locus-tag class description HRD68_RS00040 ENOG4108BUD transposase HRD68_RS00050 ENOG4108S1B Periplasmic chaperone protein HRD68_RS00055 ENOG4108D1K outer membrane usher protein HRD68_RS00100 ENOG4108BUD transposase HRD68_RS00130 ENOG4108X73 DNA- binding protein HRD68_RS00135 ENOG4105KF5 hemolysin expression-modulating protein HRD68_RS00170 ENOG4108PCE TRANSFER protein HRD68_RS00175 ENOG4105PDG Type IV secretion system protein VirB8 HRD68_RS00195 ENOG4105KRQ Addiction module toxin, Txe YoeB family HRD68_RS00200 ENOG4105VTW prevent-host-death family HRD68_RS00265 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HRD68_RS00275 ENOG4108BUD transposase HRD68_RS00290 ENOG4108BUD transposase HRD68_RS00310 ENOG4108BUD transposase HRD68_RS00340 ENOG4108BUD transposase HRD68_RS00365 ENOG4108BUD transposase HRD68_RS00370 ENOG4105VT3 DNA binding domain protein, excisionase family HRD68_RS00395 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HRD68_RS00400 ENOG4105KT5 UmuD protein HRD68_RS00480 ENOG41060NJ transcriptional regulator HRD68_RS00490 ENOG4105C87 Aminotransferase class I and II HRD68_RS00660 ENOG4108C33 Resolvase HRD68_RS00715 ENOG4106H6R UPF0380 protein HRD68_RS00805 ENOG4105VDM plasmid maintenance system antidote protein, xre family HRD68_RS00810 ENOG41080ET plasmid maintenance system killer protein HRD68_RS00825 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HRD68_RS00955 ENOG4107QHF type ii secretion system protein e HRD68_RS00970 ENOG4105K5T PilT protein HRD68_RS01120 ENOG4105TKZ Tail Sheath HRD68_RS01225 ENOG4105HRS Antitermination protein HRD68_RS01295 ENOG4105DFP Integrase HRD68_RS01305 ENOG4108Z0T Part of a sulfur-relay system (By similarity) HRD68_RS01310 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 HRD68_RS01320 ENOG4105KT5 UmuD protein HRD68_RS01325 ENOG4105DR4 Methyltransferase HRD68_RS01330 ENOG4105GSS Involved in the degradation of certain denaturated proteins, including DnaA, during heat shock stress (By similarity) HRD68_RS01335 ENOG4105K4P CoA-binding domain protein HRD68_RS01345 ENOG4108Z5K methylglyoxal synthase HRD68_RS01350 ENOG41088T4 Helicase IV HRD68_RS01355 ENOG410901E Membrane HRD68_RS01360 ENOG4105EM2 membrane HRD68_RS01365 ENOG4108RZ1 DNA transformation protein HRD68_RS01370 ENOG4108ZD2 Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division (By similarity) HRD68_RS01380 ENOG4108R9Q Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain (By similarity) HRD68_RS01385 ENOG4105DAN ATP-dependent protease HRD68_RS01390 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) HRD68_RS01400 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HRD68_RS01405 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) HRD68_RS01410 ENOG4108Q2G (LipO)protein HRD68_RS01415 ENOG4105DY2 Paraquat-inducible protein b HRD68_RS01420 ENOG4105F1S paraquat-inducible protein a HRD68_RS01425 ENOG4105C5H ABC transporter HRD68_RS01430 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) HRD68_RS01435 ENOG4105QVC MOSC domain-containing protein HRD68_RS01440 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) HRD68_RS01445 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) HRD68_RS01450 ENOG4105CD8 aminopeptidase N HRD68_RS01455 ENOG4107RH7 Nicotinate phosphoribosyltransferase HRD68_RS01460 ENOG4105C5S asparaginyl-tRNA synthetase HRD68_RS01470 ENOG4105CGF Aromatic amino acid aminotransferase HRD68_RS01475 ENOG4105BZU Histidine kinase HRD68_RS01480 ENOG4105C5X domain protein HRD68_RS01485 ENOG4105EAQ (twin-arginine translocation) pathway signal HRD68_RS01490 ENOG4105DIT ErfK YbiS YcfS YnhG family protein HRD68_RS01505 ENOG4105GHU Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity) HRD68_RS01510 ENOG4106371 Methyltransferase HRD68_RS01515 ENOG4107S90 membrAne HRD68_RS01520 ENOG4107VR7 transferase activity, transferring phosphorus-containing groups HRD68_RS01530 ENOG4105W49 UPF0434 protein HRD68_RS01535 ENOG4105VEQ Cold shock protein HRD68_RS01540 ENOG4105E32 cytoplasmic protein HRD68_RS01560 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) HRD68_RS01565 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) HRD68_RS01575 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase HRD68_RS01585 ENOG4107VMU Membrane HRD68_RS01590 ENOG4105HDK L-asparaginase HRD68_RS01595 ENOG4105DDY UPF0142 protein ycaO HRD68_RS01600 ENOG4105TMB Formate nitrite transporter HRD68_RS01605 ENOG4105C6N Formate acetyltransferase HRD68_RS01610 ENOG4105F1A Pyruvate formate-lyase HRD68_RS01615 ENOG4108ISG Major Facilitator HRD68_RS01620 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) HRD68_RS01625 ENOG4105D1H recombination factor protein RarA HRD68_RS01630 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) HRD68_RS01635 ENOG4105CNU cell division protein FtsK HRD68_RS01640 ENOG4105EW9 transcriptional regulator AsnC family HRD68_RS01645 ENOG4105C3M thioredoxin reductase HRD68_RS01650 ENOG4108JJ9 ABC, transporter HRD68_RS01655 ENOG4108JJ8 (ABC) transporter HRD68_RS01660 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) HRD68_RS01670 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HRD68_RS01675 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) HRD68_RS01680 ENOG4105VEQ Cold shock protein HRD68_RS01690 ENOG4105DJY efflux transporter, rnd family, mfp subunit HRD68_RS01695 ENOG4108MJ5 VirK protein HRD68_RS01700 ENOG4105CPB ATP-dependent endonuclease of the OLD family HRD68_RS01705 ENOG4105DWU Membrane HRD68_RS01710 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) HRD68_RS01715 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HRD68_RS01720 ENOG4105C7K acetolactate synthase HRD68_RS01730 ENOG4105C5W Aldolase HRD68_RS01735 ENOG4105CGD Nad-dependent epimerase dehydratase HRD68_RS01740 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase HRD68_RS01745 ENOG41064MM (LipO)protein HRD68_RS01750 ENOG4105G7T Catalyzes the Claisen rearrangement of chorismate to prephenate (By similarity) HRD68_RS01755 ENOG4105E5Z arginine transporter ATP-binding subunit HRD68_RS01760 ENOG4106PMH Extracellular solute-binding protein family 3 HRD68_RS01765 ENOG4105GBT ABC transporter HRD68_RS01770 ENOG4105DMR ABC, transporter HRD68_RS01775 ENOG4106TNF Periplasmic binding protein HRD68_RS01790 ENOG4105D38 putrescine abc transporter HRD68_RS01795 ENOG4105F38 ABC transporter, permease HRD68_RS01800 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HRD68_RS01805 ENOG4107RUE extracellular solute-binding protein family 1 HRD68_RS01810 ENOG4108RMJ sensory transduction regulator HRD68_RS01815 ENOG4105X20 member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress HRD68_RS01820 ENOG41090BQ Glutaredoxin HRD68_RS01825 ENOG4105D0C transport protein HRD68_RS01840 ENOG4105DNE Transposase HRD68_RS01850 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase HRD68_RS01855 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) HRD68_RS01860 ENOG4107FB0 transcriptional regulator DeoR family HRD68_RS01865 ENOG4105C44 Serine transporter HRD68_RS01870 ENOG4105EJQ L-serine dehydratase HRD68_RS01875 ENOG4105DZ1 carboxypeptidase HRD68_RS01885 ENOG4105C28 cystathionine HRD68_RS01900 ENOG4108UMI ABC transporter, permease HRD68_RS01910 ENOG4105D01 (LipO)protein HRD68_RS01925 ENOG4108TGY Glutathione S-transferase HRD68_RS01930 ENOG4105D05 Receptor HRD68_RS01935 ENOG4108IQI permease HRD68_RS01940 ENOG4105DUM transcriptional regulator, lysR family HRD68_RS01950 ENOG4105HMI Membrane HRD68_RS01955 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) HRD68_RS01960 ENOG4105DM4 PTS System HRD68_RS01965 ENOG4105DE4 1-phosphofructokinase HRD68_RS01970 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein HRD68_RS01980 ENOG4105KRS Proteinase inhibitor HRD68_RS01990 ENOG4105FUQ Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) HRD68_RS02000 ENOG4105DEI Mannitol dehydrogenase HRD68_RS02005 ENOG4107YCY Transcriptional regulator HRD68_RS02010 ENOG4105CKI cobalamin synthesis protein HRD68_RS02015 ENOG41076MN Phosphoesterase, PA-phosphatase related HRD68_RS02020 ENOG4107TT5 NLP P60 protein HRD68_RS02025 ENOG4105CXC rtn protein HRD68_RS02030 ENOG4105E43 Extracellular solute-binding protein, family 5 HRD68_RS02035 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component HRD68_RS02040 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component HRD68_RS02045 ENOG4108JQ5 ABC transporter HRD68_RS02050 ENOG4105HG6 HRD68_RS02055 ENOG4105C2C drug resistance transporter, Bcr CflA HRD68_RS02060 ENOG4105I08 Pseudouridine synthase HRD68_RS02065 ENOG4105CFI type iii restriction protein res subunit HRD68_RS02075 ENOG4106V8H Nucleoid-associated protein HRD68_RS02080 ENOG4105PAN UPF0352 protein HRD68_RS02085 ENOG4105E68 Sulfatase HRD68_RS02105 ENOG410643X FIMH SUBUNIT MANNOSE-sensitive type 1 fimbrial adhesin HRD68_RS02110 ENOG4108T65 Fimbrial HRD68_RS02115 ENOG4108SQA Fimbrial HRD68_RS02125 ENOG4108NAE Fimbrial chaperone protein HRD68_RS02130 ENOG4108RQP Major type 1 subunit fimbrin HRD68_RS02135 ENOG4105CS2 ec 3.2.1.21 HRD68_RS02140 ENOG4105C5Y PTS System HRD68_RS02145 ENOG4108Q3X Transcriptional regulator HRD68_RS02165 ENOG4108VEV chaperone HRD68_RS02175 ENOG4105Y50 Virulence Protein HRD68_RS02185 ENOG4105C8Q Methyl-accepting chemotaxis HRD68_RS02195 ENOG4105CT4 transporter HRD68_RS02200 ENOG4107R6D beta-lactam binding protein AmpH HRD68_RS02215 ENOG4105FCK Membrane HRD68_RS02220 ENOG4107QZV Type I secretion membrane fusion protein HRD68_RS02225 ENOG4105BZ1 (ABC) transporter HRD68_RS02240 ENOG4106UW1 Major Facilitator superfamily HRD68_RS02245 ENOG4105E3G Phosphotransfer intermediate protein in two-component regulatory system with RcsBC HRD68_RS02250 ENOG41068CG regulatoR HRD68_RS02255 ENOG4105BZU Histidine kinase HRD68_RS02260 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HRD68_RS02270 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HRD68_RS02275 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HRD68_RS02280 ENOG4105XPH Ferredoxin HRD68_RS02285 ENOG4108QSZ General inhibitor of pancreatic serine proteases inhibits chymotrypsin, trypsin, elastases, factor X, kallikrein as well as a variety of other proteases (By similarity) HRD68_RS02295 ENOG4105E0U tyrosine-specific transport protein HRD68_RS02300 ENOG4108UII YfaZ family HRD68_RS02305 ENOG4105CH6 catalase HRD68_RS02310 ENOG4105CEY Amp-dependent synthetase and ligase HRD68_RS02315 ENOG4105DNI Converts SHCHC to OSB (By similarity) HRD68_RS02320 ENOG4108IPT Naphthoate synthase HRD68_RS02330 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) HRD68_RS02335 ENOG4105E4F Isochorismate synthase HRD68_RS02345 ENOG4105TNS Conserved Protein HRD68_RS02350 ENOG4105C01 Dihydroxy-acid dehydratase HRD68_RS02355 ENOG41090KN UPF0303 protein HRD68_RS02365 ENOG4105C5I Dehydrogenase HRD68_RS02370 ENOG4105K2J Transcriptional regulator HRD68_RS02375 ENOG4105CHR reductase HRD68_RS02380 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family HRD68_RS02385 ENOG4108R66 Conserved Protein HRD68_RS02390 ENOG4108UQ5 membrane protein YcdZ HRD68_RS02405 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HRD68_RS02410 ENOG4105C8S subunit m HRD68_RS02415 ENOG4105D65 subunit l HRD68_RS02420 ENOG41080EA NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HRD68_RS02425 ENOG4107UFS subunit j HRD68_RS02430 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HRD68_RS02435 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) HRD68_RS02440 ENOG4108IEH NADH dehydrogenase subunit g HRD68_RS02445 ENOG4107QIZ NADH dehydrogenase HRD68_RS02450 ENOG4105GKE subunit e HRD68_RS02455 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HRD68_RS02460 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HRD68_RS02465 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain HRD68_RS02470 ENOG4107NQ8 LysR family Transcriptional regulator HRD68_RS02480 ENOG4105CHM Aminotransferase HRD68_RS02485 ENOG4105DK2 UPF0207 protein HRD68_RS02490 ENOG4107QWE )-transporter HRD68_RS02500 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 HRD68_RS02505 ENOG4105XWI UPF0304 protein HRD68_RS02510 ENOG4105PQ6 UPF0208 membrane protein HRD68_RS02520 ENOG4105C6K Malic enzyme HRD68_RS02525 ENOG4107P2S Transcriptional regulator HRD68_RS02530 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia HRD68_RS02540 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC HRD68_RS02550 ENOG4105E0C molybdate abc transporter HRD68_RS02555 ENOG4105Y50 Virulence Protein HRD68_RS02585 ENOG4105Y9F tail fiber protein HRD68_RS02590 ENOG4105Y0G tail protein HRD68_RS02595 ENOG4108T86 baseplate J family protein HRD68_RS02640 ENOG4105TKZ Tail Sheath HRD68_RS02690 ENOG4105CAR Terminase, large subunit HRD68_RS02735 ENOG4105CDU Replicative dna helicase HRD68_RS02740 ENOG4106CVF DNA replication protein HRD68_RS02880 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein HRD68_RS02890 ENOG4105F4R Transcriptional regulator mode HRD68_RS02895 ENOG4105DKW ABC transporter HRD68_RS02905 ENOG4105CMR udp-glucose 4-epimerase HRD68_RS02910 ENOG4105F0Z galactose-1-phosphate uridylyltransferase HRD68_RS02915 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) HRD68_RS02920 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) HRD68_RS02930 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HRD68_RS02935 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HRD68_RS02940 ENOG4105PGM cation diffusion facilitator family transporter HRD68_RS02945 ENOG4106Z1T Nicotinamide Mononucleotide Transporter HRD68_RS02950 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) HRD68_RS02980 ENOG4105UFD tol-pal system protein YbgF HRD68_RS02985 ENOG4105KCK Peptidoglycan-associated lipoprotein HRD68_RS02990 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) HRD68_RS02995 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA HRD68_RS02995 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA HRD68_RS03005 ENOG4105E02 MotA TolQ exbB proton channel HRD68_RS03010 ENOG4107YD3 Thioesterase HRD68_RS03015 ENOG4105KJB cyd operon protein YbgE HRD68_RS03025 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HRD68_RS03030 ENOG4105C4M (Ubiquinol oxidase) subunit I HRD68_RS03035 ENOG4105CGH 5'-nucleotidase HRD68_RS03040 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha HRD68_RS03050 ENOG4105C7S Dehydrogenase HRD68_RS03055 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 HRD68_RS03060 ENOG4105E33 succinate dehydrogenase HRD68_RS03070 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein HRD68_RS03075 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit HRD68_RS03080 ENOG4105BZN citrate synthase HRD68_RS03100 ENOG4105E7W lamb ycsf family protein HRD68_RS03105 ENOG4107R7A Allophanate hydrolase subunit 2 HRD68_RS03110 ENOG4105P4J Allophanate hydrolase, subunit 1 HRD68_RS03115 ENOG4107QNR UPF0135 protein HRD68_RS03120 ENOG4107RF4 Phosphodiesterase HRD68_RS03125 ENOG4105CVP deoxyribo-dipyrimidine photolyase HRD68_RS03130 ENOG4107SEY Conserved Protein HRD68_RS03135 ENOG4105XIQ Protein of unknown function (DUF2517) HRD68_RS03145 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) HRD68_RS03150 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) HRD68_RS03155 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) HRD68_RS03160 ENOG4105C08 Histidine kinase HRD68_RS03165 ENOG4105EEX Two component transcriptional regulator (Winged helix family HRD68_RS03175 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 HRD68_RS03185 ENOG4105EV9 Alpha Beta Hydrolase HRD68_RS03190 ENOG4105NNH LexA regulated protein HRD68_RS03195 ENOG4105C8Q Methyl-accepting chemotaxis HRD68_RS03200 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) HRD68_RS03205 ENOG41090R7 Ferric uptake HRD68_RS03220 ENOG4105GX6 (LipO)protein HRD68_RS03230 ENOG4105CX6 glutaminyL-tRNA synthetase HRD68_RS03235 ENOG4105CI1 PTS System HRD68_RS03245 ENOG4105CE4 GlcNAc 6-P deacetylase HRD68_RS03250 ENOG4105E2R ROK family HRD68_RS03255 ENOG4105D4U had-superfamily hydrolase, subfamily iia HRD68_RS03260 ENOG4105CAQ asparagine synthetase HRD68_RS03295 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family HRD68_RS03300 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) HRD68_RS03305 ENOG4105C9A Phoh family HRD68_RS03310 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) HRD68_RS03315 ENOG4108JU5 Magnesium and cobalt efflux protein HRD68_RS03320 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) HRD68_RS03330 ENOG4107RP9 extracellular solute-binding protein, family 3 HRD68_RS03335 ENOG4105EAD ABC transporter HRD68_RS03340 ENOG4105DRP amino acid AbC transporter HRD68_RS03345 ENOG4105CDA abc transporter atp-binding protein HRD68_RS03350 ENOG4107PAI alpha helical protein HRD68_RS03360 ENOG4108U2H Rare lipoprotein B HRD68_RS03365 ENOG4105DJF DNA polymerase III, delta' subunit HRD68_RS03370 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) HRD68_RS03375 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) HRD68_RS03385 ENOG4105CJN penicillin-binding protein HRD68_RS03390 ENOG4105CNI cell division protein FtsW HRD68_RS03395 ENOG4105K6T rare lipoprotein A HRD68_RS03400 ENOG4105DZ1 carboxypeptidase HRD68_RS03405 ENOG4108Z43 UPF0250 protein HRD68_RS03410 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) HRD68_RS03415 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) HRD68_RS03420 ENOG410607N Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatE shares overlapping functions with TatA (By similarity) HRD68_RS03425 ENOG4105BZU Histidine kinase HRD68_RS03445 ENOG4108N8T regulatoR HRD68_RS03455 ENOG4108R1E Serine threonine protein phosphatase 1 HRD68_RS03470 ENOG4108JJ7 ABC transporter HRD68_RS03480 ENOG4105EZE Cupin 4 family protein HRD68_RS03490 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase HRD68_RS03495 ENOG4107QPK )-transporter HRD68_RS03505 ENOG4108Q2J Inner membrane protein YebE HRD68_RS03515 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) HRD68_RS03520 ENOG4105D7K pfkb domain protein HRD68_RS03525 ENOG4108HKT sucrose-6-phosphate hydrolase HRD68_RS03530 ENOG4106NDP Transcriptional regulator HRD68_RS03545 ENOG4105DD7 kinase (PfkB family HRD68_RS03550 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) HRD68_RS03555 ENOG4105D9N nucleoside HRD68_RS03580 ENOG410822N TonB family HRD68_RS03600 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA HRD68_RS03620 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) HRD68_RS03625 ENOG4105WQ3 Rna-binding protein HRD68_RS03645 ENOG4105UGQ Fimbrial HRD68_RS03655 ENOG4108FZ9 Chaperone HRD68_RS03660 ENOG4106PG1 outer membrane usher protein HRD68_RS03680 ENOG4105C8N cysteinyl-tRNA synthetase HRD68_RS03685 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) HRD68_RS03690 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) HRD68_RS03695 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) HRD68_RS03700 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit HRD68_RS03705 ENOG4105CV6 ABC transporter, permease HRD68_RS03710 ENOG4108I0Y (ABC) transporter HRD68_RS03715 ENOG4108UJV acyl-CoA thioesterase i HRD68_RS03720 ENOG4105E1F short-chain dehydrogenase reductase HRD68_RS03725 ENOG4107QR8 Thioredoxin HRD68_RS03730 ENOG4107QX8 SPFH domain, Band 7 family protein HRD68_RS03735 ENOG4105G5H Membrane HRD68_RS03745 ENOG4105C59 p-type ATPase HRD68_RS03750 ENOG4105MBR gumn family HRD68_RS03755 ENOG4108Z66 YbaK ebsC protein HRD68_RS03760 ENOG4105CGH 5'-nucleotidase HRD68_RS03765 ENOG4105EU0 Major facilitator Superfamily HRD68_RS03770 ENOG4105CKD glutathione-regulated potassium-efflux system protein HRD68_RS03775 ENOG4107RE1 Inosine-guanosine kinase HRD68_RS03780 ENOG4108QY5 Ferric enterobactin transport protein HRD68_RS03785 ENOG4105CMR udp-glucose 4-epimerase HRD68_RS03795 ENOG4105DMT epimerase dehydratase HRD68_RS03820 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) HRD68_RS03825 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) HRD68_RS03830 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) HRD68_RS03835 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) HRD68_RS03845 ENOG4107QMP dna polymerase iii subunits gamma and tau HRD68_RS03850 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) HRD68_RS03855 ENOG4105WD1 Membrane HRD68_RS03865 ENOG4106428 Protein of unknown function (DUF2496) HRD68_RS03870 ENOG4105EGS Mechanosensitive ion channel HRD68_RS03875 ENOG41090EX DsrE family HRD68_RS03880 ENOG4107XI7 Tetr family transcriptional regulator HRD68_RS03885 ENOG4105C1P efflux transporter, rnd family, mfp subunit HRD68_RS03890 ENOG4105BZS acriflavin resistance protein HRD68_RS03895 ENOG4105RMW regulation of transcription, DNA-dependent HRD68_RS03900 ENOG4108626 Racemase HRD68_RS03905 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) HRD68_RS03910 ENOG4105NRA 50s ribosomal protein l31 type b HRD68_RS03915 ENOG4105YK5 50S ribosomal protein L36 HRD68_RS03920 ENOG4105DSE periplasmic solute binding protein HRD68_RS03925 ENOG4105CC5 ABC transporter HRD68_RS03930 ENOG4105DIK (ABC) transporter HRD68_RS03940 ENOG4108UKR Biofilm formation regulator YbaJ HRD68_RS03945 ENOG4105KF5 hemolysin expression-modulating protein HRD68_RS03965 ENOG41080UX Methyltransferase HRD68_RS03970 ENOG4108MNP Glycoprotein polysaccharide metabolism HRD68_RS03975 ENOG4105C29 acyl-CoA thioesterase HRD68_RS03980 ENOG4105BZU Histidine kinase HRD68_RS03985 ENOG4108YZA Nitrogen regulatory protein pii HRD68_RS03990 ENOG4105BZ1 (ABC) transporter HRD68_RS03995 ENOG4105BZ1 (ABC) transporter HRD68_RS04000 ENOG4108XM1 transcriptional regulator AsnC family HRD68_RS04010 ENOG4108AZI Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2- methyl-5-hydroxymethylpyrimidine phosphate (HMP-P) (By similarity) HRD68_RS04015 ENOG4108NFA extracellular solute-binding protein HRD68_RS04020 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) HRD68_RS04025 ENOG4108TGP Thioesterase superfamily protein HRD68_RS04030 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein HRD68_RS04035 ENOG4105EIN peptidylprolyl cis-trans isomerase HRD68_RS04040 ENOG4105K70 DNA-binding protein HRD68_RS04045 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) HRD68_RS04050 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) HRD68_RS04055 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HRD68_RS04060 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation HRD68_RS04065 ENOG4105M85 Bola protein HRD68_RS04070 ENOG4105IEY (LipO)protein HRD68_RS04075 ENOG4105EYM Major Facilitator superfamily HRD68_RS04080 ENOG4108NFH Sugar hydrolase HRD68_RS04085 ENOG4105E2S oxidase) subunit II HRD68_RS04090 ENOG4105BZ9 Cytochrome C oxidase, subunit I HRD68_RS04095 ENOG4105CCU oxidase (Subunit III) HRD68_RS04100 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) HRD68_RS04105 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) HRD68_RS04110 ENOG4107RDB Major Facilitator HRD68_RS04115 ENOG4108VPT UPF0234 protein HRD68_RS04120 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) HRD68_RS04125 ENOG4107S0N DJ-1 family HRD68_RS04130 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) HRD68_RS04140 ENOG4105CTB Polyprenyl synthetase HRD68_RS04145 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) HRD68_RS04150 ENOG4108ZAI phosphatidylglycerophosphatase a HRD68_RS04155 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) HRD68_RS04170 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) HRD68_RS04175 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) HRD68_RS04185 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HRD68_RS04190 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HRD68_RS04195 ENOG4105VIE preprotein translocase, subunit YajC HRD68_RS04200 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) HRD68_RS04210 ENOG4108ZYK Acyl carrier protein phosphodiesterase HRD68_RS04215 ENOG4105D3R alkyl hydroperoxide reductase HRD68_RS04225 ENOG4105CHR reductase HRD68_RS04230 ENOG4107R28 alpha amylase, catalytic region HRD68_RS04235 ENOG4105C85 amino acid HRD68_RS04240 ENOG4105CWM branched-chain amino acid transport system II carrier protein HRD68_RS04245 ENOG4105DJH phosphate HRD68_RS04250 ENOG4105BZU Histidine kinase HRD68_RS04255 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HRD68_RS04260 ENOG4107RH8 nuclease SbcCD subunit D HRD68_RS04265 ENOG4105EYH Exonuclease HRD68_RS04270 ENOG4105DKQ ROK family HRD68_RS04275 ENOG4105DH7 May be involved in recombination (By similarity) HRD68_RS04280 ENOG4105NBK UPF0345 protein HRD68_RS04285 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) HRD68_RS04300 ENOG4105F2W methyltransferase HRD68_RS04315 ENOG4105E2V Glycosyltransferase 36 HRD68_RS04325 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) HRD68_RS04330 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) HRD68_RS04335 ENOG4108UVK Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32 (By similarity) HRD68_RS04340 ENOG4105V1F Fermentation respiration switch protein HRD68_RS04350 ENOG4105CIN aminoacyl-histidine dipeptidase HRD68_RS04355 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HRD68_RS04370 ENOG4105CJ2 (LipO)protein HRD68_RS04375 ENOG4105D26 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity) HRD68_RS04380 ENOG4108IUB NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) HRD68_RS04385 ENOG4105F5D NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) HRD68_RS04390 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) HRD68_RS04395 ENOG4108J5C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) HRD68_RS04400 ENOG4105DWQ NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) HRD68_RS04405 ENOG4105F7V ErfK ybiS ycfS ynhG family protein HRD68_RS04410 ENOG4105E7A Glutamine amidotransferase HRD68_RS04420 ENOG4107QPN acyl-Coa dehydrogenase HRD68_RS04425 ENOG4106YJS accessory processing protein HRD68_RS04440 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) HRD68_RS04450 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) HRD68_RS04460 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) HRD68_RS04465 ENOG4105CHM Aminotransferase HRD68_RS04475 ENOG4105C5R Aminotransferase HRD68_RS04480 ENOG4105EQ0 Major Facilitator superfamily HRD68_RS04485 ENOG4108UMN azlc family HRD68_RS04490 ENOG4105ZED uncharacterized protein ygaH HRD68_RS04495 ENOG4105NTK Transcriptional repressor Mpra HRD68_RS04505 ENOG4105CW7 secretion protein, HlyD family HRD68_RS04510 ENOG4105C0R drug resistance transporter emrb qaca subfamily HRD68_RS04515 ENOG4105EIB trna rrna methyltransferase HRD68_RS04520 ENOG4105K63 Thioredoxin HRD68_RS04525 ENOG4106IUH DTW domain containing protein HRD68_RS04530 ENOG4105CD5 CoA-binding domain protein HRD68_RS04535 ENOG4105JIM Phosphatidylserine synthase HRD68_RS04565 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HRD68_RS04570 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase HRD68_RS04575 ENOG4105C34 Pseudouridine synthase HRD68_RS04580 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane HRD68_RS04585 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA HRD68_RS04590 ENOG4105CQC Prephenate dehydratase HRD68_RS04595 ENOG4105EHE chorismate mutase- prephenate dehydrogenase HRD68_RS04600 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HRD68_RS04605 ENOG4108NEV two component transcriptional regulator, LytTR family HRD68_RS04610 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HRD68_RS04615 ENOG4108NE3 Salt-induced outer membrane protein HRD68_RS04620 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) HRD68_RS04630 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) HRD68_RS04640 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY HRD68_RS04645 ENOG4106KVJ cytochrome C assembly protein HRD68_RS04650 ENOG4108JU6 CBS domain protein HRD68_RS04655 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) HRD68_RS04660 ENOG4105D9M gamma-glutamylcysteine synthetase HRD68_RS04665 ENOG4105W39 Membrane HRD68_RS04670 ENOG4107VXZ Hydrolase HRD68_RS04700 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HRD68_RS04705 ENOG4105Y3E Modulates RecA activity (By similarity) HRD68_RS04710 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) HRD68_RS04735 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HRD68_RS04740 ENOG4108IUS Transketolase HRD68_RS04745 ENOG4108HHA Transketolase HRD68_RS04750 ENOG4105CNN ABC, transporter HRD68_RS04755 ENOG4105C2J ABC transporter HRD68_RS04780 ENOG4108NEM leader-binding protein dmsD HRD68_RS04785 ENOG4107KGK dmso reductase anchor subunit HRD68_RS04790 ENOG4105QAX Iron-sulfur HRD68_RS04795 ENOG4107QY8 reductase HRD68_RS04800 ENOG4105C0A alcohol dehydrogenase HRD68_RS04805 ENOG4107W7X Aldolase HRD68_RS04810 ENOG4105EDR glucose galactose transporter HRD68_RS04820 ENOG4105CMG Carbohydrate kinase HRD68_RS04830 ENOG4107EDW L-fucose operon activator HRD68_RS04835 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase HRD68_RS04840 ENOG4105E98 transcriptional regulator DeoR family HRD68_RS04850 ENOG4105C2J ABC transporter HRD68_RS04855 ENOG4105CNN ABC, transporter HRD68_RS04865 ENOG41064BZ L-xylulose 5-phosphate 3-epimerase HRD68_RS04870 ENOG4105CMG Carbohydrate kinase HRD68_RS04875 ENOG4107GFK fumarate HRD68_RS04885 ENOG4105C32 Amino acid ABC transporter (Permease) HRD68_RS04890 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HRD68_RS04895 ENOG4108IUZ ABC transporter HRD68_RS04900 ENOG4108IV0 ABC, transporter HRD68_RS04925 ENOG4105DKT Transcriptional regulator HRD68_RS04930 ENOG4108XCU pts system HRD68_RS04935 ENOG4105KPI PTS system sorbose subfamily IIB component HRD68_RS04940 ENOG4105ETZ PTS System HRD68_RS04945 ENOG4105F3R pts system mannose fructose sorbose family iid HRD68_RS04950 ENOG4105DXH Alcohol dehydrogenase zinc-binding domain protein HRD68_RS04955 ENOG4105YVS arsR family transcriptional regulator HRD68_RS04960 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) HRD68_RS04975 ENOG4105CE7 Amidase, hydantoinase carbamoylase family HRD68_RS04980 ENOG4105CDA abc transporter atp-binding protein HRD68_RS04985 ENOG4105E5Q amino acid AbC transporter HRD68_RS04990 ENOG4105E5Q amino acid AbC transporter HRD68_RS04995 ENOG4105EAB amino acid AbC transporter HRD68_RS05000 ENOG4105BZC d-serine deaminase HRD68_RS05005 ENOG4105C6Z Gluconate HRD68_RS05010 ENOG4105W8I Transcriptional regulator HRD68_RS05015 ENOG4108JQ7 (ABC) transporter HRD68_RS05025 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HRD68_RS05030 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HRD68_RS05035 ENOG4105DEF Extracellular solute-binding protein, family 5 HRD68_RS05040 ENOG4105CXK mandelate racemase muconate lactonizing HRD68_RS05045 ENOG4105CIH Imidazole acetol-phosphate transaminase HRD68_RS05050 ENOG4105F87 Dehydratase HRD68_RS05060 ENOG4105CHR reductase HRD68_RS05075 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HRD68_RS05080 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HRD68_RS05085 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HRD68_RS05090 ENOG4105DJY efflux transporter, rnd family, mfp subunit HRD68_RS05095 ENOG4108JJA ABC, transporter HRD68_RS05120 ENOG4105H8W Fimbrial protein HRD68_RS05125 ENOG4105NEV Fimbrial HRD68_RS05140 ENOG4108FZ9 Chaperone HRD68_RS05145 ENOG4106PG1 outer membrane usher protein HRD68_RS05170 ENOG4105EHZ conserved protein UCP016719 HRD68_RS05180 ENOG4105D17 glycoside hydrolase, family 3 domain protein HRD68_RS05185 ENOG4108PSC Represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc). Binds to two adjacent inverted repeats within the operator region. MurNAc 6-phosphate, the substrate of MurQ, is the specific inducer that weakens binding of MurR to the operator (By similarity) HRD68_RS05190 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate HRD68_RS05195 ENOG4105C5Y PTS System HRD68_RS05205 ENOG4105CW0 outer membrane usher protein HRD68_RS05210 ENOG4108VCD Chaperone HRD68_RS05215 ENOG4108VCD Chaperone HRD68_RS05225 ENOG4108VCD Chaperone HRD68_RS05240 ENOG4105C28 cystathionine HRD68_RS05250 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) HRD68_RS05255 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HRD68_RS05260 ENOG4108K5P (LipO)protein HRD68_RS05265 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) HRD68_RS05270 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) HRD68_RS05275 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) HRD68_RS05280 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) HRD68_RS05290 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) HRD68_RS05295 ENOG4106PMH Extracellular solute-binding protein family 3 HRD68_RS05300 ENOG4105DRP amino acid AbC transporter HRD68_RS05310 ENOG4105N0Z inner membrane protein ygbE HRD68_RS05315 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) HRD68_RS05320 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) HRD68_RS05325 ENOG4105C11 sulfate adenylyltransferase), subunit 2 HRD68_RS05330 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HRD68_RS05335 ENOG4108MXK alkaline phosphatase isozyme conversion HRD68_RS05340 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) HRD68_RS05345 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) HRD68_RS05350 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) HRD68_RS05355 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase HRD68_RS05360 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) HRD68_RS05375 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) HRD68_RS05380 ENOG4105DXN mazG family HRD68_RS05385 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HRD68_RS05390 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) HRD68_RS05395 ENOG4105BZU Histidine kinase HRD68_RS05400 ENOG4105C0H protease HRD68_RS05405 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein HRD68_RS05410 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) HRD68_RS05420 ENOG4105EN6 Membrane HRD68_RS05430 ENOG4108YX9 iron--sulfur cluster insertion protein erpA HRD68_RS05440 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase HRD68_RS05445 ENOG4105S6R Iron-hydroxamate transporter permease subunit HRD68_RS05450 ENOG4105J76 Periplasmic binding protein HRD68_RS05455 ENOG4105E0A ABC, transporter HRD68_RS05460 ENOG4105BZ4 penicillin-binding protein HRD68_RS05465 ENOG4105CQ7 ATP-dependent helicase HRD68_RS05470 ENOG4107XID 2'-5' rna ligase HRD68_RS05480 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters HRD68_RS05490 ENOG4105DJ0 Poly(A) Polymerase HRD68_RS05495 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase HRD68_RS05500 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) HRD68_RS05505 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) HRD68_RS05510 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) HRD68_RS05515 ENOG4107BJW polysaccharide deacetylase HRD68_RS05520 ENOG4105E3A (ABC) transporter HRD68_RS05525 ENOG4105DA5 (ABC) transporter HRD68_RS05530 ENOG41077A9 carbonic anhydrase HRD68_RS05535 ENOG4108UGV hypoxanthine phosphoribosyltransferase HRD68_RS05545 ENOG4105E3B Multicopper oxidase HRD68_RS05550 ENOG4108ZRK uncharacterized protein yacC HRD68_RS05555 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) HRD68_RS05570 ENOG4108ZIG UPF0231 protein HRD68_RS05575 ENOG4107QIJ Aconitate hydratase 2 HRD68_RS05580 ENOG4107RNH Outer membrane receptor FepA HRD68_RS05590 ENOG4107QN2 dihydrolipoyl dehydrogenase HRD68_RS05595 ENOG4107QSN dihydrolipoamide acetyltransferase HRD68_RS05600 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) HRD68_RS05605 ENOG41073TP transcriptional regulator HRD68_RS05610 ENOG4105C85 amino acid HRD68_RS05620 ENOG4106A72 regulatory protein AmpE HRD68_RS05625 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase HRD68_RS05630 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase HRD68_RS05635 ENOG4108ZUW Major pilin subunit HRD68_RS05640 ENOG4107QHF type ii secretion system protein e HRD68_RS05645 ENOG4105D7Q type ii secretion system HRD68_RS05650 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HRD68_RS05665 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) HRD68_RS05670 ENOG4105M6F mutator MutT protein HRD68_RS05675 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving HRD68_RS05680 ENOG4108SR7 Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation (By similarity) HRD68_RS05695 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) HRD68_RS05700 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) HRD68_RS05705 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) HRD68_RS05715 ENOG4105DFU Cell wall formation (By similarity) HRD68_RS05720 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) HRD68_RS05725 ENOG4105CNI cell division protein FtsW HRD68_RS05735 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) HRD68_RS05740 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) HRD68_RS05745 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) HRD68_RS05750 ENOG4105CJN penicillin-binding protein HRD68_RS05755 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) HRD68_RS05760 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) HRD68_RS05775 ENOG4107B7Y DNA-binding transcriptional regulator FruR HRD68_RS05780 ENOG4108ZP8 Acetolactate synthase small subunit HRD68_RS05785 ENOG4105C7K acetolactate synthase HRD68_RS05790 ENOG4108IQE Amp-dependent synthetase and ligase HRD68_RS05795 ENOG41064T2 transcriptional regulator, lysR family HRD68_RS05810 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HRD68_RS05815 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HRD68_RS05830 ENOG4105C0F tryptophanase EC 4.1.99.1 HRD68_RS05835 ENOG4105CIC tryptophan-specific transport protein HRD68_RS05840 ENOG4105S8Q sugar efflux transporter HRD68_RS05850 ENOG4105F1A Pyruvate formate-lyase HRD68_RS05855 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) HRD68_RS05860 ENOG4105DP9 ABC transporter HRD68_RS05865 ENOG4106SMU thiamine transporter membrane protein HRD68_RS05870 ENOG4107T0D ABC, transporter HRD68_RS05875 ENOG4108KF1 Membrane HRD68_RS05880 ENOG4105CQ2 DNA polymerase HRD68_RS05890 ENOG4105Q26 Siderophore-interacting protein HRD68_RS05910 ENOG4105DUU IucA IucC family protein HRD68_RS05915 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) HRD68_RS05925 ENOG4105D3G Pseudouridine synthase HRD68_RS05935 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) HRD68_RS05940 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) HRD68_RS05955 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) HRD68_RS05960 ENOG4105NWN ApaG protein HRD68_RS05965 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) HRD68_RS05970 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) HRD68_RS05980 ENOG4105DWK Membrane HRD68_RS05985 ENOG4105N14 lysine exporter protein LysE YggA HRD68_RS05990 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain HRD68_RS06005 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) HRD68_RS06010 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase HRD68_RS06020 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) HRD68_RS06025 ENOG4105DTN riboflavin biosynthesis protein ribF HRD68_RS06045 ENOG41063Z6 transcriptional regulator, lysR family HRD68_RS06050 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) HRD68_RS06060 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) HRD68_RS06070 ENOG4106HK8 GPR1 FUN34 yaaH family protein HRD68_RS06080 ENOG4105CSH Transporter HRD68_RS06085 ENOG4108RIR Molybdenum cofactor biosynthesis protein HRD68_RS06090 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HRD68_RS06095 ENOG4105D1Q UPF0246 protein HRD68_RS06105 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) HRD68_RS06120 ENOG41065U4 response regulator HRD68_RS06125 ENOG4108RH0 Crea protein HRD68_RS06130 ENOG4105UEI Transcriptional Regulator AraC Family HRD68_RS06135 ENOG4105CVJ phosphoglycerate mutase HRD68_RS06140 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HRD68_RS06145 ENOG4105R9M This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity) HRD68_RS06150 ENOG4107SC1 transglycosylase HRD68_RS06165 ENOG4108KHX Diguanylate cyclase HRD68_RS06170 ENOG41090EK ompa motb domain protein HRD68_RS06175 ENOG4105C5H ABC transporter HRD68_RS06210 ENOG4105C0A alcohol dehydrogenase HRD68_RS06225 ENOG4105CIS alcohol dehydrogenase HRD68_RS06230 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase HRD68_RS06235 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) HRD68_RS06240 ENOG4105EAC phosphoserine phosphatase HRD68_RS06245 ENOG41062Z9 Membrane HRD68_RS06250 ENOG4105K4U addiction module toxin, RelE StbE family HRD68_RS06265 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) HRD68_RS06280 ENOG4105D9N nucleoside HRD68_RS06285 ENOG4105EYA deoxyribonuclease HRD68_RS06290 ENOG4108NRW Phospholipase, patatin family HRD68_RS06300 ENOG4105K3G Periplasmic Protein HRD68_RS06305 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) HRD68_RS06310 ENOG4105KEG ribosomal-protein-alanine acetyltransferase HRD68_RS06315 ENOG4108WPU DNA polymerase III subunit psi HRD68_RS06320 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) HRD68_RS06325 ENOG4105CPC Aldo Keto reductase HRD68_RS06350 ENOG4105YBH Protein of unknown function (DUF1435) HRD68_RS06355 ENOG4105BZU Histidine kinase HRD68_RS06360 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family HRD68_RS06370 ENOG4106UW1 Major Facilitator superfamily HRD68_RS06395 ENOG4105VDH Dihydroxyacetone kinase HRD68_RS06400 ENOG4108UTZ Dihydroxyacetone kinase HRD68_RS06405 ENOG4105CMT Dihydroxyacetone kinase HRD68_RS06415 ENOG4105BZS acriflavin resistance protein HRD68_RS06420 ENOG410624X efflux transporter, rnd family, mfp subunit HRD68_RS06425 ENOG4105CEU Arginine dihydrolase HRD68_RS06430 ENOG4105D5Q Arginine ornithine antiporter HRD68_RS06440 ENOG4105DKP glycosyl transferase, family 9 HRD68_RS06445 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) HRD68_RS06450 ENOG4105DKT Transcriptional regulator HRD68_RS06455 ENOG4105C2J ABC transporter HRD68_RS06460 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane HRD68_RS06465 ENOG4105F5R ABC transporter HRD68_RS06475 ENOG41061GT Aldolase HRD68_RS06485 ENOG4105RI1 glycoprotein receptor HRD68_RS06490 ENOG4105CAF HipA N-terminal domain protein HRD68_RS06495 ENOG41061P8 Persistence to inhibition of murein or DNA biosynthesis regulatory protein HRD68_RS06525 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles HRD68_RS06530 ENOG4108X3P Toxic component of a toxin-antitoxin (TA) module. Overexpression results in inhibition of growth in liquid cultures HRD68_RS06535 ENOG4106549 Antirestriction protein HRD68_RS06540 ENOG4106H6R UPF0380 protein HRD68_RS06585 ENOG4105FBQ ATPase associated with various cellular activities aaa_5 HRD68_RS06640 ENOG4108K5H permease YjgP YjgQ family protein HRD68_RS06645 ENOG4108M8S permease YjgP YjgQ family protein HRD68_RS06650 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) HRD68_RS06655 ENOG4105MYG DNA polymerase iii, chi subunit HRD68_RS06665 ENOG4108MJ3 acetyltransferase HRD68_RS06670 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) HRD68_RS06680 ENOG4105XEP YhcH YjgK YiaL family protein HRD68_RS06690 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HRD68_RS06695 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HRD68_RS06700 ENOG4105C3U ABC transporter HRD68_RS06705 ENOG4108JQ7 (ABC) transporter HRD68_RS06720 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase HRD68_RS06725 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) HRD68_RS06740 ENOG4107RJJ Transcriptional regulator HRD68_RS06745 ENOG4105KQZ Phosphonate C-P lyase system protein PhnG HRD68_RS06750 ENOG4105KZ6 phosphonate C-P lyase system protein PhnH HRD68_RS06755 ENOG4105EKV Phosphonate metabolism protein HRD68_RS06760 ENOG4105FT8 Phosphonate metabolism HRD68_RS06765 ENOG4105ENV phosphonate C-P lyase system protein PhnK HRD68_RS06770 ENOG4105HRV phosphonate c-p lyase system protein phnl HRD68_RS06775 ENOG4105FD8 phosphonate metabolism protein PhnM HRD68_RS06780 ENOG4105MFQ Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity) HRD68_RS06785 ENOG4107SA6 carbon-phosphorus lyase complex accessory protein HRD68_RS06790 ENOG4105K4T epimerase HRD68_RS06810 ENOG4105DRS transport system, permease HRD68_RS06830 ENOG4105EY3 heparinase II III family protein HRD68_RS06840 ENOG4105CXN decarboxylase HRD68_RS06845 ENOG4105D5Q Arginine ornithine antiporter HRD68_RS06855 ENOG4108YYD acetyltransferase HRD68_RS06875 ENOG4105CEM UPF0597 protein HRD68_RS06880 ENOG4105C44 Serine transporter HRD68_RS06885 ENOG4105DEN Luciferase family HRD68_RS06890 ENOG4105C1J atp-dependent rna helicase HRD68_RS06905 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) HRD68_RS06915 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) HRD68_RS06920 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) HRD68_RS06930 ENOG4105CHV Transcription elongation factor NusA HRD68_RS06950 ENOG4105NTZ Preprotein translocase subunit SecG HRD68_RS06960 ENOG4105EEI dihydropteroate synthase HRD68_RS06965 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HRD68_RS06970 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) HRD68_RS06975 ENOG4105HBR Rna-binding protein HRD68_RS06985 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase HRD68_RS07000 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control HRD68_RS07005 ENOG4105QYV Membrane HRD68_RS07010 ENOG4105K46 50S ribosomal protein l27 HRD68_RS07020 ENOG4105EAH synthase HRD68_RS07030 ENOG4105HVQ Regulatory factor of maltose metabolism HRD68_RS07050 ENOG4105DFU Cell wall formation (By similarity) HRD68_RS07060 ENOG4105C8Q Methyl-accepting chemotaxis HRD68_RS07065 ENOG4105F0N pyrophosphate phospho-hydrolase HRD68_RS07070 ENOG4108ZHD aig2 family HRD68_RS07075 ENOG4105MA0 exported protein HRD68_RS07085 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) HRD68_RS07090 ENOG4105C37 (CBS) domain HRD68_RS07095 ENOG41061GZ Protein of unknown function (DUF1107) HRD68_RS07100 ENOG4108UUE Transcriptional regulator HRD68_RS07105 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase HRD68_RS07110 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic HRD68_RS07120 ENOG4108V1T peptidylprolyl cis-trans isomerase HRD68_RS07125 ENOG4105FHY Opacity-associated protein A HRD68_RS07135 ENOG4105K9Q Binds to the 23S rRNA (By similarity) HRD68_RS07150 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) HRD68_RS07155 ENOG4105RID UPF0379 protein yhcN HRD68_RS07160 ENOG4108MXZ Esterase HRD68_RS07165 ENOG4105WSB biofilm stress and motility protein A HRD68_RS07170 ENOG4105CSU acyl-Coa dehydrogenase HRD68_RS07175 ENOG4105C2N RNA methyltransferase TrmH family group 3 HRD68_RS07180 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) HRD68_RS07185 ENOG4105KPV Transcriptional regulator HRD68_RS07200 ENOG4105EPW hflc protein HRD68_RS07205 ENOG4107QJR hflk protein HRD68_RS07210 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HRD68_RS07220 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) HRD68_RS07230 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HRD68_RS07235 ENOG4105K8N protein family UPF0079, ATPase HRD68_RS07240 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) HRD68_RS07245 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) HRD68_RS07265 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) HRD68_RS07270 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) HRD68_RS07275 ENOG4105DJ4 phosphatidylserine decarboxylase HRD68_RS07280 ENOG4105EGS Mechanosensitive ion channel HRD68_RS07300 ENOG4108WJH Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) HRD68_RS07305 ENOG4108VP9 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) HRD68_RS07325 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) HRD68_RS07330 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein HRD68_RS07335 ENOG4108ZVF (LipO)protein HRD68_RS07340 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) HRD68_RS07345 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) HRD68_RS07360 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HRD68_RS07370 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) HRD68_RS07375 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) HRD68_RS07380 ENOG4105BZ8 glutamate synthase HRD68_RS07385 ENOG4105BZ8 glutamate synthase HRD68_RS07390 ENOG4105DJB Major Facilitator Superfamily HRD68_RS07395 ENOG4105BZW Glycerate kinase HRD68_RS07400 ENOG4105CTX dehydratase HRD68_RS07405 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR HRD68_RS07410 ENOG4105BZW Glycerate kinase HRD68_RS07415 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HRD68_RS07420 ENOG4105CNV Aldolase HRD68_RS07425 ENOG4108SIC Transcriptional regulator HRD68_RS07435 ENOG4108EX3 reductase HRD68_RS07440 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase HRD68_RS07445 ENOG4105FAW cDP-glucose 4,6-dehydratase HRD68_RS07450 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HRD68_RS07485 ENOG4105D1F ATP-binding protein HRD68_RS07495 ENOG4107EEX Cellulose synthase regulator protein HRD68_RS07500 ENOG4105EJG cellulose synthase HRD68_RS07510 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) HRD68_RS07515 ENOG4105D4P Coproporphyrinogen iii oxidase HRD68_RS07520 ENOG41090JE Utilization Protein HRD68_RS07530 ENOG4107F3C Hemin uptake protein HRD68_RS07535 ENOG4107ENK receptor HRD68_RS07540 ENOG4106QJH hemin transport protein HRD68_RS07545 ENOG4107R4I Periplasmic binding protein HRD68_RS07550 ENOG4105EHG Permease protein HRD68_RS07555 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) HRD68_RS07560 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HRD68_RS07570 ENOG4105E0K tonB-dependent siderophore receptor HRD68_RS07575 ENOG4105EGS Mechanosensitive ion channel HRD68_RS07615 ENOG4108TN6 type iii secretion HRD68_RS07620 ENOG4105U07 type iii secretion HRD68_RS07625 ENOG41075IY surface presentation of antigens protein SpaP HRD68_RS07645 ENOG4108JIR Flagellum-specific ATP synthase HRD68_RS07655 ENOG4108HR8 type iii secretion HRD68_RS07660 ENOG4105X27 type iii secretion HRD68_RS07670 ENOG4108KB1 transcriptional regulator, arac family HRD68_RS07690 ENOG4108RBT type iii secretion HRD68_RS07710 ENOG4105FTC Lytic transglycosylase catalytic HRD68_RS07725 ENOG4105WH1 Two component transcriptional regulator luxr family HRD68_RS07730 ENOG4108FKE two-component system sensor kinase HRD68_RS07770 ENOG4107QHF type ii secretion system protein e HRD68_RS07775 ENOG4105D7Q type ii secretion system HRD68_RS07790 ENOG4105X5Z General secretion pathway protein I HRD68_RS07815 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) HRD68_RS07825 ENOG4108M1A Chitin-binding protein HRD68_RS07835 ENOG4107RAN Peptidase, M16 HRD68_RS07840 ENOG4105CQ0 ABC transporter HRD68_RS07845 ENOG4105PE1 Receptor HRD68_RS07850 ENOG4108S3W Anti-feci sigma factor, fecr HRD68_RS07855 ENOG4108SF5 RNA Polymerase HRD68_RS07870 ENOG4105VDM plasmid maintenance system antidote protein, xre family HRD68_RS07880 ENOG41066VF YeeE YedE family protein HRD68_RS07885 ENOG4108IUF type iii secretion HRD68_RS07890 ENOG4108TN6 type iii secretion HRD68_RS07895 ENOG41083GP type iii secretion HRD68_RS07900 ENOG4108HHI Type III secretion system protein HRD68_RS07920 ENOG4108JIR Flagellum-specific ATP synthase HRD68_RS07930 ENOG4106H1D secretion system apparatus protein HRD68_RS07935 ENOG4105UQF type iii secretion HRD68_RS07990 ENOG4106FZW pathogenicity island effector protein HRD68_RS07995 ENOG4108SZ7 secretion system effector HRD68_RS08005 ENOG4105ZQI secreted protein HRD68_RS08035 ENOG4105BZU Histidine kinase HRD68_RS08045 ENOG4105CK2 sodium dicarboxylate symporter HRD68_RS08050 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HRD68_RS08055 ENOG41062QD Membrane HRD68_RS08060 ENOG4107QN1 sodium solute HRD68_RS08105 ENOG4105C12 Phosphoribosylglycinamide synthetase HRD68_RS08110 ENOG4108T8B Protein of unknown function (DUF1481) HRD68_RS08120 ENOG4105R2J Conserved Protein HRD68_RS08125 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) HRD68_RS08135 ENOG4105E09 nadh pyrophosphatase HRD68_RS08140 ENOG4108ZVW Anti-RNA polymerase sigma 70 factor HRD68_RS08155 ENOG4105D06 uba thif-type nad fad binding protein HRD68_RS08160 ENOG4105WHD thiamine biosynthesis protein ThiS HRD68_RS08170 ENOG4105D41 biosynthesis protein thiH HRD68_RS08175 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HRD68_RS08180 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HRD68_RS08185 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) HRD68_RS08190 ENOG4108VZM 50s ribosomal protein L10 HRD68_RS08200 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) HRD68_RS08205 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) HRD68_RS08210 ENOG4105PM1 preprotein translocase subunit SecE HRD68_RS08245 ENOG4105CS9 pantothenic acid kinase HRD68_RS08250 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase HRD68_RS08280 ENOG4108RR8 protoporphyrinogen oxidase HRD68_RS08285 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) HRD68_RS08290 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein HRD68_RS08300 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HRD68_RS08305 ENOG4105CHU acetyl-coa acetyltransferase HRD68_RS08310 ENOG4107QK7 reductase HRD68_RS08315 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HRD68_RS08320 ENOG4105MDZ Transcriptional activator rfaH HRD68_RS08325 ENOG4105D52 delta-aminolevulinic acid dehydratase HRD68_RS08335 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) HRD68_RS08345 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HRD68_RS08350 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) HRD68_RS08355 ENOG4105JC1 sterol-binding domain protein HRD68_RS08360 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HRD68_RS08365 ENOG4105CGY Dna recombination protein HRD68_RS08370 ENOG4108KF1 Membrane HRD68_RS08385 ENOG4107SXA Phosphorylase HRD68_RS08390 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) HRD68_RS08395 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) HRD68_RS08400 ENOG4105DZ2 Transcriptional regulator HRD68_RS08405 ENOG4105EMK carboxylate amino acid amine transporter HRD68_RS08410 ENOG4105RK9 auxin efflux carrier HRD68_RS08415 ENOG4107T6V glycerophosphoryl diester phosphodiesterase HRD68_RS08420 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HRD68_RS08425 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component HRD68_RS08430 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component HRD68_RS08435 ENOG4105BZ7 extracellular solute-binding protein family 1 HRD68_RS08470 ENOG4108IV0 ABC, transporter HRD68_RS08475 ENOG4105C0Z ABC transporter HRD68_RS08480 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HRD68_RS08485 ENOG4105C32 Amino acid ABC transporter (Permease) HRD68_RS08490 ENOG4105CP9 extracellular ligand-binding receptor HRD68_RS08495 ENOG4105U59 -acetyltransferase HRD68_RS08505 ENOG4105CRP Part of the ABC transporter FtsEX involved in HRD68_RS08510 ENOG4105CAK Cell division ATP-binding protein ftsE HRD68_RS08515 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) HRD68_RS08515 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) HRD68_RS08520 ENOG4106H78 methyltransferase HRD68_RS08525 ENOG4105MG3 Membrane HRD68_RS08540 ENOG4107FS9 Membrane HRD68_RS08550 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) HRD68_RS08555 ENOG4105EX9 Membrane HRD68_RS08560 ENOG4108W1V Lipoprotein HRD68_RS08565 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HRD68_RS08575 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A HRD68_RS08580 ENOG4105CXY transporter HRD68_RS08585 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase HRD68_RS08590 ENOG4105DQF Hydrolase HRD68_RS08595 ENOG4108EUD Lysophospholipase HRD68_RS08600 ENOG410829K Lysine exporter protein (Lyse ygga) HRD68_RS08605 ENOG4105CCF Lysine exporter protein (Lyse ygga) HRD68_RS08610 ENOG4105C9U ATP-dependent DNA helicase RecQ HRD68_RS08615 ENOG4105HDD phospholipase HRD68_RS08620 ENOG4108VUY thioesterase Superfamily protein HRD68_RS08625 ENOG4105FR1 rard protein HRD68_RS08650 ENOG4105C4R Atp-dependent dna helicase HRD68_RS08655 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant HRD68_RS08660 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HRD68_RS08665 ENOG4105CT0 Protein of unknown function, DUF484 HRD68_RS08670 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) HRD68_RS08675 ENOG4105S7Z (LipO)protein HRD68_RS08690 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) HRD68_RS08695 ENOG41076E6 Uroporphyrinogen-III Synthase HRD68_RS08700 ENOG4105ECF c-methyltransferase HRD68_RS08705 ENOG410601J HemY protein HRD68_RS08730 ENOG4105C85 amino acid HRD68_RS08745 ENOG4105F18 Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis (By similarity) HRD68_RS08750 ENOG4105EGZ biosynthesis protein HRD68_RS08755 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HRD68_RS08760 ENOG4108WJ1 acetyltransferase HRD68_RS08765 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) HRD68_RS08770 ENOG4105C1B dTDP-glucose 4-6-dehydratase HRD68_RS08775 ENOG4108IJ1 Dehydrogenase HRD68_RS08780 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase HRD68_RS08785 ENOG4105SFE lipopolysaccharide biosynthesis protein HRD68_RS08790 ENOG4105ESV Glycosyl transferase, family 4 HRD68_RS08795 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) HRD68_RS08810 ENOG4105C9X ppx gppa phosphatase HRD68_RS08820 ENOG4105C4R Atp-dependent dna helicase HRD68_RS08825 ENOG4105KQ5 peptidylprolyl cis-trans isomerase HRD68_RS08835 ENOG4108MQF Chaperone HRD68_RS08840 ENOG4105CW0 outer membrane usher protein HRD68_RS08850 ENOG4108VEV chaperone HRD68_RS08855 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase HRD68_RS08860 ENOG4105EMY transcriptional regulator HRD68_RS08870 ENOG4105C7B Threonine dehydratase HRD68_RS08875 ENOG4105C01 Dihydroxy-acid dehydratase HRD68_RS08880 ENOG4105CM2 brancheD-chain amino acid aminotransferase HRD68_RS08885 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit HRD68_RS08900 ENOG4105C0P Mg chelatase subunit ChlI HRD68_RS08905 ENOG4108WFC UPF0438 protein yifE HRD68_RS08910 ENOG4105CVI Transcriptional regulator HRD68_RS08915 ENOG41062B0 ABC transporter, permease HRD68_RS08920 ENOG4107R9N ABC transporter HRD68_RS08925 ENOG4105C2J ABC transporter HRD68_RS08930 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator HRD68_RS08970 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) HRD68_RS08980 ENOG4107R9T Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity) HRD68_RS08985 ENOG4108Y73 Membrane HRD68_RS08995 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) HRD68_RS09000 ENOG4105C5Q Transcriptional regulator HRD68_RS09005 ENOG4105EHV domain protein HRD68_RS09010 ENOG4107QN2 dihydrolipoyl dehydrogenase HRD68_RS09020 ENOG4107QZV Type I secretion membrane fusion protein HRD68_RS09035 ENOG4105X58 receptor HRD68_RS09040 ENOG4105CH7 arginosuccinase HRD68_RS09060 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) HRD68_RS09065 ENOG4105DP0 ferredoxin-NADP reductase HRD68_RS09070 ENOG4105E5M Multidrug resistance protein D HRD68_RS09075 ENOG4105CBT Fructose-1,6-bisphosphatase HRD68_RS09080 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HRD68_RS09085 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HRD68_RS09090 ENOG4105N4M Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity) HRD68_RS09095 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) HRD68_RS09100 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase HRD68_RS09105 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) HRD68_RS09110 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) HRD68_RS09115 ENOG41063M6 Cell Division Protein HRD68_RS09120 ENOG4105ETE Transcriptional regulator (LacI family HRD68_RS09125 ENOG4105C25 Primosomal protein n' HRD68_RS09130 ENOG4105VFB Binds the 23S rRNA (By similarity) HRD68_RS09135 ENOG4105GGQ This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity) HRD68_RS09140 ENOG4105C28 cystathionine HRD68_RS09145 ENOG4105CFH Aspartokinase HRD68_RS09150 ENOG4105SYT Methylenetetrahydrofolate reductase HRD68_RS09155 ENOG4108VTS Membrane HRD68_RS09160 ENOG4105EBK exported protein HRD68_RS09175 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein HRD68_RS09185 ENOG41076HS cation diffusion facilitator family transporter HRD68_RS09190 ENOG4105FMW periplasmic HRD68_RS09195 ENOG4105E3W Two component transcriptional regulator (Winged helix family HRD68_RS09200 ENOG4105E0F Histidine kinase HRD68_RS09205 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HRD68_RS09210 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) HRD68_RS09215 ENOG4105D7W serine acetyltransferase HRD68_RS09220 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase HRD68_RS09225 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) HRD68_RS09230 ENOG4105VW4 glutaredoxin 3 HRD68_RS09235 ENOG4107YZP Rhodanese domain protein HRD68_RS09240 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HRD68_RS09245 ENOG41063SB peptidase HRD68_RS09250 ENOG4105PXI polysaccharide deacetylase HRD68_RS09260 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HRD68_RS09265 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) HRD68_RS09270 ENOG4105XA0 heptosyltransferase ii HRD68_RS09275 ENOG4105D16 lipopolysaccharide heptosyltransferase i HRD68_RS09280 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase HRD68_RS09295 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) HRD68_RS09300 ENOG4105W0E 50S ribosomal protein L33 HRD68_RS09305 ENOG4105KDC 50s ribosomal protein l28 HRD68_RS09315 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase HRD68_RS09320 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) HRD68_RS09325 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) HRD68_RS09335 ENOG4108PU9 oligogalacturonate-specific porin HRD68_RS09345 ENOG4105BZU Histidine kinase HRD68_RS09350 ENOG4108JQ7 (ABC) transporter HRD68_RS09355 ENOG4105C3U ABC transporter HRD68_RS09360 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HRD68_RS09365 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HRD68_RS09370 ENOG4105DEF Extracellular solute-binding protein, family 5 HRD68_RS09385 ENOG4105D5K Hemolysin activator protein HRD68_RS09395 ENOG4105CXY transporter HRD68_RS09400 ENOG4105BZU Histidine kinase HRD68_RS09405 ENOG4108KX4 response regulator HRD68_RS09410 ENOG4105DIJ Phosphoethanolamine transferase HRD68_RS09415 ENOG4108ZHJ Organic hydroperoxide resistance protein HRD68_RS09425 ENOG4105C85 amino acid HRD68_RS09430 ENOG4105C84 Histidine ammonia-lyase HRD68_RS09435 ENOG4105CGP Urocanate hydratase HRD68_RS09440 ENOG4105BZU Histidine kinase HRD68_RS09445 ENOG4105E39 Enoyl-CoA hydratase HRD68_RS09450 ENOG4105D9N nucleoside HRD68_RS09460 ENOG4105EN6 Membrane HRD68_RS09465 ENOG410649J Catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction (By similarity) HRD68_RS09475 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) HRD68_RS09480 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HRD68_RS09485 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase HRD68_RS09490 ENOG4105CB5 ATP-dependent DNA helicase recG HRD68_RS09495 ENOG4105D6U Sodium Glutamate Symporter HRD68_RS09500 ENOG4105C2W permease HRD68_RS09505 ENOG4105JV1 AsmA family HRD68_RS09525 ENOG4105SUU thioesterase domain HRD68_RS09535 ENOG4107S2Z UPF0761 membrane protein HRD68_RS09540 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 HRD68_RS09545 ENOG4105CI3 gtp-binding protein typa HRD68_RS09550 ENOG4105C5F glutamine synthetase HRD68_RS09555 ENOG4105CUX Signal transduction histidine kinase HRD68_RS09560 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HRD68_RS09565 ENOG4105D4P Coproporphyrinogen iii oxidase HRD68_RS09570 ENOG4105ZR3 A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity) HRD68_RS09575 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) HRD68_RS09580 ENOG4105C2M dna polymerase I HRD68_RS09585 ENOG4108Z33 Thiol disulfide Interchange Protein HRD68_RS09590 ENOG4105E27 serine threonine protein kinase HRD68_RS09595 ENOG4105PC1 Conserved Protein HRD68_RS09605 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b HRD68_RS09630 ENOG4107EJG GntR family transcriptional regulator HRD68_RS09635 ENOG4105C0R drug resistance transporter emrb qaca subfamily HRD68_RS09640 ENOG4105ETE Transcriptional regulator (LacI family HRD68_RS09645 ENOG4108RVA ribokinase HRD68_RS09650 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HRD68_RS09655 ENOG4105CNN ABC, transporter HRD68_RS09665 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) HRD68_RS09675 ENOG4107R4Q Functions as an ATPase. May play a role in metal insertion (metal-chelatase) or as a chaperone (By similarity) HRD68_RS09680 ENOG4105EV2 VWA domain protein interacting with AAA ATPase HRD68_RS09690 ENOG4105CU9 asparagine synthetase A HRD68_RS09695 ENOG4108VVK transcriptional Regulator, AsnC HRD68_RS09700 ENOG4105QTB Flavodoxin HRD68_RS09705 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) HRD68_RS09710 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) HRD68_RS09715 ENOG4105GXX Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation HRD68_RS09720 ENOG4105EE4 it plays a direct role in the translocation of protons across the membrane (By similarity) HRD68_RS09725 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) HRD68_RS09730 ENOG4107Z6K F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) HRD68_RS09735 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) HRD68_RS09740 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) HRD68_RS09745 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) HRD68_RS09750 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) HRD68_RS09755 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) HRD68_RS09760 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) HRD68_RS09770 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) HRD68_RS09775 ENOG4105C8U phosphate abc transporter HRD68_RS09780 ENOG4105E2Z phosphate ABC transporter (Permease HRD68_RS09795 ENOG4106PMH Extracellular solute-binding protein family 3 HRD68_RS09800 ENOG4105EAD ABC transporter HRD68_RS09805 ENOG4105DRP amino acid AbC transporter HRD68_RS09810 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 HRD68_RS09815 ENOG4105C7N Xanthine uracil vitamin C permease HRD68_RS09830 ENOG4105BZU Histidine kinase HRD68_RS09835 ENOG4108YYH Nadph-dependent fmn reductase HRD68_RS09840 ENOG4105C8Q Methyl-accepting chemotaxis HRD68_RS09845 ENOG4108UMI ABC transporter, permease HRD68_RS09850 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HRD68_RS09880 ENOG4105RKW reductase (By HRD68_RS09885 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) HRD68_RS09890 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins HRD68_RS09900 ENOG4105NVJ RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) HRD68_RS09910 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) HRD68_RS09915 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HRD68_RS09925 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HRD68_RS09930 ENOG410667J hydrolase HRD68_RS09945 ENOG4108SGR YheO domain-containing protein HRD68_RS09950 ENOG4105D99 atp gtp-binding protein HRD68_RS09955 ENOG4105R2A (LipO)protein HRD68_RS09970 ENOG4105D0C transport protein HRD68_RS09975 ENOG4105JKW Valine--pyruvate aminotransferase HRD68_RS09980 ENOG4107T9C Alpha amylase catalytic region HRD68_RS10000 ENOG4108ZG0 Ompa motb domain protein HRD68_RS10015 ENOG4108R3E Dna-3-methyladenine glycosylase i HRD68_RS10025 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit HRD68_RS10030 ENOG4105C38 Glycyl-tRNA synthetase beta subunit HRD68_RS10035 ENOG4106JH6 (LipO)protein HRD68_RS10045 ENOG4105EM7 Selenocysteine-specific translation elongation factor HRD68_RS10050 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) HRD68_RS10055 ENOG4105F46 Necessary for formate dehydrogenase activity (By similarity) HRD68_RS10060 ENOG4108MG3 formate dehydrogenase HRD68_RS10065 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HRD68_RS10075 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) HRD68_RS10080 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HRD68_RS10085 ENOG4105C8Q Methyl-accepting chemotaxis HRD68_RS10090 ENOG4108RPX mosc domain containing protein HRD68_RS10100 ENOG4108YYI Protein of unknown function (DUF2810) HRD68_RS10105 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HRD68_RS10115 ENOG4105E61 Mannitol repressor protein HRD68_RS10120 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase HRD68_RS10125 ENOG4105CTS PTS system mannitol-specific HRD68_RS10130 ENOG4105MEV Acyl-transferase HRD68_RS10135 ENOG4105ECQ AraC Family Transcriptional Regulator HRD68_RS10140 ENOG4108RWI nicotinamidase HRD68_RS10155 ENOG4108TTM chaperone HRD68_RS10165 ENOG4105CMG Carbohydrate kinase HRD68_RS10170 ENOG4105C93 Xylose Isomerase HRD68_RS10175 ENOG4105DFW ABC transporter HRD68_RS10185 ENOG4108HWW ABC transporter HRD68_RS10190 ENOG4105T16 Transcriptional regulator (AraC family) HRD68_RS10200 ENOG4105DFP Integrase HRD68_RS10210 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein HRD68_RS10230 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) HRD68_RS10280 ENOG4106H6R UPF0380 protein HRD68_RS10285 ENOG4108XS9 dna repair protein HRD68_RS10290 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles HRD68_RS10295 ENOG4108X3P Toxic component of a toxin-antitoxin (TA) module. Overexpression results in inhibition of growth in liquid cultures HRD68_RS10305 ENOG4105CKT filamentous hemagglutinin HRD68_RS10310 ENOG4105D5K Hemolysin activator protein HRD68_RS10330 ENOG4108KTU conserved protein with FAD NAD(P)-binding domain HRD68_RS10350 ENOG4105DSJ YicC domain protein HRD68_RS10355 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) HRD68_RS10360 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) HRD68_RS10365 ENOG4105CK2 sodium dicarboxylate symporter HRD68_RS10370 ENOG4105CS0 peptidase HRD68_RS10375 ENOG4107SS6 2-dehydro-3-deoxygluconokinase HRD68_RS10380 ENOG4105VSH 4-oxalocrotonate tautomerase HRD68_RS10385 ENOG4105CMB EAL domain-containing protein HRD68_RS10390 ENOG41066T0 asmA family HRD68_RS10395 ENOG4105EAF CDP-diacylglycerol pyrophosphatase (EC 3.6.1.26) HRD68_RS10400 ENOG4107H3J ribonuclease HRD68_RS10405 ENOG4105DC8 reductase HRD68_RS10410 ENOG4105D6S protein involved in catabolism of external DNA HRD68_RS10420 ENOG4105DGW oligopeptidase A HRD68_RS10425 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) HRD68_RS10440 ENOG4108M6U Universal stress protein A HRD68_RS10445 ENOG4108V6B universal stress protein B HRD68_RS10450 ENOG4105CJ3 phosphate transporter HRD68_RS10455 ENOG4105CBX hi0933 family HRD68_RS10460 ENOG4108Q9V regulatoR HRD68_RS10465 ENOG4107ZHV Transcriptional regulator HRD68_RS10475 ENOG4105CR8 Transcriptional regulator HRD68_RS10480 ENOG4105EQ0 Major Facilitator superfamily HRD68_RS10495 ENOG4105C26 Dehydrogenase HRD68_RS10500 ENOG4105DH8 myo-inositol catabolism HRD68_RS10520 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) HRD68_RS10525 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) HRD68_RS10530 ENOG4105WCN acetyltransferase HRD68_RS10535 ENOG4105C2I pirin domain protein HRD68_RS10540 ENOG4105DIQ Transcriptional regulator HRD68_RS10545 ENOG4105C6Z Gluconate HRD68_RS10550 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family HRD68_RS10555 ENOG41076UM multiple antibiotic resistance (MarC)-related protein HRD68_RS10560 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HRD68_RS10565 ENOG4108HRK Histidine kinase HRD68_RS10570 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) HRD68_RS10575 ENOG4108IUM Glycogen debranching enzyme HRD68_RS10585 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) HRD68_RS10590 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) HRD68_RS10595 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HRD68_RS10600 ENOG4105E98 transcriptional regulator DeoR family HRD68_RS10605 ENOG4105EBW Rhomboid-type serine protease that catalyzes intramembrane proteolysis (By similarity) HRD68_RS10620 ENOG41061ZR Transcriptional regulator HRD68_RS10625 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) HRD68_RS10630 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) HRD68_RS10635 ENOG4107RUK Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity) HRD68_RS10640 ENOG4105MJ2 Competence protein HRD68_RS10645 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) HRD68_RS10650 ENOG4105RID UPF0379 protein yhcN HRD68_RS10655 ENOG41060N5 May function as a transcriptional regulator that controls feoABC expression (By similarity) HRD68_RS10660 ENOG4105CE1 Ferrous iron transport protein b HRD68_RS10665 ENOG4105XFK Ferrous iron transport protein A HRD68_RS10670 ENOG4105BZM domain protein HRD68_RS10675 ENOG4108RRZ Transcription elongation factor GreB HRD68_RS10685 ENOG4105E0F Histidine kinase HRD68_RS10700 ENOG4108S1B Periplasmic chaperone protein HRD68_RS10705 ENOG4108D1K outer membrane usher protein HRD68_RS10725 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase HRD68_RS10735 ENOG4105VEJ Heat shock protein HRD68_RS10740 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 HRD68_RS10745 ENOG4105DQY intracellular growth attenuator HRD68_RS10750 ENOG4107RK2 ADP-ribose diphosphatase NudE HRD68_RS10755 ENOG4108JQC penicillin-binding protein 1A HRD68_RS10780 ENOG4105E4G Type IV pilus HRD68_RS10785 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) HRD68_RS10805 ENOG4105DJV ribulose-phosphate 3-epimerase HRD68_RS10815 ENOG4105C31 Tryptophanyl-tRNA synthetase HRD68_RS10820 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HRD68_RS10825 ENOG4107V9H nitrite transporter HRD68_RS10830 ENOG4105WZK nitrite reductase NADPH small subunit HRD68_RS10835 ENOG4107QZF nitrite reductase NADPH large subunit HRD68_RS10840 ENOG4105DZC cytosine deaminase HRD68_RS10845 ENOG4106DTQ Protein TsgA homolog HRD68_RS10855 ENOG4107RNH Outer membrane receptor FepA HRD68_RS10860 ENOG41060NJ transcriptional regulator HRD68_RS10865 ENOG4105F8D glycoside hydrolase family 4 HRD68_RS10870 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) HRD68_RS10875 ENOG4105D7A ATP-binding protein HRD68_RS10885 ENOG4105C8Y Acetylornithine aminotransferase HRD68_RS10920 ENOG4105TNG K13735 adhesin invasin HRD68_RS10935 ENOG410613R integral membrane protein, YccS YhfK family HRD68_RS10940 ENOG4107RYR Transcriptional regulator, Crp Fnr family HRD68_RS10945 ENOG4108UKZ OsmC family HRD68_RS10950 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) HRD68_RS10955 ENOG4105YP7 UPF0270 protein HRD68_RS10960 ENOG4105DNZ Alpha Beta Hydrolase HRD68_RS10970 ENOG4105JAB phenazine biosynthesis protein, phzf family HRD68_RS10975 ENOG4106FTQ Taurine ABC transporter, periplasmic HRD68_RS10985 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component HRD68_RS10990 ENOG4105E2B Taurine dioxygenase HRD68_RS11000 ENOG4105C5H ABC transporter HRD68_RS11005 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein HRD68_RS11015 ENOG4105VKU nucleicacid-binding protein HRD68_RS11020 ENOG4108YZY peptidylprolyl cis-trans isomerase HRD68_RS11030 ENOG4108V1T peptidylprolyl cis-trans isomerase HRD68_RS11035 ENOG4105WWK YheO domain protein HRD68_RS11040 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) HRD68_RS11050 ENOG4105YKK Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) HRD68_RS11060 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) HRD68_RS11070 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) HRD68_RS11090 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) HRD68_RS11095 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) HRD68_RS11100 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) HRD68_RS11110 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) HRD68_RS11115 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) HRD68_RS11120 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) HRD68_RS11125 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) HRD68_RS11130 ENOG41083MP 50s ribosomal protein l29 HRD68_RS11135 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal HRD68_RS11155 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) HRD68_RS11165 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) HRD68_RS11170 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) HRD68_RS11175 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) HRD68_RS11180 ENOG4105VPB 50S ribosomal protein L30 HRD68_RS11185 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) HRD68_RS11190 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) HRD68_RS11200 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits HRD68_RS11205 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) HRD68_RS11210 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) HRD68_RS11215 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HRD68_RS11220 ENOG4108ZT0 50S ribosomal protein l17 HRD68_RS11225 ENOG4105VTS DnaJ-like, subfamily C HRD68_RS11230 ENOG4105W1Y Transcriptional regulator HRD68_RS11235 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system HRD68_RS11240 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) HRD68_RS11245 ENOG4105C1A potassium transporter peripheral membrane HRD68_RS11250 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B HRD68_RS11255 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) HRD68_RS11260 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HRD68_RS11265 ENOG4105C79 DNA protecting protein DprA HRD68_RS11275 ENOG4108WI1 Dna topoisomerase HRD68_RS11280 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HRD68_RS11285 ENOG4105E2X shikimate dehydrogenase HRD68_RS11290 ENOG4108Z0R Transferase HRD68_RS11320 ENOG4105CVG Homoserine O-transsuccinylase HRD68_RS11325 ENOG4107QP3 malate synthase g HRD68_RS11330 ENOG4108I9X Isocitrate lyase HRD68_RS11335 ENOG4105VS7 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) HRD68_RS11340 ENOG41069M3 Transcriptional regulator HRD68_RS11345 ENOG4105C3R Methionine synthase HRD68_RS11350 ENOG4105C09 Bile acid HRD68_RS11355 ENOG4105CFH Aspartokinase HRD68_RS11370 ENOG4105EG2 ABC transporter, permease HRD68_RS11375 ENOG4105D56 permease protein HRD68_RS11380 ENOG4107FKK extracellular solute-binding protein family 1 HRD68_RS11390 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) HRD68_RS11395 ENOG4107W52 maltose operon periplasmic protein HRD68_RS11400 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) HRD68_RS11410 ENOG4105E55 glycerol-3-phosphate acyltransferase HRD68_RS11415 ENOG41080IJ Diacylglycerol kinase HRD68_RS11420 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) HRD68_RS11425 ENOG4105VDW Csbd family HRD68_RS11430 ENOG4105MYN Zinc uptake regulation protein HRD68_RS11440 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HRD68_RS11445 ENOG4105P4Z Phage shock protein G HRD68_RS11450 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HRD68_RS11455 ENOG4105CDU Replicative dna helicase HRD68_RS11465 ENOG4105CGF Aromatic amino acid aminotransferase HRD68_RS11470 ENOG4105MSB protein, conserved in bacteria HRD68_RS11475 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HRD68_RS11480 ENOG4108UUM single-stranded DNA-binding protein HRD68_RS11500 ENOG4105C7N Xanthine uracil vitamin C permease HRD68_RS11505 ENOG4105EEQ Na H antiporter HRD68_RS11510 ENOG4105CMU LysR family (Transcriptional regulator HRD68_RS11520 ENOG41067MG lrgb family HRD68_RS11525 ENOG4105CDA abc transporter atp-binding protein HRD68_RS11530 ENOG4105DRP amino acid AbC transporter HRD68_RS11535 ENOG4105EZ7 amino acid ABC transporter HRD68_RS11550 ENOG4105D1S lipid A biosynthesis HRD68_RS11560 ENOG4105C2J ABC transporter HRD68_RS11565 ENOG4105CNN ABC, transporter HRD68_RS11575 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HRD68_RS11580 ENOG4105C2X Arabinose 5-phosphate isomerase HRD68_RS11585 ENOG4107QPK )-transporter HRD68_RS11590 ENOG4105VEQ Cold shock protein HRD68_RS11595 ENOG4105VEQ Cold shock protein HRD68_RS11600 ENOG4108XTF Outer Membrane Lipoprotein HRD68_RS11615 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) HRD68_RS11620 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HRD68_RS11625 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) HRD68_RS11630 ENOG4108IA2 Sodium pantothenate symporter HRD68_RS11635 ENOG4105RG0 Membrane HRD68_RS11640 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HRD68_RS11645 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein HRD68_RS11655 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) HRD68_RS11665 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family HRD68_RS11670 ENOG41062P1 Diguanylate cyclase phosphodiesterase HRD68_RS11680 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) HRD68_RS11685 ENOG4105VQ7 Rod shape-determining protein MreD HRD68_RS11690 ENOG4108Z03 MAF-like protein HRD68_RS11695 ENOG4105C03 ribonuclease HRD68_RS11700 ENOG4105QD6 exported protein HRD68_RS11710 ENOG4105D1U peptidase U62 modulator of DNA gyrase HRD68_RS11715 ENOG4105CR8 Transcriptional regulator HRD68_RS11720 ENOG4105ZQC membrane protein AaeX HRD68_RS11725 ENOG4105Y49 secretion protein, HlyD family HRD68_RS11730 ENOG4107Z11 Efflux pump whose substrates are p-hydroxybenzoic acid (pHBA), 6-hydroxy-2-naphthoic and 2-hydroxycinnamate. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell (By similarity) HRD68_RS11745 ENOG4105UNR (Barnase) inhibitor HRD68_RS11750 ENOG4105N42 UPF0307 protein HRD68_RS11755 ENOG4105CMS peptidase U62, modulator of DNA gyrase HRD68_RS11765 ENOG4108XVM Cytochrome b(562) HRD68_RS11770 ENOG4105NXH GreA GreB family elongation factor HRD68_RS11800 ENOG41069H0 dihydroorotase EC 3.5.2.3 HRD68_RS11815 ENOG4105EMD TRANSCRIPTIONal HRD68_RS11825 ENOG4105D4X repressor HRD68_RS11830 ENOG4105C5Y PTS System HRD68_RS11835 ENOG4105CG3 alpha amylase, catalytic region HRD68_RS11840 ENOG4105I03 Flagellin HRD68_RS11870 ENOG4105KME endoribonuclease L-psp HRD68_RS11875 ENOG4108R9M Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity) HRD68_RS11880 ENOG4105CXT aspartate transcarbamylase HRD68_RS11885 ENOG41080Z8 PHOSPHOCARRIER protein HRD68_RS11895 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN HRD68_RS11900 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA HRD68_RS11905 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HRD68_RS11910 ENOG4108IUZ ABC transporter HRD68_RS11915 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA HRD68_RS11920 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) HRD68_RS11925 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase HRD68_RS11930 ENOG4105C2X Arabinose 5-phosphate isomerase HRD68_RS11935 ENOG4105FEU K -dependent Na -Ca exchanger HRD68_RS11940 ENOG4105DHJ ABC, transporter HRD68_RS11945 ENOG4105CY3 ABC transporter, permease HRD68_RS11950 ENOG4107PE3 Mammalian cell entry related domain protein HRD68_RS11955 ENOG4105E3I toluene tolerance HRD68_RS11960 ENOG4105UE2 Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane HRD68_RS11965 ENOG4105VFK BolA family HRD68_RS11970 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) HRD68_RS11975 ENOG4105C0H protease HRD68_RS11980 ENOG4105C0H protease HRD68_RS11985 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III HRD68_RS11995 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) HRD68_RS12000 ENOG4108UJD 30S ribosomal protein S9 HRD68_RS12005 ENOG4107MKT Stringent starvation protein a HRD68_RS12010 ENOG4105KB2 stringent starvation protein b HRD68_RS12020 ENOG4105BZ8 glutamate synthase HRD68_RS12025 ENOG4105CBC glutamate synthase HRD68_RS12030 ENOG4105N5T Radical SAM Protein HRD68_RS12035 ENOG4105BZU Histidine kinase HRD68_RS12040 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain HRD68_RS12045 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase HRD68_RS12050 ENOG4105W4M Transport-associated protein HRD68_RS12055 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) HRD68_RS12060 ENOG41082RQ UPF0102 protein HRD68_RS12070 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) HRD68_RS12095 ENOG4105EQ2 LysR family Transcriptional regulator HRD68_RS12105 ENOG4105DQ4 alcohol dehydrogenase HRD68_RS12110 ENOG4108CNN domain protein HRD68_RS12115 ENOG4105CWB LysR family transcriptional Regulator HRD68_RS12120 ENOG4105CHF Glutathione S-transferase HRD68_RS12125 ENOG4108VBZ doxx family HRD68_RS12130 ENOG4105YJD HRD68_RS12135 ENOG41090KG Inner membrane protein YqjE HRD68_RS12140 ENOG4105NE1 Conserved Protein HRD68_RS12155 ENOG4106W5V Membrane HRD68_RS12170 ENOG4105DPW Major facilitator superfamily MFS_1 HRD68_RS12175 ENOG4105D2H Uronic isomerase HRD68_RS12180 ENOG4107QZW Altronate oxidoreductase HRD68_RS12185 ENOG4105CTX dehydratase HRD68_RS12190 ENOG4105P66 Membrane HRD68_RS12195 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) HRD68_RS12200 ENOG4105DU1 integral membrane protein, terc HRD68_RS12210 ENOG4105EE0 oxidoreductase HRD68_RS12215 ENOG4108VKG metal-dependent hydrolase HRD68_RS12220 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) HRD68_RS12230 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HRD68_RS12235 ENOG4108YK4 Acid-resistance membrane protein HRD68_RS12245 ENOG4108UHU Aldolase HRD68_RS12250 ENOG4108I5G Major Facilitator superfamily HRD68_RS12265 ENOG4105C0A alcohol dehydrogenase HRD68_RS12270 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HRD68_RS12285 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HRD68_RS12345 ENOG4105ED4 portal protein HRD68_RS12420 ENOG4105M03 Domain of unknown function (DUF955) HRD68_RS12495 ENOG4105ZTC transcriptional activator, Ogr delta HRD68_RS12505 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HRD68_RS12510 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) HRD68_RS12520 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HRD68_RS12525 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) HRD68_RS12530 ENOG4107ZVW dihydroneopterin aldolase HRD68_RS12535 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) HRD68_RS12540 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate HRD68_RS12545 ENOG4106MWK domain protein HRD68_RS12550 ENOG4105I7R Adenylate cyclase HRD68_RS12555 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) HRD68_RS12560 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) HRD68_RS12565 ENOG4105DVH amino acid HRD68_RS12570 ENOG4105W0Z cytoplasmic protein HRD68_RS12575 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) HRD68_RS12580 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b HRD68_RS12585 ENOG4106032 Glutathionylspermidine synthase HRD68_RS12590 ENOG4105F1G UPF0441 protein HRD68_RS12595 ENOG4105DFG type I secretion outer membrane protein HRD68_RS12600 ENOG41087AY ADP-Ribose pyrophosphatase HRD68_RS12605 ENOG4108SX3 cytoplasmic protein HRD68_RS12610 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) HRD68_RS12615 ENOG4105IPS esterase HRD68_RS12620 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HRD68_RS12625 ENOG4105JQN Transcriptional regulator HRD68_RS12630 ENOG4105VRH Antibiotic biosynthesis monooxygenase HRD68_RS12635 ENOG4105NF4 modulator of drug activity HRD68_RS12640 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HRD68_RS12645 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase HRD68_RS12650 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) HRD68_RS12660 ENOG4105CV8 reductase HRD68_RS12665 ENOG4108I6A alcohol dehydrogenase HRD68_RS12670 ENOG4105CF7 AraC family transcriptional regulator HRD68_RS12675 ENOG4108K81 inner membrane protein YghB HRD68_RS12680 ENOG4105C28 cystathionine HRD68_RS12685 ENOG4105CWK Biopolymer transport protein, ExbB HRD68_RS12690 ENOG4108ZZF transport protein (ExbD) HRD68_RS12765 ENOG4108IJF Heavy metal efflux pump, CzcA HRD68_RS12770 ENOG4105EP1 Efflux transporter rnd family, mfp subunit HRD68_RS12795 ENOG4105E0A ABC, transporter HRD68_RS12800 ENOG4105TVJ transport system, permease HRD68_RS12805 ENOG4105DQ5 transport system permease protein HRD68_RS12825 ENOG4105ETE Transcriptional regulator (LacI family HRD68_RS12835 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein HRD68_RS12840 ENOG4105C8Q Methyl-accepting chemotaxis HRD68_RS12855 ENOG4108M3R transcriptional activator CadC HRD68_RS12860 ENOG4108XTF Outer Membrane Lipoprotein HRD68_RS12865 ENOG4105E3S small subunit HRD68_RS12870 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HRD68_RS12875 ENOG4105CJ5 hydrogenase 2 b cytochrome subunit HRD68_RS12880 ENOG4105DPX Hydrogenase, large subunit HRD68_RS12885 ENOG4108USZ hydrogenase HRD68_RS12890 ENOG4108WGS hydrogenase 2-specific chaperone HRD68_RS12895 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) HRD68_RS12900 ENOG4107RSS Hydrogenase accessory protein HypB HRD68_RS12905 ENOG41082MF Hydrogenase assembly chaperone hypC hupF HRD68_RS12910 ENOG4105CQS hydrogenase expression formation protein HypD HRD68_RS12915 ENOG4105C45 hydrogenase expression formation protein (HypE) HRD68_RS12920 ENOG4105C8H hydrogenase maturation protein Hypf HRD68_RS12925 ENOG4108KKZ (LipO)protein HRD68_RS12935 ENOG4107QPK )-transporter HRD68_RS12940 ENOG4107GFK fumarate HRD68_RS12945 ENOG4106DSS Tartrate dehydratase subunit alpha HRD68_RS12950 ENOG4105EJC lysr family transcriptional regulator HRD68_RS12955 ENOG4105C1P efflux transporter, rnd family, mfp subunit HRD68_RS12965 ENOG4105C85 amino acid HRD68_RS12970 ENOG4105CPD ethanolamine ammonia-lyase HRD68_RS12975 ENOG4107FQ9 ethanolamine ammonia-lyase HRD68_RS12980 ENOG4105CSH Transporter HRD68_RS12995 ENOG4105EAM Na Pi-cotransporter HRD68_RS13005 ENOG4105ETE Transcriptional regulator (LacI family HRD68_RS13025 ENOG4105CM4 permease protein HRD68_RS13030 ENOG4108IPW abc transporter atp-binding protein HRD68_RS13035 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HRD68_RS13050 ENOG4105D2N Aldolase HRD68_RS13055 ENOG4105E70 isomerase HRD68_RS13060 ENOG4105CE4 GlcNAc 6-P deacetylase HRD68_RS13065 ENOG4108YTN IIa component HRD68_RS13070 ENOG4105F3R pts system mannose fructose sorbose family iid HRD68_RS13080 ENOG4108RG5 PTS system N-acetylgalactosamine-specific transporter subunit IIB HRD68_RS13085 ENOG4105C6Q that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of HRD68_RS13090 ENOG4105E98 transcriptional regulator DeoR family HRD68_RS13095 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) HRD68_RS13100 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein HRD68_RS13105 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HRD68_RS13110 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HRD68_RS13115 ENOG4108RZA ABC transporter HRD68_RS13120 ENOG4108S9F abc transporter, atp-binding protein HRD68_RS13125 ENOG4105D5K Hemolysin activator protein HRD68_RS13130 ENOG4105CKT filamentous hemagglutinin HRD68_RS13210 ENOG4108ZG0 Ompa motb domain protein HRD68_RS13220 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HRD68_RS13300 ENOG4105CI2 imidazolone-5-propionate hydrolase HRD68_RS13310 ENOG4105J12 Multidrug resistance protein mdtN HRD68_RS13315 ENOG4108MI0 Resistance protein HRD68_RS13435 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component HRD68_RS13455 ENOG4105TNG K13735 adhesin invasin HRD68_RS13475 ENOG4105C8Q Methyl-accepting chemotaxis HRD68_RS13480 ENOG4108WQH regulatoR HRD68_RS13505 ENOG4105M9M anti-sigma28 factor FlgM HRD68_RS13515 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) HRD68_RS13520 ENOG4108ZC9 flagellar basal-body rod protein flgc HRD68_RS13525 ENOG4105W00 Flagellar hook capping protein HRD68_RS13530 ENOG4105BZE flagellar hook protein, FlgE HRD68_RS13535 ENOG4108KPB Flagellar basal-body rod protein FlgF HRD68_RS13540 ENOG4105CGA flagellar basal-body rod protein FlgG HRD68_RS13555 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj HRD68_RS13560 ENOG4105E1Q flagellar hook-associated protein HRD68_RS13565 ENOG4105DTJ flagellar hook-associated protein HRD68_RS13570 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HRD68_RS13575 ENOG4105GEH Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways (By similarity) HRD68_RS13580 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region HRD68_RS13585 ENOG4107RD7 Flagellar Motor Protein, MotA HRD68_RS13590 ENOG4105ER2 Ompa motb domain protein HRD68_RS13595 ENOG4105CBS Chea signal transduction histidine kinase HRD68_RS13600 ENOG4108V3W Chemotaxis protein, CheW HRD68_RS13610 ENOG4105C8Q Methyl-accepting chemotaxis HRD68_RS13615 ENOG4105I03 Flagellin HRD68_RS13620 ENOG4105DTS flagellar hook-associated HRD68_RS13625 ENOG4105MQ3 flagellar protein FliS HRD68_RS13640 ENOG4105D7B Flagellar biosynthesis protein flha HRD68_RS13645 ENOG4105D00 flagellar biosynthetic protein flhB HRD68_RS13650 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) HRD68_RS13655 ENOG4108VYJ response regulator receiver protein HRD68_RS13660 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) HRD68_RS13665 ENOG4105BZU Histidine kinase HRD68_RS13670 ENOG4105VQ0 flagellar hook-basal body complex protein fliE HRD68_RS13675 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) HRD68_RS13680 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HRD68_RS13685 ENOG4108CG0 Flagellar assembly protein HRD68_RS13690 ENOG4108JIR Flagellum-specific ATP synthase HRD68_RS13700 ENOG4105WF4 Flagellar hook-length control protein HRD68_RS13705 ENOG4107ZI8 flagellar basal body-associated protein flil HRD68_RS13710 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HRD68_RS13715 ENOG4105DD5 Flagellar motor switch protein HRD68_RS13725 ENOG4105CN7 Flagellar biosynthetic protein FliP HRD68_RS13735 ENOG4105D19 Role in flagellar biosynthesis (By similarity) HRD68_RS13745 ENOG4105CJZ response regulator HRD68_RS13750 ENOG41066YJ Beta-lactamase HRD68_RS13760 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HRD68_RS13770 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HRD68_RS13775 ENOG4105D50 Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate (By similarity) HRD68_RS13785 ENOG4105DDC Oxidoreductase domain protein HRD68_RS13790 ENOG4105CAZ oligogalacturonide lyase HRD68_RS13795 ENOG410769Z extracellular solute-binding protein family 1 HRD68_RS13800 ENOG4107TRE AP endonuclease, family 2 HRD68_RS13805 ENOG4105C28 cystathionine HRD68_RS13810 ENOG4105C44 Serine transporter HRD68_RS13815 ENOG4105CR8 Transcriptional regulator HRD68_RS13825 ENOG4105VMP Transcriptional regulator HRD68_RS13840 ENOG4105GQR Chaperone HRD68_RS13845 ENOG4105CW0 outer membrane usher protein HRD68_RS13870 ENOG4105CXN decarboxylase HRD68_RS13875 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division HRD68_RS13885 ENOG4105CEN a g-specific adenine glycosylase HRD68_RS13890 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) HRD68_RS13895 ENOG41090ED Protein with unknown function (DUF469) HRD68_RS13905 ENOG4105K33 Periplasmic Protein HRD68_RS13910 ENOG4105CSA Coproporphyrinogen iii oxidase HRD68_RS13920 ENOG4105VZ9 UPF0235 protein HRD68_RS13925 ENOG4108VIA integral membrane protein HRD68_RS13930 ENOG4105II7 pyrroline-5-carboxylate reductase HRD68_RS13935 ENOG4105DFA alanine racemase domain protein HRD68_RS13940 ENOG4105CZX twitching motility protein HRD68_RS13950 ENOG4105DCY Is an aliphatic amidase with a restricted substrate specificity, as it only hydrolyzes formamide (By similarity) HRD68_RS13955 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) HRD68_RS13960 ENOG4108UJU UPF0301 protein HRD68_RS13965 ENOG4105D7Z glutathione synthase HRD68_RS13970 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) HRD68_RS13975 ENOG4105RWS endonuclease I HRD68_RS13980 ENOG4105GPY SprT protein HRD68_RS13985 ENOG41080HT Transcriptional regulator, arsr family HRD68_RS14000 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP HRD68_RS14005 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) HRD68_RS14015 ENOG4108K0D peptidase, M48 HRD68_RS14020 ENOG4105CV1 Transketolase (EC 2.2.1.1) HRD68_RS14025 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HRD68_RS14030 ENOG4105BZA Phosphoglycerate kinase HRD68_RS14035 ENOG4105D2N Aldolase HRD68_RS14045 ENOG4105D64 Mechanosensitive ion channel HRD68_RS14050 ENOG4108ZUB Lysine exporter protein (Lyse ygga) HRD68_RS14055 ENOG4105MPN Membrane HRD68_RS14060 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) HRD68_RS14065 ENOG4105E66 phosphoriboisomerase A HRD68_RS14070 ENOG4108JQ1 Dehydrogenase HRD68_RS14075 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase HRD68_RS14085 ENOG4107YUN Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) HRD68_RS14090 ENOG4105E07 UPF0149 protein HRD68_RS14095 ENOG4107RAQ aminopeptidase HRD68_RS14100 ENOG4105D0A hydroxylase HRD68_RS14105 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family HRD68_RS14110 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) HRD68_RS14115 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) HRD68_RS14120 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor HRD68_RS14125 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HRD68_RS14130 ENOG4108UT2 hemolysin iii HRD68_RS14135 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) HRD68_RS14150 ENOG4105E3W Two component transcriptional regulator (Winged helix family HRD68_RS14155 ENOG4105EB3 Histidine kinase HRD68_RS14160 ENOG4105CT7 inner membrane cred family protein HRD68_RS14165 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) HRD68_RS14170 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HRD68_RS14175 ENOG4105T95 Thiol disulfide interChange protein HRD68_RS14180 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) HRD68_RS14225 ENOG4105BZU Histidine kinase HRD68_RS14230 ENOG4105F7P transcriptional regulator AsnC family HRD68_RS14245 ENOG4105DPW Major facilitator superfamily MFS_1 HRD68_RS14255 ENOG4105DVC DnaJ domain protein HRD68_RS14265 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr HRD68_RS14270 ENOG4105KVH Transcriptional regulator HRD68_RS14305 ENOG4105EJC lysr family transcriptional regulator HRD68_RS14310 ENOG4105F27 Major Facilitator HRD68_RS14315 ENOG4105RQF LysR family Transcriptional regulator HRD68_RS14325 ENOG41060NJ transcriptional regulator HRD68_RS14335 ENOG4105CEY Amp-dependent synthetase and ligase HRD68_RS14340 ENOG4108J8Q Catalyzes the facilitated diffusion of 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) into the cell (By similarity) HRD68_RS14345 ENOG4108Z3N Transcriptional regulator HRD68_RS14350 ENOG4105CPC Aldo Keto reductase HRD68_RS14355 ENOG4105EE5 Membrane protein terC HRD68_RS14360 ENOG4105IRT Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair (By similarity) HRD68_RS14365 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) HRD68_RS14370 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase HRD68_RS14375 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) HRD68_RS14405 ENOG4105DSY exodeoxyribonuclease V, gamma HRD68_RS14410 ENOG4107QXK peptidase HRD68_RS14415 ENOG4107QKA exodeoxyribonuclease V beta HRD68_RS14420 ENOG4107QYX exodeoxyribonuclease v alpha HRD68_RS14425 ENOG4107QZM n-acetylglutamate synthase HRD68_RS14430 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HRD68_RS14450 ENOG4105CA3 membrane-bound lytic murein transglycosylase HRD68_RS14455 ENOG4105CUZ uba thif-type nad fad binding protein HRD68_RS14460 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) HRD68_RS14465 ENOG4105C9B Cysteine desulfurase HRD68_RS14470 ENOG4105M5B (LipO)protein HRD68_RS14475 ENOG4105ETT transcriptional Regulator, LysR family HRD68_RS14480 ENOG4105M08 Membrane HRD68_RS14485 ENOG4105EZ6 Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity) HRD68_RS14495 ENOG4105EWT decarboxylase family HRD68_RS14500 ENOG4107R1K Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) HRD68_RS14505 ENOG4108T6E Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity) HRD68_RS14510 ENOG4105WP7 tRNA pseudouridine synthase C HRD68_RS14515 ENOG4105DR9 pseudouridine synthase HRD68_RS14520 ENOG4105QDK Flavodoxin HRD68_RS14530 ENOG4108T8E UPF0325 protein HRD68_RS14535 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) HRD68_RS14540 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) HRD68_RS14545 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HRD68_RS14555 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) HRD68_RS14560 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) HRD68_RS14570 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) HRD68_RS14580 ENOG4105KNE Phosphatidate cytidylyltransferase HRD68_RS14585 ENOG4105DZP Membrane-associated zinc metalloprotease HRD68_RS14595 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) HRD68_RS14600 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HRD68_RS14610 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HRD68_RS14620 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HRD68_RS14625 ENOG4105C0B DNA polymerase III (alpha subunit) HRD68_RS14630 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) HRD68_RS14635 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase HRD68_RS14650 ENOG4105M1T rho-binding antiterminator HRD68_RS14660 ENOG4108VWS Yaeq family HRD68_RS14665 ENOG4108YZN class I peptide chain release factor HRD68_RS14670 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion HRD68_RS14675 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) HRD68_RS14680 ENOG4108R96 Methyltransferase, YaeB family HRD68_RS14685 ENOG4108R8X outer membrane lipoprotein HRD68_RS14690 ENOG4105D01 (LipO)protein HRD68_RS14695 ENOG4108UMI ABC transporter, permease HRD68_RS14705 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase HRD68_RS14740 ENOG4105HEI LysR family (Transcriptional regulator HRD68_RS14745 ENOG4105CV8 reductase HRD68_RS14750 ENOG4107NA1 Endonuclease Exonuclease phosphatase HRD68_RS14755 ENOG4105E9H Lytic Murein transglycosylase HRD68_RS14760 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) HRD68_RS14765 ENOG4105D1A Methyltransferase HRD68_RS14775 ENOG4107RZZ dna polymerase iii epsilon subunit HRD68_RS14785 ENOG4105GIJ Glycine betaine HRD68_RS14790 ENOG4108HQS Glycine betaine HRD68_RS14795 ENOG4108IJ7 Glycine betaine HRD68_RS14800 ENOG4107R25 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HRD68_RS14810 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) HRD68_RS14820 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HRD68_RS14830 ENOG4105NE1 Conserved Protein HRD68_RS14840 ENOG4108WMJ Protein of unknown function (DUF2002) HRD68_RS14845 ENOG4108SAJ Protein of unknown function (DUF1198) HRD68_RS14855 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein HRD68_RS14860 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HRD68_RS14865 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HRD68_RS14870 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) HRD68_RS14875 ENOG4105EFJ Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) HRD68_RS14885 ENOG4108YZ9 Urea amidohydrolase subunit gamma HRD68_RS14890 ENOG4105KI2 Urea amidohydrolase subunit beta HRD68_RS14895 ENOG4105CQM Urea amidohydrolase subunit alpha HRD68_RS14900 ENOG4108VDS Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity) HRD68_RS14910 ENOG4105E8T Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) HRD68_RS14930 ENOG4105XXV Acid-resistance protein HRD68_RS14935 ENOG4107SVH Potassium channel protein HRD68_RS14950 ENOG4105D8V Glucose sorbosone dehydrogenase HRD68_RS14955 ENOG4105VZJ PTS System HRD68_RS14960 ENOG4105CK1 PTS System HRD68_RS14965 ENOG4105VCP PTS System HRD68_RS14970 ENOG4105EZV Transcriptional regulator HRD68_RS14975 ENOG410901P UPF0249 protein HRD68_RS14985 ENOG4108SF5 RNA Polymerase HRD68_RS14990 ENOG4108S3W Anti-feci sigma factor, fecr HRD68_RS14995 ENOG4105GAV receptor HRD68_RS15000 ENOG4108HUF Transporter HRD68_RS15005 ENOG4105DQ5 transport system permease protein HRD68_RS15010 ENOG4108IHU transport system permease protein HRD68_RS15015 ENOG4105E0A ABC, transporter HRD68_RS15030 ENOG4105VUF Transcriptional regulator HRD68_RS15045 ENOG4105KME endoribonuclease L-psp HRD68_RS15050 ENOG4105KR8 Inherit from COG: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) HRD68_RS15115 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) HRD68_RS15120 ENOG4108Z1B Cyclase dehydrase HRD68_RS15130 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HRD68_RS15135 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) HRD68_RS15140 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) HRD68_RS15145 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ HRD68_RS15150 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) HRD68_RS15155 ENOG4108VKA Acts as a radical domain for damaged PFL and possibly other radical proteins (By similarity) HRD68_RS15160 ENOG4105C1J atp-dependent rna helicase HRD68_RS15165 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) HRD68_RS15170 ENOG4108IYU L-aspartate oxidase HRD68_RS15185 ENOG4105VQK sigma E regulatory protein, MucB RseB HRD68_RS15190 ENOG4105WMJ Positive regulator of sigma E, RseC MucC HRD68_RS15205 ENOG4105C3F Signal peptidase i HRD68_RS15220 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) HRD68_RS15225 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) HRD68_RS15230 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) HRD68_RS15235 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding HRD68_RS15240 ENOG4106G6Q Transcriptional regulator HRD68_RS15245 ENOG4105HYY HAD superfamily (Subfamily IF) hydrolase, YfhB HRD68_RS15250 ENOG4108Z6B deaminase HRD68_RS15255 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) HRD68_RS15270 ENOG4107WP9 Histidine kinase HRD68_RS15275 ENOG4108SKK alpha helix protein HRD68_RS15280 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HRD68_RS15285 ENOG4105C4K Nad synthetase HRD68_RS15290 ENOG4108YZA Nitrogen regulatory protein pii HRD68_RS15295 ENOG4106M0N transport system permease protein HRD68_RS15300 ENOG4105MUZ Protein of unknown function DUF2620 HRD68_RS15305 ENOG41080QX K07048 phosphotriesterase-related protein HRD68_RS15310 ENOG4108626 Racemase HRD68_RS15315 ENOG4105RMW regulation of transcription, DNA-dependent HRD68_RS15320 ENOG4108M21 HRD68_RS15325 ENOG4108EGH Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HRD68_RS15335 ENOG4105D8G Major Facilitator superfamily HRD68_RS15340 ENOG4108MN2 Stationary phase inducible protein CsiE HRD68_RS15345 ENOG41065CD Exported protein HRD68_RS15350 ENOG4105D7X high-affinity nickel-transporter HRD68_RS15355 ENOG4105ECY inositol monophosphatase HRD68_RS15360 ENOG4105CVS RNA methyltransferase TrmH family, group 1 HRD68_RS15365 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family HRD68_RS15375 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins HRD68_RS15385 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) HRD68_RS15390 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB HRD68_RS15395 ENOG4108ZIT Ferredoxin, 2FE-2S HRD68_RS15400 ENOG4105WVQ Fe-S assembly protein IscX HRD68_RS15410 ENOG4105YYA enhanced serine sensitivity protein SseB HRD68_RS15415 ENOG4108MGN ATP-binding component of a transport system HRD68_RS15420 ENOG4105DN3 alpha-2-macroglobulin domain protein HRD68_RS15425 ENOG4108JQB penicillin-binding protein 1C HRD68_RS15450 ENOG4105HSZ Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity) HRD68_RS15465 ENOG4105N21 Membrane HRD68_RS15470 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HRD68_RS15475 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) HRD68_RS15485 ENOG4105VPD cellular component movement HRD68_RS15490 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HRD68_RS15495 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HRD68_RS15500 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HRD68_RS15510 ENOG4108TC1 Transcriptional regulator HRD68_RS15535 ENOG4106JJN Part of the elfADCG-ycbUVF fimbrial operon, which promotes adhesion of bacteria to different abiotic surfaces. Could be required for the biogenesis of the ElfA fimbriae HRD68_RS15545 ENOG4108NAE Fimbrial chaperone protein HRD68_RS15550 ENOG4108AF8 Chaperone HRD68_RS15555 ENOG4105CW0 outer membrane usher protein HRD68_RS15565 ENOG4105DWF phosphomethylpyrimidine kinase HRD68_RS15575 ENOG4108ZGU inhibitor of vertebrate lysozyme HRD68_RS15585 ENOG410804X Transcriptional regulator HRD68_RS15590 ENOG4105J92 DNA-binding transcriptional activator GutM HRD68_RS15595 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase HRD68_RS15600 ENOG4105VI0 Pts system, glucitol sorbitol-specific HRD68_RS15605 ENOG4105DZY Pts system, glucitol sorbitol-specific HRD68_RS15610 ENOG410787A Pts system, glucitol sorbitol-specific HRD68_RS15615 ENOG4107TE5 Lipid kinase HRD68_RS15620 ENOG4105CFP Peptidase U32 HRD68_RS15625 ENOG4105KWI UPF0339 protein HRD68_RS15630 ENOG4105E3W Two component transcriptional regulator (Winged helix family HRD68_RS15635 ENOG4105EB3 Histidine kinase HRD68_RS15640 ENOG4105C0R drug resistance transporter emrb qaca subfamily HRD68_RS15645 ENOG4105BZS acriflavin resistance protein HRD68_RS15655 ENOG4105ENT Efflux transporter rnd family, mfp subunit HRD68_RS15665 ENOG4105CW0 outer membrane usher protein HRD68_RS15670 ENOG4108VCD Chaperone HRD68_RS15680 ENOG4105R8A Heat shock protein HRD68_RS15685 ENOG4105BZU Histidine kinase HRD68_RS15690 ENOG4105CJW magnesium transporter HRD68_RS15700 ENOG4105C9X ppx gppa phosphatase HRD68_RS15705 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) HRD68_RS15710 ENOG4105C8U phosphate abc transporter HRD68_RS15715 ENOG4105E2Z phosphate ABC transporter (Permease HRD68_RS15725 ENOG4108MK9 spermidine N(1)-acetyltransferase HRD68_RS15730 ENOG4108V3E phosphoribosylglycinamide formyltransferase HRD68_RS15740 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) HRD68_RS15745 ENOG4105C2W permease HRD68_RS15750 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) HRD68_RS15755 ENOG4105K89 arsenate reductase HRD68_RS15760 ENOG4105ERG peptidase m48, ste24p HRD68_RS15765 ENOG4105C02 permease HRD68_RS15770 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HRD68_RS15775 ENOG4105RH4 Glycine cleavage system transcriptional repressor HRD68_RS15780 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HRD68_RS15785 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HRD68_RS15790 ENOG4105C8V SAICAR synthetase HRD68_RS15795 ENOG4105CGZ zinc metallopeptidase HRD68_RS15800 ENOG4108VMM UPF0756 membrane protein HRD68_RS15805 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) HRD68_RS15810 ENOG4106KED esterase YpfH HRD68_RS15815 ENOG4105XYK UPF0370 protein HRD68_RS15825 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) HRD68_RS15830 ENOG4105KUZ arsenate reductase HRD68_RS15835 ENOG4105DDW LysR family Transcriptional regulator HRD68_RS15840 ENOG4105PFC Transcriptional regulator HRD68_RS15855 ENOG4107Z33 ABC transporter, permease HRD68_RS15860 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HRD68_RS15865 ENOG4105BZS acriflavin resistance protein HRD68_RS15875 ENOG4105WH1 Two component transcriptional regulator luxr family HRD68_RS15880 ENOG4108ZNS ferredoxin-type protein NapF HRD68_RS15885 ENOG41061Q0 Assembly protein for periplasmic nitrate reductase HRD68_RS15890 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) HRD68_RS15895 ENOG4108ZMS Electron transfer subunit of the periplasmic nitrate reductase complex NapAB (By similarity) HRD68_RS15900 ENOG4105CUW cytochrome C-TYPE protein HRD68_RS15905 ENOG4107VIJ nudix hydrolase HRD68_RS15910 ENOG4105C6K Malic enzyme HRD68_RS15920 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) HRD68_RS15925 ENOG4108R6G acetyltransferase HRD68_RS15930 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HRD68_RS15935 ENOG4105C2J ABC transporter HRD68_RS15940 ENOG4105CNN ABC, transporter HRD68_RS15945 ENOG4108NQD HRD68_RS15960 ENOG4105KHC sulfurtransferase HRD68_RS15965 ENOG4105CHR reductase HRD68_RS15970 ENOG4105H4F exported protein HRD68_RS15975 ENOG4105E7K (LipO)protein HRD68_RS15980 ENOG4105EZR dyp-type peroxidase family protein HRD68_RS16000 ENOG4108R66 Conserved Protein HRD68_RS16005 ENOG4105QEK Transcriptional regulator HRD68_RS16015 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein HRD68_RS16020 ENOG4108I5D sulfate abc transporter HRD68_RS16025 ENOG4105ECW sulfate abc transporter HRD68_RS16035 ENOG4105C6T cysteine synthase HRD68_RS16040 ENOG4105ECX polysaccharide export HRD68_RS16045 ENOG4107V1M polysaccharide export protein HRD68_RS16050 ENOG4105E12 capsule polysaccharide HRD68_RS16055 ENOG41084CK capsule polysaccharide HRD68_RS16060 ENOG4105K64 Glycosyl transferase, family 2 HRD68_RS16080 ENOG41090SZ ABC-2 type transporter HRD68_RS16090 ENOG4105DJY efflux transporter, rnd family, mfp subunit HRD68_RS16095 ENOG4105E3W Two component transcriptional regulator (Winged helix family HRD68_RS16100 ENOG4105E0F Histidine kinase HRD68_RS16105 ENOG4105C5Y PTS System HRD68_RS16110 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HRD68_RS16120 ENOG4105C6T cysteine synthase HRD68_RS16125 ENOG4105EXN Sulfate transport protein CysZ HRD68_RS16135 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) HRD68_RS16140 ENOG4105VRT cytoplasmic protein HRD68_RS16165 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) HRD68_RS16200 ENOG4105D9N nucleoside HRD68_RS16210 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) HRD68_RS16220 ENOG4105CPC Aldo Keto reductase HRD68_RS16225 ENOG4107RA9 decarboxylase HRD68_RS16230 ENOG4105C5Q Transcriptional regulator HRD68_RS16240 ENOG4105CHC glucokinase (EC 2.7.1.2) HRD68_RS16245 ENOG4105W2W Cytotoxic translational repressor of toxin-antitoxin stability system HRD68_RS16255 ENOG4105FCD Major Facilitator HRD68_RS16260 ENOG4105DY9 regulatoR HRD68_RS16265 ENOG4108HRK Histidine kinase HRD68_RS16270 ENOG41072TH Protein of unknown function (DUF1479) HRD68_RS16280 ENOG4105CHM Aminotransferase HRD68_RS16285 ENOG4108VKM cytochrome b561 HRD68_RS16295 ENOG4105PF0 Antitoxin component of a toxin-antitoxin (TA) module. Functions as an mRNA interferase antitoxin HRD68_RS16315 ENOG4108TGR phosphatase HRD68_RS16320 ENOG4106B0W Curli production assembly transport component CsgG HRD68_RS16330 ENOG4107Y60 (LipO)protein HRD68_RS16345 ENOG4107KGK dmso reductase anchor subunit HRD68_RS16350 ENOG4105QAX Iron-sulfur HRD68_RS16355 ENOG4107QY8 reductase HRD68_RS16370 ENOG4105CVE Lytic murein transglycosylase HRD68_RS16375 ENOG4105CUB amino acid HRD68_RS16400 ENOG4105DHJ ABC, transporter HRD68_RS16415 ENOG4105DS1 cytochrome b561 HRD68_RS16420 ENOG4108YYC ycei family HRD68_RS16425 ENOG4105DDV Transcriptional regulator (LacI family HRD68_RS16430 ENOG4105C5Y PTS System HRD68_RS16435 ENOG4105CS2 ec 3.2.1.21 HRD68_RS16445 ENOG4105NTW Transcriptional regulator HRD68_RS16450 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA HRD68_RS16455 ENOG4105HMZ Methyltransferase HRD68_RS16460 ENOG4105CVK Glutamate decarboxylase HRD68_RS16465 ENOG4105E5D amino acid HRD68_RS16480 ENOG41081FY multiple antibiotic resistance (MarC)-related HRD68_RS16490 ENOG4105BZU Histidine kinase HRD68_RS16495 ENOG4108WQH regulatoR HRD68_RS16500 ENOG41076YT nitrate reductase, gamma subunit HRD68_RS16505 ENOG4105R3A Nitrate reductase HRD68_RS16510 ENOG4108IUE nitrate reductase beta subunit HRD68_RS16515 ENOG4105CRU nitrate reductase, alpha subunit HRD68_RS16520 ENOG4105DQQ Major facilitator superfamily MFS_1 HRD68_RS16525 ENOG4105WH1 Two component transcriptional regulator luxr family HRD68_RS16530 ENOG4105CUW cytochrome C-TYPE protein HRD68_RS16535 ENOG4108J2R molybdopterin oxidoreductase HRD68_RS16675 ENOG4105CDU Replicative dna helicase HRD68_RS16740 ENOG4105QFS Lysis protein S homolog from lambdoid prophage HRD68_RS16910 ENOG4105DFP Integrase HRD68_RS16920 ENOG4105S64 Formate nitrite transporter HRD68_RS16930 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) HRD68_RS16935 ENOG41060IM Heme exporter protein HRD68_RS16940 ENOG4105X3C heme exporter protein HRD68_RS16945 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) HRD68_RS16950 ENOG4105DA4 cytochrome c-type biogenesis protein HRD68_RS16955 ENOG4107QX9 Thiol disulfide interChange protein HRD68_RS16960 ENOG4105KWW Biogenesis protein HRD68_RS16965 ENOG4105KWW Biogenesis protein HRD68_RS16970 ENOG410903C (LipO)protein HRD68_RS16985 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation HRD68_RS16990 ENOG4105KZW UPF0381 protein HRD68_RS16995 ENOG4105CHU acetyl-coa acetyltransferase HRD68_RS17000 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HRD68_RS17005 ENOG4108BY2 phosphohistidine phosphatase HRD68_RS17015 ENOG4108DG9 Smr protein MutS2 HRD68_RS17020 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) HRD68_RS17030 ENOG4105HPZ Involved in the removal of murein from the sacculus. May also facilitate integration of nascent murein strands into the sacculus by cleaving the peptide bonds between neighboring strands in mature murein (By similarity) HRD68_RS17035 ENOG4105EJ9 Membrane HRD68_RS17040 ENOG4108BPE -transporting atpase HRD68_RS17045 ENOG4105MH2 YfcL protein HRD68_RS17050 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) HRD68_RS17055 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HRD68_RS17070 ENOG4105D6F Phosphatase HRD68_RS17075 ENOG4105F4P )-transporter HRD68_RS17080 ENOG4106WZ1 flagella biosynthesis regulator HRD68_RS17090 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) HRD68_RS17100 ENOG4105N2G alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HRD68_RS17125 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HRD68_RS17135 ENOG4105DQR SNARE associated Golgi HRD68_RS17140 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) HRD68_RS17145 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase HRD68_RS17150 ENOG4108S3P Sporulation domain protein HRD68_RS17155 ENOG4105E96 Colicin v production protein HRD68_RS17160 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase HRD68_RS17165 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HRD68_RS17170 ENOG4105E89 ABC transporter HRD68_RS17175 ENOG4105DSP amino acid AbC transporter HRD68_RS17180 ENOG4106YG3 ABC transporter HRD68_RS17185 ENOG4108JEH abc transporter atp-binding protein HRD68_RS17190 ENOG4105ECP epimerase HRD68_RS17200 ENOG4108RE9 Phosphodiesterase HRD68_RS17205 ENOG4105PTV Nudix Hydrolase HRD68_RS17210 ENOG4108K4B hydrolase HRD68_RS17215 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) HRD68_RS17225 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) HRD68_RS17230 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HRD68_RS17235 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HRD68_RS17250 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) HRD68_RS17255 ENOG4105VYA Uncharacterized conserved protein (DUF2132) HRD68_RS17260 ENOG4105CHW UPF0052 protein HRD68_RS17265 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HRD68_RS17270 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HRD68_RS17275 ENOG4105M00 molybdopterin converting factor, subunit 1 HRD68_RS17280 ENOG4108ZAF Molybdopterin HRD68_RS17285 ENOG4105HFZ Membrane HRD68_RS17290 ENOG4105E0K tonB-dependent siderophore receptor HRD68_RS17305 ENOG4105CEY Amp-dependent synthetase and ligase HRD68_RS17310 ENOG4105E8G Major facilitator Superfamily HRD68_RS17315 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein HRD68_RS17320 ENOG4105E4F Isochorismate synthase HRD68_RS17325 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase HRD68_RS17330 ENOG4105WQI isochorismatase HRD68_RS17335 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase HRD68_RS17340 ENOG4107QWP ABC-2 type transporter HRD68_RS17345 ENOG4107QWP ABC-2 type transporter HRD68_RS17350 ENOG4105CJ1 ABC, transporter HRD68_RS17355 ENOG4105D0S secretion protein (HlyD HRD68_RS17360 ENOG4107MVR Transcriptional regulator HRD68_RS17365 ENOG4105C1J atp-dependent rna helicase HRD68_RS17370 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) HRD68_RS17380 ENOG41061WM D-Alanyl-D-Alanine HRD68_RS17385 ENOG4105CXG d-lactate dehydrogenase HRD68_RS17395 ENOG4105N1F Hnh endonuclease HRD68_RS17405 ENOG4105Y3U Transglycosylase-associated protein HRD68_RS17415 ENOG4105EHI Phosphonate ABC transporter, periplasmic HRD68_RS17430 ENOG4108W15 Protein of unknown function (DUF1456) HRD68_RS17435 ENOG4107TSX ABC branched chain amino acid family transporter periplasmic ligand binding protein HRD68_RS17440 ENOG4105C32 Amino acid ABC transporter (Permease) HRD68_RS17445 ENOG4105CNN ABC, transporter HRD68_RS17455 ENOG4108IV0 ABC, transporter HRD68_RS17460 ENOG4105KHC sulfurtransferase HRD68_RS17475 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system HRD68_RS17480 ENOG4107T5X Binding-protein-dependent transport systems, inner membrane component HRD68_RS17485 ENOG4108IJ8 ABC transporter HRD68_RS17490 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component HRD68_RS17500 ENOG4105D5Q Arginine ornithine antiporter HRD68_RS17505 ENOG4105CXN decarboxylase HRD68_RS17515 ENOG4105FDR Membrane HRD68_RS17525 ENOG4105DVT helicase HRD68_RS17530 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HRD68_RS17535 ENOG4108MTB glycosyl transferase family HRD68_RS17545 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction HRD68_RS17550 ENOG4107XC4 flavin reductase domain protein, FMN-binding HRD68_RS17555 ENOG4105EBA Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity) HRD68_RS17560 ENOG4107SDU Methyl-accepting chemotaxis HRD68_RS17565 ENOG4105CDA abc transporter atp-binding protein HRD68_RS17570 ENOG4105E5Q amino acid AbC transporter HRD68_RS17575 ENOG4107R0W ABC transporter HRD68_RS17580 ENOG4105KSC Transcriptional regulator, TraR DksA family HRD68_RS17585 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction HRD68_RS17590 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) HRD68_RS17620 ENOG4108T1M outer membrane protein x HRD68_RS17640 ENOG4105C5H ABC transporter HRD68_RS17645 ENOG4105D06 uba thif-type nad fad binding protein HRD68_RS17650 ENOG4105CVM Molybdenum cofactor synthesis domain protein HRD68_RS17660 ENOG4105CSH Transporter HRD68_RS17675 ENOG4105EGI Transcriptional regulator HRD68_RS17680 ENOG4105CBP Major Facilitator HRD68_RS17685 ENOG4105EUJ GTP cyclohydrolase i HRD68_RS17690 ENOG4105DHF Membrane HRD68_RS17695 ENOG41060NJ transcriptional regulator HRD68_RS17710 ENOG4107SDZ Galactoside transport system permease protein mglC HRD68_RS17715 ENOG4105TMB Formate nitrite transporter HRD68_RS17720 ENOG4108JUA Transcriptional regulator HRD68_RS17725 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) HRD68_RS17730 ENOG4108RC0 Electron transport protein HRD68_RS17735 ENOG4108MG9 hydrogenase 3 maturation protease HRD68_RS17740 ENOG4105I6X formate hydrogenlyase maturation HRD68_RS17745 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit HRD68_RS17755 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HRD68_RS17760 ENOG4108JPZ Monovalent cation H antiporter subunit D HRD68_RS17765 ENOG4107WQX hydrogenase 4 membrane subunit HRD68_RS17770 ENOG4105D65 subunit l HRD68_RS17775 ENOG4107TDF Formate hydrogenlyase subunit 4 HRD68_RS17780 ENOG4108JPZ Monovalent cation H antiporter subunit D HRD68_RS17785 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) HRD68_RS17790 ENOG410816D Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) HRD68_RS17800 ENOG4107GZ4 SanA protein HRD68_RS17805 ENOG4107R1I NAD-dependent malic enzyme HRD68_RS17815 ENOG41067MG lrgb family HRD68_RS17820 ENOG4105VAW lrga family HRD68_RS17825 ENOG4105E5W Transporter HRD68_RS17840 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) HRD68_RS17845 ENOG4105D1F ATP-binding protein HRD68_RS17860 ENOG4108GAE asmA family HRD68_RS17865 ENOG4105CEE C4-dicarboxylate transporter HRD68_RS17870 ENOG4105EE5 Membrane protein terC HRD68_RS17890 ENOG4105EY8 ABC transporter HRD68_RS17895 ENOG4108KQJ Type 11 methyltransferase HRD68_RS17905 ENOG4105C0K Gdp-mannose 4,6-dehydratase HRD68_RS17910 ENOG4108DMA Nad-dependent epimerase dehydratase HRD68_RS17925 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HRD68_RS17930 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HRD68_RS17935 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) HRD68_RS17940 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase HRD68_RS17945 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) HRD68_RS17950 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HRD68_RS17960 ENOG4105ECC imidazole-glycerol-phosphate dehydratase HRD68_RS17965 ENOG4105CIH Imidazole acetol-phosphate transaminase HRD68_RS17970 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) HRD68_RS17975 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) HRD68_RS17985 ENOG4107SRH Nad-dependent epimerase dehydratase HRD68_RS17990 ENOG4105CNN ABC, transporter HRD68_RS17995 ENOG4105C2J ABC transporter HRD68_RS18000 ENOG4107SCQ Iron-containing alcohol dehydrogenase HRD68_RS18005 ENOG4105CUB amino acid HRD68_RS18010 ENOG4105CJB Exodeoxyribonuclease I HRD68_RS18020 ENOG4105DR8 Membrane HRD68_RS18025 ENOG41090HJ UPF0265 protein HRD68_RS18035 ENOG4105CNN ABC, transporter HRD68_RS18045 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HRD68_RS18050 ENOG4105JZC GHMP kinase HRD68_RS18055 ENOG4107QZB decarboxylase HRD68_RS18060 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HRD68_RS18065 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HRD68_RS18070 ENOG4105KTW ethanolamine utilization protein HRD68_RS18075 ENOG4105M3W utilization protein HRD68_RS18085 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) HRD68_RS18095 ENOG4108EKI Dehydrogenase HRD68_RS18105 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml HRD68_RS18115 ENOG4108VPX Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate (By similarity) HRD68_RS18125 ENOG4105KNY Microcompartments protein HRD68_RS18135 ENOG41084PW diol glycerol dehydratase reactivating factor large subunit HRD68_RS18140 ENOG4108ZFT Dehydratase small subunit HRD68_RS18145 ENOG4105YCI dehydratase medium subunit HRD68_RS18150 ENOG4105DMB glycerol dehydratase HRD68_RS18155 ENOG4105EHR propanediol utilization protein pduB HRD68_RS18160 ENOG4105KNY Microcompartments protein HRD68_RS18165 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HRD68_RS18170 ENOG4107XVH Transcriptional regulator HRD68_RS18175 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) HRD68_RS18180 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) HRD68_RS18185 ENOG41081F0 Precorrin-8x methylmutase HRD68_RS18190 ENOG4105EE8 May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity) HRD68_RS18195 ENOG4108DR9 Cobalt-precorrin-6Y C(5)-methyltransferase HRD68_RS18200 ENOG4107XSI cobalt-precorrin-6y C15-methyltransferase HRD68_RS18205 ENOG4105CIA precorrin-4 C(11)-methyltransferase HRD68_RS18210 ENOG4108P62 biosynthesis protein (CbiG) HRD68_RS18215 ENOG4105E4R Precorrin-3B C17-methyltransferase HRD68_RS18220 ENOG4105QUC reductase HRD68_RS18225 ENOG4107PPM cobalt chelatase HRD68_RS18230 ENOG4105DVK Precorrin-2 c20-methyltransferase HRD68_RS18235 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) HRD68_RS18240 ENOG4105W4R Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) HRD68_RS18245 ENOG4108V4M Cobalt abc transporter HRD68_RS18255 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) HRD68_RS18260 ENOG4108YZT Adenosylcobinamide kinase HRD68_RS18265 ENOG4108UHF Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) HRD68_RS18270 ENOG4108TGR phosphatase HRD68_RS18275 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) HRD68_RS18280 ENOG4105CN8 Transcriptional regulator HRD68_RS18290 ENOG4107U5R The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) HRD68_RS18295 ENOG4105EAA nucleoside HRD68_RS18300 ENOG4105CDH Citrulline--aspartate ligase HRD68_RS18305 ENOG4105UQX Mate efflux family protein HRD68_RS18315 ENOG4105EMU Dehydrogenase HRD68_RS18320 ENOG4108KSB HipA-like N-terminal domain HRD68_RS18325 ENOG4105MHH HipA N-terminal domain protein HRD68_RS18365 ENOG4105FE9 pseudouridine synthase HRD68_RS18370 ENOG4108MQF Chaperone HRD68_RS18385 ENOG4105GQR Chaperone HRD68_RS18395 ENOG4105BZU Histidine kinase HRD68_RS18400 ENOG4108Q9V regulatoR HRD68_RS18410 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HRD68_RS18415 ENOG4107RCV ABC transporter, permease HRD68_RS18420 ENOG4105C4Y ABC transporter HRD68_RS18425 ENOG4105CXY transporter HRD68_RS18430 ENOG4105BZU Histidine kinase HRD68_RS18435 ENOG4108KX4 response regulator HRD68_RS18440 ENOG4106YYS transcriptional regulatory protein HRD68_RS18445 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HRD68_RS18450 ENOG4105DUA (citrate (pro-3S)-lyase ligase HRD68_RS18455 ENOG4105XGS Covalent carrier of the coenzyme of citrate lyase (By similarity) HRD68_RS18460 ENOG4105CI0 Citrate lyase HRD68_RS18465 ENOG4105CHY citrate lyase, alpha HRD68_RS18475 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase HRD68_RS18480 ENOG4107QPK )-transporter HRD68_RS18485 ENOG4108TSE Transferase HRD68_RS18495 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) HRD68_RS18500 ENOG4108P2H Inner membrane protein YjiG HRD68_RS18505 ENOG41074DU domain protein HRD68_RS18515 ENOG4107QPK )-transporter HRD68_RS18520 ENOG4105JSC dimethylmenaquinone methyltransferase HRD68_RS18530 ENOG4107F9Y LysR family transcriptional regulator HRD68_RS18540 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme HRD68_RS18545 ENOG4105D3G Pseudouridine synthase HRD68_RS18595 ENOG4108YS1 cytoplasmic protein HRD68_RS18605 ENOG4105EW9 transcriptional regulator AsnC family HRD68_RS18620 ENOG4105CBN LysR family transcriptional regulator HRD68_RS18650 ENOG4105EXZ Involved in the regulation of ptsG expression by binding and inactivating Mlc (By similarity) HRD68_RS18655 ENOG4105D6F Phosphatase HRD68_RS18660 ENOG41061EV selenium-binding protein YdfZ HRD68_RS18670 ENOG4105J0Q Transcriptional regulator HRD68_RS18675 ENOG4105GSJ Inner membrane protein ylaC HRD68_RS18685 ENOG4105CNT hydrolase family 2 HRD68_RS18690 ENOG4105ETE Transcriptional regulator (LacI family HRD68_RS18700 ENOG4105VZF DsrB protein HRD68_RS18705 ENOG4105C8Q Methyl-accepting chemotaxis HRD68_RS18710 ENOG4105KT7 mgtC SapB transporter HRD68_RS18715 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic HRD68_RS18720 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein HRD68_RS18725 ENOG4108VA4 Universal stress protein HRD68_RS18735 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region HRD68_RS18740 ENOG4107RD7 Flagellar Motor Protein, MotA HRD68_RS18745 ENOG4105ER2 Ompa motb domain protein HRD68_RS18750 ENOG4105CBS Chea signal transduction histidine kinase HRD68_RS18755 ENOG4108V3W Chemotaxis protein, CheW HRD68_RS18760 ENOG4105C8Q Methyl-accepting chemotaxis HRD68_RS18765 ENOG4105C8Q Methyl-accepting chemotaxis HRD68_RS18770 ENOG4105BZU Histidine kinase HRD68_RS18780 ENOG4108VYJ response regulator receiver protein HRD68_RS18785 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) HRD68_RS18790 ENOG4105D00 flagellar biosynthetic protein flhB HRD68_RS18795 ENOG4105D7B Flagellar biosynthesis protein flha HRD68_RS18800 ENOG4105W13 flagellar protein HRD68_RS18810 ENOG4105QVD Flagella synthesis protein FlgN HRD68_RS18815 ENOG4105M9M anti-sigma28 factor FlgM HRD68_RS18820 ENOG4105CKS Flagella basal body P-ring formation protein flgA HRD68_RS18825 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) HRD68_RS18830 ENOG4108ZC9 flagellar basal-body rod protein flgc HRD68_RS18835 ENOG4105W00 Flagellar hook capping protein HRD68_RS18840 ENOG4105BZE flagellar hook protein, FlgE HRD68_RS18845 ENOG4108KPB Flagellar basal-body rod protein FlgF HRD68_RS18850 ENOG4105CGA flagellar basal-body rod protein FlgG HRD68_RS18865 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj HRD68_RS18870 ENOG4105E1Q flagellar hook-associated protein HRD68_RS18875 ENOG4105DTJ flagellar hook-associated protein HRD68_RS18880 ENOG4105D19 Role in flagellar biosynthesis (By similarity) HRD68_RS18885 ENOG4105VS8 Flagellar biosynthetic protein fliq HRD68_RS18890 ENOG4105CN7 Flagellar biosynthetic protein FliP HRD68_RS18900 ENOG4105DD5 Flagellar motor switch protein HRD68_RS18905 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HRD68_RS18910 ENOG4107ZI8 flagellar basal body-associated protein flil HRD68_RS18915 ENOG4105WF4 Flagellar hook-length control protein HRD68_RS18920 ENOG4105GSA Flagellar export protein flij HRD68_RS18925 ENOG4108JIR Flagellum-specific ATP synthase HRD68_RS18930 ENOG41090PJ Flagellar assembly protein HRD68_RS18935 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HRD68_RS18940 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) HRD68_RS18945 ENOG4105VQ0 flagellar hook-basal body complex protein fliE HRD68_RS18955 ENOG4105DHT Metal Dependent Phosphohydrolase HRD68_RS18960 ENOG4108NKV transcriptional regulator HRD68_RS18965 ENOG4105YXP it directly binds FlhC, thus inhibiting the binding of the FlhC FlhD complex to class 2 promoters, resulting in decreased expression of class 2 flagellar operons. As a chaperone, effects FliD transition to the membrane by preventing its premature polymerization, and by directing it to the export apparatus (By similarity) HRD68_RS18970 ENOG4105MQ3 flagellar protein FliS HRD68_RS18975 ENOG4105DTS flagellar hook-associated HRD68_RS18985 ENOG4108C80 FliB family HRD68_RS18990 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HRD68_RS18995 ENOG4108M9K flagella biosynthesis protein FliZ HRD68_RS19000 ENOG4105K6H D-cysteine desulfhydrase HRD68_RS19005 ENOG4105EAB amino acid AbC transporter HRD68_RS19010 ENOG4105E5Q amino acid AbC transporter HRD68_RS19015 ENOG4105CDA abc transporter atp-binding protein HRD68_RS19030 ENOG4105C26 Dehydrogenase HRD68_RS19035 ENOG4105CK7 Sodium proline symporter HRD68_RS19040 ENOG4105EKT )-iron permease HRD68_RS19045 ENOG410650H (LipO)protein HRD68_RS19065 ENOG4108MX5 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses (By similarity) HRD68_RS19070 ENOG4105C2W permease HRD68_RS19075 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) HRD68_RS19080 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) HRD68_RS19085 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) HRD68_RS19090 ENOG4107YYT May reduce aminoacrylate peracid to aminoacrylate. Required to remove a toxic intermediate produce by the pyrimidine nitrogen degradation (By similarity) HRD68_RS19095 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) HRD68_RS19100 ENOG4105EQP Catalyzes the pyrimidine ring opening between N-3 and C- 4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate (By similarity) HRD68_RS19105 ENOG4108R86 Transcriptional regulator HRD68_RS19120 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) HRD68_RS19135 ENOG4105E5K Alpha-amylase HRD68_RS19145 ENOG4105RA2 Membrane HRD68_RS19150 ENOG4105XVG cytoplasmic protein HRD68_RS19155 ENOG4105WH1 Two component transcriptional regulator luxr family HRD68_RS19160 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) HRD68_RS19165 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase HRD68_RS19195 ENOG4108R7K Metal Dependent Phosphohydrolase HRD68_RS19215 ENOG4108S1U HRD68_RS19225 ENOG4105CAR Terminase, large subunit HRD68_RS19235 ENOG4108ZUE Phage regulatory protein rha HRD68_RS19240 ENOG4108MXB Protein of unknown function (DUF968) HRD68_RS19255 ENOG4105NVB glycoside hydrolase, family 19 HRD68_RS19295 ENOG4105EFC phage portal protein HK97 family HRD68_RS19425 ENOG4105CEE C4-dicarboxylate transporter HRD68_RS19430 ENOG4108Q3X Transcriptional regulator HRD68_RS19435 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase HRD68_RS19465 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor HRD68_RS19480 ENOG4105ECR NmrA family HRD68_RS19485 ENOG4105KVH Transcriptional regulator HRD68_RS19500 ENOG4107QZW Altronate oxidoreductase HRD68_RS19505 ENOG4105CPQ Dehydrogenase HRD68_RS19510 ENOG410617M Transcriptional regulator HRD68_RS19515 ENOG4108I5G Major Facilitator superfamily HRD68_RS19520 ENOG4105DWP Membrane HRD68_RS19525 ENOG4105ECQ AraC Family Transcriptional Regulator HRD68_RS19535 ENOG4105XXV Acid-resistance protein HRD68_RS19555 ENOG4105BZ1 (ABC) transporter HRD68_RS19560 ENOG4105D5Q Arginine ornithine antiporter HRD68_RS19575 ENOG4105N4N Protein of unknown function (DUF2766) HRD68_RS19580 ENOG4105TIK HRD68_RS19590 ENOG41064PC HRD68_RS19605 ENOG4105C85 amino acid HRD68_RS19610 ENOG41079UR PagP is required both for biosynthesis of hepta-acylated lipid A species containing palmitate and for resistance to cationic antimicrobial peptides (CAMPs). It catalyzes the transfer of a palmitate chain (16 0) from the sn-1 position of a glycerophospholipid to the free hydroxyl group of the (R)-3- hydroxymyristate chain at position 2 of lipid A (endotoxin) (By similarity) HRD68_RS19625 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase HRD68_RS19630 ENOG4105CJN penicillin-binding protein HRD68_RS19645 ENOG4105BZU Histidine kinase HRD68_RS19655 ENOG4108UI1 Probably functions as a manganese efflux pump (By similarity) HRD68_RS19665 ENOG4105F3R pts system mannose fructose sorbose family iid HRD68_RS19670 ENOG4105ETZ PTS System HRD68_RS19675 ENOG4105DAS pts system HRD68_RS19680 ENOG4105EE5 Membrane protein terC HRD68_RS19690 ENOG4105EJQ L-serine dehydratase HRD68_RS19695 ENOG4105P8F nudix hydrolase HRD68_RS19705 ENOG4105X5C UPF0181 protein HRD68_RS19710 ENOG4108EF9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR HRD68_RS19715 ENOG4105C1J atp-dependent rna helicase HRD68_RS19720 ENOG4105X2V dna damage-inducible protein HRD68_RS19735 ENOG4105CUG Oligopeptidase b HRD68_RS19740 ENOG4105UMD exodeoxyribonuclease X HRD68_RS19755 ENOG4105MPK DNA polymerase III subunit theta HRD68_RS19760 ENOG41090A1 ferritin HRD68_RS19765 ENOG4105FXM Copper resistance protein HRD68_RS19770 ENOG4108PNC copper resistance HRD68_RS19775 ENOG4105NKT exported protein HRD68_RS19785 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase HRD68_RS19825 ENOG4108SHQ Glutathione S-transferase HRD68_RS19845 ENOG4105WT8 Protein of unknown function (DUF1480) HRD68_RS19895 ENOG4105DY2 Paraquat-inducible protein b HRD68_RS19900 ENOG4105H2K paraquat-inducible protein a HRD68_RS19905 ENOG4108ZGC gaf domain protein HRD68_RS19910 ENOG41073DY may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity) HRD68_RS19915 ENOG4105CN1 protease HRD68_RS19920 ENOG4105D0M Protease HtpX homolog HRD68_RS19925 ENOG4105C0R drug resistance transporter emrb qaca subfamily HRD68_RS19930 ENOG4105CAZ oligogalacturonide lyase HRD68_RS19940 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase HRD68_RS19945 ENOG4108ETY sodium dicarboxylate symporter HRD68_RS19950 ENOG4107K5X Membrane-bound metal-dependent hydrolase HRD68_RS19955 ENOG4108PU9 oligogalacturonate-specific porin HRD68_RS19965 ENOG4108IJ9 (ABC) transporter HRD68_RS19970 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component HRD68_RS19975 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component HRD68_RS19980 ENOG41061NF Pectate lyase HRD68_RS19985 ENOG4105CHR reductase HRD68_RS19990 ENOG4105M5J Cupin 2, conserved barrel domain protein HRD68_RS19995 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 HRD68_RS20000 ENOG4107PN8 YfeABCD locus regulator HRD68_RS20010 ENOG4105CC5 ABC transporter HRD68_RS20015 ENOG4105CC5 ABC transporter HRD68_RS20020 ENOG4105DIK (ABC) transporter HRD68_RS20025 ENOG4105DSE periplasmic solute binding protein HRD68_RS20035 ENOG41082NP Multiple antibiotic resistance HRD68_RS20050 ENOG41064BZ L-xylulose 5-phosphate 3-epimerase HRD68_RS20055 ENOG4105H6Q decarboxylase HRD68_RS20060 ENOG4105CMG Carbohydrate kinase HRD68_RS20065 ENOG4105DG4 malate L-lactate dehydrogenase HRD68_RS20080 ENOG4105CNN ABC, transporter HRD68_RS20085 ENOG4105C2J ABC transporter HRD68_RS20090 ENOG4105J4Q Transcriptional regulator HRD68_RS20095 ENOG4108UQV Membrane HRD68_RS20100 ENOG41087WU HRD68_RS20105 ENOG4105VRE Pentapeptide repeat protein HRD68_RS20145 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) HRD68_RS20150 ENOG4105ED1 spovr family HRD68_RS20155 ENOG4105MWK D-amino acid dehydrogenase, small subunit HRD68_RS20160 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HRD68_RS20165 ENOG4105DHQ Histidine kinase HRD68_RS20170 ENOG4105XJC Two component transcriptional regulator (Winged helix family HRD68_RS20175 ENOG4105H4F exported protein HRD68_RS20180 ENOG4105CNH Multidrug resistance protein MdtL HRD68_RS20185 ENOG4105BZU Histidine kinase HRD68_RS20190 ENOG4105EUB pirin domain protein HRD68_RS20195 ENOG4105HEI LysR family (Transcriptional regulator HRD68_RS20205 ENOG4106AKX UPF0229 protein HRD68_RS20210 ENOG4105CYN Serine protein kinase HRD68_RS20215 ENOG4105GNX MltA-interacting MipA family protein HRD68_RS20220 ENOG4105DSB aldose 1-epimerase HRD68_RS20245 ENOG4105VUT cytoplasmic protein HRD68_RS20250 ENOG4108RWI nicotinamidase HRD68_RS20255 ENOG4105HDK L-asparaginase HRD68_RS20260 ENOG4105D07 Signal peptide peptidase, SppA HRD68_RS20265 ENOG41069NU Nitroreductase HRD68_RS20275 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HRD68_RS20280 ENOG4105MTM Protein of unknown function (DUF1496) HRD68_RS20285 ENOG4105M6F mutator MutT protein HRD68_RS20290 ENOG4105CGK Exodeoxyribonuclease III HRD68_RS20295 ENOG4105SKE transcriptional Regulator LysR family HRD68_RS20315 ENOG4105CIY formyltetrahydrofolate deformylase HRD68_RS20320 ENOG4105K5B UPF0225 protein HRD68_RS20330 ENOG4105D78 K07001 NTE family protein HRD68_RS20335 ENOG4105I93 response regulator HRD68_RS20340 ENOG4105C6Y Udp-glucose 6-dehydrogenase HRD68_RS20355 ENOG4105C0A alcohol dehydrogenase HRD68_RS20360 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein HRD68_RS20365 ENOG4108J59 Extracellular solute-binding protein, family 5 HRD68_RS20370 ENOG4107QSI ABC, transporter HRD68_RS20375 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HRD68_RS20380 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HRD68_RS20385 ENOG4105C3U ABC transporter HRD68_RS20390 ENOG4108JQ7 (ABC) transporter HRD68_RS20395 ENOG4108W5H UPF0263 protein HRD68_RS20400 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) HRD68_RS20410 ENOG4105CMB EAL domain-containing protein HRD68_RS20420 ENOG4105K9H YciI-like protein HRD68_RS20425 ENOG410822N TonB family HRD68_RS20430 ENOG4105NAU thioesterase Superfamily protein HRD68_RS20435 ENOG4107835 probably involved in intracellular septation (By similarity) HRD68_RS20445 ENOG4108S3I UPF0259 membrane protein HRD68_RS20450 ENOG4105EIF outer membrane protein W HRD68_RS20460 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) HRD68_RS20465 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) HRD68_RS20470 ENOG4105DK0 Indole-3-glycerol phosphate synthase HRD68_RS20480 ENOG4105DDQ anthranilate synthase HRD68_RS20495 ENOG4105DB7 PHP domain protein HRD68_RS20500 ENOG4107RTD sua5 ycio yrdc ywlc family protein HRD68_RS20510 ENOG4108Q9V regulatoR HRD68_RS20520 ENOG4105FE9 pseudouridine synthase HRD68_RS20525 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase HRD68_RS20530 ENOG4105UBK short-chain dehydrogenase reductase HRD68_RS20535 ENOG4105ERU peptidase HRD68_RS20540 ENOG4105RKX Protein of unknown function (DUF2498) HRD68_RS20545 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HRD68_RS20550 ENOG4107R11 Transcriptional regulator HRD68_RS20560 ENOG4107QM5 aconitate hydratase HRD68_RS20570 ENOG4105EYK Phosphatidylglycerophosphatase B HRD68_RS20575 ENOG4105Q4A inner membrane protein yciS HRD68_RS20580 ENOG4105CFV Tetratricopeptide repeat protein HRD68_RS20590 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction HRD68_RS20595 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) HRD68_RS20600 ENOG4108ZJT translation initiation factor, Sui1 HRD68_RS20605 ENOG41061RM osmotically inducible lipoprotein HRD68_RS20610 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase HRD68_RS20620 ENOG4105N2W Transcriptional regulator HRD68_RS20635 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HRD68_RS20640 ENOG4105VCD cytoplasmic protein HRD68_RS20645 ENOG4105D22 carbon starvation protein HRD68_RS20650 ENOG4108IEC Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity) HRD68_RS20655 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit HRD68_RS20660 ENOG4105CSM endonuclease III HRD68_RS20670 ENOG4108UQQ Electron transport complex HRD68_RS20680 ENOG4105UEI Transcriptional Regulator AraC Family HRD68_RS20695 ENOG4105DGN Electron transport complex HRD68_RS20700 ENOG4105M9B inner membrane protein ydgK HRD68_RS20705 ENOG4105CKU formyltetrahydrofolate synthetase HRD68_RS20720 ENOG4108JJA ABC, transporter HRD68_RS20725 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) HRD68_RS20730 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) HRD68_RS20740 ENOG4105DMK Periplasmic binding protein LacI transcriptional regulator HRD68_RS20745 ENOG4105C2J ABC transporter HRD68_RS20750 ENOG4105CNN ABC, transporter HRD68_RS20760 ENOG4105D9R oxidoreductase HRD68_RS20765 ENOG4105DHU Bile acid HRD68_RS20770 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) HRD68_RS20775 ENOG4105C87 Aminotransferase class I and II HRD68_RS20780 ENOG4105CI1 PTS System HRD68_RS20785 ENOG4107P2S Transcriptional regulator HRD68_RS20805 ENOG4106J39 exported protein HRD68_RS20810 ENOG4105EIP mannose-6-phosphate isomerase HRD68_RS20815 ENOG4105C9Q fumarate hydratase class II HRD68_RS20820 ENOG4105KR1 Trans-acting protein required for termination of DNA replication. Binds to DNA replication terminator sequences (terA to terF) to prevent the passage of replication forks. The termination efficiency will be affected by the affinity of this protein for the terminator sequence (By similarity) HRD68_RS20830 ENOG4105D94 Major Facilitator Superfamily HRD68_RS20835 ENOG4106NZI LysR family Transcriptional regulator HRD68_RS20840 ENOG4105DAG ROK family HRD68_RS20845 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HRD68_RS20855 ENOG4105KBG Protein of unknown function (DUF1161) HRD68_RS20860 ENOG4105M5Q UPF0482 protein HRD68_RS20865 ENOG4105KK4 UPF0060 membrane protein HRD68_RS20870 ENOG4105EMU Dehydrogenase HRD68_RS20875 ENOG4105C0R drug resistance transporter emrb qaca subfamily HRD68_RS20880 ENOG4105TDT uncharacterized protein yahO HRD68_RS20915 ENOG4105CYM Glutathione S-transferase HRD68_RS20925 ENOG4108RYR transcriptional regulator AsnC family HRD68_RS20935 ENOG4105DSP amino acid AbC transporter HRD68_RS20940 ENOG4105E89 ABC transporter HRD68_RS20945 ENOG4106V2I dimethylaminohydrolase HRD68_RS20950 ENOG4105FYV Amp nucleosidase HRD68_RS20975 ENOG4105CVK Glutamate decarboxylase HRD68_RS20980 ENOG4105E5D amino acid HRD68_RS20990 ENOG4105PAD Hydrolase HRD68_RS21025 ENOG4108S5C Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell (By similarity) HRD68_RS21040 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HRD68_RS21045 ENOG4105DS0 Transcriptional regulator, Crp Fnr family HRD68_RS21050 ENOG4105Q9Y Universal stress protein HRD68_RS21055 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HRD68_RS21060 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HRD68_RS21065 ENOG4105C5D exported protein HRD68_RS21070 ENOG4105D5Q Arginine ornithine antiporter HRD68_RS21080 ENOG4107EXC regulatoR HRD68_RS21085 ENOG4105JJR Histidine kinase HRD68_RS21090 ENOG4105CTD carboxy-peptidase HRD68_RS21100 ENOG4105CVW peptidase s1 and s6 chymotrypsin hap HRD68_RS21110 ENOG4105MRD Phage derived protein Gp49-like (DUF891) HRD68_RS21115 ENOG4105CQ7 ATP-dependent helicase HRD68_RS21120 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) HRD68_RS21125 ENOG4105CSH Transporter HRD68_RS21135 ENOG4105HVQ Regulatory factor of maltose metabolism HRD68_RS21145 ENOG4105DEI Mannitol dehydrogenase HRD68_RS21150 ENOG4105CMG Carbohydrate kinase HRD68_RS21155 ENOG4105IE8 Alpha-ketoglutarate permease HRD68_RS21160 ENOG4105WXT Conserved Protein HRD68_RS21165 ENOG410689M (LipO)protein HRD68_RS21170 ENOG4107H52 Dicarboxylate transport HRD68_RS21175 ENOG4105C5I Dehydrogenase HRD68_RS21180 ENOG4105IKK cytoplasmic protein HRD68_RS21190 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) HRD68_RS21195 ENOG4105CS2 ec 3.2.1.21 HRD68_RS21200 ENOG4105C5Y PTS System HRD68_RS21205 ENOG4105CID antiterminator HRD68_RS21210 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) HRD68_RS21220 ENOG4107QSI ABC, transporter HRD68_RS21225 ENOG4105KXI murein peptide amidase A HRD68_RS21230 ENOG4107S8C mandelate racemase muconate lactonizing HRD68_RS21235 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) HRD68_RS21255 ENOG4106K28 UPF0283 membrane protein HRD68_RS21260 ENOG4105CM6 amino acid regulated cytosolic protein HRD68_RS21270 ENOG4105FM1 phage shock protein C HRD68_RS21275 ENOG4105YYT phage shock protein B HRD68_RS21280 ENOG41087YS Phage shock protein A HRD68_RS21285 ENOG4105E51 psp operon transcriptional activator HRD68_RS21290 ENOG4108HIY periplasmic HRD68_RS21295 ENOG4108EKA peptide transport system, permease HRD68_RS21300 ENOG4108EU3 peptide transport system, permease HRD68_RS21305 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein HRD68_RS21310 ENOG4108JQ2 peptide transport system atp-binding protein HRD68_RS21315 ENOG4105Q4T oxidoreductase HRD68_RS21320 ENOG4105DUX Transporter HRD68_RS21335 ENOG41069YE inner membrane protein yohC HRD68_RS21340 ENOG4108ZR5 Conserved Protein HRD68_RS21345 ENOG4108K3A Glutathione S-transferase HRD68_RS21355 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) HRD68_RS21365 ENOG410642K Lysozyme inhibitor HRD68_RS21370 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) HRD68_RS21375 ENOG4108XTF Outer Membrane Lipoprotein HRD68_RS21380 ENOG4108US0 Transcription regulator that can specifically activate or repress expression of target genes (By similarity) HRD68_RS21390 ENOG4105Y49 secretion protein, HlyD family HRD68_RS21395 ENOG4105DSW Fusaric acid resistance protein HRD68_RS21400 ENOG4107RGM aldo keto reductase HRD68_RS21405 ENOG4105XZD Fe-S protein HRD68_RS21410 ENOG4105DIJ Phosphoethanolamine transferase HRD68_RS21415 ENOG4108WUH Transcriptional regulator, TetR family HRD68_RS21420 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HRD68_RS21425 ENOG4108UYE Lactoylglutathione lyase HRD68_RS21430 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) HRD68_RS21435 ENOG4105M2J Glutaredoxin HRD68_RS21440 ENOG4105K4H Nlp p60 protein HRD68_RS21445 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HRD68_RS21455 ENOG4105ETE Transcriptional regulator (LacI family HRD68_RS21460 ENOG4105F52 Transcriptional regulator HRD68_RS21465 ENOG4105CZQ inner membrane transport protein YdhC HRD68_RS21470 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HRD68_RS21475 ENOG4108R6K riboflavin synthase, subunit alpha HRD68_RS21480 ENOG4107QI1 Mate efflux family protein HRD68_RS21495 ENOG4105CA9 Pyruvate kinase HRD68_RS21505 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HRD68_RS21510 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) HRD68_RS21520 ENOG4105JRK feS assembly protein SufD HRD68_RS21525 ENOG4105C3K feS assembly ATPase SufC HRD68_RS21530 ENOG4105DIW FeS assembly protein SUFB HRD68_RS21535 ENOG4108Z4V iron-sulfur cluster assembly HRD68_RS21540 ENOG4105KA0 thioesterase Superfamily protein HRD68_RS21545 ENOG4105CQB FAD linked oxidase domain protein HRD68_RS21550 ENOG4105IPI Membrane HRD68_RS21560 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) HRD68_RS21565 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) HRD68_RS21570 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HRD68_RS21580 ENOG4107RMF Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes (By similarity) HRD68_RS21585 ENOG4108QBX (LipO)protein HRD68_RS21590 ENOG4105PE8 Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) HRD68_RS21600 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) HRD68_RS21605 ENOG4105F73 Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) HRD68_RS21615 ENOG4105CKK Glycosyl transferase, family 2 HRD68_RS21620 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HRD68_RS21625 ENOG41080WI Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system (By similarity) HRD68_RS21630 ENOG4108V06 Glutathione peroxidase HRD68_RS21635 ENOG4108ESU Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity) HRD68_RS21645 ENOG4107TT5 NLP P60 protein HRD68_RS21650 ENOG4105C05 Multifunctional regulator of fatty acid metabolism (By similarity) HRD68_RS21655 ENOG4105DKR Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) HRD68_RS21660 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) HRD68_RS21670 ENOG4108ZZ3 UPF0260 protein HRD68_RS21675 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase HRD68_RS21680 ENOG4105VNG YcgL domain-containing protein HRD68_RS21685 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) HRD68_RS21690 ENOG4107QMS site-determining protein HRD68_RS21695 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) HRD68_RS21700 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) HRD68_RS21705 ENOG4105CEY Amp-dependent synthetase and ligase HRD68_RS21710 ENOG4105Y4Z Outer Membrane Lipoprotein HRD68_RS21715 ENOG41072GX Peptidase M22 Glycoprotease HRD68_RS21720 ENOG4105DVT helicase HRD68_RS21725 ENOG4105M4H endoribonuclease L-psp HRD68_RS21735 ENOG41090TI Catalyzes the excretion of spermidine (By similarity) HRD68_RS21740 ENOG4108M1A Chitin-binding protein HRD68_RS21745 ENOG4108UHU Aldolase HRD68_RS21750 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase HRD68_RS21755 ENOG4106KNT transcriptional regulator HRD68_RS21760 ENOG4105CA9 Pyruvate kinase HRD68_RS21765 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase HRD68_RS21770 ENOG4105DR5 peptidase HRD68_RS21775 ENOG4105NXV High-affinity zinc uptake system protein HRD68_RS21780 ENOG4105FDK ABC transporter HRD68_RS21785 ENOG4105FAV ABC, transporter HRD68_RS21790 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) HRD68_RS21795 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) HRD68_RS21805 ENOG4105CDY transcriptional regulatory protein HRD68_RS21810 ENOG4108TIT dATP pyrophosphohydrolase HRD68_RS21815 ENOG4105C9M aspartyl-trna synthetase HRD68_RS21820 ENOG4105D3W isochorismatase HRD68_RS21825 ENOG41081XQ Conserved Protein HRD68_RS21830 ENOG4105WJG Glutathione HRD68_RS21840 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) HRD68_RS21845 ENOG4106N3A copper homeostasis protein cutc HRD68_RS21850 ENOG4106ZCM YecM protein HRD68_RS21860 ENOG4105CJR Integral membrane protein (MviN HRD68_RS21865 ENOG4105EP9 oxidoreductase HRD68_RS21875 ENOG4105D9U N-acetyltransferase HRD68_RS21880 ENOG4105EV4 Multidrug resistance protein mdtH HRD68_RS21885 ENOG4105F3T (LipO)protein HRD68_RS21890 ENOG4107XHZ cytoplasmic chaperone TorD family protein HRD68_RS21900 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase HRD68_RS21915 ENOG4105BZU Histidine kinase HRD68_RS21920 ENOG4105CHH sulfate transporter HRD68_RS21930 ENOG41063JG Transcriptional regulator HRD68_RS21935 ENOG4108YY7 Invasion gene expression up-regulator SirB HRD68_RS21940 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HRD68_RS21945 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) HRD68_RS21950 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) HRD68_RS21955 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) HRD68_RS21965 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HRD68_RS21970 ENOG4105MGX transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria HRD68_RS21975 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) HRD68_RS21985 ENOG4105C3G gtp-binding protein HRD68_RS21990 ENOG4105DFP Integrase HRD68_RS22035 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HRD68_RS22040 ENOG4108XS9 dna repair protein HRD68_RS22060 ENOG4105HVQ Regulatory factor of maltose metabolism HRD68_RS22100 ENOG4105DVF Cytosine-specific methyltransferase HRD68_RS22120 ENOG4105DTA methyltransferase HRD68_RS22125 ENOG4105D5K Hemolysin activator protein HRD68_RS22130 ENOG4105CKT filamentous hemagglutinin HRD68_RS22175 ENOG4105D6U Sodium Glutamate Symporter HRD68_RS22180 ENOG4107B2H carbonic anhydrase HRD68_RS22210 ENOG4107SET aldo keto reductase HRD68_RS22215 ENOG4105CEY Amp-dependent synthetase and ligase HRD68_RS22220 ENOG41090P5 ferredoxin-like protein HRD68_RS22225 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase HRD68_RS22230 ENOG4105C10 Electron transfer flavoprotein HRD68_RS22235 ENOG4105CV7 Electron transfer flavoprotein HRD68_RS22240 ENOG4105W4W Transcriptional regulator HRD68_RS22245 ENOG4105C1G acyl-Coa dehydrogenase HRD68_RS22250 ENOG4107R0K CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) HRD68_RS22265 ENOG4105EMV Major Facilitator HRD68_RS22270 ENOG4105DND Transcriptional regulator HRD68_RS22275 ENOG4105EMV Major Facilitator HRD68_RS22280 ENOG4105SUA Ydil protein HRD68_RS22285 ENOG4108K5P (LipO)protein HRD68_RS22295 ENOG4108MEK Metal-binding protein YodA HRD68_RS22300 ENOG4108HWV )-transporter HRD68_RS22305 ENOG4105C2J ABC transporter HRD68_RS22320 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) HRD68_RS22325 ENOG4105CZE histidine utilization repressor HRD68_RS22330 ENOG4105CI2 imidazolone-5-propionate hydrolase HRD68_RS22345 ENOG4107UI5 Transforms N(2)-succinylglutamate into succinate and glutamate (By similarity) HRD68_RS22350 ENOG4105EY2 Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity) HRD68_RS22360 ENOG4105F4X arginine HRD68_RS22365 ENOG4105C8Y Acetylornithine aminotransferase HRD68_RS22370 ENOG4108J20 pectate lyase HRD68_RS22375 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HRD68_RS22380 ENOG4105C4M (Ubiquinol oxidase) subunit I HRD68_RS22385 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HRD68_RS22395 ENOG4105BZU Histidine kinase HRD68_RS22400 ENOG4107R11 Transcriptional regulator HRD68_RS22410 ENOG4105EWV Sodium calcium exchanger membrane region HRD68_RS22415 ENOG4105D5M phosphate starvation-inducible protein HRD68_RS22430 ENOG4105CND Glycosyl transferase, family 2 HRD68_RS22435 ENOG4107BJW polysaccharide deacetylase HRD68_RS22440 ENOG4108TUY outer membrane protein PgaA HRD68_RS22445 ENOG4105H1N peptidase, M24 HRD68_RS22455 ENOG4105EXG Transcriptional regulator HRD68_RS22475 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HRD68_RS22485 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HRD68_RS22500 ENOG4107SJW iron permease, FTR1 HRD68_RS22510 ENOG4105VCP PTS System HRD68_RS22515 ENOG4105CS2 ec 3.2.1.21 HRD68_RS22520 ENOG4105CK1 PTS System HRD68_RS22525 ENOG4105VZJ PTS System HRD68_RS22530 ENOG4105DDV Transcriptional regulator (LacI family HRD68_RS22545 ENOG4105CSV Glutaminase HRD68_RS22550 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HRD68_RS22555 ENOG4108MRH transcriptional regulatory protein HRD68_RS22565 ENOG4105C85 amino acid HRD68_RS22570 ENOG4105K78 MarR family Transcriptional regulator HRD68_RS22580 ENOG4106UW1 Major Facilitator superfamily HRD68_RS22585 ENOG4108HCJ Hydrolase HRD68_RS22605 ENOG4108HMX isocitrate dehydrogenase (NADP) HRD68_RS22610 ENOG4108R99 pseudouridine synthase HRD68_RS22620 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) HRD68_RS22625 ENOG41075W9 High frequency lysogenization protein HflD homolog HRD68_RS22630 ENOG4107QTF adenylosuccinate lyase HRD68_RS22640 ENOG4105XJC Two component transcriptional regulator (Winged helix family HRD68_RS22645 ENOG4105IFJ Histidine kinase HRD68_RS22650 ENOG4105EZE Cupin 4 family protein HRD68_RS22665 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) HRD68_RS22670 ENOG4105D60 lipoprotein releasing system transmembrane protein HRD68_RS22680 ENOG4105D60 lipoprotein releasing system transmembrane protein HRD68_RS22685 ENOG4108JA2 transcriptioN-repair coupling factor HRD68_RS22690 ENOG4107MBR 17 kDa surface antigen HRD68_RS22695 ENOG4105CEP NADH dehydrogenase HRD68_RS22700 ENOG4105D0Y UPF0227 protein HRD68_RS22715 ENOG4108WEF Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity) HRD68_RS22720 ENOG41090DQ Lipoprotein HRD68_RS22725 ENOG4105K59 histidine triad (HIT) protein HRD68_RS22730 ENOG4105F9E Shikimate 5-dehydrogenase HRD68_RS22740 ENOG4105CI1 PTS System HRD68_RS22745 ENOG4105F8V Hydrolase, tatD family HRD68_RS22750 ENOG4107QRG dna polymerase iii HRD68_RS22755 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) HRD68_RS22760 ENOG4105HHA aminodeoxychorismate lyase HRD68_RS22765 ENOG4105YAZ 4-amino-4-deoxychorismate lyase HRD68_RS22770 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HRD68_RS22780 ENOG4105CHR reductase HRD68_RS22785 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HRD68_RS22795 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) HRD68_RS22800 ENOG4105VGS 50s ribosomal protein l32 HRD68_RS22805 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein HRD68_RS22815 ENOG4105EI2 Pseudouridine synthase HRD68_RS22820 ENOG4107QQB Ribonuclease E HRD68_RS22825 ENOG41067V3 Antibiotic biosynthesis monooxygenase HRD68_RS22830 ENOG4105EKE dihydroorotase HRD68_RS22840 ENOG4105PVA Biofilm formation regulatory protein BssS HRD68_RS22850 ENOG4105WH1 Two component transcriptional regulator luxr family HRD68_RS22860 ENOG4105DSF transport protein HRD68_RS22880 ENOG4105DB1 molybdopterin oxidoreductase HRD68_RS22885 ENOG4106WHD Tetrathionate reductase HRD68_RS22890 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HRD68_RS22895 ENOG4106AFQ Histidine kinase HRD68_RS22900 ENOG4108ZXC Two component transcriptional regulator, luxr family HRD68_RS22905 ENOG4105D1S lipid A biosynthesis HRD68_RS22910 ENOG4108VGI doxx family HRD68_RS22915 ENOG4105C6X Major Facilitator HRD68_RS22920 ENOG4105DUX Transporter HRD68_RS22930 ENOG4105NAC (LipO)protein HRD68_RS22935 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) HRD68_RS22940 ENOG4105DJ9 glucan biosynthesis protein HRD68_RS22955 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) HRD68_RS22965 ENOG4107YC3 synthase HRD68_RS22970 ENOG4105VJY transcriptional regulator HRD68_RS22975 ENOG4108DMF Cytochrome C biogenesis protein HRD68_RS22985 ENOG4107QX9 Thiol disulfide interChange protein HRD68_RS22990 ENOG4105DA4 cytochrome c-type biogenesis protein HRD68_RS22995 ENOG4105DVI reductase, NrfD HRD68_RS23000 ENOG4105D3S 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HRD68_RS23005 ENOG4105JJ8 Cytochrome c nitrite reductase, pentaheme subunit HRD68_RS23010 ENOG4105EAU Plays a role in nitrite reduction (By similarity) HRD68_RS23030 ENOG4105CE4 GlcNAc 6-P deacetylase HRD68_RS23035 ENOG4105C83 adenylosuccinate lyase HRD68_RS23040 ENOG4105CI1 PTS System HRD68_RS23050 ENOG4108YZG isomerase HRD68_RS23055 ENOG4105NYY transcriptional regulator, RpiR HRD68_RS23060 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HRD68_RS23065 ENOG4105C2J ABC transporter HRD68_RS23070 ENOG4105CNN ABC, transporter HRD68_RS23075 ENOG4105UP7 3-epimerase HRD68_RS23080 ENOG4107TFG D-allose kinase HRD68_RS23085 ENOG4105E98 transcriptional regulator DeoR family HRD68_RS23095 ENOG4105EDR glucose galactose transporter HRD68_RS23105 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) HRD68_RS23115 ENOG4105Y50 Virulence Protein HRD68_RS23130 ENOG4105UZW Tail fiber assembly protein