS16290	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CH53_RS16295	COG0489	protein tyrosine kinase activity
CH53_RS16300	COG0572	uridine kinase
CH53_RS16310	COG2982	Protein involved in outer membrane biogenesis
CH53_RS16315	COG3069	C4-dicarboxylate transmembrane transporter activity
CH53_RS16320	COG1253	flavin adenine dinucleotide binding
CH53_RS16385	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
CH53_RS16390	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CH53_RS16405	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CH53_RS16410	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CH53_RS16415	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CH53_RS16420	COG0140	phosphoribosyl-ATP diphosphatase activity
CH53_RS16420	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CH53_RS16425	COG0107	imidazoleglycerol-phosphate synthase activity
CH53_RS16440	COG0131	Imidazoleglycerol-phosphate dehydratase
CH53_RS16440	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CH53_RS16445	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CH53_RS16455	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CH53_RS16460	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CH53_RS16465	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH53_RS16470	COG1129	ABC transporter
CH53_RS16475	COG0371	Dehydrogenase
CH53_RS16485	COG0531	amino acid
CH53_RS16490	COG2925	Exonuclease
CH53_RS16510	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH53_RS16515	COG1129	ABC transporter
CH53_RS16530	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CH53_RS16540	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CH53_RS16560	COG4656	Part of a membrane complex involved in electron transport
CH53_RS16575	COG2096	Adenosyltransferase
CH53_RS16580	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
CH53_RS16595	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
CH53_RS16655	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
CH53_RS16665	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
CH53_RS16730	COG1492	cobalamin metabolic process
CH53_RS16750	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CH53_RS16755	COG0583	DNA-binding transcription factor activity
CH53_RS16765	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
CH53_RS16770	COG2211	Major facilitator Superfamily
CH53_RS16775	COG0137	argininosuccinate synthase activity
CH53_RS16780	COG0534	Mate efflux family protein
CH53_RS16785	COG0835	chemotaxis
CH53_RS16785	COG0784	Response regulator, receiver
CH53_RS16805	COG0561	phosphatase activity
CH53_RS16810	COG1349	DNA-binding transcription factor activity
CH53_RS16820	COG0583	DNA-binding transcription factor activity
CH53_RS16845	COG3047	cAMP biosynthetic process
CH53_RS16845	COG2885	chlorophyll binding
CH53_RS16935	COG3121	Chaperone
CH53_RS16965	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CH53_RS16965	COG2205	protein histidine kinase activity
CH53_RS16980	COG3842	ATPase activity
CH53_RS16990	COG1840	ABC-type Fe3 transport system, periplasmic component
CH53_RS16995	COG2271	Major facilitator Superfamily
CH53_RS17010	COG4565	transcriptional regulatory protein
CH53_RS17015	COG3290	protein histidine kinase activity
CH53_RS17020	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
CH53_RS17025	COG3052	prosthetic group binding
CH53_RS17030	COG2301	Belongs to the HpcH HpaI aldolase family
CH53_RS17035	COG3051	citrate lyase alpha subunit
CH53_RS17050	COG0471	metal ion transport
CH53_RS17065	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CH53_RS17075	COG2814	Major facilitator Superfamily
CH53_RS17085	COG2211	Major facilitator Superfamily
CH53_RS17100	COG2204	response regulator
CH53_RS17285	COG0582	viral genome integration into host DNA
CH53_RS17300	COG0582	viral genome integration into host DNA
CH53_RS17310	COG3228	Belongs to the MtfA family
