locus-tag	class	description
DA391_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DA391_RS00010	COG0592	DNA-directed DNA polymerase activity
DA391_RS00020	COG0187	DNA topoisomerase II activity
DA391_RS00025	COG0561	phosphatase activity
DA391_RS00035	COG2423	ornithine cyclodeaminase activity
DA391_RS00050	COG0823	Involved in the tonB-independent uptake of proteins
DA391_RS00055	COG5645	(Lipo)protein
DA391_RS00070	COG0569	domain protein
DA391_RS00070	COG2985	domain, Protein
DA391_RS00075	COG3977	Valine--pyruvate aminotransferase
DA391_RS00080	COG0366	Alpha amylase catalytic
DA391_RS00100	COG2885	chlorophyll binding
DA391_RS00115	COG2818	Glycosylase
DA391_RS00125	COG0752	glycyl-tRNA synthetase alpha subunit
DA391_RS00130	COG0751	glycine-tRNA ligase activity
DA391_RS00150	COG3276	selenocysteine insertion sequence binding
DA391_RS00155	COG1921	L-seryl-tRNASec selenium transferase activity
DA391_RS00160	COG3058	Necessary for formate dehydrogenase activity
DA391_RS00165	COG2864	formate dehydrogenase
DA391_RS00170	COG0437	4 iron, 4 sulfur cluster binding
DA391_RS00180	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
DA391_RS00185	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DA391_RS00195	COG0840	transmembrane signaling receptor activity
DA391_RS00200	COG2258	MOSC domain
DA391_RS00215	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DA391_RS00225	COG3722	fumarate hydratase activity
DA391_RS00230	COG0246	Mannitol dehydrogenase
DA391_RS00235	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
DA391_RS00235	COG2213	PTS system mannitol-specific
DA391_RS00240	COG3274	enterobacterial common antigen metabolic process
DA391_RS00250	COG1335	isochorismatase
DA391_RS00260	COG3188	usher protein
DA391_RS00265	COG3121	Chaperone
DA391_RS00275	COG1070	Carbohydrate kinase
DA391_RS00280	COG2115	Belongs to the xylose isomerase family
DA391_RS00285	COG4213	ABC transporter substrate-binding protein
DA391_RS00295	COG4214	carbohydrate transport
DA391_RS00300	COG1609	Transcriptional regulator
DA391_RS00300	COG2207	Transcriptional regulator
DA391_RS00315	COG0232	Belongs to the dGTPase family. Type 2 subfamily
DA391_RS00335	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
DA391_RS00390	COG2003	Belongs to the UPF0758 family
DA391_RS00440	COG4529	Protein conserved in bacteria
DA391_RS00460	COG1561	YicC-like family, N-terminal region
DA391_RS00465	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
DA391_RS00470	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DA391_RS00475	COG1301	dicarboxylic acid transport
DA391_RS00480	COG0612	Peptidase, M16
DA391_RS00485	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DA391_RS00495	COG1942	4-Oxalocrotonate Tautomerase
DA391_RS00500	COG2200	EAL domain
DA391_RS00505	COG2982	Protein involved in outer membrane biogenesis
DA391_RS00510	COG2134	cdp-diacylglycerol pyrophosphatase
DA391_RS00515	COG1295	ribonuclease BN
DA391_RS00520	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DA391_RS00525	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
DA391_RS00540	COG0742	ribosomal rna small subunit methyltransferase
DA391_RS00555	COG0589	response to stress
DA391_RS00565	COG0306	phosphate transporter
DA391_RS00570	COG2081	HI0933 family
DA391_RS00575	COG2197	response regulator
DA391_RS00590	COG0583	DNA-binding transcription factor activity
DA391_RS00595	COG2814	Major facilitator Superfamily
DA391_RS00605	COG2814	Major facilitator Superfamily
DA391_RS00615	COG3718	enzyme involved in inositol metabolism
DA391_RS00635	COG0673	inositol 2-dehydrogenase activity
DA391_RS00640	COG1082	Xylose isomerase domain protein TIM barrel
DA391_RS00650	COG1247	-acetyltransferase
DA391_RS00655	COG1741	Belongs to the pirin family
DA391_RS00660	COG1609	Transcriptional regulator
DA391_RS00665	COG2610	gluconate transmembrane transporter activity
DA391_RS00670	COG3265	gluconokinase activity
DA391_RS00675	COG2095	MarC family integral membrane protein
DA391_RS00680	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
DA391_RS00685	COG3275	phosphorelay sensor kinase activity
DA391_RS00690	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
DA391_RS00695	COG1523	belongs to the glycosyl hydrolase 13 family
DA391_RS00705	COG0297	glycogen (starch) synthase activity
DA391_RS00710	COG0058	SHG alpha-glucan phosphorylase activity
DA391_RS00715	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
DA391_RS00730	COG1349	DNA-binding transcription factor activity
DA391_RS00735	COG0705	Rhomboid family
DA391_RS00750	COG2909	trisaccharide binding
DA391_RS00755	COG0058	SHG alpha-glucan phosphorylase activity
DA391_RS00760	COG1640	4-alpha-glucanotransferase
DA391_RS00765	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
DA391_RS00765	COG0316	Belongs to the HesB IscA family
DA391_RS00770	COG1040	competence protein
DA391_RS00775	COG0596	Alpha beta hydrolase
DA391_RS00795	COG1918	ferrous iron import across plasma membrane
DA391_RS00800	COG2183	response to ionizing radiation
DA391_RS00805	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DA391_RS00830	COG3121	Chaperone
DA391_RS00835	COG3188	usher protein
DA391_RS00855	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
DA391_RS00865	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
DA391_RS00870	COG1011	Hydrolase
DA391_RS00880	COG0494	nUDIX hydrolase
DA391_RS00885	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
DA391_RS00910	COG4796	Type ii and iii secretion system protein
DA391_RS00915	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DA391_RS00935	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DA391_RS00945	COG0180	Tryptophanyl-tRNA synthetase
DA391_RS00950	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DA391_RS00950	COG1648	precorrin-2 dehydrogenase activity
DA391_RS00965	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DA391_RS00975	COG0402	S-adenosylhomocysteine deaminase activity
DA391_RS00980	COG0738	Major facilitator superfamily
DA391_RS00990	COG4771	TonB-dependent receptor
DA391_RS01000	COG1486	melibiose metabolic process
DA391_RS01005	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DA391_RS01010	COG0433	COG0433 Predicted ATPase
DA391_RS01055	COG1470	cell adhesion involved in biofilm formation
DA391_RS01055	COG1388	LysM domain
DA391_RS01070	COG1289	transmembrane transporter activity
DA391_RS01080	COG1765	OsmC-like protein
DA391_RS01085	COG3954	Phosphoribulokinase
DA391_RS01090	COG3089	Belongs to the UPF0270 family
DA391_RS01095	COG0429	hydrolase of the alpha beta-hydrolase fold
DA391_RS01110	COG4521	taurine ABC transporter
DA391_RS01120	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DA391_RS01125	COG2175	clavaminate synthase activity
DA391_RS01135	COG0488	(ABC) transporter
DA391_RS01140	COG2249	NAD(P)H dehydrogenase (quinone) activity
DA391_RS01150	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
DA391_RS01155	COG1047	Peptidyl-prolyl cis-trans
DA391_RS01165	COG0545	Peptidyl-prolyl cis-trans isomerase
DA391_RS01170	COG2964	Protein conserved in bacteria
DA391_RS01175	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
DA391_RS01185	COG2168	tRNA wobble position uridine thiolation
DA391_RS01190	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DA391_RS01195	COG0049	tRNA binding
DA391_RS01210	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DA391_RS01225	COG0051	transcription antitermination factor activity, RNA binding
DA391_RS01230	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DA391_RS01235	COG0088	Forms part of the polypeptide exit tunnel
DA391_RS01240	COG0089	rRNA binding
DA391_RS01250	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DA391_RS01255	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
DA391_RS01260	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DA391_RS01265	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
DA391_RS01270	COG0255	Belongs to the universal ribosomal protein uL29 family
DA391_RS01275	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
DA391_RS01280	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
DA391_RS01295	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DA391_RS01305	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DA391_RS01310	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
DA391_RS01315	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
DA391_RS01320	COG1841	ribosomal large subunit assembly
DA391_RS01325	COG0200	Binds to the 23S rRNA
DA391_RS01330	COG0201	protein transport
DA391_RS01335	COG0257	Belongs to the bacterial ribosomal protein bL36 family
DA391_RS01340	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DA391_RS01345	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
DA391_RS01350	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DA391_RS01360	COG0203	ribosomal protein L17
DA391_RS01370	COG0789	Transcriptional regulator
DA391_RS01375	COG3036	rescue of stalled ribosome
DA391_RS01380	COG1970	mechanosensitive ion channel activity
DA391_RS01390	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DA391_RS01390	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DA391_RS01395	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DA391_RS01400	COG0242	peptide deformylase activity
DA391_RS01405	COG0758	DNA mediated transformation
DA391_RS01415	COG0551	DNA topoisomerase type I activity
DA391_RS01420	COG0009	L-threonylcarbamoyladenylate synthase
DA391_RS01425	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DA391_RS01430	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
DA391_RS01470	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
DA391_RS01475	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
DA391_RS01480	COG2224	Isocitrate lyase
DA391_RS01485	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
DA391_RS01490	COG1414	Transcriptional regulator
DA391_RS01495	COG1410	methionine synthase
DA391_RS01495	COG0646	methionine synthase
DA391_RS01505	COG0527	aspartate kinase activity
DA391_RS01520	COG3833	ABC-type maltose transport systems, permease component
DA391_RS01525	COG1175	transmembrane transport
DA391_RS01530	COG2182	Extracellular solute-binding protein
DA391_RS01545	COG4580	involved in the transport of maltose and maltodextrins
DA391_RS01555	COG3161	chorismate lyase activity
DA391_RS01565	COG2937	Belongs to the GPAT DAPAT family
DA391_RS01570	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
DA391_RS01575	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DA391_RS01580	COG3237	CsbD-like
DA391_RS01585	COG0735	belongs to the Fur family
DA391_RS01595	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DA391_RS01620	COG1448	Aminotransferase
DA391_RS01625	COG2315	Protein conserved in bacteria
DA391_RS01630	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DA391_RS01635	COG0629	single-stranded DNA binding
DA391_RS01655	COG2252	PERMEase
DA391_RS01660	COG0025	NhaP-type Na H and K H
DA391_RS01665	COG0583	DNA-binding transcription factor activity
DA391_RS01670	COG1380	Effector of murein hydrolase LrgA
DA391_RS01675	COG1346	cytolysis
DA391_RS01680	COG1126	abc transporter atp-binding protein
DA391_RS01685	COG0765	amino acid transport
DA391_RS01690	COG4597	amino acid ABC transporter
DA391_RS01695	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DA391_RS01705	COG1560	Kdo2-lipid A biosynthetic process
DA391_RS01715	COG1129	ABC transporter
DA391_RS01720	COG1172	Belongs to the binding-protein-dependent transport system permease family
DA391_RS01730	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DA391_RS01740	COG0471	metal ion transport
DA391_RS01745	COG1278	Cold shock
DA391_RS01750	COG1278	Cold shock
DA391_RS01760	COG3133	Outer membrane lipoprotein
DA391_RS01775	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
DA391_RS01780	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DA391_RS01785	COG2264	protein methyltransferase activity
DA391_RS01790	COG4145	pantothenate transmembrane transporter activity
DA391_RS01795	COG3924	membrane
DA391_RS01800	COG0439	Biotin carboxylase
DA391_RS01805	COG0511	ligase activity, forming carbon-carbon bonds
DA391_RS01815	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
DA391_RS01825	COG0604	alcohol dehydrogenase
DA391_RS01830	COG2200	EAL domain
DA391_RS01830	COG2199	diguanylate cyclase activity
DA391_RS01835	COG1077	Cell shape determining protein MreB Mrl
DA391_RS01840	COG1792	Involved in formation and maintenance of cell shape
DA391_RS01845	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
DA391_RS01850	COG0424	maF-like protein
DA391_RS01855	COG1530	ribonuclease E activity
DA391_RS01860	COG3164	Protein of unknown function
DA391_RS01865	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DA391_RS01870	COG0312	modulator of DNA gyrase
DA391_RS01875	COG0583	DNA-binding transcription factor activity
DA391_RS01885	COG1566	PFAM secretion protein HlyD family protein
DA391_RS01890	COG1289	transmembrane transporter activity
DA391_RS01905	COG2732	(Barnase) inhibitor
DA391_RS01910	COG3028	Belongs to the UPF0307 family
DA391_RS01915	COG0312	modulator of DNA gyrase
DA391_RS01925	COG3783	Cytochrome b(562)
DA391_RS01930	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DA391_RS01960	COG3964	amidohydrolase
DA391_RS01975	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DA391_RS01975	COG3711	transcriptional antiterminator
DA391_RS01995	COG1609	Transcriptional regulator
DA391_RS02000	COG1263	PTS System
DA391_RS02000	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DA391_RS02005	COG0366	Alpha amylase catalytic
DA391_RS02030	COG2308	Evidence 4 Homologs of previously reported genes of
DA391_RS02040	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
DA391_RS02045	COG0540	Belongs to the ATCase OTCase family
DA391_RS02055	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DA391_RS02075	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
DA391_RS02080	COG1137	ATPase activity
DA391_RS02085	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
DA391_RS02090	COG3117	lipopolysaccharide transmembrane transporter activity
DA391_RS02095	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
DA391_RS02100	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
DA391_RS02100	COG0517	IMP dehydrogenase activity
DA391_RS02105	COG0530	calcium, potassium:sodium antiporter activity
DA391_RS02110	COG1127	ABC transporter
DA391_RS02115	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
DA391_RS02120	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
DA391_RS02125	COG2854	intermembrane phospholipid transfer
DA391_RS02130	COG3113	response to antibiotic
DA391_RS02135	COG5007	Belongs to the BolA IbaG family
DA391_RS02140	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DA391_RS02145	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DA391_RS02150	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DA391_RS02155	COG3105	Protein conserved in bacteria
DA391_RS02160	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
DA391_RS02165	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DA391_RS02170	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DA391_RS02180	COG0625	glutathione transferase activity
DA391_RS02185	COG2969	positive regulation of protein catabolic process
DA391_RS02195	COG0493	'glutamate synthase
DA391_RS02200	COG0070	glutamate synthase
DA391_RS02200	COG0067	glutamate synthase
DA391_RS02200	COG0069	glutamate synthase activity
DA391_RS02205	COG1242	4 iron, 4 sulfur cluster binding
DA391_RS02210	COG0784	Response regulator, receiver
DA391_RS02210	COG2198	Histidine kinase
DA391_RS02210	COG5002	protein histidine kinase activity
DA391_RS02220	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
DA391_RS02225	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DA391_RS02230	COG2823	Periplasmic or secreted lipoprotein
DA391_RS02235	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
DA391_RS02240	COG0792	nuclease activity
DA391_RS02250	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
DA391_RS02285	COG1064	alcohol dehydrogenase
DA391_RS02290	COG1741	Belongs to the pirin family
DA391_RS02295	COG0583	DNA-binding transcription factor activity
DA391_RS02300	COG0435	Glutathione S-transferase
DA391_RS02305	COG2259	Doxx family
DA391_RS02315	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
DA391_RS02320	COG4575	ribosome binding
DA391_RS02335	COG0586	Pfam SNARE associated Golgi protein
DA391_RS02350	COG2271	Major facilitator Superfamily
DA391_RS02355	COG1904	glucuronate isomerase
DA391_RS02360	COG0246	Mannitol dehydrogenase
DA391_RS02365	COG2721	sulfolactate sulfo-lyase activity
DA391_RS02375	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
DA391_RS02380	COG0861	Integral membrane protein TerC family
DA391_RS02390	COG0673	inositol 2-dehydrogenase activity
DA391_RS02395	COG1451	nucleotide metabolic process
DA391_RS02400	COG2813	Specifically methylates the guanine in position
DA391_RS02410	COG1902	pentaerythritol trinitrate reductase activity
DA391_RS02410	COG0446	pyridine nucleotide-disulphide oxidoreductase
DA391_RS02415	COG3247	response to pH
DA391_RS02425	COG0800	Aldolase
DA391_RS02430	COG2271	Major facilitator Superfamily
DA391_RS02445	COG1454	alcohol dehydrogenase
DA391_RS02450	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DA391_RS02465	COG4974	Belongs to the 'phage' integrase family
DA391_RS02530	COG4695	Portal protein
DA391_RS02605	COG2856	Zn peptidase
DA391_RS02665	COG0210	DNA helicase
DA391_RS02720	COG0358	DNA primase activity
DA391_RS02725	COG0828	Belongs to the bacterial ribosomal protein bS21 family
DA391_RS02730	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DA391_RS02735	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
DA391_RS02740	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
DA391_RS02745	COG1968	undecaprenyl-diphosphatase activity
DA391_RS02750	COG0617	tRNA 3'-terminal CCA addition
DA391_RS02755	COG4991	sh3 domain protein
DA391_RS02760	COG3025	triphosphatase activity
DA391_RS02765	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
DA391_RS02770	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
DA391_RS02770	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
DA391_RS02780	COG0531	amino acid
DA391_RS02790	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DA391_RS02795	COG3384	dioxygenase
DA391_RS02800	COG0754	glutathionylspermidine amidase activity
DA391_RS02805	COG5463	Belongs to the UPF0441 family
DA391_RS02810	COG1538	Outer membrane efflux protein
DA391_RS02815	COG0494	nUDIX hydrolase
DA391_RS02820	COG3151	Protein conserved in bacteria
DA391_RS02825	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
DA391_RS02830	COG3150	esterase
DA391_RS02845	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
DA391_RS02850	COG2249	NAD(P)H dehydrogenase (quinone) activity
DA391_RS02860	COG0204	Acyl-transferase
DA391_RS02870	COG2132	Multicopper oxidase
DA391_RS02885	COG0656	L-ascorbic acid biosynthetic process
DA391_RS02890	COG1979	alcohol dehydrogenase
DA391_RS02895	COG2207	Transcriptional regulator
DA391_RS02900	COG0586	Pfam SNARE associated Golgi protein
DA391_RS02905	COG0626	cystathionine gamma-synthase activity
DA391_RS02915	COG0848	biopolymer transport protein
DA391_RS02965	COG4964	Belongs to the GSP D family
DA391_RS02990	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DA391_RS02995	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DA391_RS03030	COG1120	ATPase activity
DA391_RS03035	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DA391_RS03040	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DA391_RS03060	COG1609	Transcriptional regulator
DA391_RS03065	COG4592	Periplasmic binding protein
DA391_RS03070	COG0840	transmembrane signaling receptor activity
DA391_RS03085	COG3133	Outer membrane lipoprotein
DA391_RS03090	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
DA391_RS03095	COG0437	4 iron, 4 sulfur cluster binding
DA391_RS03100	COG5557	Pfam Polysulphide reductase, NrfD
DA391_RS03105	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
DA391_RS03110	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
DA391_RS03115	COG1773	rubredoxin
DA391_RS03125	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
DA391_RS03130	COG0298	carbon dioxide binding
DA391_RS03135	COG0409	Hydrogenase expression formation protein
DA391_RS03140	COG0309	Hydrogenase expression formation protein (HypE)
DA391_RS03145	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
DA391_RS03160	COG0471	metal ion transport
DA391_RS03165	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
DA391_RS03170	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
DA391_RS03180	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DA391_RS03195	COG4303	Ethanolamine ammonia lyase large subunit
DA391_RS03200	COG4302	ethanolamine ammonia-lyase activity
DA391_RS03205	COG0477	Major facilitator Superfamily
DA391_RS03230	COG1609	Transcriptional regulator
DA391_RS03235	COG0477	Major facilitator Superfamily
DA391_RS03240	COG4607	ABC-type enterochelin transport system periplasmic component
DA391_RS03250	COG4605	iron ion homeostasis
DA391_RS03255	COG4604	ABC transporter, ATP-binding protein
DA391_RS03260	COG0024	Methionine aminopeptidase
DA391_RS03280	COG2222	sugar isomerase
DA391_RS03285	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
DA391_RS03290	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
DA391_RS03295	COG3716	PTS system mannose fructose sorbose family IID component
DA391_RS03305	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DA391_RS03320	COG1349	DNA-binding transcription factor activity
DA391_RS03325	COG2226	methyltransferase
DA391_RS03330	COG0747	negative chemotaxis
DA391_RS03335	COG0601	transmembrane transport
DA391_RS03340	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DA391_RS03345	COG0444	Belongs to the ABC transporter superfamily
DA391_RS03350	COG1124	(ABC) transporter
DA391_RS03355	COG2831	hemolysin activation secretion protein
DA391_RS03370	COG3210	domain, Protein
DA391_RS03440	COG2885	chlorophyll binding
DA391_RS03470	COG1388	LysM domain
DA391_RS03470	COG0791	NLP P60 protein
DA391_RS03530	COG1228	amidohydrolase
DA391_RS03545	COG1289	transmembrane transporter activity
DA391_RS03615	COG4964	Belongs to the GSP D family
DA391_RS03665	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DA391_RS03690	COG2373	Large extracellular alpha-helical protein
DA391_RS03690	COG4932	domain protein
DA391_RS03690	COG1388	LysM domain
DA391_RS03720	COG0840	transmembrane signaling receptor activity
DA391_RS03725	COG2197	response regulator
DA391_RS03750	COG2747	anti-sigma28 factor FlgM
DA391_RS03760	COG1815	bacterial-type flagellum-dependent cell motility
DA391_RS03770	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
DA391_RS03810	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DA391_RS03815	COG1191	sigma factor activity
DA391_RS03840	COG0643	Histidine kinase
DA391_RS03840	COG2198	Histidine kinase
DA391_RS03845	COG0835	chemotaxis
DA391_RS03895	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DA391_RS03905	COG0745	RESPONSE REGULATOR receiver
DA391_RS03915	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
DA391_RS03920	COG1677	Flagellar hook-basal body complex protein FliE
DA391_RS03925	COG1766	The M ring may be actively involved in energy transduction
DA391_RS03935	COG1317	bacterial-type flagellum organization
DA391_RS03940	COG1157	protein secretion by the type III secretion system
DA391_RS03950	COG3144	bacterial-type flagellum assembly
DA391_RS03955	COG1580	Controls the rotational direction of flagella during chemotaxis
DA391_RS03965	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DA391_RS03980	COG1987	bacterial-type flagellum assembly
DA391_RS03995	COG0745	RESPONSE REGULATOR receiver
DA391_RS04025	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DA391_RS04040	COG0673	inositol 2-dehydrogenase activity
DA391_RS04045	COG0823	Involved in the tonB-independent uptake of proteins
DA391_RS04050	COG1653	transport
DA391_RS04055	COG1082	Xylose isomerase domain protein TIM barrel
DA391_RS04060	COG0626	cystathionine gamma-synthase activity
DA391_RS04065	COG0814	amino acid
DA391_RS04070	COG0583	DNA-binding transcription factor activity
DA391_RS04085	COG3655	Transcriptional regulator
DA391_RS04100	COG3121	Chaperone
DA391_RS04105	COG3188	usher protein
DA391_RS04120	COG2197	response regulator
DA391_RS04145	COG1982	Orn Lys Arg decarboxylase major
DA391_RS04150	COG0741	lytic transglycosylase activity
DA391_RS04160	COG1194	a g-specific adenine glycosylase
DA391_RS04165	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DA391_RS04170	COG3171	Protein conserved in bacteria
DA391_RS04185	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DA391_RS04195	COG1872	DUF167
DA391_RS04200	COG0762	integral membrane protein
DA391_RS04205	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DA391_RS04210	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
DA391_RS04215	COG2805	Type II/IV secretion system protein
DA391_RS04225	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DA391_RS04230	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DA391_RS04235	COG1678	Uncharacterized ACR, COG1678
DA391_RS04240	COG0189	ligase activity
DA391_RS04245	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DA391_RS04250	COG2356	endonuclease I
DA391_RS04255	COG3091	SprT-like family
DA391_RS04260	COG0640	Transcriptional regulator
DA391_RS04275	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DA391_RS04280	COG1166	arginine decarboxylase activity
DA391_RS04290	COG0501	Belongs to the peptidase M48B family
DA391_RS04295	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
DA391_RS04300	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DA391_RS04305	COG0126	phosphoglycerate kinase activity
DA391_RS04310	COG0191	fructose-bisphosphate aldolase activity
DA391_RS04325	COG1279	arginine transmembrane transporter activity
DA391_RS04335	COG0583	DNA-binding transcription factor activity
DA391_RS04340	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
DA391_RS04345	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DA391_RS04350	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DA391_RS04360	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
DA391_RS04365	COG3079	Belongs to the UPF0149 family
DA391_RS04370	COG0006	proline dipeptidase activity
DA391_RS04375	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DA391_RS04380	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DA391_RS04385	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DA391_RS04390	COG0509	glycine decarboxylation via glycine cleavage system
DA391_RS04395	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DA391_RS04395	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DA391_RS04400	COG1028	Short-chain dehydrogenase reductase Sdr
DA391_RS04405	COG1272	protein, Hemolysin III
DA391_RS04410	COG0354	folic acid binding
DA391_RS04425	COG0745	RESPONSE REGULATOR receiver
DA391_RS04430	COG2205	protein histidine kinase activity
DA391_RS04435	COG4452	Inner membrane protein CreD
DA391_RS04440	COG0716	FMN binding
DA391_RS04445	COG4974	Belongs to the 'phage' integrase family
DA391_RS04450	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DA391_RS04455	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
DA391_RS04480	COG0656	L-ascorbic acid biosynthetic process
DA391_RS04500	COG3706	GGDEF domain
DA391_RS04505	COG1522	sequence-specific DNA binding
DA391_RS04520	COG2271	Major facilitator Superfamily
DA391_RS04530	COG0484	heat shock protein binding
DA391_RS04540	COG1028	Short-chain dehydrogenase reductase Sdr
DA391_RS04545	COG1733	regulation of RNA biosynthetic process
DA391_RS04585	COG0583	DNA-binding transcription factor activity
DA391_RS04590	COG2814	Major facilitator Superfamily
DA391_RS04595	COG0583	DNA-binding transcription factor activity
DA391_RS04610	COG1609	Transcriptional regulator
DA391_RS04620	COG0318	PFAM AMP-dependent synthetase and ligase
DA391_RS04620	COG0204	Acyl-transferase
DA391_RS04625	COG0477	Major facilitator Superfamily
DA391_RS04630	COG5499	transcription regulator containing HTH domain
DA391_RS04635	COG0667	Aldo Keto reductase
DA391_RS04640	COG0861	Integral membrane protein TerC family
DA391_RS04645	COG3066	DNA modification
DA391_RS04655	COG1051	belongs to the nudix hydrolase family
DA391_RS04665	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DA391_RS04675	COG2165	general secretion pathway protein
DA391_RS04695	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
DA391_RS04700	COG1025	Belongs to the peptidase M16 family
DA391_RS04705	COG1074	ATP-dependent DNA helicase activity
DA391_RS04710	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DA391_RS04715	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DA391_RS04715	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
DA391_RS04720	COG0860	N-Acetylmuramoyl-L-alanine amidase
DA391_RS04740	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
DA391_RS04745	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
DA391_RS04750	COG2166	iron-sulfur cluster assembly
DA391_RS04755	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DA391_RS04765	COG0583	DNA-binding transcription factor activity
DA391_RS04770	COG2363	Small membrane protein
DA391_RS04775	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
DA391_RS04785	COG1611	Belongs to the LOG family
DA391_RS04790	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
DA391_RS04790	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
DA391_RS04800	COG3098	single-species biofilm formation
DA391_RS04805	COG0564	pseudouridine synthase activity
DA391_RS04825	COG2171	N-acyltransferase activity
DA391_RS04830	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
DA391_RS04850	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DA391_RS04855	COG0528	UMP kinase activity
DA391_RS04865	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
DA391_RS04875	COG0575	Belongs to the CDS family
DA391_RS04880	COG0750	zinc metalloprotease
DA391_RS04890	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
DA391_RS04895	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DA391_RS04905	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DA391_RS04915	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DA391_RS04920	COG0587	DNA-directed DNA polymerase activity
DA391_RS04925	COG0825	malonyl-CoA metabolic process
DA391_RS04930	COG0346	lactoylglutathione lyase activity
DA391_RS04945	COG4568	rho-dependent transcription termination
DA391_RS04955	COG4681	YaeQ
DA391_RS04965	COG3015	lipoprotein NlpE involved in copper resistance
DA391_RS04970	COG0442	prolyl-tRNA aminoacylation
DA391_RS04975	COG1720	tRNA m6t6A37 methyltransferase activity
DA391_RS04985	COG1464	Belongs to the NlpA lipoprotein family
DA391_RS04990	COG2011	ABC-type metal ion transport system permease component
DA391_RS05000	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
DA391_RS05040	COG0583	DNA-binding transcription factor activity
DA391_RS05045	COG0656	L-ascorbic acid biosynthetic process
DA391_RS05050	COG3021	interspecies interaction between organisms
DA391_RS05055	COG1388	LysM domain
DA391_RS05055	COG0741	lytic transglycosylase activity
DA391_RS05060	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DA391_RS05065	COG2226	methyltransferase
DA391_RS05075	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DA391_RS05085	COG2113	Glycine betaine
DA391_RS05090	COG4176	ABC-type proline glycine betaine transport system permease component
DA391_RS05100	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DA391_RS05110	COG1780	Probably involved in ribonucleotide reductase function
DA391_RS05120	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DA391_RS05130	COG4575	ribosome binding
DA391_RS05155	COG0747	negative chemotaxis
DA391_RS05165	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DA391_RS05170	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
DA391_RS05185	COG0831	urea catabolic process
DA391_RS05190	COG0832	Belongs to the urease beta subunit family
DA391_RS05195	COG0804	urea catabolic process
DA391_RS05200	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
DA391_RS05210	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
DA391_RS05220	COG4413	Urea transporter
DA391_RS05225	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
DA391_RS05235	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DA391_RS05250	COG2133	pyrroloquinoline quinone binding
DA391_RS05255	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DA391_RS05260	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DA391_RS05265	COG1447	Phosphotransferase system cellobiose-specific component IIA
DA391_RS05270	COG1917	Cupin 2, conserved barrel domain protein
DA391_RS05270	COG2169	Transcriptional regulator
DA391_RS05275	COG3394	polysaccharide catabolic process
DA391_RS05285	COG1595	DNA-templated transcription, initiation
DA391_RS05290	COG3712	iron ion homeostasis
DA391_RS05295	COG4772	TonB-dependent receptor
DA391_RS05300	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
DA391_RS05305	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DA391_RS05310	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DA391_RS05315	COG1120	ATPase activity
DA391_RS05330	COG0789	Transcriptional regulator
DA391_RS05345	COG0251	oxidation-reduction process
DA391_RS05350	COG0563	adenylate kinase activity
DA391_RS05365	COG1401	restriction endodeoxyribonuclease activity
DA391_RS05415	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
DA391_RS05420	COG2867	negative regulation of translational initiation
DA391_RS05430	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DA391_RS05435	COG0497	DNA recombination
DA391_RS05440	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DA391_RS05445	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DA391_RS05450	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
DA391_RS05460	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
DA391_RS05465	COG0513	Belongs to the DEAD box helicase family
DA391_RS05470	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
DA391_RS05475	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
DA391_RS05490	COG3026	antisigma factor binding
DA391_RS05495	COG3086	response to oxidative stress
DA391_RS05525	COG1381	Involved in DNA repair and RecF pathway recombination
DA391_RS05530	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
DA391_RS05535	COG0736	holo-[acyl-carrier-protein] synthase activity
DA391_RS05540	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
DA391_RS05545	COG1737	Transcriptional regulator
DA391_RS05550	COG0560	Phosphoserine phosphatase
DA391_RS05560	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
DA391_RS05575	COG2205	protein histidine kinase activity
DA391_RS05580	COG3170	Tfp pilus assembly protein FimV
DA391_RS05585	COG2204	response regulator
DA391_RS05590	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DA391_RS05590	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DA391_RS05595	COG0347	Belongs to the P(II) protein family
DA391_RS05610	COG1735	metal-dependent hydrolase with the TIM-barrel fold
DA391_RS05615	COG3457	Alanine racemase
DA391_RS05625	COG2188	Transcriptional regulator
DA391_RS05630	COG1017	nitric oxide dioxygenase activity
DA391_RS05630	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DA391_RS05645	COG2814	Major facilitator Superfamily
DA391_RS05650	COG3711	transcriptional antiterminator
DA391_RS05655	COG3683	transport system, periplasmic component
DA391_RS05660	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
DA391_RS05665	COG0483	inositol monophosphate 1-phosphatase activity
DA391_RS05670	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
DA391_RS05675	COG1959	2 iron, 2 sulfur cluster binding
DA391_RS05685	COG0822	iron-sulfur transferase activity
DA391_RS05695	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
DA391_RS05700	COG0443	Heat shock 70 kDa protein
DA391_RS05705	COG0633	Ferredoxin
DA391_RS05710	COG2975	iron-sulfur cluster assembly
DA391_RS05725	COG3468	outer membrane autotransporter barrel domain protein
DA391_RS05730	COG2373	Large extracellular alpha-helical protein
DA391_RS05735	COG4953	penicillin-binding protein 1C
DA391_RS05760	COG1426	Protein conserved in bacteria
DA391_RS05775	COG2976	Protein conserved in bacteria
DA391_RS05780	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DA391_RS05785	COG1160	GTP binding
DA391_RS05795	COG1645	bacterial-type flagellum-dependent swarming motility
DA391_RS05800	COG1570	exodeoxyribonuclease VII activity
DA391_RS05805	COG0516	GMP reductase activity
DA391_RS05805	COG0517	IMP dehydrogenase activity
DA391_RS05810	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DA391_RS05810	COG0519	Catalyzes the synthesis of GMP from XMP
DA391_RS05820	COG3710	Transcriptional regulator
DA391_RS05830	COG2197	response regulator
DA391_RS05845	COG3121	Chaperone
DA391_RS05855	COG3121	Chaperone
DA391_RS05860	COG3121	Chaperone
DA391_RS05875	COG0351	phosphomethylpyrimidine kinase
DA391_RS05895	COG1349	DNA-binding transcription factor activity
DA391_RS05900	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
DA391_RS05905	COG1028	Short-chain dehydrogenase reductase Sdr
DA391_RS05920	COG3730	PTS system glucitol sorbitol-specific
DA391_RS05925	COG1597	lipid kinase activity
DA391_RS05930	COG0826	peptidase U32
DA391_RS05935	COG3422	double-strand break repair
DA391_RS05940	COG0745	RESPONSE REGULATOR receiver
DA391_RS05945	COG2205	protein histidine kinase activity
DA391_RS05950	COG0477	Major facilitator Superfamily
DA391_RS05955	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DA391_RS05965	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DA391_RS05990	COG0443	Heat shock 70 kDa protein
DA391_RS05995	COG5002	protein histidine kinase activity
DA391_RS05995	COG5001	Diguanylate cyclase
DA391_RS05995	COG3447	MASE1 domain protein
DA391_RS06000	COG2239	Acts as a magnesium transporter
DA391_RS06015	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
DA391_RS06025	COG0581	inorganic phosphate transmembrane transporter activity
DA391_RS06035	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DA391_RS06040	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DA391_RS06055	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
DA391_RS06060	COG2233	PERMEase
DA391_RS06065	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DA391_RS06070	COG1393	Belongs to the ArsC family
DA391_RS06075	COG4783	chaperone-mediated protein folding
DA391_RS06080	COG0628	permease
DA391_RS06085	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DA391_RS06090	COG2716	regulation of RNA biosynthetic process
DA391_RS06095	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DA391_RS06100	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
DA391_RS06105	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DA391_RS06110	COG2321	neutral zinc metallopeptidase
DA391_RS06115	COG2707	UPF0756 membrane protein
DA391_RS06120	COG1444	tRNA N-acetyltransferase activity
DA391_RS06125	COG0400	carboxylic ester hydrolase activity
DA391_RS06135	COG1876	peptidase activity
DA391_RS06140	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DA391_RS06145	COG1393	Belongs to the ArsC family
DA391_RS06150	COG0583	DNA-binding transcription factor activity
DA391_RS06155	COG2197	response regulator
DA391_RS06170	COG1175	transmembrane transport
DA391_RS06175	COG3842	ATPase activity
DA391_RS06185	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DA391_RS06195	COG2197	response regulator
DA391_RS06200	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
DA391_RS06200	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
DA391_RS06205	COG3062	negative regulation of establishment of protein localization
DA391_RS06210	COG0243	molybdopterin cofactor binding
DA391_RS06215	COG3043	anaerobic respiration
DA391_RS06220	COG3005	denitrification pathway
DA391_RS06225	COG0494	nUDIX hydrolase
DA391_RS06240	COG0408	coproporphyrinogen oxidase activity
DA391_RS06245	COG0456	acetyltransferase
DA391_RS06255	COG1129	ABC transporter
DA391_RS06260	COG1172	Belongs to the binding-protein-dependent transport system permease family
DA391_RS06285	COG1028	Short-chain dehydrogenase reductase Sdr
DA391_RS06290	COG3111	PFAM Bacterial OB fold (BOF) protein
DA391_RS06300	COG2837	iron assimilation
DA391_RS06305	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DA391_RS06320	COG2731	YhcH YjgK YiaL family protein
DA391_RS06330	COG1737	Transcriptional regulator
DA391_RS06345	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
DA391_RS06350	COG4208	sulfate ABC transporter
DA391_RS06385	COG1216	Glycosyl transferase, family 2
DA391_RS06415	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DA391_RS06420	COG0745	RESPONSE REGULATOR receiver
DA391_RS06425	COG2205	protein histidine kinase activity
DA391_RS06440	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DA391_RS06450	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
DA391_RS06460	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DA391_RS06465	COG3530	Putative quorum-sensing-regulated virulence factor
DA391_RS06495	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DA391_RS06530	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DA391_RS06540	COG1914	H( )-stimulated, divalent metal cation uptake system
DA391_RS06550	COG0667	Aldo Keto reductase
DA391_RS06555	COG3961	Belongs to the TPP enzyme family
DA391_RS06570	COG0837	glucose binding
DA391_RS06575	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
DA391_RS06585	COG2223	nitrite transmembrane transporter activity
DA391_RS06590	COG3279	Response regulator of the LytR AlgR family
DA391_RS06595	COG3275	phosphorelay sensor kinase activity
DA391_RS06610	COG0436	Aminotransferase
DA391_RS06615	COG3038	cytochrome b561
DA391_RS06625	COG1598	PFAM Uncharacterised protein family UPF0150
DA391_RS06645	COG0406	alpha-ribazole phosphatase activity
DA391_RS06675	COG3302	dmso reductase anchor subunit
DA391_RS06680	COG0437	4 iron, 4 sulfur cluster binding
DA391_RS06685	COG0243	molybdopterin cofactor binding
DA391_RS06700	COG2951	lytic endotransglycosylase activity
DA391_RS06705	COG0531	amino acid
DA391_RS06725	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
DA391_RS06730	COG1127	ABC transporter
DA391_RS06745	COG3038	cytochrome b561
DA391_RS06750	COG2353	YceI-like domain
DA391_RS06755	COG1609	Transcriptional regulator
DA391_RS06760	COG1263	PTS System
DA391_RS06760	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DA391_RS06765	COG2723	6-phospho-beta-galactosidase activity
DA391_RS06775	COG1695	Transcriptional regulator
DA391_RS06780	COG2824	Alkylphosphonate utilization operon protein PhnA
DA391_RS06785	COG2226	methyltransferase
DA391_RS06790	COG0076	glutamate decarboxylase activity
DA391_RS06795	COG0531	amino acid
DA391_RS06810	COG2095	MarC family integral membrane protein
DA391_RS06820	COG2205	protein histidine kinase activity
DA391_RS06820	COG0784	Response regulator, receiver
DA391_RS06820	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DA391_RS06820	COG2198	Histidine kinase
DA391_RS06825	COG2197	response regulator
DA391_RS06830	COG2181	nitrate reductase activity
DA391_RS06835	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
DA391_RS06840	COG1140	nitrate reductase beta subunit
DA391_RS06845	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
DA391_RS06850	COG2223	nitrite transmembrane transporter activity
DA391_RS06855	COG2197	response regulator
DA391_RS06860	COG3005	denitrification pathway
DA391_RS06865	COG0243	molybdopterin cofactor binding
DA391_RS06875	COG2116	formate transmembrane transporter activity
DA391_RS06885	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DA391_RS06890	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DA391_RS06895	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DA391_RS06900	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
DA391_RS06905	COG1138	Cytochrome C-type biogenesis protein
DA391_RS06910	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DA391_RS06915	COG3088	subunit of a heme lyase
DA391_RS06915	COG4235	cytochrome complex assembly
DA391_RS06920	COG4235	cytochrome complex assembly
DA391_RS06920	COG3088	subunit of a heme lyase
DA391_RS06945	COG3691	Protein conserved in bacteria
DA391_RS06950	COG0183	Belongs to the thiolase family
DA391_RS06955	COG1250	3-hydroxyacyl-CoA dehydrogenase
DA391_RS06955	COG1024	Enoyl-CoA hydratase
DA391_RS06965	COG2062	phosphohistidine phosphatase, SixA
DA391_RS06975	COG2840	Smr protein MutS2
DA391_RS06985	COG2890	protein-(glutamine-N5) methyltransferase activity
DA391_RS06995	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
DA391_RS07000	COG0730	response to heat
DA391_RS07005	COG3101	peptidyl-lysine hydroxylation
DA391_RS07015	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DA391_RS07015	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
DA391_RS07020	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DA391_RS07030	COG1794	racemase activity, acting on amino acids and derivatives
DA391_RS07040	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
DA391_RS07055	COG4232	protein-disulfide reductase activity
DA391_RS07065	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DA391_RS07070	COG1017	nitric oxide dioxygenase activity
DA391_RS07070	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DA391_RS07090	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
DA391_RS07100	COG0586	Pfam SNARE associated Golgi protein
DA391_RS07105	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
DA391_RS07110	COG0285	dihydrofolate synthase activity
DA391_RS07115	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
DA391_RS07120	COG1286	toxin biosynthetic process
DA391_RS07125	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
DA391_RS07140	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DA391_RS07145	COG4215	(ABC) transporter
DA391_RS07150	COG4160	amino acid transport
DA391_RS07155	COG4598	ABC transporter
DA391_RS07160	COG1090	epimerase
DA391_RS07170	COG0622	Phosphoesterase
DA391_RS07175	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
DA391_RS07180	COG0561	phosphatase activity
DA391_RS07185	COG2706	6-phosphogluconolactonase activity
DA391_RS07195	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
DA391_RS07200	COG0156	8-amino-7-oxononanoate synthase activity
DA391_RS07205	COG2226	methyltransferase
DA391_RS07220	COG0556	nucleotide-excision repair
DA391_RS07225	COG4628	conserved protein (DUF2132)
DA391_RS07230	COG0391	Required for morphogenesis under gluconeogenic growth conditions
DA391_RS07235	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DA391_RS07240	COG0315	cyclic pyranopterin monophosphate synthase activity
DA391_RS07245	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
DA391_RS07250	COG0314	molybdopterin synthase activity
DA391_RS07255	COG0670	Belongs to the BI1 family
DA391_RS07260	COG4774	siderophore transport
DA391_RS07275	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DA391_RS07285	COG4592	Periplasmic binding protein
DA391_RS07290	COG1169	isochorismate synthase
DA391_RS07295	COG1021	2,3-dihydroxybenzoate-AMP ligase
DA391_RS07300	COG3433	isochorismatase activity
DA391_RS07300	COG1535	isochorismatase
DA391_RS07305	COG1028	Short-chain dehydrogenase reductase Sdr
DA391_RS07310	COG0842	Transport permease protein
DA391_RS07315	COG0842	Transport permease protein
DA391_RS07320	COG1131	(ABC) transporter
DA391_RS07325	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DA391_RS07330	COG1309	transcriptional regulator
DA391_RS07335	COG0513	Belongs to the DEAD box helicase family
DA391_RS07340	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DA391_RS07350	COG1686	Belongs to the peptidase S11 family
DA391_RS07355	COG0277	FAD linked oxidase domain protein
DA391_RS07375	COG2261	transglycosylase associated protein
DA391_RS07385	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
DA391_RS07400	COG4807	Protein conserved in bacteria
DA391_RS07420	COG1122	ATPase activity
DA391_RS07430	COG2897	thiosulfate sulfurtransferase activity
DA391_RS07445	COG1732	Glycine betaine
DA391_RS07450	COG1174	glycine betaine transport
DA391_RS07455	COG1125	glycine betaine transport
DA391_RS07460	COG1174	glycine betaine transport
DA391_RS07470	COG0531	amino acid
DA391_RS07475	COG1982	Orn Lys Arg decarboxylase major
DA391_RS07485	COG0697	spore germination
DA391_RS07505	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DA391_RS07510	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DA391_RS07525	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DA391_RS07530	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
DA391_RS07540	COG1126	abc transporter atp-binding protein
DA391_RS07545	COG0765	amino acid transport
DA391_RS07550	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DA391_RS07555	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DA391_RS07560	COG0783	Belongs to the Dps family
DA391_RS07565	COG4106	trans-aconitate 2-methyltransferase activity
DA391_RS07580	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
DA391_RS07600	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
DA391_RS07620	COG0488	(ABC) transporter
DA391_RS07625	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DA391_RS07630	COG0303	'Molybdopterin
DA391_RS07640	COG0477	Major facilitator Superfamily
DA391_RS07655	COG0583	DNA-binding transcription factor activity
DA391_RS07660	COG0477	Major facilitator Superfamily
DA391_RS07665	COG0302	gtp cyclohydrolase
DA391_RS07670	COG2311	Membrane
DA391_RS07695	COG2116	formate transmembrane transporter activity
DA391_RS07700	COG3604	Transcriptional regulator
DA391_RS07705	COG3383	formate dehydrogenase (NAD+) activity
DA391_RS07710	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
DA391_RS07715	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
DA391_RS07725	COG3260	NADH ubiquinone oxidoreductase 20
DA391_RS07730	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DA391_RS07735	COG3261	NADH dehydrogenase
DA391_RS07735	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
DA391_RS07740	COG0651	ATP synthesis coupled electron transport
DA391_RS07745	COG4237	Hydrogenase 4 membrane
DA391_RS07750	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DA391_RS07755	COG0650	Formate hydrogenlyase subunit 4
DA391_RS07760	COG0651	ATP synthesis coupled electron transport
DA391_RS07765	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
DA391_RS07770	COG0375	protein maturation
DA391_RS07775	COG0298	carbon dioxide binding
DA391_RS07785	COG2949	membrane
DA391_RS07790	COG0281	malic enzyme
DA391_RS07800	COG1346	cytolysis
DA391_RS07805	COG1380	Effector of murein hydrolase LrgA
DA391_RS07810	COG2814	Major facilitator Superfamily
DA391_RS07825	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DA391_RS07825	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DA391_RS07830	COG0489	protein tyrosine kinase activity
DA391_RS07845	COG2982	Protein involved in outer membrane biogenesis
DA391_RS07850	COG3069	C4-dicarboxylate transmembrane transporter activity
DA391_RS07855	COG1253	flavin adenine dinucleotide binding
DA391_RS07880	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DA391_RS07890	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
DA391_RS07910	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DA391_RS07915	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DA391_RS07920	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
DA391_RS07925	COG0140	phosphoribosyl-ATP diphosphatase activity
DA391_RS07925	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
DA391_RS07930	COG0107	imidazoleglycerol-phosphate synthase activity
DA391_RS07935	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
DA391_RS07945	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
DA391_RS07945	COG0131	Imidazoleglycerol-phosphate dehydratase
DA391_RS07950	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DA391_RS07955	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DA391_RS07960	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DA391_RS07970	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DA391_RS07975	COG1172	Belongs to the binding-protein-dependent transport system permease family
DA391_RS07980	COG1129	ABC transporter
DA391_RS07985	COG0371	Dehydrogenase
DA391_RS07995	COG0531	amino acid
DA391_RS08000	COG2925	Exonuclease
DA391_RS08010	COG1289	transmembrane transporter activity
DA391_RS08015	COG2926	Belongs to the UPF0265 family
DA391_RS08025	COG1172	Belongs to the binding-protein-dependent transport system permease family
DA391_RS08030	COG1129	ABC transporter
DA391_RS08045	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DA391_RS08055	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
DA391_RS08075	COG4656	Part of a membrane complex involved in electron transport
DA391_RS08085	COG1012	belongs to the aldehyde dehydrogenase family
DA391_RS08095	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
DA391_RS08170	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
DA391_RS08180	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
DA391_RS08245	COG1492	cobalamin metabolic process
DA391_RS08265	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
DA391_RS08270	COG0583	DNA-binding transcription factor activity
DA391_RS08280	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
DA391_RS08285	COG2211	Major facilitator Superfamily
DA391_RS08290	COG0137	argininosuccinate synthase activity
DA391_RS08295	COG0534	Mate efflux family protein
DA391_RS08300	COG0835	chemotaxis
DA391_RS08300	COG0784	Response regulator, receiver
DA391_RS08305	COG4221	oxidoreductase activity
DA391_RS08310	COG3550	peptidyl-serine autophosphorylation
DA391_RS08315	COG3550	peptidyl-serine autophosphorylation
DA391_RS08355	COG1187	pseudouridine synthase activity
DA391_RS08360	COG3121	Chaperone
DA391_RS08375	COG3121	Chaperone
DA391_RS08385	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DA391_RS08385	COG2205	protein histidine kinase activity
DA391_RS08400	COG3842	ATPase activity
DA391_RS08410	COG1840	ABC-type Fe3 transport system, periplasmic component
DA391_RS08415	COG2271	Major facilitator Superfamily
DA391_RS08430	COG4565	transcriptional regulatory protein
DA391_RS08435	COG3290	protein histidine kinase activity
DA391_RS08440	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
DA391_RS08445	COG3052	prosthetic group binding
DA391_RS08450	COG2301	Belongs to the HpcH HpaI aldolase family
DA391_RS08455	COG3051	citrate lyase alpha subunit
DA391_RS08470	COG0471	metal ion transport
DA391_RS08490	COG0700	Nucleoside recognition
DA391_RS08495	COG3366	ferrous iron transmembrane transporter activity
DA391_RS08505	COG0471	metal ion transport
DA391_RS08510	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
DA391_RS08515	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DA391_RS08520	COG0583	DNA-binding transcription factor activity
DA391_RS08530	COG3122	Protein conserved in bacteria
DA391_RS08585	COG3615	Tellurite resistance protein tehB
DA391_RS08610	COG0583	DNA-binding transcription factor activity
DA391_RS08645	COG3228	Belongs to the MtfA family
DA391_RS08675	COG1028	Short-chain dehydrogenase reductase Sdr
DA391_RS08675	COG0604	alcohol dehydrogenase
DA391_RS08675	COG3321	synthase
DA391_RS08680	COG3250	beta-galactosidase activity
DA391_RS08685	COG1609	Transcriptional regulator
DA391_RS08700	COG0840	transmembrane signaling receptor activity
DA391_RS08705	COG1285	pathogenesis
DA391_RS08715	COG2130	NADP-dependent
DA391_RS08720	COG0589	response to stress
DA391_RS08745	COG0643	Histidine kinase
DA391_RS08745	COG2198	Histidine kinase
DA391_RS08750	COG0835	chemotaxis
DA391_RS08760	COG0840	transmembrane signaling receptor activity
DA391_RS08765	COG0840	transmembrane signaling receptor activity
DA391_RS08770	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
DA391_RS08780	COG0745	RESPONSE REGULATOR receiver
DA391_RS08785	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
DA391_RS08790	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DA391_RS08795	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DA391_RS08805	COG3418	PFAM FlgN family protein
DA391_RS08810	COG2747	anti-sigma28 factor FlgM
DA391_RS08820	COG1815	bacterial-type flagellum-dependent cell motility
DA391_RS08825	COG1558	bacterial-type flagellum-dependent cell motility
DA391_RS08830	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
DA391_RS08865	COG1256	bacterial-type flagellum assembly
DA391_RS08885	COG1338	Plays a role in the flagellum-specific transport system
DA391_RS08920	COG1157	protein secretion by the type III secretion system
DA391_RS08925	COG1317	bacterial-type flagellum organization
DA391_RS08940	COG1677	Flagellar hook-basal body complex protein FliE
DA391_RS08945	COG0582	viral genome integration into host DNA
DA391_RS09080	COG0305	Participates in initiation and elongation during chromosome replication
DA391_RS09150	COG3772	lysozyme
DA391_RS09180	COG5410	chromosome segregation
DA391_RS09330	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
DA391_RS09335	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
DA391_RS09370	COG1191	sigma factor activity
DA391_RS09380	COG2515	1-aminocyclopropane-1-carboxylate deaminase
DA391_RS09385	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DA391_RS09390	COG0765	amino acid transport
DA391_RS09395	COG1126	abc transporter atp-binding protein
DA391_RS09415	COG0506	proline dehydrogenase activity
DA391_RS09415	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
DA391_RS09415	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
DA391_RS09425	COG0672	)-iron permease
DA391_RS09430	COG2822	iron ion transport
DA391_RS09450	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
DA391_RS09455	COG2233	PERMEase
DA391_RS09460	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DA391_RS09465	COG0778	Nitroreductase
DA391_RS09470	COG2267	carboxylic ester hydrolase activity
DA391_RS09475	COG0251	oxidation-reduction process
DA391_RS09480	COG1335	isochorismatase
DA391_RS09485	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DA391_RS09495	COG1309	transcriptional regulator
DA391_RS09500	COG1113	amino acid transport
DA391_RS09515	COG2264	protein methyltransferase activity
DA391_RS09530	COG0366	Alpha amylase catalytic
DA391_RS09540	COG3136	membrane protein required for alginate biosynthesis
DA391_RS09550	COG2197	response regulator
DA391_RS09555	COG0322	excinuclease ABC activity
DA391_RS09560	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DA391_RS09590	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
DA391_RS09620	COG1802	Transcriptional regulator
DA391_RS09620	COG4626	Terminase
DA391_RS09625	COG4725	Belongs to the MT-A70-like family
DA391_RS09630	COG3645	SOS response
DA391_RS09630	COG3646	Phage regulatory protein
DA391_RS09635	COG1403	HNH endonuclease
DA391_RS09650	COG3179	chitinase
DA391_RS09695	COG4695	Portal protein
DA391_RS09825	COG3069	C4-dicarboxylate transmembrane transporter activity
DA391_RS09830	COG1737	Transcriptional regulator
DA391_RS09835	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DA391_RS09865	COG0840	transmembrane signaling receptor activity
DA391_RS09875	COG2873	o-acetylhomoserine
DA391_RS09880	COG0702	epimerase
DA391_RS09885	COG1733	regulation of RNA biosynthetic process
DA391_RS09895	COG0246	Mannitol dehydrogenase
DA391_RS09900	COG1063	alcohol dehydrogenase
DA391_RS09905	COG1802	Transcriptional regulator
DA391_RS09910	COG2271	Major facilitator Superfamily
DA391_RS09915	COG0697	spore germination
DA391_RS09940	COG5001	Diguanylate cyclase
DA391_RS09940	COG4251	negative regulation of phosphorylation
DA391_RS09940	COG3706	GGDEF domain
DA391_RS09940	COG2203	Gaf domain
DA391_RS09950	COG1132	(ABC) transporter
DA391_RS09965	COG2207	Transcriptional regulator
DA391_RS10000	COG1113	amino acid transport
DA391_RS10020	COG1496	oxidoreductase activity
DA391_RS10025	COG0768	penicillin binding
DA391_RS10040	COG5002	protein histidine kinase activity
DA391_RS10040	COG5001	Diguanylate cyclase
DA391_RS10040	COG3447	MASE1 domain protein
DA391_RS10055	COG1971	Probably functions as a manganese efflux pump
DA391_RS10065	COG3716	PTS system mannose fructose sorbose family IID component
DA391_RS10070	COG3715	PTS system
DA391_RS10075	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
DA391_RS10075	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DA391_RS10080	COG1253	flavin adenine dinucleotide binding
DA391_RS10090	COG1760	l-serine dehydratase
DA391_RS10095	COG0494	nUDIX hydrolase
DA391_RS10105	COG3140	Belongs to the UPF0181 family
DA391_RS10110	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
DA391_RS10115	COG0513	Belongs to the DEAD box helicase family
DA391_RS10120	COG3141	response to X-ray
DA391_RS10135	COG1770	oligopeptidase
DA391_RS10140	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DA391_RS10155	COG1528	Iron-storage protein
DA391_RS10160	COG2372	response to copper ion
DA391_RS10165	COG1276	copper resistance
DA391_RS10180	COG0346	lactoylglutathione lyase activity
DA391_RS10215	COG0625	glutathione transferase activity
DA391_RS10240	COG3706	GGDEF domain
DA391_RS10240	COG4251	negative regulation of phosphorylation
DA391_RS10240	COG2203	Gaf domain
DA391_RS10240	COG5001	Diguanylate cyclase
DA391_RS10275	COG2814	Major facilitator Superfamily
DA391_RS10285	COG3008	intermembrane lipid transfer
DA391_RS10290	COG2995	paraquat-inducible protein a
DA391_RS10295	COG1956	GAF domain-containing protein
DA391_RS10300	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
DA391_RS10305	COG0793	Belongs to the peptidase S41A family
DA391_RS10310	COG0501	Belongs to the peptidase M48B family
DA391_RS10315	COG2814	Major facilitator Superfamily
DA391_RS10320	COG0823	Involved in the tonB-independent uptake of proteins
DA391_RS10330	COG3023	N-Acetylmuramoyl-L-alanine amidase
DA391_RS10335	COG1823	symporter activity
DA391_RS10340	COG1988	membrane-bound metal-dependent
DA391_RS10345	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
DA391_RS10355	COG3842	ATPase activity
DA391_RS10360	COG0395	ABC-type sugar transport system, permease component
DA391_RS10365	COG1175	transmembrane transport
DA391_RS10375	COG1028	Short-chain dehydrogenase reductase Sdr
DA391_RS10380	COG1917	Cupin 2, conserved barrel domain protein
DA391_RS10385	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DA391_RS10395	COG3001	Fructosamine kinase
DA391_RS10400	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DA391_RS10405	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DA391_RS10410	COG1121	(ABC) transporter
DA391_RS10415	COG0803	Belongs to the bacterial solute-binding protein 9 family
DA391_RS10440	COG3623	hexulose-6-phosphate isomerase
DA391_RS10445	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
DA391_RS10450	COG1070	Carbohydrate kinase
DA391_RS10470	COG1172	Belongs to the binding-protein-dependent transport system permease family
DA391_RS10475	COG1129	ABC transporter
DA391_RS10480	COG1414	Transcriptional regulator
DA391_RS10485	COG1811	Na channel or pump
DA391_RS10490	COG4249	Peptidase C14 caspase catalytic subunit p20
DA391_RS10530	COG0776	regulation of translation
DA391_RS10535	COG2719	SpoVR family
DA391_RS10540	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DA391_RS10545	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DA391_RS10550	COG0642	Histidine kinase
DA391_RS10560	COG3111	PFAM Bacterial OB fold (BOF) protein
DA391_RS10565	COG2814	Major facilitator Superfamily
DA391_RS10570	COG2200	EAL domain
DA391_RS10570	COG2199	diguanylate cyclase activity
DA391_RS10570	COG2202	Pas domain
DA391_RS10580	COG0583	DNA-binding transcription factor activity
DA391_RS10590	COG2718	Belongs to the UPF0229 family
DA391_RS10595	COG2766	serine protein kinase
DA391_RS10605	COG3713	MltA-interacting MipA family protein
DA391_RS10635	COG3139	Protein of unknown function (DUF1315)
DA391_RS10640	COG1335	isochorismatase
DA391_RS10645	COG0252	asparaginase activity
DA391_RS10650	COG0616	signal peptide processing
DA391_RS10655	COG0778	Nitroreductase
DA391_RS10665	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DA391_RS10675	COG0494	nUDIX hydrolase
DA391_RS10680	COG0708	Exodeoxyribonuclease III
DA391_RS10685	COG0583	DNA-binding transcription factor activity
DA391_RS10705	COG0788	formyltetrahydrofolate deformylase activity
DA391_RS10710	COG3012	SEC-C Motif Domain Protein
DA391_RS10720	COG1752	Esterase of the alpha-beta hydrolase superfamily
DA391_RS10725	COG0745	RESPONSE REGULATOR receiver
DA391_RS10735	COG2916	Histone family protein nucleoid-structuring protein H-NS
DA391_RS10745	COG1454	alcohol dehydrogenase
DA391_RS10745	COG1012	belongs to the aldehyde dehydrogenase family
DA391_RS10750	COG2095	MarC family integral membrane protein
DA391_RS10755	COG4166	transmembrane transport
DA391_RS10770	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DA391_RS10775	COG0444	Belongs to the ABC transporter superfamily
DA391_RS10780	COG4608	Belongs to the ABC transporter superfamily
DA391_RS10785	COG3099	Belongs to the UPF0263 family
DA391_RS10790	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DA391_RS10800	COG2200	EAL domain
DA391_RS10810	COG2350	Protein conserved in bacteria
DA391_RS10815	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
DA391_RS10825	COG2917	probably involved in intracellular septation
DA391_RS10840	COG3047	cAMP biosynthetic process
DA391_RS10850	COG0159	tryptophan synthase activity
DA391_RS10855	COG0133	tryptophan synthase activity
DA391_RS10860	COG0134	indole-3-glycerol-phosphate synthase activity
DA391_RS10860	COG0135	phosphoribosylanthranilate isomerase activity
DA391_RS10870	COG0512	Glutamine amidotransferase of anthranilate synthase
DA391_RS10885	COG0613	PHP domain protein
DA391_RS10890	COG0009	L-threonylcarbamoyladenylate synthase
DA391_RS10900	COG2197	response regulator
DA391_RS10910	COG1187	pseudouridine synthase activity
DA391_RS10920	COG1028	Short-chain dehydrogenase reductase Sdr
DA391_RS10925	COG0616	signal peptide processing
DA391_RS10945	COG0583	DNA-binding transcription factor activity
DA391_RS10955	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
DA391_RS10965	COG0671	phosphoesterase, PA-phosphatase related
DA391_RS10970	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
DA391_RS10975	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
DA391_RS10990	COG0284	orotidine-5'-phosphate decarboxylase activity
DA391_RS10995	COG0023	Translation Initiation Factor
DA391_RS11005	COG0235	Class ii aldolase
DA391_RS11015	COG1349	DNA-binding transcription factor activity
DA391_RS11030	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DA391_RS11035	COG2879	small protein
DA391_RS11040	COG1966	Carbon starvation protein
DA391_RS11045	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
DA391_RS11050	COG0243	molybdopterin cofactor binding
DA391_RS11055	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DA391_RS11065	COG4659	FMN binding
DA391_RS11075	COG2207	Transcriptional regulator
DA391_RS11075	COG3708	Transcriptional regulator
DA391_RS11090	COG4657	Part of a membrane complex involved in electron transport
DA391_RS11100	COG2759	Belongs to the formate--tetrahydrofolate ligase family
DA391_RS11115	COG2274	protein secretion by the type I secretion system
DA391_RS11120	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DA391_RS11125	COG2160	L-arabinose isomerase activity
DA391_RS11135	COG1879	ABC-type sugar transport system periplasmic component
DA391_RS11140	COG1129	ABC transporter
DA391_RS11145	COG1172	Belongs to the binding-protein-dependent transport system permease family
DA391_RS11155	COG0673	inositol 2-dehydrogenase activity
DA391_RS11160	COG0385	Bile acid
DA391_RS11165	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DA391_RS11170	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
DA391_RS11175	COG1263	PTS System
DA391_RS11175	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DA391_RS11180	COG1609	Transcriptional regulator
DA391_RS11200	COG5339	Protein conserved in bacteria
DA391_RS11210	COG0114	fumarate hydratase activity
DA391_RS11225	COG2814	Major facilitator Superfamily
DA391_RS11230	COG0583	DNA-binding transcription factor activity
DA391_RS11235	COG1940	carbohydrate kinase activity
DA391_RS11240	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
DA391_RS11260	COG1742	UPF0060 membrane protein
DA391_RS11265	COG4221	oxidoreductase activity
DA391_RS11270	COG0477	Major facilitator Superfamily
DA391_RS11295	COG2211	Major facilitator Superfamily
DA391_RS11310	COG0625	glutathione transferase activity
DA391_RS11320	COG1522	sequence-specific DNA binding
DA391_RS11345	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DA391_RS11370	COG0076	glutamate decarboxylase activity
DA391_RS11375	COG0531	amino acid
DA391_RS11385	COG1011	Hydrolase
DA391_RS11410	COG1028	Short-chain dehydrogenase reductase Sdr
DA391_RS11420	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
DA391_RS11435	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DA391_RS11440	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DA391_RS11445	COG0589	response to stress
DA391_RS11450	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
DA391_RS11455	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
DA391_RS11470	COG0531	amino acid
DA391_RS11480	COG0745	RESPONSE REGULATOR receiver
DA391_RS11485	COG2205	protein histidine kinase activity
DA391_RS11490	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
DA391_RS11500	COG3591	Belongs to the peptidase S1B family
DA391_RS11510	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
DA391_RS11515	COG1643	Atp-dependent helicase
DA391_RS11520	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DA391_RS11525	COG0477	Major facilitator Superfamily
DA391_RS11535	COG3423	Transcriptional regulator
DA391_RS11545	COG0246	Mannitol dehydrogenase
DA391_RS11550	COG1070	Carbohydrate kinase
DA391_RS11560	COG3784	Protein of unknown function (DUF1318)
DA391_RS11570	COG2911	Protein conserved in bacteria
DA391_RS11575	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DA391_RS11580	COG3042	response to heat
DA391_RS11590	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DA391_RS11590	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
DA391_RS11590	COG1013	pyruvate-flavodoxin oxidoreductase activity
DA391_RS11590	COG0674	pyruvate-flavodoxin oxidoreductase activity
DA391_RS11595	COG2723	6-phospho-beta-galactosidase activity
DA391_RS11600	COG2190	(PTS) system
DA391_RS11600	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DA391_RS11600	COG1263	PTS System
DA391_RS11605	COG3711	transcriptional antiterminator
DA391_RS11610	COG0037	tRNA processing
DA391_RS11620	COG4166	transmembrane transport
DA391_RS11625	COG2866	Carboxypeptidase
DA391_RS11630	COG4948	Mandelate Racemase Muconate Lactonizing
DA391_RS11635	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
DA391_RS11645	COG5642	Protein of unknown function (DUF2384)
DA391_RS11650	COG5654	RES domain protein
DA391_RS11655	COG3768	UPF0283 membrane protein
DA391_RS11660	COG3106	COG3106 Predicted ATPase
DA391_RS11670	COG1983	PspC domain protein
DA391_RS11680	COG1842	Phage shock protein A
DA391_RS11685	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
DA391_RS11695	COG4166	transmembrane transport
DA391_RS11705	COG4171	peptide transport system, permease
DA391_RS11715	COG4172	Belongs to the ABC transporter superfamily
DA391_RS11725	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DA391_RS11725	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DA391_RS11730	COG3104	oligopeptide transport
DA391_RS11735	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DA391_RS11755	COG0625	glutathione transferase activity
DA391_RS11765	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DA391_RS11775	COG3895	Periplasmic Protein
DA391_RS11780	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
DA391_RS11785	COG3133	Outer membrane lipoprotein
DA391_RS11790	COG1846	Transcriptional regulator
DA391_RS11800	COG1566	PFAM secretion protein HlyD family protein
DA391_RS11810	COG4989	oxidoreductase activity
DA391_RS11815	COG3313	Fe-S protein
DA391_RS11820	COG2194	sulfuric ester hydrolase activity
DA391_RS11825	COG1309	transcriptional regulator
DA391_RS11830	COG1902	pentaerythritol trinitrate reductase activity
DA391_RS11835	COG0346	lactoylglutathione lyase activity
DA391_RS11840	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DA391_RS11845	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
DA391_RS11850	COG0791	NLP P60 protein
DA391_RS11865	COG1609	Transcriptional regulator
DA391_RS11870	COG0583	DNA-binding transcription factor activity
DA391_RS11875	COG2814	Major facilitator Superfamily
DA391_RS11880	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DA391_RS11885	COG0307	riboflavin synthase, alpha
DA391_RS11890	COG0534	Mate efflux family protein
DA391_RS11915	COG1376	ErfK ybiS ycfS ynhG family protein
DA391_RS11915	COG1388	LysM domain
DA391_RS11920	COG2166	iron-sulfur cluster assembly
DA391_RS11930	COG0719	Fe-S assembly protein
DA391_RS11935	COG0396	ATPase activity
DA391_RS11940	COG0719	Fe-S assembly protein
DA391_RS11945	COG0316	Belongs to the HesB IscA family
DA391_RS11955	COG2050	protein possibly involved in aromatic compounds catabolism
DA391_RS11960	COG0277	FAD linked oxidase domain protein
DA391_RS11960	COG0247	lactate metabolic process
DA391_RS11965	COG0628	permease
DA391_RS11975	COG0574	Belongs to the PEP-utilizing enzyme family
DA391_RS11975	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DA391_RS11980	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
DA391_RS11995	COG0095	Lipoate-protein ligase
DA391_RS12000	COG0791	NLP P60 protein
DA391_RS12005	COG2076	Multidrug Resistance protein
DA391_RS12015	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
DA391_RS12020	COG0726	polysaccharide deacetylase
DA391_RS12030	COG0463	Glycosyl transferase, family 2
DA391_RS12035	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DA391_RS12040	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
DA391_RS12045	COG0386	Belongs to the glutathione peroxidase family
DA391_RS12050	COG4139	cobalamin transport
DA391_RS12060	COG0791	NLP P60 protein
DA391_RS12065	COG2186	Transcriptional regulator
DA391_RS12075	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
DA391_RS12080	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
DA391_RS12090	COG2983	Belongs to the UPF0260 family
DA391_RS12095	COG0179	Fumarylacetoacetate (FAA) hydrolase
DA391_RS12100	COG3100	YcgL domain-containing protein
DA391_RS12105	COG0850	regulation of cytokinetic process
DA391_RS12110	COG2894	cell division
DA391_RS12115	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
DA391_RS12120	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
DA391_RS12125	COG0318	PFAM AMP-dependent synthetase and ligase
DA391_RS12130	COG3065	identical protein binding
DA391_RS12140	COG1199	ATP-dependent helicase activity
DA391_RS12145	COG0251	oxidation-reduction process
DA391_RS12150	COG2076	Multidrug Resistance protein
DA391_RS12155	COG2076	Multidrug Resistance protein
DA391_RS12160	COG3397	chitin binding
DA391_RS12165	COG0800	Aldolase
DA391_RS12170	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
DA391_RS12175	COG1737	Transcriptional regulator
DA391_RS12180	COG0469	pyruvate kinase activity
DA391_RS12185	COG1560	Kdo2-lipid A biosynthetic process
DA391_RS12190	COG0739	heme binding
DA391_RS12195	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
DA391_RS12200	COG1121	(ABC) transporter
DA391_RS12205	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DA391_RS12210	COG2255	four-way junction helicase activity
DA391_RS12215	COG0632	four-way junction helicase activity
DA391_RS12225	COG0217	transcriptional regulatory protein
DA391_RS12230	COG0494	nUDIX hydrolase
DA391_RS12235	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DA391_RS12240	COG1335	isochorismatase
DA391_RS12245	COG1801	Protein of unknown function DUF72
DA391_RS12250	COG3788	relative of glutathione S-transferase, MAPEG superfamily
DA391_RS12260	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DA391_RS12265	COG3142	Participates in the control of copper homeostasis
DA391_RS12270	COG3102	Protein conserved in bacteria
DA391_RS12280	COG0728	peptidoglycan biosynthetic process
DA391_RS12285	COG0673	inositol 2-dehydrogenase activity
DA391_RS12295	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DA391_RS12300	COG0477	Major facilitator Superfamily
DA391_RS12310	COG3381	protein complex oligomerization
DA391_RS12320	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DA391_RS12335	COG3706	GGDEF domain
DA391_RS12340	COG0659	secondary active sulfate transmembrane transporter activity
DA391_RS12360	COG2890	protein-(glutamine-N5) methyltransferase activity
DA391_RS12365	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DA391_RS12370	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
DA391_RS12375	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
DA391_RS12385	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DA391_RS12395	COG0193	aminoacyl-tRNA hydrolase activity
DA391_RS12405	COG0012	GTP binding
DA391_RS12410	COG0582	viral genome integration into host DNA
DA391_RS12455	COG4974	Belongs to the 'phage' integrase family
DA391_RS12460	COG2003	Belongs to the UPF0758 family
DA391_RS12480	COG3423	Transcriptional regulator
DA391_RS12545	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
DA391_RS12550	COG2831	hemolysin activation secretion protein
DA391_RS12555	COG3210	domain, Protein
DA391_RS12595	COG0786	glutamate:sodium symporter activity
DA391_RS12600	COG0288	reversible hydration of carbon dioxide
DA391_RS12605	COG1073	alpha beta
DA391_RS12630	COG0667	Aldo Keto reductase
DA391_RS12635	COG0318	PFAM AMP-dependent synthetase and ligase
DA391_RS12640	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
DA391_RS12645	COG0644	oxidoreductase
DA391_RS12650	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
DA391_RS12655	COG2086	electron transfer activity
DA391_RS12660	COG1917	Cupin 2, conserved barrel domain protein
DA391_RS12660	COG2207	Transcriptional regulator
DA391_RS12665	COG1960	acyl-CoA dehydrogenase activity
DA391_RS12670	COG4670	ketone body catabolic process
DA391_RS12685	COG2271	Major facilitator Superfamily
DA391_RS12690	COG0583	DNA-binding transcription factor activity
DA391_RS12695	COG0738	Major facilitator superfamily
DA391_RS12705	COG4942	peptidase
DA391_RS12715	COG3443	Belongs to the bacterial solute-binding protein 9 family
DA391_RS12720	COG4211	Belongs to the binding-protein-dependent transport system permease family
DA391_RS12725	COG1129	ABC transporter
DA391_RS12740	COG0402	S-adenosylhomocysteine deaminase activity
DA391_RS12750	COG1228	amidohydrolase
DA391_RS12765	COG2988	succinylglutamate desuccinylase activity
DA391_RS12770	COG3724	N-succinylarginine dihydrolase activity
DA391_RS12780	COG3138	arginine N-succinyltransferase
DA391_RS12785	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DA391_RS12790	COG3866	Pectate lyase
DA391_RS12795	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DA391_RS12800	COG1271	oxidase subunit
DA391_RS12805	COG1294	oxidase, subunit
DA391_RS12815	COG3850	Histidine kinase
DA391_RS12830	COG0387	Pfam Sodium calcium exchanger
DA391_RS12835	COG1702	phosphate starvation-inducible protein PhoH
DA391_RS12850	COG3658	cytochrome
DA391_RS12855	COG1215	transferase activity, transferring glycosyl groups
DA391_RS12860	COG0726	polysaccharide deacetylase
DA391_RS12860	COG1649	PFAM Uncharacterised BCR, COG1649
DA391_RS12865	COG0457	Tetratricopeptide repeat
DA391_RS12870	COG0006	proline dipeptidase activity
DA391_RS12900	COG0577	efflux transmembrane transporter activity
DA391_RS12900	COG1136	(ABC) transporter
DA391_RS12910	COG0577	efflux transmembrane transporter activity
DA391_RS12910	COG1136	(ABC) transporter
DA391_RS12925	COG0672	)-iron permease
DA391_RS12935	COG1447	Phosphotransferase system cellobiose-specific component IIA
DA391_RS12940	COG2723	6-phospho-beta-galactosidase activity
DA391_RS12945	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DA391_RS12945	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DA391_RS12950	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DA391_RS12955	COG1609	Transcriptional regulator
DA391_RS12970	COG2066	Belongs to the glutaminase family
DA391_RS12975	COG3290	protein histidine kinase activity
DA391_RS12980	COG4565	transcriptional regulatory protein
DA391_RS12985	COG3493	citrate carrier protein
DA391_RS12995	COG3189	MarR family transcriptional regulator
DA391_RS13005	COG2223	nitrite transmembrane transporter activity
DA391_RS13010	COG0561	phosphatase activity
DA391_RS13110	COG4386	tail sheath protein
DA391_RS13235	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DA391_RS13340	COG0582	viral genome integration into host DNA
DA391_RS13345	COG0538	isocitrate dehydrogenase activity
DA391_RS13350	COG1187	pseudouridine synthase activity
DA391_RS13360	COG0482	sulfurtransferase activity
DA391_RS13365	COG2915	High frequency lysogenization protein hflD homolog
DA391_RS13370	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DA391_RS13380	COG0745	RESPONSE REGULATOR receiver
DA391_RS13385	COG2205	protein histidine kinase activity
DA391_RS13390	COG2850	peptidyl-arginine hydroxylation
DA391_RS13405	COG1940	carbohydrate kinase activity
DA391_RS13410	COG4591	ABC-type transport system involved in lipoprotein release permease component
DA391_RS13420	COG4591	ABC-type transport system involved in lipoprotein release permease component
DA391_RS13425	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
DA391_RS13430	COG3134	Outer membrane lipoprotein
DA391_RS13440	COG1252	NADH dehydrogenase
DA391_RS13445	COG3150	esterase
DA391_RS13460	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
DA391_RS13465	COG5633	Lipoprotein
DA391_RS13470	COG0537	adenosine 5'-monophosphoramidase activity
DA391_RS13475	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DA391_RS13485	COG1263	PTS System
DA391_RS13485	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DA391_RS13490	COG0084	hydrolase, TatD family'
DA391_RS13495	COG0470	DNA polymerase III
DA391_RS13500	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DA391_RS13505	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DA391_RS13510	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DA391_RS13515	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DA391_RS13540	COG0416	fatty acid biosynthetic process
DA391_RS13545	COG0333	Belongs to the bacterial ribosomal protein bL32 family
DA391_RS13550	COG1399	metal-binding, possibly nucleic acid-binding protein
DA391_RS13560	COG0564	pseudouridine synthase activity
DA391_RS13570	COG1530	ribonuclease E activity
DA391_RS13575	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
DA391_RS13580	COG0418	dihydroorotase activity
DA391_RS13600	COG2197	response regulator
DA391_RS13610	COG0628	permease
DA391_RS13620	COG0697	spore germination
DA391_RS13655	COG1560	Kdo2-lipid A biosynthetic process
DA391_RS13660	COG2259	Doxx family
DA391_RS13665	COG2814	Major facilitator Superfamily
DA391_RS13680	COG5645	(Lipo)protein
DA391_RS13685	COG2943	transferase activity, transferring hexosyl groups
DA391_RS13690	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
DA391_RS13705	COG3263	regulation of cellular component size
DA391_RS13715	COG3916	Acyl-homoserine-lactone synthase
DA391_RS13720	COG2771	luxR family
DA391_RS13725	COG4235	cytochrome complex assembly
DA391_RS13725	COG3088	subunit of a heme lyase
DA391_RS13730	COG3088	subunit of a heme lyase
DA391_RS13735	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DA391_RS13740	COG1138	Cytochrome C-type biogenesis protein
DA391_RS13745	COG3301	Polysulphide reductase, NrfD
DA391_RS13750	COG0437	4 iron, 4 sulfur cluster binding
DA391_RS13755	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
DA391_RS13785	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
DA391_RS13790	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DA391_RS13795	COG1263	PTS System
DA391_RS13795	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DA391_RS13805	COG0698	ribose 5-phosphate isomerase
DA391_RS13810	COG1737	Transcriptional regulator
DA391_RS13815	COG1879	ABC-type sugar transport system periplasmic component
DA391_RS13820	COG1129	ABC transporter
DA391_RS13825	COG1172	Belongs to the binding-protein-dependent transport system permease family
DA391_RS13830	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DA391_RS13835	COG1940	carbohydrate kinase activity
DA391_RS13840	COG1349	DNA-binding transcription factor activity
DA391_RS13850	COG0738	Major facilitator superfamily
DA391_RS13885	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
DA391_RS13940	COG4386	tail sheath protein
DA391_RS14030	COG3772	lysozyme
DA391_RS14040	COG1598	PFAM Uncharacterised protein family UPF0150
DA391_RS14045	COG1724	mRNA binding
DA391_RS14120	COG0582	viral genome integration into host DNA
DA391_RS14130	COG2920	part of a sulfur-relay system
DA391_RS14135	COG1254	Belongs to the acylphosphatase family
DA391_RS14145	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DA391_RS14155	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DA391_RS14160	COG3785	DNA binding
DA391_RS14165	COG1832	CoA-binding protein
DA391_RS14175	COG1803	Methylglyoxal synthase
DA391_RS14180	COG0210	DNA helicase
DA391_RS14185	COG3304	Inner membrane component domain
DA391_RS14190	COG1289	transmembrane transporter activity
DA391_RS14195	COG3070	regulator of competence-specific genes
DA391_RS14200	COG5404	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
DA391_RS14210	COG3120	sequence-specific DNA binding
DA391_RS14215	COG1067	ATP-dependent peptidase activity
DA391_RS14220	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DA391_RS14230	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DA391_RS14235	COG3130	regulation of translation
DA391_RS14240	COG3009	Protein conserved in bacteria
DA391_RS14245	COG3008	intermembrane lipid transfer
DA391_RS14245	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
DA391_RS14250	COG2995	paraquat-inducible protein a
DA391_RS14255	COG0488	(ABC) transporter
DA391_RS14260	COG0116	Belongs to the methyltransferase superfamily
DA391_RS14260	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DA391_RS14265	COG3217	Mosc domain protein beta barrel domain protein
DA391_RS14265	COG0633	Ferredoxin
DA391_RS14275	COG0167	dihydroorotate dehydrogenase activity
DA391_RS14280	COG0308	aminopeptidase N
DA391_RS14285	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
DA391_RS14290	COG0017	Asparaginyl-tRNA synthetase
DA391_RS14300	COG1448	Aminotransferase
DA391_RS14305	COG2200	EAL domain
DA391_RS14310	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DA391_RS14315	COG3108	Peptidase M15
DA391_RS14320	COG2989	Protein conserved in bacteria
DA391_RS14335	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
DA391_RS14340	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DA391_RS14345	COG1434	Gram-negative-bacterium-type cell wall biogenesis
DA391_RS14350	COG3173	Aminoglycoside phosphotransferase
DA391_RS14360	COG2835	tetraacyldisaccharide 4'-kinase activity
DA391_RS14365	COG1278	Cold shock
DA391_RS14375	COG5383	Protein conserved in bacteria
DA391_RS14395	COG0776	regulation of translation
DA391_RS14400	COG0539	negative regulation of cytoplasmic translation
DA391_RS14410	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DA391_RS14420	COG2323	membrane
DA391_RS14425	COG0252	asparaginase activity
DA391_RS14430	COG1944	ATP diphosphatase activity
DA391_RS14435	COG2116	formate transmembrane transporter activity
DA391_RS14440	COG1882	Formate acetyltransferase
DA391_RS14445	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
DA391_RS14450	COG2814	Major facilitator Superfamily
DA391_RS14455	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DA391_RS14460	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DA391_RS14465	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
DA391_RS14470	COG1674	ftsk spoiiie
DA391_RS14470	COG3107	peptidoglycan biosynthetic process
DA391_RS14480	COG0492	ferredoxin-NADP+ reductase activity
DA391_RS14485	COG4988	ABC transporter
DA391_RS14490	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
DA391_RS14495	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
DA391_RS14500	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
DA391_RS14505	COG0542	response to heat
DA391_RS14510	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
DA391_RS14515	COG1278	Cold shock
DA391_RS14525	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DA391_RS14530	COG2990	Protein conserved in bacteria
DA391_RS14535	COG3593	DNA synthesis involved in DNA repair
DA391_RS14540	COG2431	L-lysine efflux transmembrane transporter activity
DA391_RS14545	COG1151	hydroxylamine reductase activity
DA391_RS14550	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DA391_RS14555	COG0028	Belongs to the TPP enzyme family
DA391_RS14565	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
DA391_RS14570	COG0702	epimerase
DA391_RS14575	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DA391_RS14585	COG1605	Chorismate mutase
DA391_RS14590	COG1126	abc transporter atp-binding protein
DA391_RS14595	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DA391_RS14600	COG4215	(ABC) transporter
DA391_RS14605	COG4160	amino acid transport
DA391_RS14610	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DA391_RS14625	COG1177	transmembrane transport
DA391_RS14630	COG1176	ABC-type spermidine putrescine transport system, permease component I
DA391_RS14635	COG3842	ATPase activity
DA391_RS14645	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
DA391_RS14665	COG0569	domain protein
DA391_RS14665	COG2985	domain, Protein
DA391_RS14680	COG5464	transposase or invertase
DA391_RS14690	COG0671	phosphoesterase, PA-phosphatase related
DA391_RS14695	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
DA391_RS14700	COG1349	DNA-binding transcription factor activity
DA391_RS14705	COG0814	amino acid
DA391_RS14710	COG1760	l-serine dehydratase
DA391_RS14715	COG1686	Belongs to the peptidase S11 family
DA391_RS14725	COG0626	cystathionine gamma-synthase activity
DA391_RS14740	COG2011	ABC-type metal ion transport system permease component
DA391_RS14765	COG0625	glutathione transferase activity
DA391_RS14770	COG4771	TonB-dependent receptor
DA391_RS14775	COG0833	amino acid
DA391_RS14780	COG0583	DNA-binding transcription factor activity
DA391_RS14790	COG2855	membrane
DA391_RS14795	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
DA391_RS14800	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DA391_RS14800	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DA391_RS14800	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
DA391_RS14805	COG1105	Belongs to the carbohydrate kinase PfkB family
DA391_RS14830	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DA391_RS14845	COG0246	Mannitol dehydrogenase
DA391_RS14850	COG2186	Transcriptional regulator
DA391_RS14860	COG0523	cobalamin synthesis protein
DA391_RS14865	COG0671	phosphoesterase, PA-phosphatase related
DA391_RS14870	COG0791	NLP P60 protein
DA391_RS14875	COG2200	EAL domain
DA391_RS14880	COG4166	transmembrane transport
DA391_RS14885	COG4174	ABC transporter (Permease)
DA391_RS14890	COG4239	(ABC) transporter, permease
DA391_RS14895	COG4172	Belongs to the ABC transporter superfamily
DA391_RS14905	COG2814	Major facilitator Superfamily
DA391_RS14910	COG1187	pseudouridine synthase activity
DA391_RS14915	COG1061	Type III restriction enzyme res subunit
DA391_RS14925	COG3081	Nucleoid-associated protein
DA391_RS14930	COG3082	Protein of unknown function (DUF1414)
DA391_RS14950	COG2755	lipolytic protein G-D-S-L family
DA391_RS14950	COG0657	acetylesterase activity
DA391_RS14955	COG3539	Fimbrial protein
DA391_RS14960	COG3539	Fimbrial protein
DA391_RS14970	COG3539	Fimbrial protein
DA391_RS14980	COG3121	Chaperone
DA391_RS14985	COG3539	Fimbrial protein
DA391_RS14990	COG2723	6-phospho-beta-galactosidase activity
DA391_RS14995	COG2190	(PTS) system
DA391_RS14995	COG1263	PTS System
DA391_RS14995	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DA391_RS15000	COG1737	Transcriptional regulator
DA391_RS15020	COG3121	Chaperone
DA391_RS15055	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DA391_RS15080	COG1132	(ABC) transporter
DA391_RS15095	COG2223	nitrite transmembrane transporter activity
DA391_RS15100	COG2198	Histidine kinase
DA391_RS15100	COG0642	Histidine kinase
DA391_RS15110	COG2205	protein histidine kinase activity
DA391_RS15110	COG0784	Response regulator, receiver
DA391_RS15125	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DA391_RS15135	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DA391_RS15140	COG4574	serine-type endopeptidase inhibitor activity
DA391_RS15150	COG0814	amino acid
DA391_RS15180	COG1441	menaquinone biosynthetic process
DA391_RS15185	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
DA391_RS15195	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
DA391_RS15200	COG1169	isochorismate synthase
DA391_RS15210	COG4575	ribosome binding
DA391_RS15215	COG0129	dihydroxy-acid dehydratase activity
DA391_RS15220	COG4702	Belongs to the UPF0303 family
DA391_RS15230	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DA391_RS15235	COG1609	Transcriptional regulator
DA391_RS15240	COG1028	Short-chain dehydrogenase reductase Sdr
DA391_RS15245	COG3265	gluconokinase activity
DA391_RS15250	COG2731	YhcH YjgK YiaL family protein
DA391_RS15270	COG1007	ATP synthesis coupled electron transport
DA391_RS15275	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DA391_RS15280	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DA391_RS15285	COG0713	ATP synthesis coupled electron transport
DA391_RS15290	COG0839	Belongs to the complex I subunit 6 family
DA391_RS15295	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DA391_RS15300	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
DA391_RS15305	COG1034	ATP synthesis coupled electron transport
DA391_RS15320	COG0649	NAD binding
DA391_RS15320	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DA391_RS15325	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DA391_RS15330	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DA391_RS15335	COG0583	DNA-binding transcription factor activity
DA391_RS15340	COG0436	Aminotransferase
DA391_RS15350	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
DA391_RS15355	COG0471	metal ion transport
DA391_RS15355	COG0490	domain, Protein
DA391_RS15365	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DA391_RS15370	COG3013	Belongs to the UPF0304 family
DA391_RS15375	COG3092	negative regulation of chromosome organization
DA391_RS15385	COG0857	belongs to the CobB CobQ family
DA391_RS15385	COG0280	phosphate acetyltransferase
DA391_RS15390	COG1609	Transcriptional regulator
DA391_RS15395	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DA391_RS15405	COG3037	sugar-specific permease SgaT UlaA
DA391_RS15415	COG4149	molybdate abc transporter
DA391_RS15420	COG0725	ABC transporter, periplasmic molybdate-binding protein
DA391_RS15430	COG3585	molybdate ion transport
DA391_RS15430	COG2005	Transcriptional regulator
DA391_RS15435	COG1119	ATPase activity
DA391_RS15445	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DA391_RS15450	COG1085	galactose-1-phosphate uridylyltransferase
DA391_RS15455	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
DA391_RS15460	COG2017	converts alpha-aldose to the beta-anomer
DA391_RS15470	COG0588	phosphoglycerate mutase activity
DA391_RS15475	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
DA391_RS15480	COG1230	cation diffusion facilitator family transporter
DA391_RS15490	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
DA391_RS15520	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
DA391_RS15525	COG2885	chlorophyll binding
DA391_RS15530	COG0823	Involved in the tonB-independent uptake of proteins
DA391_RS15535	COG3064	Membrane
DA391_RS15535	COG3064	Membrane
DA391_RS15540	COG0848	biopolymer transport protein
DA391_RS15545	COG0811	peptide transport
DA391_RS15550	COG0824	Thioesterase
DA391_RS15555	COG3790	cyd operon protein YbgE
DA391_RS15560	COG4890	Cyd operon protein YbgT
DA391_RS15565	COG1294	oxidase, subunit
DA391_RS15570	COG1271	oxidase subunit
DA391_RS15575	COG0737	Belongs to the 5'-nucleotidase family
DA391_RS15580	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
DA391_RS15590	COG0508	dehydrogenase complex catalyzes the overall conversion of
DA391_RS15595	COG0567	Dehydrogenase, E1 component
DA391_RS15600	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DA391_RS15605	COG1053	succinate dehydrogenase
DA391_RS15610	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
DA391_RS15640	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
DA391_RS15645	COG1984	allophanate hydrolase subunit 2
DA391_RS15650	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
DA391_RS15655	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
DA391_RS15660	COG5212	phosphodiesterase
DA391_RS15670	COG3272	Protein of unknown function (DUF1722)
DA391_RS15685	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
DA391_RS15690	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
DA391_RS15695	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
DA391_RS15700	COG2205	protein histidine kinase activity
DA391_RS15705	COG0745	RESPONSE REGULATOR receiver
DA391_RS15715	COG0033	Phosphoglucomutase
DA391_RS15720	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
DA391_RS15725	COG0596	Alpha beta hydrolase
DA391_RS15735	COG0840	transmembrane signaling receptor activity
DA391_RS15745	COG0735	belongs to the Fur family
DA391_RS15770	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DA391_RS15775	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DA391_RS15775	COG2190	(PTS) system
DA391_RS15775	COG1263	PTS System
DA391_RS15785	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
DA391_RS15790	COG1940	carbohydrate kinase activity
DA391_RS15790	COG1846	Transcriptional regulator
DA391_RS15795	COG0647	UMP catabolic process
DA391_RS15800	COG0367	asparagine synthase
DA391_RS15835	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DA391_RS15840	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DA391_RS15845	COG1702	phosphate starvation-inducible protein PhoH
DA391_RS15850	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
DA391_RS15855	COG4535	Mg2 and Co2 transporter CorC
DA391_RS15860	COG0815	Transfers the fatty acyl group on membrane lipoproteins
DA391_RS15870	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DA391_RS15875	COG0765	amino acid transport
DA391_RS15880	COG0765	amino acid transport
DA391_RS15885	COG1126	abc transporter atp-binding protein
DA391_RS15890	COG2888	peptidyl-tyrosine sulfation
DA391_RS15900	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
DA391_RS15905	COG1466	dna polymerase III delta subunit
DA391_RS15910	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DA391_RS15915	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
DA391_RS15915	COG0546	phosphoglycolate phosphatase activity
DA391_RS16045	COG3772	lysozyme
DA391_RS16120	COG0305	Participates in initiation and elongation during chromosome replication
DA391_RS16180	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DA391_RS16240	COG0582	viral genome integration into host DNA
DA391_RS16245	COG0799	negative regulation of ribosome biogenesis
DA391_RS16255	COG0768	penicillin binding
DA391_RS16260	COG0772	Belongs to the SEDS family
DA391_RS16265	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
DA391_RS16270	COG1686	Belongs to the peptidase S11 family
DA391_RS16275	COG2921	Belongs to the UPF0250 family
DA391_RS16280	COG0321	lipoyl(octanoyl) transferase activity
DA391_RS16285	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DA391_RS16290	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DA391_RS16295	COG3706	GGDEF domain
DA391_RS16310	COG1278	Cold shock
DA391_RS16315	COG2197	response regulator
DA391_RS16325	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
DA391_RS16340	COG5265	(ABC) transporter
DA391_RS16345	COG2850	peptidyl-arginine hydroxylation
DA391_RS16350	COG2188	Transcriptional regulator
DA391_RS16360	COG0471	metal ion transport
DA391_RS16370	COG2979	Protein of unknown function (DUF533)
DA391_RS16405	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DA391_RS16410	COG2313	pseudouridylate synthase activity
DA391_RS16415	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DA391_RS16435	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
DA391_RS16460	COG3064	Membrane
DA391_RS16480	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DA391_RS16485	COG2501	S4 domain
DA391_RS16505	COG3539	Fimbrial protein
DA391_RS16515	COG3121	Chaperone
DA391_RS16520	COG3188	usher protein
DA391_RS16545	COG0215	cysteine-tRNA ligase activity
DA391_RS16550	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DA391_RS16555	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DA391_RS16560	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
DA391_RS16565	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
DA391_RS16570	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
DA391_RS16575	COG4181	ATPase activity
DA391_RS16580	COG2755	lipolytic protein G-D-S-L family
DA391_RS16585	COG0300	oxidoreductase activity
DA391_RS16590	COG3118	belongs to the thioredoxin family
DA391_RS16595	COG0330	HflC and HflK could
DA391_RS16600	COG1585	Membrane protein implicated in regulation of membrane protease activity
DA391_RS16610	COG2217	Heavy metal translocating P-type atpase
DA391_RS16615	COG3735	TraB family
DA391_RS16620	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DA391_RS16625	COG0737	Belongs to the 5'-nucleotidase family
DA391_RS16630	COG2223	nitrite transmembrane transporter activity
DA391_RS16635	COG4651	solute:proton antiporter activity
DA391_RS16635	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DA391_RS16640	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DA391_RS16645	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
DA391_RS16660	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DA391_RS16690	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
DA391_RS16695	COG0563	adenylate kinase activity
DA391_RS16700	COG0326	Molecular chaperone. Has ATPase activity
DA391_RS16705	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DA391_RS16720	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DA391_RS16725	COG2832	Protein of unknown function (DUF454)
DA391_RS16740	COG3264	Mechanosensitive ion channel
DA391_RS16740	COG1196	nuclear chromosome segregation
DA391_RS16745	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
DA391_RS16750	COG1309	transcriptional regulator
DA391_RS16755	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DA391_RS16760	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DA391_RS16770	COG3457	Alanine racemase
DA391_RS16775	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
DA391_RS16780	COG0254	rRNA binding
DA391_RS16785	COG0257	Belongs to the bacterial ribosomal protein bL36 family
DA391_RS16790	COG0803	Belongs to the bacterial solute-binding protein 9 family
DA391_RS16795	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DA391_RS16800	COG1121	(ABC) transporter
DA391_RS16840	COG3695	enzyme binding
DA391_RS16845	COG3126	Type III secretion system lipoprotein chaperone (YscW)
DA391_RS16850	COG1946	Acyl-CoA thioesterase
DA391_RS16855	COG0004	ammonium transporteR
DA391_RS16860	COG0347	Belongs to the P(II) protein family
DA391_RS16865	COG1132	(ABC) transporter
DA391_RS16870	COG1132	(ABC) transporter
DA391_RS16875	COG1522	sequence-specific DNA binding
DA391_RS16885	COG0561	phosphatase activity
DA391_RS16890	COG4533	DNA binding
DA391_RS16895	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
DA391_RS16900	COG0824	Thioesterase
DA391_RS16905	COG1555	photosystem II stabilization
DA391_RS16910	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DA391_RS16915	COG0776	regulation of translation
DA391_RS16920	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DA391_RS16925	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
DA391_RS16930	COG0740	serine-type endopeptidase activity
DA391_RS16935	COG0544	peptidyl-prolyl cis-trans isomerase activity
DA391_RS16945	COG0271	Belongs to the BolA IbaG family
DA391_RS16950	COG3056	Lipoprotein
DA391_RS16955	COG2223	nitrite transmembrane transporter activity
DA391_RS16965	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DA391_RS16970	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DA391_RS16975	COG1845	cytochrome c oxidase, subunit III
DA391_RS16980	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
DA391_RS16985	COG0109	protoheme IX farnesyltransferase activity
DA391_RS16990	COG2814	Major facilitator Superfamily
DA391_RS16995	COG1666	GTP binding
DA391_RS17000	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DA391_RS17005	COG0693	protein deglycase activity
DA391_RS17010	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DA391_RS17010	COG0301	tRNA thio-modification
DA391_RS17020	COG0142	geranyltranstransferase activity
DA391_RS17025	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DA391_RS17030	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
DA391_RS17035	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
DA391_RS17050	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DA391_RS17050	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DA391_RS17055	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DA391_RS17065	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DA391_RS17070	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DA391_RS17075	COG1862	Preprotein translocase
DA391_RS17080	COG0343	queuine tRNA-ribosyltransferase activity
DA391_RS17095	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
DA391_RS17100	COG0450	alkyl hydroperoxide reductase
DA391_RS17115	COG0366	Alpha amylase catalytic
DA391_RS17135	COG5002	protein histidine kinase activity
DA391_RS17140	COG0745	RESPONSE REGULATOR receiver
DA391_RS17145	COG0420	3'-5' exonuclease activity
DA391_RS17150	COG0419	ATPase involved in DNA repair
DA391_RS17155	COG1940	carbohydrate kinase activity
DA391_RS17160	COG2974	May be involved in recombination
DA391_RS17165	COG3123	guanosine phosphorylase activity
DA391_RS17170	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DA391_RS17185	COG2226	methyltransferase
DA391_RS17200	COG3459	Glycosyltransferase 36 associated
DA391_RS17210	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
DA391_RS17215	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DA391_RS17225	COG1073	alpha beta
DA391_RS17235	COG2195	Cleaves the N-terminal amino acid of tripeptides
DA391_RS17240	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DA391_RS17250	COG2991	Protein conserved in bacteria
DA391_RS17255	COG1477	protein flavinylation
DA391_RS17260	COG2871	sodium ion transport
DA391_RS17265	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
DA391_RS17270	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
DA391_RS17275	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
DA391_RS17280	COG1805	sodium ion transport
DA391_RS17285	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
DA391_RS17290	COG3034	peptidoglycan biosynthetic process
DA391_RS17295	COG0121	glutamine amidotransferase
DA391_RS17305	COG1960	acyl-CoA dehydrogenase activity
DA391_RS17310	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
DA391_RS17325	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
DA391_RS17335	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
DA391_RS17345	COG0235	Class ii aldolase
DA391_RS17350	COG0436	Aminotransferase
DA391_RS17360	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DA391_RS17365	COG2814	Major facilitator Superfamily
DA391_RS17370	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
DA391_RS17380	COG1846	Transcriptional regulator
DA391_RS17385	COG1566	PFAM secretion protein HlyD family protein
DA391_RS17390	COG2814	Major facilitator Superfamily
DA391_RS17395	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DA391_RS17400	COG3118	belongs to the thioredoxin family
DA391_RS17405	COG3148	PFAM DTW domain containing protein
DA391_RS17410	COG1042	CoA-binding domain protein
DA391_RS17410	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DA391_RS17410	COG0045	succinate-CoA ligase (ADP-forming) activity
DA391_RS17415	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DA391_RS17455	COG0542	response to heat
DA391_RS17465	COG0564	pseudouridine synthase activity
DA391_RS17475	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DA391_RS17480	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
DA391_RS17490	COG0077	Prephenate dehydratase
DA391_RS17490	COG1605	Chorismate mutase
DA391_RS17495	COG1605	Chorismate mutase
DA391_RS17495	COG0287	Prephenate dehydrogenase
DA391_RS17500	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
DA391_RS17505	COG3279	Response regulator of the LytR AlgR family
DA391_RS17510	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
DA391_RS17515	COG3137	Salt-induced outer membrane protein
DA391_RS17520	COG0335	large ribosomal subunit rRNA binding
DA391_RS17530	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DA391_RS17545	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DA391_RS17550	COG4137	Cytochrome C assembly protein
DA391_RS17555	COG4536	flavin adenine dinucleotide binding
DA391_RS17560	COG1854	S-ribosylhomocysteine lyase activity
DA391_RS17565	COG2918	glutathione biosynthetic process
DA391_RS17570	COG1238	metal cluster binding
DA391_RS17575	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DA391_RS17600	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
DA391_RS17605	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DA391_RS17610	COG2137	regulation of response to DNA damage stimulus
DA391_RS17615	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
DA391_RS17640	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DA391_RS17645	COG3958	Transketolase
DA391_RS17650	COG3959	Transketolase, thiamine diphosphate binding domain
DA391_RS17655	COG1172	Belongs to the binding-protein-dependent transport system permease family
DA391_RS17660	COG1129	ABC transporter
DA391_RS17670	COG1879	ABC-type sugar transport system periplasmic component
DA391_RS17685	COG3381	protein complex oligomerization
DA391_RS17690	COG3302	dmso reductase anchor subunit
DA391_RS17695	COG0437	4 iron, 4 sulfur cluster binding
DA391_RS17700	COG0243	molybdopterin cofactor binding
DA391_RS17705	COG1454	alcohol dehydrogenase
DA391_RS17710	COG0235	Class ii aldolase
DA391_RS17715	COG0738	Major facilitator superfamily
DA391_RS17725	COG1070	Carbohydrate kinase
DA391_RS17735	COG1349	DNA-binding transcription factor activity
DA391_RS17745	COG1349	DNA-binding transcription factor activity
DA391_RS17755	COG1129	ABC transporter
DA391_RS17760	COG1172	Belongs to the binding-protein-dependent transport system permease family
DA391_RS17770	COG3623	hexulose-6-phosphate isomerase
DA391_RS17775	COG1070	Carbohydrate kinase
DA391_RS17780	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
DA391_RS17780	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
DA391_RS17795	COG4177	L-phenylalanine transmembrane transporter activity
DA391_RS17800	COG1137	ATPase activity
DA391_RS17805	COG0410	ABC transporter
DA391_RS17860	COG0640	Transcriptional regulator
DA391_RS17865	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DA391_RS17880	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DA391_RS17885	COG1126	abc transporter atp-binding protein
DA391_RS17890	COG0765	amino acid transport
DA391_RS17895	COG0765	amino acid transport
DA391_RS17900	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DA391_RS17905	COG3048	D-serine ammonia-lyase activity
DA391_RS17910	COG2610	gluconate transmembrane transporter activity
DA391_RS17915	COG0583	DNA-binding transcription factor activity
DA391_RS17925	COG4608	Belongs to the ABC transporter superfamily
DA391_RS17930	COG0444	Belongs to the ABC transporter superfamily
DA391_RS17935	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DA391_RS17940	COG0601	transmembrane transport
DA391_RS17945	COG0747	negative chemotaxis
DA391_RS17950	COG4948	Mandelate Racemase Muconate Lactonizing
DA391_RS17955	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DA391_RS17970	COG1028	Short-chain dehydrogenase reductase Sdr
DA391_RS17990	COG1538	Outer membrane efflux protein
DA391_RS17995	COG1136	(ABC) transporter
DA391_RS17995	COG0577	efflux transmembrane transporter activity
DA391_RS18000	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DA391_RS18030	COG3539	Fimbrial protein
DA391_RS18035	COG3539	Fimbrial protein
DA391_RS18050	COG3121	Chaperone
DA391_RS18055	COG3188	usher protein
DA391_RS18080	COG3876	Protein conserved in bacteria
DA391_RS18090	COG1472	Belongs to the glycosyl hydrolase 3 family
DA391_RS18100	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
DA391_RS18105	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DA391_RS18105	COG1263	PTS System
DA391_RS18120	COG3121	Chaperone
DA391_RS18125	COG3121	Chaperone
DA391_RS18135	COG3121	Chaperone
DA391_RS18150	COG0626	cystathionine gamma-synthase activity
DA391_RS18165	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
DA391_RS18170	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DA391_RS18175	COG4942	peptidase
DA391_RS18175	COG1388	LysM domain
DA391_RS18180	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DA391_RS18185	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
DA391_RS18190	COG0585	pseudouridine synthase activity
DA391_RS18195	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
DA391_RS18205	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
DA391_RS18220	COG0765	amino acid transport
DA391_RS18235	COG0529	Catalyzes the synthesis of activated sulfate
DA391_RS18240	COG2895	sulfate adenylyltransferase (ATP) activity
DA391_RS18245	COG0175	sulfate reduction
DA391_RS18250	COG1648	precorrin-2 dehydrogenase activity
DA391_RS18250	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DA391_RS18255	COG2234	aminopeptidase activity
DA391_RS18260	COG0175	sulfate reduction
DA391_RS18265	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DA391_RS18270	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DA391_RS18275	COG0720	synthase
DA391_RS18280	COG0602	queuosine metabolic process
DA391_RS18295	COG0504	CTP synthase activity
DA391_RS18300	COG3956	TIGRFAM MazG family protein
DA391_RS18305	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DA391_RS18310	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DA391_RS18320	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DA391_RS18325	COG0232	Belongs to the dGTPase family. Type 2 subfamily
DA391_RS18330	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DA391_RS18340	COG2860	membrane
DA391_RS18355	COG0316	Belongs to the HesB IscA family
DA391_RS18365	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DA391_RS18370	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DA391_RS18375	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DA391_RS18380	COG1120	ATPase activity
DA391_RS18385	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DA391_RS18390	COG1643	Atp-dependent helicase
DA391_RS18395	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
DA391_RS18420	COG0617	tRNA 3'-terminal CCA addition
DA391_RS18425	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DA391_RS18430	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
DA391_RS18435	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
DA391_RS18440	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
DA391_RS18445	COG0726	polysaccharide deacetylase
DA391_RS18450	COG0842	Transport permease protein
DA391_RS18455	COG1131	(ABC) transporter
DA391_RS18460	COG0288	reversible hydration of carbon dioxide
DA391_RS18465	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
DA391_RS18475	COG2132	Multicopper oxidase
DA391_RS18485	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
DA391_RS18500	COG3112	Uncharacterised protein family (UPF0231)
DA391_RS18520	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DA391_RS18525	COG0508	dehydrogenase complex catalyzes the overall conversion of
DA391_RS18530	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
DA391_RS18535	COG2186	Transcriptional regulator
DA391_RS18540	COG1113	amino acid transport
DA391_RS18550	COG3725	Membrane protein required for beta-lactamase induction
DA391_RS18555	COG3023	N-Acetylmuramoyl-L-alanine amidase
DA391_RS18565	COG4969	Belongs to the N-Me-Phe pilin family
DA391_RS18570	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DA391_RS18575	COG1459	type II secretion system
DA391_RS18580	COG0516	GMP reductase activity
DA391_RS18600	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
DA391_RS18605	COG0494	nUDIX hydrolase
DA391_RS18610	COG0653	protein targeting
DA391_RS18630	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
DA391_RS18635	COG0849	cell division
DA391_RS18640	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
DA391_RS18650	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DA391_RS18655	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DA391_RS18660	COG0772	Belongs to the SEDS family
DA391_RS18670	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DA391_RS18675	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DA391_RS18680	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DA391_RS18685	COG0768	penicillin binding
DA391_RS18690	COG3116	cell division
DA391_RS18695	COG0275	rRNA processing
DA391_RS18720	COG0028	Belongs to the TPP enzyme family
DA391_RS18725	COG1022	Amp-dependent synthetase and ligase
DA391_RS18745	COG0473	3-isopropylmalate dehydrogenase activity
DA391_RS18750	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DA391_RS18765	COG3033	Beta-eliminating lyase
DA391_RS18770	COG0814	amino acid
DA391_RS18775	COG2814	Major facilitator Superfamily
DA391_RS18780	COG1882	Formate acetyltransferase
DA391_RS18785	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
DA391_RS18790	COG4533	DNA binding
DA391_RS18795	COG4143	(ABC) transporter
DA391_RS18800	COG1178	ABC-type Fe3 transport system permease component
DA391_RS18805	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
DA391_RS18810	COG0586	Pfam SNARE associated Golgi protein
DA391_RS18815	COG0417	DNA replication proofreading
DA391_RS18825	COG2375	cellular response to nickel ion
DA391_RS18860	COG0564	pseudouridine synthase activity
DA391_RS18870	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
DA391_RS18875	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
DA391_RS18890	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DA391_RS18895	COG2967	ApaG domain
DA391_RS18900	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
DA391_RS18905	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
DA391_RS18915	COG2966	Psort location CytoplasmicMembrane, score
DA391_RS18920	COG1280	lysine exporter protein (LysE YggA)
DA391_RS18925	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DA391_RS18940	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
DA391_RS18945	COG1047	Peptidyl-prolyl cis-trans
DA391_RS18955	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DA391_RS18960	COG0196	riboflavin kinase activity
DA391_RS18980	COG0583	DNA-binding transcription factor activity
DA391_RS18985	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
DA391_RS18995	COG0484	heat shock protein binding
DA391_RS19005	COG1584	GPR1 FUN34 yaaH family protein
DA391_RS19020	COG0521	Mo-molybdopterin cofactor biosynthetic process
DA391_RS19025	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DA391_RS19035	COG3022	response to hydroperoxide
DA391_RS19045	COG0083	homoserine kinase activity
DA391_RS19060	COG0745	RESPONSE REGULATOR receiver
DA391_RS19065	COG3045	CreA protein
DA391_RS19075	COG2207	Transcriptional regulator
DA391_RS19075	COG3708	Transcriptional regulator
DA391_RS19080	COG0406	alpha-ribazole phosphatase activity
DA391_RS19085	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
DA391_RS19090	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
DA391_RS19095	COG0741	lytic transglycosylase activity
DA391_RS19100	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DA391_RS19110	COG2199	diguanylate cyclase activity
DA391_RS19115	COG2885	chlorophyll binding
DA391_RS19120	COG0488	(ABC) transporter
DA391_RS19160	COG1454	alcohol dehydrogenase
DA391_RS19175	COG0604	alcohol dehydrogenase
DA391_RS19190	COG0560	Phosphoserine phosphatase
DA391_RS19195	COG3726	membrane protein affecting hemolysin expression
DA391_RS19200	COG2026	Addiction module toxin, RelE StbE family
DA391_RS19215	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
DA391_RS19230	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DA391_RS19235	COG0084	hydrolase, TatD family'
DA391_RS19240	COG4667	esterase of the alpha-beta hydrolase superfamily
DA391_RS19250	COG2823	Periplasmic or secreted lipoprotein
DA391_RS19255	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
DA391_RS19265	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
DA391_RS19270	COG2813	Specifically methylates the guanine in position
DA391_RS19275	COG0667	Aldo Keto reductase
DA391_RS19310	COG3284	Transcriptional regulator
DA391_RS19320	COG0738	Major facilitator superfamily
DA391_RS19335	COG2192	nodulation
DA391_RS19345	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DA391_RS19345	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DA391_RS19345	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
DA391_RS19350	COG1461	Dihydroxyacetone kinase
DA391_RS19355	COG2376	Dihydroxyacetone kinase
DA391_RS19365	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DA391_RS19370	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DA391_RS19375	COG2235	arginine
DA391_RS19390	COG0859	PFAM glycosyl transferase family 9
DA391_RS19395	COG1070	Carbohydrate kinase
DA391_RS19400	COG2390	Transcriptional regulator
DA391_RS19405	COG1129	ABC transporter
DA391_RS19410	COG1172	Belongs to the binding-protein-dependent transport system permease family
DA391_RS19415	COG1172	Belongs to the binding-protein-dependent transport system permease family
DA391_RS19425	COG1830	Aldolase
DA391_RS19440	COG3550	peptidyl-serine autophosphorylation
DA391_RS19445	COG1396	sequence-specific DNA binding
DA391_RS19460	COG2771	luxR family
DA391_RS19525	COG0582	viral genome integration into host DNA
DA391_RS19535	COG0795	lipopolysaccharide-transporting ATPase activity
DA391_RS19540	COG0795	lipopolysaccharide-transporting ATPase activity
DA391_RS19545	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DA391_RS19550	COG2927	DNA polymerase III (CHI subunit)
DA391_RS19570	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
DA391_RS19580	COG2731	YhcH YjgK YiaL family protein
DA391_RS19590	COG0601	transmembrane transport
DA391_RS19595	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DA391_RS19600	COG0444	Belongs to the ABC transporter superfamily
DA391_RS19605	COG4608	Belongs to the ABC transporter superfamily
DA391_RS19625	COG0602	queuosine metabolic process
DA391_RS19640	COG2188	Transcriptional regulator
DA391_RS19645	COG3624	Phosphonate C-P lyase system protein PhnG
DA391_RS19650	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
DA391_RS19655	COG3626	phosphonate metabolism
DA391_RS19660	COG3627	carbon phosphorus lyase activity
DA391_RS19665	COG4107	phosphonate C-P lyase system protein PhnK
DA391_RS19670	COG4778	phosphonate C-P lyase system protein PhnL
DA391_RS19675	COG3454	Phosphonate metabolism
DA391_RS19680	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
DA391_RS19685	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
DA391_RS19690	COG0702	epimerase
DA391_RS19705	COG3842	ATPase activity
DA391_RS19710	COG0395	ABC-type sugar transport system, permease component
DA391_RS19715	COG1175	transmembrane transport
DA391_RS19720	COG1653	transport
DA391_RS19740	COG1982	Orn Lys Arg decarboxylase major
DA391_RS19745	COG0531	amino acid
DA391_RS19755	COG3153	acetyltransferase
DA391_RS19760	COG3154	lipid carrier protein
DA391_RS19765	COG0826	peptidase U32
DA391_RS19770	COG0826	peptidase U32
DA391_RS19775	COG3681	Belongs to the UPF0597 family
DA391_RS19780	COG0814	amino acid
DA391_RS19785	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DA391_RS19790	COG0513	Belongs to the DEAD box helicase family
DA391_RS19805	COG1185	polyribonucleotide nucleotidyltransferase activity
DA391_RS19815	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DA391_RS19820	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DA391_RS19830	COG0195	Participates in both transcription termination and antitermination
DA391_RS19850	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DA391_RS19860	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DA391_RS19870	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
DA391_RS19875	COG1534	Rna-binding protein
DA391_RS19885	COG2027	D-alanyl-D-alanine carboxypeptidase
DA391_RS19890	COG0745	RESPONSE REGULATOR receiver
DA391_RS19895	COG0642	Histidine kinase
DA391_RS19900	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DA391_RS19905	COG0697	spore germination
DA391_RS19910	COG0211	Belongs to the bacterial ribosomal protein bL27 family
DA391_RS19920	COG0142	geranyltranstransferase activity
DA391_RS19930	COG3423	Transcriptional regulator
DA391_RS19950	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DA391_RS19965	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
DA391_RS19970	COG2105	PFAM AIG2 family protein
DA391_RS19975	COG2911	Protein conserved in bacteria
DA391_RS19985	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DA391_RS19990	COG1253	flavin adenine dinucleotide binding
DA391_RS20000	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
DA391_RS20005	COG1218	3'(2'),5'-bisphosphate nucleotidase
DA391_RS20010	COG0737	Belongs to the 5'-nucleotidase family
DA391_RS20020	COG0545	Peptidyl-prolyl cis-trans isomerase
DA391_RS20025	COG3061	Opacity-associated protein A
DA391_RS20035	COG0359	binds to the 23S rRNA
DA391_RS20040	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DA391_RS20050	COG0360	Binds together with S18 to 16S ribosomal RNA
DA391_RS20065	COG1073	alpha beta
DA391_RS20070	COG3650	response to hydrogen peroxide
DA391_RS20200	COG2369	cell adhesion
DA391_RS20210	COG4373	Mu-like prophage FluMu protein gp28
DA391_RS20285	COG3267	Type II secretory pathway component ExeA
DA391_RS20285	COG3409	Peptidoglycan-binding domain 1 protein
DA391_RS20325	COG4382	Mu-like prophage protein Gp16
DA391_RS20345	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DA391_RS20350	COG0557	exoribonuclease II activity
DA391_RS20355	COG1959	2 iron, 2 sulfur cluster binding
DA391_RS20365	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
DA391_RS20370	COG0330	HflC and HflK could
DA391_RS20375	COG0330	HflC and HflK could
DA391_RS20380	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DA391_RS20390	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DA391_RS20405	COG0802	atpase or kinase
DA391_RS20410	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DA391_RS20410	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
DA391_RS20415	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DA391_RS20440	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
DA391_RS20445	COG1162	GTPase activity
DA391_RS20450	COG0688	phosphatidylethanolamine metabolic process
DA391_RS20455	COG3264	Mechanosensitive ion channel
DA391_RS20455	COG1511	domain protein
DA391_RS20465	COG1053	succinate dehydrogenase
DA391_RS20470	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DA391_RS20475	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
DA391_RS20480	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
DA391_RS20510	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DA391_RS20525	COG0459	protein refolding
DA391_RS20530	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
DA391_RS20545	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
DA391_RS20555	COG4232	protein-disulfide reductase activity
DA391_RS20560	COG3383	formate dehydrogenase (NAD+) activity
DA391_RS20565	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
DA391_RS20565	COG0493	'glutamate synthase
DA391_RS20570	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
DA391_RS20570	COG0493	'glutamate synthase
DA391_RS20575	COG2271	Major facilitator Superfamily
DA391_RS20580	COG1929	Belongs to the glycerate kinase type-1 family
DA391_RS20585	COG2721	sulfolactate sulfo-lyase activity
DA391_RS20590	COG3835	regulator
DA391_RS20595	COG1929	Belongs to the glycerate kinase type-1 family
DA391_RS20600	COG2084	Dehydrogenase
DA391_RS20610	COG1309	transcriptional regulator
DA391_RS20625	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DA391_RS20625	COG0543	2 iron, 2 sulfur cluster binding
DA391_RS20630	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DA391_RS20660	COG0463	Glycosyl transferase, family 2
DA391_RS20675	COG0489	protein tyrosine kinase activity
DA391_RS20685	COG1215	transferase activity, transferring glycosyl groups
DA391_RS20690	COG0457	Tetratricopeptide repeat
DA391_RS20700	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
DA391_RS20710	COG3721	Heme iron utilization protein
DA391_RS20715	COG0702	epimerase
DA391_RS20725	COG4771	TonB-dependent receptor
DA391_RS20730	COG3720	iron ion transport
DA391_RS20735	COG4558	Periplasmic binding protein
DA391_RS20740	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DA391_RS20745	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
DA391_RS20750	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DA391_RS20760	COG4774	siderophore transport
DA391_RS20765	COG3264	Mechanosensitive ion channel
DA391_RS20765	COG1196	nuclear chromosome segregation
DA391_RS20915	COG2197	response regulator
DA391_RS20920	COG2205	protein histidine kinase activity
DA391_RS20960	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DA391_RS21005	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
DA391_RS21015	COG3397	chitin binding
DA391_RS21025	COG0612	Peptidase, M16
DA391_RS21030	COG4178	(ABC) transporter
DA391_RS21035	COG4771	TonB-dependent receptor
DA391_RS21040	COG3712	iron ion homeostasis
DA391_RS21045	COG1595	DNA-templated transcription, initiation
DA391_RS21060	COG3093	addiction module antidote protein HigA
DA391_RS21065	COG0425	Belongs to the sulfur carrier protein TusA family
DA391_RS21070	COG2391	methyltransferase activity
DA391_RS21235	COG1301	dicarboxylic acid transport
DA391_RS21240	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DA391_RS21245	COG3162	membrane
DA391_RS21250	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DA391_RS21305	COG0151	Belongs to the GarS family
DA391_RS21325	COG1515	deoxyribonuclease V activity
DA391_RS21335	COG2816	NAD+ diphosphatase activity
DA391_RS21340	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
DA391_RS21355	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DA391_RS21360	COG2104	thiamine diphosphate biosynthetic process
DA391_RS21375	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DA391_RS21380	COG0085	RNA polymerase activity
DA391_RS21385	COG0222	ribosome binding
DA391_RS21390	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DA391_RS21400	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DA391_RS21405	COG0250	Participates in transcription elongation, termination and antitermination
DA391_RS21445	COG1072	(Pantothenic acid kinase))
DA391_RS21450	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
DA391_RS21450	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
DA391_RS21490	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DA391_RS21495	COG1739	Uncharacterized protein family UPF0029
DA391_RS21505	COG1024	Enoyl-CoA hydratase
DA391_RS21505	COG1250	3-hydroxyacyl-CoA dehydrogenase
DA391_RS21510	COG0183	Belongs to the thiolase family
DA391_RS21520	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
DA391_RS21540	COG0805	protein transport
DA391_RS21550	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DA391_RS21555	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DA391_RS21565	COG2226	methyltransferase
DA391_RS21570	COG1322	Protein conserved in bacteria
DA391_RS21575	COG0586	Pfam SNARE associated Golgi protein
DA391_RS21580	COG1966	Carbon starvation protein
DA391_RS21595	COG0412	Dienelactone hydrolase
DA391_RS21600	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
DA391_RS21605	COG0583	DNA-binding transcription factor activity
DA391_RS21610	COG0697	spore germination
DA391_RS21615	COG0679	Auxin Efflux Carrier
DA391_RS21620	COG0584	glycerophosphoryl diester phosphodiesterase
DA391_RS21625	COG3842	ATPase activity
DA391_RS21630	COG0395	ABC-type sugar transport system, permease component
DA391_RS21635	COG1175	transmembrane transport
DA391_RS21640	COG1653	transport
DA391_RS21675	COG0410	ABC transporter
DA391_RS21685	COG4177	L-phenylalanine transmembrane transporter activity
DA391_RS21695	COG0683	leucine binding
DA391_RS21700	COG0456	acetyltransferase
DA391_RS21715	COG2177	Part of the ABC transporter FtsEX involved in
DA391_RS21720	COG2884	Cell division ATP-binding protein ftsE
DA391_RS21725	COG0552	protein localization to endoplasmic reticulum
DA391_RS21725	COG0552	protein localization to endoplasmic reticulum
DA391_RS21730	COG0742	ribosomal rna small subunit methyltransferase
DA391_RS21735	COG3776	membrane
DA391_RS21750	COG3714	YhhN family
DA391_RS21760	COG0425	Belongs to the sulfur carrier protein TusA family
DA391_RS21765	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
DA391_RS21775	COG0247	lactate metabolic process
DA391_RS21785	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
DA391_RS21790	COG2271	Major facilitator Superfamily
DA391_RS21795	COG0584	glycerophosphoryl diester phosphodiesterase
DA391_RS21800	COG0561	phosphatase activity
DA391_RS21805	COG2267	carboxylic ester hydrolase activity
DA391_RS21810	COG1280	lysine exporter protein (LysE YggA)
DA391_RS21815	COG1280	lysine exporter protein (LysE YggA)
DA391_RS21820	COG0514	ATP-dependent DNA helicase (RecQ)
DA391_RS21825	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
DA391_RS21830	COG2050	protein possibly involved in aromatic compounds catabolism
DA391_RS21850	COG5564	TIM-barrel signal transduction protein
DA391_RS21865	COG0210	DNA helicase
DA391_RS21870	COG1011	Hydrolase
DA391_RS21875	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
DA391_RS21880	COG3159	Protein conserved in bacteria
DA391_RS21885	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
DA391_RS21890	COG5567	small periplasmic lipoprotein
DA391_RS21900	COG3072	Adenylate cyclase
DA391_RS21905	COG0181	hydroxymethylbilane synthase activity
DA391_RS21910	COG1587	Uroporphyrinogen-III synthase
DA391_RS21915	COG2959	enzyme of heme biosynthesis
DA391_RS21920	COG3071	HemY protein
DA391_RS21945	COG1113	amino acid transport
DA391_RS21960	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DA391_RS21965	COG2244	polysaccharide biosynthetic process
DA391_RS21970	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DA391_RS21975	COG0456	acetyltransferase
DA391_RS21980	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
DA391_RS21985	COG1088	dTDP-glucose 4,6-dehydratase activity
DA391_RS21990	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
DA391_RS21995	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
DA391_RS22000	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
DA391_RS22005	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DA391_RS22010	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
DA391_RS22015	COG3118	belongs to the thioredoxin family
DA391_RS22025	COG0248	Ppx GppA phosphatase
DA391_RS22040	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DA391_RS22050	COG3121	Chaperone
DA391_RS22065	COG3121	Chaperone
DA391_RS22070	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DA391_RS22075	COG0583	DNA-binding transcription factor activity
DA391_RS22085	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DA391_RS22090	COG0129	dihydroxy-acid dehydratase activity
DA391_RS22095	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DA391_RS22100	COG3978	acetolactate synthase activity
DA391_RS22120	COG3085	chromosome segregation
DA391_RS22125	COG0583	DNA-binding transcription factor activity
DA391_RS22130	COG1172	Belongs to the binding-protein-dependent transport system permease family
DA391_RS22135	COG1172	Belongs to the binding-protein-dependent transport system permease family
DA391_RS22140	COG1129	ABC transporter
DA391_RS22145	COG1879	ABC-type sugar transport system periplasmic component
DA391_RS22190	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
DA391_RS22200	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DA391_RS22215	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DA391_RS22225	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
DA391_RS22225	COG0678	peroxiredoxin activity
DA391_RS22230	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DA391_RS22255	COG1629	transport
DA391_RS22260	COG0165	Argininosuccinate lyase
DA391_RS22280	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
DA391_RS22290	COG2814	Major facilitator Superfamily
DA391_RS22295	COG1494	fructose-1,6-bisphosphatase
DA391_RS22300	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DA391_RS22305	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DA391_RS22315	COG3074	FtsZ-dependent cytokinesis
DA391_RS22320	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
DA391_RS22325	COG1575	Belongs to the MenA family. Type 1 subfamily
DA391_RS22330	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
DA391_RS22335	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
DA391_RS22340	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
DA391_RS22345	COG1609	Transcriptional regulator
DA391_RS22350	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DA391_RS22360	COG0254	rRNA binding
DA391_RS22365	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
DA391_RS22370	COG0626	cystathionine gamma-synthase activity
DA391_RS22375	COG0527	aspartate kinase activity
DA391_RS22375	COG0460	homoserine dehydrogenase
DA391_RS22385	COG3152	Membrane
DA391_RS22405	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
DA391_RS22415	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
DA391_RS22420	COG3678	ATP-independent chaperone mediated protein folding
DA391_RS22425	COG0745	RESPONSE REGULATOR receiver
DA391_RS22430	COG2205	protein histidine kinase activity
DA391_RS22435	COG2169	Transcriptional regulator
DA391_RS22435	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DA391_RS22440	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
DA391_RS22445	COG1045	serine acetyltransferase
DA391_RS22450	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DA391_RS22455	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
DA391_RS22460	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
DA391_RS22465	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DA391_RS22470	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
DA391_RS22475	COG4942	peptidase
DA391_RS22480	COG2861	carbohydrate metabolic process
DA391_RS22490	COG0156	8-amino-7-oxononanoate synthase activity
DA391_RS22495	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DA391_RS22500	COG0859	PFAM glycosyl transferase family 9
DA391_RS22505	COG0859	PFAM glycosyl transferase family 9
DA391_RS22510	COG1519	Transferase
DA391_RS22525	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DA391_RS22530	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DA391_RS22535	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DA391_RS22550	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DA391_RS22555	COG0756	dUTP diphosphatase activity
DA391_RS22560	COG1309	transcriptional regulator
DA391_RS22570	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
DA391_RS22575	COG2199	diguanylate cyclase activity
DA391_RS22575	COG2200	EAL domain
DA391_RS22580	COG4608	Belongs to the ABC transporter superfamily
DA391_RS22585	COG0444	Belongs to the ABC transporter superfamily
DA391_RS22590	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DA391_RS22595	COG0601	transmembrane transport
DA391_RS22600	COG0747	negative chemotaxis
DA391_RS22610	COG2831	hemolysin activation secretion protein
DA391_RS22620	COG2271	Major facilitator Superfamily
DA391_RS22625	COG3851	Histidine kinase
DA391_RS22630	COG2197	response regulator
DA391_RS22635	COG2194	sulfuric ester hydrolase activity
DA391_RS22640	COG1764	response to oxidative stress
DA391_RS22655	COG2986	histidine ammonia-lyase
DA391_RS22660	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
DA391_RS22665	COG5001	Diguanylate cyclase
DA391_RS22670	COG1024	Enoyl-CoA hydratase
DA391_RS22675	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DA391_RS22685	COG2860	membrane
DA391_RS22690	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DA391_RS22700	COG1758	RNA polymerase activity
DA391_RS22705	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DA391_RS22710	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DA391_RS22715	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DA391_RS22720	COG0786	glutamate:sodium symporter activity
DA391_RS22725	COG2233	PERMEase
DA391_RS22730	COG2982	Protein involved in outer membrane biogenesis
DA391_RS22750	COG0456	acetyltransferase
DA391_RS22760	COG1295	ribonuclease BN
DA391_RS22765	COG1011	Hydrolase
DA391_RS22780	COG3852	Histidine kinase
DA391_RS22790	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DA391_RS22800	COG3078	GTPase activator activity
DA391_RS22810	COG0218	Necessary for normal cell division and for the maintenance of normal septation
DA391_RS22815	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DA391_RS22815	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DA391_RS22820	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DA391_RS22825	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
DA391_RS22830	COG3084	Protein conserved in bacteria
DA391_RS22840	COG1763	Mo-molybdopterin cofactor biosynthetic process
DA391_RS22870	COG2186	Transcriptional regulator
DA391_RS22875	COG0477	Major facilitator Superfamily
DA391_RS22880	COG1609	Transcriptional regulator
DA391_RS22885	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DA391_RS22890	COG1879	ABC-type sugar transport system periplasmic component
DA391_RS22895	COG1172	Belongs to the binding-protein-dependent transport system permease family
DA391_RS22905	COG1869	D-ribose catabolic process
DA391_RS22910	COG3158	transport of potassium into the cell
DA391_RS22915	COG0714	Associated with various cellular activities
DA391_RS22920	COG2425	protein containing a von Willebrand factor type A (vWA) domain
DA391_RS22930	COG2502	aspartate--ammonia ligase
DA391_RS22935	COG1522	sequence-specific DNA binding
DA391_RS22940	COG0716	FMN binding
DA391_RS22945	COG0445	tRNA wobble uridine modification
DA391_RS22950	COG0357	Ribosomal RNA small subunit methyltransferase G
DA391_RS22955	COG3312	ion transport
DA391_RS22960	COG0356	it plays a direct role in the translocation of protons across the membrane
DA391_RS22970	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DA391_RS22975	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DA391_RS22980	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
DA391_RS22985	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DA391_RS22990	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DA391_RS22995	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DA391_RS23000	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DA391_RS23010	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DA391_RS23015	COG0573	inorganic phosphate transmembrane transporter activity
DA391_RS23020	COG0581	inorganic phosphate transmembrane transporter activity
DA391_RS23030	COG0704	Plays a role in the regulation of phosphate uptake
DA391_RS23035	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DA391_RS23040	COG0765	amino acid transport
DA391_RS23045	COG0765	amino acid transport
DA391_RS23050	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DA391_RS23055	COG2252	PERMEase
DA391_RS23070	COG4191	Histidine kinase
DA391_RS23075	COG0431	NADPH-dependent FMN reductase
DA391_RS23080	COG0840	transmembrane signaling receptor activity
DA391_RS23085	COG2011	ABC-type metal ion transport system permease component
DA391_RS23090	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DA391_RS23120	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
DA391_RS23125	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
DA391_RS23130	COG0706	membrane insertase activity
DA391_RS23140	COG0594	ribonuclease P activity
DA391_RS23145	COG0230	Belongs to the bacterial ribosomal protein bL34 family
DA391_RS23190	COG0210	DNA helicase
DA391_RS23350	COG4680	protein conserved in bacteria
DA391_RS23355	COG5499	transcription regulator containing HTH domain
DA391_RS23725	COG2197	response regulator
DA391_RS23730	COG3121	Chaperone
DA391_RS23735	COG3188	usher protein
DA391_RS23765	COG3549	Plasmid maintenance system killer
DA391_RS23770	COG3093	addiction module antidote protein HigA
DA391_RS23915	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DA391_RS23940	COG0250	Participates in transcription elongation, termination and antitermination
DA391_RS23975	COG3504	Conjugal transfer protein
DA391_RS23985	COG3451	type IV secretory pathway VirB4
DA391_RS23990	COG5268	conjugation
DA391_RS24000	COG4962	Type ii secretion system protein e
DA391_RS24120	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone