locus-tag	class	description
HRD68_RS00050	COG3121	Chaperone
HRD68_RS00055	COG3188	usher protein
HRD68_RS00075	COG1393	Belongs to the ArsC family
HRD68_RS00170	COG3504	Conjugal transfer protein
HRD68_RS00175	COG3736	Type IV secretory pathway, component VirB8
HRD68_RS00195	COG4115	mRNA cleavage
HRD68_RS00200	COG2161	toxin-antitoxin pair type II binding
HRD68_RS00245	COG1192	Involved in chromosome partitioning
HRD68_RS00265	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HRD68_RS00370	COG3311	Transcriptional regulator
HRD68_RS00375	COG1569	PIN domain
HRD68_RS00395	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HRD68_RS00400	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HRD68_RS00480	COG1609	Transcriptional regulator
HRD68_RS00490	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HRD68_RS00660	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HRD68_RS00805	COG3093	addiction module antidote protein HigA
HRD68_RS00810	COG3549	Plasmid maintenance system killer
HRD68_RS00955	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HRD68_RS00970	COG0741	lytic transglycosylase activity
HRD68_RS01120	COG4386	tail sheath protein
HRD68_RS01295	COG0582	viral genome integration into host DNA
HRD68_RS01305	COG2920	part of a sulfur-relay system
HRD68_RS01310	COG1254	Belongs to the acylphosphatase family
HRD68_RS01320	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HRD68_RS01325	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HRD68_RS01330	COG3785	DNA binding
HRD68_RS01335	COG1832	CoA-binding protein
HRD68_RS01345	COG1803	Methylglyoxal synthase
HRD68_RS01350	COG0210	DNA helicase
HRD68_RS01355	COG3304	Inner membrane component domain
HRD68_RS01360	COG1289	transmembrane transporter activity
HRD68_RS01365	COG3070	regulator of competence-specific genes
HRD68_RS01370	COG5404	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
HRD68_RS01380	COG3120	sequence-specific DNA binding
HRD68_RS01385	COG1067	ATP-dependent peptidase activity
HRD68_RS01390	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HRD68_RS01400	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HRD68_RS01405	COG3130	regulation of translation
HRD68_RS01410	COG3009	Protein conserved in bacteria
HRD68_RS01415	COG3008	intermembrane lipid transfer
HRD68_RS01415	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HRD68_RS01420	COG2995	paraquat-inducible protein a
HRD68_RS01425	COG0488	(ABC) transporter
HRD68_RS01430	COG0116	Belongs to the methyltransferase superfamily
HRD68_RS01430	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HRD68_RS01435	COG0633	Ferredoxin
HRD68_RS01435	COG3217	Mosc domain protein beta barrel domain protein
HRD68_RS01445	COG0167	dihydroorotate dehydrogenase activity
HRD68_RS01450	COG0308	aminopeptidase N
HRD68_RS01455	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HRD68_RS01460	COG0017	Asparaginyl-tRNA synthetase
HRD68_RS01470	COG1448	Aminotransferase
HRD68_RS01475	COG2200	EAL domain
HRD68_RS01480	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HRD68_RS01485	COG3108	Peptidase M15
HRD68_RS01490	COG2989	Protein conserved in bacteria
HRD68_RS01505	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
HRD68_RS01510	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HRD68_RS01515	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HRD68_RS01520	COG3173	Aminoglycoside phosphotransferase
HRD68_RS01530	COG2835	tetraacyldisaccharide 4'-kinase activity
HRD68_RS01535	COG1278	Cold shock
HRD68_RS01540	COG5383	Protein conserved in bacteria
HRD68_RS01560	COG0776	regulation of translation
HRD68_RS01565	COG0539	negative regulation of cytoplasmic translation
HRD68_RS01575	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HRD68_RS01585	COG2323	membrane
HRD68_RS01590	COG0252	asparaginase activity
HRD68_RS01595	COG1944	ATP diphosphatase activity
HRD68_RS01600	COG2116	formate transmembrane transporter activity
HRD68_RS01605	COG1882	Formate acetyltransferase
HRD68_RS01610	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HRD68_RS01615	COG2814	Major facilitator Superfamily
HRD68_RS01620	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HRD68_RS01625	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HRD68_RS01630	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HRD68_RS01635	COG1674	ftsk spoiiie
HRD68_RS01635	COG3107	peptidoglycan biosynthetic process
HRD68_RS01645	COG0492	ferredoxin-NADP+ reductase activity
HRD68_RS01650	COG4988	ABC transporter
HRD68_RS01655	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HRD68_RS01660	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HRD68_RS01665	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HRD68_RS01670	COG0542	response to heat
HRD68_RS01675	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HRD68_RS01680	COG1278	Cold shock
HRD68_RS01690	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HRD68_RS01695	COG2990	Protein conserved in bacteria
HRD68_RS01700	COG3593	DNA synthesis involved in DNA repair
HRD68_RS01705	COG2431	L-lysine efflux transmembrane transporter activity
HRD68_RS01710	COG1151	hydroxylamine reductase activity
HRD68_RS01715	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HRD68_RS01720	COG0028	Belongs to the TPP enzyme family
HRD68_RS01730	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HRD68_RS01735	COG0702	epimerase
HRD68_RS01740	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HRD68_RS01750	COG1605	Chorismate mutase
HRD68_RS01755	COG1126	abc transporter atp-binding protein
HRD68_RS01760	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HRD68_RS01765	COG4215	(ABC) transporter
HRD68_RS01770	COG4160	amino acid transport
HRD68_RS01775	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HRD68_RS01790	COG1177	transmembrane transport
HRD68_RS01795	COG1176	ABC-type spermidine putrescine transport system, permease component I
HRD68_RS01800	COG3842	ATPase activity
HRD68_RS01805	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HRD68_RS01825	COG2985	domain, Protein
HRD68_RS01825	COG0569	domain protein
HRD68_RS01840	COG5464	transposase or invertase
HRD68_RS01850	COG0671	phosphoesterase, PA-phosphatase related
HRD68_RS01855	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HRD68_RS01860	COG1349	DNA-binding transcription factor activity
HRD68_RS01865	COG0814	amino acid
HRD68_RS01870	COG1760	l-serine dehydratase
HRD68_RS01875	COG1686	Belongs to the peptidase S11 family
HRD68_RS01885	COG0626	cystathionine gamma-synthase activity
HRD68_RS01900	COG2011	ABC-type metal ion transport system permease component
HRD68_RS01925	COG0625	glutathione transferase activity
HRD68_RS01930	COG4771	TonB-dependent receptor
HRD68_RS01935	COG0833	amino acid
HRD68_RS01940	COG0583	DNA-binding transcription factor activity
HRD68_RS01950	COG2855	membrane
HRD68_RS01955	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HRD68_RS01960	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HRD68_RS01960	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HRD68_RS01960	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HRD68_RS01965	COG1105	Belongs to the carbohydrate kinase PfkB family
HRD68_RS01990	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HRD68_RS02000	COG0246	Mannitol dehydrogenase
HRD68_RS02005	COG2186	Transcriptional regulator
HRD68_RS02010	COG0523	cobalamin synthesis protein
HRD68_RS02015	COG0671	phosphoesterase, PA-phosphatase related
HRD68_RS02020	COG0791	NLP P60 protein
HRD68_RS02025	COG2200	EAL domain
HRD68_RS02030	COG4166	transmembrane transport
HRD68_RS02035	COG4174	ABC transporter (Permease)
HRD68_RS02040	COG4239	(ABC) transporter, permease
HRD68_RS02045	COG4172	Belongs to the ABC transporter superfamily
HRD68_RS02055	COG2814	Major facilitator Superfamily
HRD68_RS02060	COG1187	pseudouridine synthase activity
HRD68_RS02065	COG1061	Type III restriction enzyme res subunit
HRD68_RS02075	COG3081	Nucleoid-associated protein
HRD68_RS02080	COG3082	Protein of unknown function (DUF1414)
HRD68_RS02100	COG0657	acetylesterase activity
HRD68_RS02100	COG2755	lipolytic protein G-D-S-L family
HRD68_RS02105	COG3539	Fimbrial protein
HRD68_RS02110	COG3539	Fimbrial protein
HRD68_RS02115	COG3539	Fimbrial protein
HRD68_RS02125	COG3121	Chaperone
HRD68_RS02130	COG3539	Fimbrial protein
HRD68_RS02135	COG2723	6-phospho-beta-galactosidase activity
HRD68_RS02140	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HRD68_RS02140	COG2190	(PTS) system
HRD68_RS02140	COG1263	PTS System
HRD68_RS02145	COG1737	Transcriptional regulator
HRD68_RS02165	COG3121	Chaperone
HRD68_RS02200	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HRD68_RS02225	COG1132	(ABC) transporter
HRD68_RS02240	COG2223	nitrite transmembrane transporter activity
HRD68_RS02245	COG2198	Histidine kinase
HRD68_RS02245	COG0642	Histidine kinase
HRD68_RS02255	COG2205	protein histidine kinase activity
HRD68_RS02255	COG0784	Response regulator, receiver
HRD68_RS02270	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HRD68_RS02280	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HRD68_RS02285	COG4574	serine-type endopeptidase inhibitor activity
HRD68_RS02295	COG0814	amino acid
HRD68_RS02315	COG1441	menaquinone biosynthetic process
HRD68_RS02320	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HRD68_RS02330	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HRD68_RS02335	COG1169	isochorismate synthase
HRD68_RS02345	COG4575	ribosome binding
HRD68_RS02350	COG0129	dihydroxy-acid dehydratase activity
HRD68_RS02355	COG4702	Belongs to the UPF0303 family
HRD68_RS02365	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HRD68_RS02370	COG1609	Transcriptional regulator
HRD68_RS02375	COG1028	Short-chain dehydrogenase reductase Sdr
HRD68_RS02380	COG3265	gluconokinase activity
HRD68_RS02385	COG2731	YhcH YjgK YiaL family protein
HRD68_RS02405	COG1007	ATP synthesis coupled electron transport
HRD68_RS02410	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HRD68_RS02415	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HRD68_RS02420	COG0713	ATP synthesis coupled electron transport
HRD68_RS02425	COG0839	Belongs to the complex I subunit 6 family
HRD68_RS02430	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HRD68_RS02435	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HRD68_RS02440	COG1034	ATP synthesis coupled electron transport
HRD68_RS02455	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HRD68_RS02455	COG0649	NAD binding
HRD68_RS02460	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HRD68_RS02465	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HRD68_RS02470	COG0583	DNA-binding transcription factor activity
HRD68_RS02480	COG0436	Aminotransferase
HRD68_RS02485	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
HRD68_RS02490	COG0490	domain, Protein
HRD68_RS02490	COG0471	metal ion transport
HRD68_RS02500	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HRD68_RS02505	COG3013	Belongs to the UPF0304 family
HRD68_RS02510	COG3092	negative regulation of chromosome organization
HRD68_RS02520	COG0857	belongs to the CobB CobQ family
HRD68_RS02520	COG0280	phosphate acetyltransferase
HRD68_RS02525	COG1609	Transcriptional regulator
HRD68_RS02530	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HRD68_RS02540	COG3037	sugar-specific permease SgaT UlaA
HRD68_RS02550	COG4149	molybdate abc transporter
HRD68_RS02590	COG3778	Protein conserved in bacteria
HRD68_RS02595	COG3299	homolog of phage Mu protein gp47
HRD68_RS02640	COG4386	tail sheath protein
HRD68_RS02690	COG1802	Transcriptional regulator
HRD68_RS02690	COG4626	Terminase
HRD68_RS02735	COG0305	Participates in initiation and elongation during chromosome replication
HRD68_RS02740	COG1484	DNA-dependent DNA replication
HRD68_RS02760	COG1396	sequence-specific DNA binding
HRD68_RS02875	COG0582	viral genome integration into host DNA
HRD68_RS02880	COG0725	ABC transporter, periplasmic molybdate-binding protein
HRD68_RS02890	COG3585	molybdate ion transport
HRD68_RS02890	COG2005	Transcriptional regulator
HRD68_RS02895	COG1119	ATPase activity
HRD68_RS02905	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HRD68_RS02910	COG1085	galactose-1-phosphate uridylyltransferase
HRD68_RS02915	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HRD68_RS02920	COG2017	converts alpha-aldose to the beta-anomer
HRD68_RS02930	COG0588	phosphoglycerate mutase activity
HRD68_RS02935	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HRD68_RS02940	COG1230	cation diffusion facilitator family transporter
HRD68_RS02950	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HRD68_RS02980	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
HRD68_RS02985	COG2885	chlorophyll binding
HRD68_RS02990	COG0823	Involved in the tonB-independent uptake of proteins
HRD68_RS02995	COG3064	Membrane
HRD68_RS02995	COG3064	Membrane
HRD68_RS03000	COG0848	biopolymer transport protein
HRD68_RS03005	COG0811	peptide transport
HRD68_RS03010	COG0824	Thioesterase
HRD68_RS03015	COG3790	cyd operon protein YbgE
HRD68_RS03020	COG4890	Cyd operon protein YbgT
HRD68_RS03025	COG1294	oxidase, subunit
HRD68_RS03030	COG1271	oxidase subunit
HRD68_RS03035	COG0737	Belongs to the 5'-nucleotidase family
HRD68_RS03040	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HRD68_RS03050	COG0508	dehydrogenase complex catalyzes the overall conversion of
HRD68_RS03055	COG0567	Dehydrogenase, E1 component
HRD68_RS03060	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HRD68_RS03065	COG1053	succinate dehydrogenase
HRD68_RS03070	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HRD68_RS03100	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HRD68_RS03105	COG1984	allophanate hydrolase subunit 2
HRD68_RS03110	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HRD68_RS03115	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HRD68_RS03120	COG5212	phosphodiesterase
HRD68_RS03130	COG3272	Protein of unknown function (DUF1722)
HRD68_RS03145	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HRD68_RS03150	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HRD68_RS03155	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HRD68_RS03160	COG2205	protein histidine kinase activity
HRD68_RS03165	COG0745	RESPONSE REGULATOR receiver
HRD68_RS03175	COG0033	Phosphoglucomutase
HRD68_RS03180	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
HRD68_RS03185	COG0596	Alpha beta hydrolase
HRD68_RS03195	COG0840	transmembrane signaling receptor activity
HRD68_RS03205	COG0735	belongs to the Fur family
HRD68_RS03230	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HRD68_RS03235	COG2190	(PTS) system
HRD68_RS03235	COG1263	PTS System
HRD68_RS03235	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HRD68_RS03245	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HRD68_RS03250	COG1846	Transcriptional regulator
HRD68_RS03250	COG1940	carbohydrate kinase activity
HRD68_RS03255	COG0647	UMP catabolic process
HRD68_RS03260	COG0367	asparagine synthase
HRD68_RS03295	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HRD68_RS03300	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HRD68_RS03305	COG1702	phosphate starvation-inducible protein PhoH
HRD68_RS03310	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HRD68_RS03315	COG4535	Mg2 and Co2 transporter CorC
HRD68_RS03320	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HRD68_RS03330	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HRD68_RS03335	COG0765	amino acid transport
HRD68_RS03340	COG0765	amino acid transport
HRD68_RS03345	COG1126	abc transporter atp-binding protein
HRD68_RS03350	COG2888	peptidyl-tyrosine sulfation
HRD68_RS03360	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
HRD68_RS03365	COG1466	dna polymerase III delta subunit
HRD68_RS03370	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HRD68_RS03375	COG0799	negative regulation of ribosome biogenesis
HRD68_RS03385	COG0768	penicillin binding
HRD68_RS03390	COG0772	Belongs to the SEDS family
HRD68_RS03395	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HRD68_RS03400	COG1686	Belongs to the peptidase S11 family
HRD68_RS03405	COG2921	Belongs to the UPF0250 family
HRD68_RS03410	COG0321	lipoyl(octanoyl) transferase activity
HRD68_RS03415	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HRD68_RS03420	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HRD68_RS03425	COG3706	GGDEF domain
HRD68_RS03440	COG1278	Cold shock
HRD68_RS03445	COG2197	response regulator
HRD68_RS03455	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HRD68_RS03470	COG5265	(ABC) transporter
HRD68_RS03480	COG2850	peptidyl-arginine hydroxylation
HRD68_RS03485	COG2188	Transcriptional regulator
HRD68_RS03495	COG0471	metal ion transport
HRD68_RS03505	COG2979	Protein of unknown function (DUF533)
HRD68_RS03545	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HRD68_RS03550	COG2313	pseudouridylate synthase activity
HRD68_RS03555	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HRD68_RS03580	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HRD68_RS03600	COG3064	Membrane
HRD68_RS03620	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HRD68_RS03625	COG2501	S4 domain
HRD68_RS03645	COG3539	Fimbrial protein
HRD68_RS03655	COG3121	Chaperone
HRD68_RS03660	COG3188	usher protein
HRD68_RS03680	COG0215	cysteine-tRNA ligase activity
HRD68_RS03685	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HRD68_RS03690	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HRD68_RS03695	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HRD68_RS03700	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HRD68_RS03705	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HRD68_RS03710	COG4181	ATPase activity
HRD68_RS03715	COG2755	lipolytic protein G-D-S-L family
HRD68_RS03720	COG0300	oxidoreductase activity
HRD68_RS03725	COG3118	belongs to the thioredoxin family
HRD68_RS03730	COG0330	HflC and HflK could
HRD68_RS03735	COG1585	Membrane protein implicated in regulation of membrane protease activity
HRD68_RS03745	COG2217	Heavy metal translocating P-type atpase
HRD68_RS03750	COG3735	TraB family