CH53_RS17330	COG3121	Chaperone
CH53_RS17345	COG3121	Chaperone
CH53_RS17350	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CH53_RS17380	COG0604	alcohol dehydrogenase
CH53_RS17380	COG1028	Short-chain dehydrogenase reductase Sdr
CH53_RS17380	COG3321	synthase
CH53_RS17390	COG3250	beta-galactosidase activity
CH53_RS17395	COG1609	Transcriptional regulator
CH53_RS17410	COG0840	transmembrane signaling receptor activity
CH53_RS17415	COG1285	pathogenesis
CH53_RS17425	COG2130	NADP-dependent
CH53_RS17430	COG0589	response to stress
CH53_RS17455	COG2198	Histidine kinase
CH53_RS17455	COG0643	Histidine kinase
CH53_RS17460	COG0835	chemotaxis
CH53_RS17465	COG0840	transmembrane signaling receptor activity
CH53_RS17470	COG0840	transmembrane signaling receptor activity
CH53_RS17475	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CH53_RS17485	COG0745	RESPONSE REGULATOR receiver
CH53_RS17490	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
CH53_RS17495	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CH53_RS17500	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CH53_RS17510	COG3418	PFAM FlgN family protein
CH53_RS17515	COG2747	anti-sigma28 factor FlgM
CH53_RS17525	COG1815	bacterial-type flagellum-dependent cell motility
CH53_RS17530	COG1558	bacterial-type flagellum-dependent cell motility
CH53_RS17535	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CH53_RS17570	COG1256	bacterial-type flagellum assembly
CH53_RS17575	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CH53_RS17630	COG1317	bacterial-type flagellum organization
CH53_RS17645	COG1677	Flagellar hook-basal body complex protein FliE
CH53_RS17650	COG0582	viral genome integration into host DNA
CH53_RS17695	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
CH53_RS17700	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CH53_RS17730	COG1191	sigma factor activity
CH53_RS17740	COG2515	1-aminocyclopropane-1-carboxylate deaminase
CH53_RS17745	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CH53_RS17750	COG0765	amino acid transport
CH53_RS17755	COG1126	abc transporter atp-binding protein
CH53_RS17765	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CH53_RS17765	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CH53_RS17765	COG0506	proline dehydrogenase activity
CH53_RS17770	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CH53_RS17775	COG0672	)-iron permease
CH53_RS17780	COG2822	iron ion transport
CH53_RS17800	COG1881	PFAM PEBP family protein
CH53_RS17810	COG1113	amino acid transport
CH53_RS17820	COG0582	viral genome integration into host DNA
CH53_RS17825	COG2203	Gaf domain
CH53_RS17825	COG2199	diguanylate cyclase activity
CH53_RS17845	COG0366	Alpha amylase catalytic
CH53_RS17850	COG0840	transmembrane signaling receptor activity
CH53_RS17860	COG3136	membrane protein required for alginate biosynthesis
CH53_RS17870	COG2197	response regulator
CH53_RS17875	COG0322	excinuclease ABC activity
CH53_RS17880	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CH53_RS17925	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
CH53_RS17940	COG4626	Terminase
CH53_RS17940	COG1802	Transcriptional regulator
CH53_RS17965	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
CH53_RS18035	COG1733	regulation of RNA biosynthetic process
CH53_RS18055	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CH53_RS18115	COG3121	Chaperone
CH53_RS18120	COG3188	usher protein
CH53_RS18150	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CH53_RS18155	COG0561	phosphatase activity
CH53_RS18160	COG2223	nitrite transmembrane transporter activity
CH53_RS18175	COG2197	response regulator
CH53_RS18180	COG2223	nitrite transmembrane transporter activity
CH53_RS18185	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
CH53_RS18190	COG1140	nitrate reductase beta subunit
CH53_RS18195	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
