locus-tag	class	description
OP862_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
OP862_RS00010	COG0592	DNA-directed DNA polymerase activity
OP862_RS00020	COG0187	DNA topoisomerase II activity
OP862_RS00025	COG0561	phosphatase activity
OP862_RS00030	COG2423	ornithine cyclodeaminase activity
OP862_RS00045	COG0823	Involved in the tonB-independent uptake of proteins
OP862_RS00050	COG5645	(Lipo)protein
OP862_RS00065	COG0569	domain protein
OP862_RS00065	COG2985	domain, Protein
OP862_RS00070	COG3977	Valine--pyruvate aminotransferase
OP862_RS00075	COG0366	Alpha amylase catalytic
OP862_RS00095	COG2885	chlorophyll binding
OP862_RS00110	COG2818	Glycosylase
OP862_RS00120	COG0752	glycyl-tRNA synthetase alpha subunit
OP862_RS00125	COG0751	glycine-tRNA ligase activity
OP862_RS00140	COG3276	selenocysteine insertion sequence binding
OP862_RS00145	COG1921	L-seryl-tRNASec selenium transferase activity
OP862_RS00150	COG3058	Necessary for formate dehydrogenase activity
OP862_RS00155	COG2864	formate dehydrogenase
OP862_RS00160	COG0437	4 iron, 4 sulfur cluster binding
OP862_RS00170	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
OP862_RS00175	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
OP862_RS00180	COG0840	transmembrane signaling receptor activity
OP862_RS00185	COG2258	MOSC domain
OP862_RS00205	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
OP862_RS00215	COG3722	fumarate hydratase activity
OP862_RS00220	COG0246	Mannitol dehydrogenase
OP862_RS00225	COG2213	PTS system mannitol-specific
OP862_RS00225	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
OP862_RS00230	COG3274	enterobacterial common antigen metabolic process
OP862_RS00240	COG1335	isochorismatase
OP862_RS00250	COG3188	usher protein
OP862_RS00255	COG3121	Chaperone
OP862_RS00265	COG1070	Carbohydrate kinase
OP862_RS00270	COG2115	Belongs to the xylose isomerase family
OP862_RS00275	COG4213	ABC transporter substrate-binding protein
OP862_RS00285	COG4214	carbohydrate transport
OP862_RS00290	COG1609	Transcriptional regulator
OP862_RS00290	COG2207	Transcriptional regulator
OP862_RS00300	COG0582	viral genome integration into host DNA
OP862_RS00305	COG0582	viral genome integration into host DNA
OP862_RS00310	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
OP862_RS00390	COG3210	domain, Protein
OP862_RS00395	COG2831	hemolysin activation secretion protein
OP862_RS00425	COG3596	GTP binding
OP862_RS00455	COG2003	Belongs to the UPF0758 family
OP862_RS00550	COG4529	Protein conserved in bacteria
OP862_RS00570	COG1561	YicC-like family, N-terminal region
OP862_RS00575	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
OP862_RS00580	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
OP862_RS00585	COG1301	dicarboxylic acid transport
OP862_RS00590	COG0612	Peptidase, M16
OP862_RS00595	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
OP862_RS00600	COG1942	4-Oxalocrotonate Tautomerase
OP862_RS00605	COG2200	EAL domain
OP862_RS00610	COG2982	Protein involved in outer membrane biogenesis
OP862_RS00615	COG2134	cdp-diacylglycerol pyrophosphatase
OP862_RS00620	COG1295	ribonuclease BN
OP862_RS00625	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
OP862_RS00630	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
OP862_RS00645	COG0742	ribosomal rna small subunit methyltransferase
OP862_RS00660	COG0589	response to stress
OP862_RS00670	COG0306	phosphate transporter
OP862_RS00675	COG2081	HI0933 family
OP862_RS00730	COG3210	domain, Protein
OP862_RS00735	COG2831	hemolysin activation secretion protein
OP862_RS00770	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
OP862_RS00775	COG2076	Multidrug Resistance protein
OP862_RS00785	COG0590	tRNA wobble adenosine to inosine editing
OP862_RS00805	COG2197	response regulator
OP862_RS00820	COG0583	DNA-binding transcription factor activity
OP862_RS00825	COG2814	Major facilitator Superfamily
OP862_RS00835	COG2814	Major facilitator Superfamily
OP862_RS00845	COG3718	enzyme involved in inositol metabolism
OP862_RS00865	COG0673	inositol 2-dehydrogenase activity
OP862_RS00870	COG1082	Xylose isomerase domain protein TIM barrel
OP862_RS00875	COG1247	-acetyltransferase
OP862_RS00880	COG1741	Belongs to the pirin family
OP862_RS00885	COG1609	Transcriptional regulator
OP862_RS00890	COG2610	gluconate transmembrane transporter activity
OP862_RS00895	COG3265	gluconokinase activity
OP862_RS00900	COG2095	MarC family integral membrane protein
OP862_RS00905	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
OP862_RS00910	COG3275	phosphorelay sensor kinase activity
OP862_RS00915	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
OP862_RS00920	COG1523	belongs to the glycosyl hydrolase 13 family
OP862_RS00930	COG0297	glycogen (starch) synthase activity
OP862_RS00935	COG0058	SHG alpha-glucan phosphorylase activity
OP862_RS00940	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
OP862_RS00945	COG1349	DNA-binding transcription factor activity
OP862_RS00950	COG0705	Rhomboid family
OP862_RS00965	COG2909	trisaccharide binding
OP862_RS00970	COG0058	SHG alpha-glucan phosphorylase activity
OP862_RS00975	COG1640	4-alpha-glucanotransferase
OP862_RS00980	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
OP862_RS00980	COG0316	Belongs to the HesB IscA family
OP862_RS00985	COG1040	competence protein
OP862_RS00990	COG0596	Alpha beta hydrolase
OP862_RS01010	COG1918	ferrous iron import across plasma membrane
OP862_RS01015	COG2183	response to ionizing radiation
OP862_RS01020	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
OP862_RS01045	COG3121	Chaperone
OP862_RS01050	COG3188	usher protein
OP862_RS01070	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
OP862_RS01080	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
OP862_RS01085	COG1011	Hydrolase
OP862_RS01095	COG0494	nUDIX hydrolase
OP862_RS01100	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
OP862_RS01125	COG4796	Type ii and iii secretion system protein
OP862_RS01130	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
OP862_RS01150	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
OP862_RS01160	COG0180	Tryptophanyl-tRNA synthetase
OP862_RS01165	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
OP862_RS01165	COG1648	precorrin-2 dehydrogenase activity
OP862_RS01180	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
OP862_RS01185	COG0402	S-adenosylhomocysteine deaminase activity
OP862_RS01190	COG0738	Major facilitator superfamily
OP862_RS01200	COG4771	TonB-dependent receptor
OP862_RS01210	COG1486	melibiose metabolic process
OP862_RS01215	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
OP862_RS01220	COG0433	COG0433 Predicted ATPase
OP862_RS01270	COG1470	cell adhesion involved in biofilm formation
OP862_RS01270	COG1388	LysM domain
OP862_RS01290	COG1289	transmembrane transporter activity
OP862_RS01300	COG1765	OsmC-like protein
OP862_RS01305	COG3954	Phosphoribulokinase
OP862_RS01310	COG3089	Belongs to the UPF0270 family
OP862_RS01315	COG0429	hydrolase of the alpha beta-hydrolase fold
OP862_RS01330	COG4521	taurine ABC transporter
OP862_RS01340	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
OP862_RS01345	COG2175	clavaminate synthase activity
OP862_RS01355	COG0488	(ABC) transporter
OP862_RS01360	COG2249	NAD(P)H dehydrogenase (quinone) activity
OP862_RS01370	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
OP862_RS01375	COG1047	Peptidyl-prolyl cis-trans
OP862_RS01385	COG0545	Peptidyl-prolyl cis-trans isomerase
OP862_RS01390	COG2964	Protein conserved in bacteria
OP862_RS01395	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
OP862_RS01405	COG2168	tRNA wobble position uridine thiolation
OP862_RS01410	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
OP862_RS01415	COG0049	tRNA binding
OP862_RS01425	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
OP862_RS01440	COG0051	transcription antitermination factor activity, RNA binding
OP862_RS01445	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
OP862_RS01450	COG0088	Forms part of the polypeptide exit tunnel
OP862_RS01455	COG0089	rRNA binding
OP862_RS01465	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
OP862_RS01470	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
OP862_RS01475	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
OP862_RS01480	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
OP862_RS01485	COG0255	Belongs to the universal ribosomal protein uL29 family
OP862_RS01490	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
OP862_RS01495	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
OP862_RS01510	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
OP862_RS01520	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
OP862_RS01525	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
OP862_RS01530	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
OP862_RS01535	COG1841	ribosomal large subunit assembly
OP862_RS01540	COG0200	Binds to the 23S rRNA
OP862_RS01545	COG0201	protein transport
OP862_RS01550	COG0257	Belongs to the bacterial ribosomal protein bL36 family
OP862_RS01555	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
OP862_RS01560	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
OP862_RS01565	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
OP862_RS01575	COG0203	ribosomal protein L17
OP862_RS01585	COG0789	Transcriptional regulator
OP862_RS01595	COG1970	mechanosensitive ion channel activity
OP862_RS01605	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
OP862_RS01605	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
OP862_RS01610	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
OP862_RS01615	COG0242	peptide deformylase activity
OP862_RS01620	COG0758	DNA mediated transformation
OP862_RS01630	COG0551	DNA topoisomerase type I activity
OP862_RS01635	COG0009	L-threonylcarbamoyladenylate synthase
OP862_RS01640	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
OP862_RS01645	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
OP862_RS01670	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
OP862_RS01675	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
OP862_RS01680	COG2224	Isocitrate lyase
OP862_RS01685	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
OP862_RS01690	COG1414	Transcriptional regulator
OP862_RS01695	COG0646	methionine synthase
OP862_RS01695	COG1410	methionine synthase
OP862_RS01705	COG0527	aspartate kinase activity
OP862_RS01720	COG3833	ABC-type maltose transport systems, permease component
OP862_RS01725	COG1175	transmembrane transport
OP862_RS01730	COG2182	Extracellular solute-binding protein
OP862_RS01740	COG4580	involved in the transport of maltose and maltodextrins
OP862_RS01750	COG3161	chorismate lyase activity
OP862_RS01760	COG2937	Belongs to the GPAT DAPAT family
OP862_RS01765	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
OP862_RS01770	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
OP862_RS01775	COG3237	CsbD-like
OP862_RS01780	COG0735	belongs to the Fur family
OP862_RS01790	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
OP862_RS01815	COG1448	Aminotransferase
OP862_RS01820	COG2315	Protein conserved in bacteria
OP862_RS01825	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
OP862_RS01830	COG0629	single-stranded DNA binding
OP862_RS01850	COG2252	PERMEase
OP862_RS01855	COG0025	NhaP-type Na H and K H
OP862_RS01860	COG0583	DNA-binding transcription factor activity
OP862_RS01865	COG1380	Effector of murein hydrolase LrgA
OP862_RS01875	COG1126	abc transporter atp-binding protein
OP862_RS01880	COG0765	amino acid transport
OP862_RS01885	COG4597	amino acid ABC transporter
OP862_RS01890	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
OP862_RS01905	COG1560	Kdo2-lipid A biosynthetic process
OP862_RS01915	COG1129	ABC transporter
OP862_RS01920	COG1172	Belongs to the binding-protein-dependent transport system permease family
OP862_RS01930	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
OP862_RS01935	COG0517	IMP dehydrogenase activity
OP862_RS01935	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
OP862_RS01940	COG0471	metal ion transport
OP862_RS01945	COG1278	Cold shock
OP862_RS01950	COG1278	Cold shock
OP862_RS01955	COG3133	Outer membrane lipoprotein
OP862_RS01970	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
OP862_RS01975	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
OP862_RS01980	COG2264	protein methyltransferase activity
OP862_RS01985	COG4145	pantothenate transmembrane transporter activity
OP862_RS01990	COG3924	membrane
OP862_RS01995	COG0439	Biotin carboxylase
OP862_RS02000	COG0511	ligase activity, forming carbon-carbon bonds
OP862_RS02010	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
OP862_RS02020	COG0604	alcohol dehydrogenase
OP862_RS02025	COG2200	EAL domain
OP862_RS02025	COG2199	diguanylate cyclase activity
OP862_RS02030	COG1077	Cell shape determining protein MreB Mrl
OP862_RS02035	COG1792	Involved in formation and maintenance of cell shape
OP862_RS02040	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
OP862_RS02045	COG0424	maF-like protein
OP862_RS02050	COG1530	ribonuclease E activity
OP862_RS02055	COG3164	Protein of unknown function
OP862_RS02060	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
OP862_RS02065	COG0312	modulator of DNA gyrase
OP862_RS02070	COG0583	DNA-binding transcription factor activity
OP862_RS02080	COG1566	PFAM secretion protein HlyD family protein
OP862_RS02085	COG1289	transmembrane transporter activity
OP862_RS02100	COG2732	(Barnase) inhibitor
OP862_RS02105	COG3028	Belongs to the UPF0307 family
OP862_RS02110	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
OP862_RS02210	COG4695	Portal protein
OP862_RS02355	COG0312	modulator of DNA gyrase
OP862_RS02365	COG3783	Cytochrome b(562)
OP862_RS02370	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
OP862_RS02400	COG3964	amidohydrolase
OP862_RS02415	COG3711	transcriptional antiterminator
OP862_RS02415	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
OP862_RS02425	COG1609	Transcriptional regulator
OP862_RS02430	COG1263	PTS System
OP862_RS02430	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
OP862_RS02435	COG0366	Alpha amylase catalytic
OP862_RS02465	COG2308	Evidence 4 Homologs of previously reported genes of
OP862_RS02475	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
OP862_RS02480	COG0540	Belongs to the ATCase OTCase family
OP862_RS02485	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
OP862_RS02505	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
OP862_RS02510	COG1137	ATPase activity
OP862_RS02515	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
OP862_RS02520	COG3117	lipopolysaccharide transmembrane transporter activity
OP862_RS02525	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
OP862_RS02530	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
OP862_RS02530	COG0517	IMP dehydrogenase activity
OP862_RS02535	COG0530	calcium, potassium:sodium antiporter activity
OP862_RS02540	COG1127	ABC transporter
OP862_RS02545	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
OP862_RS02550	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
OP862_RS02555	COG2854	intermembrane phospholipid transfer
OP862_RS02560	COG3113	response to antibiotic
OP862_RS02565	COG5007	Belongs to the BolA IbaG family
OP862_RS02570	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
OP862_RS02575	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
OP862_RS02580	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
OP862_RS02585	COG3105	Protein conserved in bacteria
OP862_RS02590	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
OP862_RS02595	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
OP862_RS02600	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
OP862_RS02605	COG0625	glutathione transferase activity
OP862_RS02610	COG2969	positive regulation of protein catabolic process
OP862_RS02620	COG0493	'glutamate synthase
OP862_RS02625	COG0070	glutamate synthase
OP862_RS02625	COG0069	glutamate synthase activity
OP862_RS02625	COG0067	glutamate synthase
OP862_RS02630	COG1242	4 iron, 4 sulfur cluster binding
OP862_RS02635	COG5002	protein histidine kinase activity
OP862_RS02635	COG2198	Histidine kinase
OP862_RS02635	COG0784	Response regulator, receiver
OP862_RS02640	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
OP862_RS02645	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
OP862_RS02650	COG2823	Periplasmic or secreted lipoprotein
OP862_RS02655	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
OP862_RS02660	COG0792	nuclease activity
OP862_RS02670	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
OP862_RS02705	COG1064	alcohol dehydrogenase
OP862_RS02710	COG1741	Belongs to the pirin family
OP862_RS02715	COG0583	DNA-binding transcription factor activity
OP862_RS02720	COG0435	Glutathione S-transferase
OP862_RS02725	COG2259	Doxx family
OP862_RS02735	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
OP862_RS02740	COG4575	ribosome binding
OP862_RS02755	COG0586	Pfam SNARE associated Golgi protein
OP862_RS02770	COG2271	Major facilitator Superfamily
OP862_RS02775	COG1904	glucuronate isomerase
OP862_RS02780	COG0246	Mannitol dehydrogenase
OP862_RS02785	COG2721	sulfolactate sulfo-lyase activity
OP862_RS02795	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
OP862_RS02800	COG0861	Integral membrane protein TerC family
OP862_RS02810	COG0673	inositol 2-dehydrogenase activity
OP862_RS02815	COG1451	nucleotide metabolic process
OP862_RS02820	COG2813	Specifically methylates the guanine in position
OP862_RS02830	COG1902	pentaerythritol trinitrate reductase activity
OP862_RS02830	COG0446	pyridine nucleotide-disulphide oxidoreductase
OP862_RS02835	COG3247	response to pH
OP862_RS02845	COG0800	Aldolase
OP862_RS02850	COG2271	Major facilitator Superfamily
OP862_RS02865	COG1454	alcohol dehydrogenase
OP862_RS02870	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
OP862_RS02890	COG0358	DNA primase activity
OP862_RS02895	COG0828	Belongs to the bacterial ribosomal protein bS21 family
OP862_RS02900	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
OP862_RS02905	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
OP862_RS02910	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
OP862_RS02915	COG1968	undecaprenyl-diphosphatase activity
OP862_RS02920	COG0617	tRNA 3'-terminal CCA addition
OP862_RS02925	COG4991	sh3 domain protein
OP862_RS02930	COG3025	triphosphatase activity
OP862_RS02935	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
OP862_RS02940	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
OP862_RS02940	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
OP862_RS02945	COG0531	amino acid
OP862_RS02955	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
OP862_RS02960	COG3384	dioxygenase
OP862_RS02965	COG0754	glutathionylspermidine amidase activity
OP862_RS02970	COG5463	Belongs to the UPF0441 family
OP862_RS02975	COG1538	Outer membrane efflux protein
OP862_RS02980	COG0494	nUDIX hydrolase
OP862_RS02985	COG3151	Protein conserved in bacteria
OP862_RS02990	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
OP862_RS02995	COG3150	esterase
OP862_RS03010	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
OP862_RS03015	COG2249	NAD(P)H dehydrogenase (quinone) activity
OP862_RS03025	COG0204	Acyl-transferase
OP862_RS03030	COG2132	Multicopper oxidase
OP862_RS03040	COG0656	L-ascorbic acid biosynthetic process
OP862_RS03045	COG1979	alcohol dehydrogenase
OP862_RS03050	COG2207	Transcriptional regulator
OP862_RS03055	COG0586	Pfam SNARE associated Golgi protein
OP862_RS03060	COG0626	cystathionine gamma-synthase activity
OP862_RS03070	COG0848	biopolymer transport protein
OP862_RS03125	COG4964	Belongs to the GSP D family
OP862_RS03150	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
OP862_RS03155	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
OP862_RS03180	COG1120	ATPase activity
OP862_RS03185	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
OP862_RS03190	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
OP862_RS03210	COG1609	Transcriptional regulator
OP862_RS03215	COG4592	Periplasmic binding protein
OP862_RS03220	COG0840	transmembrane signaling receptor activity
OP862_RS03235	COG3710	Transcriptional regulator
OP862_RS03240	COG3133	Outer membrane lipoprotein
OP862_RS03245	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
OP862_RS03250	COG0437	4 iron, 4 sulfur cluster binding
OP862_RS03255	COG5557	Pfam Polysulphide reductase, NrfD
OP862_RS03260	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
OP862_RS03265	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
OP862_RS03270	COG1773	rubredoxin
OP862_RS03280	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
OP862_RS03285	COG0298	carbon dioxide binding
OP862_RS03290	COG0409	Hydrogenase expression formation protein
OP862_RS03295	COG0309	Hydrogenase expression formation protein (HypE)
OP862_RS03300	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
OP862_RS03310	COG5001	Diguanylate cyclase
OP862_RS03315	COG0471	metal ion transport
OP862_RS03320	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
OP862_RS03325	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
OP862_RS03335	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
OP862_RS03350	COG4303	Ethanolamine ammonia lyase large subunit
OP862_RS03355	COG4302	ethanolamine ammonia-lyase activity
OP862_RS03360	COG0477	Major facilitator Superfamily
OP862_RS03385	COG1609	Transcriptional regulator
OP862_RS03390	COG0477	Major facilitator Superfamily
OP862_RS03395	COG4607	ABC-type enterochelin transport system periplasmic component
OP862_RS03405	COG4605	iron ion homeostasis
OP862_RS03410	COG4604	ABC transporter, ATP-binding protein
OP862_RS03415	COG0024	Methionine aminopeptidase
OP862_RS03435	COG2222	sugar isomerase
OP862_RS03440	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
OP862_RS03445	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
OP862_RS03450	COG3716	PTS system mannose fructose sorbose family IID component
OP862_RS03460	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
OP862_RS03470	COG1349	DNA-binding transcription factor activity
OP862_RS03475	COG2226	methyltransferase
OP862_RS03480	COG0747	negative chemotaxis
OP862_RS03485	COG0601	transmembrane transport
OP862_RS03490	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
OP862_RS03495	COG0444	Belongs to the ABC transporter superfamily
OP862_RS03500	COG1124	(ABC) transporter
OP862_RS03505	COG2831	hemolysin activation secretion protein
OP862_RS03510	COG3210	domain, Protein
OP862_RS03560	COG2885	chlorophyll binding
OP862_RS03655	COG1228	amidohydrolase
OP862_RS03670	COG1289	transmembrane transporter activity
OP862_RS03740	COG4964	Belongs to the GSP D family
OP862_RS03790	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
OP862_RS03810	COG1388	LysM domain
OP862_RS03810	COG2373	Large extracellular alpha-helical protein
OP862_RS03810	COG4932	domain protein
OP862_RS03830	COG0840	transmembrane signaling receptor activity
OP862_RS03835	COG2197	response regulator
OP862_RS03860	COG2747	anti-sigma28 factor FlgM
OP862_RS03870	COG1815	bacterial-type flagellum-dependent cell motility
OP862_RS03880	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
OP862_RS03920	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
OP862_RS03925	COG1191	sigma factor activity
OP862_RS03950	COG0643	Histidine kinase
OP862_RS03950	COG2198	Histidine kinase
OP862_RS03955	COG0835	chemotaxis
OP862_RS04000	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
OP862_RS04010	COG0745	RESPONSE REGULATOR receiver
OP862_RS04020	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
OP862_RS04025	COG1677	Flagellar hook-basal body complex protein FliE
OP862_RS04030	COG1766	The M ring may be actively involved in energy transduction
OP862_RS04040	COG1317	bacterial-type flagellum organization
OP862_RS04045	COG1157	protein secretion by the type III secretion system
OP862_RS04055	COG3144	bacterial-type flagellum assembly
OP862_RS04060	COG1580	Controls the rotational direction of flagella during chemotaxis
OP862_RS04070	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
OP862_RS04085	COG1987	bacterial-type flagellum assembly
OP862_RS04100	COG0745	RESPONSE REGULATOR receiver
OP862_RS04125	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
OP862_RS04140	COG0673	inositol 2-dehydrogenase activity
OP862_RS04145	COG0823	Involved in the tonB-independent uptake of proteins
OP862_RS04150	COG1653	transport
OP862_RS04155	COG1082	Xylose isomerase domain protein TIM barrel
OP862_RS04160	COG0626	cystathionine gamma-synthase activity
OP862_RS04165	COG0814	amino acid
OP862_RS04170	COG0583	DNA-binding transcription factor activity
OP862_RS04180	COG3655	Transcriptional regulator
OP862_RS04195	COG3121	Chaperone
OP862_RS04200	COG3188	usher protein
OP862_RS04215	COG2197	response regulator
OP862_RS04230	COG1982	Orn Lys Arg decarboxylase major
OP862_RS04235	COG0741	lytic transglycosylase activity
OP862_RS04245	COG1194	a g-specific adenine glycosylase
OP862_RS04250	COG0220	tRNA (guanine-N7-)-methyltransferase activity
OP862_RS04255	COG3171	Protein conserved in bacteria
OP862_RS04270	COG0635	Involved in the biosynthesis of porphyrin-containing compound
OP862_RS04275	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
OP862_RS04280	COG1872	DUF167
OP862_RS04285	COG0762	integral membrane protein
OP862_RS04290	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
OP862_RS04295	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
OP862_RS04300	COG2805	Type II/IV secretion system protein
OP862_RS04310	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
OP862_RS04315	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
OP862_RS04320	COG1678	Uncharacterized ACR, COG1678
OP862_RS04325	COG0189	ligase activity
OP862_RS04330	COG1385	rRNA (uridine-N3-)-methyltransferase activity
OP862_RS04335	COG2356	endonuclease I
OP862_RS04340	COG3091	SprT-like family
OP862_RS04345	COG0640	Transcriptional regulator
OP862_RS04360	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
OP862_RS04365	COG1166	arginine decarboxylase activity
OP862_RS04375	COG0501	Belongs to the peptidase M48B family
OP862_RS04385	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
OP862_RS04390	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
OP862_RS04395	COG0126	phosphoglycerate kinase activity
OP862_RS04400	COG0191	fructose-bisphosphate aldolase activity
OP862_RS04415	COG1279	arginine transmembrane transporter activity
OP862_RS04425	COG0583	DNA-binding transcription factor activity
OP862_RS04430	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
OP862_RS04435	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
OP862_RS04440	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
OP862_RS04450	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
OP862_RS04455	COG3079	Belongs to the UPF0149 family
OP862_RS04460	COG0006	proline dipeptidase activity
OP862_RS04465	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
OP862_RS04470	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
OP862_RS04475	COG0404	The glycine cleavage system catalyzes the degradation of glycine
OP862_RS04480	COG0509	glycine decarboxylation via glycine cleavage system
OP862_RS04485	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
OP862_RS04485	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
OP862_RS04490	COG1028	Short-chain dehydrogenase reductase Sdr
OP862_RS04495	COG1272	protein, Hemolysin III
OP862_RS04500	COG0354	folic acid binding
OP862_RS04515	COG0745	RESPONSE REGULATOR receiver
OP862_RS04520	COG2205	protein histidine kinase activity
OP862_RS04525	COG4452	Inner membrane protein CreD
OP862_RS04530	COG0716	FMN binding
OP862_RS04535	COG4974	Belongs to the 'phage' integrase family
OP862_RS04540	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
OP862_RS04545	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
OP862_RS04565	COG0582	viral genome integration into host DNA
OP862_RS04635	COG0656	L-ascorbic acid biosynthetic process
OP862_RS04655	COG3706	GGDEF domain
OP862_RS04660	COG1522	sequence-specific DNA binding
OP862_RS04675	COG2271	Major facilitator Superfamily
OP862_RS04685	COG0484	heat shock protein binding
OP862_RS04695	COG1028	Short-chain dehydrogenase reductase Sdr
OP862_RS04700	COG1733	regulation of RNA biosynthetic process
OP862_RS04740	COG0583	DNA-binding transcription factor activity
OP862_RS04745	COG2814	Major facilitator Superfamily
OP862_RS04750	COG0583	DNA-binding transcription factor activity
OP862_RS04760	COG1609	Transcriptional regulator
OP862_RS04770	COG0204	Acyl-transferase
OP862_RS04770	COG0318	PFAM AMP-dependent synthetase and ligase
OP862_RS04775	COG0477	Major facilitator Superfamily
OP862_RS04780	COG5499	transcription regulator containing HTH domain
OP862_RS04785	COG0667	Aldo Keto reductase
OP862_RS04790	COG0861	Integral membrane protein TerC family
OP862_RS04795	COG3066	DNA modification
OP862_RS04800	COG1051	belongs to the nudix hydrolase family
OP862_RS04810	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
OP862_RS04820	COG2165	general secretion pathway protein
OP862_RS04840	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
OP862_RS04845	COG1025	Belongs to the peptidase M16 family
OP862_RS04850	COG1074	ATP-dependent DNA helicase activity
OP862_RS04855	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
OP862_RS04860	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
OP862_RS04860	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
OP862_RS04865	COG0860	N-Acetylmuramoyl-L-alanine amidase
OP862_RS04880	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
OP862_RS04885	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
OP862_RS04890	COG2166	iron-sulfur cluster assembly
OP862_RS04895	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
OP862_RS04905	COG0583	DNA-binding transcription factor activity
OP862_RS04910	COG2363	Small membrane protein
OP862_RS04915	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
OP862_RS04925	COG1611	Belongs to the LOG family
OP862_RS04930	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
OP862_RS04930	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
OP862_RS04940	COG3098	single-species biofilm formation
OP862_RS04945	COG0564	pseudouridine synthase activity
OP862_RS04970	COG2171	N-acyltransferase activity
OP862_RS04975	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
OP862_RS04990	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
OP862_RS04995	COG0528	UMP kinase activity
OP862_RS05005	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
OP862_RS05015	COG0575	Belongs to the CDS family
OP862_RS05020	COG0750	zinc metalloprotease
OP862_RS05030	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
OP862_RS05035	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
OP862_RS05045	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
OP862_RS05055	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
OP862_RS05060	COG0587	DNA-directed DNA polymerase activity
OP862_RS05065	COG0825	malonyl-CoA metabolic process
OP862_RS05070	COG0346	lactoylglutathione lyase activity
OP862_RS05085	COG4568	rho-dependent transcription termination
OP862_RS05095	COG4681	YaeQ
OP862_RS05105	COG3015	lipoprotein NlpE involved in copper resistance
OP862_RS05110	COG0442	prolyl-tRNA aminoacylation
OP862_RS05115	COG1720	tRNA m6t6A37 methyltransferase activity
OP862_RS05125	COG1464	Belongs to the NlpA lipoprotein family
OP862_RS05130	COG2011	ABC-type metal ion transport system permease component
OP862_RS05140	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
OP862_RS05170	COG2814	Major facilitator Superfamily
OP862_RS05175	COG0583	DNA-binding transcription factor activity
OP862_RS05180	COG0656	L-ascorbic acid biosynthetic process
OP862_RS05185	COG3021	interspecies interaction between organisms
OP862_RS05190	COG0741	lytic transglycosylase activity
OP862_RS05190	COG1388	LysM domain
OP862_RS05195	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
OP862_RS05200	COG2226	methyltransferase
OP862_RS05210	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
OP862_RS05220	COG2113	Glycine betaine
OP862_RS05225	COG4176	ABC-type proline glycine betaine transport system permease component
OP862_RS05235	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
OP862_RS05245	COG1780	Probably involved in ribonucleotide reductase function
OP862_RS05255	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
OP862_RS05265	COG4575	ribosome binding
OP862_RS05290	COG0747	negative chemotaxis
OP862_RS05300	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
OP862_RS05305	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
OP862_RS05320	COG0831	urea catabolic process
OP862_RS05325	COG0832	Belongs to the urease beta subunit family
OP862_RS05330	COG0804	urea catabolic process
OP862_RS05335	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
OP862_RS05345	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
OP862_RS05355	COG4413	Urea transporter
OP862_RS05360	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
OP862_RS05370	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
OP862_RS05385	COG2133	pyrroloquinoline quinone binding
OP862_RS05395	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
OP862_RS05400	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
OP862_RS05405	COG1447	Phosphotransferase system cellobiose-specific component IIA
OP862_RS05410	COG1917	Cupin 2, conserved barrel domain protein
OP862_RS05410	COG2169	Transcriptional regulator
OP862_RS05415	COG3394	polysaccharide catabolic process
OP862_RS05425	COG1595	DNA-templated transcription, initiation
OP862_RS05430	COG3712	iron ion homeostasis
OP862_RS05435	COG4772	TonB-dependent receptor
OP862_RS05440	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
OP862_RS05445	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
OP862_RS05450	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
OP862_RS05455	COG1120	ATPase activity
OP862_RS05560	COG1393	Belongs to the ArsC family
OP862_RS05565	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
OP862_RS05590	COG0288	reversible hydration of carbon dioxide
OP862_RS05630	COG0582	viral genome integration into host DNA
OP862_RS05640	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
OP862_RS05645	COG2867	negative regulation of translational initiation
OP862_RS05655	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
OP862_RS05660	COG0497	DNA recombination
OP862_RS05665	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
OP862_RS05670	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
OP862_RS05675	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
OP862_RS05680	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
OP862_RS05685	COG0513	Belongs to the DEAD box helicase family
OP862_RS05690	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
OP862_RS05695	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
OP862_RS05710	COG3026	antisigma factor binding
OP862_RS05715	COG3086	response to oxidative stress
OP862_RS05745	COG1381	Involved in DNA repair and RecF pathway recombination
OP862_RS05750	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
OP862_RS05755	COG0736	holo-[acyl-carrier-protein] synthase activity
OP862_RS05760	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
OP862_RS05765	COG1737	Transcriptional regulator
OP862_RS05770	COG0560	Phosphoserine phosphatase
OP862_RS05780	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
OP862_RS05795	COG2205	protein histidine kinase activity
OP862_RS05800	COG3170	Tfp pilus assembly protein FimV
OP862_RS05805	COG2204	response regulator
OP862_RS05810	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
OP862_RS05810	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
OP862_RS05815	COG0347	Belongs to the P(II) protein family
OP862_RS05830	COG1735	metal-dependent hydrolase with the TIM-barrel fold
OP862_RS05835	COG3457	Alanine racemase
OP862_RS05845	COG2188	Transcriptional regulator
OP862_RS05850	COG1017	nitric oxide dioxygenase activity
OP862_RS05850	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
OP862_RS05860	COG2814	Major facilitator Superfamily
OP862_RS05865	COG3711	transcriptional antiterminator
OP862_RS05870	COG3683	transport system, periplasmic component
OP862_RS05875	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
OP862_RS05880	COG0483	inositol monophosphate 1-phosphatase activity
OP862_RS05885	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
OP862_RS05890	COG1959	2 iron, 2 sulfur cluster binding
OP862_RS05900	COG0822	iron-sulfur transferase activity
OP862_RS05910	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
OP862_RS05915	COG0443	Heat shock 70 kDa protein
OP862_RS05920	COG0633	Ferredoxin
OP862_RS05925	COG2975	iron-sulfur cluster assembly
OP862_RS05940	COG3468	outer membrane autotransporter barrel domain protein
OP862_RS05945	COG2373	Large extracellular alpha-helical protein
OP862_RS05950	COG4953	penicillin-binding protein 1C
OP862_RS05975	COG1426	Protein conserved in bacteria
OP862_RS05990	COG2976	Protein conserved in bacteria
OP862_RS05995	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
OP862_RS06000	COG1160	GTP binding
OP862_RS06010	COG1645	bacterial-type flagellum-dependent swarming motility
OP862_RS06015	COG1570	exodeoxyribonuclease VII activity
OP862_RS06020	COG0516	GMP reductase activity
OP862_RS06020	COG0517	IMP dehydrogenase activity
OP862_RS06025	COG0518	GMP synthase (glutamine-hydrolyzing) activity
OP862_RS06025	COG0519	Catalyzes the synthesis of GMP from XMP
OP862_RS06035	COG3710	Transcriptional regulator
OP862_RS06045	COG2197	response regulator
OP862_RS06060	COG3121	Chaperone
OP862_RS06070	COG3121	Chaperone
OP862_RS06075	COG3121	Chaperone
OP862_RS06090	COG0351	phosphomethylpyrimidine kinase
OP862_RS06110	COG1349	DNA-binding transcription factor activity
OP862_RS06115	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
OP862_RS06120	COG1028	Short-chain dehydrogenase reductase Sdr
OP862_RS06135	COG3730	PTS system glucitol sorbitol-specific
OP862_RS06140	COG1597	lipid kinase activity
OP862_RS06145	COG0826	peptidase U32
OP862_RS06150	COG3422	double-strand break repair
OP862_RS06155	COG0745	RESPONSE REGULATOR receiver
OP862_RS06160	COG2205	protein histidine kinase activity
OP862_RS06165	COG0477	Major facilitator Superfamily
OP862_RS06170	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
OP862_RS06180	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
OP862_RS06195	COG3121	Chaperone
OP862_RS06205	COG0443	Heat shock 70 kDa protein
OP862_RS06210	COG5002	protein histidine kinase activity
OP862_RS06210	COG5001	Diguanylate cyclase
OP862_RS06210	COG3447	MASE1 domain protein
OP862_RS06215	COG2239	Acts as a magnesium transporter
OP862_RS06230	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
OP862_RS06240	COG0581	inorganic phosphate transmembrane transporter activity
OP862_RS06250	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
OP862_RS06255	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
OP862_RS06265	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
OP862_RS06270	COG2233	PERMEase
OP862_RS06275	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
OP862_RS06280	COG1393	Belongs to the ArsC family
OP862_RS06285	COG4783	chaperone-mediated protein folding
OP862_RS06290	COG0628	permease
OP862_RS06295	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
OP862_RS06300	COG2716	regulation of RNA biosynthetic process
OP862_RS06305	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
OP862_RS06310	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
OP862_RS06315	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
OP862_RS06320	COG2321	neutral zinc metallopeptidase
OP862_RS06325	COG2707	UPF0756 membrane protein
OP862_RS06330	COG1444	tRNA N-acetyltransferase activity
OP862_RS06335	COG0400	carboxylic ester hydrolase activity
OP862_RS06345	COG1876	peptidase activity
OP862_RS06350	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
OP862_RS06355	COG1393	Belongs to the ArsC family
OP862_RS06360	COG0583	DNA-binding transcription factor activity
OP862_RS06365	COG2197	response regulator
OP862_RS06380	COG1175	transmembrane transport
OP862_RS06385	COG3842	ATPase activity
OP862_RS06390	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
OP862_RS06400	COG2197	response regulator
OP862_RS06405	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
OP862_RS06405	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
OP862_RS06410	COG3062	negative regulation of establishment of protein localization
OP862_RS06415	COG0243	molybdopterin cofactor binding
OP862_RS06420	COG3043	anaerobic respiration
OP862_RS06425	COG3005	denitrification pathway
OP862_RS06430	COG0494	nUDIX hydrolase
OP862_RS06445	COG0408	coproporphyrinogen oxidase activity
OP862_RS06450	COG0456	acetyltransferase
OP862_RS06470	COG1129	ABC transporter
OP862_RS06475	COG1172	Belongs to the binding-protein-dependent transport system permease family
OP862_RS06500	COG1028	Short-chain dehydrogenase reductase Sdr
OP862_RS06505	COG3111	PFAM Bacterial OB fold (BOF) protein
OP862_RS06515	COG2837	iron assimilation
OP862_RS06520	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
OP862_RS06535	COG2731	YhcH YjgK YiaL family protein
OP862_RS06540	COG1737	Transcriptional regulator
OP862_RS06555	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
OP862_RS06560	COG4208	sulfate ABC transporter
OP862_RS06595	COG1216	Glycosyl transferase, family 2
OP862_RS06625	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
OP862_RS06630	COG0745	RESPONSE REGULATOR receiver
OP862_RS06635	COG2205	protein histidine kinase activity
OP862_RS06650	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
OP862_RS06660	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
OP862_RS06670	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
OP862_RS06675	COG3530	Putative quorum-sensing-regulated virulence factor
OP862_RS06700	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
OP862_RS06735	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
OP862_RS06745	COG1914	H( )-stimulated, divalent metal cation uptake system
OP862_RS06755	COG0667	Aldo Keto reductase
OP862_RS06760	COG3961	Belongs to the TPP enzyme family
OP862_RS06775	COG0837	glucose binding
OP862_RS06780	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
OP862_RS06790	COG2223	nitrite transmembrane transporter activity
OP862_RS06795	COG3279	Response regulator of the LytR AlgR family
OP862_RS06800	COG3275	phosphorelay sensor kinase activity
OP862_RS06815	COG0436	Aminotransferase
OP862_RS06820	COG3038	cytochrome b561
OP862_RS06830	COG1598	PFAM Uncharacterised protein family UPF0150
OP862_RS06850	COG0406	alpha-ribazole phosphatase activity
OP862_RS06880	COG3302	dmso reductase anchor subunit
OP862_RS06885	COG0437	4 iron, 4 sulfur cluster binding
OP862_RS06890	COG0243	molybdopterin cofactor binding
OP862_RS06905	COG2951	lytic endotransglycosylase activity
OP862_RS06910	COG0531	amino acid
OP862_RS06930	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
OP862_RS06935	COG1127	ABC transporter
OP862_RS06950	COG3038	cytochrome b561
OP862_RS06955	COG2353	YceI-like domain
OP862_RS06960	COG1609	Transcriptional regulator
OP862_RS06965	COG1263	PTS System
OP862_RS06965	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
OP862_RS06970	COG2723	6-phospho-beta-galactosidase activity
OP862_RS06980	COG1695	Transcriptional regulator
OP862_RS06985	COG2824	Alkylphosphonate utilization operon protein PhnA
OP862_RS06990	COG2226	methyltransferase
OP862_RS06995	COG0076	glutamate decarboxylase activity
OP862_RS07000	COG0531	amino acid
OP862_RS07015	COG2095	MarC family integral membrane protein
OP862_RS07025	COG0784	Response regulator, receiver
OP862_RS07025	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
OP862_RS07025	COG2205	protein histidine kinase activity
OP862_RS07025	COG2198	Histidine kinase
OP862_RS07030	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
OP862_RS07030	COG0784	Response regulator, receiver
OP862_RS07030	COG2205	protein histidine kinase activity
OP862_RS07030	COG2198	Histidine kinase
OP862_RS07035	COG2197	response regulator
OP862_RS07040	COG2181	nitrate reductase activity
OP862_RS07045	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
OP862_RS07050	COG1140	nitrate reductase beta subunit
OP862_RS07055	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
OP862_RS07060	COG2223	nitrite transmembrane transporter activity
OP862_RS07065	COG2197	response regulator
OP862_RS07070	COG3005	denitrification pathway
OP862_RS07075	COG0243	molybdopterin cofactor binding
OP862_RS07085	COG2116	formate transmembrane transporter activity
OP862_RS07095	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
OP862_RS07100	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
OP862_RS07105	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
OP862_RS07110	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
OP862_RS07115	COG1138	Cytochrome C-type biogenesis protein
OP862_RS07120	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
OP862_RS07125	COG3088	subunit of a heme lyase
OP862_RS07125	COG4235	cytochrome complex assembly
OP862_RS07130	COG3088	subunit of a heme lyase
OP862_RS07130	COG4235	cytochrome complex assembly
OP862_RS07155	COG3691	Protein conserved in bacteria
OP862_RS07160	COG0183	Belongs to the thiolase family
OP862_RS07165	COG1024	Enoyl-CoA hydratase
OP862_RS07165	COG1250	3-hydroxyacyl-CoA dehydrogenase
OP862_RS07170	COG2062	phosphohistidine phosphatase, SixA
OP862_RS07180	COG2840	Smr protein MutS2
OP862_RS07185	COG2890	protein-(glutamine-N5) methyltransferase activity
OP862_RS07195	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
OP862_RS07200	COG0730	response to heat
OP862_RS07205	COG3101	peptidyl-lysine hydroxylation
OP862_RS07215	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
OP862_RS07215	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
OP862_RS07220	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
OP862_RS07230	COG1794	racemase activity, acting on amino acids and derivatives
OP862_RS07240	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
OP862_RS07260	COG4232	protein-disulfide reductase activity
OP862_RS07270	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
OP862_RS07275	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
OP862_RS07275	COG1017	nitric oxide dioxygenase activity
OP862_RS07295	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
OP862_RS07305	COG0586	Pfam SNARE associated Golgi protein
OP862_RS07310	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
OP862_RS07315	COG0285	dihydrofolate synthase activity
OP862_RS07320	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
OP862_RS07325	COG1286	toxin biosynthetic process
OP862_RS07330	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
OP862_RS07340	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
OP862_RS07345	COG4215	(ABC) transporter
OP862_RS07350	COG4160	amino acid transport
OP862_RS07355	COG4598	ABC transporter
OP862_RS07360	COG1090	epimerase
OP862_RS07370	COG0622	Phosphoesterase
OP862_RS07375	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
OP862_RS07380	COG0561	phosphatase activity
OP862_RS07385	COG2706	6-phosphogluconolactonase activity
OP862_RS07395	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
OP862_RS07400	COG0156	8-amino-7-oxononanoate synthase activity
OP862_RS07405	COG2226	methyltransferase
OP862_RS07420	COG0556	nucleotide-excision repair
OP862_RS07425	COG4628	conserved protein (DUF2132)
OP862_RS07430	COG0391	Required for morphogenesis under gluconeogenic growth conditions
OP862_RS07435	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
OP862_RS07440	COG0315	cyclic pyranopterin monophosphate synthase activity
OP862_RS07445	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
OP862_RS07450	COG0314	molybdopterin synthase activity
OP862_RS07455	COG0670	Belongs to the BI1 family
OP862_RS07460	COG4774	siderophore transport
OP862_RS07475	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
OP862_RS07485	COG4592	Periplasmic binding protein
OP862_RS07490	COG1169	isochorismate synthase
OP862_RS07495	COG1021	2,3-dihydroxybenzoate-AMP ligase
OP862_RS07500	COG3433	isochorismatase activity
OP862_RS07500	COG1535	isochorismatase
OP862_RS07505	COG1028	Short-chain dehydrogenase reductase Sdr
OP862_RS07510	COG0842	Transport permease protein
OP862_RS07515	COG0842	Transport permease protein
OP862_RS07520	COG1131	(ABC) transporter
OP862_RS07525	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
OP862_RS07530	COG1309	transcriptional regulator
OP862_RS07535	COG0513	Belongs to the DEAD box helicase family
OP862_RS07540	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
OP862_RS07550	COG1686	Belongs to the peptidase S11 family
OP862_RS07555	COG0277	FAD linked oxidase domain protein
OP862_RS07575	COG2261	transglycosylase associated protein
OP862_RS07585	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
OP862_RS07600	COG4807	Protein conserved in bacteria
OP862_RS07620	COG1122	ATPase activity
OP862_RS07630	COG2897	thiosulfate sulfurtransferase activity
OP862_RS07645	COG1732	Glycine betaine
OP862_RS07650	COG1174	glycine betaine transport
OP862_RS07655	COG1125	glycine betaine transport
OP862_RS07660	COG1174	glycine betaine transport
OP862_RS07670	COG0531	amino acid
OP862_RS07675	COG1982	Orn Lys Arg decarboxylase major
OP862_RS07685	COG0697	spore germination
OP862_RS07700	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
OP862_RS07705	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
OP862_RS07720	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
OP862_RS07725	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
OP862_RS07735	COG1126	abc transporter atp-binding protein
OP862_RS07740	COG0765	amino acid transport
OP862_RS07745	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
OP862_RS07750	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
OP862_RS07755	COG0783	Belongs to the Dps family
OP862_RS07760	COG4106	trans-aconitate 2-methyltransferase activity
OP862_RS07775	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
OP862_RS07790	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
OP862_RS07810	COG0488	(ABC) transporter
OP862_RS07820	COG0303	'Molybdopterin
OP862_RS07830	COG0477	Major facilitator Superfamily
OP862_RS07845	COG0583	DNA-binding transcription factor activity
OP862_RS07850	COG0477	Major facilitator Superfamily
OP862_RS07855	COG0302	gtp cyclohydrolase
OP862_RS07860	COG2311	Membrane
OP862_RS07890	COG3604	Transcriptional regulator
OP862_RS07895	COG3383	formate dehydrogenase (NAD+) activity
OP862_RS07900	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
OP862_RS07905	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
OP862_RS07915	COG3260	NADH ubiquinone oxidoreductase 20
OP862_RS07920	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
OP862_RS07925	COG3261	NADH dehydrogenase
OP862_RS07925	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
OP862_RS07930	COG0651	ATP synthesis coupled electron transport
OP862_RS07935	COG4237	Hydrogenase 4 membrane
OP862_RS07940	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
OP862_RS07945	COG0650	Formate hydrogenlyase subunit 4
OP862_RS07950	COG0651	ATP synthesis coupled electron transport
OP862_RS07955	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
OP862_RS07960	COG0375	protein maturation
OP862_RS07965	COG0298	carbon dioxide binding
OP862_RS07970	COG2949	membrane
OP862_RS07975	COG0281	malic enzyme
OP862_RS07985	COG1346	cytolysis
OP862_RS07990	COG1380	Effector of murein hydrolase LrgA
OP862_RS07995	COG2814	Major facilitator Superfamily
OP862_RS08010	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
OP862_RS08010	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
OP862_RS08015	COG0489	protein tyrosine kinase activity
OP862_RS08030	COG2982	Protein involved in outer membrane biogenesis
OP862_RS08035	COG3069	C4-dicarboxylate transmembrane transporter activity
OP862_RS08040	COG1253	flavin adenine dinucleotide binding
OP862_RS08065	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
OP862_RS08075	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
OP862_RS08095	COG1210	Utp--glucose-1-phosphate uridylyltransferase
OP862_RS08100	COG1210	Utp--glucose-1-phosphate uridylyltransferase
OP862_RS08105	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
OP862_RS08110	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
OP862_RS08110	COG0140	phosphoribosyl-ATP diphosphatase activity
OP862_RS08115	COG0107	imidazoleglycerol-phosphate synthase activity
OP862_RS08120	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
OP862_RS08130	COG0131	Imidazoleglycerol-phosphate dehydratase
OP862_RS08130	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
OP862_RS08135	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
OP862_RS08140	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
OP862_RS08145	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
OP862_RS08155	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
OP862_RS08160	COG1172	Belongs to the binding-protein-dependent transport system permease family
OP862_RS08165	COG1129	ABC transporter
OP862_RS08170	COG0371	Dehydrogenase
OP862_RS08175	COG0531	amino acid
OP862_RS08180	COG2925	Exonuclease
OP862_RS08190	COG1289	transmembrane transporter activity
OP862_RS08195	COG2926	Belongs to the UPF0265 family
OP862_RS08205	COG1172	Belongs to the binding-protein-dependent transport system permease family
OP862_RS08210	COG1129	ABC transporter
OP862_RS08225	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
OP862_RS08235	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
OP862_RS08255	COG4656	Part of a membrane complex involved in electron transport
OP862_RS08265	COG1012	belongs to the aldehyde dehydrogenase family
OP862_RS08275	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
OP862_RS08350	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
OP862_RS08360	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
OP862_RS08425	COG1492	cobalamin metabolic process
OP862_RS08445	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
OP862_RS08450	COG0583	DNA-binding transcription factor activity
OP862_RS08460	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
OP862_RS08465	COG2211	Major facilitator Superfamily
OP862_RS08470	COG0137	argininosuccinate synthase activity
OP862_RS08475	COG0534	Mate efflux family protein
OP862_RS08480	COG0784	Response regulator, receiver
OP862_RS08480	COG0835	chemotaxis
OP862_RS08485	COG4221	oxidoreductase activity
OP862_RS08490	COG3550	peptidyl-serine autophosphorylation
OP862_RS08495	COG3550	peptidyl-serine autophosphorylation
OP862_RS08535	COG1187	pseudouridine synthase activity
OP862_RS08540	COG3121	Chaperone
OP862_RS08555	COG3121	Chaperone
OP862_RS08565	COG2205	protein histidine kinase activity
OP862_RS08565	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
OP862_RS08580	COG3842	ATPase activity
OP862_RS08590	COG1840	ABC-type Fe3 transport system, periplasmic component
OP862_RS08595	COG2271	Major facilitator Superfamily
OP862_RS08610	COG4565	transcriptional regulatory protein
OP862_RS08615	COG3290	protein histidine kinase activity
OP862_RS08620	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
OP862_RS08625	COG3052	prosthetic group binding
OP862_RS08630	COG2301	Belongs to the HpcH HpaI aldolase family
OP862_RS08635	COG3051	citrate lyase alpha subunit
OP862_RS08645	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
OP862_RS08650	COG0471	metal ion transport
OP862_RS08670	COG0700	Nucleoside recognition
OP862_RS08675	COG3366	ferrous iron transmembrane transporter activity
OP862_RS08685	COG0471	metal ion transport
OP862_RS08690	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
OP862_RS08695	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
OP862_RS08700	COG0583	DNA-binding transcription factor activity
OP862_RS08710	COG3122	Protein conserved in bacteria
OP862_RS08790	COG0583	DNA-binding transcription factor activity
OP862_RS08795	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
OP862_RS08805	COG3228	Belongs to the MtfA family
OP862_RS08835	COG0604	alcohol dehydrogenase
OP862_RS08835	COG1028	Short-chain dehydrogenase reductase Sdr
OP862_RS08835	COG3321	synthase
OP862_RS08840	COG3250	beta-galactosidase activity
OP862_RS08845	COG1609	Transcriptional regulator
OP862_RS08860	COG0840	transmembrane signaling receptor activity
OP862_RS08865	COG1285	pathogenesis
OP862_RS08875	COG2130	NADP-dependent
OP862_RS08880	COG0589	response to stress
OP862_RS08905	COG2198	Histidine kinase
OP862_RS08905	COG0643	Histidine kinase
OP862_RS08910	COG0835	chemotaxis
OP862_RS08915	COG0840	transmembrane signaling receptor activity
OP862_RS08920	COG0840	transmembrane signaling receptor activity
OP862_RS08925	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
OP862_RS08935	COG0745	RESPONSE REGULATOR receiver
OP862_RS08940	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
OP862_RS08945	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
OP862_RS08950	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
OP862_RS08965	COG3418	PFAM FlgN family protein
OP862_RS08970	COG2747	anti-sigma28 factor FlgM
OP862_RS08980	COG1815	bacterial-type flagellum-dependent cell motility
OP862_RS08985	COG1558	bacterial-type flagellum-dependent cell motility
OP862_RS08990	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
OP862_RS09025	COG1256	bacterial-type flagellum assembly
OP862_RS09045	COG1338	Plays a role in the flagellum-specific transport system
OP862_RS09080	COG1157	protein secretion by the type III secretion system
OP862_RS09085	COG1317	bacterial-type flagellum organization
OP862_RS09100	COG1677	Flagellar hook-basal body complex protein FliE
OP862_RS09105	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
OP862_RS09110	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
OP862_RS09145	COG1191	sigma factor activity
OP862_RS09155	COG2515	1-aminocyclopropane-1-carboxylate deaminase
OP862_RS09160	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
OP862_RS09165	COG0765	amino acid transport
OP862_RS09170	COG1126	abc transporter atp-binding protein
OP862_RS09185	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
OP862_RS09185	COG0506	proline dehydrogenase activity
OP862_RS09185	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
OP862_RS09195	COG0672	)-iron permease
OP862_RS09200	COG2822	iron ion transport
OP862_RS09220	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
OP862_RS09225	COG2233	PERMEase
OP862_RS09230	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
OP862_RS09235	COG0778	Nitroreductase
OP862_RS09240	COG2267	carboxylic ester hydrolase activity
OP862_RS09245	COG0251	oxidation-reduction process
OP862_RS09250	COG1335	isochorismatase
OP862_RS09255	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
OP862_RS09260	COG1309	transcriptional regulator
OP862_RS09265	COG1113	amino acid transport
OP862_RS09330	COG2264	protein methyltransferase activity
OP862_RS09345	COG0366	Alpha amylase catalytic
OP862_RS09355	COG3136	membrane protein required for alginate biosynthesis
OP862_RS09365	COG2197	response regulator
OP862_RS09370	COG0322	excinuclease ABC activity
OP862_RS09375	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
OP862_RS09425	COG3069	C4-dicarboxylate transmembrane transporter activity
OP862_RS09430	COG1737	Transcriptional regulator
OP862_RS09435	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
OP862_RS09465	COG0840	transmembrane signaling receptor activity
OP862_RS09475	COG2873	o-acetylhomoserine
OP862_RS09480	COG0702	epimerase
OP862_RS09485	COG1733	regulation of RNA biosynthetic process
OP862_RS09500	COG0246	Mannitol dehydrogenase
OP862_RS09505	COG1063	alcohol dehydrogenase
OP862_RS09510	COG1802	Transcriptional regulator
OP862_RS09515	COG2271	Major facilitator Superfamily
OP862_RS09545	COG2203	Gaf domain
OP862_RS09545	COG3706	GGDEF domain
OP862_RS09545	COG4251	negative regulation of phosphorylation
OP862_RS09545	COG5001	Diguanylate cyclase
OP862_RS09555	COG1132	(ABC) transporter
OP862_RS09570	COG2207	Transcriptional regulator
OP862_RS09605	COG1113	amino acid transport
OP862_RS09625	COG1496	oxidoreductase activity
OP862_RS09630	COG0768	penicillin binding
OP862_RS09635	COG2226	methyltransferase
OP862_RS09645	COG5002	protein histidine kinase activity
OP862_RS09645	COG5001	Diguanylate cyclase
OP862_RS09645	COG3447	MASE1 domain protein
OP862_RS09655	COG1971	Probably functions as a manganese efflux pump
OP862_RS09665	COG3716	PTS system mannose fructose sorbose family IID component
OP862_RS09670	COG3715	PTS system
OP862_RS09675	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
OP862_RS09675	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
OP862_RS09680	COG1253	flavin adenine dinucleotide binding
OP862_RS09690	COG1760	l-serine dehydratase
OP862_RS09695	COG0494	nUDIX hydrolase
OP862_RS09705	COG3140	Belongs to the UPF0181 family
OP862_RS09710	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
OP862_RS09715	COG0513	Belongs to the DEAD box helicase family
OP862_RS09720	COG3141	response to X-ray
OP862_RS09725	COG3097	Belongs to the UPF0267 family
OP862_RS09735	COG1770	oligopeptidase
OP862_RS09740	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
OP862_RS09760	COG1528	Iron-storage protein
OP862_RS09765	COG2372	response to copper ion
OP862_RS09770	COG1276	copper resistance
OP862_RS09920	COG1674	ftsk spoiiie
OP862_RS09920	COG1178	ABC-type Fe3 transport system permease component
OP862_RS09930	COG4725	Belongs to the MT-A70-like family
OP862_RS09965	COG3772	lysozyme
OP862_RS10090	COG3646	Phage regulatory protein
OP862_RS10120	COG0346	lactoylglutathione lyase activity
OP862_RS10155	COG0625	glutathione transferase activity
OP862_RS10185	COG5001	Diguanylate cyclase
OP862_RS10185	COG4251	negative regulation of phosphorylation
OP862_RS10185	COG3706	GGDEF domain
OP862_RS10185	COG2203	Gaf domain
OP862_RS10220	COG2814	Major facilitator Superfamily
OP862_RS10230	COG3008	intermembrane lipid transfer
OP862_RS10235	COG2995	paraquat-inducible protein a
OP862_RS10240	COG1956	GAF domain-containing protein
OP862_RS10245	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
OP862_RS10250	COG0793	Belongs to the peptidase S41A family
OP862_RS10255	COG0501	Belongs to the peptidase M48B family
OP862_RS10260	COG2814	Major facilitator Superfamily
OP862_RS10265	COG0823	Involved in the tonB-independent uptake of proteins
OP862_RS10275	COG3023	N-Acetylmuramoyl-L-alanine amidase
OP862_RS10280	COG1823	symporter activity
OP862_RS10285	COG1988	membrane-bound metal-dependent
OP862_RS10290	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
OP862_RS10300	COG3842	ATPase activity
OP862_RS10305	COG0395	ABC-type sugar transport system, permease component
OP862_RS10310	COG1175	transmembrane transport
OP862_RS10320	COG1028	Short-chain dehydrogenase reductase Sdr
OP862_RS10325	COG1917	Cupin 2, conserved barrel domain protein
OP862_RS10330	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
OP862_RS10340	COG3001	Fructosamine kinase
OP862_RS10345	COG1108	ABC-type Mn2 Zn2 transport systems permease components
OP862_RS10350	COG1108	ABC-type Mn2 Zn2 transport systems permease components
OP862_RS10355	COG1121	(ABC) transporter
OP862_RS10360	COG0803	Belongs to the bacterial solute-binding protein 9 family
OP862_RS10385	COG3623	hexulose-6-phosphate isomerase
OP862_RS10390	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
OP862_RS10395	COG1070	Carbohydrate kinase
OP862_RS10415	COG1172	Belongs to the binding-protein-dependent transport system permease family
OP862_RS10420	COG1129	ABC transporter
OP862_RS10425	COG1414	Transcriptional regulator
OP862_RS10430	COG1811	Na channel or pump
OP862_RS10435	COG4249	Peptidase C14 caspase catalytic subunit p20
OP862_RS10475	COG0776	regulation of translation
OP862_RS10480	COG2719	SpoVR family
OP862_RS10485	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
OP862_RS10490	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
OP862_RS10495	COG0642	Histidine kinase
OP862_RS10505	COG3111	PFAM Bacterial OB fold (BOF) protein
OP862_RS10510	COG2814	Major facilitator Superfamily
OP862_RS10515	COG2199	diguanylate cyclase activity
OP862_RS10515	COG2200	EAL domain
OP862_RS10515	COG2202	Pas domain
OP862_RS10525	COG0583	DNA-binding transcription factor activity
OP862_RS10535	COG2718	Belongs to the UPF0229 family
OP862_RS10540	COG2766	serine protein kinase
OP862_RS10545	COG3713	MltA-interacting MipA family protein
OP862_RS10575	COG3139	Protein of unknown function (DUF1315)
OP862_RS10580	COG1335	isochorismatase
OP862_RS10585	COG0252	asparaginase activity
OP862_RS10590	COG0616	signal peptide processing
OP862_RS10595	COG0778	Nitroreductase
OP862_RS10605	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
OP862_RS10615	COG0494	nUDIX hydrolase
OP862_RS10620	COG0708	Exodeoxyribonuclease III
OP862_RS10625	COG0583	DNA-binding transcription factor activity
OP862_RS10645	COG0788	formyltetrahydrofolate deformylase activity
OP862_RS10650	COG3012	SEC-C Motif Domain Protein
OP862_RS10660	COG1752	Esterase of the alpha-beta hydrolase superfamily
OP862_RS10665	COG0745	RESPONSE REGULATOR receiver
OP862_RS10675	COG2916	Histone family protein nucleoid-structuring protein H-NS
OP862_RS10685	COG1012	belongs to the aldehyde dehydrogenase family
OP862_RS10685	COG1454	alcohol dehydrogenase
OP862_RS10690	COG2095	MarC family integral membrane protein
OP862_RS10695	COG4166	transmembrane transport
OP862_RS10710	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
OP862_RS10715	COG0444	Belongs to the ABC transporter superfamily
OP862_RS10720	COG4608	Belongs to the ABC transporter superfamily
OP862_RS10725	COG3099	Belongs to the UPF0263 family
OP862_RS10730	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
OP862_RS10740	COG2200	EAL domain
OP862_RS10750	COG2350	Protein conserved in bacteria
OP862_RS10755	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
OP862_RS10765	COG2917	probably involved in intracellular septation
OP862_RS10780	COG3047	cAMP biosynthetic process
OP862_RS10790	COG0159	tryptophan synthase activity
OP862_RS10795	COG0133	tryptophan synthase activity
OP862_RS10800	COG0134	indole-3-glycerol-phosphate synthase activity
OP862_RS10800	COG0135	phosphoribosylanthranilate isomerase activity
OP862_RS10820	COG0613	PHP domain protein
OP862_RS10825	COG0009	L-threonylcarbamoyladenylate synthase
OP862_RS10835	COG2197	response regulator
OP862_RS10845	COG1187	pseudouridine synthase activity
OP862_RS10855	COG1028	Short-chain dehydrogenase reductase Sdr
OP862_RS10860	COG0616	signal peptide processing
OP862_RS10875	COG0583	DNA-binding transcription factor activity
OP862_RS10885	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
OP862_RS10895	COG0671	phosphoesterase, PA-phosphatase related
OP862_RS10900	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
OP862_RS10905	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
OP862_RS10920	COG0284	orotidine-5'-phosphate decarboxylase activity
OP862_RS10925	COG0023	Translation Initiation Factor
OP862_RS10935	COG0235	Class ii aldolase
OP862_RS10945	COG1349	DNA-binding transcription factor activity
OP862_RS10960	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
OP862_RS10965	COG2879	small protein
OP862_RS10970	COG1966	Carbon starvation protein
OP862_RS10975	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
OP862_RS10980	COG0243	molybdopterin cofactor binding
OP862_RS10985	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
OP862_RS10995	COG4659	FMN binding
OP862_RS11005	COG2207	Transcriptional regulator
OP862_RS11005	COG3708	Transcriptional regulator
OP862_RS11020	COG4657	Part of a membrane complex involved in electron transport
OP862_RS11030	COG2759	Belongs to the formate--tetrahydrofolate ligase family
OP862_RS11035	COG2274	protein secretion by the type I secretion system
OP862_RS11045	COG2274	protein secretion by the type I secretion system
OP862_RS11050	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
OP862_RS11065	COG1879	ABC-type sugar transport system periplasmic component
OP862_RS11070	COG1129	ABC transporter
OP862_RS11075	COG1172	Belongs to the binding-protein-dependent transport system permease family
OP862_RS11085	COG0673	inositol 2-dehydrogenase activity
OP862_RS11090	COG0385	Bile acid
OP862_RS11095	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
OP862_RS11100	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
OP862_RS11105	COG1263	PTS System
OP862_RS11105	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
OP862_RS11110	COG1609	Transcriptional regulator
OP862_RS11130	COG5339	Protein conserved in bacteria
OP862_RS11140	COG0114	fumarate hydratase activity
OP862_RS11155	COG2814	Major facilitator Superfamily
OP862_RS11160	COG0583	DNA-binding transcription factor activity
OP862_RS11165	COG1940	carbohydrate kinase activity
OP862_RS11170	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
OP862_RS11190	COG1742	UPF0060 membrane protein
OP862_RS11195	COG4221	oxidoreductase activity
OP862_RS11200	COG0477	Major facilitator Superfamily
OP862_RS11240	COG0625	glutathione transferase activity
OP862_RS11250	COG1522	sequence-specific DNA binding
OP862_RS11280	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
OP862_RS11305	COG0076	glutamate decarboxylase activity
OP862_RS11310	COG0531	amino acid
OP862_RS11320	COG1011	Hydrolase
OP862_RS11345	COG1028	Short-chain dehydrogenase reductase Sdr
OP862_RS11355	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
OP862_RS11370	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
OP862_RS11375	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
OP862_RS11380	COG0589	response to stress
OP862_RS11385	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
OP862_RS11390	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
OP862_RS11400	COG0531	amino acid
OP862_RS11410	COG0745	RESPONSE REGULATOR receiver
OP862_RS11415	COG2205	protein histidine kinase activity
OP862_RS11420	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
OP862_RS11430	COG3591	Belongs to the peptidase S1B family
OP862_RS11440	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
OP862_RS11445	COG1643	Atp-dependent helicase
OP862_RS11450	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
OP862_RS11455	COG0477	Major facilitator Superfamily
OP862_RS11465	COG3423	Transcriptional regulator
OP862_RS11475	COG0246	Mannitol dehydrogenase
OP862_RS11480	COG1070	Carbohydrate kinase
OP862_RS11490	COG3784	Protein of unknown function (DUF1318)
OP862_RS11500	COG2911	Protein conserved in bacteria
OP862_RS11505	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
OP862_RS11510	COG3042	response to heat
OP862_RS11520	COG0674	pyruvate-flavodoxin oxidoreductase activity
OP862_RS11520	COG1013	pyruvate-flavodoxin oxidoreductase activity
OP862_RS11520	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
OP862_RS11520	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
OP862_RS11525	COG2723	6-phospho-beta-galactosidase activity
OP862_RS11530	COG2190	(PTS) system
OP862_RS11530	COG1263	PTS System
OP862_RS11530	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
OP862_RS11535	COG3711	transcriptional antiterminator
OP862_RS11540	COG0037	tRNA processing
OP862_RS11550	COG4166	transmembrane transport
OP862_RS11555	COG2866	Carboxypeptidase
OP862_RS11560	COG4948	Mandelate Racemase Muconate Lactonizing
OP862_RS11565	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
OP862_RS11575	COG5642	Protein of unknown function (DUF2384)
OP862_RS11580	COG5654	RES domain protein
OP862_RS11585	COG3768	UPF0283 membrane protein
OP862_RS11590	COG3106	COG3106 Predicted ATPase
OP862_RS11600	COG1983	PspC domain protein
OP862_RS11610	COG1842	Phage shock protein A
OP862_RS11615	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
OP862_RS11620	COG4166	transmembrane transport
OP862_RS11630	COG4171	peptide transport system, permease
OP862_RS11640	COG4172	Belongs to the ABC transporter superfamily
OP862_RS11645	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
OP862_RS11645	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
OP862_RS11650	COG3104	oligopeptide transport
OP862_RS11655	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
OP862_RS11675	COG0625	glutathione transferase activity
OP862_RS11685	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
OP862_RS11695	COG3895	Periplasmic Protein
OP862_RS11700	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
OP862_RS11705	COG3133	Outer membrane lipoprotein
OP862_RS11710	COG1846	Transcriptional regulator
OP862_RS11720	COG1566	PFAM secretion protein HlyD family protein
OP862_RS11730	COG4989	oxidoreductase activity
OP862_RS11735	COG3313	Fe-S protein
OP862_RS11740	COG2194	sulfuric ester hydrolase activity
OP862_RS11745	COG1309	transcriptional regulator
OP862_RS11750	COG1902	pentaerythritol trinitrate reductase activity
OP862_RS11755	COG0346	lactoylglutathione lyase activity
OP862_RS11760	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
OP862_RS11765	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
OP862_RS11770	COG0791	NLP P60 protein
OP862_RS11785	COG1609	Transcriptional regulator
OP862_RS11790	COG0583	DNA-binding transcription factor activity
OP862_RS11795	COG2814	Major facilitator Superfamily
OP862_RS11800	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
OP862_RS11805	COG0307	riboflavin synthase, alpha
OP862_RS11810	COG0534	Mate efflux family protein
OP862_RS11840	COG1376	ErfK ybiS ycfS ynhG family protein
OP862_RS11840	COG1388	LysM domain
OP862_RS11845	COG2166	iron-sulfur cluster assembly
OP862_RS11855	COG0719	Fe-S assembly protein
OP862_RS11860	COG0396	ATPase activity
OP862_RS11865	COG0719	Fe-S assembly protein
OP862_RS11870	COG0316	Belongs to the HesB IscA family
OP862_RS11875	COG2050	protein possibly involved in aromatic compounds catabolism
OP862_RS11880	COG0247	lactate metabolic process
OP862_RS11880	COG0277	FAD linked oxidase domain protein
OP862_RS11885	COG0628	permease
OP862_RS11895	COG0574	Belongs to the PEP-utilizing enzyme family
OP862_RS11895	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
OP862_RS11900	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
OP862_RS11915	COG0095	Lipoate-protein ligase
OP862_RS11920	COG0791	NLP P60 protein
OP862_RS11925	COG2076	Multidrug Resistance protein
OP862_RS11935	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
OP862_RS11940	COG0726	polysaccharide deacetylase
OP862_RS11950	COG0463	Glycosyl transferase, family 2
OP862_RS11955	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
OP862_RS11960	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
OP862_RS11965	COG0386	Belongs to the glutathione peroxidase family
OP862_RS11970	COG4139	cobalamin transport
OP862_RS11980	COG0791	NLP P60 protein
OP862_RS11985	COG2186	Transcriptional regulator
OP862_RS11990	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
OP862_RS11995	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
OP862_RS12005	COG2983	Belongs to the UPF0260 family
OP862_RS12010	COG0179	Fumarylacetoacetate (FAA) hydrolase
OP862_RS12015	COG3100	YcgL domain-containing protein
OP862_RS12020	COG0850	regulation of cytokinetic process
OP862_RS12025	COG2894	cell division
OP862_RS12030	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
OP862_RS12035	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
OP862_RS12040	COG0318	PFAM AMP-dependent synthetase and ligase
OP862_RS12045	COG3065	identical protein binding
OP862_RS12055	COG1199	ATP-dependent helicase activity
OP862_RS12060	COG0251	oxidation-reduction process
OP862_RS12065	COG2076	Multidrug Resistance protein
OP862_RS12070	COG2076	Multidrug Resistance protein
OP862_RS12075	COG3397	chitin binding
OP862_RS12080	COG0800	Aldolase
OP862_RS12085	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
OP862_RS12090	COG1737	Transcriptional regulator
OP862_RS12095	COG0469	pyruvate kinase activity
OP862_RS12100	COG1560	Kdo2-lipid A biosynthetic process
OP862_RS12105	COG0739	heme binding
OP862_RS12110	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
OP862_RS12115	COG1121	(ABC) transporter
OP862_RS12120	COG1108	ABC-type Mn2 Zn2 transport systems permease components
OP862_RS12125	COG2255	four-way junction helicase activity
OP862_RS12130	COG0632	four-way junction helicase activity
OP862_RS12140	COG0217	transcriptional regulatory protein
OP862_RS12145	COG0494	nUDIX hydrolase
OP862_RS12150	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
OP862_RS12155	COG1335	isochorismatase
OP862_RS12160	COG1801	Protein of unknown function DUF72
OP862_RS12165	COG3788	relative of glutathione S-transferase, MAPEG superfamily
OP862_RS12175	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
OP862_RS12180	COG3142	Participates in the control of copper homeostasis
OP862_RS12185	COG3102	Protein conserved in bacteria
OP862_RS12195	COG0728	peptidoglycan biosynthetic process
OP862_RS12200	COG0673	inositol 2-dehydrogenase activity
OP862_RS12210	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
OP862_RS12215	COG0477	Major facilitator Superfamily
OP862_RS12225	COG3381	protein complex oligomerization
OP862_RS12235	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
OP862_RS12250	COG3706	GGDEF domain
OP862_RS12255	COG0659	secondary active sulfate transmembrane transporter activity
OP862_RS12275	COG2890	protein-(glutamine-N5) methyltransferase activity
OP862_RS12280	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
OP862_RS12285	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
OP862_RS12290	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
OP862_RS12300	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
OP862_RS12310	COG0193	aminoacyl-tRNA hydrolase activity
OP862_RS12320	COG0012	GTP binding
OP862_RS12330	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
OP862_RS12385	COG0786	glutamate:sodium symporter activity
OP862_RS12390	COG0288	reversible hydration of carbon dioxide
OP862_RS12395	COG1073	alpha beta
OP862_RS12420	COG0667	Aldo Keto reductase
OP862_RS12425	COG0318	PFAM AMP-dependent synthetase and ligase
OP862_RS12430	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
OP862_RS12435	COG0644	oxidoreductase
OP862_RS12440	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
OP862_RS12445	COG2086	electron transfer activity
OP862_RS12450	COG1917	Cupin 2, conserved barrel domain protein
OP862_RS12450	COG2207	Transcriptional regulator
OP862_RS12455	COG1960	acyl-CoA dehydrogenase activity
OP862_RS12460	COG4670	ketone body catabolic process
OP862_RS12475	COG2271	Major facilitator Superfamily
OP862_RS12480	COG0583	DNA-binding transcription factor activity
OP862_RS12485	COG0738	Major facilitator superfamily
OP862_RS12495	COG4942	peptidase
OP862_RS12505	COG3443	Belongs to the bacterial solute-binding protein 9 family
OP862_RS12510	COG4211	Belongs to the binding-protein-dependent transport system permease family
OP862_RS12515	COG1129	ABC transporter
OP862_RS12530	COG0402	S-adenosylhomocysteine deaminase activity
OP862_RS12540	COG1228	amidohydrolase
OP862_RS12555	COG2988	succinylglutamate desuccinylase activity
OP862_RS12560	COG3724	N-succinylarginine dihydrolase activity
OP862_RS12570	COG3138	arginine N-succinyltransferase
OP862_RS12575	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
OP862_RS12580	COG3866	Pectate lyase
OP862_RS12585	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
OP862_RS12590	COG1271	oxidase subunit
OP862_RS12595	COG1294	oxidase, subunit
OP862_RS12605	COG3850	Histidine kinase
OP862_RS12620	COG0387	Pfam Sodium calcium exchanger
OP862_RS12625	COG1702	phosphate starvation-inducible protein PhoH
OP862_RS12635	COG3658	cytochrome
OP862_RS12640	COG1215	transferase activity, transferring glycosyl groups
OP862_RS12645	COG1649	PFAM Uncharacterised BCR, COG1649
OP862_RS12645	COG0726	polysaccharide deacetylase
OP862_RS12650	COG0457	Tetratricopeptide repeat
OP862_RS12655	COG0006	proline dipeptidase activity
OP862_RS12685	COG0577	efflux transmembrane transporter activity
OP862_RS12685	COG1136	(ABC) transporter
OP862_RS12695	COG1136	(ABC) transporter
OP862_RS12695	COG0577	efflux transmembrane transporter activity
OP862_RS12710	COG0672	)-iron permease
OP862_RS12720	COG1447	Phosphotransferase system cellobiose-specific component IIA
OP862_RS12725	COG2723	6-phospho-beta-galactosidase activity
OP862_RS12730	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
OP862_RS12730	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
OP862_RS12735	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
OP862_RS12740	COG1609	Transcriptional regulator
OP862_RS12755	COG2066	Belongs to the glutaminase family
OP862_RS12760	COG3290	protein histidine kinase activity
OP862_RS12765	COG4565	transcriptional regulatory protein
OP862_RS12770	COG3493	citrate carrier protein
OP862_RS12780	COG3189	MarR family transcriptional regulator
OP862_RS12790	COG2223	nitrite transmembrane transporter activity
OP862_RS12795	COG0561	phosphatase activity
OP862_RS12815	COG0538	isocitrate dehydrogenase activity
OP862_RS12820	COG1187	pseudouridine synthase activity
OP862_RS12830	COG0482	sulfurtransferase activity
OP862_RS12835	COG2915	High frequency lysogenization protein hflD homolog
OP862_RS12840	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
OP862_RS12850	COG0745	RESPONSE REGULATOR receiver
OP862_RS12855	COG2205	protein histidine kinase activity
OP862_RS12860	COG2850	peptidyl-arginine hydroxylation
OP862_RS12875	COG1940	carbohydrate kinase activity
OP862_RS12880	COG4591	ABC-type transport system involved in lipoprotein release permease component
OP862_RS12890	COG4591	ABC-type transport system involved in lipoprotein release permease component
OP862_RS12895	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
OP862_RS12900	COG3134	Outer membrane lipoprotein
OP862_RS12905	COG1252	NADH dehydrogenase
OP862_RS12910	COG3150	esterase
OP862_RS12925	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
OP862_RS12930	COG5633	Lipoprotein
OP862_RS12935	COG0537	adenosine 5'-monophosphoramidase activity
OP862_RS12940	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
OP862_RS12950	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
OP862_RS12950	COG1263	PTS System
OP862_RS12955	COG0084	hydrolase, TatD family'
OP862_RS12960	COG0470	DNA polymerase III
OP862_RS12965	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
OP862_RS12970	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
OP862_RS12975	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
OP862_RS12980	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
OP862_RS13005	COG0416	fatty acid biosynthetic process
OP862_RS13010	COG0333	Belongs to the bacterial ribosomal protein bL32 family
OP862_RS13015	COG1399	metal-binding, possibly nucleic acid-binding protein
OP862_RS13025	COG0564	pseudouridine synthase activity
OP862_RS13030	COG1530	ribonuclease E activity
OP862_RS13035	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
OP862_RS13040	COG0418	dihydroorotase activity
OP862_RS13060	COG2197	response regulator
OP862_RS13070	COG0628	permease
OP862_RS13080	COG0697	spore germination
OP862_RS13115	COG1560	Kdo2-lipid A biosynthetic process
OP862_RS13120	COG2259	Doxx family
OP862_RS13125	COG2814	Major facilitator Superfamily
OP862_RS13140	COG5645	(Lipo)protein
OP862_RS13145	COG2943	transferase activity, transferring hexosyl groups
OP862_RS13150	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
OP862_RS13165	COG3263	regulation of cellular component size
OP862_RS13175	COG3916	Acyl-homoserine-lactone synthase
OP862_RS13180	COG2771	luxR family
OP862_RS13185	COG3088	subunit of a heme lyase
OP862_RS13185	COG4235	cytochrome complex assembly
OP862_RS13190	COG3088	subunit of a heme lyase
OP862_RS13195	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
OP862_RS13200	COG1138	Cytochrome C-type biogenesis protein
OP862_RS13205	COG3301	Polysulphide reductase, NrfD
OP862_RS13210	COG0437	4 iron, 4 sulfur cluster binding
OP862_RS13215	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
OP862_RS13245	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
OP862_RS13250	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
OP862_RS13255	COG1263	PTS System
OP862_RS13255	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
OP862_RS13265	COG0698	ribose 5-phosphate isomerase
OP862_RS13270	COG1737	Transcriptional regulator
OP862_RS13275	COG1879	ABC-type sugar transport system periplasmic component
OP862_RS13280	COG1129	ABC transporter
OP862_RS13285	COG1172	Belongs to the binding-protein-dependent transport system permease family
OP862_RS13290	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
OP862_RS13295	COG1940	carbohydrate kinase activity
OP862_RS13300	COG1349	DNA-binding transcription factor activity
OP862_RS13310	COG0738	Major facilitator superfamily
OP862_RS13335	COG2920	part of a sulfur-relay system
OP862_RS13340	COG1254	Belongs to the acylphosphatase family
OP862_RS13350	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
OP862_RS13360	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
OP862_RS13365	COG3785	DNA binding
OP862_RS13370	COG1832	CoA-binding protein
OP862_RS13380	COG1803	Methylglyoxal synthase
OP862_RS13385	COG0210	DNA helicase
OP862_RS13390	COG3304	Inner membrane component domain
OP862_RS13395	COG1289	transmembrane transporter activity
OP862_RS13400	COG3070	regulator of competence-specific genes
OP862_RS13405	COG5404	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
OP862_RS13415	COG3120	sequence-specific DNA binding
OP862_RS13420	COG1067	ATP-dependent peptidase activity
OP862_RS13425	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
OP862_RS13435	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
OP862_RS13440	COG3130	regulation of translation
OP862_RS13445	COG3009	Protein conserved in bacteria
OP862_RS13450	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
OP862_RS13450	COG3008	intermembrane lipid transfer
OP862_RS13455	COG2995	paraquat-inducible protein a
OP862_RS13460	COG0488	(ABC) transporter
OP862_RS13465	COG0116	Belongs to the methyltransferase superfamily
OP862_RS13465	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
OP862_RS13470	COG3217	Mosc domain protein beta barrel domain protein
OP862_RS13470	COG0633	Ferredoxin
OP862_RS13480	COG0167	dihydroorotate dehydrogenase activity
OP862_RS13485	COG0308	aminopeptidase N
OP862_RS13490	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
OP862_RS13495	COG0017	Asparaginyl-tRNA synthetase
OP862_RS13505	COG1448	Aminotransferase
OP862_RS13510	COG2200	EAL domain
OP862_RS13515	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
OP862_RS13520	COG3108	Peptidase M15
OP862_RS13525	COG2989	Protein conserved in bacteria
OP862_RS13540	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
OP862_RS13545	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
OP862_RS13550	COG1434	Gram-negative-bacterium-type cell wall biogenesis
OP862_RS13555	COG3173	Aminoglycoside phosphotransferase
OP862_RS13565	COG2835	tetraacyldisaccharide 4'-kinase activity
OP862_RS13570	COG1278	Cold shock
OP862_RS13575	COG5383	Protein conserved in bacteria
OP862_RS13595	COG0776	regulation of translation
OP862_RS13600	COG0539	negative regulation of cytoplasmic translation
OP862_RS13610	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
OP862_RS13620	COG2323	membrane
OP862_RS13625	COG0252	asparaginase activity
OP862_RS13630	COG1944	ATP diphosphatase activity
OP862_RS13635	COG2116	formate transmembrane transporter activity
OP862_RS13640	COG1882	Formate acetyltransferase
OP862_RS13645	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
OP862_RS13650	COG2814	Major facilitator Superfamily
OP862_RS13655	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
OP862_RS13660	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
OP862_RS13665	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
OP862_RS13670	COG1674	ftsk spoiiie
OP862_RS13670	COG3107	peptidoglycan biosynthetic process
OP862_RS13680	COG0492	ferredoxin-NADP+ reductase activity
OP862_RS13690	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
OP862_RS13695	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
OP862_RS13700	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
OP862_RS13705	COG0542	response to heat
OP862_RS13710	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
OP862_RS13715	COG1278	Cold shock
OP862_RS13725	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
OP862_RS13730	COG2990	Protein conserved in bacteria
OP862_RS13735	COG3593	DNA synthesis involved in DNA repair
OP862_RS13740	COG2431	L-lysine efflux transmembrane transporter activity
OP862_RS13745	COG1151	hydroxylamine reductase activity
OP862_RS13750	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
OP862_RS13755	COG0028	Belongs to the TPP enzyme family
OP862_RS13765	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
OP862_RS13770	COG0702	epimerase
OP862_RS13775	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
OP862_RS13785	COG1605	Chorismate mutase
OP862_RS13790	COG1126	abc transporter atp-binding protein
OP862_RS13795	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
OP862_RS13800	COG4215	(ABC) transporter
OP862_RS13805	COG4160	amino acid transport
OP862_RS13810	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
OP862_RS13825	COG1177	transmembrane transport
OP862_RS13830	COG1176	ABC-type spermidine putrescine transport system, permease component I
OP862_RS13835	COG3842	ATPase activity
OP862_RS13840	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
OP862_RS13860	COG0569	domain protein
OP862_RS13860	COG2985	domain, Protein
OP862_RS13870	COG0671	phosphoesterase, PA-phosphatase related
OP862_RS13875	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
OP862_RS13880	COG1349	DNA-binding transcription factor activity
OP862_RS13885	COG0814	amino acid
OP862_RS13890	COG1760	l-serine dehydratase
OP862_RS13895	COG1686	Belongs to the peptidase S11 family
OP862_RS13905	COG0626	cystathionine gamma-synthase activity
OP862_RS13920	COG2011	ABC-type metal ion transport system permease component
OP862_RS13945	COG0625	glutathione transferase activity
OP862_RS13950	COG4771	TonB-dependent receptor
OP862_RS13955	COG0833	amino acid
OP862_RS13960	COG0583	DNA-binding transcription factor activity
OP862_RS13970	COG2855	membrane
OP862_RS13975	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
OP862_RS13980	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
OP862_RS13980	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
OP862_RS13980	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
OP862_RS13985	COG1105	Belongs to the carbohydrate kinase PfkB family
OP862_RS14010	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
OP862_RS14025	COG0246	Mannitol dehydrogenase
OP862_RS14030	COG2186	Transcriptional regulator
OP862_RS14040	COG0523	cobalamin synthesis protein
OP862_RS14045	COG0671	phosphoesterase, PA-phosphatase related
OP862_RS14050	COG0791	NLP P60 protein
OP862_RS14055	COG2200	EAL domain
OP862_RS14060	COG4166	transmembrane transport
OP862_RS14065	COG4174	ABC transporter (Permease)
OP862_RS14070	COG4239	(ABC) transporter, permease
OP862_RS14075	COG4172	Belongs to the ABC transporter superfamily
OP862_RS14085	COG2814	Major facilitator Superfamily
OP862_RS14090	COG1187	pseudouridine synthase activity
OP862_RS14095	COG1061	Type III restriction enzyme res subunit
OP862_RS14105	COG3081	Nucleoid-associated protein
OP862_RS14110	COG3082	Protein of unknown function (DUF1414)
OP862_RS14135	COG2755	lipolytic protein G-D-S-L family
OP862_RS14135	COG0657	acetylesterase activity
OP862_RS14140	COG3539	Fimbrial protein
OP862_RS14145	COG3539	Fimbrial protein
OP862_RS14150	COG3539	Fimbrial protein
OP862_RS14155	COG3188	usher protein
OP862_RS14160	COG3121	Chaperone
OP862_RS14165	COG3539	Fimbrial protein
OP862_RS14170	COG2723	6-phospho-beta-galactosidase activity
OP862_RS14175	COG1263	PTS System
OP862_RS14175	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
OP862_RS14175	COG2190	(PTS) system
OP862_RS14180	COG1737	Transcriptional regulator
OP862_RS14200	COG3121	Chaperone
OP862_RS14235	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
OP862_RS14260	COG1132	(ABC) transporter
OP862_RS14280	COG2223	nitrite transmembrane transporter activity
OP862_RS14285	COG2198	Histidine kinase
OP862_RS14285	COG0642	Histidine kinase
OP862_RS14295	COG0784	Response regulator, receiver
OP862_RS14295	COG2205	protein histidine kinase activity
OP862_RS14310	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
OP862_RS14325	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
OP862_RS14330	COG4574	serine-type endopeptidase inhibitor activity
OP862_RS14340	COG0814	amino acid
OP862_RS14360	COG1441	menaquinone biosynthetic process
OP862_RS14365	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
OP862_RS14375	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
OP862_RS14380	COG1169	isochorismate synthase
OP862_RS14390	COG4575	ribosome binding
OP862_RS14395	COG0129	dihydroxy-acid dehydratase activity
OP862_RS14400	COG4702	Belongs to the UPF0303 family
OP862_RS14410	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
OP862_RS14415	COG1609	Transcriptional regulator
OP862_RS14420	COG1028	Short-chain dehydrogenase reductase Sdr
OP862_RS14425	COG3265	gluconokinase activity
OP862_RS14430	COG2731	YhcH YjgK YiaL family protein
OP862_RS14450	COG1007	ATP synthesis coupled electron transport
OP862_RS14455	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
OP862_RS14460	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
OP862_RS14465	COG0713	ATP synthesis coupled electron transport
OP862_RS14470	COG0839	Belongs to the complex I subunit 6 family
OP862_RS14475	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
OP862_RS14480	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
OP862_RS14485	COG1034	ATP synthesis coupled electron transport
OP862_RS14500	COG0649	NAD binding
OP862_RS14500	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
OP862_RS14505	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
OP862_RS14510	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
OP862_RS14515	COG0583	DNA-binding transcription factor activity
OP862_RS14525	COG0436	Aminotransferase
OP862_RS14530	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
OP862_RS14535	COG0490	domain, Protein
OP862_RS14535	COG0471	metal ion transport
OP862_RS14545	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
OP862_RS14550	COG3013	Belongs to the UPF0304 family
OP862_RS14555	COG3092	negative regulation of chromosome organization
OP862_RS14565	COG0280	phosphate acetyltransferase
OP862_RS14565	COG0857	belongs to the CobB CobQ family
OP862_RS14570	COG1609	Transcriptional regulator
OP862_RS14575	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
OP862_RS14585	COG3037	sugar-specific permease SgaT UlaA
OP862_RS14595	COG4149	molybdate abc transporter
OP862_RS14605	COG3772	lysozyme
OP862_RS14615	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
OP862_RS14780	COG0582	viral genome integration into host DNA
OP862_RS14785	COG0725	ABC transporter, periplasmic molybdate-binding protein
OP862_RS14795	COG3585	molybdate ion transport
OP862_RS14795	COG2005	Transcriptional regulator
OP862_RS14800	COG1119	ATPase activity
OP862_RS14810	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
OP862_RS14815	COG1085	galactose-1-phosphate uridylyltransferase
OP862_RS14820	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
OP862_RS14825	COG2017	converts alpha-aldose to the beta-anomer
OP862_RS14835	COG0588	phosphoglycerate mutase activity
OP862_RS14840	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
OP862_RS14845	COG1230	cation diffusion facilitator family transporter
OP862_RS14855	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
OP862_RS14885	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
OP862_RS14890	COG2885	chlorophyll binding
OP862_RS14895	COG0823	Involved in the tonB-independent uptake of proteins
OP862_RS14900	COG3064	Membrane
OP862_RS14900	COG3064	Membrane
OP862_RS14905	COG0848	biopolymer transport protein
OP862_RS14910	COG0811	peptide transport
OP862_RS14915	COG0824	Thioesterase
OP862_RS14920	COG3790	cyd operon protein YbgE
OP862_RS14925	COG4890	Cyd operon protein YbgT
OP862_RS14930	COG1294	oxidase, subunit
OP862_RS14935	COG1271	oxidase subunit
OP862_RS14940	COG0737	Belongs to the 5'-nucleotidase family
OP862_RS14945	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
OP862_RS14955	COG0508	dehydrogenase complex catalyzes the overall conversion of
OP862_RS14960	COG0567	Dehydrogenase, E1 component
OP862_RS14965	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
OP862_RS14970	COG1053	succinate dehydrogenase
OP862_RS14975	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
OP862_RS15005	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
OP862_RS15010	COG1984	allophanate hydrolase subunit 2
OP862_RS15015	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
OP862_RS15020	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
OP862_RS15025	COG5212	phosphodiesterase
OP862_RS15035	COG3272	Protein of unknown function (DUF1722)
OP862_RS15050	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
OP862_RS15055	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
OP862_RS15060	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
OP862_RS15065	COG2205	protein histidine kinase activity
OP862_RS15070	COG0745	RESPONSE REGULATOR receiver
OP862_RS15080	COG0033	Phosphoglucomutase
OP862_RS15085	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
OP862_RS15090	COG0596	Alpha beta hydrolase
OP862_RS15100	COG0840	transmembrane signaling receptor activity
OP862_RS15110	COG0735	belongs to the Fur family
OP862_RS15135	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
OP862_RS15140	COG1263	PTS System
OP862_RS15140	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
OP862_RS15140	COG2190	(PTS) system
OP862_RS15150	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
OP862_RS15155	COG1940	carbohydrate kinase activity
OP862_RS15155	COG1846	Transcriptional regulator
OP862_RS15160	COG0647	UMP catabolic process
OP862_RS15165	COG0367	asparagine synthase
OP862_RS15200	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
OP862_RS15205	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
OP862_RS15210	COG1702	phosphate starvation-inducible protein PhoH
OP862_RS15215	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
OP862_RS15220	COG4535	Mg2 and Co2 transporter CorC
OP862_RS15225	COG0815	Transfers the fatty acyl group on membrane lipoproteins
OP862_RS15235	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
OP862_RS15240	COG0765	amino acid transport
OP862_RS15245	COG0765	amino acid transport
OP862_RS15250	COG1126	abc transporter atp-binding protein
OP862_RS15255	COG2888	peptidyl-tyrosine sulfation
OP862_RS15265	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
OP862_RS15270	COG1466	dna polymerase III delta subunit
OP862_RS15275	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
OP862_RS15280	COG0799	negative regulation of ribosome biogenesis
OP862_RS15290	COG0768	penicillin binding
OP862_RS15295	COG0772	Belongs to the SEDS family
OP862_RS15300	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
OP862_RS15305	COG1686	Belongs to the peptidase S11 family
OP862_RS15310	COG2921	Belongs to the UPF0250 family
OP862_RS15315	COG0321	lipoyl(octanoyl) transferase activity
OP862_RS15320	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
OP862_RS15325	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
OP862_RS15330	COG3706	GGDEF domain
OP862_RS15345	COG1278	Cold shock
OP862_RS15350	COG2197	response regulator
OP862_RS15360	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
OP862_RS15375	COG5265	(ABC) transporter
OP862_RS15385	COG2850	peptidyl-arginine hydroxylation
OP862_RS15390	COG2188	Transcriptional regulator
OP862_RS15400	COG0471	metal ion transport
OP862_RS15410	COG2979	Protein of unknown function (DUF533)
OP862_RS15445	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
OP862_RS15450	COG2313	pseudouridylate synthase activity
OP862_RS15455	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
OP862_RS15475	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
OP862_RS15495	COG3064	Membrane
OP862_RS15610	COG0494	nUDIX hydrolase
OP862_RS15645	COG3772	lysozyme
OP862_RS15690	COG0305	Participates in initiation and elongation during chromosome replication
OP862_RS15770	COG3723	Recombinational DNA repair protein, rece pathway
OP862_RS15845	COG0582	viral genome integration into host DNA
OP862_RS15855	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
OP862_RS15860	COG2501	S4 domain
OP862_RS15880	COG3539	Fimbrial protein
OP862_RS15890	COG3121	Chaperone
OP862_RS15895	COG3188	usher protein
OP862_RS15915	COG0215	cysteine-tRNA ligase activity
OP862_RS15920	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
OP862_RS15925	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
OP862_RS15930	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
OP862_RS15935	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
OP862_RS15940	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
OP862_RS15945	COG4181	ATPase activity
OP862_RS15950	COG2755	lipolytic protein G-D-S-L family
OP862_RS15955	COG0300	oxidoreductase activity
OP862_RS15960	COG3118	belongs to the thioredoxin family
OP862_RS15965	COG0330	HflC and HflK could
OP862_RS15970	COG1585	Membrane protein implicated in regulation of membrane protease activity
OP862_RS15975	COG0789	Transcriptional regulator
OP862_RS15980	COG2217	Heavy metal translocating P-type atpase
OP862_RS15985	COG3735	TraB family
OP862_RS15990	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
OP862_RS16125	COG3772	lysozyme
OP862_RS16155	COG1403	HNH endonuclease
OP862_RS16160	COG3645	SOS response
OP862_RS16160	COG3646	Phage regulatory protein
OP862_RS16165	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
OP862_RS16175	COG1846	Transcriptional regulator
OP862_RS16190	COG4197	protein conserved in bacteria, prophage-related
OP862_RS16195	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
OP862_RS16225	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
OP862_RS16260	COG0582	viral genome integration into host DNA
OP862_RS16265	COG0737	Belongs to the 5'-nucleotidase family
OP862_RS16270	COG2223	nitrite transmembrane transporter activity
OP862_RS16275	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
OP862_RS16275	COG4651	solute:proton antiporter activity
OP862_RS16280	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
OP862_RS16285	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
OP862_RS16300	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
OP862_RS16330	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
OP862_RS16335	COG0563	adenylate kinase activity
OP862_RS16340	COG0326	Molecular chaperone. Has ATPase activity
OP862_RS16345	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
OP862_RS16360	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
OP862_RS16365	COG2832	Protein of unknown function (DUF454)
OP862_RS16380	COG1196	nuclear chromosome segregation
OP862_RS16380	COG3264	Mechanosensitive ion channel
OP862_RS16385	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
OP862_RS16390	COG1309	transcriptional regulator
OP862_RS16395	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
OP862_RS16400	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
OP862_RS16410	COG3457	Alanine racemase
OP862_RS16415	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
OP862_RS16420	COG0254	rRNA binding
OP862_RS16425	COG0257	Belongs to the bacterial ribosomal protein bL36 family
OP862_RS16430	COG0803	Belongs to the bacterial solute-binding protein 9 family
OP862_RS16435	COG1108	ABC-type Mn2 Zn2 transport systems permease components
OP862_RS16440	COG1121	(ABC) transporter
OP862_RS16475	COG3695	enzyme binding
OP862_RS16480	COG3126	Type III secretion system lipoprotein chaperone (YscW)
OP862_RS16485	COG1946	Acyl-CoA thioesterase
OP862_RS16490	COG0004	ammonium transporteR
OP862_RS16495	COG0347	Belongs to the P(II) protein family
OP862_RS16500	COG1132	(ABC) transporter
OP862_RS16505	COG1132	(ABC) transporter
OP862_RS16510	COG1522	sequence-specific DNA binding
OP862_RS16520	COG0561	phosphatase activity
OP862_RS16525	COG4533	DNA binding
OP862_RS16530	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
OP862_RS16535	COG0824	Thioesterase
OP862_RS16540	COG1555	photosystem II stabilization
OP862_RS16545	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
OP862_RS16550	COG0776	regulation of translation
OP862_RS16555	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
OP862_RS16560	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
OP862_RS16565	COG0740	serine-type endopeptidase activity
OP862_RS16570	COG0544	peptidyl-prolyl cis-trans isomerase activity
OP862_RS16575	COG0271	Belongs to the BolA IbaG family
OP862_RS16580	COG3056	Lipoprotein
OP862_RS16585	COG2223	nitrite transmembrane transporter activity
OP862_RS16595	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
OP862_RS16600	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
OP862_RS16605	COG1845	cytochrome c oxidase, subunit III
OP862_RS16610	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
OP862_RS16615	COG0109	protoheme IX farnesyltransferase activity
OP862_RS16620	COG2814	Major facilitator Superfamily
OP862_RS16625	COG1666	GTP binding
OP862_RS16630	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
OP862_RS16635	COG0693	protein deglycase activity
OP862_RS16640	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
OP862_RS16640	COG0301	tRNA thio-modification
OP862_RS16650	COG0142	geranyltranstransferase activity
OP862_RS16655	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
OP862_RS16660	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
OP862_RS16665	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
OP862_RS16680	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
OP862_RS16680	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
OP862_RS16685	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
OP862_RS16695	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
OP862_RS16700	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
OP862_RS16705	COG1862	Preprotein translocase
OP862_RS16710	COG0343	queuine tRNA-ribosyltransferase activity
OP862_RS16720	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
OP862_RS16725	COG0450	alkyl hydroperoxide reductase
OP862_RS16740	COG0366	Alpha amylase catalytic
OP862_RS16760	COG5002	protein histidine kinase activity
OP862_RS16765	COG0745	RESPONSE REGULATOR receiver
OP862_RS16770	COG0420	3'-5' exonuclease activity
OP862_RS16775	COG0419	ATPase involved in DNA repair
OP862_RS16780	COG1940	carbohydrate kinase activity
OP862_RS16785	COG2974	May be involved in recombination
OP862_RS16790	COG3123	guanosine phosphorylase activity
OP862_RS16795	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
OP862_RS16810	COG2226	methyltransferase
OP862_RS16825	COG3459	Glycosyltransferase 36 associated
OP862_RS16835	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
OP862_RS16840	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
OP862_RS16850	COG1073	alpha beta
OP862_RS16860	COG2195	Cleaves the N-terminal amino acid of tripeptides
OP862_RS16865	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
OP862_RS16875	COG2991	Protein conserved in bacteria
OP862_RS16880	COG1477	protein flavinylation
OP862_RS16885	COG2871	sodium ion transport
OP862_RS16890	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
OP862_RS16895	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
OP862_RS16900	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
OP862_RS16905	COG1805	sodium ion transport
OP862_RS16910	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
OP862_RS16915	COG3034	peptidoglycan biosynthetic process
OP862_RS16920	COG0121	glutamine amidotransferase
OP862_RS16930	COG1960	acyl-CoA dehydrogenase activity
OP862_RS16935	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
OP862_RS16950	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
OP862_RS16960	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
OP862_RS16970	COG0235	Class ii aldolase
OP862_RS16975	COG0436	Aminotransferase
OP862_RS16985	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
OP862_RS16990	COG2814	Major facilitator Superfamily
OP862_RS16995	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
OP862_RS17005	COG1846	Transcriptional regulator
OP862_RS17010	COG1566	PFAM secretion protein HlyD family protein
OP862_RS17015	COG2814	Major facilitator Superfamily
OP862_RS17020	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
OP862_RS17025	COG3118	belongs to the thioredoxin family
OP862_RS17030	COG3148	PFAM DTW domain containing protein
OP862_RS17035	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
OP862_RS17035	COG0045	succinate-CoA ligase (ADP-forming) activity
OP862_RS17035	COG1042	CoA-binding domain protein
OP862_RS17040	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
OP862_RS17070	COG0542	response to heat
OP862_RS17080	COG0564	pseudouridine synthase activity
OP862_RS17085	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
OP862_RS17090	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
OP862_RS17095	COG1605	Chorismate mutase
OP862_RS17095	COG0077	Prephenate dehydratase
OP862_RS17100	COG0287	Prephenate dehydrogenase
OP862_RS17100	COG1605	Chorismate mutase
OP862_RS17105	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
OP862_RS17110	COG3279	Response regulator of the LytR AlgR family
OP862_RS17115	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
OP862_RS17120	COG3137	Salt-induced outer membrane protein
OP862_RS17125	COG0335	large ribosomal subunit rRNA binding
OP862_RS17135	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
OP862_RS17145	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
OP862_RS17150	COG4137	Cytochrome C assembly protein
OP862_RS17155	COG4536	flavin adenine dinucleotide binding
OP862_RS17160	COG1854	S-ribosylhomocysteine lyase activity
OP862_RS17165	COG2918	glutathione biosynthetic process
OP862_RS17170	COG1238	metal cluster binding
OP862_RS17175	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
OP862_RS17200	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
OP862_RS17205	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
OP862_RS17210	COG2137	regulation of response to DNA damage stimulus
OP862_RS17215	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
OP862_RS17240	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
OP862_RS17245	COG3958	Transketolase
OP862_RS17250	COG3959	Transketolase, thiamine diphosphate binding domain
OP862_RS17255	COG1172	Belongs to the binding-protein-dependent transport system permease family
OP862_RS17260	COG1129	ABC transporter
OP862_RS17270	COG1879	ABC-type sugar transport system periplasmic component
OP862_RS17275	COG3381	protein complex oligomerization
OP862_RS17280	COG3302	dmso reductase anchor subunit
OP862_RS17285	COG0437	4 iron, 4 sulfur cluster binding
OP862_RS17290	COG0243	molybdopterin cofactor binding
OP862_RS17295	COG1454	alcohol dehydrogenase
OP862_RS17300	COG0235	Class ii aldolase
OP862_RS17305	COG0738	Major facilitator superfamily
OP862_RS17315	COG1070	Carbohydrate kinase
OP862_RS17325	COG1349	DNA-binding transcription factor activity
OP862_RS17335	COG1349	DNA-binding transcription factor activity
OP862_RS17345	COG1129	ABC transporter
OP862_RS17350	COG1172	Belongs to the binding-protein-dependent transport system permease family
OP862_RS17360	COG3623	hexulose-6-phosphate isomerase
OP862_RS17365	COG1070	Carbohydrate kinase
OP862_RS17370	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
OP862_RS17370	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
OP862_RS17385	COG4177	L-phenylalanine transmembrane transporter activity
OP862_RS17390	COG1137	ATPase activity
OP862_RS17395	COG0410	ABC transporter
OP862_RS17450	COG0640	Transcriptional regulator
OP862_RS17455	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
OP862_RS17465	COG3077	Addiction module antitoxin, RelB DinJ family
OP862_RS17470	COG3048	D-serine ammonia-lyase activity
OP862_RS17475	COG2610	gluconate transmembrane transporter activity
OP862_RS17480	COG0583	DNA-binding transcription factor activity
OP862_RS17485	COG4608	Belongs to the ABC transporter superfamily
OP862_RS17490	COG0444	Belongs to the ABC transporter superfamily
OP862_RS17495	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
OP862_RS17500	COG0601	transmembrane transport
OP862_RS17505	COG0747	negative chemotaxis
OP862_RS17510	COG4948	Mandelate Racemase Muconate Lactonizing
OP862_RS17515	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
OP862_RS17530	COG1028	Short-chain dehydrogenase reductase Sdr
OP862_RS17550	COG1538	Outer membrane efflux protein
OP862_RS17555	COG0577	efflux transmembrane transporter activity
OP862_RS17555	COG1136	(ABC) transporter
OP862_RS17560	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
OP862_RS17590	COG3539	Fimbrial protein
OP862_RS17595	COG3539	Fimbrial protein
OP862_RS17610	COG3121	Chaperone
OP862_RS17615	COG3188	usher protein
OP862_RS17640	COG3876	Protein conserved in bacteria
OP862_RS17650	COG1472	Belongs to the glycosyl hydrolase 3 family
OP862_RS17660	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
OP862_RS17665	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
OP862_RS17665	COG1263	PTS System
OP862_RS17680	COG3121	Chaperone
OP862_RS17685	COG3121	Chaperone
OP862_RS17695	COG3121	Chaperone
OP862_RS17710	COG0626	cystathionine gamma-synthase activity
OP862_RS17720	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
OP862_RS17725	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
OP862_RS17730	COG1388	LysM domain
OP862_RS17730	COG4942	peptidase
OP862_RS17740	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
OP862_RS17745	COG0585	pseudouridine synthase activity
OP862_RS17750	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
OP862_RS17760	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
OP862_RS17770	COG0765	amino acid transport
OP862_RS17785	COG0529	Catalyzes the synthesis of activated sulfate
OP862_RS17790	COG2895	sulfate adenylyltransferase (ATP) activity
OP862_RS17795	COG0175	sulfate reduction
OP862_RS17800	COG1648	precorrin-2 dehydrogenase activity
OP862_RS17800	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
OP862_RS17805	COG2234	aminopeptidase activity
OP862_RS17815	COG0175	sulfate reduction
OP862_RS17820	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
OP862_RS17825	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
OP862_RS17830	COG0720	synthase
OP862_RS17835	COG0602	queuosine metabolic process
OP862_RS17850	COG0504	CTP synthase activity
OP862_RS17855	COG3956	TIGRFAM MazG family protein
OP862_RS17860	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
OP862_RS17865	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
OP862_RS17875	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
OP862_RS17880	COG0232	Belongs to the dGTPase family. Type 2 subfamily
OP862_RS17885	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
OP862_RS17895	COG2860	membrane
OP862_RS17905	COG0316	Belongs to the HesB IscA family
OP862_RS17915	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
OP862_RS17920	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
OP862_RS17925	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
OP862_RS17930	COG1120	ATPase activity
OP862_RS17935	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
OP862_RS17940	COG1643	Atp-dependent helicase
OP862_RS17945	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
OP862_RS17975	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
OP862_RS17980	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
OP862_RS17985	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
OP862_RS17990	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
OP862_RS17995	COG0726	polysaccharide deacetylase
OP862_RS18000	COG0842	Transport permease protein
OP862_RS18005	COG1131	(ABC) transporter
OP862_RS18010	COG0288	reversible hydration of carbon dioxide
OP862_RS18015	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
OP862_RS18025	COG2132	Multicopper oxidase
OP862_RS18035	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
OP862_RS18050	COG3112	Uncharacterised protein family (UPF0231)
OP862_RS18070	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
OP862_RS18075	COG0508	dehydrogenase complex catalyzes the overall conversion of
OP862_RS18080	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
OP862_RS18085	COG2186	Transcriptional regulator
OP862_RS18090	COG1113	amino acid transport
OP862_RS18100	COG3725	Membrane protein required for beta-lactamase induction
OP862_RS18105	COG3023	N-Acetylmuramoyl-L-alanine amidase
OP862_RS18115	COG4969	Belongs to the N-Me-Phe pilin family
OP862_RS18120	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
OP862_RS18125	COG1459	type II secretion system
OP862_RS18130	COG0516	GMP reductase activity
OP862_RS18145	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
OP862_RS18150	COG0494	nUDIX hydrolase
OP862_RS18155	COG0653	protein targeting
OP862_RS18175	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
OP862_RS18180	COG0849	cell division
OP862_RS18185	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
OP862_RS18195	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
OP862_RS18200	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
OP862_RS18205	COG0772	Belongs to the SEDS family
OP862_RS18215	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
OP862_RS18220	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
OP862_RS18225	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
OP862_RS18230	COG0768	penicillin binding
OP862_RS18235	COG3116	cell division
OP862_RS18240	COG0275	rRNA processing
OP862_RS18265	COG0028	Belongs to the TPP enzyme family
OP862_RS18270	COG1022	Amp-dependent synthetase and ligase
OP862_RS18285	COG0473	3-isopropylmalate dehydrogenase activity
OP862_RS18290	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
OP862_RS18305	COG3033	Beta-eliminating lyase
OP862_RS18310	COG0814	amino acid
OP862_RS18315	COG2814	Major facilitator Superfamily
OP862_RS18320	COG1882	Formate acetyltransferase
OP862_RS18325	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
OP862_RS18330	COG4533	DNA binding
OP862_RS18335	COG4143	(ABC) transporter
OP862_RS18340	COG1178	ABC-type Fe3 transport system permease component
OP862_RS18345	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
OP862_RS18350	COG0586	Pfam SNARE associated Golgi protein
OP862_RS18355	COG0417	DNA replication proofreading
OP862_RS18365	COG2375	cellular response to nickel ion
OP862_RS18400	COG0564	pseudouridine synthase activity
OP862_RS18410	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
OP862_RS18415	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
OP862_RS18430	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
OP862_RS18435	COG2967	ApaG domain
OP862_RS18440	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
OP862_RS18445	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
OP862_RS18455	COG2966	Psort location CytoplasmicMembrane, score
OP862_RS18460	COG1280	lysine exporter protein (LysE YggA)
OP862_RS18465	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
OP862_RS18480	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
OP862_RS18485	COG1047	Peptidyl-prolyl cis-trans
OP862_RS18495	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
OP862_RS18500	COG0196	riboflavin kinase activity
OP862_RS18510	COG0583	DNA-binding transcription factor activity
OP862_RS18515	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
OP862_RS18525	COG0484	heat shock protein binding
OP862_RS18535	COG1584	GPR1 FUN34 yaaH family protein
OP862_RS18550	COG0521	Mo-molybdopterin cofactor biosynthetic process
OP862_RS18555	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
OP862_RS18560	COG3022	response to hydroperoxide
OP862_RS18570	COG0083	homoserine kinase activity
OP862_RS18590	COG0745	RESPONSE REGULATOR receiver
OP862_RS18595	COG3045	CreA protein
OP862_RS18600	COG2207	Transcriptional regulator
OP862_RS18600	COG3708	Transcriptional regulator
OP862_RS18605	COG0406	alpha-ribazole phosphatase activity
OP862_RS18610	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
OP862_RS18615	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
OP862_RS18620	COG0741	lytic transglycosylase activity
OP862_RS18625	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
OP862_RS18635	COG2199	diguanylate cyclase activity
OP862_RS18640	COG2885	chlorophyll binding
OP862_RS18645	COG0488	(ABC) transporter
OP862_RS18680	COG1454	alcohol dehydrogenase
OP862_RS18695	COG0604	alcohol dehydrogenase
OP862_RS18710	COG0560	Phosphoserine phosphatase
OP862_RS18715	COG3726	membrane protein affecting hemolysin expression
OP862_RS18720	COG2026	Addiction module toxin, RelE StbE family
OP862_RS18735	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
OP862_RS18750	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
OP862_RS18755	COG0084	hydrolase, TatD family'
OP862_RS18760	COG4667	esterase of the alpha-beta hydrolase superfamily
OP862_RS18770	COG2823	Periplasmic or secreted lipoprotein
OP862_RS18775	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
OP862_RS18785	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
OP862_RS18790	COG2813	Specifically methylates the guanine in position
OP862_RS18795	COG0667	Aldo Keto reductase
OP862_RS18830	COG3284	Transcriptional regulator
OP862_RS18840	COG0738	Major facilitator superfamily
OP862_RS18855	COG2192	nodulation
OP862_RS18865	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
OP862_RS18865	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
OP862_RS18865	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
OP862_RS18870	COG1461	Dihydroxyacetone kinase
OP862_RS18875	COG2376	Dihydroxyacetone kinase
OP862_RS18885	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
OP862_RS18890	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
OP862_RS18895	COG2235	arginine
OP862_RS18910	COG0859	PFAM glycosyl transferase family 9
OP862_RS18920	COG1070	Carbohydrate kinase
OP862_RS18925	COG2390	Transcriptional regulator
OP862_RS18930	COG1129	ABC transporter
OP862_RS18935	COG1172	Belongs to the binding-protein-dependent transport system permease family
OP862_RS18940	COG1172	Belongs to the binding-protein-dependent transport system permease family
OP862_RS18950	COG1830	Aldolase
OP862_RS18965	COG3550	peptidyl-serine autophosphorylation
OP862_RS18970	COG1396	sequence-specific DNA binding
OP862_RS18985	COG2771	luxR family
OP862_RS19005	COG3409	Peptidoglycan-binding domain 1 protein
OP862_RS19005	COG3429	Glucose-6-phosphate dehydrogenase subunit
OP862_RS19075	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
OP862_RS19105	COG0582	viral genome integration into host DNA
OP862_RS19115	COG0795	lipopolysaccharide-transporting ATPase activity
OP862_RS19120	COG0795	lipopolysaccharide-transporting ATPase activity
OP862_RS19125	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
OP862_RS19130	COG2927	DNA polymerase III (CHI subunit)
OP862_RS19145	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
OP862_RS19155	COG2731	YhcH YjgK YiaL family protein
OP862_RS19165	COG0601	transmembrane transport
OP862_RS19170	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
OP862_RS19175	COG0444	Belongs to the ABC transporter superfamily
OP862_RS19180	COG4608	Belongs to the ABC transporter superfamily
OP862_RS19200	COG0602	queuosine metabolic process
OP862_RS19215	COG2188	Transcriptional regulator
OP862_RS19220	COG3624	Phosphonate C-P lyase system protein PhnG
OP862_RS19225	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
OP862_RS19230	COG3626	phosphonate metabolism
OP862_RS19235	COG3627	carbon phosphorus lyase activity
OP862_RS19240	COG4107	phosphonate C-P lyase system protein PhnK
OP862_RS19245	COG4778	phosphonate C-P lyase system protein PhnL
OP862_RS19250	COG3454	Phosphonate metabolism
OP862_RS19255	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
OP862_RS19260	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
OP862_RS19265	COG0702	epimerase
OP862_RS19280	COG3842	ATPase activity
OP862_RS19285	COG0395	ABC-type sugar transport system, permease component
OP862_RS19290	COG1175	transmembrane transport
OP862_RS19295	COG1653	transport
OP862_RS19315	COG1982	Orn Lys Arg decarboxylase major
OP862_RS19320	COG0531	amino acid
OP862_RS19330	COG3153	acetyltransferase
OP862_RS19335	COG3154	lipid carrier protein
OP862_RS19340	COG0826	peptidase U32
OP862_RS19345	COG0826	peptidase U32
OP862_RS19350	COG3681	Belongs to the UPF0597 family
OP862_RS19355	COG0814	amino acid
OP862_RS19360	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
OP862_RS19365	COG0513	Belongs to the DEAD box helicase family
OP862_RS19375	COG1185	polyribonucleotide nucleotidyltransferase activity
OP862_RS19385	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
OP862_RS19390	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
OP862_RS19400	COG0195	Participates in both transcription termination and antitermination
OP862_RS19420	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
OP862_RS19430	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
OP862_RS19440	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
OP862_RS19445	COG1534	Rna-binding protein
OP862_RS19455	COG2027	D-alanyl-D-alanine carboxypeptidase
OP862_RS19460	COG0745	RESPONSE REGULATOR receiver
OP862_RS19465	COG0642	Histidine kinase
OP862_RS19470	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
OP862_RS19475	COG0697	spore germination
OP862_RS19480	COG0211	Belongs to the bacterial ribosomal protein bL27 family
OP862_RS19490	COG0142	geranyltranstransferase activity
OP862_RS19500	COG3423	Transcriptional regulator
OP862_RS19520	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
OP862_RS19535	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
OP862_RS19540	COG2105	PFAM AIG2 family protein
OP862_RS19545	COG2911	Protein conserved in bacteria
OP862_RS19555	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
OP862_RS19560	COG1253	flavin adenine dinucleotide binding
OP862_RS19570	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
OP862_RS19575	COG1218	3'(2'),5'-bisphosphate nucleotidase
OP862_RS19580	COG0737	Belongs to the 5'-nucleotidase family
OP862_RS19590	COG0545	Peptidyl-prolyl cis-trans isomerase
OP862_RS19595	COG3061	Opacity-associated protein A
OP862_RS19605	COG0359	binds to the 23S rRNA
OP862_RS19610	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
OP862_RS19620	COG0360	Binds together with S18 to 16S ribosomal RNA
OP862_RS19630	COG1073	alpha beta
OP862_RS19635	COG3650	response to hydrogen peroxide
OP862_RS19640	COG1960	acyl-CoA dehydrogenase activity
OP862_RS19645	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
OP862_RS19650	COG0557	exoribonuclease II activity
OP862_RS19655	COG1959	2 iron, 2 sulfur cluster binding
OP862_RS19665	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
OP862_RS19670	COG0330	HflC and HflK could
OP862_RS19675	COG0330	HflC and HflK could
OP862_RS19680	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
OP862_RS19690	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
OP862_RS19695	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
OP862_RS19705	COG0802	atpase or kinase
OP862_RS19710	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
OP862_RS19710	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
OP862_RS19715	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
OP862_RS19735	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
OP862_RS19740	COG1162	GTPase activity
OP862_RS19745	COG0688	phosphatidylethanolamine metabolic process
OP862_RS19750	COG1511	domain protein
OP862_RS19750	COG3264	Mechanosensitive ion channel
OP862_RS19760	COG1053	succinate dehydrogenase
OP862_RS19765	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
OP862_RS19770	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
OP862_RS19775	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
OP862_RS19795	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
OP862_RS19810	COG0459	protein refolding
OP862_RS19815	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
OP862_RS19830	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
OP862_RS19840	COG4232	protein-disulfide reductase activity
OP862_RS19845	COG3383	formate dehydrogenase (NAD+) activity
OP862_RS19850	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
OP862_RS19850	COG0493	'glutamate synthase
OP862_RS19855	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
OP862_RS19855	COG0493	'glutamate synthase
OP862_RS19860	COG2271	Major facilitator Superfamily
OP862_RS19865	COG1929	Belongs to the glycerate kinase type-1 family
OP862_RS19870	COG2721	sulfolactate sulfo-lyase activity
OP862_RS19875	COG3835	regulator
OP862_RS19880	COG1929	Belongs to the glycerate kinase type-1 family
OP862_RS19885	COG2084	Dehydrogenase
OP862_RS19895	COG1309	transcriptional regulator
OP862_RS19905	COG0543	2 iron, 2 sulfur cluster binding
OP862_RS19905	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
OP862_RS19910	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
OP862_RS19940	COG0463	Glycosyl transferase, family 2
OP862_RS19955	COG0489	protein tyrosine kinase activity
OP862_RS19965	COG1215	transferase activity, transferring glycosyl groups
OP862_RS19970	COG0457	Tetratricopeptide repeat
OP862_RS19980	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
OP862_RS19990	COG3721	Heme iron utilization protein
OP862_RS19995	COG0702	epimerase
OP862_RS20010	COG3720	iron ion transport
OP862_RS20015	COG4558	Periplasmic binding protein
OP862_RS20020	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
OP862_RS20025	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
OP862_RS20030	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
OP862_RS20040	COG4774	siderophore transport
OP862_RS20045	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
OP862_RS20045	COG3264	Mechanosensitive ion channel
OP862_RS20055	COG3712	iron ion homeostasis
OP862_RS20060	COG1595	DNA-templated transcription, initiation
OP862_RS20075	COG3093	addiction module antidote protein HigA
OP862_RS20080	COG0425	Belongs to the sulfur carrier protein TusA family
OP862_RS20250	COG1301	dicarboxylic acid transport
OP862_RS20255	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
OP862_RS20260	COG3162	membrane
OP862_RS20265	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
OP862_RS20315	COG0151	Belongs to the GarS family
OP862_RS20335	COG1515	deoxyribonuclease V activity
OP862_RS20345	COG2816	NAD+ diphosphatase activity
OP862_RS20350	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
OP862_RS20365	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
OP862_RS20370	COG2104	thiamine diphosphate biosynthetic process
OP862_RS20385	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
OP862_RS20390	COG0085	RNA polymerase activity
OP862_RS20395	COG0222	ribosome binding
OP862_RS20400	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
OP862_RS20410	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
OP862_RS20415	COG0250	Participates in transcription elongation, termination and antitermination
OP862_RS20455	COG1072	(Pantothenic acid kinase))
OP862_RS20460	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
OP862_RS20460	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
OP862_RS20495	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
OP862_RS20500	COG1739	Uncharacterized protein family UPF0029
OP862_RS20510	COG1024	Enoyl-CoA hydratase
OP862_RS20510	COG1250	3-hydroxyacyl-CoA dehydrogenase
OP862_RS20515	COG0183	Belongs to the thiolase family
OP862_RS20525	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
OP862_RS20545	COG0805	protein transport
OP862_RS20555	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
OP862_RS20560	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
OP862_RS20570	COG2226	methyltransferase
OP862_RS20575	COG1322	Protein conserved in bacteria
OP862_RS20580	COG0586	Pfam SNARE associated Golgi protein
OP862_RS20585	COG1966	Carbon starvation protein
OP862_RS20600	COG0412	Dienelactone hydrolase
OP862_RS20605	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
OP862_RS20610	COG0583	DNA-binding transcription factor activity
OP862_RS20615	COG0697	spore germination
OP862_RS20620	COG0679	Auxin Efflux Carrier
OP862_RS20625	COG0584	glycerophosphoryl diester phosphodiesterase
OP862_RS20630	COG3842	ATPase activity
OP862_RS20635	COG0395	ABC-type sugar transport system, permease component
OP862_RS20640	COG1175	transmembrane transport
OP862_RS20645	COG1653	transport
OP862_RS20680	COG0410	ABC transporter
OP862_RS20690	COG4177	L-phenylalanine transmembrane transporter activity
OP862_RS20700	COG0683	leucine binding
OP862_RS20705	COG0456	acetyltransferase
OP862_RS20715	COG2177	Part of the ABC transporter FtsEX involved in
OP862_RS20720	COG2884	Cell division ATP-binding protein ftsE
OP862_RS20725	COG0552	protein localization to endoplasmic reticulum
OP862_RS20725	COG0552	protein localization to endoplasmic reticulum
OP862_RS20730	COG0742	ribosomal rna small subunit methyltransferase
OP862_RS20735	COG3776	membrane
OP862_RS20750	COG3714	YhhN family
OP862_RS20760	COG0425	Belongs to the sulfur carrier protein TusA family
OP862_RS20765	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
OP862_RS20775	COG0247	lactate metabolic process
OP862_RS20785	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
OP862_RS20795	COG2271	Major facilitator Superfamily
OP862_RS20800	COG0584	glycerophosphoryl diester phosphodiesterase
OP862_RS20805	COG0561	phosphatase activity
OP862_RS20810	COG2267	carboxylic ester hydrolase activity
OP862_RS20815	COG1280	lysine exporter protein (LysE YggA)
OP862_RS20820	COG1280	lysine exporter protein (LysE YggA)
OP862_RS20825	COG0514	ATP-dependent DNA helicase (RecQ)
OP862_RS20830	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
OP862_RS20835	COG2050	protein possibly involved in aromatic compounds catabolism
OP862_RS20850	COG5564	TIM-barrel signal transduction protein
OP862_RS20855	COG5441	Belongs to the UPF0261 family
OP862_RS20865	COG0210	DNA helicase
OP862_RS20870	COG1011	Hydrolase
OP862_RS20875	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
OP862_RS20880	COG3159	Protein conserved in bacteria
OP862_RS20885	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
OP862_RS20890	COG5567	small periplasmic lipoprotein
OP862_RS20900	COG3072	Adenylate cyclase
OP862_RS20905	COG0181	hydroxymethylbilane synthase activity
OP862_RS20910	COG1587	Uroporphyrinogen-III synthase
OP862_RS20915	COG2959	enzyme of heme biosynthesis
OP862_RS20920	COG3071	HemY protein
OP862_RS20945	COG1113	amino acid transport
OP862_RS20960	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
OP862_RS20965	COG2244	polysaccharide biosynthetic process
OP862_RS20970	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
OP862_RS20975	COG0456	acetyltransferase
OP862_RS20980	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
OP862_RS20985	COG1088	dTDP-glucose 4,6-dehydratase activity
OP862_RS20990	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
OP862_RS20995	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
OP862_RS21000	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
OP862_RS21005	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
OP862_RS21010	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
OP862_RS21015	COG3118	belongs to the thioredoxin family
OP862_RS21025	COG0248	Ppx GppA phosphatase
OP862_RS21040	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
OP862_RS21050	COG3121	Chaperone
OP862_RS21065	COG3121	Chaperone
OP862_RS21070	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
OP862_RS21075	COG0583	DNA-binding transcription factor activity
OP862_RS21085	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
OP862_RS21090	COG0129	dihydroxy-acid dehydratase activity
OP862_RS21095	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
OP862_RS21100	COG3978	acetolactate synthase activity
OP862_RS21120	COG3085	chromosome segregation
OP862_RS21125	COG0583	DNA-binding transcription factor activity
OP862_RS21130	COG1172	Belongs to the binding-protein-dependent transport system permease family
OP862_RS21135	COG1172	Belongs to the binding-protein-dependent transport system permease family
OP862_RS21140	COG1129	ABC transporter
OP862_RS21145	COG1879	ABC-type sugar transport system periplasmic component
OP862_RS21185	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
OP862_RS21195	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
OP862_RS21210	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
OP862_RS21220	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
OP862_RS21220	COG0678	peroxiredoxin activity
OP862_RS21225	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
OP862_RS21250	COG1629	transport
OP862_RS21255	COG0165	Argininosuccinate lyase
OP862_RS21275	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
OP862_RS21285	COG2814	Major facilitator Superfamily
OP862_RS21290	COG1494	fructose-1,6-bisphosphatase
OP862_RS21295	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
OP862_RS21300	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
OP862_RS21305	COG3074	FtsZ-dependent cytokinesis
OP862_RS21310	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
OP862_RS21315	COG1575	Belongs to the MenA family. Type 1 subfamily
OP862_RS21320	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
OP862_RS21325	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
OP862_RS21330	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
OP862_RS21335	COG1609	Transcriptional regulator
OP862_RS21340	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
OP862_RS21345	COG0254	rRNA binding
OP862_RS21350	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
OP862_RS21355	COG0626	cystathionine gamma-synthase activity
OP862_RS21360	COG0527	aspartate kinase activity
OP862_RS21360	COG0460	homoserine dehydrogenase
OP862_RS21370	COG3152	Membrane
OP862_RS21390	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
OP862_RS21400	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
OP862_RS21405	COG3678	ATP-independent chaperone mediated protein folding
OP862_RS21410	COG0745	RESPONSE REGULATOR receiver
OP862_RS21415	COG2205	protein histidine kinase activity
OP862_RS21420	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
OP862_RS21420	COG2169	Transcriptional regulator
OP862_RS21425	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
OP862_RS21430	COG1045	serine acetyltransferase
OP862_RS21435	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
OP862_RS21440	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
OP862_RS21445	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
OP862_RS21450	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
OP862_RS21455	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
OP862_RS21460	COG4942	peptidase
OP862_RS21465	COG2861	carbohydrate metabolic process
OP862_RS21475	COG0156	8-amino-7-oxononanoate synthase activity
OP862_RS21480	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
OP862_RS21485	COG0859	PFAM glycosyl transferase family 9
OP862_RS21490	COG0859	PFAM glycosyl transferase family 9
OP862_RS21495	COG1519	Transferase
OP862_RS21510	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
OP862_RS21515	COG0267	Belongs to the bacterial ribosomal protein bL33 family
OP862_RS21520	COG0227	Belongs to the bacterial ribosomal protein bL28 family
OP862_RS21530	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
OP862_RS21535	COG0756	dUTP diphosphatase activity
OP862_RS21540	COG1309	transcriptional regulator
OP862_RS21550	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
OP862_RS21555	COG2200	EAL domain
OP862_RS21555	COG2199	diguanylate cyclase activity
OP862_RS21560	COG4608	Belongs to the ABC transporter superfamily
OP862_RS21565	COG0444	Belongs to the ABC transporter superfamily
OP862_RS21570	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
OP862_RS21575	COG0601	transmembrane transport
OP862_RS21580	COG0747	negative chemotaxis
OP862_RS21590	COG2831	hemolysin activation secretion protein
OP862_RS21600	COG2271	Major facilitator Superfamily
OP862_RS21605	COG3851	Histidine kinase
OP862_RS21610	COG2197	response regulator
OP862_RS21615	COG2194	sulfuric ester hydrolase activity
OP862_RS21620	COG1764	response to oxidative stress
OP862_RS21635	COG2986	histidine ammonia-lyase
OP862_RS21640	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
OP862_RS21645	COG5001	Diguanylate cyclase
OP862_RS21650	COG1024	Enoyl-CoA hydratase
OP862_RS21655	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
OP862_RS21665	COG2860	membrane
OP862_RS21670	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
OP862_RS21680	COG1758	RNA polymerase activity
OP862_RS21685	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
OP862_RS21690	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
OP862_RS21695	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
OP862_RS21700	COG0786	glutamate:sodium symporter activity
OP862_RS21705	COG2233	PERMEase
OP862_RS21710	COG2982	Protein involved in outer membrane biogenesis
OP862_RS21730	COG0456	acetyltransferase
OP862_RS21740	COG1295	ribonuclease BN
OP862_RS21745	COG1011	Hydrolase
OP862_RS21760	COG3852	Histidine kinase
OP862_RS21770	COG0635	Involved in the biosynthesis of porphyrin-containing compound
OP862_RS21775	COG3078	GTPase activator activity
OP862_RS21780	COG0218	Necessary for normal cell division and for the maintenance of normal septation
OP862_RS21785	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
OP862_RS21785	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
OP862_RS21790	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
OP862_RS21795	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
OP862_RS21800	COG3084	Protein conserved in bacteria
OP862_RS21810	COG1763	Mo-molybdopterin cofactor biosynthetic process
OP862_RS21835	COG2186	Transcriptional regulator
OP862_RS21840	COG0477	Major facilitator Superfamily
OP862_RS21845	COG1609	Transcriptional regulator
OP862_RS21850	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
OP862_RS21855	COG1879	ABC-type sugar transport system periplasmic component
OP862_RS21860	COG1172	Belongs to the binding-protein-dependent transport system permease family
OP862_RS21870	COG1869	D-ribose catabolic process
OP862_RS21875	COG3158	transport of potassium into the cell
OP862_RS21880	COG0714	Associated with various cellular activities
OP862_RS21885	COG2425	protein containing a von Willebrand factor type A (vWA) domain
OP862_RS21895	COG2502	aspartate--ammonia ligase
OP862_RS21900	COG1522	sequence-specific DNA binding
OP862_RS21905	COG0716	FMN binding
OP862_RS21910	COG0445	tRNA wobble uridine modification
OP862_RS21915	COG0357	Ribosomal RNA small subunit methyltransferase G
OP862_RS21920	COG3312	ion transport
OP862_RS21925	COG0356	it plays a direct role in the translocation of protons across the membrane
OP862_RS21935	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
OP862_RS21940	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
OP862_RS21945	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
OP862_RS21950	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
OP862_RS21955	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
OP862_RS21960	COG0355	proton-transporting ATP synthase activity, rotational mechanism
OP862_RS21965	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
OP862_RS21975	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
OP862_RS21980	COG0573	inorganic phosphate transmembrane transporter activity
OP862_RS21985	COG0581	inorganic phosphate transmembrane transporter activity
OP862_RS21995	COG0704	Plays a role in the regulation of phosphate uptake
OP862_RS22000	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
OP862_RS22005	COG0765	amino acid transport
OP862_RS22010	COG0765	amino acid transport
OP862_RS22015	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
OP862_RS22020	COG2252	PERMEase
OP862_RS22035	COG4191	Histidine kinase
OP862_RS22040	COG0431	NADPH-dependent FMN reductase
OP862_RS22045	COG0840	transmembrane signaling receptor activity
OP862_RS22050	COG2011	ABC-type metal ion transport system permease component
OP862_RS22055	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
OP862_RS22085	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
OP862_RS22090	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
OP862_RS22095	COG0706	membrane insertase activity
OP862_RS22105	COG0594	ribonuclease P activity
OP862_RS22110	COG0230	Belongs to the bacterial ribosomal protein bL34 family