HRD68_RS03755	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HRD68_RS03760	COG0737	Belongs to the 5'-nucleotidase family
HRD68_RS03765	COG2223	nitrite transmembrane transporter activity
HRD68_RS03770	COG4651	solute:proton antiporter activity
HRD68_RS03770	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HRD68_RS03775	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HRD68_RS03780	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
HRD68_RS03795	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HRD68_RS03820	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HRD68_RS03825	COG0563	adenylate kinase activity
HRD68_RS03830	COG0326	Molecular chaperone. Has ATPase activity
HRD68_RS03835	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HRD68_RS03850	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HRD68_RS03855	COG2832	Protein of unknown function (DUF454)
HRD68_RS03870	COG3264	Mechanosensitive ion channel
HRD68_RS03870	COG1196	nuclear chromosome segregation
HRD68_RS03875	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HRD68_RS03880	COG1309	transcriptional regulator
HRD68_RS03885	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HRD68_RS03890	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HRD68_RS03900	COG3457	Alanine racemase
HRD68_RS03905	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HRD68_RS03910	COG0254	rRNA binding
HRD68_RS03915	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HRD68_RS03920	COG0803	Belongs to the bacterial solute-binding protein 9 family
HRD68_RS03925	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HRD68_RS03930	COG1121	(ABC) transporter
HRD68_RS03965	COG3695	enzyme binding
HRD68_RS03970	COG3126	Type III secretion system lipoprotein chaperone (YscW)
HRD68_RS03975	COG1946	Acyl-CoA thioesterase
HRD68_RS03980	COG0004	ammonium transporteR
HRD68_RS03985	COG0347	Belongs to the P(II) protein family
HRD68_RS03990	COG1132	(ABC) transporter
HRD68_RS03995	COG1132	(ABC) transporter
HRD68_RS04000	COG1522	sequence-specific DNA binding
HRD68_RS04010	COG0561	phosphatase activity
HRD68_RS04015	COG4533	DNA binding
HRD68_RS04020	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HRD68_RS04025	COG0824	Thioesterase
HRD68_RS04030	COG1555	photosystem II stabilization
HRD68_RS04035	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HRD68_RS04040	COG0776	regulation of translation
HRD68_RS04045	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HRD68_RS04050	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HRD68_RS04055	COG0740	serine-type endopeptidase activity
HRD68_RS04060	COG0544	peptidyl-prolyl cis-trans isomerase activity
HRD68_RS04065	COG0271	Belongs to the BolA IbaG family
HRD68_RS04070	COG3056	Lipoprotein
HRD68_RS04075	COG2223	nitrite transmembrane transporter activity
HRD68_RS04085	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HRD68_RS04090	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HRD68_RS04095	COG1845	cytochrome c oxidase, subunit III
HRD68_RS04100	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HRD68_RS04105	COG0109	protoheme IX farnesyltransferase activity
HRD68_RS04110	COG2814	Major facilitator Superfamily
HRD68_RS04115	COG1666	GTP binding
HRD68_RS04120	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HRD68_RS04125	COG0693	protein deglycase activity
HRD68_RS04130	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HRD68_RS04130	COG0301	tRNA thio-modification
HRD68_RS04140	COG0142	geranyltranstransferase activity
HRD68_RS04145	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HRD68_RS04150	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HRD68_RS04155	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HRD68_RS04170	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HRD68_RS04170	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HRD68_RS04175	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HRD68_RS04185	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HRD68_RS04190	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HRD68_RS04195	COG1862	Preprotein translocase
HRD68_RS04200	COG0343	queuine tRNA-ribosyltransferase activity
HRD68_RS04210	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
HRD68_RS04215	COG0450	alkyl hydroperoxide reductase
HRD68_RS04230	COG0366	Alpha amylase catalytic
HRD68_RS04250	COG5002	protein histidine kinase activity
HRD68_RS04255	COG0745	RESPONSE REGULATOR receiver
HRD68_RS04260	COG0420	3'-5' exonuclease activity
HRD68_RS04265	COG0419	ATPase involved in DNA repair
HRD68_RS04270	COG1940	carbohydrate kinase activity
HRD68_RS04275	COG2974	May be involved in recombination
HRD68_RS04280	COG3123	guanosine phosphorylase activity
HRD68_RS04285	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HRD68_RS04300	COG2226	methyltransferase
HRD68_RS04315	COG3459	Glycosyltransferase 36 associated
HRD68_RS04325	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HRD68_RS04330	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HRD68_RS04350	COG2195	Cleaves the N-terminal amino acid of tripeptides
HRD68_RS04355	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HRD68_RS04365	COG2991	Protein conserved in bacteria
HRD68_RS04370	COG1477	protein flavinylation
HRD68_RS04375	COG2871	sodium ion transport
HRD68_RS04380	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HRD68_RS04385	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HRD68_RS04390	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HRD68_RS04395	COG1805	sodium ion transport
HRD68_RS04400	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HRD68_RS04405	COG3034	peptidoglycan biosynthetic process
HRD68_RS04410	COG0121	glutamine amidotransferase
HRD68_RS04420	COG1960	acyl-CoA dehydrogenase activity
HRD68_RS04425	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
HRD68_RS04440	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
HRD68_RS04450	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
HRD68_RS04460	COG0235	Class ii aldolase
HRD68_RS04465	COG0436	Aminotransferase
HRD68_RS04475	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HRD68_RS04480	COG2814	Major facilitator Superfamily
HRD68_RS04485	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HRD68_RS04495	COG1846	Transcriptional regulator
HRD68_RS04505	COG1566	PFAM secretion protein HlyD family protein
HRD68_RS04510	COG2814	Major facilitator Superfamily
HRD68_RS04515	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HRD68_RS04520	COG3118	belongs to the thioredoxin family
HRD68_RS04530	COG1042	CoA-binding domain protein
HRD68_RS04530	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HRD68_RS04530	COG0045	succinate-CoA ligase (ADP-forming) activity
HRD68_RS04535	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HRD68_RS04565	COG0542	response to heat
HRD68_RS04575	COG0564	pseudouridine synthase activity
HRD68_RS04580	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HRD68_RS04585	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HRD68_RS04590	COG0077	Prephenate dehydratase
HRD68_RS04590	COG1605	Chorismate mutase
HRD68_RS04595	COG1605	Chorismate mutase
HRD68_RS04595	COG0287	Prephenate dehydrogenase
HRD68_RS04600	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HRD68_RS04605	COG3279	Response regulator of the LytR AlgR family
HRD68_RS04610	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HRD68_RS04615	COG3137	Salt-induced outer membrane protein
HRD68_RS04620	COG0335	large ribosomal subunit rRNA binding
HRD68_RS04630	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HRD68_RS04640	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HRD68_RS04645	COG4137	Cytochrome C assembly protein
HRD68_RS04650	COG4536	flavin adenine dinucleotide binding
HRD68_RS04655	COG1854	S-ribosylhomocysteine lyase activity
HRD68_RS04660	COG2918	glutathione biosynthetic process
HRD68_RS04665	COG1238	metal cluster binding
HRD68_RS04670	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HRD68_RS04695	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HRD68_RS04700	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HRD68_RS04705	COG2137	regulation of response to DNA damage stimulus
HRD68_RS04710	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HRD68_RS04735	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HRD68_RS04740	COG3958	Transketolase
HRD68_RS04745	COG3959	Transketolase, thiamine diphosphate binding domain
HRD68_RS04750	COG1172	Belongs to the binding-protein-dependent transport system permease family
HRD68_RS04755	COG1129	ABC transporter
HRD68_RS04780	COG3381	protein complex oligomerization
HRD68_RS04785	COG3302	dmso reductase anchor subunit
HRD68_RS04790	COG0437	4 iron, 4 sulfur cluster binding
HRD68_RS04795	COG0243	molybdopterin cofactor binding
HRD68_RS04800	COG1454	alcohol dehydrogenase
HRD68_RS04805	COG0235	Class ii aldolase
HRD68_RS04810	COG0738	Major facilitator superfamily
HRD68_RS04820	COG1070	Carbohydrate kinase
HRD68_RS04830	COG1349	DNA-binding transcription factor activity
HRD68_RS04840	COG1349	DNA-binding transcription factor activity
HRD68_RS04850	COG1129	ABC transporter
HRD68_RS04855	COG1172	Belongs to the binding-protein-dependent transport system permease family
HRD68_RS04865	COG3623	hexulose-6-phosphate isomerase
HRD68_RS04870	COG1070	Carbohydrate kinase
HRD68_RS04875	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HRD68_RS04875	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HRD68_RS04890	COG4177	L-phenylalanine transmembrane transporter activity
HRD68_RS04895	COG1137	ATPase activity
HRD68_RS04900	COG0410	ABC transporter
HRD68_RS04955	COG0640	Transcriptional regulator
HRD68_RS04960	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HRD68_RS04975	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HRD68_RS04980	COG1126	abc transporter atp-binding protein
HRD68_RS04985	COG0765	amino acid transport
HRD68_RS04990	COG0765	amino acid transport
HRD68_RS05000	COG3048	D-serine ammonia-lyase activity
HRD68_RS05005	COG2610	gluconate transmembrane transporter activity
HRD68_RS05010	COG0583	DNA-binding transcription factor activity
HRD68_RS05015	COG4608	Belongs to the ABC transporter superfamily
HRD68_RS05020	COG0444	Belongs to the ABC transporter superfamily
HRD68_RS05030	COG0601	transmembrane transport
HRD68_RS05035	COG0747	negative chemotaxis
HRD68_RS05040	COG4948	Mandelate Racemase Muconate Lactonizing
HRD68_RS05045	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HRD68_RS05060	COG1028	Short-chain dehydrogenase reductase Sdr
HRD68_RS05080	COG1538	Outer membrane efflux protein
HRD68_RS05085	COG0577	efflux transmembrane transporter activity
HRD68_RS05085	COG1136	(ABC) transporter
HRD68_RS05090	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HRD68_RS05120	COG3539	Fimbrial protein
HRD68_RS05125	COG3539	Fimbrial protein
HRD68_RS05140	COG3121	Chaperone
HRD68_RS05145	COG3188	usher protein
HRD68_RS05170	COG3876	Protein conserved in bacteria
HRD68_RS05180	COG1472	Belongs to the glycosyl hydrolase 3 family
HRD68_RS05190	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HRD68_RS05195	COG1263	PTS System
HRD68_RS05195	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HRD68_RS05210	COG3121	Chaperone
HRD68_RS05215	COG3121	Chaperone
HRD68_RS05225	COG3121	Chaperone
HRD68_RS05240	COG0626	cystathionine gamma-synthase activity
HRD68_RS05250	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HRD68_RS05255	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HRD68_RS05260	COG1388	LysM domain
HRD68_RS05260	COG4942	peptidase
HRD68_RS05265	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HRD68_RS05270	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HRD68_RS05275	COG0585	pseudouridine synthase activity
HRD68_RS05280	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HRD68_RS05290	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HRD68_RS05300	COG0765	amino acid transport
HRD68_RS05315	COG0529	Catalyzes the synthesis of activated sulfate
HRD68_RS05320	COG2895	sulfate adenylyltransferase (ATP) activity
HRD68_RS05325	COG0175	sulfate reduction
HRD68_RS05330	COG1648	precorrin-2 dehydrogenase activity
HRD68_RS05330	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HRD68_RS05335	COG2234	aminopeptidase activity
HRD68_RS05340	COG0175	sulfate reduction
HRD68_RS05345	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HRD68_RS05350	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HRD68_RS05355	COG0720	synthase
HRD68_RS05360	COG0602	queuosine metabolic process
HRD68_RS05375	COG0504	CTP synthase activity
HRD68_RS05380	COG3956	TIGRFAM MazG family protein
HRD68_RS05385	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HRD68_RS05390	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HRD68_RS05400	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HRD68_RS05405	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HRD68_RS05410	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HRD68_RS05420	COG2860	membrane
HRD68_RS05430	COG0316	Belongs to the HesB IscA family
HRD68_RS05440	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HRD68_RS05445	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HRD68_RS05450	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HRD68_RS05455	COG1120	ATPase activity
HRD68_RS05460	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HRD68_RS05465	COG1643	Atp-dependent helicase
HRD68_RS05470	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HRD68_RS05490	COG0617	tRNA 3'-terminal CCA addition
HRD68_RS05495	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HRD68_RS05500	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HRD68_RS05505	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HRD68_RS05510	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HRD68_RS05515	COG0726	polysaccharide deacetylase
HRD68_RS05520	COG0842	Transport permease protein
HRD68_RS05525	COG1131	(ABC) transporter
HRD68_RS05530	COG0288	reversible hydration of carbon dioxide
HRD68_RS05535	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HRD68_RS05545	COG2132	Multicopper oxidase
HRD68_RS05555	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HRD68_RS05570	COG3112	Uncharacterised protein family (UPF0231)
HRD68_RS05590	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HRD68_RS05595	COG0508	dehydrogenase complex catalyzes the overall conversion of
HRD68_RS05600	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HRD68_RS05605	COG2186	Transcriptional regulator
HRD68_RS05610	COG1113	amino acid transport
HRD68_RS05620	COG3725	Membrane protein required for beta-lactamase induction
HRD68_RS05625	COG3023	N-Acetylmuramoyl-L-alanine amidase
HRD68_RS05635	COG4969	Belongs to the N-Me-Phe pilin family
HRD68_RS05640	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HRD68_RS05645	COG1459	type II secretion system
HRD68_RS05650	COG0516	GMP reductase activity
HRD68_RS05665	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
HRD68_RS05670	COG0494	nUDIX hydrolase
HRD68_RS05675	COG0653	protein targeting
HRD68_RS05695	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HRD68_RS05700	COG0849	cell division
HRD68_RS05705	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HRD68_RS05715	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HRD68_RS05720	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HRD68_RS05725	COG0772	Belongs to the SEDS family
HRD68_RS05735	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HRD68_RS05740	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HRD68_RS05745	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HRD68_RS05750	COG0768	penicillin binding
HRD68_RS05755	COG3116	cell division
HRD68_RS05760	COG0275	rRNA processing
HRD68_RS05785	COG0028	Belongs to the TPP enzyme family
HRD68_RS05790	COG1022	Amp-dependent synthetase and ligase
HRD68_RS05810	COG0473	3-isopropylmalate dehydrogenase activity
HRD68_RS05815	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HRD68_RS05830	COG3033	Beta-eliminating lyase
HRD68_RS05835	COG0814	amino acid
HRD68_RS05840	COG2814	Major facilitator Superfamily
HRD68_RS05845	COG1882	Formate acetyltransferase
HRD68_RS05850	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HRD68_RS05855	COG4533	DNA binding
HRD68_RS05860	COG4143	(ABC) transporter
HRD68_RS05865	COG1178	ABC-type Fe3 transport system permease component
HRD68_RS05870	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
HRD68_RS05875	COG0586	Pfam SNARE associated Golgi protein
HRD68_RS05880	COG0417	DNA replication proofreading
HRD68_RS05890	COG2375	cellular response to nickel ion
HRD68_RS05925	COG0564	pseudouridine synthase activity
HRD68_RS05935	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HRD68_RS05940	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HRD68_RS05955	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HRD68_RS05960	COG2967	ApaG domain
HRD68_RS05965	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HRD68_RS05970	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HRD68_RS05980	COG2966	Psort location CytoplasmicMembrane, score
HRD68_RS05985	COG1280	lysine exporter protein (LysE YggA)
HRD68_RS05990	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HRD68_RS06005	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HRD68_RS06010	COG1047	Peptidyl-prolyl cis-trans
HRD68_RS06020	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HRD68_RS06025	COG0196	riboflavin kinase activity
HRD68_RS06045	COG0583	DNA-binding transcription factor activity
HRD68_RS06050	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HRD68_RS06060	COG0484	heat shock protein binding
HRD68_RS06070	COG1584	GPR1 FUN34 yaaH family protein
HRD68_RS06085	COG0521	Mo-molybdopterin cofactor biosynthetic process
HRD68_RS06090	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HRD68_RS06095	COG3022	response to hydroperoxide
HRD68_RS06105	COG0083	homoserine kinase activity
HRD68_RS06120	COG0745	RESPONSE REGULATOR receiver
HRD68_RS06125	COG3045	CreA protein
HRD68_RS06130	COG2207	Transcriptional regulator
HRD68_RS06130	COG3708	Transcriptional regulator
HRD68_RS06135	COG0406	alpha-ribazole phosphatase activity
HRD68_RS06140	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
HRD68_RS06145	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
HRD68_RS06150	COG0741	lytic transglycosylase activity
HRD68_RS06155	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HRD68_RS06165	COG2199	diguanylate cyclase activity
HRD68_RS06170	COG2885	chlorophyll binding
HRD68_RS06175	COG0488	(ABC) transporter
HRD68_RS06210	COG1454	alcohol dehydrogenase
HRD68_RS06225	COG0604	alcohol dehydrogenase
HRD68_RS06240	COG0560	Phosphoserine phosphatase
HRD68_RS06245	COG3726	membrane protein affecting hemolysin expression
HRD68_RS06250	COG2026	Addiction module toxin, RelE StbE family
HRD68_RS06265	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HRD68_RS06280	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HRD68_RS06285	COG0084	hydrolase, TatD family'
HRD68_RS06290	COG4667	esterase of the alpha-beta hydrolase superfamily
HRD68_RS06300	COG2823	Periplasmic or secreted lipoprotein
HRD68_RS06305	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HRD68_RS06315	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
HRD68_RS06320	COG2813	Specifically methylates the guanine in position
HRD68_RS06325	COG0667	Aldo Keto reductase
HRD68_RS06355	COG3706	GGDEF domain
HRD68_RS06360	COG3284	Transcriptional regulator
HRD68_RS06370	COG0738	Major facilitator superfamily
HRD68_RS06385	COG2192	nodulation
HRD68_RS06395	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HRD68_RS06395	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HRD68_RS06395	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
HRD68_RS06400	COG1461	Dihydroxyacetone kinase
HRD68_RS06405	COG2376	Dihydroxyacetone kinase
HRD68_RS06415	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HRD68_RS06420	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HRD68_RS06425	COG2235	arginine
HRD68_RS06440	COG0859	PFAM glycosyl transferase family 9
HRD68_RS06445	COG1070	Carbohydrate kinase
HRD68_RS06450	COG2390	Transcriptional regulator
HRD68_RS06455	COG1129	ABC transporter
HRD68_RS06460	COG1172	Belongs to the binding-protein-dependent transport system permease family
HRD68_RS06465	COG1172	Belongs to the binding-protein-dependent transport system permease family
HRD68_RS06475	COG1830	Aldolase
HRD68_RS06490	COG3550	peptidyl-serine autophosphorylation
HRD68_RS06495	COG1396	sequence-specific DNA binding
HRD68_RS06510	COG2771	luxR family
HRD68_RS06585	COG1401	restriction endodeoxyribonuclease activity
HRD68_RS06630	COG0582	viral genome integration into host DNA
HRD68_RS06640	COG0795	lipopolysaccharide-transporting ATPase activity
HRD68_RS06645	COG0795	lipopolysaccharide-transporting ATPase activity
HRD68_RS06650	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HRD68_RS06655	COG2927	DNA polymerase III (CHI subunit)
HRD68_RS06670	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
HRD68_RS06680	COG2731	YhcH YjgK YiaL family protein
HRD68_RS06690	COG0601	transmembrane transport
HRD68_RS06700	COG0444	Belongs to the ABC transporter superfamily
HRD68_RS06705	COG4608	Belongs to the ABC transporter superfamily
HRD68_RS06725	COG0602	queuosine metabolic process
HRD68_RS06740	COG2188	Transcriptional regulator
HRD68_RS06745	COG3624	Phosphonate C-P lyase system protein PhnG
HRD68_RS06750	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
HRD68_RS06755	COG3626	phosphonate metabolism
HRD68_RS06760	COG3627	carbon phosphorus lyase activity
HRD68_RS06765	COG4107	phosphonate C-P lyase system protein PhnK
HRD68_RS06770	COG4778	phosphonate C-P lyase system protein PhnL
HRD68_RS06775	COG3454	Phosphonate metabolism
HRD68_RS06780	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
HRD68_RS06785	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HRD68_RS06790	COG0702	epimerase
HRD68_RS06805	COG3842	ATPase activity
HRD68_RS06810	COG0395	ABC-type sugar transport system, permease component
HRD68_RS06815	COG1175	transmembrane transport
HRD68_RS06820	COG1653	transport
HRD68_RS06840	COG1982	Orn Lys Arg decarboxylase major
HRD68_RS06845	COG0531	amino acid
HRD68_RS06855	COG3153	acetyltransferase
HRD68_RS06860	COG3154	lipid carrier protein
HRD68_RS06865	COG0826	peptidase U32
HRD68_RS06870	COG0826	peptidase U32
HRD68_RS06875	COG3681	Belongs to the UPF0597 family
HRD68_RS06880	COG0814	amino acid
HRD68_RS06885	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HRD68_RS06890	COG0513	Belongs to the DEAD box helicase family
HRD68_RS06905	COG1185	polyribonucleotide nucleotidyltransferase activity
HRD68_RS06915	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HRD68_RS06920	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HRD68_RS06930	COG0195	Participates in both transcription termination and antitermination
HRD68_RS06950	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HRD68_RS06960	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HRD68_RS06970	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HRD68_RS06975	COG1534	Rna-binding protein
HRD68_RS06985	COG2027	D-alanyl-D-alanine carboxypeptidase
HRD68_RS06990	COG0745	RESPONSE REGULATOR receiver
HRD68_RS06995	COG0642	Histidine kinase
HRD68_RS07000	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HRD68_RS07005	COG0697	spore germination
HRD68_RS07010	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HRD68_RS07020	COG0142	geranyltranstransferase activity
HRD68_RS07030	COG3423	Transcriptional regulator
HRD68_RS07050	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HRD68_RS07065	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HRD68_RS07070	COG2105	PFAM AIG2 family protein
HRD68_RS07075	COG2911	Protein conserved in bacteria
HRD68_RS07085	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HRD68_RS07090	COG1253	flavin adenine dinucleotide binding
HRD68_RS07100	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HRD68_RS07105	COG1218	3'(2'),5'-bisphosphate nucleotidase
HRD68_RS07110	COG0737	Belongs to the 5'-nucleotidase family
HRD68_RS07120	COG0545	Peptidyl-prolyl cis-trans isomerase
HRD68_RS07125	COG3061	Opacity-associated protein A
HRD68_RS07135	COG0359	binds to the 23S rRNA
HRD68_RS07140	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HRD68_RS07150	COG0360	Binds together with S18 to 16S ribosomal RNA
HRD68_RS07160	COG1073	alpha beta
HRD68_RS07165	COG3650	response to hydrogen peroxide
HRD68_RS07170	COG1960	acyl-CoA dehydrogenase activity
HRD68_RS07175	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HRD68_RS07180	COG0557	exoribonuclease II activity
HRD68_RS07185	COG1959	2 iron, 2 sulfur cluster binding
HRD68_RS07195	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
HRD68_RS07200	COG0330	HflC and HflK could
HRD68_RS07205	COG0330	HflC and HflK could
HRD68_RS07210	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HRD68_RS07220	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HRD68_RS07235	COG0802	atpase or kinase
HRD68_RS07240	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HRD68_RS07240	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HRD68_RS07245	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HRD68_RS07265	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HRD68_RS07270	COG1162	GTPase activity
HRD68_RS07275	COG0688	phosphatidylethanolamine metabolic process
HRD68_RS07280	COG3264	Mechanosensitive ion channel
HRD68_RS07280	COG1511	domain protein
HRD68_RS07290	COG1053	succinate dehydrogenase
HRD68_RS07295	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HRD68_RS07300	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
HRD68_RS07305	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
HRD68_RS07325	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HRD68_RS07340	COG0459	protein refolding
HRD68_RS07345	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HRD68_RS07360	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HRD68_RS07370	COG4232	protein-disulfide reductase activity
HRD68_RS07375	COG3383	formate dehydrogenase (NAD+) activity
HRD68_RS07380	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HRD68_RS07380	COG0493	'glutamate synthase
HRD68_RS07385	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HRD68_RS07385	COG0493	'glutamate synthase
HRD68_RS07390	COG2271	Major facilitator Superfamily
HRD68_RS07395	COG1929	Belongs to the glycerate kinase type-1 family
HRD68_RS07400	COG2721	sulfolactate sulfo-lyase activity
HRD68_RS07405	COG3835	regulator
HRD68_RS07410	COG1929	Belongs to the glycerate kinase type-1 family
HRD68_RS07415	COG2084	Dehydrogenase
HRD68_RS07425	COG1309	transcriptional regulator
HRD68_RS07435	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HRD68_RS07435	COG0543	2 iron, 2 sulfur cluster binding
HRD68_RS07440	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HRD68_RS07470	COG0463	Glycosyl transferase, family 2
HRD68_RS07485	COG0489	protein tyrosine kinase activity
HRD68_RS07495	COG1215	transferase activity, transferring glycosyl groups
HRD68_RS07500	COG0457	Tetratricopeptide repeat
HRD68_RS07510	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
HRD68_RS07520	COG3721	Heme iron utilization protein
HRD68_RS07525	COG0702	epimerase
HRD68_RS07535	COG4771	TonB-dependent receptor
HRD68_RS07540	COG3720	iron ion transport
HRD68_RS07545	COG4558	Periplasmic binding protein
HRD68_RS07550	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HRD68_RS07555	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HRD68_RS07560	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HRD68_RS07570	COG4774	siderophore transport
HRD68_RS07575	COG1196	nuclear chromosome segregation
HRD68_RS07575	COG3264	Mechanosensitive ion channel
HRD68_RS07725	COG2197	response regulator
HRD68_RS07730	COG2205	protein histidine kinase activity
HRD68_RS07770	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HRD68_RS07815	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HRD68_RS07825	COG3397	chitin binding
HRD68_RS07835	COG0612	Peptidase, M16
HRD68_RS07840	COG4178	(ABC) transporter
HRD68_RS07845	COG4771	TonB-dependent receptor
HRD68_RS07850	COG3712	iron ion homeostasis
HRD68_RS07855	COG1595	DNA-templated transcription, initiation
HRD68_RS07870	COG3093	addiction module antidote protein HigA
HRD68_RS07875	COG0425	Belongs to the sulfur carrier protein TusA family
HRD68_RS07880	COG2391	methyltransferase activity
HRD68_RS08045	COG1301	dicarboxylic acid transport
HRD68_RS08050	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HRD68_RS08055	COG3162	membrane
HRD68_RS08060	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HRD68_RS08105	COG0151	Belongs to the GarS family
HRD68_RS08125	COG1515	deoxyribonuclease V activity
HRD68_RS08135	COG2816	NAD+ diphosphatase activity
HRD68_RS08140	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
HRD68_RS08155	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HRD68_RS08160	COG2104	thiamine diphosphate biosynthetic process
HRD68_RS08175	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HRD68_RS08180	COG0085	RNA polymerase activity
HRD68_RS08185	COG0222	ribosome binding
HRD68_RS08190	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HRD68_RS08200	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HRD68_RS08205	COG0250	Participates in transcription elongation, termination and antitermination
HRD68_RS08245	COG1072	(Pantothenic acid kinase))
HRD68_RS08250	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HRD68_RS08250	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HRD68_RS08285	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HRD68_RS08290	COG1739	Uncharacterized protein family UPF0029
HRD68_RS08300	COG1250	3-hydroxyacyl-CoA dehydrogenase
HRD68_RS08300	COG1024	Enoyl-CoA hydratase
HRD68_RS08305	COG0183	Belongs to the thiolase family
HRD68_RS08315	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HRD68_RS08335	COG0805	protein transport
HRD68_RS08345	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HRD68_RS08350	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HRD68_RS08360	COG2226	methyltransferase
HRD68_RS08365	COG1322	Protein conserved in bacteria
HRD68_RS08370	COG0586	Pfam SNARE associated Golgi protein
HRD68_RS08375	COG1966	Carbon starvation protein
HRD68_RS08390	COG0412	Dienelactone hydrolase
HRD68_RS08395	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HRD68_RS08400	COG0583	DNA-binding transcription factor activity
HRD68_RS08405	COG0697	spore germination
HRD68_RS08410	COG0679	Auxin Efflux Carrier
HRD68_RS08415	COG0584	glycerophosphoryl diester phosphodiesterase
HRD68_RS08420	COG3842	ATPase activity
HRD68_RS08425	COG0395	ABC-type sugar transport system, permease component
HRD68_RS08430	COG1175	transmembrane transport
HRD68_RS08435	COG1653	transport
HRD68_RS08470	COG0410	ABC transporter
HRD68_RS08480	COG4177	L-phenylalanine transmembrane transporter activity
HRD68_RS08490	COG0683	leucine binding
HRD68_RS08495	COG0456	acetyltransferase
HRD68_RS08505	COG2177	Part of the ABC transporter FtsEX involved in
HRD68_RS08510	COG2884	Cell division ATP-binding protein ftsE
HRD68_RS08515	COG0552	protein localization to endoplasmic reticulum
HRD68_RS08515	COG0552	protein localization to endoplasmic reticulum
HRD68_RS08520	COG0742	ribosomal rna small subunit methyltransferase
HRD68_RS08525	COG3776	membrane
HRD68_RS08540	COG3714	YhhN family
HRD68_RS08550	COG0425	Belongs to the sulfur carrier protein TusA family
HRD68_RS08555	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HRD68_RS08565	COG0247	lactate metabolic process
HRD68_RS08575	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HRD68_RS08580	COG2271	Major facilitator Superfamily
HRD68_RS08585	COG0584	glycerophosphoryl diester phosphodiesterase
HRD68_RS08590	COG0561	phosphatase activity
HRD68_RS08595	COG2267	carboxylic ester hydrolase activity
HRD68_RS08600	COG1280	lysine exporter protein (LysE YggA)
HRD68_RS08605	COG1280	lysine exporter protein (LysE YggA)
HRD68_RS08610	COG0514	ATP-dependent DNA helicase (RecQ)
HRD68_RS08615	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
HRD68_RS08620	COG2050	protein possibly involved in aromatic compounds catabolism
HRD68_RS08635	COG5564	TIM-barrel signal transduction protein
HRD68_RS08650	COG0210	DNA helicase
HRD68_RS08655	COG1011	Hydrolase
HRD68_RS08660	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HRD68_RS08665	COG3159	Protein conserved in bacteria
HRD68_RS08670	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HRD68_RS08675	COG5567	small periplasmic lipoprotein
HRD68_RS08685	COG3072	Adenylate cyclase
HRD68_RS08690	COG0181	hydroxymethylbilane synthase activity
HRD68_RS08695	COG1587	Uroporphyrinogen-III synthase
HRD68_RS08700	COG2959	enzyme of heme biosynthesis
HRD68_RS08705	COG3071	HemY protein
HRD68_RS08730	COG1113	amino acid transport
HRD68_RS08745	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HRD68_RS08750	COG2244	polysaccharide biosynthetic process
HRD68_RS08755	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HRD68_RS08760	COG0456	acetyltransferase
HRD68_RS08765	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HRD68_RS08770	COG1088	dTDP-glucose 4,6-dehydratase activity
HRD68_RS08775	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HRD68_RS08780	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HRD68_RS08785	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
HRD68_RS08790	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HRD68_RS08795	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HRD68_RS08800	COG3118	belongs to the thioredoxin family
HRD68_RS08810	COG0248	Ppx GppA phosphatase
HRD68_RS08825	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HRD68_RS08835	COG3121	Chaperone
HRD68_RS08850	COG3121	Chaperone
HRD68_RS08855	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HRD68_RS08860	COG0583	DNA-binding transcription factor activity
HRD68_RS08870	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HRD68_RS08875	COG0129	dihydroxy-acid dehydratase activity
HRD68_RS08880	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HRD68_RS08885	COG3978	acetolactate synthase activity
HRD68_RS08905	COG3085	chromosome segregation
HRD68_RS08910	COG0583	DNA-binding transcription factor activity
HRD68_RS08915	COG1172	Belongs to the binding-protein-dependent transport system permease family
HRD68_RS08920	COG1172	Belongs to the binding-protein-dependent transport system permease family
HRD68_RS08925	COG1129	ABC transporter
HRD68_RS08930	COG1879	ABC-type sugar transport system periplasmic component
HRD68_RS08970	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HRD68_RS08980	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HRD68_RS08995	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HRD68_RS09005	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HRD68_RS09005	COG0678	peroxiredoxin activity
HRD68_RS09010	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HRD68_RS09035	COG1629	transport
HRD68_RS09040	COG0165	Argininosuccinate lyase
HRD68_RS09060	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HRD68_RS09070	COG2814	Major facilitator Superfamily
HRD68_RS09075	COG1494	fructose-1,6-bisphosphatase
HRD68_RS09080	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HRD68_RS09085	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HRD68_RS09090	COG3074	FtsZ-dependent cytokinesis
HRD68_RS09095	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HRD68_RS09100	COG1575	Belongs to the MenA family. Type 1 subfamily
HRD68_RS09105	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HRD68_RS09110	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HRD68_RS09115	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HRD68_RS09120	COG1609	Transcriptional regulator
HRD68_RS09125	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HRD68_RS09130	COG0254	rRNA binding
HRD68_RS09135	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
HRD68_RS09140	COG0626	cystathionine gamma-synthase activity
HRD68_RS09145	COG0527	aspartate kinase activity
HRD68_RS09145	COG0460	homoserine dehydrogenase
HRD68_RS09155	COG3152	Membrane
HRD68_RS09175	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HRD68_RS09185	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HRD68_RS09190	COG3678	ATP-independent chaperone mediated protein folding
HRD68_RS09195	COG0745	RESPONSE REGULATOR receiver
HRD68_RS09200	COG2205	protein histidine kinase activity
HRD68_RS09205	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HRD68_RS09205	COG2169	Transcriptional regulator
HRD68_RS09210	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HRD68_RS09215	COG1045	serine acetyltransferase
HRD68_RS09220	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HRD68_RS09225	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
HRD68_RS09230	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HRD68_RS09235	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HRD68_RS09240	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HRD68_RS09245	COG4942	peptidase
HRD68_RS09250	COG2861	carbohydrate metabolic process
HRD68_RS09260	COG0156	8-amino-7-oxononanoate synthase activity
HRD68_RS09265	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HRD68_RS09270	COG0859	PFAM glycosyl transferase family 9
HRD68_RS09275	COG0859	PFAM glycosyl transferase family 9
HRD68_RS09280	COG1519	Transferase
HRD68_RS09295	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HRD68_RS09300	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HRD68_RS09305	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HRD68_RS09315	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HRD68_RS09320	COG0756	dUTP diphosphatase activity
HRD68_RS09325	COG1309	transcriptional regulator
HRD68_RS09335	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HRD68_RS09345	COG2199	diguanylate cyclase activity
HRD68_RS09345	COG2200	EAL domain
HRD68_RS09350	COG4608	Belongs to the ABC transporter superfamily
HRD68_RS09355	COG0444	Belongs to the ABC transporter superfamily
HRD68_RS09360	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HRD68_RS09365	COG0601	transmembrane transport
HRD68_RS09370	COG0747	negative chemotaxis
HRD68_RS09385	COG2831	hemolysin activation secretion protein
HRD68_RS09395	COG2271	Major facilitator Superfamily
HRD68_RS09400	COG3851	Histidine kinase
HRD68_RS09405	COG2197	response regulator
HRD68_RS09410	COG2194	sulfuric ester hydrolase activity
HRD68_RS09415	COG1764	response to oxidative stress
HRD68_RS09430	COG2986	histidine ammonia-lyase
HRD68_RS09435	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HRD68_RS09440	COG5001	Diguanylate cyclase
HRD68_RS09445	COG1024	Enoyl-CoA hydratase
HRD68_RS09450	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HRD68_RS09460	COG2860	membrane
HRD68_RS09465	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HRD68_RS09475	COG1758	RNA polymerase activity
HRD68_RS09480	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HRD68_RS09485	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HRD68_RS09490	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HRD68_RS09495	COG0786	glutamate:sodium symporter activity
HRD68_RS09500	COG2233	PERMEase
HRD68_RS09505	COG2982	Protein involved in outer membrane biogenesis
HRD68_RS09525	COG0456	acetyltransferase
HRD68_RS09535	COG1295	ribonuclease BN
HRD68_RS09540	COG1011	Hydrolase
HRD68_RS09555	COG3852	Histidine kinase
HRD68_RS09565	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HRD68_RS09570	COG3078	GTPase activator activity
HRD68_RS09575	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HRD68_RS09580	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HRD68_RS09580	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HRD68_RS09585	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HRD68_RS09590	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HRD68_RS09595	COG3084	Protein conserved in bacteria
HRD68_RS09605	COG1763	Mo-molybdopterin cofactor biosynthetic process
HRD68_RS09630	COG2186	Transcriptional regulator
HRD68_RS09635	COG0477	Major facilitator Superfamily
HRD68_RS09640	COG1609	Transcriptional regulator
HRD68_RS09645	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HRD68_RS09650	COG1879	ABC-type sugar transport system periplasmic component
HRD68_RS09655	COG1172	Belongs to the binding-protein-dependent transport system permease family
HRD68_RS09665	COG1869	D-ribose catabolic process
HRD68_RS09670	COG3158	transport of potassium into the cell
HRD68_RS09675	COG0714	Associated with various cellular activities
HRD68_RS09680	COG2425	protein containing a von Willebrand factor type A (vWA) domain
HRD68_RS09690	COG2502	aspartate--ammonia ligase
HRD68_RS09695	COG1522	sequence-specific DNA binding
HRD68_RS09700	COG0716	FMN binding
HRD68_RS09705	COG0445	tRNA wobble uridine modification
HRD68_RS09710	COG0357	Ribosomal RNA small subunit methyltransferase G
HRD68_RS09715	COG3312	ion transport
HRD68_RS09720	COG0356	it plays a direct role in the translocation of protons across the membrane
HRD68_RS09730	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HRD68_RS09735	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HRD68_RS09740	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HRD68_RS09745	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HRD68_RS09750	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HRD68_RS09755	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HRD68_RS09760	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HRD68_RS09770	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HRD68_RS09775	COG0573	inorganic phosphate transmembrane transporter activity
HRD68_RS09780	COG0581	inorganic phosphate transmembrane transporter activity
HRD68_RS09790	COG0704	Plays a role in the regulation of phosphate uptake
HRD68_RS09795	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HRD68_RS09800	COG0765	amino acid transport
HRD68_RS09805	COG0765	amino acid transport
HRD68_RS09810	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HRD68_RS09815	COG2252	PERMEase
HRD68_RS09830	COG4191	Histidine kinase
HRD68_RS09835	COG0431	NADPH-dependent FMN reductase
HRD68_RS09840	COG0840	transmembrane signaling receptor activity
HRD68_RS09845	COG2011	ABC-type metal ion transport system permease component
HRD68_RS09850	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HRD68_RS09880	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HRD68_RS09885	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HRD68_RS09890	COG0706	membrane insertase activity
HRD68_RS09900	COG0594	ribonuclease P activity
HRD68_RS09905	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HRD68_RS09910	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HRD68_RS09915	COG0592	DNA-directed DNA polymerase activity
HRD68_RS09925	COG0187	DNA topoisomerase II activity
HRD68_RS09930	COG0561	phosphatase activity
HRD68_RS09935	COG2423	ornithine cyclodeaminase activity
HRD68_RS09950	COG0823	Involved in the tonB-independent uptake of proteins
HRD68_RS09955	COG5645	(Lipo)protein
HRD68_RS09970	COG2985	domain, Protein
HRD68_RS09970	COG0569	domain protein
HRD68_RS09975	COG3977	Valine--pyruvate aminotransferase
HRD68_RS09980	COG0366	Alpha amylase catalytic
HRD68_RS10000	COG2885	chlorophyll binding
HRD68_RS10015	COG2818	Glycosylase
HRD68_RS10025	COG0752	glycyl-tRNA synthetase alpha subunit
HRD68_RS10030	COG0751	glycine-tRNA ligase activity
HRD68_RS10045	COG3276	selenocysteine insertion sequence binding
HRD68_RS10050	COG1921	L-seryl-tRNASec selenium transferase activity
HRD68_RS10055	COG3058	Necessary for formate dehydrogenase activity
HRD68_RS10060	COG2864	formate dehydrogenase
HRD68_RS10065	COG0437	4 iron, 4 sulfur cluster binding
HRD68_RS10075	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HRD68_RS10080	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HRD68_RS10085	COG0840	transmembrane signaling receptor activity
HRD68_RS10090	COG2258	MOSC domain
HRD68_RS10105	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HRD68_RS10115	COG3722	fumarate hydratase activity
HRD68_RS10120	COG0246	Mannitol dehydrogenase
HRD68_RS10125	COG2213	PTS system mannitol-specific
HRD68_RS10125	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HRD68_RS10130	COG3274	enterobacterial common antigen metabolic process
HRD68_RS10140	COG1335	isochorismatase
HRD68_RS10150	COG3188	usher protein
HRD68_RS10155	COG3121	Chaperone
HRD68_RS10165	COG1070	Carbohydrate kinase
HRD68_RS10170	COG2115	Belongs to the xylose isomerase family
HRD68_RS10175	COG4213	ABC transporter substrate-binding protein
HRD68_RS10185	COG4214	carbohydrate transport
HRD68_RS10190	COG1609	Transcriptional regulator
HRD68_RS10190	COG2207	Transcriptional regulator
HRD68_RS10200	COG0582	viral genome integration into host DNA
HRD68_RS10210	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HRD68_RS10230	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HRD68_RS10285	COG2003	Belongs to the UPF0758 family
HRD68_RS10330	COG4529	Protein conserved in bacteria
HRD68_RS10350	COG1561	YicC-like family, N-terminal region
HRD68_RS10355	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HRD68_RS10360	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HRD68_RS10365	COG1301	dicarboxylic acid transport
HRD68_RS10370	COG0612	Peptidase, M16
HRD68_RS10375	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HRD68_RS10380	COG1942	4-Oxalocrotonate Tautomerase
HRD68_RS10385	COG2200	EAL domain
HRD68_RS10390	COG2982	Protein involved in outer membrane biogenesis
HRD68_RS10395	COG2134	cdp-diacylglycerol pyrophosphatase
HRD68_RS10400	COG1295	ribonuclease BN
HRD68_RS10405	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HRD68_RS10410	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HRD68_RS10425	COG0742	ribosomal rna small subunit methyltransferase
HRD68_RS10440	COG0589	response to stress
HRD68_RS10450	COG0306	phosphate transporter
HRD68_RS10455	COG2081	HI0933 family
HRD68_RS10460	COG2197	response regulator
HRD68_RS10475	COG0583	DNA-binding transcription factor activity
HRD68_RS10480	COG2814	Major facilitator Superfamily
HRD68_RS10490	COG2814	Major facilitator Superfamily
HRD68_RS10500	COG3718	enzyme involved in inositol metabolism
HRD68_RS10520	COG0673	inositol 2-dehydrogenase activity
HRD68_RS10525	COG1082	Xylose isomerase domain protein TIM barrel
HRD68_RS10530	COG1247	-acetyltransferase
HRD68_RS10535	COG1741	Belongs to the pirin family
HRD68_RS10540	COG1609	Transcriptional regulator
HRD68_RS10545	COG2610	gluconate transmembrane transporter activity
HRD68_RS10550	COG3265	gluconokinase activity
HRD68_RS10555	COG2095	MarC family integral membrane protein
HRD68_RS10560	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HRD68_RS10565	COG3275	phosphorelay sensor kinase activity
HRD68_RS10570	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HRD68_RS10575	COG1523	belongs to the glycosyl hydrolase 13 family
HRD68_RS10585	COG0297	glycogen (starch) synthase activity
HRD68_RS10590	COG0058	SHG alpha-glucan phosphorylase activity
HRD68_RS10595	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HRD68_RS10600	COG1349	DNA-binding transcription factor activity
HRD68_RS10605	COG0705	Rhomboid family
HRD68_RS10620	COG2909	trisaccharide binding
HRD68_RS10625	COG0058	SHG alpha-glucan phosphorylase activity
HRD68_RS10630	COG1640	4-alpha-glucanotransferase
HRD68_RS10635	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HRD68_RS10635	COG0316	Belongs to the HesB IscA family
HRD68_RS10640	COG1040	competence protein
HRD68_RS10645	COG0596	Alpha beta hydrolase
HRD68_RS10665	COG1918	ferrous iron import across plasma membrane
HRD68_RS10670	COG2183	response to ionizing radiation
HRD68_RS10675	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HRD68_RS10680	COG0745	RESPONSE REGULATOR receiver
HRD68_RS10700	COG3121	Chaperone
HRD68_RS10705	COG3188	usher protein
HRD68_RS10725	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HRD68_RS10735	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HRD68_RS10740	COG1011	Hydrolase
HRD68_RS10750	COG0494	nUDIX hydrolase
HRD68_RS10755	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HRD68_RS10780	COG4796	Type ii and iii secretion system protein
HRD68_RS10785	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HRD68_RS10805	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HRD68_RS10815	COG0180	Tryptophanyl-tRNA synthetase
HRD68_RS10820	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HRD68_RS10820	COG1648	precorrin-2 dehydrogenase activity
HRD68_RS10835	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HRD68_RS10840	COG0402	S-adenosylhomocysteine deaminase activity
HRD68_RS10845	COG0738	Major facilitator superfamily
HRD68_RS10855	COG4771	TonB-dependent receptor
HRD68_RS10865	COG1486	melibiose metabolic process
HRD68_RS10870	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HRD68_RS10875	COG0433	COG0433 Predicted ATPase
HRD68_RS10920	COG1470	cell adhesion involved in biofilm formation
HRD68_RS10920	COG1388	LysM domain
HRD68_RS10935	COG1289	transmembrane transporter activity
HRD68_RS10945	COG1765	OsmC-like protein
HRD68_RS10950	COG3954	Phosphoribulokinase
HRD68_RS10955	COG3089	Belongs to the UPF0270 family
HRD68_RS10960	COG0429	hydrolase of the alpha beta-hydrolase fold
HRD68_RS10975	COG4521	taurine ABC transporter
HRD68_RS10985	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HRD68_RS10990	COG2175	clavaminate synthase activity
HRD68_RS11000	COG0488	(ABC) transporter
HRD68_RS11005	COG2249	NAD(P)H dehydrogenase (quinone) activity
HRD68_RS11015	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HRD68_RS11020	COG1047	Peptidyl-prolyl cis-trans
HRD68_RS11030	COG0545	Peptidyl-prolyl cis-trans isomerase
HRD68_RS11035	COG2964	Protein conserved in bacteria
HRD68_RS11040	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HRD68_RS11050	COG2168	tRNA wobble position uridine thiolation
HRD68_RS11055	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HRD68_RS11060	COG0049	tRNA binding
HRD68_RS11070	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HRD68_RS11085	COG0051	transcription antitermination factor activity, RNA binding
HRD68_RS11090	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HRD68_RS11095	COG0088	Forms part of the polypeptide exit tunnel
HRD68_RS11100	COG0089	rRNA binding
HRD68_RS11110	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HRD68_RS11115	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HRD68_RS11120	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HRD68_RS11125	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HRD68_RS11130	COG0255	Belongs to the universal ribosomal protein uL29 family
HRD68_RS11135	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HRD68_RS11140	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HRD68_RS11155	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HRD68_RS11165	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HRD68_RS11170	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HRD68_RS11175	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HRD68_RS11180	COG1841	ribosomal large subunit assembly
HRD68_RS11185	COG0200	Binds to the 23S rRNA
HRD68_RS11190	COG0201	protein transport
HRD68_RS11195	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HRD68_RS11200	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HRD68_RS11205	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HRD68_RS11210	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HRD68_RS11220	COG0203	ribosomal protein L17
HRD68_RS11230	COG0789	Transcriptional regulator
HRD68_RS11235	COG3036	rescue of stalled ribosome
HRD68_RS11240	COG1970	mechanosensitive ion channel activity
HRD68_RS11250	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HRD68_RS11250	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HRD68_RS11255	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HRD68_RS11260	COG0242	peptide deformylase activity
HRD68_RS11265	COG0758	DNA mediated transformation
HRD68_RS11275	COG0551	DNA topoisomerase type I activity
HRD68_RS11280	COG0009	L-threonylcarbamoyladenylate synthase
HRD68_RS11285	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HRD68_RS11290	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HRD68_RS11320	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
HRD68_RS11325	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HRD68_RS11330	COG2224	Isocitrate lyase
HRD68_RS11335	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
HRD68_RS11340	COG1414	Transcriptional regulator
HRD68_RS11345	COG0646	methionine synthase
HRD68_RS11345	COG1410	methionine synthase
HRD68_RS11355	COG0527	aspartate kinase activity
HRD68_RS11370	COG3833	ABC-type maltose transport systems, permease component
HRD68_RS11375	COG1175	transmembrane transport
HRD68_RS11380	COG2182	Extracellular solute-binding protein
HRD68_RS11390	COG4580	involved in the transport of maltose and maltodextrins
HRD68_RS11400	COG3161	chorismate lyase activity
HRD68_RS11410	COG2937	Belongs to the GPAT DAPAT family
HRD68_RS11415	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HRD68_RS11420	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HRD68_RS11425	COG3237	CsbD-like
HRD68_RS11430	COG0735	belongs to the Fur family
HRD68_RS11440	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HRD68_RS11465	COG1448	Aminotransferase
HRD68_RS11470	COG2315	Protein conserved in bacteria
HRD68_RS11475	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HRD68_RS11480	COG0629	single-stranded DNA binding
HRD68_RS11500	COG2252	PERMEase
HRD68_RS11505	COG0025	NhaP-type Na H and K H
HRD68_RS11510	COG0583	DNA-binding transcription factor activity
HRD68_RS11515	COG1380	Effector of murein hydrolase LrgA
HRD68_RS11520	COG1346	cytolysis
HRD68_RS11525	COG1126	abc transporter atp-binding protein
HRD68_RS11530	COG0765	amino acid transport
HRD68_RS11535	COG4597	amino acid ABC transporter
HRD68_RS11540	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HRD68_RS11550	COG1560	Kdo2-lipid A biosynthetic process
HRD68_RS11560	COG1129	ABC transporter
HRD68_RS11565	COG1172	Belongs to the binding-protein-dependent transport system permease family
HRD68_RS11575	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HRD68_RS11585	COG0471	metal ion transport
HRD68_RS11590	COG1278	Cold shock
HRD68_RS11595	COG1278	Cold shock
HRD68_RS11600	COG3133	Outer membrane lipoprotein
HRD68_RS11615	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
HRD68_RS11620	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HRD68_RS11625	COG2264	protein methyltransferase activity
HRD68_RS11630	COG4145	pantothenate transmembrane transporter activity
HRD68_RS11635	COG3924	membrane
HRD68_RS11640	COG0439	Biotin carboxylase
HRD68_RS11645	COG0511	ligase activity, forming carbon-carbon bonds
HRD68_RS11655	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
HRD68_RS11665	COG0604	alcohol dehydrogenase
HRD68_RS11670	COG2199	diguanylate cyclase activity
HRD68_RS11670	COG2200	EAL domain
HRD68_RS11675	COG1077	Cell shape determining protein MreB Mrl
HRD68_RS11680	COG1792	Involved in formation and maintenance of cell shape
HRD68_RS11685	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HRD68_RS11690	COG0424	maF-like protein
HRD68_RS11695	COG1530	ribonuclease E activity
HRD68_RS11700	COG3164	Protein of unknown function
HRD68_RS11705	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HRD68_RS11710	COG0312	modulator of DNA gyrase
HRD68_RS11715	COG0583	DNA-binding transcription factor activity
HRD68_RS11725	COG1566	PFAM secretion protein HlyD family protein
HRD68_RS11730	COG1289	transmembrane transporter activity
HRD68_RS11745	COG2732	(Barnase) inhibitor
HRD68_RS11750	COG3028	Belongs to the UPF0307 family
HRD68_RS11755	COG0312	modulator of DNA gyrase
HRD68_RS11765	COG3783	Cytochrome b(562)
HRD68_RS11770	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HRD68_RS11800	COG3964	amidohydrolase
HRD68_RS11815	COG3711	transcriptional antiterminator
HRD68_RS11815	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HRD68_RS11825	COG1609	Transcriptional regulator
HRD68_RS11830	COG1263	PTS System
HRD68_RS11830	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HRD68_RS11835	COG0366	Alpha amylase catalytic
HRD68_RS11865	COG2308	Evidence 4 Homologs of previously reported genes of
HRD68_RS11875	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
HRD68_RS11880	COG0540	Belongs to the ATCase OTCase family
HRD68_RS11885	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HRD68_RS11905	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HRD68_RS11910	COG1137	ATPase activity
HRD68_RS11915	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HRD68_RS11920	COG3117	lipopolysaccharide transmembrane transporter activity
HRD68_RS11925	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HRD68_RS11930	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HRD68_RS11930	COG0517	IMP dehydrogenase activity
HRD68_RS11935	COG0530	calcium, potassium:sodium antiporter activity
HRD68_RS11940	COG1127	ABC transporter
HRD68_RS11945	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HRD68_RS11950	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HRD68_RS11955	COG2854	intermembrane phospholipid transfer
HRD68_RS11960	COG3113	response to antibiotic
HRD68_RS11965	COG5007	Belongs to the BolA IbaG family
HRD68_RS11970	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HRD68_RS11975	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HRD68_RS11980	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HRD68_RS11985	COG3105	Protein conserved in bacteria
HRD68_RS11995	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HRD68_RS12000	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HRD68_RS12005	COG0625	glutathione transferase activity
HRD68_RS12010	COG2969	positive regulation of protein catabolic process
HRD68_RS12020	COG0493	'glutamate synthase
HRD68_RS12025	COG0067	glutamate synthase
HRD68_RS12025	COG0069	glutamate synthase activity
HRD68_RS12025	COG0070	glutamate synthase
HRD68_RS12030	COG1242	4 iron, 4 sulfur cluster binding
HRD68_RS12035	COG2198	Histidine kinase
HRD68_RS12035	COG0784	Response regulator, receiver
HRD68_RS12035	COG5002	protein histidine kinase activity
HRD68_RS12040	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HRD68_RS12045	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HRD68_RS12050	COG2823	Periplasmic or secreted lipoprotein
HRD68_RS12055	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HRD68_RS12060	COG0792	nuclease activity
HRD68_RS12070	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HRD68_RS12105	COG1064	alcohol dehydrogenase
HRD68_RS12110	COG1741	Belongs to the pirin family
HRD68_RS12115	COG0583	DNA-binding transcription factor activity
HRD68_RS12120	COG0435	Glutathione S-transferase
HRD68_RS12125	COG2259	Doxx family
HRD68_RS12135	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
HRD68_RS12140	COG4575	ribosome binding
HRD68_RS12155	COG0586	Pfam SNARE associated Golgi protein
HRD68_RS12170	COG2271	Major facilitator Superfamily
HRD68_RS12175	COG1904	glucuronate isomerase
HRD68_RS12180	COG0246	Mannitol dehydrogenase
HRD68_RS12185	COG2721	sulfolactate sulfo-lyase activity
HRD68_RS12195	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HRD68_RS12200	COG0861	Integral membrane protein TerC family
HRD68_RS12210	COG0673	inositol 2-dehydrogenase activity
HRD68_RS12215	COG1451	nucleotide metabolic process
HRD68_RS12220	COG2813	Specifically methylates the guanine in position
HRD68_RS12230	COG1902	pentaerythritol trinitrate reductase activity
HRD68_RS12230	COG0446	pyridine nucleotide-disulphide oxidoreductase
HRD68_RS12235	COG3247	response to pH
HRD68_RS12245	COG0800	Aldolase
HRD68_RS12250	COG2271	Major facilitator Superfamily
HRD68_RS12265	COG1454	alcohol dehydrogenase
HRD68_RS12270	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HRD68_RS12285	COG4974	Belongs to the 'phage' integrase family
HRD68_RS12345	COG4695	Portal protein
HRD68_RS12420	COG2856	Zn peptidase
HRD68_RS12510	COG0358	DNA primase activity
HRD68_RS12515	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HRD68_RS12520	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HRD68_RS12525	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HRD68_RS12530	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HRD68_RS12535	COG1968	undecaprenyl-diphosphatase activity
HRD68_RS12540	COG0617	tRNA 3'-terminal CCA addition
HRD68_RS12545	COG4991	sh3 domain protein
HRD68_RS12550	COG3025	triphosphatase activity
HRD68_RS12555	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HRD68_RS12560	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HRD68_RS12560	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HRD68_RS12565	COG0531	amino acid
HRD68_RS12575	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HRD68_RS12580	COG3384	dioxygenase
HRD68_RS12585	COG0754	glutathionylspermidine amidase activity
HRD68_RS12590	COG5463	Belongs to the UPF0441 family
HRD68_RS12595	COG1538	Outer membrane efflux protein
HRD68_RS12600	COG0494	nUDIX hydrolase
HRD68_RS12605	COG3151	Protein conserved in bacteria
HRD68_RS12610	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HRD68_RS12615	COG3150	esterase
HRD68_RS12630	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HRD68_RS12635	COG2249	NAD(P)H dehydrogenase (quinone) activity
HRD68_RS12645	COG0204	Acyl-transferase
HRD68_RS12650	COG2132	Multicopper oxidase
HRD68_RS12660	COG0656	L-ascorbic acid biosynthetic process
HRD68_RS12665	COG1979	alcohol dehydrogenase
HRD68_RS12670	COG2207	Transcriptional regulator
HRD68_RS12675	COG0586	Pfam SNARE associated Golgi protein
HRD68_RS12680	COG0626	cystathionine gamma-synthase activity
HRD68_RS12690	COG0848	biopolymer transport protein
HRD68_RS12740	COG4964	Belongs to the GSP D family
HRD68_RS12765	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HRD68_RS12770	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HRD68_RS12795	COG1120	ATPase activity
HRD68_RS12800	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HRD68_RS12805	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HRD68_RS12825	COG1609	Transcriptional regulator
HRD68_RS12835	COG4592	Periplasmic binding protein
HRD68_RS12840	COG0840	transmembrane signaling receptor activity
HRD68_RS12855	COG3710	Transcriptional regulator
HRD68_RS12860	COG3133	Outer membrane lipoprotein
HRD68_RS12865	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
HRD68_RS12870	COG0437	4 iron, 4 sulfur cluster binding
HRD68_RS12875	COG5557	Pfam Polysulphide reductase, NrfD
HRD68_RS12880	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HRD68_RS12885	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HRD68_RS12890	COG1773	rubredoxin
HRD68_RS12900	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HRD68_RS12905	COG0298	carbon dioxide binding
HRD68_RS12910	COG0409	Hydrogenase expression formation protein
HRD68_RS12915	COG0309	Hydrogenase expression formation protein (HypE)
HRD68_RS12920	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HRD68_RS12930	COG5001	Diguanylate cyclase
HRD68_RS12935	COG0471	metal ion transport
HRD68_RS12940	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HRD68_RS12945	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HRD68_RS12955	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HRD68_RS12970	COG4303	Ethanolamine ammonia lyase large subunit
HRD68_RS12975	COG4302	ethanolamine ammonia-lyase activity
HRD68_RS12980	COG0477	Major facilitator Superfamily
HRD68_RS13005	COG1609	Transcriptional regulator
HRD68_RS13010	COG0477	Major facilitator Superfamily
HRD68_RS13015	COG4607	ABC-type enterochelin transport system periplasmic component
HRD68_RS13025	COG4605	iron ion homeostasis
HRD68_RS13030	COG4604	ABC transporter, ATP-binding protein
HRD68_RS13035	COG0024	Methionine aminopeptidase
HRD68_RS13055	COG2222	sugar isomerase
HRD68_RS13060	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HRD68_RS13065	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HRD68_RS13070	COG3716	PTS system mannose fructose sorbose family IID component
HRD68_RS13080	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HRD68_RS13090	COG1349	DNA-binding transcription factor activity
HRD68_RS13095	COG2226	methyltransferase
HRD68_RS13100	COG0747	negative chemotaxis
HRD68_RS13105	COG0601	transmembrane transport
HRD68_RS13110	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HRD68_RS13115	COG0444	Belongs to the ABC transporter superfamily
HRD68_RS13120	COG1124	(ABC) transporter
HRD68_RS13125	COG2831	hemolysin activation secretion protein
HRD68_RS13130	COG3210	domain, Protein
HRD68_RS13210	COG2885	chlorophyll binding
HRD68_RS13240	COG0791	NLP P60 protein
HRD68_RS13240	COG1388	LysM domain
HRD68_RS13300	COG1228	amidohydrolase
HRD68_RS13315	COG1289	transmembrane transporter activity
HRD68_RS13385	COG4964	Belongs to the GSP D family
HRD68_RS13435	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HRD68_RS13455	COG1388	LysM domain
HRD68_RS13455	COG2373	Large extracellular alpha-helical protein
HRD68_RS13455	COG4932	domain protein
HRD68_RS13475	COG0840	transmembrane signaling receptor activity
HRD68_RS13480	COG2197	response regulator
HRD68_RS13505	COG2747	anti-sigma28 factor FlgM
HRD68_RS13515	COG1815	bacterial-type flagellum-dependent cell motility
HRD68_RS13525	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HRD68_RS13565	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HRD68_RS13570	COG1191	sigma factor activity
HRD68_RS13595	COG0643	Histidine kinase
HRD68_RS13595	COG2198	Histidine kinase
HRD68_RS13600	COG0835	chemotaxis
HRD68_RS13645	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HRD68_RS13655	COG0745	RESPONSE REGULATOR receiver
HRD68_RS13665	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HRD68_RS13670	COG1677	Flagellar hook-basal body complex protein FliE
HRD68_RS13675	COG1766	The M ring may be actively involved in energy transduction
HRD68_RS13685	COG1317	bacterial-type flagellum organization
HRD68_RS13690	COG1157	protein secretion by the type III secretion system
HRD68_RS13700	COG3144	bacterial-type flagellum assembly
HRD68_RS13705	COG1580	Controls the rotational direction of flagella during chemotaxis
HRD68_RS13715	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HRD68_RS13730	COG1987	bacterial-type flagellum assembly
HRD68_RS13745	COG0745	RESPONSE REGULATOR receiver
HRD68_RS13770	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HRD68_RS13785	COG0673	inositol 2-dehydrogenase activity
HRD68_RS13790	COG0823	Involved in the tonB-independent uptake of proteins
HRD68_RS13795	COG1653	transport
HRD68_RS13800	COG1082	Xylose isomerase domain protein TIM barrel
HRD68_RS13805	COG0626	cystathionine gamma-synthase activity
HRD68_RS13810	COG0814	amino acid
HRD68_RS13815	COG0583	DNA-binding transcription factor activity
HRD68_RS13825	COG3655	Transcriptional regulator
HRD68_RS13840	COG3121	Chaperone
HRD68_RS13845	COG3188	usher protein
HRD68_RS13860	COG2197	response regulator
HRD68_RS13870	COG1982	Orn Lys Arg decarboxylase major
HRD68_RS13875	COG0741	lytic transglycosylase activity
HRD68_RS13885	COG1194	a g-specific adenine glycosylase
HRD68_RS13890	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HRD68_RS13895	COG3171	Protein conserved in bacteria
HRD68_RS13910	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HRD68_RS13920	COG1872	DUF167
HRD68_RS13925	COG0762	integral membrane protein
HRD68_RS13930	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HRD68_RS13935	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HRD68_RS13940	COG2805	Type II/IV secretion system protein
HRD68_RS13950	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HRD68_RS13955	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HRD68_RS13960	COG1678	Uncharacterized ACR, COG1678
HRD68_RS13965	COG0189	ligase activity
HRD68_RS13970	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HRD68_RS13975	COG2356	endonuclease I
HRD68_RS13980	COG3091	SprT-like family
HRD68_RS13985	COG0640	Transcriptional regulator
HRD68_RS14000	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HRD68_RS14005	COG1166	arginine decarboxylase activity
HRD68_RS14015	COG0501	Belongs to the peptidase M48B family
HRD68_RS14020	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HRD68_RS14025	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HRD68_RS14030	COG0126	phosphoglycerate kinase activity
HRD68_RS14035	COG0191	fructose-bisphosphate aldolase activity
HRD68_RS14050	COG1279	arginine transmembrane transporter activity
HRD68_RS14060	COG0583	DNA-binding transcription factor activity
HRD68_RS14065	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HRD68_RS14070	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HRD68_RS14075	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HRD68_RS14085	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
HRD68_RS14090	COG3079	Belongs to the UPF0149 family
HRD68_RS14095	COG0006	proline dipeptidase activity
HRD68_RS14100	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HRD68_RS14105	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HRD68_RS14110	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HRD68_RS14115	COG0509	glycine decarboxylation via glycine cleavage system
HRD68_RS14120	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HRD68_RS14120	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HRD68_RS14125	COG1028	Short-chain dehydrogenase reductase Sdr
HRD68_RS14130	COG1272	protein, Hemolysin III
HRD68_RS14135	COG0354	folic acid binding
HRD68_RS14150	COG0745	RESPONSE REGULATOR receiver
HRD68_RS14155	COG2205	protein histidine kinase activity
HRD68_RS14160	COG4452	Inner membrane protein CreD
HRD68_RS14165	COG0716	FMN binding
HRD68_RS14170	COG4974	Belongs to the 'phage' integrase family
HRD68_RS14175	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HRD68_RS14180	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HRD68_RS14205	COG0656	L-ascorbic acid biosynthetic process
HRD68_RS14225	COG3706	GGDEF domain
HRD68_RS14230	COG1522	sequence-specific DNA binding
HRD68_RS14245	COG2271	Major facilitator Superfamily
HRD68_RS14255	COG0484	heat shock protein binding
HRD68_RS14265	COG1028	Short-chain dehydrogenase reductase Sdr
HRD68_RS14270	COG1733	regulation of RNA biosynthetic process
HRD68_RS14305	COG0583	DNA-binding transcription factor activity
HRD68_RS14310	COG2814	Major facilitator Superfamily
HRD68_RS14315	COG0583	DNA-binding transcription factor activity
HRD68_RS14325	COG1609	Transcriptional regulator
HRD68_RS14335	COG0204	Acyl-transferase
HRD68_RS14335	COG0318	PFAM AMP-dependent synthetase and ligase
HRD68_RS14340	COG0477	Major facilitator Superfamily
HRD68_RS14345	COG5499	transcription regulator containing HTH domain
HRD68_RS14350	COG0667	Aldo Keto reductase
HRD68_RS14355	COG0861	Integral membrane protein TerC family
HRD68_RS14360	COG3066	DNA modification
HRD68_RS14365	COG1051	belongs to the nudix hydrolase family
HRD68_RS14375	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HRD68_RS14385	COG2165	general secretion pathway protein
HRD68_RS14405	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HRD68_RS14410	COG1025	Belongs to the peptidase M16 family
HRD68_RS14415	COG1074	ATP-dependent DNA helicase activity
HRD68_RS14420	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HRD68_RS14425	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HRD68_RS14425	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HRD68_RS14430	COG0860	N-Acetylmuramoyl-L-alanine amidase
HRD68_RS14450	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HRD68_RS14455	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HRD68_RS14460	COG2166	iron-sulfur cluster assembly
HRD68_RS14465	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HRD68_RS14475	COG0583	DNA-binding transcription factor activity
HRD68_RS14480	COG2363	Small membrane protein
HRD68_RS14485	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
HRD68_RS14495	COG1611	Belongs to the LOG family
HRD68_RS14500	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HRD68_RS14500	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HRD68_RS14510	COG3098	single-species biofilm formation
HRD68_RS14515	COG0564	pseudouridine synthase activity
HRD68_RS14535	COG2171	N-acyltransferase activity
HRD68_RS14540	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HRD68_RS14555	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HRD68_RS14560	COG0528	UMP kinase activity
HRD68_RS14570	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HRD68_RS14580	COG0575	Belongs to the CDS family
HRD68_RS14585	COG0750	zinc metalloprotease
HRD68_RS14595	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
HRD68_RS14600	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HRD68_RS14610	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HRD68_RS14620	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HRD68_RS14625	COG0587	DNA-directed DNA polymerase activity
HRD68_RS14630	COG0825	malonyl-CoA metabolic process
HRD68_RS14635	COG0346	lactoylglutathione lyase activity
HRD68_RS14650	COG4568	rho-dependent transcription termination
HRD68_RS14660	COG4681	YaeQ
HRD68_RS14670	COG3015	lipoprotein NlpE involved in copper resistance
HRD68_RS14675	COG0442	prolyl-tRNA aminoacylation
HRD68_RS14680	COG1720	tRNA m6t6A37 methyltransferase activity
HRD68_RS14690	COG1464	Belongs to the NlpA lipoprotein family
HRD68_RS14695	COG2011	ABC-type metal ion transport system permease component
HRD68_RS14705	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HRD68_RS14740	COG0583	DNA-binding transcription factor activity
HRD68_RS14745	COG0656	L-ascorbic acid biosynthetic process
HRD68_RS14750	COG3021	interspecies interaction between organisms
HRD68_RS14755	COG0741	lytic transglycosylase activity
HRD68_RS14755	COG1388	LysM domain
HRD68_RS14760	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HRD68_RS14765	COG2226	methyltransferase
HRD68_RS14775	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HRD68_RS14785	COG2113	Glycine betaine
HRD68_RS14790	COG4176	ABC-type proline glycine betaine transport system permease component
HRD68_RS14800	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HRD68_RS14810	COG1780	Probably involved in ribonucleotide reductase function
HRD68_RS14820	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HRD68_RS14830	COG4575	ribosome binding
HRD68_RS14855	COG0747	negative chemotaxis
HRD68_RS14865	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HRD68_RS14870	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HRD68_RS14885	COG0831	urea catabolic process
HRD68_RS14890	COG0832	Belongs to the urease beta subunit family
HRD68_RS14895	COG0804	urea catabolic process
HRD68_RS14900	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
HRD68_RS14910	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HRD68_RS14920	COG4413	Urea transporter
HRD68_RS14925	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
HRD68_RS14935	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HRD68_RS14950	COG2133	pyrroloquinoline quinone binding
HRD68_RS14955	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HRD68_RS14960	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HRD68_RS14965	COG1447	Phosphotransferase system cellobiose-specific component IIA
HRD68_RS14970	COG2169	Transcriptional regulator
HRD68_RS14970	COG1917	Cupin 2, conserved barrel domain protein
HRD68_RS14975	COG3394	polysaccharide catabolic process
HRD68_RS14985	COG1595	DNA-templated transcription, initiation
HRD68_RS14990	COG3712	iron ion homeostasis
HRD68_RS14995	COG4772	TonB-dependent receptor
HRD68_RS15000	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HRD68_RS15005	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HRD68_RS15010	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HRD68_RS15015	COG1120	ATPase activity
HRD68_RS15030	COG0789	Transcriptional regulator
HRD68_RS15045	COG0251	oxidation-reduction process
HRD68_RS15050	COG0563	adenylate kinase activity
HRD68_RS15065	COG1401	restriction endodeoxyribonuclease activity
HRD68_RS15115	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HRD68_RS15120	COG2867	negative regulation of translational initiation
HRD68_RS15130	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HRD68_RS15135	COG0497	DNA recombination
HRD68_RS15140	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HRD68_RS15145	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HRD68_RS15150	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HRD68_RS15155	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
HRD68_RS15160	COG0513	Belongs to the DEAD box helicase family
HRD68_RS15165	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HRD68_RS15170	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HRD68_RS15185	COG3026	antisigma factor binding
HRD68_RS15190	COG3086	response to oxidative stress
HRD68_RS15220	COG1381	Involved in DNA repair and RecF pathway recombination
HRD68_RS15225	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HRD68_RS15230	COG0736	holo-[acyl-carrier-protein] synthase activity
HRD68_RS15235	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HRD68_RS15240	COG1737	Transcriptional regulator
HRD68_RS15245	COG0560	Phosphoserine phosphatase
HRD68_RS15255	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HRD68_RS15270	COG2205	protein histidine kinase activity
HRD68_RS15275	COG3170	Tfp pilus assembly protein FimV
HRD68_RS15280	COG2204	response regulator
HRD68_RS15285	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HRD68_RS15285	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HRD68_RS15290	COG0347	Belongs to the P(II) protein family
HRD68_RS15305	COG1735	metal-dependent hydrolase with the TIM-barrel fold
HRD68_RS15310	COG3457	Alanine racemase
HRD68_RS15320	COG2188	Transcriptional regulator
HRD68_RS15325	COG1017	nitric oxide dioxygenase activity
HRD68_RS15325	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HRD68_RS15335	COG2814	Major facilitator Superfamily
HRD68_RS15340	COG3711	transcriptional antiterminator
HRD68_RS15345	COG3683	transport system, periplasmic component
HRD68_RS15350	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
HRD68_RS15355	COG0483	inositol monophosphate 1-phosphatase activity
HRD68_RS15360	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HRD68_RS15365	COG1959	2 iron, 2 sulfur cluster binding
HRD68_RS15375	COG0822	iron-sulfur transferase activity
HRD68_RS15385	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HRD68_RS15390	COG0443	Heat shock 70 kDa protein
HRD68_RS15395	COG0633	Ferredoxin
HRD68_RS15400	COG2975	iron-sulfur cluster assembly
HRD68_RS15415	COG3468	outer membrane autotransporter barrel domain protein
HRD68_RS15420	COG2373	Large extracellular alpha-helical protein
HRD68_RS15425	COG4953	penicillin-binding protein 1C
HRD68_RS15450	COG1426	Protein conserved in bacteria
HRD68_RS15465	COG2976	Protein conserved in bacteria
HRD68_RS15470	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HRD68_RS15475	COG1160	GTP binding
HRD68_RS15485	COG1645	bacterial-type flagellum-dependent swarming motility
HRD68_RS15490	COG1570	exodeoxyribonuclease VII activity
HRD68_RS15495	COG0517	IMP dehydrogenase activity
HRD68_RS15495	COG0516	GMP reductase activity
HRD68_RS15500	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HRD68_RS15500	COG0519	Catalyzes the synthesis of GMP from XMP
HRD68_RS15510	COG3710	Transcriptional regulator
HRD68_RS15520	COG2197	response regulator
HRD68_RS15535	COG3121	Chaperone
HRD68_RS15545	COG3121	Chaperone
HRD68_RS15550	COG3121	Chaperone
HRD68_RS15565	COG0351	phosphomethylpyrimidine kinase
HRD68_RS15585	COG1349	DNA-binding transcription factor activity
HRD68_RS15590	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
HRD68_RS15595	COG1028	Short-chain dehydrogenase reductase Sdr
HRD68_RS15610	COG3730	PTS system glucitol sorbitol-specific
HRD68_RS15615	COG1597	lipid kinase activity
HRD68_RS15625	COG3422	double-strand break repair
HRD68_RS15630	COG0745	RESPONSE REGULATOR receiver
HRD68_RS15635	COG2205	protein histidine kinase activity
HRD68_RS15640	COG0477	Major facilitator Superfamily
HRD68_RS15645	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HRD68_RS15655	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HRD68_RS15680	COG0443	Heat shock 70 kDa protein
HRD68_RS15685	COG5002	protein histidine kinase activity
HRD68_RS15685	COG3447	MASE1 domain protein
HRD68_RS15685	COG5001	Diguanylate cyclase
HRD68_RS15690	COG2239	Acts as a magnesium transporter
HRD68_RS15705	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HRD68_RS15715	COG0581	inorganic phosphate transmembrane transporter activity
HRD68_RS15725	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HRD68_RS15730	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HRD68_RS15740	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HRD68_RS15745	COG2233	PERMEase
HRD68_RS15750	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HRD68_RS15755	COG1393	Belongs to the ArsC family
HRD68_RS15760	COG4783	chaperone-mediated protein folding
HRD68_RS15765	COG0628	permease
HRD68_RS15770	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HRD68_RS15775	COG2716	regulation of RNA biosynthetic process
HRD68_RS15780	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HRD68_RS15785	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HRD68_RS15790	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HRD68_RS15795	COG2321	neutral zinc metallopeptidase
HRD68_RS15800	COG2707	UPF0756 membrane protein
HRD68_RS15805	COG1444	tRNA N-acetyltransferase activity
HRD68_RS15810	COG0400	carboxylic ester hydrolase activity
HRD68_RS15820	COG1876	peptidase activity
HRD68_RS15825	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HRD68_RS15830	COG1393	Belongs to the ArsC family
HRD68_RS15835	COG0583	DNA-binding transcription factor activity
HRD68_RS15840	COG2197	response regulator
HRD68_RS15855	COG1175	transmembrane transport
HRD68_RS15860	COG3842	ATPase activity
HRD68_RS15865	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HRD68_RS15875	COG2197	response regulator
HRD68_RS15880	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
HRD68_RS15880	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HRD68_RS15885	COG3062	negative regulation of establishment of protein localization
HRD68_RS15890	COG0243	molybdopterin cofactor binding
HRD68_RS15895	COG3043	anaerobic respiration
HRD68_RS15900	COG3005	denitrification pathway
HRD68_RS15905	COG0494	nUDIX hydrolase
HRD68_RS15920	COG0408	coproporphyrinogen oxidase activity
HRD68_RS15925	COG0456	acetyltransferase
HRD68_RS15935	COG1129	ABC transporter
HRD68_RS15940	COG1172	Belongs to the binding-protein-dependent transport system permease family
HRD68_RS15965	COG1028	Short-chain dehydrogenase reductase Sdr
HRD68_RS15970	COG3111	PFAM Bacterial OB fold (BOF) protein
HRD68_RS15980	COG2837	iron assimilation
HRD68_RS15985	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HRD68_RS16000	COG2731	YhcH YjgK YiaL family protein
HRD68_RS16005	COG1737	Transcriptional regulator
HRD68_RS16020	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HRD68_RS16025	COG4208	sulfate ABC transporter
HRD68_RS16060	COG1216	Glycosyl transferase, family 2
HRD68_RS16090	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HRD68_RS16095	COG0745	RESPONSE REGULATOR receiver
HRD68_RS16100	COG2205	protein histidine kinase activity
HRD68_RS16115	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HRD68_RS16125	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
HRD68_RS16135	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HRD68_RS16140	COG3530	Putative quorum-sensing-regulated virulence factor
HRD68_RS16165	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HRD68_RS16200	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HRD68_RS16210	COG1914	H( )-stimulated, divalent metal cation uptake system
HRD68_RS16220	COG0667	Aldo Keto reductase
HRD68_RS16225	COG3961	Belongs to the TPP enzyme family
HRD68_RS16240	COG0837	glucose binding
HRD68_RS16245	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
HRD68_RS16255	COG2223	nitrite transmembrane transporter activity
HRD68_RS16260	COG3279	Response regulator of the LytR AlgR family
HRD68_RS16265	COG3275	phosphorelay sensor kinase activity
HRD68_RS16280	COG0436	Aminotransferase
HRD68_RS16285	COG3038	cytochrome b561
HRD68_RS16295	COG1598	PFAM Uncharacterised protein family UPF0150
HRD68_RS16315	COG0406	alpha-ribazole phosphatase activity
HRD68_RS16345	COG3302	dmso reductase anchor subunit
HRD68_RS16350	COG0437	4 iron, 4 sulfur cluster binding
HRD68_RS16355	COG0243	molybdopterin cofactor binding
HRD68_RS16370	COG2951	lytic endotransglycosylase activity
HRD68_RS16375	COG0531	amino acid
HRD68_RS16395	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HRD68_RS16400	COG1127	ABC transporter
HRD68_RS16415	COG3038	cytochrome b561
HRD68_RS16420	COG2353	YceI-like domain
HRD68_RS16425	COG1609	Transcriptional regulator
HRD68_RS16430	COG1263	PTS System
HRD68_RS16430	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HRD68_RS16435	COG2723	6-phospho-beta-galactosidase activity
HRD68_RS16445	COG1695	Transcriptional regulator
HRD68_RS16450	COG2824	Alkylphosphonate utilization operon protein PhnA
HRD68_RS16455	COG2226	methyltransferase
HRD68_RS16460	COG0076	glutamate decarboxylase activity
HRD68_RS16465	COG0531	amino acid
HRD68_RS16480	COG2095	MarC family integral membrane protein
HRD68_RS16490	COG2205	protein histidine kinase activity
HRD68_RS16490	COG2198	Histidine kinase
HRD68_RS16490	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HRD68_RS16490	COG0784	Response regulator, receiver
HRD68_RS16495	COG2197	response regulator
HRD68_RS16500	COG2181	nitrate reductase activity
HRD68_RS16505	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HRD68_RS16510	COG1140	nitrate reductase beta subunit
HRD68_RS16515	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HRD68_RS16520	COG2223	nitrite transmembrane transporter activity
HRD68_RS16525	COG2197	response regulator
HRD68_RS16530	COG3005	denitrification pathway
HRD68_RS16535	COG0243	molybdopterin cofactor binding
HRD68_RS16675	COG0305	Participates in initiation and elongation during chromosome replication
HRD68_RS16745	COG3772	lysozyme
HRD68_RS16770	COG5410	chromosome segregation
HRD68_RS16910	COG0582	viral genome integration into host DNA
HRD68_RS16920	COG2116	formate transmembrane transporter activity
HRD68_RS16930	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HRD68_RS16935	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HRD68_RS16940	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HRD68_RS16945	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
HRD68_RS16950	COG1138	Cytochrome C-type biogenesis protein
HRD68_RS16955	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HRD68_RS16960	COG4235	cytochrome complex assembly
HRD68_RS16960	COG3088	subunit of a heme lyase
HRD68_RS16965	COG4235	cytochrome complex assembly
HRD68_RS16965	COG3088	subunit of a heme lyase
HRD68_RS16990	COG3691	Protein conserved in bacteria
HRD68_RS16995	COG0183	Belongs to the thiolase family
HRD68_RS17000	COG1024	Enoyl-CoA hydratase
HRD68_RS17000	COG1250	3-hydroxyacyl-CoA dehydrogenase
HRD68_RS17005	COG2062	phosphohistidine phosphatase, SixA
HRD68_RS17015	COG2840	Smr protein MutS2
HRD68_RS17020	COG2890	protein-(glutamine-N5) methyltransferase activity
HRD68_RS17030	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
HRD68_RS17035	COG0730	response to heat
HRD68_RS17040	COG3101	peptidyl-lysine hydroxylation
HRD68_RS17050	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HRD68_RS17050	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HRD68_RS17055	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HRD68_RS17065	COG1794	racemase activity, acting on amino acids and derivatives
HRD68_RS17075	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HRD68_RS17090	COG4232	protein-disulfide reductase activity
HRD68_RS17100	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HRD68_RS17125	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HRD68_RS17135	COG0586	Pfam SNARE associated Golgi protein
HRD68_RS17140	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HRD68_RS17145	COG0285	dihydrofolate synthase activity
HRD68_RS17150	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
HRD68_RS17155	COG1286	toxin biosynthetic process
HRD68_RS17160	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HRD68_RS17170	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HRD68_RS17175	COG4215	(ABC) transporter
HRD68_RS17180	COG4160	amino acid transport
HRD68_RS17185	COG4598	ABC transporter
HRD68_RS17190	COG1090	epimerase
HRD68_RS17200	COG0622	Phosphoesterase
HRD68_RS17205	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HRD68_RS17210	COG0561	phosphatase activity
HRD68_RS17215	COG2706	6-phosphogluconolactonase activity
HRD68_RS17225	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HRD68_RS17230	COG0156	8-amino-7-oxononanoate synthase activity
HRD68_RS17235	COG2226	methyltransferase
HRD68_RS17250	COG0556	nucleotide-excision repair
HRD68_RS17255	COG4628	conserved protein (DUF2132)
HRD68_RS17260	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HRD68_RS17265	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HRD68_RS17270	COG0315	cyclic pyranopterin monophosphate synthase activity
HRD68_RS17275	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HRD68_RS17280	COG0314	molybdopterin synthase activity
HRD68_RS17285	COG0670	Belongs to the BI1 family
HRD68_RS17290	COG4774	siderophore transport
HRD68_RS17305	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HRD68_RS17315	COG4592	Periplasmic binding protein
HRD68_RS17320	COG1169	isochorismate synthase
HRD68_RS17325	COG1021	2,3-dihydroxybenzoate-AMP ligase
HRD68_RS17330	COG3433	isochorismatase activity
HRD68_RS17330	COG1535	isochorismatase
HRD68_RS17335	COG1028	Short-chain dehydrogenase reductase Sdr
HRD68_RS17340	COG0842	Transport permease protein
HRD68_RS17345	COG0842	Transport permease protein
HRD68_RS17350	COG1131	(ABC) transporter
HRD68_RS17355	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HRD68_RS17360	COG1309	transcriptional regulator
HRD68_RS17365	COG0513	Belongs to the DEAD box helicase family
HRD68_RS17370	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HRD68_RS17380	COG1686	Belongs to the peptidase S11 family
HRD68_RS17385	COG0277	FAD linked oxidase domain protein
HRD68_RS17405	COG2261	transglycosylase associated protein
HRD68_RS17415	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
HRD68_RS17430	COG4807	Protein conserved in bacteria
HRD68_RS17460	COG2897	thiosulfate sulfurtransferase activity
HRD68_RS17475	COG1732	Glycine betaine
HRD68_RS17480	COG1174	glycine betaine transport
HRD68_RS17485	COG1125	glycine betaine transport
HRD68_RS17490	COG1174	glycine betaine transport
HRD68_RS17500	COG0531	amino acid
HRD68_RS17505	COG1982	Orn Lys Arg decarboxylase major
HRD68_RS17515	COG0697	spore germination
HRD68_RS17530	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HRD68_RS17535	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HRD68_RS17550	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HRD68_RS17555	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
HRD68_RS17565	COG1126	abc transporter atp-binding protein
HRD68_RS17570	COG0765	amino acid transport
HRD68_RS17575	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HRD68_RS17580	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HRD68_RS17585	COG0783	Belongs to the Dps family
HRD68_RS17590	COG4106	trans-aconitate 2-methyltransferase activity
HRD68_RS17605	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HRD68_RS17620	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HRD68_RS17640	COG0488	(ABC) transporter
HRD68_RS17645	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HRD68_RS17650	COG0303	'Molybdopterin
HRD68_RS17660	COG0477	Major facilitator Superfamily
HRD68_RS17675	COG0583	DNA-binding transcription factor activity
HRD68_RS17680	COG0477	Major facilitator Superfamily
HRD68_RS17685	COG0302	gtp cyclohydrolase
HRD68_RS17690	COG2311	Membrane
HRD68_RS17715	COG2116	formate transmembrane transporter activity
HRD68_RS17720	COG3604	Transcriptional regulator
HRD68_RS17725	COG3383	formate dehydrogenase (NAD+) activity
HRD68_RS17730	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HRD68_RS17735	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HRD68_RS17745	COG3260	NADH ubiquinone oxidoreductase 20
HRD68_RS17750	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HRD68_RS17755	COG3261	NADH dehydrogenase
HRD68_RS17755	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
HRD68_RS17760	COG0651	ATP synthesis coupled electron transport
HRD68_RS17765	COG4237	Hydrogenase 4 membrane
HRD68_RS17770	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HRD68_RS17775	COG0650	Formate hydrogenlyase subunit 4
HRD68_RS17780	COG0651	ATP synthesis coupled electron transport
HRD68_RS17785	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HRD68_RS17790	COG0375	protein maturation
HRD68_RS17795	COG0298	carbon dioxide binding
HRD68_RS17800	COG2949	membrane
HRD68_RS17805	COG0281	malic enzyme
HRD68_RS17815	COG1346	cytolysis
HRD68_RS17820	COG1380	Effector of murein hydrolase LrgA
HRD68_RS17825	COG2814	Major facilitator Superfamily
HRD68_RS17840	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HRD68_RS17840	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HRD68_RS17845	COG0489	protein tyrosine kinase activity
HRD68_RS17860	COG2982	Protein involved in outer membrane biogenesis
HRD68_RS17865	COG3069	C4-dicarboxylate transmembrane transporter activity
HRD68_RS17870	COG1253	flavin adenine dinucleotide binding
HRD68_RS17895	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HRD68_RS17905	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HRD68_RS17925	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HRD68_RS17930	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HRD68_RS17935	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HRD68_RS17940	COG0140	phosphoribosyl-ATP diphosphatase activity
HRD68_RS17940	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HRD68_RS17945	COG0107	imidazoleglycerol-phosphate synthase activity
HRD68_RS17950	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HRD68_RS17960	COG0131	Imidazoleglycerol-phosphate dehydratase
HRD68_RS17960	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HRD68_RS17965	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HRD68_RS17970	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HRD68_RS17975	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HRD68_RS17985	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HRD68_RS17990	COG1172	Belongs to the binding-protein-dependent transport system permease family
HRD68_RS17995	COG1129	ABC transporter
HRD68_RS18000	COG0371	Dehydrogenase
HRD68_RS18005	COG0531	amino acid
HRD68_RS18010	COG2925	Exonuclease
HRD68_RS18020	COG1289	transmembrane transporter activity
HRD68_RS18025	COG2926	Belongs to the UPF0265 family
HRD68_RS18035	COG1172	Belongs to the binding-protein-dependent transport system permease family
HRD68_RS18040	COG1129	ABC transporter
HRD68_RS18055	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HRD68_RS18065	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HRD68_RS18085	COG4656	Part of a membrane complex involved in electron transport
HRD68_RS18095	COG1012	belongs to the aldehyde dehydrogenase family
HRD68_RS18180	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
HRD68_RS18190	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
HRD68_RS18255	COG1492	cobalamin metabolic process
HRD68_RS18275	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HRD68_RS18280	COG0583	DNA-binding transcription factor activity
HRD68_RS18290	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HRD68_RS18295	COG2211	Major facilitator Superfamily
HRD68_RS18300	COG0137	argininosuccinate synthase activity
HRD68_RS18305	COG0534	Mate efflux family protein
HRD68_RS18310	COG0835	chemotaxis
HRD68_RS18310	COG0784	Response regulator, receiver
HRD68_RS18315	COG4221	oxidoreductase activity
HRD68_RS18320	COG3550	peptidyl-serine autophosphorylation
HRD68_RS18325	COG3550	peptidyl-serine autophosphorylation
HRD68_RS18365	COG1187	pseudouridine synthase activity
HRD68_RS18370	COG3121	Chaperone
HRD68_RS18385	COG3121	Chaperone
HRD68_RS18395	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HRD68_RS18395	COG2205	protein histidine kinase activity
HRD68_RS18410	COG3842	ATPase activity
HRD68_RS18420	COG1840	ABC-type Fe3 transport system, periplasmic component
HRD68_RS18425	COG2271	Major facilitator Superfamily
HRD68_RS18440	COG4565	transcriptional regulatory protein
HRD68_RS18445	COG3290	protein histidine kinase activity
HRD68_RS18450	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
HRD68_RS18455	COG3052	prosthetic group binding
HRD68_RS18460	COG2301	Belongs to the HpcH HpaI aldolase family
HRD68_RS18465	COG3051	citrate lyase alpha subunit
HRD68_RS18475	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
HRD68_RS18480	COG0471	metal ion transport
HRD68_RS18500	COG0700	Nucleoside recognition
HRD68_RS18505	COG3366	ferrous iron transmembrane transporter activity
HRD68_RS18515	COG0471	metal ion transport
HRD68_RS18520	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HRD68_RS18525	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HRD68_RS18530	COG0583	DNA-binding transcription factor activity
HRD68_RS18540	COG3122	Protein conserved in bacteria
HRD68_RS18595	COG3615	Tellurite resistance protein tehB
HRD68_RS18620	COG0583	DNA-binding transcription factor activity
HRD68_RS18650	COG3228	Belongs to the MtfA family
HRD68_RS18680	COG3321	synthase
HRD68_RS18680	COG1028	Short-chain dehydrogenase reductase Sdr
HRD68_RS18680	COG0604	alcohol dehydrogenase
HRD68_RS18685	COG3250	beta-galactosidase activity
HRD68_RS18690	COG1609	Transcriptional regulator
HRD68_RS18705	COG0840	transmembrane signaling receptor activity
HRD68_RS18710	COG1285	pathogenesis
HRD68_RS18720	COG2130	NADP-dependent
HRD68_RS18725	COG0589	response to stress
HRD68_RS18750	COG0643	Histidine kinase
HRD68_RS18750	COG2198	Histidine kinase
HRD68_RS18755	COG0835	chemotaxis
HRD68_RS18760	COG0840	transmembrane signaling receptor activity
HRD68_RS18765	COG0840	transmembrane signaling receptor activity
HRD68_RS18770	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HRD68_RS18780	COG0745	RESPONSE REGULATOR receiver
HRD68_RS18785	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
HRD68_RS18790	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HRD68_RS18795	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HRD68_RS18810	COG3418	PFAM FlgN family protein
HRD68_RS18815	COG2747	anti-sigma28 factor FlgM
HRD68_RS18825	COG1815	bacterial-type flagellum-dependent cell motility
HRD68_RS18830	COG1558	bacterial-type flagellum-dependent cell motility
HRD68_RS18835	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HRD68_RS18870	COG1256	bacterial-type flagellum assembly
HRD68_RS18890	COG1338	Plays a role in the flagellum-specific transport system
HRD68_RS18925	COG1157	protein secretion by the type III secretion system
HRD68_RS18930	COG1317	bacterial-type flagellum organization
HRD68_RS18945	COG1677	Flagellar hook-basal body complex protein FliE
HRD68_RS18950	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HRD68_RS18955	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HRD68_RS18990	COG1191	sigma factor activity
HRD68_RS19000	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HRD68_RS19030	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HRD68_RS19030	COG0506	proline dehydrogenase activity
HRD68_RS19030	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HRD68_RS19040	COG0672	)-iron permease
HRD68_RS19045	COG2822	iron ion transport
HRD68_RS19065	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
HRD68_RS19070	COG2233	PERMEase
HRD68_RS19075	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HRD68_RS19080	COG0778	Nitroreductase
HRD68_RS19085	COG2267	carboxylic ester hydrolase activity
HRD68_RS19090	COG0251	oxidation-reduction process
HRD68_RS19095	COG1335	isochorismatase
HRD68_RS19100	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HRD68_RS19105	COG1309	transcriptional regulator
HRD68_RS19110	COG1113	amino acid transport
HRD68_RS19120	COG2264	protein methyltransferase activity
HRD68_RS19135	COG0366	Alpha amylase catalytic
HRD68_RS19145	COG3136	membrane protein required for alginate biosynthesis
HRD68_RS19155	COG2197	response regulator
HRD68_RS19160	COG0322	excinuclease ABC activity
HRD68_RS19165	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HRD68_RS19195	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
HRD68_RS19225	COG4626	Terminase
HRD68_RS19225	COG1802	Transcriptional regulator
HRD68_RS19230	COG4725	Belongs to the MT-A70-like family
HRD68_RS19235	COG3645	SOS response
HRD68_RS19235	COG3646	Phage regulatory protein
HRD68_RS19240	COG1403	HNH endonuclease
HRD68_RS19255	COG3179	chitinase
HRD68_RS19295	COG4695	Portal protein
HRD68_RS19425	COG3069	C4-dicarboxylate transmembrane transporter activity
HRD68_RS19430	COG1737	Transcriptional regulator
HRD68_RS19435	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HRD68_RS19465	COG0840	transmembrane signaling receptor activity
HRD68_RS19475	COG2873	o-acetylhomoserine
HRD68_RS19480	COG0702	epimerase
HRD68_RS19485	COG1733	regulation of RNA biosynthetic process
HRD68_RS19500	COG0246	Mannitol dehydrogenase
HRD68_RS19505	COG1063	alcohol dehydrogenase
HRD68_RS19510	COG1802	Transcriptional regulator
HRD68_RS19515	COG2271	Major facilitator Superfamily
HRD68_RS19520	COG0697	spore germination
HRD68_RS19545	COG3706	GGDEF domain
HRD68_RS19545	COG4251	negative regulation of phosphorylation
HRD68_RS19545	COG2203	Gaf domain
HRD68_RS19545	COG5001	Diguanylate cyclase
HRD68_RS19555	COG1132	(ABC) transporter
HRD68_RS19570	COG2207	Transcriptional regulator
HRD68_RS19605	COG1113	amino acid transport
HRD68_RS19630	COG0768	penicillin binding
HRD68_RS19645	COG3447	MASE1 domain protein
HRD68_RS19645	COG5002	protein histidine kinase activity
HRD68_RS19645	COG5001	Diguanylate cyclase
HRD68_RS19655	COG1971	Probably functions as a manganese efflux pump
HRD68_RS19665	COG3716	PTS system mannose fructose sorbose family IID component
HRD68_RS19670	COG3715	PTS system
HRD68_RS19675	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HRD68_RS19675	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HRD68_RS19680	COG1253	flavin adenine dinucleotide binding
HRD68_RS19690	COG1760	l-serine dehydratase
HRD68_RS19695	COG0494	nUDIX hydrolase
HRD68_RS19705	COG3140	Belongs to the UPF0181 family
HRD68_RS19710	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HRD68_RS19715	COG0513	Belongs to the DEAD box helicase family
HRD68_RS19720	COG3141	response to X-ray
HRD68_RS19735	COG1770	oligopeptidase
HRD68_RS19740	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HRD68_RS19760	COG1528	Iron-storage protein
HRD68_RS19765	COG2372	response to copper ion
HRD68_RS19770	COG1276	copper resistance
HRD68_RS19785	COG0346	lactoylglutathione lyase activity
HRD68_RS19825	COG0625	glutathione transferase activity
HRD68_RS19850	COG2203	Gaf domain
HRD68_RS19850	COG5001	Diguanylate cyclase
HRD68_RS19850	COG4251	negative regulation of phosphorylation
HRD68_RS19850	COG3706	GGDEF domain
HRD68_RS19885	COG2814	Major facilitator Superfamily
HRD68_RS19895	COG3008	intermembrane lipid transfer
HRD68_RS19900	COG2995	paraquat-inducible protein a
HRD68_RS19905	COG1956	GAF domain-containing protein
HRD68_RS19910	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
HRD68_RS19915	COG0793	Belongs to the peptidase S41A family
HRD68_RS19920	COG0501	Belongs to the peptidase M48B family
HRD68_RS19925	COG2814	Major facilitator Superfamily
HRD68_RS19930	COG0823	Involved in the tonB-independent uptake of proteins
HRD68_RS19940	COG3023	N-Acetylmuramoyl-L-alanine amidase
HRD68_RS19950	COG1988	membrane-bound metal-dependent
HRD68_RS19955	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HRD68_RS19965	COG3842	ATPase activity
HRD68_RS19970	COG0395	ABC-type sugar transport system, permease component
HRD68_RS19975	COG1175	transmembrane transport
HRD68_RS19985	COG1028	Short-chain dehydrogenase reductase Sdr
HRD68_RS19990	COG1917	Cupin 2, conserved barrel domain protein
HRD68_RS19995	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HRD68_RS20005	COG3001	Fructosamine kinase
HRD68_RS20010	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HRD68_RS20015	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HRD68_RS20020	COG1121	(ABC) transporter
HRD68_RS20025	COG0803	Belongs to the bacterial solute-binding protein 9 family
HRD68_RS20050	COG3623	hexulose-6-phosphate isomerase
HRD68_RS20055	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HRD68_RS20060	COG1070	Carbohydrate kinase
HRD68_RS20080	COG1172	Belongs to the binding-protein-dependent transport system permease family
HRD68_RS20085	COG1129	ABC transporter
HRD68_RS20090	COG1414	Transcriptional regulator
HRD68_RS20095	COG1811	Na channel or pump
HRD68_RS20100	COG4249	Peptidase C14 caspase catalytic subunit p20
HRD68_RS20145	COG0776	regulation of translation
HRD68_RS20150	COG2719	SpoVR family
HRD68_RS20155	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HRD68_RS20160	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HRD68_RS20165	COG0642	Histidine kinase
HRD68_RS20175	COG3111	PFAM Bacterial OB fold (BOF) protein
HRD68_RS20180	COG2814	Major facilitator Superfamily
HRD68_RS20185	COG2202	Pas domain
HRD68_RS20185	COG2199	diguanylate cyclase activity
HRD68_RS20185	COG2200	EAL domain
HRD68_RS20195	COG0583	DNA-binding transcription factor activity
HRD68_RS20205	COG2718	Belongs to the UPF0229 family
HRD68_RS20210	COG2766	serine protein kinase
HRD68_RS20215	COG3713	MltA-interacting MipA family protein
HRD68_RS20245	COG3139	Protein of unknown function (DUF1315)
HRD68_RS20250	COG1335	isochorismatase
HRD68_RS20255	COG0252	asparaginase activity
HRD68_RS20260	COG0616	signal peptide processing
HRD68_RS20265	COG0778	Nitroreductase
HRD68_RS20275	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HRD68_RS20285	COG0494	nUDIX hydrolase
HRD68_RS20290	COG0708	Exodeoxyribonuclease III
HRD68_RS20295	COG0583	DNA-binding transcription factor activity
HRD68_RS20315	COG0788	formyltetrahydrofolate deformylase activity
HRD68_RS20320	COG3012	SEC-C Motif Domain Protein
HRD68_RS20330	COG1752	Esterase of the alpha-beta hydrolase superfamily
HRD68_RS20335	COG0745	RESPONSE REGULATOR receiver
HRD68_RS20345	COG2916	Histone family protein nucleoid-structuring protein H-NS
HRD68_RS20355	COG1454	alcohol dehydrogenase
HRD68_RS20355	COG1012	belongs to the aldehyde dehydrogenase family
HRD68_RS20360	COG2095	MarC family integral membrane protein
HRD68_RS20365	COG4166	transmembrane transport
HRD68_RS20380	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HRD68_RS20385	COG0444	Belongs to the ABC transporter superfamily
HRD68_RS20390	COG4608	Belongs to the ABC transporter superfamily
HRD68_RS20395	COG3099	Belongs to the UPF0263 family
HRD68_RS20400	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HRD68_RS20410	COG2200	EAL domain
HRD68_RS20420	COG2350	Protein conserved in bacteria
HRD68_RS20425	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HRD68_RS20435	COG2917	probably involved in intracellular septation
HRD68_RS20450	COG3047	cAMP biosynthetic process
HRD68_RS20460	COG0159	tryptophan synthase activity
HRD68_RS20465	COG0133	tryptophan synthase activity
HRD68_RS20470	COG0135	phosphoribosylanthranilate isomerase activity
HRD68_RS20470	COG0134	indole-3-glycerol-phosphate synthase activity
HRD68_RS20480	COG0512	Glutamine amidotransferase of anthranilate synthase
HRD68_RS20495	COG0613	PHP domain protein
HRD68_RS20500	COG0009	L-threonylcarbamoyladenylate synthase
HRD68_RS20510	COG2197	response regulator
HRD68_RS20520	COG1187	pseudouridine synthase activity
HRD68_RS20530	COG1028	Short-chain dehydrogenase reductase Sdr
HRD68_RS20535	COG0616	signal peptide processing
HRD68_RS20550	COG0583	DNA-binding transcription factor activity
HRD68_RS20560	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HRD68_RS20570	COG0671	phosphoesterase, PA-phosphatase related
HRD68_RS20575	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
HRD68_RS20580	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HRD68_RS20595	COG0284	orotidine-5'-phosphate decarboxylase activity
HRD68_RS20600	COG0023	Translation Initiation Factor
HRD68_RS20610	COG0235	Class ii aldolase
HRD68_RS20620	COG1349	DNA-binding transcription factor activity
HRD68_RS20635	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HRD68_RS20640	COG2879	small protein
HRD68_RS20645	COG1966	Carbon starvation protein
HRD68_RS20650	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
HRD68_RS20655	COG0243	molybdopterin cofactor binding
HRD68_RS20660	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HRD68_RS20670	COG4659	FMN binding
HRD68_RS20680	COG3708	Transcriptional regulator
HRD68_RS20680	COG2207	Transcriptional regulator
HRD68_RS20695	COG4657	Part of a membrane complex involved in electron transport
HRD68_RS20705	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HRD68_RS20720	COG2274	protein secretion by the type I secretion system
HRD68_RS20725	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HRD68_RS20730	COG2160	L-arabinose isomerase activity
HRD68_RS20740	COG1879	ABC-type sugar transport system periplasmic component
HRD68_RS20745	COG1129	ABC transporter
HRD68_RS20750	COG1172	Belongs to the binding-protein-dependent transport system permease family
HRD68_RS20760	COG0673	inositol 2-dehydrogenase activity
HRD68_RS20765	COG0385	Bile acid
HRD68_RS20770	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HRD68_RS20775	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HRD68_RS20780	COG1263	PTS System
HRD68_RS20780	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HRD68_RS20785	COG1609	Transcriptional regulator
HRD68_RS20805	COG5339	Protein conserved in bacteria
HRD68_RS20815	COG0114	fumarate hydratase activity
HRD68_RS20830	COG2814	Major facilitator Superfamily
HRD68_RS20835	COG0583	DNA-binding transcription factor activity
HRD68_RS20840	COG1940	carbohydrate kinase activity
HRD68_RS20845	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HRD68_RS20865	COG1742	UPF0060 membrane protein
HRD68_RS20870	COG4221	oxidoreductase activity
HRD68_RS20875	COG0477	Major facilitator Superfamily
HRD68_RS20900	COG2211	Major facilitator Superfamily
HRD68_RS20915	COG0625	glutathione transferase activity
HRD68_RS20925	COG1522	sequence-specific DNA binding
HRD68_RS20950	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HRD68_RS20975	COG0076	glutamate decarboxylase activity
HRD68_RS20980	COG0531	amino acid
HRD68_RS20990	COG1011	Hydrolase
HRD68_RS21015	COG1028	Short-chain dehydrogenase reductase Sdr
HRD68_RS21025	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HRD68_RS21040	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HRD68_RS21045	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HRD68_RS21050	COG0589	response to stress
HRD68_RS21055	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HRD68_RS21060	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HRD68_RS21070	COG0531	amino acid
HRD68_RS21080	COG0745	RESPONSE REGULATOR receiver
HRD68_RS21085	COG2205	protein histidine kinase activity
HRD68_RS21090	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HRD68_RS21100	COG3591	Belongs to the peptidase S1B family
HRD68_RS21110	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
HRD68_RS21115	COG1643	Atp-dependent helicase
HRD68_RS21120	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HRD68_RS21125	COG0477	Major facilitator Superfamily
HRD68_RS21135	COG3423	Transcriptional regulator
HRD68_RS21145	COG0246	Mannitol dehydrogenase
HRD68_RS21150	COG1070	Carbohydrate kinase
HRD68_RS21160	COG3784	Protein of unknown function (DUF1318)
HRD68_RS21170	COG2911	Protein conserved in bacteria
HRD68_RS21175	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HRD68_RS21180	COG3042	response to heat
HRD68_RS21190	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HRD68_RS21190	COG0674	pyruvate-flavodoxin oxidoreductase activity
HRD68_RS21190	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HRD68_RS21190	COG1013	pyruvate-flavodoxin oxidoreductase activity
HRD68_RS21195	COG2723	6-phospho-beta-galactosidase activity
HRD68_RS21200	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HRD68_RS21200	COG1263	PTS System
HRD68_RS21200	COG2190	(PTS) system
HRD68_RS21205	COG3711	transcriptional antiterminator
HRD68_RS21210	COG0037	tRNA processing
HRD68_RS21220	COG4166	transmembrane transport
HRD68_RS21225	COG2866	Carboxypeptidase
HRD68_RS21230	COG4948	Mandelate Racemase Muconate Lactonizing
HRD68_RS21235	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HRD68_RS21245	COG5642	Protein of unknown function (DUF2384)
HRD68_RS21250	COG5654	RES domain protein
HRD68_RS21255	COG3768	UPF0283 membrane protein
HRD68_RS21260	COG3106	COG3106 Predicted ATPase
HRD68_RS21270	COG1983	PspC domain protein
HRD68_RS21280	COG1842	Phage shock protein A
HRD68_RS21285	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HRD68_RS21290	COG4166	transmembrane transport
HRD68_RS21300	COG4171	peptide transport system, permease
HRD68_RS21310	COG4172	Belongs to the ABC transporter superfamily
HRD68_RS21315	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HRD68_RS21315	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HRD68_RS21320	COG3104	oligopeptide transport
HRD68_RS21325	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HRD68_RS21345	COG0625	glutathione transferase activity
HRD68_RS21355	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HRD68_RS21365	COG3895	Periplasmic Protein
HRD68_RS21370	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HRD68_RS21375	COG3133	Outer membrane lipoprotein
HRD68_RS21380	COG1846	Transcriptional regulator
HRD68_RS21390	COG1566	PFAM secretion protein HlyD family protein
HRD68_RS21400	COG4989	oxidoreductase activity
HRD68_RS21405	COG3313	Fe-S protein
HRD68_RS21410	COG2194	sulfuric ester hydrolase activity
HRD68_RS21415	COG1309	transcriptional regulator
HRD68_RS21420	COG1902	pentaerythritol trinitrate reductase activity
HRD68_RS21425	COG0346	lactoylglutathione lyase activity
HRD68_RS21430	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HRD68_RS21435	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HRD68_RS21440	COG0791	NLP P60 protein
HRD68_RS21455	COG1609	Transcriptional regulator
HRD68_RS21460	COG0583	DNA-binding transcription factor activity
HRD68_RS21465	COG2814	Major facilitator Superfamily
HRD68_RS21470	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HRD68_RS21475	COG0307	riboflavin synthase, alpha
HRD68_RS21480	COG0534	Mate efflux family protein
HRD68_RS21505	COG1376	ErfK ybiS ycfS ynhG family protein
HRD68_RS21505	COG1388	LysM domain
HRD68_RS21510	COG2166	iron-sulfur cluster assembly
HRD68_RS21520	COG0719	Fe-S assembly protein
HRD68_RS21525	COG0396	ATPase activity
HRD68_RS21530	COG0719	Fe-S assembly protein
HRD68_RS21535	COG0316	Belongs to the HesB IscA family
HRD68_RS21540	COG2050	protein possibly involved in aromatic compounds catabolism
HRD68_RS21545	COG0277	FAD linked oxidase domain protein
HRD68_RS21545	COG0247	lactate metabolic process
HRD68_RS21550	COG0628	permease
HRD68_RS21560	COG0574	Belongs to the PEP-utilizing enzyme family
HRD68_RS21560	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HRD68_RS21565	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HRD68_RS21580	COG0095	Lipoate-protein ligase
HRD68_RS21585	COG0791	NLP P60 protein
HRD68_RS21590	COG2076	Multidrug Resistance protein
HRD68_RS21600	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HRD68_RS21605	COG0726	polysaccharide deacetylase
HRD68_RS21615	COG0463	Glycosyl transferase, family 2
HRD68_RS21620	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HRD68_RS21625	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
HRD68_RS21630	COG0386	Belongs to the glutathione peroxidase family
HRD68_RS21635	COG4139	cobalamin transport
HRD68_RS21645	COG0791	NLP P60 protein
HRD68_RS21650	COG2186	Transcriptional regulator
HRD68_RS21655	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HRD68_RS21660	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HRD68_RS21670	COG2983	Belongs to the UPF0260 family
HRD68_RS21675	COG0179	Fumarylacetoacetate (FAA) hydrolase
HRD68_RS21680	COG3100	YcgL domain-containing protein
HRD68_RS21685	COG0850	regulation of cytokinetic process
HRD68_RS21690	COG2894	cell division
HRD68_RS21695	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HRD68_RS21700	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HRD68_RS21705	COG0318	PFAM AMP-dependent synthetase and ligase
HRD68_RS21710	COG3065	identical protein binding
HRD68_RS21720	COG1199	ATP-dependent helicase activity
HRD68_RS21725	COG0251	oxidation-reduction process
HRD68_RS21730	COG2076	Multidrug Resistance protein
HRD68_RS21735	COG2076	Multidrug Resistance protein
HRD68_RS21740	COG3397	chitin binding
HRD68_RS21745	COG0800	Aldolase
HRD68_RS21750	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HRD68_RS21755	COG1737	Transcriptional regulator
HRD68_RS21760	COG0469	pyruvate kinase activity
HRD68_RS21765	COG1560	Kdo2-lipid A biosynthetic process
HRD68_RS21770	COG0739	heme binding
HRD68_RS21775	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HRD68_RS21780	COG1121	(ABC) transporter
HRD68_RS21785	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HRD68_RS21790	COG2255	four-way junction helicase activity
HRD68_RS21795	COG0632	four-way junction helicase activity
HRD68_RS21805	COG0217	transcriptional regulatory protein
HRD68_RS21810	COG0494	nUDIX hydrolase
HRD68_RS21815	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HRD68_RS21820	COG1335	isochorismatase
HRD68_RS21825	COG1801	Protein of unknown function DUF72
HRD68_RS21830	COG3788	relative of glutathione S-transferase, MAPEG superfamily
HRD68_RS21840	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HRD68_RS21845	COG3142	Participates in the control of copper homeostasis
HRD68_RS21850	COG3102	Protein conserved in bacteria
HRD68_RS21860	COG0728	peptidoglycan biosynthetic process
HRD68_RS21865	COG0673	inositol 2-dehydrogenase activity
HRD68_RS21875	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HRD68_RS21880	COG0477	Major facilitator Superfamily
HRD68_RS21890	COG3381	protein complex oligomerization
HRD68_RS21900	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HRD68_RS21915	COG3706	GGDEF domain
HRD68_RS21920	COG0659	secondary active sulfate transmembrane transporter activity
HRD68_RS21940	COG2890	protein-(glutamine-N5) methyltransferase activity
HRD68_RS21945	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HRD68_RS21950	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HRD68_RS21955	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
HRD68_RS21965	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HRD68_RS21975	COG0193	aminoacyl-tRNA hydrolase activity
HRD68_RS21985	COG0012	GTP binding
HRD68_RS21990	COG0582	viral genome integration into host DNA
HRD68_RS22035	COG4974	Belongs to the 'phage' integrase family
HRD68_RS22040	COG2003	Belongs to the UPF0758 family
HRD68_RS22060	COG3423	Transcriptional regulator
HRD68_RS22120	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HRD68_RS22125	COG2831	hemolysin activation secretion protein
HRD68_RS22130	COG3210	domain, Protein
HRD68_RS22175	COG0786	glutamate:sodium symporter activity
HRD68_RS22180	COG0288	reversible hydration of carbon dioxide
HRD68_RS22210	COG0667	Aldo Keto reductase
HRD68_RS22215	COG0318	PFAM AMP-dependent synthetase and ligase
HRD68_RS22220	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HRD68_RS22225	COG0644	oxidoreductase
HRD68_RS22230	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HRD68_RS22235	COG2086	electron transfer activity
HRD68_RS22240	COG1917	Cupin 2, conserved barrel domain protein
HRD68_RS22240	COG2207	Transcriptional regulator
HRD68_RS22245	COG1960	acyl-CoA dehydrogenase activity
HRD68_RS22250	COG4670	ketone body catabolic process
HRD68_RS22265	COG2271	Major facilitator Superfamily
HRD68_RS22270	COG0583	DNA-binding transcription factor activity
HRD68_RS22275	COG0738	Major facilitator superfamily
HRD68_RS22285	COG4942	peptidase
HRD68_RS22295	COG3443	Belongs to the bacterial solute-binding protein 9 family
HRD68_RS22300	COG4211	Belongs to the binding-protein-dependent transport system permease family
HRD68_RS22305	COG1129	ABC transporter
HRD68_RS22320	COG0402	S-adenosylhomocysteine deaminase activity
HRD68_RS22330	COG1228	amidohydrolase
HRD68_RS22345	COG2988	succinylglutamate desuccinylase activity
HRD68_RS22350	COG3724	N-succinylarginine dihydrolase activity
HRD68_RS22360	COG3138	arginine N-succinyltransferase
HRD68_RS22365	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HRD68_RS22370	COG3866	Pectate lyase
HRD68_RS22375	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HRD68_RS22380	COG1271	oxidase subunit
HRD68_RS22385	COG1294	oxidase, subunit
HRD68_RS22395	COG3850	Histidine kinase
HRD68_RS22410	COG0387	Pfam Sodium calcium exchanger
HRD68_RS22415	COG1702	phosphate starvation-inducible protein PhoH
HRD68_RS22425	COG3658	cytochrome
HRD68_RS22430	COG1215	transferase activity, transferring glycosyl groups
HRD68_RS22435	COG0726	polysaccharide deacetylase
HRD68_RS22435	COG1649	PFAM Uncharacterised BCR, COG1649
HRD68_RS22440	COG0457	Tetratricopeptide repeat
HRD68_RS22445	COG0006	proline dipeptidase activity
HRD68_RS22475	COG0577	efflux transmembrane transporter activity
HRD68_RS22475	COG1136	(ABC) transporter
HRD68_RS22485	COG0577	efflux transmembrane transporter activity
HRD68_RS22485	COG1136	(ABC) transporter
HRD68_RS22500	COG0672	)-iron permease
HRD68_RS22510	COG1447	Phosphotransferase system cellobiose-specific component IIA
HRD68_RS22515	COG2723	6-phospho-beta-galactosidase activity
HRD68_RS22520	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HRD68_RS22520	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HRD68_RS22525	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HRD68_RS22530	COG1609	Transcriptional regulator
HRD68_RS22545	COG2066	Belongs to the glutaminase family
HRD68_RS22550	COG3290	protein histidine kinase activity
HRD68_RS22555	COG4565	transcriptional regulatory protein
HRD68_RS22560	COG3493	citrate carrier protein
HRD68_RS22570	COG3189	MarR family transcriptional regulator
HRD68_RS22580	COG2223	nitrite transmembrane transporter activity
HRD68_RS22585	COG0561	phosphatase activity
HRD68_RS22605	COG0538	isocitrate dehydrogenase activity
HRD68_RS22610	COG1187	pseudouridine synthase activity
HRD68_RS22620	COG0482	sulfurtransferase activity
HRD68_RS22625	COG2915	High frequency lysogenization protein hflD homolog
HRD68_RS22630	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HRD68_RS22640	COG0745	RESPONSE REGULATOR receiver
HRD68_RS22645	COG2205	protein histidine kinase activity
HRD68_RS22650	COG2850	peptidyl-arginine hydroxylation
HRD68_RS22665	COG1940	carbohydrate kinase activity
HRD68_RS22670	COG4591	ABC-type transport system involved in lipoprotein release permease component
HRD68_RS22680	COG4591	ABC-type transport system involved in lipoprotein release permease component
HRD68_RS22685	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HRD68_RS22690	COG3134	Outer membrane lipoprotein
HRD68_RS22695	COG1252	NADH dehydrogenase
HRD68_RS22700	COG3150	esterase
HRD68_RS22715	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
HRD68_RS22720	COG5633	Lipoprotein
HRD68_RS22725	COG0537	adenosine 5'-monophosphoramidase activity
HRD68_RS22730	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HRD68_RS22740	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HRD68_RS22740	COG1263	PTS System
HRD68_RS22745	COG0084	hydrolase, TatD family'
HRD68_RS22750	COG0470	DNA polymerase III
HRD68_RS22755	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HRD68_RS22760	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HRD68_RS22765	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HRD68_RS22770	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HRD68_RS22795	COG0416	fatty acid biosynthetic process
HRD68_RS22800	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HRD68_RS22805	COG1399	metal-binding, possibly nucleic acid-binding protein
HRD68_RS22815	COG0564	pseudouridine synthase activity
HRD68_RS22820	COG1530	ribonuclease E activity
HRD68_RS22825	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HRD68_RS22830	COG0418	dihydroorotase activity
HRD68_RS22850	COG2197	response regulator
HRD68_RS22860	COG0628	permease
HRD68_RS22870	COG0697	spore germination
HRD68_RS22905	COG1560	Kdo2-lipid A biosynthetic process
HRD68_RS22910	COG2259	Doxx family
HRD68_RS22915	COG2814	Major facilitator Superfamily
HRD68_RS22920	COG3104	oligopeptide transport
HRD68_RS22930	COG5645	(Lipo)protein
HRD68_RS22935	COG2943	transferase activity, transferring hexosyl groups
HRD68_RS22940	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
HRD68_RS22955	COG3263	regulation of cellular component size
HRD68_RS22965	COG3916	Acyl-homoserine-lactone synthase
HRD68_RS22970	COG2771	luxR family
HRD68_RS22975	COG3088	subunit of a heme lyase
HRD68_RS22975	COG4235	cytochrome complex assembly
HRD68_RS22980	COG3088	subunit of a heme lyase
HRD68_RS22985	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HRD68_RS22990	COG1138	Cytochrome C-type biogenesis protein
HRD68_RS22995	COG3301	Polysulphide reductase, NrfD
HRD68_RS23000	COG0437	4 iron, 4 sulfur cluster binding
HRD68_RS23005	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
HRD68_RS23030	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HRD68_RS23035	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HRD68_RS23040	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HRD68_RS23040	COG1263	PTS System
HRD68_RS23050	COG0698	ribose 5-phosphate isomerase
HRD68_RS23055	COG1737	Transcriptional regulator
HRD68_RS23060	COG1879	ABC-type sugar transport system periplasmic component
HRD68_RS23065	COG1129	ABC transporter
HRD68_RS23070	COG1172	Belongs to the binding-protein-dependent transport system permease family
HRD68_RS23075	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HRD68_RS23080	COG1940	carbohydrate kinase activity
HRD68_RS23085	COG1349	DNA-binding transcription factor activity
HRD68_RS23095	COG0738	Major facilitator superfamily
HRD68_RS23130	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1