CH53_RS18200	COG2181	nitrate reductase activity
CH53_RS18210	COG3493	citrate carrier protein
CH53_RS18215	COG4565	transcriptional regulatory protein
CH53_RS18220	COG3290	protein histidine kinase activity
CH53_RS18225	COG1349	DNA-binding transcription factor activity
CH53_RS18230	COG2084	Dehydrogenase
CH53_RS18235	COG3395	kinase activity
CH53_RS18240	COG0235	Class ii aldolase
CH53_RS18245	COG3622	Belongs to the hyi family
CH53_RS18255	COG1609	Transcriptional regulator
CH53_RS18260	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CH53_RS18265	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CH53_RS18270	COG2723	6-phospho-beta-galactosidase activity
CH53_RS18275	COG1447	Phosphotransferase system cellobiose-specific component IIA
CH53_RS18285	COG0672	)-iron permease
CH53_RS18300	COG0577	efflux transmembrane transporter activity
CH53_RS18300	COG1136	(ABC) transporter
CH53_RS18310	COG1136	(ABC) transporter
CH53_RS18310	COG0577	efflux transmembrane transporter activity
CH53_RS18335	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CH53_RS18340	COG0006	proline dipeptidase activity
CH53_RS18345	COG0457	Tetratricopeptide repeat
CH53_RS18350	COG1649	PFAM Uncharacterised BCR, COG1649
CH53_RS18350	COG0726	polysaccharide deacetylase
CH53_RS18355	COG1215	transferase activity, transferring glycosyl groups
CH53_RS18360	COG3658	cytochrome
CH53_RS18370	COG1702	phosphate starvation-inducible protein PhoH
CH53_RS18375	COG0387	Pfam Sodium calcium exchanger
CH53_RS18385	COG2814	Major facilitator Superfamily
CH53_RS18390	COG0583	DNA-binding transcription factor activity
CH53_RS18395	COG3850	Histidine kinase
CH53_RS18400	COG1294	oxidase, subunit
CH53_RS18405	COG1271	oxidase subunit
CH53_RS18410	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CH53_RS18415	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CH53_RS18420	COG3138	arginine N-succinyltransferase
CH53_RS18430	COG3724	N-succinylarginine dihydrolase activity
CH53_RS18450	COG1228	amidohydrolase
CH53_RS18460	COG0402	S-adenosylhomocysteine deaminase activity
CH53_RS18475	COG1129	ABC transporter
CH53_RS18480	COG4211	Belongs to the binding-protein-dependent transport system permease family
CH53_RS18495	COG2814	Major facilitator Superfamily
CH53_RS18505	COG1309	transcriptional regulator
CH53_RS18510	COG3443	Belongs to the bacterial solute-binding protein 9 family
CH53_RS18520	COG4942	peptidase
CH53_RS18530	COG0012	GTP binding
CH53_RS18540	COG0193	aminoacyl-tRNA hydrolase activity
CH53_RS18550	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CH53_RS18560	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
CH53_RS18565	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CH53_RS18570	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CH53_RS18575	COG2890	protein-(glutamine-N5) methyltransferase activity
CH53_RS18595	COG0659	secondary active sulfate transmembrane transporter activity
CH53_RS18600	COG3706	GGDEF domain
CH53_RS18620	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CH53_RS18630	COG3381	protein complex oligomerization
CH53_RS18640	COG0477	Major facilitator Superfamily
CH53_RS18670	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CH53_RS18695	COG3102	Protein conserved in bacteria
CH53_RS18700	COG3142	Participates in the control of copper homeostasis
CH53_RS18715	COG3788	relative of glutathione S-transferase, MAPEG superfamily
CH53_RS18720	COG1801	Protein of unknown function DUF72
CH53_RS18725	COG1335	isochorismatase
CH53_RS18730	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CH53_RS18735	COG0494	nUDIX hydrolase
CH53_RS18740	COG0217	transcriptional regulatory protein
CH53_RS18750	COG0632	four-way junction helicase activity
CH53_RS18755	COG2255	four-way junction helicase activity
CH53_RS18760	COG3104	oligopeptide transport
CH53_RS18765	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CH53_RS18770	COG1121	(ABC) transporter
CH53_RS18775	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
CH53_RS18780	COG0739	heme binding
CH53_RS18785	COG1560	Kdo2-lipid A biosynthetic process
CH53_RS18790	COG0469	pyruvate kinase activity
CH53_RS18795	COG1737	Transcriptional regulator
CH53_RS18800	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CH53_RS18805	COG0800	Aldolase
CH53_RS18810	COG2076	Multidrug Resistance protein
CH53_RS18815	COG2076	Multidrug Resistance protein
CH53_RS18820	COG0251	oxidation-reduction process
CH53_RS18825	COG1199	ATP-dependent helicase activity
CH53_RS18835	COG3065	identical protein binding
CH53_RS18840	COG0318	PFAM AMP-dependent synthetase and ligase
CH53_RS18845	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
CH53_RS18850	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
CH53_RS18855	COG2894	cell division
CH53_RS18860	COG0850	regulation of cytokinetic process
CH53_RS18870	COG3100	YcgL domain-containing protein
CH53_RS18875	COG2951	lytic endotransglycosylase activity
CH53_RS18880	COG0179	Fumarylacetoacetate (FAA) hydrolase
CH53_RS18885	COG2983	Belongs to the UPF0260 family
CH53_RS18895	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CH53_RS18915	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
CH53_RS18920	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CH53_RS18925	COG2186	Transcriptional regulator
CH53_RS18930	COG2719	SpoVR family
CH53_RS18935	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CH53_RS18940	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CH53_RS18945	COG2814	Major facilitator Superfamily
CH53_RS18950	COG2202	Pas domain
CH53_RS18950	COG2200	EAL domain
CH53_RS18950	COG2199	diguanylate cyclase activity
CH53_RS18960	COG2718	Belongs to the UPF0229 family
CH53_RS18965	COG2766	serine protein kinase
CH53_RS18970	COG3713	MltA-interacting MipA family protein
CH53_RS18990	COG3139	Protein of unknown function (DUF1315)
CH53_RS18995	COG1335	isochorismatase
CH53_RS19000	COG0252	asparaginase activity
CH53_RS19005	COG0616	signal peptide processing
CH53_RS19010	COG0778	Nitroreductase
CH53_RS19020	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CH53_RS19030	COG0494	nUDIX hydrolase
CH53_RS19035	COG0708	Exodeoxyribonuclease III
CH53_RS19040	COG0583	DNA-binding transcription factor activity
CH53_RS19055	COG0788	formyltetrahydrofolate deformylase activity
CH53_RS19060	COG3012	SEC-C Motif Domain Protein
CH53_RS19065	COG1752	Esterase of the alpha-beta hydrolase superfamily
CH53_RS19070	COG0745	RESPONSE REGULATOR receiver
CH53_RS19080	COG2916	Histone family protein nucleoid-structuring protein H-NS
CH53_RS19095	COG1454	alcohol dehydrogenase
CH53_RS19095	COG1012	belongs to the aldehyde dehydrogenase family
CH53_RS19100	COG2095	MarC family integral membrane protein
CH53_RS19105	COG4166	transmembrane transport
CH53_RS19120	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CH53_RS19125	COG0444	Belongs to the ABC transporter superfamily
CH53_RS19135	COG3099	Belongs to the UPF0263 family
CH53_RS19140	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CH53_RS19160	COG2350	Protein conserved in bacteria
CH53_RS19165	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
CH53_RS19175	COG2917	probably involved in intracellular septation
CH53_RS19190	COG0727	PFAM Uncharacterised protein family (UPF0153)
CH53_RS19195	COG3047	cAMP biosynthetic process
CH53_RS19205	COG0159	tryptophan synthase activity
CH53_RS19210	COG0133	tryptophan synthase activity
CH53_RS19215	COG0134	indole-3-glycerol-phosphate synthase activity
CH53_RS19215	COG0135	phosphoribosylanthranilate isomerase activity
CH53_RS19225	COG0512	Glutamine amidotransferase of anthranilate synthase
CH53_RS19235	COG0613	PHP domain protein
CH53_RS19240	COG0009	L-threonylcarbamoyladenylate synthase
CH53_RS19250	COG1187	pseudouridine synthase activity
CH53_RS19260	COG1028	Short-chain dehydrogenase reductase Sdr
CH53_RS19265	COG0616	signal peptide processing
CH53_RS19280	COG0583	DNA-binding transcription factor activity
CH53_RS19290	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CH53_RS19300	COG0671	phosphoesterase, PA-phosphatase related
CH53_RS19305	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
CH53_RS19310	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
CH53_RS19330	COG0023	Translation Initiation Factor
CH53_RS19340	COG0235	Class ii aldolase
CH53_RS19350	COG1349	DNA-binding transcription factor activity
CH53_RS19355	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CH53_RS19360	COG2879	small protein
CH53_RS19365	COG1966	Carbon starvation protein
CH53_RS19370	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
CH53_RS19375	COG0243	molybdopterin cofactor binding
CH53_RS19380	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CH53_RS19390	COG4659	FMN binding
CH53_RS19395	COG4658	electron transport chain
CH53_RS19400	COG2207	Transcriptional regulator
CH53_RS19400	COG3708	Transcriptional regulator
CH53_RS19405	COG4656	Part of a membrane complex involved in electron transport
CH53_RS19415	COG4657	Part of a membrane complex involved in electron transport
CH53_RS19425	COG2759	Belongs to the formate--tetrahydrofolate ligase family
CH53_RS19435	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CH53_RS19440	COG2274	protein secretion by the type I secretion system
CH53_RS19445	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CH53_RS19460	COG1879	ABC-type sugar transport system periplasmic component
CH53_RS19465	COG1129	ABC transporter
CH53_RS19470	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH53_RS19480	COG0673	inositol 2-dehydrogenase activity
CH53_RS19485	COG0385	Bile acid
CH53_RS19490	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CH53_RS19495	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CH53_RS19495	COG2190	(PTS) system
CH53_RS19495	COG1263	PTS System
CH53_RS19500	COG4948	Mandelate Racemase Muconate Lactonizing
CH53_RS19505	COG2188	Transcriptional regulator
CH53_RS19510	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CH53_RS19515	COG1263	PTS System
CH53_RS19515	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CH53_RS19520	COG1609	Transcriptional regulator
CH53_RS19530	COG5339	Protein conserved in bacteria
CH53_RS19540	COG0114	fumarate hydratase activity
CH53_RS19560	COG2814	Major facilitator Superfamily
CH53_RS19565	COG0583	DNA-binding transcription factor activity
CH53_RS19570	COG1940	carbohydrate kinase activity
CH53_RS19575	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CH53_RS19595	COG1742	UPF0060 membrane protein
CH53_RS19605	COG4221	oxidoreductase activity
CH53_RS19610	COG0110	maltose O-acetyltransferase activity
CH53_RS19620	COG1649	PFAM Uncharacterised BCR, COG1649
CH53_RS19640	COG1393	Belongs to the ArsC family
CH53_RS19645	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CH53_RS19670	COG0625	glutathione transferase activity
CH53_RS19675	COG3604	Transcriptional regulator
CH53_RS19680	COG1773	rubredoxin
CH53_RS19680	COG0426	domain, Protein
CH53_RS19685	COG0446	pyridine nucleotide-disulphide oxidoreductase
CH53_RS19695	COG1522	sequence-specific DNA binding
CH53_RS19705	COG4215	(ABC) transporter
CH53_RS19720	COG1477	protein flavinylation
CH53_RS19725	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CH53_RS19735	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CH53_RS19760	COG0028	Belongs to the TPP enzyme family
CH53_RS19765	COG0440	acetolactate synthase activity
CH53_RS19770	COG0251	oxidation-reduction process
CH53_RS19775	COG1011	Hydrolase
CH53_RS19785	COG0583	DNA-binding transcription factor activity
CH53_RS19800	COG0738	Major facilitator superfamily
CH53_RS19805	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CH53_RS19815	COG1028	Short-chain dehydrogenase reductase Sdr
CH53_RS19825	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
CH53_RS19840	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CH53_RS19845	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CH53_RS19850	COG0589	response to stress
CH53_RS19855	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
CH53_RS19860	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
CH53_RS19875	COG0531	amino acid
CH53_RS19885	COG0745	RESPONSE REGULATOR receiver
CH53_RS19890	COG2205	protein histidine kinase activity
CH53_RS19895	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
CH53_RS19905	COG3591	Belongs to the peptidase S1B family
CH53_RS19920	COG1643	Atp-dependent helicase
CH53_RS19925	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CH53_RS19930	COG3784	Protein of unknown function (DUF1318)
CH53_RS19940	COG2911	Protein conserved in bacteria
CH53_RS19945	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CH53_RS19950	COG3042	response to heat
CH53_RS19955	COG1285	pathogenesis
CH53_RS19965	COG0674	pyruvate-flavodoxin oxidoreductase activity
CH53_RS19965	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CH53_RS19965	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CH53_RS19965	COG1013	pyruvate-flavodoxin oxidoreductase activity
CH53_RS19970	COG0037	tRNA processing
CH53_RS19975	COG0598	Magnesium transport protein CorA
CH53_RS19980	COG4166	transmembrane transport
CH53_RS19985	COG2866	Carboxypeptidase
CH53_RS19990	COG4948	Mandelate Racemase Muconate Lactonizing
CH53_RS19995	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CH53_RS20005	COG5642	Protein of unknown function (DUF2384)
CH53_RS20010	COG5654	RES domain protein
CH53_RS20015	COG3768	UPF0283 membrane protein
CH53_RS20020	COG3106	COG3106 Predicted ATPase
CH53_RS20030	COG1983	PspC domain protein
CH53_RS20040	COG1842	Phage shock protein A
CH53_RS20045	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
CH53_RS20060	COG4166	transmembrane transport
CH53_RS20065	COG4168	peptide transport system, permease
CH53_RS20070	COG4171	peptide transport system, permease
CH53_RS20080	COG4172	Belongs to the ABC transporter superfamily
CH53_RS20090	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CH53_RS20090	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CH53_RS20100	COG3104	oligopeptide transport
CH53_RS20120	COG0625	glutathione transferase activity
CH53_RS20130	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CH53_RS20140	COG3895	Periplasmic Protein
CH53_RS20145	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
CH53_RS20150	COG3133	Outer membrane lipoprotein
CH53_RS20155	COG1846	Transcriptional regulator
CH53_RS20165	COG1566	PFAM secretion protein HlyD family protein
CH53_RS20170	COG1289	transmembrane transporter activity
CH53_RS20175	COG4989	oxidoreductase activity
CH53_RS20180	COG3313	Fe-S protein
CH53_RS20185	COG2194	sulfuric ester hydrolase activity
CH53_RS20190	COG1309	transcriptional regulator
CH53_RS20195	COG1902	pentaerythritol trinitrate reductase activity
CH53_RS20200	COG0346	lactoylglutathione lyase activity
CH53_RS20205	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CH53_RS20210	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CH53_RS20215	COG0791	NLP P60 protein
CH53_RS20225	COG1609	Transcriptional regulator
CH53_RS20230	COG0583	DNA-binding transcription factor activity
CH53_RS20235	COG2814	Major facilitator Superfamily
CH53_RS20240	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CH53_RS20245	COG0307	riboflavin synthase, alpha
CH53_RS20250	COG0534	Mate efflux family protein
CH53_RS20280	COG1388	LysM domain
CH53_RS20280	COG1376	ErfK ybiS ycfS ynhG family protein
CH53_RS20285	COG2166	iron-sulfur cluster assembly
CH53_RS20295	COG0719	Fe-S assembly protein
CH53_RS20300	COG0396	ATPase activity
CH53_RS20305	COG0719	Fe-S assembly protein
CH53_RS20310	COG0316	Belongs to the HesB IscA family
CH53_RS20315	COG2050	protein possibly involved in aromatic compounds catabolism
CH53_RS20320	COG0277	FAD linked oxidase domain protein
CH53_RS20320	COG0247	lactate metabolic process
CH53_RS20325	COG0628	permease
CH53_RS20330	COG0574	Belongs to the PEP-utilizing enzyme family
CH53_RS20330	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CH53_RS20335	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CH53_RS20340	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CH53_RS20355	COG3720	iron ion transport
CH53_RS20360	COG4558	Periplasmic binding protein
CH53_RS20370	COG0095	Lipoate-protein ligase
CH53_RS20375	COG0791	NLP P60 protein
CH53_RS20380	COG2076	Multidrug Resistance protein
CH53_RS20385	COG2076	Multidrug Resistance protein
CH53_RS20390	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CH53_RS20395	COG0726	polysaccharide deacetylase
CH53_RS20405	COG0463	Glycosyl transferase, family 2
CH53_RS20410	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CH53_RS20415	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
CH53_RS20420	COG0386	Belongs to the glutathione peroxidase family
CH53_RS20425	COG4139	cobalamin transport
CH53_RS20435	COG0776	regulation of translation
CH53_RS20455	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CH53_RS20460	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CH53_RS20640	COG3646	Phage regulatory protein
CH53_RS20655	COG3772	lysozyme
CH53_RS20710	COG0305	Participates in initiation and elongation during chromosome replication
CH53_RS20765	COG4712	double-strand break repair protein
CH53_RS20770	COG0629	single-stranded DNA binding
CH53_RS20830	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CH53_RS20850	COG4249	Peptidase C14 caspase catalytic subunit p20
CH53_RS20855	COG1811	Na channel or pump
CH53_RS20860	COG1414	Transcriptional regulator
CH53_RS20865	COG1129	ABC transporter
CH53_RS20870	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH53_RS20890	COG1070	Carbohydrate kinase
CH53_RS20895	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
CH53_RS20900	COG3623	hexulose-6-phosphate isomerase
CH53_RS20930	COG0803	Belongs to the bacterial solute-binding protein 9 family
CH53_RS20935	COG1121	(ABC) transporter
CH53_RS20940	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CH53_RS20945	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CH53_RS20950	COG3001	Fructosamine kinase
CH53_RS20955	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CH53_RS20955	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CH53_RS20960	COG1703	isobutyryl-CoA mutase activity
CH53_RS20965	COG1024	Enoyl-CoA hydratase
CH53_RS20970	COG0427	acetyl-CoA hydrolase
CH53_RS20975	COG0583	DNA-binding transcription factor activity
CH53_RS20985	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CH53_RS20990	COG1917	Cupin 2, conserved barrel domain protein
CH53_RS21000	COG1028	Short-chain dehydrogenase reductase Sdr
CH53_RS21010	COG1175	transmembrane transport
CH53_RS21015	COG0395	ABC-type sugar transport system, permease component
CH53_RS21020	COG3842	ATPase activity
CH53_RS21030	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CH53_RS21035	COG1988	membrane-bound metal-dependent
CH53_RS21040	COG1823	symporter activity
CH53_RS21045	COG3023	N-Acetylmuramoyl-L-alanine amidase
CH53_RS21055	COG0823	Involved in the tonB-independent uptake of proteins
CH53_RS21060	COG2814	Major facilitator Superfamily
CH53_RS21065	COG0501	Belongs to the peptidase M48B family
CH53_RS21070	COG0793	Belongs to the peptidase S41A family
CH53_RS21080	COG1956	GAF domain-containing protein
CH53_RS21085	COG2995	paraquat-inducible protein a
CH53_RS21090	COG3008	intermembrane lipid transfer
CH53_RS21100	COG2814	Major facilitator Superfamily
CH53_RS21105	COG3706	GGDEF domain
CH53_RS21105	COG2203	Gaf domain
CH53_RS21105	COG5001	Diguanylate cyclase
CH53_RS21105	COG4251	negative regulation of phosphorylation
CH53_RS21135	COG0625	glutathione transferase activity
CH53_RS21155	COG0697	spore germination
CH53_RS21165	COG1187	pseudouridine synthase activity
CH53_RS21170	COG0668	transmembrane transport
CH53_RS21205	COG4943	cyclic-guanylate-specific phosphodiesterase activity
CH53_RS21290	COG0326	Molecular chaperone. Has ATPase activity
CH53_RS21350	COG1276	copper resistance
CH53_RS21355	COG2372	response to copper ion
CH53_RS21360	COG1528	Iron-storage protein
CH53_RS21375	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CH53_RS21380	COG1770	oligopeptidase
CH53_RS21390	COG3097	Belongs to the UPF0267 family
CH53_RS21395	COG3141	response to X-ray
CH53_RS21400	COG0513	Belongs to the DEAD box helicase family
CH53_RS21405	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
CH53_RS21410	COG3140	Belongs to the UPF0181 family
CH53_RS21420	COG0494	nUDIX hydrolase
CH53_RS21425	COG1760	l-serine dehydratase
CH53_RS21430	COG1253	flavin adenine dinucleotide binding
CH53_RS21435	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH53_RS21435	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CH53_RS21440	COG3715	PTS system
CH53_RS21445	COG3716	PTS system mannose fructose sorbose family IID component
CH53_RS21450	COG4811	Protein of unknown function (DUF986)
CH53_RS21455	COG1971	Probably functions as a manganese efflux pump
CH53_RS21465	COG5001	Diguanylate cyclase
CH53_RS21465	COG5002	protein histidine kinase activity
CH53_RS21465	COG3447	MASE1 domain protein
CH53_RS21475	COG2226	methyltransferase
CH53_RS21480	COG0768	penicillin binding
CH53_RS21485	COG1496	oxidoreductase activity
CH53_RS21505	COG1113	amino acid transport
CH53_RS21540	COG2207	Transcriptional regulator
CH53_RS21560	COG1132	(ABC) transporter
CH53_RS21570	COG2203	Gaf domain
CH53_RS21570	COG4251	negative regulation of phosphorylation
CH53_RS21570	COG3706	GGDEF domain
CH53_RS21570	COG5001	Diguanylate cyclase
CH53_RS21585	COG3755	Protein conserved in bacteria
CH53_RS21595	COG0697	spore germination
CH53_RS21605	COG1733	regulation of RNA biosynthetic process
CH53_RS21610	COG0702	epimerase
CH53_RS21615	COG2873	o-acetylhomoserine
CH53_RS21625	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CH53_RS21635	COG0840	transmembrane signaling receptor activity
CH53_RS21640	COG3397	chitin binding
CH53_RS21660	COG0538	isocitrate dehydrogenase activity
CH53_RS21665	COG1187	pseudouridine synthase activity
CH53_RS21675	COG0482	sulfurtransferase activity
CH53_RS21680	COG2915	High frequency lysogenization protein hflD homolog
CH53_RS21685	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CH53_RS21695	COG0745	RESPONSE REGULATOR receiver
CH53_RS21705	COG2850	peptidyl-arginine hydroxylation
CH53_RS21720	COG1940	carbohydrate kinase activity
CH53_RS21725	COG4591	ABC-type transport system involved in lipoprotein release permease component
CH53_RS21735	COG4591	ABC-type transport system involved in lipoprotein release permease component
CH53_RS21740	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CH53_RS21745	COG3134	Outer membrane lipoprotein
CH53_RS21750	COG1252	NADH dehydrogenase
CH53_RS21755	COG3150	esterase
CH53_RS21770	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
CH53_RS21775	COG5633	Lipoprotein
CH53_RS21780	COG0537	adenosine 5'-monophosphoramidase activity
CH53_RS21790	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CH53_RS21790	COG1263	PTS System
CH53_RS21795	COG0084	hydrolase, TatD family'
CH53_RS21815	COG4943	cyclic-guanylate-specific phosphodiesterase activity
CH53_RS21925	COG2197	response regulator
CH53_RS21940	COG1674	ftsk spoiiie
CH53_RS21965	COG2755	lipolytic protein G-D-S-L family
CH53_RS21965	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups